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Markus Fischer

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Arindam Talukdar; Yujie Zhao; Adelbert Bacher; Markus Fischer; Boris Illarionov; Wei Lv; Mark Cushman
O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase.
Ekaterina Morgunova; Boris Illarionov; Sabine Saller; Aleksander Popov; Thota Sambaiah; Adelbert Bacher; Mark Cushman; Markus Fischer; Rudolf Ladenstein
Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis.
Arindam Talukdar; Ekaterina Morgunova; Jianxin Duan; Winfried Meining; Nicolas Foloppe; Lennart Nilsson; Adelbert Bacher; Boris Illarionov; Markus Fischer; Rudolf Ladenstein; Mark Cushman
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase.

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All Publications

2012: Arindam Talukdar; Yujie Zhao; Adelbert Bacher; Markus Fischer; Boris Illarionov; Wei Lv; Mark Cushman
O-Nucleoside, S-nucleoside, and N-nucleoside probes of lumazine synthase and riboflavin synthase.
The Journal of organic chemistry 2012;77(14):6239-61.
2010: Ekaterina Morgunova; Boris Illarionov; Sabine Saller; Aleksander Popov; Thota Sambaiah; Adelbert Bacher; Mark Cushman; Markus Fischer; Rudolf Ladenstein
Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 9):1001-11.
2010: Arindam Talukdar; Ekaterina Morgunova; Jianxin Duan; Winfried Meining; Nicolas Foloppe; Lennart Nilsson; Adelbert Bacher; Boris Illarionov; Markus Fischer; Rudolf Ladenstein; Mark Cushman
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase.
Bioorganic & medicinal chemistry 2010;18(10):3518-34.
2009: Arindam Talukdar; Meghan Breen; Adelbert Bacher; Boris Illarionov; Markus Fischer; Gunda I Georg; Qi-Zhuang Ye; Mark Cushman
Discovery and development of a small molecule library with lumazine synthase inhibitory activity.
The Journal of organic chemistry 2009;74(15):5123-34.
2009: Yujie Zhao; Adelbert Bacher; Boris Illarionov; Markus Fischer; Gunda I Georg; Qi-Zhuang Ye; Phillip E Fanwick; Scott Franzblau; Baojie Wan; Mark Cushman
Discovery and development of the covalent hydrates of trifluoromethylated pyrazoles as riboflavin synthase inhibitors with antibiotic activity against Mycobacterium tuberculosis.
The Journal of organic chemistry 2009;74(15):5297-303.
2009: Wolfgang Eisenreich; Markus Fischer; Werner Römisch-Margl; Monika Joshi; Gerald Richter; Adelbert Bacher; Stefan Weber
Tryptophan 13C nuclear-spin polarization generated by intraprotein electron transfer in a LOV2 domain of the blue-light receptor phototropin.
Biochemical Society transactions 2009;37(Pt 2):382-6.
2008: Tsyr-Yan Yu; Robert D O'Connor; Astrid Sivertsen; Colby Chiauzzi; Barbara Poliks; Markus Fischer; Adelbert Bacher; Ilka Haase; Mark Cushman; Jacob Schaefer
(15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase.
Biochemistry 2008;47(52):13942-51.
2008: Wolfgang Eisenreich; Monika Joshi; Stefan Weber; Adelbert Bacher; Markus Fischer
Natural abundance solution 13C NMR studies of a phototropin with photoinduced polarization.
Journal of the American Chemical Society 2008;130(41):13544-5.
2008: Lorenz Chatwell; Victoria Illarionova; Boris Illarionov; Wolfgang Eisenreich; Robert Huber; Arne Skerra; Adelbert Bacher; Markus Fischer
Structure of lumazine protein, an optical transponder of luminescent bacteria.
Journal of molecular biology 2008;382(1):44-55.
2008: Werner Römisch-Margl; Wolfgang Eisenreich; Ilka Haase; Adelbert Bacher; Markus Fischer
2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthases of fungi and archaea.
The FEBS journal 2008;275(17):4403-14.
2008: Lidia Rodríguez-Fernández; F Javier López-Jaramillo; Adelbert Bacher; Markus Fischer; Sevil Weinkauf
Improvement of the quality of lumazine synthase crystals by protein engineering.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 7):625-8.
2008: Yanlei Zhang; Boris Illarionov; Ekaterina Morgunova; Guangyi Jin; Adelbert Bacher; Markus Fischer; Rudolf Ladenstein; Mark Cushman
A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications.
The Journal of organic chemistry 2008;73(7):2715-24.
2007: Boris Illarionov; Wolfgang Eisenreich; Martina Wirth; Chan Yong Lee; Young Eun Woo; Adelbert Bacher; Markus Fischer
Lumazine proteins from photobacteria: localization of the single ligand binding site to the N-terminal domain.
Biological chemistry 2007;388(12):1313-23.
2007: Wolfgang Eisenreich; Monika Joshi; Boris Illarionov; Gerald Richter; Werner Römisch-Margl; Franz Müller; Adelbert Bacher; Markus Fischer
13C Isotopologue editing of FMN bound to phototropin domains.
The FEBS journal 2007;274(22):5876-90.
2007: Yanlei Zhang; Guangyi Jin; Boris Illarionov; Adelbert Bacher; Markus Fischer; Mark Cushman
A new series of 3-alkyl phosphate derivatives of 4,5,6,7-tetrahydro-1-D-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as inhibitors of lumazine synthase: design, synthesis, and evaluation.
The Journal of organic chemistry 2007;72(19):7176-84.
2007: Arindam Talukdar; Boris Illarionov; Adelbert Bacher; Markus Fischer; Mark Cushman
Synthesis and enzyme inhibitory activity of the s-nucleoside analogue of the ribitylaminopyrimidine substrate of lumazine synthase and product of riboflavin synthase.
The Journal of organic chemistry 2007;72(19):7167-75.
2007: Ekaterina Morgunova; Sabine Saller; Ilka Haase; Mark Cushman; Adelbert Bacher; Markus Fischer; Rudolf Ladenstein
Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design.
The Journal of biological chemistry 2007;282(23):17231-41.
2007: Johannes Kaiser; Boris Illarionov; Felix Rohdich; Wolfgang Eisenreich; Sabine Saller; Jan Van den Brulle; Mark Cushman; Adelbert Bacher; Markus Fischer
A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway.
Analytical biochemistry 2007;365(1):52-61.
2007: Yanlei Zhang; Boris Illarionov; Adelbert Bacher; Markus Fischer; Gunda I Georg; Qi-Zhuang Ye; David VanderVelde; Phillip E Fanwick; Yunlong Song; Mark Cushman
A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative.
The Journal of organic chemistry 2007;72(8):2769-76.
2007: Chan Yong Lee; Boris Illarionov; Young-Eun Woo; Kristina Kemter; Ryu-Ryun Kim; Sabine Eberhardt; Mark Cushman; Wolfgang Eisenreich; Markus Fischer; Adelbert Bacher
Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli.
Journal of biochemistry and molecular biology 2007;40(2):239-46.
2006: Victoria Illarionova; Johannes Kaiser; Elena Ostrozhenkova; Adelbert Bacher; Markus Fischer; Wolfgang Eisenreich; Felix Rohdich
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods.
The Journal of organic chemistry 2006;71(23):8824-34.
2006: Ekaterina Morgunova; Boris Illarionov; Thota Sambaiah; Ilka Haase; Adelbert Bacher; Mark Cushman; Markus Fischer; Rudolf Ladenstein
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis.
The FEBS journal 2006;273(20):4790-804.
2006: Xiaofeng Zhang; Peter V Konarev; Maxim V Petoukhov; Dmitri I Svergun; Li Xing; R Holland Cheng; Ilka Haase; Markus Fischer; Adelbert Bacher; Rudolf Ladenstein; Winfried Meining
Multiple assembly states of lumazine synthase: a model relating catalytic function and molecular assembly.
Journal of molecular biology 2006;362(4):753-70.
2006: Lorenz Chatwell; Tobias Krojer; Alexander Fidler; Werner Römisch; Wolfgang Eisenreich; Adelbert Bacher; Robert Huber; Markus Fischer
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii.
Journal of molecular biology 2006;359(5):1334-51.
2006: Winfried Meining; Johannes Scheuring; Markus Fischer; Sevil Weinkauf
Cloning, purification, crystallization and preliminary crystallographic analysis of SecA from Enterococcus faecalis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 6):583-5.
2006: Markus Fischer; Ilka Haase; Sebastian Wiesner; Annette Müller-Taubenberger
Visualizing cytoskeleton dynamics in mammalian cells using a humanized variant of monomeric red fluorescent protein.
FEBS letters 2006;580(10):2495-502.
2006: Arne Ramsperger; Martin Augustin; Anne-Kathrin Schott; Stefan Gerhardt; Tobias Krojer; Wolfgang Eisenreich; Boris Illarionov; Mark Cushman; Adelbert Bacher; Robert Huber; Markus Fischer
Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: stereochemical implications.
The Journal of biological chemistry 2006;281(2):1224-32.
2005: Boris Illarionov; Chan Yong Lee; Adelbert Bacher; Markus Fischer; Wolfgang Eisenreich
Random isotopolog libraries for protein perturbation studies. 13C NMR studies on lumazine protein of Photobacterium leiognathi.
The Journal of organic chemistry 2005;70(24):9947-54.
2005: Mark Cushman; Guangyi Jin; Thota Sambaiah; Boris Illarionov; Markus Fischer; Rudolf Ladenstein; Adelbert Bacher
Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase.
The Journal of organic chemistry 2005;70(20):8162-70.
2005: Boris Illarionov; Wolfgang Eisenreich; Nicholas Schramek; Adelbert Bacher; Markus Fischer
Biosynthesis of vitamin B2: diastereomeric reaction intermediates of archaeal and non-archaeal riboflavin synthases.
The Journal of biological chemistry 2005;280(31):28541-6.
2005: Markus Fischer; Werner Römisch; Boris Illarionov; Wolfgang Eisenreich; Adelbert Bacher
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
Biochemical Society transactions 2005;33(Pt 4):780-4.
2005: Markus Fischer; Adelbert Bacher
Biosynthesis of flavocoenzymes.
Natural product reports 2005;22(3):324-50.
2005: Markus Fischer; Ilka Haase; Richard Feicht; Nicholas Schramek; Peter Köhler; Peter Schieberle; Adelbert Bacher
Evolution of vitamin B2 biosynthesis: riboflavin synthase of Arabidopsis thaliana and its inhibition by riboflavin.
Biological chemistry 2005;386(5):417-28.
2005: Olga Gliko; Nikolaus Neumaier; Weichun Pan; Ilka Haase; Markus Fischer; Adelbert Bacher; Sevil Weinkauf; Peter G Vekilov
A metastable prerequisite for the growth of lumazine synthase crystals.
Journal of the American Chemical Society 2005;127(10):3433-8.
2005: Ekaterina Morgunova; Winfried Meining; Boris Illarionov; Ilka Haase; Guangyi Jin; Adelbert Bacher; Mark Cushman; Markus Fischer; Rudolf Ladenstein
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors.
Biochemistry 2005;44(8):2746-58.
2005: Jinhua Chen; Boris Illarionov; Adelbert Bacher; Markus Fischer; Ilka Haase; Gunda I Georg; Qi-Zhuang Ye; Zeqiang Ma; Mark Cushman
A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors.
Analytical biochemistry 2005;338(1):124-30.
2005: Boris Illarionov; Ilka Haase; Markus Fischer; Adelbert Bacher; Nicholas Schramek
Pre-steady-state kinetic analysis of riboflavin synthase using a pentacyclic reaction intermediate as substrate.
Biological chemistry 2005;386(2):127-36.
2005: Michael Koch; Milko Velarde; Mark D Harrison; Steffi Echt; Markus Fischer; Albrecht Messerschmidt; Christopher Dennison
Crystal structures of oxidized and reduced stellacyanin from horseradish roots.
Journal of the American Chemical Society 2005;127(1):158-66.
2004: Markus Fischer; Ilka Haase; Evelyn Simmeth; Günther Gerisch; Annette Müller-Taubenberger
A brilliant monomeric red fluorescent protein to visualize cytoskeleton dynamics in Dictyostelium.
FEBS letters 2004;577(1-2):227-32.
2004: Jinhua Chen; Thota Sambaiah; Boris Illarionov; Markus Fischer; Adelbert Bacher; Mark Cushman
Design, synthesis, and evaluation of acyclic C-nucleoside and N-methylated derivatives of the ribitylaminopyrimidine substrate of lumazine synthase as potential enzyme inhibitors and mechanistic probes.
The Journal of organic chemistry 2004;69(21):6996-7003.
2004: Markus Fischer; Anne-Kathrin Schott; Werner Römisch; Arne Ramsperger; Martin Augustin; Alexander Fidler; Adelbert Bacher; Gerald Richter; Robert Huber; Wolfgang Eisenreich
Evolution of vitamin B2 biosynthesis. A novel class of riboflavin synthase in Archaea.
Journal of molecular biology 2004;343(1):267-78.
2004: Markus Fischer; Werner Römisch; Sabine Saller; Boris Illarionov; Gerald Richter; Felix Rohdich; Wolfgang Eisenreich; Adelbert Bacher
Evolution of vitamin B2 biosynthesis: structural and functional similarity between pyrimidine deaminases of eubacterial and plant origin.
The Journal of biological chemistry 2004;279(35):36299-308.
2004: Stefanie Echt; Stefanie Bauer; Stefan Steinbacher; Robert Huber; Adelbert Bacher; Markus Fischer
Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans.
Journal of molecular biology 2004;341(4):1085-96.
2004: Boris Illarionov; Markus Fischer; Chan Yong Lee; Adelbert Bacher; Wolfgang Eisenreich
Rapid preparation of isotopolog libraries by in vivo transformation of 1)C-glucose. Studies on 6,7-dimethyl-8-ribityllumazine, a biosynthetic precursor of vitamin B2.
The Journal of organic chemistry 2004;69(17):5588-94.
2004: Michael Koch; Constanze Breithaupt; StefanIlka GerhardtHaase; Stefan Weber; Mark Cushman; Robert Huber; Adelbert Bacher; Markus Fischer
Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase.
European journal of biochemistry / FEBS 2004;271(15):3208-14.
2004: Stefan Steinbacher; Susanne Schiffmann; Adelbert Bacher; Markus Fischer
Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 7):1338-40.
2004: Stefanie Bauer; Anne-Kathrin Schott; Victoria Illarionova; Adelbert Bacher; Robert Huber; Markus Fischer
Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class.
Journal of molecular biology 2004;339(4):967-79.
2004: Gerd Bader; Mariola Gomez-Ortiz; Christoph Haussmann; Adelbert Bacher; Robert Huber; Markus Fischer
Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1068-75.
2004: Mark Cushman; Thota Sambaiah; Guangyi Jin; Boris Illarionov; Markus Fischer; Adelbert Bacher
Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase.
The Journal of organic chemistry 2004;69(3):601-12.
2003: Markus Fischer; Anne-Kathrin Schott; Kristina Kemter; Richard Feicht; Gerald Richter; Boris Illarionov; Wolfgang Eisenreich; Stefan Gerhardt; Mark Cushman; Stefan Steinbacher; Robert Huber; Adelbert Bacher
Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments.
BMC biochemistry 2003;4():18.
2003: Boris Illarionov; Ilka Haase; Adelbert Bacher; Markus Fischer; Nicholas Schramek
Presteady state kinetic analysis of riboflavin synthase.
The Journal of biological chemistry 2003;278(48):47700-6.
2003: Stefan Steinbacher; Susanne Schiffmann; Gerald Richter; Robert Huber; Adelbert Bacher; Markus Fischer
Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism.
The Journal of biological chemistry 2003;278(43):42256-65.
2003: Ilka Haase; Markus Fischer; Adelbert Bacher; Nicholas Schramek
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
The Journal of biological chemistry 2003;278(39):37909-15.
2003: Stefan Gerhardt; Stefanie Echt; Marco Busch; Jörg Freigang; Guenter Auerbach; Gerd Bader; William F Martin; Adelbert Bacher; Robert Huber; Markus Fischer
Structure and properties of an engineered transketolase from maize.
Plant physiology 2003;132(4):1941-9.
2003: Xiaofeng Zhang; Winfried Meining; Mark Cushman; Ilka Haase; Markus Fischer; Adelbert Bacher; Rudolf Ladenstein
A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus.
Journal of molecular biology 2003;328(1):167-82.
2003: Nicholas Schramek; Ilka Haase; Markus Fischer; Adelbert Bacher
Biosynthesis of riboflavin. Single turnover kinetic analysis of 6,7-dimethyl-8-ribityllumazine synthase.
Journal of the American Chemical Society 2003;125(15):4460-6.
2003: Stefanie Bauer; Kristina Kemter; Adelbert Bacher; Robert Huber; Markus Fischer; Stefan Steinbacher
Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold.
Journal of molecular biology 2003;326(5):1463-73.
2003: Ilka Haase; Simone Mörtl; Peter Köhler; Adelbert Bacher; Markus Fischer
Biosynthesis of riboflavin in archaea. 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii.
European journal of biochemistry / FEBS 2003;270(5):1025-32.
2003: Markus Fischer; Ilka Haase; Klaus Kis; Winfried Meining; Rudolf Ladenstein; Mark Cushman; Nicholas Schramek; Robert Huber; Adelbert Bacher
Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase.
Journal of molecular biology 2003;326(3):783-93.
2003: Jorge Rebelo; Guenter Auerbach; Gerd Bader; Andreas Bracher; Herbert Nar; Cornelia Hösl; Nicholas Schramek; Johannes Kaiser; Adelbert Bacher; Robert Huber; Markus Fischer
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I.
Journal of molecular biology 2003;326(2):503-16.
2002: Markus Fischer; Werner Romisch; Susanne Schiffmann; Mark Kelly; Hartmut Oschkinat; Stefan Steinbacher; Robert Huber; Wolfgang Eisenreich; Gerald Richter; Adelbert Bacher
Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii.
The Journal of biological chemistry 2002;277(44):41410-6.
2002: Mark Cushman; Donglai Yang; Jeffrey T Mihalic; Jinhua Chen; Stefan Gerhardt; Robert Huber; Markus Fischer; Klaus Kis; Adelbert Bacher
Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase.
The Journal of organic chemistry 2002;67(20):6871-7.
2002: Stefan Gerhardt; Anne-Kathrin Schott; Norman Kairies; Mark Cushman; Boris Illarionov; Wolfgang Eisenreich; Adelbert Bacher; Robert Huber; Stefan Steinbacher; Markus Fischer
Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine.
Structure (London, England : 1993) 2002;10(10):1371-81.
2002: Mark Cushman; Donglai Yang; Stefan Gerhardt; Robert Huber; Markus Fischer; Klaus Kis; Adelbert Bacher
Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase.
The Journal of organic chemistry 2002;67(16):5807-16.
2002: Nathalie Braun; Winfried Meining; Ulrike Hars; Markus Fischer; Rudolf Ladenstein; Robert Huber; Adelbert Bacher; Sevil Weinkauf; Luis Bachmann
Formation of metal nanoclusters on specific surface sites of protein molecules.
Journal of molecular biology 2002;321(2):341-53.
2002: Victoria Illarionova; Wolfgang Eisenreich; Markus Fischer; Christoph Haussmann; Werner Romisch; Gerald Richter; Adelbert Bacher
Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase.
The Journal of biological chemistry 2002;277(32):28841-7.
2002: Stefan Gerhardt; Ilka Haase; Stefan Steinbacher; Jens Thomas Kaiser; Mark Cushman; Adelbert Bacher; Robert Huber; Markus Fischer
The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase.
Journal of molecular biology 2002;318(5):1317-29.
2002: Anil K Mehta; Daniel R Studelska; Markus Fischer; Andreas Giessauf; Kristina Kemter; Adelbert Bacher; Mark Cushman; Jacob Schaefer
Investigation of the binding of epimer A of the covalent hydrate of 6,7-bis(trifluoromethyl)-8-D-ribityllumazine to a recombinant F22W Bacillus subtilis lumazine synthase mutant by (15)N[(19)F] REDOR NMR.
The Journal of organic chemistry 2002;67(7):2087-92.
2002: Nicholas Schramek; Andreas Bracher; Markus Fischer; Guenter Auerbach; Herbert Nar; Robert Huber; Adelbert Bacher
Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate.
Journal of molecular biology 2002;316(3):829-37.
2002: Markus Fischer; Ilka Haase; Richard Feicht; Gerald Richter; Stefan Gerhardt; Jean-Pierre Changeux; Robert Huber; Adelbert Bacher
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
European journal of biochemistry / FEBS 2002;269(2):519-26.
2001: Gerd Bader; S Schiffmann; A Herrmann; Markus Fischer; M Gütlich; Guenter Auerbach; Ploom Tarmo; Adelbert Bacher; Robert Huber; T Lemm
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP.
Journal of molecular biology 2001;312(5):1051-7.
2001: Johannes Scheuring; K Kugelbrey; Sevil Weinkauf; M Cushman; Adelbert Bacher; Markus Fischer
19F NMR ligand perturbation studies on 6,7-bis(trifluoromethyl)-8-ribityllumazine-7-hydrates and the lumazine synthase complex of Bacillus subtilis. Site-directed mutagenesis changes the mechanism and the stereoselectivity of the catalyzed haloform-type reaction.
The Journal of organic chemistry 2001;66(11):3811-9.
2001: Markus Fischer; P J Corringer; K Schott; Adelbert Bacher; Jean-Pierre Changeux
A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3567-70.
2001: Xiaofeng Zhang; Winfried Meining; Markus Fischer; Adelbert Bacher; Rudolf Ladenstein
X-ray structure analysis and crystallographic refinement of lumazine synthase from the hyperthermophile Aquifex aeolicus at 1.6 A resolution: determinants of thermostability revealed from structural comparisons.
Journal of molecular biology 2001;306(5):1099-114.
2001: Adelbert Bacher; Sabine Eberhardt; Wolfgang Eisenreich; Markus Fischer; Stefan Herz; Boris Illarionov; Klaus Kis; Gerald Richter
Biosynthesis of riboflavin.
Vitamins and hormones 2001;61():1-49.
2000: Guenter Auerbach; A Herrmann; Andreas Bracher; Gerd Bader; M Gutlich; Markus Fischer; M Neukamm; Marta Garrido-Franco; J Richardson; Herbert Nar; Robert Huber; Adelbert Bacher
Zinc plays a key role in human and bacterial GTP cyclohydrolase I.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13567-72.
2000: Felix Rohdich; Juraithip Wungsintaweekul; H Luttgen; Markus Fischer; Wolfgang Eisenreich; Christoph A Schuhr; Monika Fellermeier; Nicholas Schramek; Meinhart H Zenk; Adelbert Bacher
Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8251-6.
2000: Winfried Meining; S Mörtl; Markus Fischer; Mark Cushman; Adelbert Bacher; Rudolf Ladenstein
The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 A resolution reveals the binding mode of a phosphonate intermediate analogue.
Journal of molecular biology 2000;299(1):181-97.
2000: Adelbert Bacher; Sabine Eberhardt; Markus Fischer; Klaus Kis; Gerald Richter
Biosynthesis of vitamin b2 (riboflavin).
Annual review of nutrition 2000;20():153-67.
1999: Andreas Bracher; Markus Fischer; Wolfgang Eisenreich; H Ritz; Nicholas Schramek; P Boyle; P Gentili; Robert Huber; Herbert Nar; Guenter Auerbach; Adelbert Bacher
Histidine 179 mutants of GTP cyclohydrolase I catalyze the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate.
The Journal of biological chemistry 1999;274(24):16727-35.
1998: Winfried Meining; Gudrun Tibbelin; Rudolf Ladenstein; Sabine Eberhardt; Markus Fischer; Adelbert Bacher
Evidence for local 32 symmetry in homotrimeric riboflavin synthase of Escherichia coli.
Journal of structural biology 1998;121(1):53-60.
1997: Guenter Auerbach; A Herrmann; M Gütlich; Markus Fischer; Uwe Jacob; Adelbert Bacher; Robert Huber
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters.
The EMBO journal 1997;16(24):7219-30.
1997: F Berglechner; Gerald Richter; Markus Fischer; Adelbert Bacher; RM Gschwind; M Huenges; Gerd Gemmecker; Horst Kessler
Studies on the NusB protein of Escherichia coli--expression and determination of secondary-structure elements by multinuclear NMR spectroscopy.
European journal of biochemistry / FEBS 1997;248(2):338-46.
1997: Gerald Richter; Markus Fischer; C Krieger; Sabine Eberhardt; Holger Lüttgen; I Gerstenschläger; Adelbert Bacher
Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis.
Journal of bacteriology 1997;179(6):2022-8.
1997: Adelbert Bacher; Sabine Eberhardt; Markus Fischer; S Mörtl; Klaus Kis; K Kugelbrey; Johannes Scheuring; K Schott
Biosynthesis of riboflavin: lumazine synthase and riboflavin synthase.
Methods in enzymology 1997;280():389-99.
1997: Adelbert Bacher; Gerald Richter; H Ritz; Sabine Eberhardt; Markus Fischer; C Krieger
Biosynthesis of riboflavin: GTP cyclohydrolase II, deaminase, and reductase.
Methods in enzymology 1997;280():382-9.
1996: S Mörtl; Markus Fischer; Gerald Richter; J Tack; S Weinkauf; Adelbert Bacher
Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli.
The Journal of biological chemistry 1996;271(52):33201-7.
1996: Johannes Scheuring; Markus Fischer; Mark Cushman; J Lee; Adelbert Bacher; H Oschkinat
NMR analysis of site-specific ligand binding in oligomeric proteins. Dynamic studies on the interaction of riboflavin synthase with trifluoromethyl-substituted intermediates.
Biochemistry 1996;35(30):9637-46.
1996: Adelbert Bacher; Markus Fischer; Klaus Kis; K Kugelbrey; S Mörtl; Johannes Scheuring; S Weinkauf; Sabine Eberhardt; K Schmidt-Bäse; Robert Huber; K Ritsert; Mark Cushman; Rudolf Ladenstein
Biosynthesis of riboflavin: structure and mechanism of lumazine synthase.
Biochemical Society transactions 1996;24(1):89-94.
1996: Herbert Nar; Robert Huber; Winfried Meining; Andreas Bracher; Markus Fischer; C Hösl; H Ritz; C Schmid; S Weinkauf; Adelbert Bacher
Structure and mechanism of GTP cyclohydrolase I of Escherichia coli.
Biochemical Society transactions 1996;24(1):37S.
1996: Markus Fischer; Sabine Eberhardt; Gerald Richter; Cornelia Krieger; I Gerstenschlåger; Adelbert Bacher
Biosynthesis of riboflavin. Bifunctional pyrimidine deaminase/reductase of Escherichia coli and Bacillus subtilis.
Biochemical Society transactions 1996;24(1):35S.
1995: Herbert Nar; Robert Huber; Guenter Auerbach; Markus Fischer; C Hösl; H Ritz; Andreas Bracher; Winfried Meining; Sabine Eberhardt; Adelbert Bacher
Active site topology and reaction mechanism of GTP cyclohydrolase I.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12120-5.