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Richard Firtel

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Dictyostelium

Physiology

Concepts & Ideas

Chemicals & Drugs

Genes & Molecular Sequences

Procedures

Molecular Cloning

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Co-Publications
Name
17
Lee, Susan
14
Meili, Ruedi
12
Devreotes, Peter
8
Sasaki, Atsuo
6
Ma, Hui
6
Mohanty, S
6
Brown, JM
6
Aubry, Laurence
6
Chung, Chang
6
Funamoto, Satoru
6
Gamper, M
5
Hunter, Tony
5
Charest, Pascale
5
Parent, Carole
5
Williams, Jeffrey

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Publications

TOP 3
Ren Yixin; Effler Janet C; Norstrom Melanie; Luo Tianzhi; Firtel Richard A; Iglesias Pablo A; Rock Ronald S; Robinson Douglas N
Mechanosensing through Cooperative Interactions between Myosin II and the Actin Crosslinker Cortexillin I.
Jeon Taeck J; Lee Susan; Weeks Gerald; Firtel Richard A
Regulation of Dictyostelium morphogenesis by RapGAP3.
Para Alessia; Krischke Miriam; Merlot Sylvain; Shen Zhouxin; Oberholzer Michael; Lee Susan; Briggs Steven; Firtel Richard A
Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility.

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All Publications

2009: Ren Yixin; Effler Janet C; Norstrom Melanie; Luo Tianzhi; Firtel Richard A; Iglesias Pablo A; Rock Ronald S; Robinson Douglas N
Mechanosensing through Cooperative Interactions between Myosin II and the Actin Crosslinker Cortexillin I.
Current biology : CB 2009;19(17):1421-8.
2009: Jeon Taeck J; Lee Susan; Weeks Gerald; Firtel Richard A
Regulation of Dictyostelium morphogenesis by RapGAP3.
Developmental biology 2009;328(2):210-20.
2009: Para Alessia; Krischke Miriam; Merlot Sylvain; Shen Zhouxin; Oberholzer Michael; Lee Susan; Briggs Steven; Firtel Richard A
Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility.
Molecular biology of the cell 2009;20(2):699-707.
2009: Sasaki Atsuo T; Firtel Richard A
Spatiotemporal regulation of Ras-GTPases during chemotaxis.
Methods in molecular biology (Clifton, N.J.) 2009;571():333-48.
2008: Zhang Sheng; Charest Pascale G; Firtel Richard A
Spatiotemporal regulation of Ras activity provides directional sensing.
Current biology : CB 2008;18(20):1587-93.
2008: Du Fei; Edwards Kimberly; Shen Zhouxin; Sun Binggang; De Lozanne Arturo; Briggs Steven; Firtel Richard A
Regulation of contractile vacuole formation and activity in Dictyostelium.
The EMBO journal 2008;27(15):2064-76.
2008: Janetopoulos Christopher; Firtel Richard A
Directional sensing during chemotaxis.
FEBS letters 2008;582(14):2075-85.
2008: Araki Tsuyoshi; Langenick Judith; Gamper Marianne; Firtel Richard A; Williams Jeffrey G
Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase.
Development (Cambridge, England) 2008;135(7):1347-53.
2008: Kölsch Verena; Charest Pascale G; Firtel Richard A
The regulation of cell motility and chemotaxis by phospholipid signaling.
Journal of cell science 2008;121(Pt 5):551-9.
2007: Jeon Taeck J; Lee Dai-Jen; Lee Susan; Weeks Gerald; Firtel Richard A
Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells.
The Journal of cell biology 2007;179(5):833-43.
2007: Del Alamo Juan C; Meili Ruedi; Alonso-Latorre Baldomero; Rodríguez-Rodríguez Javier; Aliseda Alberto; Firtel Richard A; Lasheras Juan C
Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13343-8.
2007: Sasaki Atsuo T; Janetopoulos Chris; Lee Susan; Charest Pascale G; Takeda Kosuke; Sundheimer Lauren W; Meili Ruedi; Devreotes Peter N; Firtel Richard A
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility.
The Journal of cell biology 2007;178(2):185-91.
2007: Mendoza Michelle C; Booth Ezgi O; Shaulsky Gad; Firtel Richard A
MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis.
Molecular and cellular biology 2007;27(10):3817-27.
2007: Takeda Kosuke; Sasaki Atsuo T; Ha Hyunjung; Seung Hyun-A; Firtel Richard A
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium.
The Journal of biological chemistry 2007;282(16):11874-84.
2007: Jeon Taeck J; Lee Dai-Jen; Merlot Sylvain; Weeks Gerald; Firtel Richard A
Rap1 controls cell adhesion and cell motility through the regulation of myosin II.
The Journal of cell biology 2007;176(7):1021-33.
2007: Charest Pascale G; Firtel Richard A
Big roles for small GTPases in the control of directed cell movement.
The Biochemical journal 2007;401(2):377-90.
2006: Sasaki Atsuo T; Firtel Richard A
Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.
European journal of cell biology 2006;85(9-10):873-95.
2006: Charest Pascale G; Firtel Richard A
Feedback signaling controls leading-edge formation during chemotaxis.
Current opinion in genetics & development 2006;16(4):339-47.
2006: Mendoza Michelle C; Firtel Richard A
Assaying chemotaxis of Dictyostelium cells.
Methods in molecular biology (Clifton, N.J.) 2006;346():393-405.
2005: Lee Susan; Comer Frank I; Sasaki Atsuo; McLeod Ian X; Duong Yung; Okumura Koichi; Yates John R; Parent Carole A; Firtel Richard A
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.
Molecular biology of the cell 2005;16(10):4572-83.
2005: Mendoza Michelle C; Du Fei; Iranfar Negin; Tang Nan; Ma Hui; Loomis William F; Firtel Richard A
Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.
Molecular and cellular biology 2005;25(17):7839-53.
2005: Myers Scott A; Han Ji W; Lee Yoonsung; Firtel Richard A; Chung Chang Y
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis.
Molecular biology of the cell 2005;16(5):2191-206.
2005: Meili Ruedi; Sasaki Atsuo T; Firtel Richard A
Rho Rocks PTEN.
Nature cell biology 2005;7(4):334-5.
2005: Sasaki Atsuo T; Firtel Richard A
Finding the way: directional sensing and cell polarization through Ras signalling.
Novartis Foundation symposium 2005;269():73-87; discussion 87-91, 223-30.
2004: Lee Susan; Rivero Francisco; Park Kyung Chan; Huang Emerald; Funamoto Satoru; Firtel Richard A
Dictyostelium PAKc is required for proper chemotaxis.
Molecular biology of the cell 2004;15(12):5456-69.
2004: Sasaki Atsuo T; Chun Cheryl; Takeda Kosuke; Firtel Richard A
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement.
The Journal of cell biology 2004;167(3):505-18.
2004: Park Kyung Chan; Rivero Francisco; Meili Ruedi; Lee Susan; Apone Fabio; Firtel Richard A
Rac regulation of chemotaxis and morphogenesis in Dictyostelium.
The EMBO journal 2004;23(21):4177-89.
2004: Kimmel Alan R; Firtel Richard A
Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response.
Current opinion in genetics & development 2004;14(5):540-9.
2004: Chisholm Rex L; Firtel Richard A
Insights into morphogenesis from a simple developmental system.
Nature reviews. Molecular cell biology 2004;5(7):531-41.
2003: Ridley Anne J; Schwartz Martin A; Burridge Keith; Firtel Richard A; Ginsberg Mark H; Borisy Gary; Parsons J Thomas; Horwitz Alan Rick
Cell migration: integrating signals from front to back.
Science (New York, N.Y.) 2003;302(5651):1704-9.
2003: Aubry Laurence; Lee Susan; Ravanel Kissia; Firtel Richard A
The novel ankyrin-repeat containing kinase ARCK-1 acts as a suppressor of the Spalten signaling pathway during Dictyostelium development.
Developmental biology 2003;263(2):308-22.
2003: Sun Binggang; Ma Hui; Firtel Richard A
Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton.
Molecular biology of the cell 2003;14(11):4526-40.
2003: Merlot Sylvain; Meili Ruedi; Pagliarini David J; Maehama Tomohiko; Dixon Jack E; Firtel Richard A
A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi.
The Journal of biological chemistry 2003;278(41):39866-73.
2003: Merlot Sylvain; Firtel Richard A
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways.
Journal of cell science 2003;116(Pt 17):3471-8.
2003: Meili Ruedi; Firtel Richard A
Two poles and a compass.
Cell 2003;114(2):153-6.
2003: Huang Yi Elaine; Iijima Miho; Parent Carole A; Funamoto Satoru; Firtel Richard A; Devreotes Peter
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells.
Molecular biology of the cell 2003;14(5):1913-22.
2003: Sun Binggang; Firtel Richard A
A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in dictyostelium.
Molecular biology of the cell 2003;14(4):1727-43.
2003: Meili Ruedi; Firtel Richard A
Follow the leader.
Developmental cell 2003;4(3):291-3.
2002: Han Young-Hoon; Chung Chang Y; Wessels Deborah; Stephens Stephen; Titus Margaret A; Soll David R; Firtel Richard A
Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium.
The Journal of biological chemistry 2002;277(51):49877-87.
2002: Meili Ruedi; Firtel Richard A
Leading the way.
Nature cell biology 2002;4(7):E171.
2002: Sobko Alex; Ma Hui; Firtel Richard A
Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis.
Developmental cell 2002;2(6):745-56.
2002: Funamoto Satoru; Meili Ruedi; Lee Susan; Parry Lisa; Firtel Richard A
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis.
Cell 2002;109(5):611-23.
2002: Chung Chang Y; Firtel Richard A
Signaling pathways at the leading edge of chemotaxing cells.
Journal of muscle research and cell motility 2002;23(7-8):773-9.
2001: Chung C Y; Funamoto S; Firtel R A
Signaling pathways controlling cell polarity and chemotaxis.
Trends in biochemical sciences 2001;26(9):557-66.
2001: Brown J M; Firtel R A
Functional and regulatory analysis of the dictyostelium G-box binding factor.
Developmental biology 2001;234(2):521-34.
2001: Mohanty S; Lee S; Yadava N; Dealy M J; Johnson R S; Firtel R A
Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium.
Genes & development 2001;15(11):1435-48.
2001: Chung C Y; Potikyan G; Firtel R A
Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa.
Molecular cell 2001;7(5):937-47.
2001: Funamoto S; Milan K; Meili R; Firtel R A
Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium.
The Journal of cell biology 2001;153(4):795-810.
2001: Briscoe C; Moniakis J; Kim J Y; Brown J M; Hereld D; Devreotes P N; Firtel R A
The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation.
Developmental biology 2001;233(1):225-36.
2001: Early A; Gamper M; Moniakis J; Kim E; Hunter T; Williams J G; Firtel R A
Protein tyrosine phosphatase PTP1 negatively regulates Dictyostelium STATa and is required for proper cell-type proportioning.
Developmental biology 2001;232(1):233-45.
2001: Moniakis J; Funamoto S; Fukuzawa M; Meisenhelder J; Araki T; Abe T; Meili R; Hunter T; Williams J; Firtel R A
An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway.
Genes & development 2001;15(6):687-98.
2000: Nelson M K; Clark A; Abe T; Nomura A; Yadava N; Funair C J; Jermyn K A; Mohanty S; Firtel R A; Williams J G
An F-Box/WD40 repeat-containing protein important for Dictyostelium cell-type proportioning, slug behaviour, and culmination.
Developmental biology 2000;224(1):42-59.
2000: Firtel R A; Meili R
Dictyostelium: a model for regulated cell movement during morphogenesis.
Current opinion in genetics & development 2000;10(4):421-7.
2000: Firtel R A; Chung C Y
The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(7):603-15.
2000: Meili R; Ellsworth C; Firtel R A
A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium.
Current biology : CB 2000;10(12):708-17.
2000: Chung C Y; Lee S; Briscoe C; Ellsworth C; Firtel R A
Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5225-30.
2000: Brown J M; Firtel R A
Just the right size: cell counting in Dictyostelium.
Trends in genetics : TIG 2000;16(5):191-3.
2000: Chien S; Chung C Y; Sukumaran S; Osborne N; Lee S; Ellsworth C; McNally J G; Firtel R A
The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis.
Molecular biology of the cell 2000;11(4):1275-91.
1999: Mohanty S; Firtel R A
Control of spatial patterning and cell-type proportioning in Dictyostelium.
Seminars in cell & developmental biology 1999;10(6):597-607.
1999: Chung C Y; Firtel R A
PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis.
The Journal of cell biology 1999;147(3):559-76.
1999: Lee S; Parent C A; Insall R; Firtel R A
A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.
Molecular biology of the cell 1999;10(9):2829-45.
1999: Mohanty S; Jermyn K A; Early A; Kawata T; Aubry L; Ceccarelli A; Schaap P; Williams J G; Firtel R A
Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis.
Development (Cambridge, England) 1999;126(15):3391-405.
1999: Gamper M; Kim E; Howard P K; Ma H; Hunter T; Firtel R A
Regulation of Dictyostelium protein-tyrosine phosphatase-3 (PTP3) through osmotic shock and stress stimulation and identification of pp130 as a PTP3 substrate.
The Journal of biological chemistry 1999;274(17):12129-38.
1999: Meili R; Ellsworth C; Lee S; Reddy T B; Ma H; Firtel R A
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium.
The EMBO journal 1999;18(8):2092-105.
1999: Aubry L; Firtel R
Integration of signaling networks that regulate Dictyostelium differentiation.
Annual review of cell and developmental biology 1999;15():469-517.
1998: Chung C Y; Reddy T B; Zhou K; Firtel R A
A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation.
Genes & development 1998;12(22):3564-78.
1998: Brown J M; Firtel R A
Phosphorelay signalling: new tricks for an ancient pathway.
Current biology : CB 1998;8(18):R662-5.
1998: Sukumaran S; Brown J M; Firtel R A; McNally J G
lagC-null and gbf-null cells define key steps in the morphogenesis of Dictyostelium mounds.
Developmental biology 1998;200(1):16-26.
1998: Araki T; Gamper M; Early A; Fukuzawa M; Abe T; Kawata T; Kim E; Firtel R A; Williams J G
Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor.
The EMBO journal 1998;17(14):4018-28.
1998: Yasukawa H; Mohanty S; Firtel R A
Identification and analysis of a gene that is essential for morphogenesis and prespore cell differentiation in Dictyostelium.
Development (Cambridge, England) 1998;125(14):2565-76.
1998: Aubry L; Firtel R A
Spalten, a protein containing Galpha-protein-like and PP2C domains, is essential for cell-type differentiation in Dictyostelium.
Genes & development 1998;12(10):1525-38.
1998: Cubitt A B; Reddy I; Lee S; McNally J G; Firtel R A
Coexpression of a constitutively active plasma membrane calcium pump with GFP identifies roles for intracellular calcium in controlling cell sorting during morphogenesis in Dictyostelium.
Developmental biology 1998;196(1):77-94.
1998: Han Z; Firtel R A
The homeobox-containing gene Wariai regulates anterior-posterior patterning and cell-type homeostasis in Dictyostelium.
Development (Cambridge, England) 1998;125(2):313-25.
1997: Clark A; Nomura A; Mohanty S; Firtel R A
A ubiquitin-conjugating enzyme is essential for developmental transitions in Dictyostelium.
Molecular biology of the cell 1997;8(10):1989-2002.
1997: Ma H; Gamper M; Parent C; Firtel R A
The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase.
The EMBO journal 1997;16(14):4317-32.
1997: Mann S K; Brown J M; Briscoe C; Parent C; Pitt G; Devreotes P N; Firtel R A
Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.
Developmental biology 1997;183(2):208-21.
1997: Lee S; Escalante R; Firtel R A
A Ras GAP is essential for cytokinesis and spatial patterning in Dictyostelium.
Development (Cambridge, England) 1997;124(5):983-96.
1997: Aubry L; Maeda M; Insall R; Devreotes P N; Firtel R A
The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function.
The Journal of biological chemistry 1997;272(7):3883-6.
1996: Firtel R A
Interacting signaling pathways controlling multicellular development in Dictyostelium.
Current opinion in genetics & development 1996;6(5):545-54.
1996: Gamper M; Howard P K; Hunter T; Firtel R A
Multiple roles of the novel protein tyrosine phosphatase PTP3 during Dictyostelium growth and development.
Molecular and cellular biology 1996;16(5):2431-44.
1996: Hadwiger J A; Natarajan K; Firtel R A
Mutations in the Dictyostelium heterotrimeric G protein alpha subunit G alpha5 alter the kinetics of tip morphogenesis.
Development (Cambridge, England) 1996;122(4):1215-24.
1996: Maeda M; Aubry L; Insall R; Gaskins C; Devreotes P N; Firtel R A
Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins.
The Journal of biological chemistry 1996;271(7):3351-4.
1996: Gaskins C; Clark A M; Aubry L; Segall J E; Firtel R A
The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways.
Genes & development 1996;10(1):118-28.
1995: Zhou K; Takegawa K; Emr S D; Firtel R A
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development.
Molecular and cellular biology 1995;15(10):5645-56.
1995: Schnitzler G R; Briscoe C; Brown J M; Firtel R A
Serpentine cAMP receptors may act through a G protein-independent pathway to induce postaggregative development in Dictyostelium.
Cell 1995;81(5):737-45.
1995: Firtel R A
Integration of signaling information in controlling cell-fate decisions in Dictyostelium.
Genes & development 1995;9(12):1427-44.
1995: Cao J G; Firtel R A
Growth and developmental functions of a human immunodeficiency virus Tat-binding protein/26S protease subunit homolog from Dictyostelium discoideum.
Molecular and cellular biology 1995;15(3):1725-36.
1995: Briscoe C; Firtel R A
Intercellular signaling. A kinase for cell-fate determination?
Current biology : CB 1995;5(3):228-31.
1995: Segall J E; Kuspa A; Shaulsky G; Ecke M; Maeda M; Gaskins C; Firtel R A; Loomis W F
A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.
The Journal of cell biology 1995;128(3):405-13.
1994: Dharmawardhane S; Cubitt A B; Clark A M; Firtel R A
Regulatory role of the G alpha 1 subunit in controlling cellular morphogenesis in Dictyostelium.
Development (Cambridge, England) 1994;120(12):3549-61.
1994: Hori R; Firtel R A
Identification and characterization of multiple A/T-rich cis-acting elements that control expression from Dictyostelium actin promoters: the Dictyostelium actin upstream activating sequence confers growth phase expression and has enhancer-like properties.
Nucleic acids research 1994;22(23):5099-111.
1994: Hadwiger J A; Lee S; Firtel R A
The G alpha subunit G alpha 4 couples to pterin receptors and identifies a signaling pathway that is essential for multicellular development in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10566-70.
1994: Mann S K; Richardson D L; Lee S; Kimmel A R; Firtel R A
Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10561-5.
1994: Gaskins C; Maeda M; Firtel R A
Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum.
Molecular and cellular biology 1994;14(10):6996-7012.
1994: Powell-Coffman J A; Schnitzler G R; Firtel R A
A GBF-binding site and a novel AT element define the minimal sequences sufficient to direct prespore-specific expression in Dictyostelium discoideum.
Molecular and cellular biology 1994;14(9):5840-9.
1994: Howard P K; Gamper M; Hunter T; Firtel R A
Regulation by protein-tyrosine phosphatase PTP2 is distinct from that by PTP1 during Dictyostelium growth and development.
Molecular and cellular biology 1994;14(8):5154-64.
1994: Powell-Coffman J A; Firtel R A
Characterization of a novel Dictyostelium discoideum prespore-specific gene, PspB, reveals conserved regulatory sequences.
Development (Cambridge, England) 1994;120(6):1601-11.
1994: Wu L; Gaskins C; Zhou K; Firtel R A; Devreotes P N
Cloning and targeted mutations of G alpha 7 and G alpha 8, two developmentally regulated G protein alpha-subunit genes in Dictyostelium.
Molecular biology of the cell 1994;5(6):691-702.
1994: Dynes J L; Clark A M; Shaulsky G; Kuspa A; Loomis W F; Firtel R A
LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium.
Genes & development 1994;8(8):948-58.
1994: Schnitzler G R; Fischer W H; Firtel R A
Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium.
Genes & development 1994;8(4):502-14.
1994: Carrel F; Dharmawardhane S; Clark A M; Powell-Coffman J A; Firtel R A
Spatial and temporal expression of the Dictyostelium discoideum G alpha protein subunit G alpha 2: expression of a dominant negative protein inhibits proper prestalk to stalk differentiation.
Molecular biology of the cell 1994;5(1):7-16.
1993: Mann S K; Firtel R A
cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development.
Development (Cambridge, England) 1993;119(1):135-46.
1993: Cubitt A B; Dharmawardhane S; Firtel R A
Developmentally regulated changes in 1,2-diacylglycerol in Dictyostelium. Regulation by light and G proteins.
The Journal of biological chemistry 1993;268(23):17431-9.
1993: Howard P K; Sefton B M; Firtel R A
Tyrosine phosphorylation of actin in Dictyostelium associated with cell-shape changes.
Science (New York, N.Y.) 1993;259(5092):241-4.
1992: Howard P K; Sefton B M; Firtel R A
Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium.
Cell 1992;71(4):637-47.
1992: Mann S K; Yonemoto W M; Taylor S S; Firtel R A
DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10701-5.
1992: Okaichi K; Cubitt A B; Pitt G S; Firtel R A
Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.
Molecular biology of the cell 1992;3(7):735-47.
1992: Powell J A; Galindo J; Firtel R A
A negative transcriptional control region of a developmentally-regulated gene co-localizes with the origin of replication of an endogenous plasmid in Dictyostelium.
Nucleic acids research 1992;20(11):2795-802.
1992: Cubitt A B; Firtel R A
Characterization of phospholipase activity in Dictyostelium discoideum. Identification of a Ca(2+)-dependent polyphosphoinositide-specific phospholipase C.
The Biochemical journal 1992;283 ( Pt 2)():371-8.
1992: Esch R K; Howard P K; Firtel R A
Regulation of the Dictyostelium cAMP-induced, prestalk-specific DdrasD gene: identification of cis-acting elements.
Nucleic acids research 1992;20(6):1325-32.
1992: Hadwiger J A; Firtel R A
Analysis of G alpha 4, a G-protein subunit required for multicellular development in Dictyostelium.
Genes & development 1992;6(1):38-49.
1992: Cubitt A B; Carrel F; Dharmawardhane S; Gaskins C; Hadwiger J; Howard P; Mann S K; Okaichi K; Zhou K; Firtel R A
Molecular genetic analysis of signal transduction pathways controlling multicellular development in Dictyostelium.
Cold Spring Harbor symposia on quantitative biology 1992;57():177-92.
1991: Haberstroh L; Galindo J; Firtel R A
Developmental and spatial regulation of a Dictyostelium prespore gene: cis-acting elements and a cAMP-induced, developmentally regulated DNA binding activity.
Development (Cambridge, England) 1991;113(3):947-58.
1991: Firtel R A
Signal transduction pathways controlling multicellular development in Dictyostelium.
Trends in genetics : TIG 1991;7(11-12):381-8.
1991: Hadwiger J A; Wilkie T M; Strathmann M; Firtel R A
Identification of Dictyostelium G alpha genes expressed during multicellular development.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8213-7.
1991: Mann S K; Firtel R A
A developmentally regulated, putative serine/threonine protein kinase is essential for development in Dictyostelium.
Mechanisms of development 1991;35(2):89-101.
1991: Gomer R H; Yuen I S; Firtel R A
A secreted 80 x 10(3) Mr protein mediates sensing of cell density and the onset of development in Dictyostelium.
Development (Cambridge, England) 1991;112(1):269-78.
1991: Firtel R A
Putting the G in development.
Current biology : CB 1991;1(2):91-3.
1991: Esch R K; Firtel R A
cAMP and cell sorting control the spatial expression of a developmentally essential cell-type-specific ras gene in Dictyostelium.
Genes & development 1991;5(1):9-21.
1991: Kumagai A; Hadwiger J A; Pupillo M; Firtel R A
Molecular genetic analysis of two G alpha protein subunits in Dictyostelium.
The Journal of biological chemistry 1991;266(2):1220-8.
1990: Haberstroh L; Firtel R A
A spatial gradient of expression of a cAMP-regulated prespore cell-type-specific gene in Dictyostelium.
Genes & development 1990;4(4):596-612.
1990: Hjorth A L; Pears C; Williams J G; Firtel R A
A developmentally regulated trans-acting factor recognizes dissimilar G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes.
Genes & development 1990;4(3):419-32.
1990: Firtel R A; Chapman A L
A role for cAMP-dependent protein kinase A in early Dictyostelium development.
Genes & development 1990;4(1):18-28.
1989: Dynes J L; Firtel R A
Molecular complementation of a genetic marker in Dictyostelium using a genomic DNA library.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7966-70.
1989: Firtel R A; van Haastert P J; Kimmel A R; Devreotes P N
G protein linked signal transduction pathways in development: dictyostelium as an experimental system.
Cell 1989;58(2):235-9.
1989: Pupillo M; Kumagai A; Pitt G S; Firtel R A; Devreotes P N
Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4892-6.
1989: Hjorth A L; Khanna N C; Firtel R A
A trans-acting factor required for cAMP-induced gene expression in Dictyostelium is regulated developmentally and induced by cAMP.
Genes & development 1989;3(6):747-59.
1989: Kumagai A; Pupillo M; Gundersen R; Miake-Lye R; Devreotes P N; Firtel R A
Regulation and function of G alpha protein subunits in Dictyostelium.
Cell 1989;57(2):265-75.
1989: Mann S K; Firtel R A
Two-phase regulatory pathway controls cAMP receptor-mediated expression of early genes in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(6):1924-8.
1989: Rubino S; Mann S K; Hori R T; Pinko C; Firtel R A
Molecular analysis of a developmentally regulated gene required for Dictyostelium aggregation.
Developmental biology 1989;131(1):27-36.
1988: Mann S K; Pinko C; Firtel R A
Regulation of Dictyostelium early gene expression in cAMP bypass mutants.
Developmental biology 1988;130(1):406-10.
1988: Mann S K; Pinko C; Firtel R A
cAMP regulation of early gene expression in signal transduction mutants of Dictyostelium.
Developmental biology 1988;130(1):294-303.
1988: Ahern K G; Howard P K; Firtel R A
Identification of regions essential for extrachromosomal replication and maintenance of an endogenous plasmid in Dictyostelium.
Nucleic acids research 1988;16(14B):6825-37.
1988: Howard P K; Ahern K G; Firtel R A
Establishment of a transient expression system for Dictyostelium discoideum.
Nucleic acids research 1988;16(6):2613-23.
1988: Datta S; Firtel R A
An 80-bp cis-acting regulatory region controls cAMP and development regulation of a prestalk gene in Dictyostelium.
Genes & development 1988;2(3):294-304.
1988: Kumagai A; Mann S K; Pupillo M; Pitt G; Devreotes P N; Firtel R A
A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():675-85.
1988: Pupillo M; Klein P; Vaughan R; Pitt G; Lilly P; Sun T; Devreotes P; Kumagai A; Firtel R
cAMP receptor and G-protein interactions control development in Dictyostelium.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():657-65.
1988: Hjorth A; Datta S; Khanna N C; Firtel R A
Analysis of cis and trans elements involved in cAMP-inducible gene expression in Dictyostelium discoideum.
Developmental genetics 1988;9(4-5):435-54.
1988: Mann S K; Pinko C; Firtel R A
Control of early gene expression in Dictyostelium.
Developmental genetics 1988;9(4-5):337-50.
1986: Saxe C L; Firtel R A
Regulation of late gene expression in a temperature-sensitive cohesion-defective mutant of Dictyostelium discoideum.
Developmental genetics 1986;7(2):99-108.

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