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Charles Fisher

Research Profile

Chemicals & Drugs

Concepts & Ideas

Living Beings

Disorders

Maple Syrup Urine Disease

Genes & Molecular Sequences

Amino Acid Sequences

Procedures

Phenomena

Hydroxylation

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Publications

TOP 3
Manjunath S Shet; Charles W Fisher; Yves Tremblay; Alain Belanger; Alan J Conley; J Ian Mason; Ronald W Estabrook
Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase.
Michel Kranendonk; Filipa Carreira Barbosa; P Theisen; António Laires; Charles W Fisher; Jose Rueff; Ronald W Estabrook; Nico P E Vermeulen
Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies.
Michel Kranendonk; Charles W Fisher; R Roda; Filipa Carreira Barbosa; P Theisen; António Laires; Jose Rueff; Nico P E Vermeulen; Ronald W Estabrook
Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems.

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All Publications

2007: Manjunath S Shet; Charles W Fisher; Yves Tremblay; Alain Belanger; Alan J Conley; J Ian Mason; Ronald W Estabrook
Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase.
Drug metabolism reviews 2007;39(2-3):289-307.
1999: Michel Kranendonk; Filipa Carreira Barbosa; P Theisen; António Laires; Charles W Fisher; Jose Rueff; Ronald W Estabrook; Nico P E Vermeulen
Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies.
Mutation research 1999;441(1):73-83.
1999: Michel Kranendonk; Charles W Fisher; R Roda; Filipa Carreira Barbosa; P Theisen; António Laires; Jose Rueff; Nico P E Vermeulen; Ronald W Estabrook
Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems.
Mutation research 1999;439(2):287-300.
1997: Manjunath S Shet; Michael J McPhaul; Charles W Fisher; Nancy R Stallings; Ronald W Estabrook
Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(11):1298-303.
1997: Manjunath S Shet; Charles W Fisher; Ronald W Estabrook
The function of recombinant cytochrome P450s in intact Escherichia coli cells: the 17 alpha-hydroxylation of progesterone and pregnenolone by P450c17.
Archives of biochemistry and biophysics 1997;339(1):218-25.
1996: Ronald W Estabrook; M S Shet; K Faulkner; Charles W Fisher
The use of electrochemistry for the synthesis of 17 alpha-hydroxyprogesterone by a fusion protein containing P450c17.
Endocrine research 1996;22(4):665-71.
1996: Ronald W Estabrook; M S Shet; Charles W Fisher; C M Jenkins; M R Waterman
The interaction of NADPH-P450 reductase with P450: an electrochemical study of the role of the flavin mononucleotide-binding domain.
Archives of biochemistry and biophysics 1996;333(1):308-15.
1996: M s Shet; Charles W Fisher; P L Holmans; Ronald W Estabrook
The omega-hydroxlyation of lauric acid: oxidation of 12-hydroxlauric acid to dodecanedioic acid by a purified recombinant fusion protein containing P450 4A1 and NADPH-P450 reductase.
Archives of biochemistry and biophysics 1996;330(1):199-208.
1996: Ronald W Estabrook; K M Faulkner; M S Shet; Charles W Fisher
Application of electrochemistry for P450-catalyzed reactions.
Methods in enzymology 1996;272():44-51.
1996: Charles W Fisher; M S Shet; Ronald W Estabrook
Construction of plasmids and expression in Escherichia coli of enzymatically active fusion proteins containing the heme-domain of a P450 linked to NADPH-P450 reductase.
Methods in enzymology 1996;272():15-25.
1995: K M Faulkner; M S Shet; Charles W Fisher; Ronald W Estabrook
Electrocatalytically driven omega-hydroxylation of fatty acids using cytochrome P450 4A1.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7705-9.
1995: M S Shet; K M Faulkner; P L Holmans; Charles W Fisher; Ronald W Estabrook
The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of 6 beta-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein.
Archives of biochemistry and biophysics 1995;318(2):314-21.
1994: P L Holmans; M S Shet; C A Martin-Wixtrom; Charles W Fisher; Ronald W Estabrook
The high-level expression in Escherichia coli of the membrane-bound form of human and rat cytochrome b5 and studies on their mechanism of function.
Archives of biochemistry and biophysics 1994;312(2):554-65.
1994: M S Shet; Charles W Fisher; M P Arlotto; C H Shackleton; P L Holmans; C A Martin-Wixtrom; Y Saeki; Ronald W Estabrook
Purification and enzymatic properties of a recombinant fusion protein expressed in Escherichia coli containing the domains of bovine P450 17A and rat NADPH-P450 reductase.
Archives of biochemistry and biophysics 1994;311(2):402-17.
1993: M S Shet; Charles W Fisher; P L Holmans; Ronald W Estabrook
Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11748-52.
1993: Charles W Fisher; C R Fisher; Jacinta L Chuang; Kim S Lau; David T Chuang; R P Cox
Occurrence of a 2-bp (AT) deletion allele and a nonsense (G-to-T) mutant allele at the E2 (DBT) locus of six patients with maple syrup urine disease: multiple-exon skipping as a secondary effect of the mutations.
American journal of human genetics 1993;52(2):414-24.
1992: Charles W Fisher; M S Shet; D L Caudle; C A Martin-Wixtrom; Ronald W Estabrook
High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10817-21.
1992: R Max Wynn; Jacinta L Chuang; J R Davie; Charles W Fisher; M A Hale; R P Cox; David T Chuang
Cloning and expression in Escherichia coli of mature E1 beta subunit of bovine mitochondrial branched-chain alpha-keto acid dehydrogenase complex. Mapping of the E1 beta-binding region on E2.
The Journal of biological chemistry 1992;267(3):1881-7.
1992: Charles W Fisher; D L Caudle; C Martin-Wixtrom; Linda C Quattrochi; R H Tukey; M R Waterman; Ronald W Estabrook
High-level expression of functional human cytochrome P450 1A2 in Escherichia coli.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):759-64.
1991: N Dariush; Charles W Fisher; R P Cox; David T Chuang
Structure of the gene encoding the entire mature E1 alpha subunit of human branched-chain alpha-keto acid dehydrogenase complex (1991) FEBS Letters 284, 34-38.
FEBS letters 1991;291(2):376-7.
1991: C R Fisher; Jacinta L Chuang; R P Cox; Charles W Fisher; robert star; David T Chuang
Maple syrup urine disease in Mennonites. Evidence that the Y393N mutation in E1 alpha impedes assembly of the E1 component of branched-chain alpha-keto acid dehydrogenase complex.
The Journal of clinical investigation 1991;88(3):1034-7.
1991: C R Fisher; Charles W Fisher; David T Chuang; R P Cox
Occurrence of a Tyr393----Asn (Y393N) mutation in the E1 alpha gene of the branched-chain alpha-keto acid dehydrogenase complex in maple syrup urine disease patients from a Mennonite population.
American journal of human genetics 1991;49(2):429-34.
1991: N Dariush; Charles W Fisher; R P Cox; David T Chuang
Structure of the gene encoding the entire mature E1 alpha subunit of human branched-chain alpha-keto acid dehydrogenase complex.
FEBS letters 1991;284(1):34-8.
1991: Kim S Lau; J Lee; Charles W Fisher; R P Cox; David T Chuang
Premature termination of transcription and alternative splicing in the human transacylase (E2) gene of the branched-chain alpha-ketoacid dehydrogenase complex.
FEBS letters 1991;279(2):229-32.
1991: David T Chuang; Charles W Fisher; Kim S Lau; T A Griffin; R Max Wynn; R P Cox
Maple syrup urine disease: domain structure, mutations and exon skipping in the dihydrolipoyl transacylase (E2) component of the branched-chain alpha-keto acid dehydrogenase complex.
Molecular biology & medicine 1991;8(1):49-63.
1991: Charles W Fisher; Kim S Lau; C R Fisher; R Max Wynn; R P Cox; David T Chuang
A 17-bp insertion and a Phe215----Cys missense mutation in the dihydrolipoyl transacylase (E2) mRNA from a thiamine-responsive maple syrup urine disease patient WG-34.
Biochemical and biophysical research communications 1991;174(2):804-9.
1991: Kim S Lau; R L Eddy; T B Shows; Charles W Fisher; David T Chuang; R P Cox
Localization of the dihydrolipoamide branched-chain transacylase gene (DBT) of the human branched-chain keto acid dehydrogenase complex to chromosome 1.
Cytogenetics and cell genetics 1991;56(1):33-5.
1989: Charles W Fisher; Jacinta L Chuang; T A Griffin; Kim S Lau; R P Cox; David T Chuang
Molecular phenotypes in cultured maple syrup urine disease cells. Complete E1 alpha cDNA sequence and mRNA and subunit contents of the human branched chain alpha-keto acid dehydrogenase complex.
The Journal of biological chemistry 1989;264(6):3448-53.
1988: C W Hu; Kim S Lau; T A Griffin; Jacinta L Chuang; Charles W Fisher; R P Cox; David T Chuang
Isolation and sequencing of a cDNA encoding the decarboxylase (E1)alpha precursor of bovine branched-chain alpha-keto acid dehydrogenase complex. Expression of E1 alpha mRNA and subunit in maple-syrup-urine-disease and 3T3-L1 cells.
The Journal of biological chemistry 1988;263(18):9007-14.
1988: N Dariush; Charles W Fisher; A W Steggles
The nucleotide sequence of rabbit liver cytochrome b5 mRNA.
Protein sequences & data analysis 1988;1(5):351-3.