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Isabella Fiorini

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Sandra Gemma; Roberta Gualdani; Annette Habluetzel; Gagan Kukreja; Sanil Kunjir; Stefania Lamponi; Leonardo Lucantoni; Rowena E Martin; Maria Rosa Moncelli; Ettore Novellino; Luisa Savini; Robert L Summers; Francesco Tadini Buoninsegni; Donatella Taramelli; massimo valoti; Gianluca Bartolommei; Nicoletta Basilico; Margherita Brindisi; Simone Brogi; Caterina Camodeca; Giuseppe Campiani; Isabella Fiorini; Emanuele Gabellieri; Stefania Butini
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
Sandra Gemma; Simone Giovani; Ettore Novellino; Maria Penzo; Luisa Savini; Pierangela Tripaldi; Margherita Brindisi; Simone Brogi; Stefania Butini; Giuseppe Campiani; Isabella Fiorini; Michael J Blackman
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Sandra Gemma; Gianluca Giorgi; Bhupendra P Joshi; Ettore Novellino; Mario Salmona; Luisa Savini; Orazio Taglialatela-Scafati; Pierangela Tripaldi; Silvio Caccia; Giuseppe Campiani; Laura Colombo; Isabella Fiorini; Gianluigi Forloni; Claudia Fracasso; Margherita Brindisi; Stefania Butini
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.

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All Publications

2012: Sandra Gemma; Roberta Gualdani; Annette Habluetzel; Gagan Kukreja; Sanil Kunjir; Stefania Lamponi; Leonardo Lucantoni; Rowena E Martin; Maria Rosa Moncelli; Ettore Novellino; Luisa Savini; Robert L Summers; Francesco Tadini Buoninsegni; Donatella Taramelli; massimo valoti; Gianluca Bartolommei; Nicoletta Basilico; Margherita Brindisi; Simone Brogi; Caterina Camodeca; Giuseppe Campiani; Isabella Fiorini; Emanuele Gabellieri; Stefania Butini
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
Journal of medicinal chemistry 2012;55(23):10387-404.
2012: Sandra Gemma; Simone Giovani; Ettore Novellino; Maria Penzo; Luisa Savini; Pierangela Tripaldi; Margherita Brindisi; Simone Brogi; Stefania Butini; Giuseppe Campiani; Isabella Fiorini; Michael J Blackman
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Bioorganic & medicinal chemistry letters 2012;22(16):5317-21.
2011: Sandra Gemma; Gianluca Giorgi; Bhupendra P Joshi; Ettore Novellino; Mario Salmona; Luisa Savini; Orazio Taglialatela-Scafati; Pierangela Tripaldi; Silvio Caccia; Giuseppe Campiani; Laura Colombo; Isabella Fiorini; Gianluigi Forloni; Claudia Fracasso; Margherita Brindisi; Stefania Butini
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.
Organic & biomolecular chemistry 2011;9(14):5137-48.
2011: Stefania Butini; Giuseppe Campiani; Marcella Facchini; Isabella Fiorini; Federico Focher; Sandra Gemma; Aristotele Karytinos; Andrea Lossani; Giuseppe Borrelli; Margherita Brindisi; Ettore Novellino; Alberta Samuele; Samantha Zanoli; giovanni maga
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
Bioorganic & medicinal chemistry letters 2011;21(13):3935-8.
2011: Sandra Gemma; Stefania Butini; Giuseppe Campiani; Margherita Brindisi; Samantha Zanoli; Maria Pia Romano; Pierangela Tripaldi; Luisa Savini; Isabella Fiorini; Giuseppe Borrelli; Ettore Novellino; giovanni maga
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.
Bioorganic & medicinal chemistry letters 2011;21(9):2776-9.
2011: Stefania Butini; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Andrea Lossani; Anna Maria Ponte; Andrea Torti; giovanni maga; Luciana Marinelli; Valeria La Pietra; Isabella Fiorini; Stefania Lamponi; Giuseppe Campiani; Daniela M Zisterer; Seema-Maria Nathwani; Stefania Sartini; Concettina La Motta; Federico Da Settimo; Ettore Novellino; Federico Focher
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.
Journal of medicinal chemistry 2011;54(5):1401-20.
2010: Stefania Butini; Giuseppe Campiani; Silvia Franceschini; Francesco Trotta; Vinod Kumar; Egeria Guarino; Giuseppe Borrelli; Isabella Fiorini; Ettore Novellino; Caterina Fattorusso; Marco Persico; Nausicaa Orteca; Karin Sandager-Nielsen; Thomas Amos Jacobsen; Kim Madsen; Jorgen Scheel-Kruger; Sandra Gemma
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.
Journal of medicinal chemistry 2010;53(12):4803-7.
2005: Caterina Fattorusso; Sandra Gemma; Stefania Butini; Paul Huleatt; Bruno Catalanotti; Marco Persico; Meri De Angelis; Isabella Fiorini; Vito Nacci; Anna Ramunno; Manuela Rodriquez; Giovanni Greco; Ettore Novellino; Alberto Bergamini; Stefano Marini; Massimo Coletta; giovanni maga; Silvio Spadari; Giuseppe Campiani
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
Journal of medicinal chemistry 2005;48(23):7153-65.
2005: Margaret M Mc Gee; Sandra Gemma; Stefania Butini; Anna Ramunno; Daniela M Zisterer; Caterina Fattorusso; Bruno Catalanotti; Gagan Kukreja; Isabella Fiorini; Claudio Pisano; Carla Cucco; Ettore Novellino; Vito Nacci; D Clive Williams; Giuseppe Campiani
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target.
Journal of medicinal chemistry 2005;48(13):4367-77.
2005: Giuseppe Campiani; Stefania Butini; Caterina Fattorusso; Francesco Trotta; Sandra Gemma; Bruno Catalanotti; Vito Nacci; Isabella Fiorini; Alfredo Cagnotto; Ilario Mereghetti; Tiziana Mennini; Patrizia Minetti; M Assunta Di Cesare; M Antonietta Stasi; Stefano Di Serio; Orlando Ghirardi; Ornella Tinti; Paolo Carminati
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.
Journal of medicinal chemistry 2005;48(6):1705-8.
2003: Giuseppe Campiani; Caterina Fattorusso; Meri De Angelis; Bruno Catalanotti; Stefania Butini; Roberto Fattorusso; Isabella Fiorini; Vito Nacci; Ettore Novellino
Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases.
Current pharmaceutical design 2003;9(8):599-625.
2002: Giuseppe Campiani; Anna Ramunno; Isabella Fiorini; Vito Nacci; Elena Morelli; Ettore Novellino; Mara Goegan; Tiziana Mennini; Stephen Sullivan; Daniela M Zisterer; Clive D Williams
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).
Journal of medicinal chemistry 2002;45(19):4276-81.
2001: giovanni maga; Anna Ramunno; Vito Nacci; Giada A Locatelli; Silvio Spadari; Isabella Fiorini; Fausto Baldanti; Stefania Paolucci; Maurizio Zavattoni; Alberto Bergamini; Bruno Galletti; S Muck; Ulrich Hubscher; G Giorgi; Giovanna Guiso; S Caccia; Giuseppe Campiani
The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors.
The Journal of biological chemistry 2001;276(48):44653-62.
1999: Nouri Neamati; Jim A Turpin; Heather E Winslow; JL Christensen; K Williamson; Ann H Orr; William G Rice; Yves Pommier; Antonio Garofalo; Antonella Brizzi; Giuseppe Campiani; Isabella Fiorini; Vito Nacci
Thiazolothiazepine inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1999;42(17):3334-41.
1998: Giuseppe Campiani; Vito Nacci; S Bechelli; S M Ciani; Antonio Garofalo; Isabella Fiorini; H Wikström; P de Boer; Y Liao; P G Tepper; Alfredo Cagnotto; Tiziana Mennini
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.
Journal of medicinal chemistry 1998;41(20):3763-72.
1996: Giuseppe Campiani; Vito Nacci; Isabella Fiorini; M P De Filippis; Antonio Garofalo; S M Ciani; Giovanni Greco; Ettore Novellino; D C Williams; Daniela M Zisterer; M J Woods; C Mihai; C Manzoni; Tiziana Mennini
Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.
Journal of medicinal chemistry 1996;39(18):3435-50.
1996: Giuseppe Campiani; Isabella Fiorini; M P De Filippis; S M Ciani; Antonio Garofalo; Vito Nacci; Gianluca Giorgi; A Sega; Maurizio Botta; Alberto Chiarini; Roberta Budriesi; Giancarlo Bruni; M R Romeo; C Manzoni; Tiziana Mennini
Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers.
Journal of medicinal chemistry 1996;39(15):2922-38.
1996: Giuseppe Campiani; Vito Nacci; Isabella Fiorini; M P De Filippis; Antonio Garofalo; Giovanni Greco; Ettore Novellino; Sergio Altamura; L Di Renzo
Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.
Journal of medicinal chemistry 1996;39(14):2672-80.
1995: Alessandro Dalpiaz; V Bertolasi; Pier Andrea Borea; Vito Nacci; Isabella Fiorini; Giuseppe Campiani; Tiziana Mennini; C Manzoni; Ettore Novellino; Giovanni Greco
A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.
Journal of medicinal chemistry 1995;38(23):4730-8.
1995: Giuseppe Campiani; Antonio Garofalo; Isabella Fiorini; Maurizio Botta; Vito Nacci; Andrea Tafi; Alberto Chiarini; Roberta Budriesi; Giancarlo Bruni; M R Romeo
Pyrrolo[2,1-c][1,4]benzothiazines: synthesis, structure-activity relationships, molecular modeling studies, and cardiovascular activity.
Journal of medicinal chemistry 1995;38(22):4393-410.
1994: Giovanni Greco; Ettore Novellino; Isabella Fiorini; Vito Nacci; Giuseppe Campiani; S M Ciani; Antonio Garofalo; P Bernasconi; Tiziana Mennini
A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor.
Journal of medicinal chemistry 1994;37(24):4100-8.
1994: Isabella Fiorini; Vito Nacci; S M Ciani; Antonio Garofalo; Giuseppe Campiani; Luisa Savini; Ettore Novellino; Giovanni Greco; P Bernasconi; Tiziana Mennini
Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 1994;37(10):1427-38.
1993: Antonio Garofalo; Giuseppe Campiani; Isabella Fiorini; Vito Nacci
Benzothiazine and benzothiazepine derivatives: synthesis and preliminary biological evaluation.
Farmaco (Società chimica italiana : 1989) 1993;48(2):275-83.
1993: Luisa Savini; Paola Massarelli; Cesare Pellerano; Isabella Fiorini; Giancarlo Bruni; M R Romeo
Pyrazolo [4,3-c] quinolines synthesis and specific inhibition of benzodiazepine receptor binding (Note I).
Farmaco (Società chimica italiana : 1989) 1993;48(1):65-76.
1990: Vito Nacci; Isabella Fiorini; Antonio Garofalo; Alfredo Cagnotto
Research on compounds with psychotropic activity. IX--Synthesis of 6-p-methoxyphenylpyrrolo[2,1-d][1,5]benzothiazepines and evaluation of their affinities for BDZ and GABA receptor subtypes.
Farmaco (Società chimica italiana : 1989) 1990;45(5):545-58.
1984: Vito Nacci; Isabella Fiorini; Salvatore Vomero; I Taddei; E Taddei
[Compounds with psychotropic activity. VIII. Synthesis and sedative activity of various 9-substituted derivatives of 5-phenylpyrrolo[2,1-d][1,5] benzothiazepine and cis-4,5-dihydro-4-hydroxy-5-phenylpyrrolo[2,1-d][1,5]benzothiazepine].
Il Farmaco; edizione scientifica 1984;39(4):289-304.
1980: Vito Nacci; Isabella Fiorini; P Corti; I Taddei; F Bernabei; P Fratiglioni
[Research on a compound with psychotropic activity. V - a new derivative of pyrrolo[2,1-d][1,5]benzothiazepin-6,6-dioxide: synthesis and sedative activity].
Il Farmaco; edizione scientifica 1980;35(4):279-97.