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Andrew Fire
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Research Profile (preview)
Living Beings
Chemicals & Drugs
Concepts & Ideas
Anatomy
Genes & Molecular Sequences
Physiology
Procedures
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Network (preview)
10
Sharp, Phillip
9
Krause, Michael
8
Mello, Craig
6
Parrish, Susan
6
Fleenor, Jamie
5
Kostas, Stephen
5
Montgomery, MK
5
Timmons, Lisa D.
4
Liu, Jun
4
Tan, Frederick
4
Harfe, BD
3
Kelly, WG
3
Lui, Weng-Onn
3
Caplen, Natasha
3
Okkema, Peter
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Publications
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All Publications
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2009: Ma Zhihai; Lui Weng-Onn; Fire Andrew; Dadras Soheil S
Profiling and discovery of novel miRNAs from formalin-fixed, paraffin-embedded melanoma and nodal specimens.
The Journal of molecular diagnostics : JMD 2009;11(5):420-9.
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2009: Lei Haiyan; Liu Jun; Fukushige Tetsunari; Fire Andrew; Krause Michael
Caudal-like PAL-1 directly activates the bodywall muscle module regulator hlh-1 in C. elegans to initiate the embryonic muscle gene regulatory network.
Development (Cambridge, England) 2009;136(8):1241-9.
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2009: Sasaki Shin; Mello Cecilia C; Shimada Atsuko; Nakatani Yoichiro; Hashimoto Shin-Ichi; Ogawa Masako; Matsushima Kouji; Gu Sam Guoping; Kasahara Masahiro; Ahsan Budrul; Sasaki Atsushi; Saito Taro; Suzuki Yutaka; Sugano Sumio; Kohara Yuji; Takeda Hiroyuki; Fire Andrew; Morishita Shinichi
Chromatin-associated periodicity in genetic variation downstream of transcriptional start sites.
Science (New York, N.Y.) 2009;323(5912):401-4.
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2008: Tan Frederick J; Husain Michelle; Manlandro Cara Marie; Koppenol Marijke; Fire Andrew Z; Hill R Blake
CED-9 and mitochondrial homeostasis in C. elegans muscle.
Journal of cell science 2008;121(Pt 20):3373-82.
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2008: Haussecker Dirk; Cao Dan; Huang Yong; Parameswaran Poornima; Fire Andrew Z; Kay Mark A
Capped small RNAs and MOV10 in human hepatitis delta virus replication.
Nature structural & molecular biology 2008;15(7):714-21.
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2008: Valouev Anton; Ichikawa Jeffrey; Tonthat Thaisan; Stuart Jeremy; Ranade Swati; Peckham Heather; Zeng Kathy; Malek Joel A; Costa Gina; McKernan Kevin; Sidow Arend; Fire Andrew; Johnson Steven M
A high-resolution, nucleosome position map of C. elegans reveals a lack of universal sequence-dictated positioning.
Genome research 2008;18(7):1051-63.
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2008: Subramanian S; Lui W O; Lee C H; Espinosa I; Nielsen T O; Heinrich M C; Corless C L; Fire A Z; van de Rijn M
MicroRNA expression signature of human sarcomas.
Oncogene 2008;27(14):2015-26.
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2007: Fire Andrew Z
Gene silencing by double-stranded RNA.
Cell death and differentiation 2007;14(12):1998-2012.
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2007: Tan F J; Fire A Z; Hill R B
Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain.
Cell death and differentiation 2007;14(11):1925-35.
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2007: Gu Sam G; Pak Julia; Barberan-Soler Sergio; Ali Mustapha; Fire Andrew; Zahler Alan M
Distinct ribonucleoprotein reservoirs for microRNA and siRNA populations in C. elegans.
RNA (New York, N.Y.) 2007;13(9):1492-504.
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2007: Lui Weng-Onn; Pourmand Nader; Patterson Bruce K; Fire Andrew
Patterns of known and novel small RNAs in human cervical cancer.
Cancer research 2007;67(13):6031-43.
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2007: Pak Julia; Fire Andrew
Distinct populations of primary and secondary effectors during RNAi in C. elegans.
Science (New York, N.Y.) 2007;315(5809):241-4.
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2007: Parameswaran Poornima; Jalili Roxana; Tao Li; Shokralla Shadi; Gharizadeh Baback; Ronaghi Mostafa; Fire Andrew Z
A pyrosequencing-tailored nucleotide barcode design unveils opportunities for large-scale sample multiplexing.
Nucleic acids research 2007;35(19):e130.
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2007: Akhras Michael S; Unemo Magnus; Thiyagarajan Sreedevi; Nyrén Pål; Davis Ronald W; Fire Andrew Z; Pourmand Nader
Connector inversion probe technology: a powerful one-primer multiplex DNA amplification system for numerous scientific applications.
PloS one 2007;2(9):e915.
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2007: Fire Andrew Z
Gene silencing by double-stranded RNA (Nobel Lecture).
Angewandte Chemie (International ed. in English) 2007;46(37):6966-84.
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2006: Johnson Steven M; Tan Frederick J; McCullough Heather L; Riordan Daniel P; Fire Andrew Z
Flexibility and constraint in the nucleosome core landscape of Caenorhabditis elegans chromatin.
Genome research 2006;16(12):1505-16.
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2006: Blanchard Daniel; Hutter Harald; Fleenor Jamie; Fire Andrew
A differential cytolocalization assay for analysis of macromolecular assemblies in the eukaryotic cytoplasm.
Molecular & cellular proteomics : MCP 2006;5(11):2175-84.
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2006: Foehr Marisa L; Lindy Amanda S; Fairbank Rachel C; Amin Nirav M; Xu Ming; Yanowitz Judith; Fire Andrew Z; Liu Jun
An antagonistic role for the C. elegans Schnurri homolog SMA-9 in modulating TGFbeta signaling during mesodermal patterning.
Development (Cambridge, England) 2006;133(15):2887-96.
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2006: Fire Andrew; Alcazar Rosa; Tan Frederick
Unusual DNA structures associated with germline genetic activity in Caenorhabditis elegans.
Genetics 2006;173(3):1259-73.
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2006: Moreno-Herrero Fernando; Seidel Ralf; Johnson Steven M; Fire Andrew; Dekker Nynke H
Structural analysis of hyperperiodic DNA from Caenorhabditis elegans.
Nucleic acids research 2006;34(10):3057-66.
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2005: Fire Andrew
Nucleic acid structure and intracellular immunity: some recent ideas from the world of RNAi.
Quarterly reviews of biophysics 2005;38(4):303-9.
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2005: Sha Ky; Fire Andrew
Imprinting capacity of gamete lineages in Caenorhabditis elegans.
Genetics 2005;170(4):1633-52.
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2005: Yanowitz Judith; Fire Andrew
Cyclin D involvement demarcates a late transition in C. elegans embryogenesis.
Developmental biology 2005;279(1):244-51.
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2004: Yanowitz Judith L; Shakir M Afaq; Hedgecock Edward; Hutter Harald; Fire Andrew Z; Lundquist Erik A
UNC-39, the C. elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation.
Developmental biology 2004;272(2):389-402.
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2003: Timmons Lisa; Tabara Hiroaki; Mello Craig C; Fire Andrew Z
Inducible systemic RNA silencing in Caenorhabditis elegans.
Molecular biology of the cell 2003;14(7):2972-83.
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2002: Simmer Femke; Tijsterman Marcel; Parrish Susan; Koushika Sandhya P; Nonet Michael L; Fire Andrew; Ahringer Julie; Plasterk Ronald H A
Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.
Current biology : CB 2002;12(15):1317-9.
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2002: Caplen Natasha J; Taylor J Paul; Statham Victoria S; Tanaka Fumiaki; Fire Andrew; Morgan Richard A
Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference.
Human molecular genetics 2002;11(2):175-84.
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2002: Kostas Stephen A; Fire Andrew
The T-box factor MLS-1 acts as a molecular switch during specification of nonstriated muscle in C. elegans.
Genes & development 2002;16(2):257-69.
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2001: Sijen T; Fleenor J; Simmer F; Thijssen K L; Parrish S; Timmons L; Plasterk R H; Fire A
On the role of RNA amplification in dsRNA-triggered gene silencing.
Cell 2001;107(4):465-76.
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2001: Parrish S; Fire A
Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans.
RNA (New York, N.Y.) 2001;7(10):1397-402.
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2001: Caplen N J; Parrish S; Imani F; Fire A; Morgan R A
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9742-7.
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2001: Grishok A; Pasquinelli A E; Conte D; Li N; Parrish S; Ha I; Baillie D L; Fire A; Ruvkun G; Mello C C
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.
Cell 2001;106(1):23-34.
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2001: Timmons L; Court D L; Fire A
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans.
Gene 2001;263(1-2):103-12.
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2000: Liu J; Fire A
Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm.
Development (Cambridge, England) 2000;127(23):5179-90.
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2000: Parrish S; Fleenor J; Xu S; Mello C; Fire A
Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference.
Molecular cell 2000;6(5):1077-87.
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2000: Liu J; Rolef Ben-Shahar T; Riemer D; Treinin M; Spann P; Weber K; Fire A; Gruenbaum Y
Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes.
Molecular biology of the cell 2000;11(11):3937-47.
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2000: Caplen N J; Fleenor J; Fire A; Morgan R A
dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference.
Gene 2000;252(1-2):95-105.
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2000: Dichoso D; Brodigan T; Chwoe K Y; Lee J S; Llacer R; Park M; Corsi A K; Kostas S A; Fire A; Ahnn J; Krause M
The MADS-Box factor CeMEF2 is not essential for Caenorhabditis elegans myogenesis and development.
Developmental biology 2000;223(2):431-40.
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2000: Kostich M; Fire A; Fambrough D M
Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans.
Journal of cell science 2000;113 ( Pt 14)():2595-606.
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2000: Corsi A K; Kostas S A; Fire A; Krause M
Caenorhabditis elegans twist plays an essential role in non-striated muscle development.
Development (Cambridge, England) 2000;127(10):2041-51.
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2000: Hsieh J; Fire A
Recognition and silencing of repeated DNA.
Annual review of genetics 2000;34():187-204.
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1999: Hsieh J; Liu J; Kostas S A; Chang C; Sternberg P W; Fire A
The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans.
Genes & development 1999;13(22):2958-70.
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1999: Tabara H; Sarkissian M; Kelly W G; Fleenor J; Grishok A; Timmons L; Fire A; Mello C C
The rde-1 gene, RNA interference, and transposon silencing in C. elegans.
Cell 1999;99(2):123-32.
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1999: Fire A
RNA-triggered gene silencing.
Trends in genetics : TIG 1999;15(9):358-63.
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1999: Miller D M; Desai N S; Hardin D C; Piston D W; Patterson G H; Fleenor J; Xu S; Fire A
Two-color GFP expression system for C. elegans.
BioTechniques 1999;26(5):914-8, 920-1.
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1999: Zhang J M; Chen L; Krause M; Fire A; Paterson B M
Evolutionary conservation of MyoD function and differential utilization of E proteins.
Developmental biology 1999;208(2):465-72.
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1998: Montgomery M K; Xu S; Fire A
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15502-7.
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1998: Timmons L; Fire A
Specific interference by ingested dsRNA.
Nature 1998;395(6705):854.
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1998: Harfe B D; Vaz Gomes A; Kenyon C; Liu J; Krause M; Fire A
Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning.
Genes & development 1998;12(16):2623-35.
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1998: Montgomery M K; Fire A
Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression.
Trends in genetics : TIG 1998;14(7):255-8.
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1998: Harfe B D; Branda C S; Krause M; Stern M J; Fire A
MyoD and the specification of muscle and non-muscle fates during postembryonic development of the C. elegans mesoderm.
Development (Cambridge, England) 1998;125(13):2479-88.
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1998: Kelly W G; Fire A
Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans.
Development (Cambridge, England) 1998;125(13):2451-6.
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1998: Fire A; Xu S; Montgomery M K; Kostas S A; Driver S E; Mello C C
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.
Nature 1998;391(6669):806-11.
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1998: Harfe B D; Fire A
Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegans.
Development (Cambridge, England) 1998;125(3):421-9.
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1997: Harbinder S; Tavernarakis N; Herndon L A; Kinnell M; Xu S Q; Fire A; Driscoll M
Genetically targeted cell disruption in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13128-33.
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1997: Okkema P G; Ha E; Haun C; Chen W; Fire A
The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development.
Development (Cambridge, England) 1997;124(20):3965-73.
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1997: Fleming J T; Squire M D; Barnes T M; Tornoe C; Matsuda K; Ahnn J; Fire A; Sulston J E; Barnard E A; Sattelle D B; Lewis J A
Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(15):5843-57.
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1997: Krause M; Park M; Zhang J M; Yuan J; Harfe B; Xu S Q; Greenwald I; Cole M; Paterson B; Fire A
A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development.
Development (Cambridge, England) 1997;124(11):2179-89.
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1997: Kelly W G; Xu S; Montgomery M K; Fire A
Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene.
Genetics 1997;146(1):227-38.
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1996: Seydoux G; Mello C C; Pettitt J; Wood W B; Priess J R; Fire A
Repression of gene expression in the embryonic germ lineage of C. elegans.
Nature 1996;382(6593):713-6.
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1996: Mickey K M; Mello C C; Montgomery M K; Fire A; Priess J R
An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.
Development (Cambridge, England) 1996;122(6):1791-8.
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1995: Fire A; Xu S Q
Rolling replication of short DNA circles.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4641-5.
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1995: Mello C; Fire A
DNA transformation.
Methods in cell biology 1995;48():451-82.
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1995: Seydoux G; Fire A
Whole-mount in situ hybridization for the detection of RNA in Caenorhabditis elegans embryos.
Methods in cell biology 1995;48():323-37.
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1994: Krause M; Harrison S W; Xu S Q; Chen L; Fire A
Elements regulating cell- and stage-specific expression of the C. elegans MyoD family homolog hlh-1.
Developmental biology 1994;166(1):133-48.
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1994: Jantsch-Plunger V; Fire A
Combinatorial structure of a body muscle-specific transcriptional enhancer in Caenorhabditis elegans.
The Journal of biological chemistry 1994;269(43):27021-8.
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1994: Seydoux G; Fire A
Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans.
Development (Cambridge, England) 1994;120(10):2823-34.
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1994: Okkema P G; Fire A
The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle.
Development (Cambridge, England) 1994;120(8):2175-86.
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1994: Fire A
A four-dimensional digital image archiving system for cell lineage tracing and retrospective embryology.
Computer applications in the biosciences : CABIOS 1994;10(4):443-7.
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1994: Ahnn J; Fire A
A screen for genetic loci required for body-wall muscle development during embryogenesis in Caenorhabditis elegans.
Genetics 1994;137(2):483-98.
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1994: Chen L; Krause M; Sepanski M; Fire A
The Caenorhabditis elegans MYOD homologue HLH-1 is essential for proper muscle function and complete morphogenesis.
Development (Cambridge, England) 1994;120(6):1631-41.
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1993: Okkema P G; Harrison S W; Plunger V; Aryana A; Fire A
Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans.
Genetics 1993;135(2):385-404.
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1993: Perry M D; Li W; Trent C; Robertson B; Fire A; Hageman J M; Wood W B
Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination.
Genes & development 1993;7(2):216-28.
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1993: Freedman J H; Slice L W; Dixon D; Fire A; Rubin C S
The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression.
The Journal of biological chemistry 1993;268(4):2554-64.
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1992: Fire A
Histochemical techniques for locating Escherichia coli beta-galactosidase activity in transgenic organisms.
Genetic analysis, techniques and applications 1992;9(5-6):151-8.
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1992: Chen L; Krause M; Draper B; Weintraub H; Fire A
Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD homolog hlh-1.
Science (New York, N.Y.) 1992;256(5054):240-3.
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1992: Krause M; Fire A; White-Harrison S; Weintraub H; Tapscott S
Functional conservation of nematode and vertebrate myogenic regulatory factors.
Journal of cell science. Supplement 1992;16():111-5.
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1991: Fire A; Albertson D; Harrison S W; Moerman D G
Production of antisense RNA leads to effective and specific inhibition of gene expression in C. elegans muscle.
Development (Cambridge, England) 1991;113(2):503-14.
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1990: Krause M; Fire A; Harrison S W; Priess J; Weintraub H
CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis.
Cell 1990;63(5):907-19.
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1990: Fire A; Harrison S W; Dixon D
A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans.
Gene 1990;93(2):189-98.
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1990: Fire A; Kondo K; Waterston R
Vectors for low copy transformation of C. elegans.
Nucleic acids research 1990;18(14):4269-70.
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1989: Fire A; Waterston R H
Proper expression of myosin genes in transgenic nematodes.
The EMBO journal 1989;8(11):3419-28.
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1989: Chodosh L A; Fire A; Samuels M; Sharp P A
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro.
The Journal of biological chemistry 1989;264(4):2250-7.
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1984: Fire A; Samuels M; Sharp P A
Interactions between RNA polymerase II, factors, and template leading to accurate transcription.
The Journal of biological chemistry 1984;259(4):2509-16.
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1984: Samuels M; Fire A; Sharp P A
Dinucleotide priming of transcription mediated by RNA polymerase II.
The Journal of biological chemistry 1984;259(4):2517-25.
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1983: Laski F A; Fire A Z; RajBhandary U L; Sharp P A
Characterization of tRNA precursor splicing in mammalian extracts.
The Journal of biological chemistry 1983;258(19):11974-80.
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1983: Manley J L; Fire A; Samuels M; Sharp P A
In vitro transcription: whole-cell extract.
Methods in enzymology 1983;101():568-82.
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1982: Samuels M; Fire A; Sharp P A
Separation and characterization of factors mediating accurate transcription by RNA polymerase II.
The Journal of biological chemistry 1982;257(23):14419-27.
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1981: Fire A; Baker C C; Manley J L; Ziff E B; Sharp P A
In vitro transcription of adenovirus.
Journal of virology 1981;40(3):703-19.
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1981: Crawford N; Fire A; Samuels M; Sharp P A; Baltimore D
Inhibition of transcription factor activity by poliovirus.
Cell 1981;27(3 Pt 2):555-61.
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1980: Manley J L; Fire A; Cano A; Sharp P A; Gefter M L
DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(7):3855-9.
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1980: Sharp P A; Manley J; Fire A; Gefter M
Regulation of adenovirus mRNA synthesis.
Annals of the New York Academy of Sciences 1980;354():1-15.
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