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Richard Firtel

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Verena Kölsch; Arjan Kortholt; Susan Lee; Pouya Lotfi; Katarzyna Plak; Jesus Lacal Romero; Zhouxin Shen; Steven P Briggs; Jessica Chang; Pascale G Charest; Taeck J Jeon; Richard A Firtel
Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility.
Wouter-Jan Rappel; Richard A Firtel
Adaptation in a eukaryotic pathway: combining experiments with modeling.
Effie Bastounis; Juan C del Álamo; Juan C Lasheras; ruedi meili; Baldomero Alonso-Latorre; Richard A Firtel
The SCAR/WAVE complex is necessary for proper regulation of traction stresses during amoeboid motility.

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All Publications

2013: Verena Kölsch; Arjan Kortholt; Susan Lee; Pouya Lotfi; Katarzyna Plak; Jesus Lacal Romero; Zhouxin Shen; Steven P Briggs; Jessica Chang; Pascale G Charest; Taeck J Jeon; Richard A Firtel
Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility.
Molecular biology of the cell 2013;24(2):100-14.
2012: Wouter-Jan Rappel; Richard A Firtel
Adaptation in a eukaryotic pathway: combining experiments with modeling.
Cell cycle (Georgetown, Tex.) 2012;11(6):1051-2.
2011: Effie Bastounis; Juan C del Álamo; Juan C Lasheras; ruedi meili; Baldomero Alonso-Latorre; Richard A Firtel
The SCAR/WAVE complex is necessary for proper regulation of traction stresses during amoeboid motility.
Molecular biology of the cell 2011;22(21):3995-4003.
2011: Sebastian Kicka; Susan Lee; Zhouxin Shen; Sarah J Annesley; Steven Briggs; Paul R Fisher; Richard A Firtel
The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton.
Molecular biology of the cell 2011;22(13):2198-211.
2011: Inbal Hecht; Herbert Levine; William F Loomis; Eshel Ben-Jacob; Pascale G Charest; Richard A Firtel; Monica Skoge; Wouter-Jan Rappel
Activated membrane patches guide chemotactic cell motility.
PLoS computational biology 2011;7(6):e1002044.
2010: Pascale G Charest; Richard A Firtel
"TORCing" neutrophil chemotaxis.
Developmental cell 2010;19(6):795-6.
2010: Susan Lee; Zhouxin Shen; Douglas Robinson; Steven Briggs; Richard A Firtel
Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis.
Molecular biology of the cell 2010;21(11):1810-24.
2010: Pascale G Charest; Zhouxin Shen; Ashley Lakoduk; Atsuo Sasaki; Steven P Briggs; Richard A Firtel
A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration.
Developmental cell 2010;18(5):737-49.
2010: ruedi meili; Baldomero Alonso-Latorre; Juan C del Alamo; Richard A Firtel; Juan C Lasheras
Myosin II is essential for the spatiotemporal organization of traction forces during cell motility.
Molecular biology of the cell 2010;21(3):405-17.
2009: Yixin Ren; Janet C Effler; Melanie Norstrom; Tianzhi Luo; Richard A Firtel; Pablo A Iglesias; Ronald S Rock; Douglas Robinson
Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I.
Current biology : CB 2009;19(17):1421-8.
2009: Taeck J Jeon; Susan Lee; Gerald Weeks; Richard A Firtel
Regulation of Dictyostelium morphogenesis by RapGAP3.
Developmental biology 2009;328(2):210-20.
2009: B Alonso-Latorre; ruedi meili; E Bastounis; J C Del Alamo; Richard A Firtel; Juan C Lasheras
Distribution of traction forces associated with shape changes during amoeboid cell migration.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2009;2009():3346-9.
2009: Atsuo Sasaki; Richard A Firtel
Spatiotemporal regulation of Ras-GTPases during chemotaxis.
Methods in molecular biology (Clifton, N.J.) 2009;571():333-48.
2009: Alessia Para; Miriam Krischke; Sylvain Merlot; Zhouxin Shen; Michael Oberholzer; Susan Lee; Steven Briggs; Richard A Firtel
Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility.
Molecular biology of the cell 2009;20(2):699-707.
2008: Sheng Zhang; Pascale G Charest; Richard A Firtel
Spatiotemporal regulation of Ras activity provides directional sensing.
Current biology : CB 2008;18(20):1587-93.
2008: Fei Du; Kimberly Edwards; Zhouxin Shen; Binggang Sun; Arturo De Lozanne; Steven Briggs; Richard A Firtel
Regulation of contractile vacuole formation and activity in Dictyostelium.
The EMBO journal 2008;27(15):2064-76.
2008: Chris Janetopoulos; Richard A Firtel
Directional sensing during chemotaxis.
FEBS letters 2008;582(14):2075-85.
2008: Tsuyoshi Araki; Judith Langenick; Marianne Gamper; Richard A Firtel; Jeffrey G Williams
Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase.
Development (Cambridge, England) 2008;135(7):1347-53.
2008: Verena Kölsch; Pascale G Charest; Richard A Firtel
The regulation of cell motility and chemotaxis by phospholipid signaling.
Journal of cell science 2008;121(Pt 5):551-9.
2007: Taeck J Jeon; Dai-Jen Lee; Susan Lee; Gerald Weeks; Richard A Firtel
Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells.
The Journal of cell biology 2007;179(5):833-43.
2007: Juan C Del Alamo; ruedi meili; Baldomero Alonso-Latorre; Javier Rodríguez-Rodríguez; Alberto Aliseda; Richard A Firtel; Juan C Lasheras
Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13343-8.
2007: Atsuo Sasaki; Chris Janetopoulos; Susan Lee; Pascale G Charest; Kosuke Takeda; Lauren W Sundheimer; ruedi meili; Peter N Devreotes; Richard A Firtel
G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility.
The Journal of cell biology 2007;178(2):185-91.
2007: Michelle C Mendoza; Ezgi Boothq; Gad Shaulsky; Richard A Firtel
MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis.
Molecular and cellular biology 2007;27(10):3817-27.
2007: Kosuke Takeda; Atsuo Sasaki; Hyunjung Ha; Hyun-A Seung; Richard A Firtel
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium.
The Journal of biological chemistry 2007;282(16):11874-84.
2007: Taeck J Jeon; Dai-Jen Lee; Sylvain Merlot; Gerald Weeks; Richard A Firtel
Rap1 controls cell adhesion and cell motility through the regulation of myosin II.
The Journal of cell biology 2007;176(7):1021-33.
2007: Pascale G Charest; Richard A Firtel
Big roles for small GTPases in the control of directed cell movement.
The Biochemical journal 2007;401(2):377-90.
2006: Atsuo Sasaki; Richard A Firtel
Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.
European journal of cell biology 2006;85(9-10):873-95.
2006: Pascale G Charest; Richard A Firtel
Feedback signaling controls leading-edge formation during chemotaxis.
Current opinion in genetics & development 2006;16(4):339-47.
2006: Michelle C Mendoza; Richard A Firtel
Assaying chemotaxis of Dictyostelium cells.
Methods in molecular biology (Clifton, N.J.) 2006;346():393-405.
2005: Susan Lee; Frank I Comer; Atsuo Sasaki; Ian X McLeod; Yung Duong; Koichi Okumura; John R Yates; Carole A Parent; Richard A Firtel
TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.
Molecular biology of the cell 2005;16(10):4572-83.
2005: Michelle C Mendoza; Fei Du; Negin Iranfar; Nan Tang; Hui Ma; William F Loomis; Richard A Firtel
Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.
Molecular and cellular biology 2005;25(17):7839-53.
2005: Scott A Myers; Ji W Han; Yoonsung Lee; Richard A Firtel; Chang Y Chung
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis.
Molecular biology of the cell 2005;16(5):2191-206.
2005: ruedi meili; Atsuo Sasaki; Richard A Firtel
Rho Rocks PTEN.
Nature cell biology 2005;7(4):334-5.
2005: Atsuo Sasaki; Richard A Firtel
Finding the way: directional sensing and cell polarization through Ras signalling.
Novartis Foundation symposium 2005;269():73-87; discussion 87-91, 223-30.
2004: Susan Lee; Francisco Rivero; Kyung Chan Park; Emerald Huang; Satoru Funamoto; Richard A Firtel
Dictyostelium PAKc is required for proper chemotaxis.
Molecular biology of the cell 2004;15(12):5456-69.
2004: Atsuo Sasaki; Cheryl Chun; Kosuke Takeda; Richard A Firtel
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement.
The Journal of cell biology 2004;167(3):505-18.
2004: Kyung Chan Park; Francisco Rivero; ruedi meili; Susan Lee; Fabio Apone; Richard A Firtel
Rac regulation of chemotaxis and morphogenesis in Dictyostelium.
The EMBO journal 2004;23(21):4177-89.
2004: Alan R Kimmel; Richard A Firtel
Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response.
Current opinion in genetics & development 2004;14(5):540-9.
2004: Rex Chisholm; Richard A Firtel
Insights into morphogenesis from a simple developmental system.
Nature reviews. Molecular cell biology 2004;5(7):531-41.
2003: Anne J Ridley; Martin A Schwartz; Keith Burridge; Richard A Firtel; Mark H Ginsberg; Gary G Borisy; Thomas J Parsons; Alan Rick Horwitz
Cell migration: integrating signals from front to back.
Science (New York, N.Y.) 2003;302(5651):1704-9.
2003: Laurence Aubry; Susan Lee; Kissia Ravanel; Richard A Firtel
The novel ankyrin-repeat containing kinase ARCK-1 acts as a suppressor of the Spalten signaling pathway during Dictyostelium development.
Developmental biology 2003;263(2):308-22.
2003: Binggang Sun; Hui Ma; Richard A Firtel
Dictyostelium stress-activated protein kinase alpha, a novel stress-activated mitogen-activated protein kinase kinase kinase-like kinase, is important for the proper regulation of the cytoskeleton.
Molecular biology of the cell 2003;14(11):4526-40.
2003: Sylvain Merlot; ruedi meili; David J Pagliarini; Tomohiko Maehama; Jack E Dixon; Richard A Firtel
A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi.
The Journal of biological chemistry 2003;278(41):39866-73.
2003: Sylvain Merlot; Richard A Firtel
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways.
Journal of cell science 2003;116(Pt 17):3471-8.
2003: ruedi meili; Richard A Firtel
Two poles and a compass.
Cell 2003;114(2):153-6.
2003: Yi Elaine Huang; Miho Iijima; Carole A Parent; Satoru Funamoto; Richard A Firtel; Peter N Devreotes
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells.
Molecular biology of the cell 2003;14(5):1913-22.
2003: Binggang Sun; Richard A Firtel
A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in dictyostelium.
Molecular biology of the cell 2003;14(4):1727-43.
2003: ruedi meili; Richard A Firtel
Follow the leader.
Developmental cell 2003;4(3):291-3.
2002: Young-Hoon Han; Chang Y Chung; Deborah Wessels; Stephen Stephens; Margaret A Titus; David Soll; Richard A Firtel
Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium.
The Journal of biological chemistry 2002;277(51):49877-87.
2002: ruedi meili; Richard A Firtel
Leading the way.
Nature cell biology 2002;4(7):E171.
2002: Alex Sobko; Hui Ma; Richard A Firtel
Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis.
Developmental cell 2002;2(6):745-56.
2002: Satoru Funamoto; ruedi meili; Susan Lee; Lisa Parry; Richard A Firtel
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis.
Cell 2002;109(5):611-23.
2002: Chang Y Chung; Richard A Firtel
Signaling pathways at the leading edge of chemotaxing cells.
Journal of muscle research and cell motility 2002;23(7-8):773-9.
2001: C Y Chung; Satoru Funamoto; Richard A Firtel
Signaling pathways controlling cell polarity and chemotaxis.
Trends in biochemical sciences 2001;26(9):557-66.
2001: JM Brown; Richard A Firtel
Functional and regulatory analysis of the dictyostelium G-box binding factor.
Developmental biology 2001;234(2):521-34.
2001: S Mohanty; Susan Lee; Nagendra Yadava; M J Dealy; R S Johnson; Richard A Firtel
Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium.
Genes & development 2001;15(11):1435-48.
2001: Satoru Funamoto; K Milan; ruedi meili; Richard A Firtel
Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium.
The Journal of cell biology 2001;153(4):795-810.
2001: C Y Chung; G Potikyan; Richard A Firtel
Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa.
Molecular cell 2001;7(5):937-47.
2001: C Briscoe; J Moniakis; J Y Kim; JM Brown; D Hereld; Peter N Devreotes; Richard A Firtel
The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation.
Developmental biology 2001;233(1):225-36.
2001: A Early; M Gamper; J Moniakis; E Kim; Tony Hunter; Jeffrey G Williams; Richard A Firtel
Protein tyrosine phosphatase PTP1 negatively regulates Dictyostelium STATa and is required for proper cell-type proportioning.
Developmental biology 2001;232(1):233-45.
2001: J Moniakis; Satoru Funamoto; M Fukuzawa; J Meisenhelder; T Araki; T Abe; ruedi meili; Tony Hunter; J Williams; Richard A Firtel
An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathway.
Genes & development 2001;15(6):687-98.
2000: M K Nelson; A Clark; Tomoaki Abe; A Nomura; Nagendra Yadava; C J Funair; Keith A Jermyn; S Mohanty; Richard A Firtel; Jeffrey G Williams
An F-Box/WD40 repeat-containing protein important for Dictyostelium cell-type proportioning, slug behaviour, and culmination.
Developmental biology 2000;224(1):42-59.
2000: Richard A Firtel; ruedi meili
Dictyostelium: a model for regulated cell movement during morphogenesis.
Current opinion in genetics & development 2000;10(4):421-7.
2000: Richard A Firtel; Chang Y Chung
The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(7):603-15.
2000: ruedi meili; C Ellsworth; Richard A Firtel
A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium.
Current biology : CB 2000;10(12):708-17.
2000: Chang Y Chung; Susan Lee; C Briscoe; C Ellsworth; Richard A Firtel
Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5225-30.
2000: JM Brown; Richard A Firtel
Just the right size: cell counting in Dictyostelium.
Trends in genetics : TIG 2000;16(5):191-3.
2000: S Chien; Chang Y Chung; S Sukumaran; N Osborne; Susan Lee; C Ellsworth; JG McNally; Richard A Firtel
The Dictyostelium LIM domain-containing protein LIM2 is essential for proper chemotaxis and morphogenesis.
Molecular biology of the cell 2000;11(4):1275-91.
1999: S Mohanty; Richard A Firtel
Control of spatial patterning and cell-type proportioning in Dictyostelium.
Seminars in cell & developmental biology 1999;10(6):597-607.
1999: Chang Y Chung; Richard A Firtel
PAKa, a putative PAK family member, is required for cytokinesis and the regulation of the cytoskeleton in Dictyostelium discoideum cells during chemotaxis.
The Journal of cell biology 1999;147(3):559-76.
1999: Susan Lee; Carole A Parent; R Insall; Richard A Firtel
A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium.
Molecular biology of the cell 1999;10(9):2829-45.
1999: S Mohanty; Keith A Jermyn; A Early; Takefumi Kawata; Laurence Aubry; A Ceccarelli; P Schaap; Jeffrey G Williams; Richard A Firtel
Evidence that the Dictyostelium Dd-STATa protein is a repressor that regulates commitment to stalk cell differentiation and is also required for efficient chemotaxis.
Development (Cambridge, England) 1999;126(15):3391-405.
1999: M Gamper; E Kim; P K Howard; Hui Ma; Tony Hunter; Richard A Firtel
Regulation of Dictyostelium protein-tyrosine phosphatase-3 (PTP3) through osmotic shock and stress stimulation and identification of pp130 as a PTP3 substrate.
The Journal of biological chemistry 1999;274(17):12129-38.
1999: ruedi meili; C Ellsworth; Susan Lee; T B Reddy; Hui Ma; Richard A Firtel
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium.
The EMBO journal 1999;18(8):2092-105.
1999: L Aubry; Richard A Firtel
Integration of signaling networks that regulate Dictyostelium differentiation.
Annual review of cell and developmental biology 1999;15():469-517.
1998: Chang Y Chung; T B Reddy; K Zhou; Richard A Firtel
A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation.
Genes & development 1998;12(22):3564-78.
1998: JM Brown; Richard A Firtel
Phosphorelay signalling: new tricks for an ancient pathway.
Current biology : CB 1998;8(18):R662-5.
1998: S Sukumaran; J M Brown; Richard A Firtel; JG McNally
lagC-null and gbf-null cells define key steps in the morphogenesis of Dictyostelium mounds.
Developmental biology 1998;200(1):16-26.
1998: T Araki; M Gamper; A Early; Masashi Fukuzawa; T Abe; Takefumi Kawata; E Kim; Richard A Firtel; Jeffrey G Williams
Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor.
The EMBO journal 1998;17(14):4018-28.
1998: Hideo Yasukawa; S Mohanty; Richard A Firtel
Identification and analysis of a gene that is essential for morphogenesis and prespore cell differentiation in Dictyostelium.
Development (Cambridge, England) 1998;125(14):2565-76.
1998: Laurence Aubry; Richard A Firtel
Spalten, a protein containing Galpha-protein-like and PP2C domains, is essential for cell-type differentiation in Dictyostelium.
Genes & development 1998;12(10):1525-38.
1998: A B Cubitt; I Reddy; Susan Lee; JG McNally; Richard A Firtel
Coexpression of a constitutively active plasma membrane calcium pump with GFP identifies roles for intracellular calcium in controlling cell sorting during morphogenesis in Dictyostelium.
Developmental biology 1998;196(1):77-94.
1998: Z Han; Richard A Firtel
The homeobox-containing gene Wariai regulates anterior-posterior patterning and cell-type homeostasis in Dictyostelium.
Development (Cambridge, England) 1998;125(2):313-25.
1997: A Clark; A Nomura; S Mohanty; Richard A Firtel
A ubiquitin-conjugating enzyme is essential for developmental transitions in Dictyostelium.
Molecular biology of the cell 1997;8(10):1989-2002.
1997: Hui Ma; M Gamper; Carole A Parent; Richard A Firtel
The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase.
The EMBO journal 1997;16(14):4317-32.
1997: S K Mann; JM Brown; C Briscoe; Carole A Parent; G Pitt; Peter N Devreotes; Richard A Firtel
Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.
Developmental biology 1997;183(2):208-21.
1997: Susan Lee; R Escalante; Richard A Firtel
A Ras GAP is essential for cytokinesis and spatial patterning in Dictyostelium.
Development (Cambridge, England) 1997;124(5):983-96.
1997: Laurence Aubry; M Maeda; R Insall; Peter N Devreotes; Richard A Firtel
The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function.
The Journal of biological chemistry 1997;272(7):3883-6.
1996: Richard A Firtel
Interacting signaling pathways controlling multicellular development in Dictyostelium.
Current opinion in genetics & development 1996;6(5):545-54.
1996: M Gamper; P K Howard; Tony Hunter; Richard A Firtel
Multiple roles of the novel protein tyrosine phosphatase PTP3 during Dictyostelium growth and development.
Molecular and cellular biology 1996;16(5):2431-44.
1996: J A Hadwiger; K Natarajan; Richard A Firtel
Mutations in the Dictyostelium heterotrimeric G protein alpha subunit G alpha5 alter the kinetics of tip morphogenesis.
Development (Cambridge, England) 1996;122(4):1215-24.
1996: M Maeda; Laurence Aubry; R Insall; C Gaskins; Peter N Devreotes; Richard A Firtel
Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins.
The Journal of biological chemistry 1996;271(7):3351-4.
1996: C Gaskins; A M Clark; Laurence Aubry; Jeffrey E Segall; Richard A Firtel
The Dictyostelium MAP kinase ERK2 regulates multiple, independent developmental pathways.
Genes & development 1996;10(1):118-28.
1995: K Zhou; K Takegawa; Scott D Emr; Richard A Firtel
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development.
Molecular and cellular biology 1995;15(10):5645-56.
1995: Richard A Firtel
Integration of signaling information in controlling cell-fate decisions in Dictyostelium.
Genes & development 1995;9(12):1427-44.
1995: Gavin R Schnitzler; C Briscoe; JM Brown; Richard A Firtel
Serpentine cAMP receptors may act through a G protein-independent pathway to induce postaggregative development in Dictyostelium.
Cell 1995;81(5):737-45.
1995: J G Cao; Richard A Firtel
Growth and developmental functions of a human immunodeficiency virus Tat-binding protein/26S protease subunit homolog from Dictyostelium discoideum.
Molecular and cellular biology 1995;15(3):1725-36.
1995: C Briscoe; Richard A Firtel
Intercellular signaling. A kinase for cell-fate determination?
Current biology : CB 1995;5(3):228-31.
1995: Jeffrey E Segall; Adam Kuspa; Gad Shaulsky; M Ecke; M Maeda; C Gaskins; Richard A Firtel; William F Loomis
A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.
The Journal of cell biology 1995;128(3):405-13.
1994: S Dharmawardhane; A B Cubitt; A M Clark; Richard A Firtel
Regulatory role of the G alpha 1 subunit in controlling cellular morphogenesis in Dictyostelium.
Development (Cambridge, England) 1994;120(12):3549-61.
1994: R Hori; Richard A Firtel
Identification and characterization of multiple A/T-rich cis-acting elements that control expression from Dictyostelium actin promoters: the Dictyostelium actin upstream activating sequence confers growth phase expression and has enhancer-like properties.
Nucleic acids research 1994;22(23):5099-111.
1994: J A Hadwiger; Susan Lee; Richard A Firtel
The G alpha subunit G alpha 4 couples to pterin receptors and identifies a signaling pathway that is essential for multicellular development in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10566-70.
1994: S K Mann; D L Richardson; Susan Lee; Alan R Kimmel; Richard A Firtel
Expression of cAMP-dependent protein kinase in prespore cells is sufficient to induce spore cell differentiation in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10561-5.
1994: C Gaskins; M Maeda; Richard A Firtel
Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum.
Molecular and cellular biology 1994;14(10):6996-7012.
1994: J A Powell-Coffman; Gavin R Schnitzler; Richard A Firtel
A GBF-binding site and a novel AT element define the minimal sequences sufficient to direct prespore-specific expression in Dictyostelium discoideum.
Molecular and cellular biology 1994;14(9):5840-9.
1994: P K Howard; M Gamper; Tony Hunter; Richard A Firtel
Regulation by protein-tyrosine phosphatase PTP2 is distinct from that by PTP1 during Dictyostelium growth and development.
Molecular and cellular biology 1994;14(8):5154-64.
1994: J A Powell-Coffman; Richard A Firtel
Characterization of a novel Dictyostelium discoideum prespore-specific gene, PspB, reveals conserved regulatory sequences.
Development (Cambridge, England) 1994;120(6):1601-11.
1994: L Wu; C Gaskins; K Zhou; Richard A Firtel; Peter N Devreotes
Cloning and targeted mutations of G alpha 7 and G alpha 8, two developmentally regulated G protein alpha-subunit genes in Dictyostelium.
Molecular biology of the cell 1994;5(6):691-702.
1994: J L Dynes; A M Clark; Gad Shaulsky; Adam Kuspa; William F Loomis; Richard A Firtel
LagC is required for cell-cell interactions that are essential for cell-type differentiation in Dictyostelium.
Genes & development 1994;8(8):948-58.
1994: Gavin R Schnitzler; W H Fischer; Richard A Firtel
Cloning and characterization of the G-box binding factor, an essential component of the developmental switch between early and late development in Dictyostelium.
Genes & development 1994;8(4):502-14.
1994: F Carrel; S Dharmawardhane; A M Clark; J A Powell-Coffman; Richard A Firtel
Spatial and temporal expression of the Dictyostelium discoideum G alpha protein subunit G alpha 2: expression of a dominant negative protein inhibits proper prestalk to stalk differentiation.
Molecular biology of the cell 1994;5(1):7-16.
1993: S K Mann; Richard A Firtel
cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development.
Development (Cambridge, England) 1993;119(1):135-46.
1993: A B Cubitt; S Dharmawardhane; Richard A Firtel
Developmentally regulated changes in 1,2-diacylglycerol in Dictyostelium. Regulation by light and G proteins.
The Journal of biological chemistry 1993;268(23):17431-9.
1993: P K Howard; B M Sefton; Richard A Firtel
Tyrosine phosphorylation of actin in Dictyostelium associated with cell-shape changes.
Science (New York, N.Y.) 1993;259(5092):241-4.
1992: S K Mann; W M Yonemoto; Susan S Taylor; Richard A Firtel
DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10701-5.
1992: P K Howard; B M Sefton; Richard A Firtel
Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium.
Cell 1992;71(4):637-47.
1992: K Okaichi; A B Cubitt; G S Pitt; Richard A Firtel
Amino acid substitutions in the Dictyostelium G alpha subunit G alpha 2 produce dominant negative phenotypes and inhibit the activation of adenylyl cyclase, guanylyl cyclase, and phospholipase C.
Molecular biology of the cell 1992;3(7):735-47.
1992: J A Powell; J Galindo; Richard A Firtel
A negative transcriptional control region of a developmentally-regulated gene co-localizes with the origin of replication of an endogenous plasmid in Dictyostelium.
Nucleic acids research 1992;20(11):2795-802.
1992: A B Cubitt; Richard A Firtel
Characterization of phospholipase activity in Dictyostelium discoideum. Identification of a Ca(2+)-dependent polyphosphoinositide-specific phospholipase C.
The Biochemical journal 1992;283 ( Pt 2)():371-8.
1992: Robert Esch; P K Howard; Richard A Firtel
Regulation of the Dictyostelium cAMP-induced, prestalk-specific DdrasD gene: identification of cis-acting elements.
Nucleic acids research 1992;20(6):1325-32.
1992: J A Hadwiger; Richard A Firtel
Analysis of G alpha 4, a G-protein subunit required for multicellular development in Dictyostelium.
Genes & development 1992;6(1):38-49.
1992: A B Cubitt; F Carrel; S Dharmawardhane; C Gaskins; J Hadwiger; P Howard; S K Mann; K Okaichi; K Zhou; Richard A Firtel
Molecular genetic analysis of signal transduction pathways controlling multicellular development in Dictyostelium.
Cold Spring Harbor symposia on quantitative biology 1992;57():177-92.
1991: L Haberstroh; J Galindo; Richard A Firtel
Developmental and spatial regulation of a Dictyostelium prespore gene: cis-acting elements and a cAMP-induced, developmentally regulated DNA binding activity.
Development (Cambridge, England) 1991;113(3):947-58.
1991: Richard A Firtel
Signal transduction pathways controlling multicellular development in Dictyostelium.
Trends in genetics : TIG 1991;7(11-12):381-8.
1991: J A Hadwiger; Thomas Wilkie; M Strathmann; Richard A Firtel
Identification of Dictyostelium G alpha genes expressed during multicellular development.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(18):8213-7.
1991: S K Mann; Richard A Firtel
A developmentally regulated, putative serine/threonine protein kinase is essential for development in Dictyostelium.
Mechanisms of development 1991;35(2):89-101.
1991: Richard H Gomer; I S Yuen; Richard A Firtel
A secreted 80 x 10(3) Mr protein mediates sensing of cell density and the onset of development in Dictyostelium.
Development (Cambridge, England) 1991;112(1):269-78.
1991: Richard A Firtel
Putting the G in development.
Current biology : CB 1991;1(2):91-3.
1991: A Kumagai; J A Hadwiger; M Pupillo; Richard A Firtel
Molecular genetic analysis of two G alpha protein subunits in Dictyostelium.
The Journal of biological chemistry 1991;266(2):1220-8.
1991: Robert Esch; Richard A Firtel
cAMP and cell sorting control the spatial expression of a developmentally essential cell-type-specific ras gene in Dictyostelium.
Genes & development 1991;5(1):9-21.
1990: L Haberstroh; Richard A Firtel
A spatial gradient of expression of a cAMP-regulated prespore cell-type-specific gene in Dictyostelium.
Genes & development 1990;4(4):596-612.
1990: A L Hjorth; C Pears; J G Williams; Richard A Firtel
A developmentally regulated trans-acting factor recognizes dissimilar G/C-rich elements controlling a class of cAMP-inducible Dictyostelium genes.
Genes & development 1990;4(3):419-32.
1990: Richard A Firtel; A L Chapman
A role for cAMP-dependent protein kinase A in early Dictyostelium development.
Genes & development 1990;4(1):18-28.
1989: J L Dynes; Richard A Firtel
Molecular complementation of a genetic marker in Dictyostelium using a genomic DNA library.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7966-70.
1989: Richard A Firtel; peter van haastert; Alan R Kimmel; Peter N Devreotes
G protein linked signal transduction pathways in development: dictyostelium as an experimental system.
Cell 1989;58(2):235-9.
1989: M Pupillo; A Kumagai; G S Pitt; Richard A Firtel; Peter N Devreotes
Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4892-6.
1989: A L Hjorth; N C Khanna; Richard A Firtel
A trans-acting factor required for cAMP-induced gene expression in Dictyostelium is regulated developmentally and induced by cAMP.
Genes & development 1989;3(6):747-59.
1989: A Kumagai; M Pupillo; R Gundersen; R Miake-Lye; Peter N Devreotes; Richard A Firtel
Regulation and function of G alpha protein subunits in Dictyostelium.
Cell 1989;57(2):265-75.
1989: S K Mann; Richard A Firtel
Two-phase regulatory pathway controls cAMP receptor-mediated expression of early genes in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(6):1924-8.
1989: S Rubino; S K Mann; R T Hori; C Pinko; Richard A Firtel
Molecular analysis of a developmentally regulated gene required for Dictyostelium aggregation.
Developmental biology 1989;131(1):27-36.
1988: S K Mann; C Pinko; Richard A Firtel
Regulation of Dictyostelium early gene expression in cAMP bypass mutants.
Developmental biology 1988;130(1):406-10.
1988: S K Mann; C Pinko; Richard A Firtel
cAMP regulation of early gene expression in signal transduction mutants of Dictyostelium.
Developmental biology 1988;130(1):294-303.
1988: K G Ahern; P K Howard; Richard A Firtel
Identification of regions essential for extrachromosomal replication and maintenance of an endogenous plasmid in Dictyostelium.
Nucleic acids research 1988;16(14B):6825-37.
1988: P K Howard; K G Ahern; Richard A Firtel
Establishment of a transient expression system for Dictyostelium discoideum.
Nucleic acids research 1988;16(6):2613-23.
1988: S Datta; Richard A Firtel
An 80-bp cis-acting regulatory region controls cAMP and development regulation of a prestalk gene in Dictyostelium.
Genes & development 1988;2(3):294-304.
1988: A Kumagai; S K Mann; M Pupillo; G Pitt; Peter N Devreotes; Richard A Firtel
A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():675-85.
1988: M Pupillo; P Klein; R Vaughan; G Pitt; P Lilly; T Sun; Peter N Devreotes; A Kumagai; Richard A Firtel
cAMP receptor and G-protein interactions control development in Dictyostelium.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():657-65.
1988: A Hjorth; S Datta; N C Khanna; Richard A Firtel
Analysis of cis and trans elements involved in cAMP-inducible gene expression in Dictyostelium discoideum.
Developmental genetics 1988;9(4-5):435-54.
1988: S K Mann; C Pinko; Richard A Firtel
Control of early gene expression in Dictyostelium.
Developmental genetics 1988;9(4-5):337-50.
1986: Charles Saxe; Richard A Firtel
Regulation of late gene expression in a temperature-sensitive cohesion-defective mutant of Dictyostelium discoideum.
Developmental genetics 1986;7(2):99-108.