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Alan Flake

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Merianos Demetri J; Tiblad Eleonor; Santore Matthew T; Todorow Carlyn A; Laje Pablo; Endo Masayuki; Zoltick Philip W; Flake Alan W
Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice.
Santore Matthew T; Roybal Jessica L; Flake Alan W
Prenatal stem cell transplantation and gene therapy.
Peranteau William H; Heaton Todd E; Gu Yu-Chen; Volk Susan W; Bauer Thomas R; Alcorn Keith; Tuschong Laura M; Johnson Mark P; Hickstein Dennis D; Flake Alan W
Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency model.

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All Publications

2009: Merianos Demetri J; Tiblad Eleonor; Santore Matthew T; Todorow Carlyn A; Laje Pablo; Endo Masayuki; Zoltick Philip W; Flake Alan W
Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice.
The Journal of clinical investigation 2009;119(9):2590-600.
2009: Santore Matthew T; Roybal Jessica L; Flake Alan W
Prenatal stem cell transplantation and gene therapy.
Clinics in perinatology 2009;36(2):451-71, xi.
2009: Peranteau William H; Heaton Todd E; Gu Yu-Chen; Volk Susan W; Bauer Thomas R; Alcorn Keith; Tuschong Laura M; Johnson Mark P; Hickstein Dennis D; Flake Alan W
Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adhesion deficiency model.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(3):293-305.
2009: Laje Pablo; Shang Dezhi; Cao Wenjing; Niiya Masami; Endo Masayuki; Radu Antoneta; DeRogatis Nicole; Scheiflinger Friedrich; Zoltick Philip W; Flake Alan W; Zheng X Long
Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy.
Blood 2009;113(10):2172-80.
2009: Danzer Enrico; Ernst Linda M; Rintoul Natalie E; Johnson Mark P; Adzick N Scott; Flake Alan W
In utero meconium passage in fetuses and newborns with myelomeningocele.
Journal of neurosurgery. Pediatrics 2009;3(2):141-6.
2009: Niiya Masami; Endo Masayuki; Shang Dezhi; Zoltick Philip W; Muvarak Nidal E; Cao Wenjing; Jin Sheng-Yu; Skipwith Christopher G; Motto David G; Flake Alan W; Zheng X Long
Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(1):34-41.
2009: Wilson R Douglas; Hedrick Holly; Flake Alan W; Johnson Mark P; Bebbington Michael W; Mann Stephanie; Rychik Jack; Liechty Kenneth; Adzick N Scott
Sacrococcygeal teratomas: prenatal surveillance, growth and pregnancy outcome.
Fetal diagnosis and therapy 2009;25(1):15-20.
2008: Danzer Enrico; Adzick N Scott; Rintoul Natalie E; Zarnow Deborah M; Schwartz Erin S; Melchionni Jeanne; Ernst Linda M; Flake Alan W; Sutton Leslie N; Johnson Mark P
Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings.
Journal of neurosurgery. Pediatrics 2008;2(6):406-13.
2008: Danzer Enrico; Davey Marcus G; Kreiger Portia A; Ruchelli Eduardo D; Johnson Mark P; Adzick N Scott; Flake Alan W; Hedrick Holly L
Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: a morphometric study of lung parenchyma and muscularization of pulmonary arterioles.
Journal of pediatric surgery 2008;43(10):1767-75.
2008: Behrens Edward M; Ning Yue; Muvarak Nidal; Zoltick Philip W; Flake Alan W; Gallucci Stefania
Apoptotic cell-mediated immunoregulation of dendritic cells does not require iC3b opsonization.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):3018-26.
2008: Gonzaga Sílvia; Henriques-Coelho Tiago; Davey Marcus; Zoltick Philip W; Leite-Moreira Adelino F; Correia-Pinto Jorge; Flake Alan W
Cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung.
American journal of respiratory cell and molecular biology 2008;39(3):346-55.
2008: Ibele Anna; Flake Alan; Shaaban Aimen
Survival of a profoundly hydropic fetus with a sacrococcygeal teratoma delivered at 27 weeks of gestation for maternal mirror syndrome.
Journal of pediatric surgery 2008;43(8):e17-20.
2008: Merianos Demetri; Heaton Todd; Flake Alan W
In utero hematopoietic stem cell transplantation: progress toward clinical application.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(7):729-40.
2008: Laje Pablo; Peranteau William H; Flake Alan W
Repair of indirect inguinal hernias by "laparoscopic joining of the edges".
Surgical laparoscopy, endoscopy & percutaneous techniques 2008;18(3):280-2.
2008: Tran Kha M; Flake Alan W; Kalawadia Nina V; Maxwell Lynne G; Rehman Mohamed A
Emergent excision of a prenatally diagnosed sacrococcygeal teratoma.
Paediatric anaesthesia 2008;18(5):431-4.
2008: Badillo Andrea T; Hedrick Holly L; Wilson R Douglas; Danzer Enrico; Bebbington Michael W; Johnson Mark P; Liechty Kenneth W; Flake Alan W; Adzick N Scott
Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes.
Journal of pediatric surgery 2008;43(4):647-53.
2008: Biard Jean-Marc; Schwarz Uwe; Davey Marcus G; Danzer Enrico; Johnson Mark P; Flake Alan W; Adzick Scott N; Hedrick Holly L
Main bronchus occlusion for treatment of congenital diaphragmatic hernia in fetal lambs.
Journal of pediatric surgery 2008;43(4):620-6.
2008: Badillo Andrea T; Peranteau William H; Heaton Todd E; Quinn Courtney; Flake Alan W
Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease.
British journal of haematology 2008;141(2):224-34.
2008: Tsai Anthony Y; Liechty Kenneth W; Hedrick Holly L; Bebbington Michael; Wilson R Douglas; Johnson Mark P; Howell Lori J; Flake Alan W; Adzick N Scott
Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesions.
Journal of pediatric surgery 2008;43(3):513-7.
2008: Tiblad Eleonor; Wilson R Douglas; Carr Michael; Flake Alan W; Hedrick Holly; Johnson Mark P; Bebbington Michael W; Mann Stephanie; Adzick N Scott
OEIS sequence--a rare congenital anomaly with prenatal evaluation and postnatal outcome in six cases.
Prenatal diagnosis 2008;28(2):141-7.
2008: Liechty Kenneth W; Flake Alan W
Pulmonary vascular malformations.
Seminars in pediatric surgery 2008;17(1):9-16.
2008: Danzer Enrico; Radu Antoneta; Robinson Lauren E; Volpe MaryAnn V; Adzick N Scott; Flake Alan W
Morphologic analysis of the neuromuscular development of the anorectal unit in fetal rats with retinoic acid induced myelomeningocele.
Neuroscience letters 2008;430(2):157-62.
2008: Endo Masayuki; Zoltick Philip W; Peranteau William H; Radu Antoneta; Muvarak Nidal; Ito Mayumi; Yang Zaixin; Cotsarelis George; Flake Alan W
Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):131-7.
2008: Peranteau William H; Merchant Aziz M; Hedrick Holly L; Liechty Kenneth W; Howell Lori J; Flake Alan W; Wilson R Douglas; Johnson Mark P; Bebbington Michael W; Adzick N Scott
Prenatal course and postnatal management of peripheral bronchial atresia: association with congenital cystic adenomatoid malformation of the lung.
Fetal diagnosis and therapy 2008;24(3):190-6.
2007: Hedrick Holly L; Danzer Enrico; Merchant Aziz; Bebbington Michael W; Zhao Huaqing; Flake Alan W; Johnson Mark P; Liechty Kenneth W; Howell Lori J; Wilson R Douglas; Adzick N Scott
Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic hernia.
American journal of obstetrics and gynecology 2007;197(4):422.e1-4.
2007: Davey Marcus; Shegu Shincy; Danzer Enrico; Ruchelli Eduardo; Adzick Scott; Flake Alan; Hedrick Holly L
Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/glucocorticoid therapy.
American journal of obstetrics and gynecology 2007;197(4):381.e1-7.
2007: Sabatino Denise E; Mackenzie Tippi C; Peranteau William; Edmonson Shyrie; Campagnoli Cesare; Liu Yi-Lin; Flake Alan W; High Katherine A
Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(9):1677-85.
2007: Javazon Elisabeth H; Keswani Sundeep G; Badillo Andrea T; Crombleholme Timothy M; Zoltick Philip W; Radu Antoneta P; Kozin Elliot D; Beggs Kirstin; Malik Asim A; Flake Alan W
Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007;15(3):350-9.
2007: Badillo Andrea T; Beggs Kirstin J; Javazon Elisabeth H; Tebbets Jessica C; Flake Alan W
Murine bone marrow stromal progenitor cells elicit an in vivo cellular and humoral alloimmune response.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(4):412-22.
2007: Endo Masayuki; Zoltick Philip W; Chung Daniel C; Bennett Jean; Radu Antoneta; Muvarak Nidal; Flake Alan W
Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(3):579-87.
2007: Henriques-Coelho Tiago; Gonzaga Sílvia; Endo Masayuki; Zoltick Philip W; Davey Marcus; Leite-Moreira Adelino F; Correia-Pinto Jorge; Flake Alan W
Targeted gene transfer to fetal rat lung interstitium by ultrasound-guided intrapulmonary injection.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(2):340-7.
2007: Peranteau William H; Endo Masayuki; Adibe Obinna O; Flake Alan W
Evidence for an immune barrier after in utero hematopoietic-cell transplantation.
Blood 2007;109(3):1331-3.
2007: Danzer Enrico; Kiddoo Darcie A; Redden Robert A; Robinson Lauren; Radu Antoneta; Zderic Steve A; Doolin Edward J; Adzick N Scott; Flake Alan W
Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningocele.
American journal of physiology. Renal physiology 2007;292(1):F197-206.
2007: Merchant Aziz M; Peranteau William; Wilson R Douglas; Johnson Mark P; Bebbington Michael W; Hedrick Holly L; Flake Alan W; Adzick N Scott
Postnatal chest wall deformities after fetal thoracoamniotic shunting for congenital cystic adenomatoid malformation.
Fetal diagnosis and therapy 2007;22(6):435-9.
2007: Peranteau William H; Wilson R Douglas; Liechty Kenneth W; Johnson Mark P; Bebbington Michael W; Hedrick Holly L; Flake Alan W; Adzick N Scott
Effect of maternal betamethasone administration on prenatal congenital cystic adenomatoid malformation growth and fetal survival.
Fetal diagnosis and therapy 2007;22(5):365-71.
2007: Netta Denise A; Wilson R Douglas; Visintainer Paul; Johnson Mark P; Hedrick Holly L; Flake Alan W; Adzick N Scott
Gastroschisis: growth patterns and a proposed prenatal surveillance protocol.
Fetal diagnosis and therapy 2007;22(5):352-7.
2007: Wilson R Douglas; Johnson Mark P; Bebbington Michael; Flake Alan W; Hedrick Holly L; Sutton Leslie N; Adzick N Scott
Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta?
Fetal diagnosis and therapy 2007;22(5):348-51.
2006: Davey Marcus G; Danzer Enrico; Schwarz Uwe; Robinson Lauren; Shegu Shincy; Adzick N Scott; Flake Alan W; Hedrick Holly L
Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion.
Pediatric pulmonology 2006;41(12):1188-96.
2006: Peranteau William H; Endo Masayuki; Adibe Obinna O; Merchant Aziz; Zoltick Philip W; Flake Alan W
CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation.
Blood 2006;108(13):4268-74.
2006: Wilson R Douglas; Pawel Bruce; Bebbington Michael; Johnson Mark P; Lim Foong-Yen; Stamilio David; Silber Angela; Zakii Elaine; Flake Alan W
Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion.
Prenatal diagnosis 2006;26(11):1058-61.
2006: Adibe Obinna O; Nichol Peter F; Flake Alan W; Mattei Peter
Comparison of outcomes after laparoscopic and open pyloromyotomy at a high-volume pediatric teaching hospital.
Journal of pediatric surgery 2006;41(10):1676-8.
2006: Danzer Enrico; Hubbard Anne M; Hedrick Holly L; Johnson Mark P; Wilson R Douglas; Howell Lori J; Flake Alan W; Adzick N Scott
Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal MRI.
AJR. American journal of roentgenology 2006;187(4):W350-6.
2006: Shaaban Aimen F; Kim Heung Bae; Gaur Lasya; Liechty Kenneth W; Flake Alan W
Prenatal transplantation of cytokine-stimulated marrow improves early chimerism in a resistant strain combination but results in poor long-term engraftment.
Experimental hematology 2006;34(9):1278-87.
2006: Davey Marcus G; Danzer Enrico; Schwarz Uwe; Adzick N Scott; Flake Alan W; Hedrick Holly L
Prenatal glucocorticoids and exogenous surfactant therapy improve respiratory function in lambs with severe diaphragmatic hernia following fetal tracheal occlusion.
Pediatric research 2006;60(2):131-5.
2006: Haber Barbara A; Erlichman Jessi; Thayu Meena; Flake Alan W; Rand Elizabeth B
Successful revision of portoenterostomy in an infant with biliary atresia.
Journal of pediatric surgery 2006;41(7):e1-3.
2006: Flake Alan W
Necrotizing enterocolitis in preterm infants--is laparotomy necessary?
The New England journal of medicine 2006;354(21):2275-6.
2006: Danzer Enrico; Robinson Lauren E; Davey Marcus G; Schwarz Uwe; Volpe MaryAnn; Adzick N Scott; Flake Alan W; Hedrick Holly L
Tracheal occlusion in fetal rats alters expression of mesenchymal nuclear transcription factors without affecting surfactant protein expression.
Journal of pediatric surgery 2006;41(4):774-80.
2006: Ashizuka Shuichi; Peranteau William H; Hayashi Satoshi; Flake Alan W
Busulfan-conditioned bone marrow transplantation results in high-level allogeneic chimerism in mice made tolerant by in utero hematopoietic cell transplantation.
Experimental hematology 2006;34(3):359-68.
2006: Liechty Kenneth W; Hedrick Holly L; Hubbard Ann M; Johnson Mark P; Wilson R Douglas; Ruchelli Eduardo D; Howell Lori J; Crombleholme Timothy M; Flake Alan W; Adzick N Scott
Severe pulmonary hypoplasia associated with giant cervical teratomas.
Journal of pediatric surgery 2006;41(1):230-3.
2006: Wilson R Douglas; Hedrick Holly L; Liechty Kenneth W; Flake Alan W; Johnson Mark P; Bebbington Michael; Adzick N Scott
Cystic adenomatoid malformation of the lung: review of genetics, prenatal diagnosis, and in utero treatment.
American journal of medical genetics. Part A 2006;140(2):151-5.
2006: Badillo Andrea T; Flake Alan W
The regulatory role of stromal microenvironments in fetal hematopoietic ontogeny.
Stem cell reviews 2006;2(3):241-6.
2005: Fogel Mark A; Wilson R Douglas; Flake Alan; Johnson Mark; Cohen David; McNeal Gary; Tian Zhi-Yun; Rychik Jack
Preliminary investigations into a new method of functional assessment of the fetal heart using a novel application of 'real-time' cardiac magnetic resonance imaging.
Fetal diagnosis and therapy 2005;20(5):475-80.
2005: Danzer E; Schwarz U; Wehrli S; Radu A; Adzick N S; Flake A W
Retinoic acid induced myelomeningocele in fetal rats: characterization by histopathological analysis and magnetic resonance imaging.
Experimental neurology 2005;194(2):467-75.
2005: Keswani Sundeep G; Crombleholme Timothy M; Rychik Jack; Tian Zhiyun; Mackenzie Tippi C; Johnson Mark P; Wilson R Douglas; Flake Alan W; Hedrick Holly L; Howell Lori J; Adzick N Scott
Impact of continuous intraoperative monitoring on outcomes in open fetal surgery.
Fetal diagnosis and therapy 2005;20(4):316-20.
2005: Hedrick Holly L; Flake Alan W; Crombleholme Timothy M; Howell Lori J; Johnson Mark P; Wilson R Douglas; Adzick N Scott
The ex utero intrapartum therapy procedure for high-risk fetal lung lesions.
Journal of pediatric surgery 2005;40(6):1038-43; discussion 1044.
2005: Baptista Maria J; Melo-Rocha Gustavo; Pedrosa Carla; Gonzaga Sílvia; Teles Antónia; Estevão-Costa José; Areias José C; Flake Alan W; Leite-Moreira Adelino F; Correia-Pinto Jorge
Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia.
Journal of pediatric surgery 2005;40(4):658-65.
2005: Davey Marcus G; Biard Jean-Marc; Robinson Lauren; Tsai Jackie; Schwarz Uwe; Danzer Enrico; Adzick N Scott; Flake Alan W; Hedrick Holly L
Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic hernia.
Pediatric pulmonology 2005;39(4):359-67.
2005: Merchant Aziz M; Hedrick Holly L; Johnson Mark P; Wilson R Douglas; Crombleholme Timothy M; Howell Lori J; Adzick N Scott; Flake Alan W
Management of fetal mediastinal teratoma.
Journal of pediatric surgery 2005;40(1):228-31.
2005: Keswani Sundeep G; Crombleholme Timothy M; Pawel Bruce R; Johnson Mark P; Flake Alan W; Hedrick Holly L; Howell Lori J; Wilson R Douglas; Davis George H; Adzick N Scott
Prenatal diagnosis and management of mainstem bronchial atresia.
Fetal diagnosis and therapy 2005;20(1):74-8.
2005: MacKenzie Tippi C; Kobinger Gary P; Louboutin Jean-Pierre; Radu Antoneta; Javazon Elizabeth H; Sena-Esteves Miguel; Wilson James M; Flake Alan W
Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors.
The journal of gene medicine 2005;7(1):50-8.
2005: Javazon Elisabeth H; Merchant Aziz M; Danzer Enrico; Flake Alan W
Reconstitution of hematopoiesis following intrauterine transplantation of stem cells.
Methods in molecular medicine 2005;105():81-94.
2004: Steffens Sabine; Tebbets Jessica; Kramm Christof M; Lindemann Dirk; Flake Alan; Sena-Esteves Miguel
Transduction of human glial and neuronal tumor cells with different lentivirus vector pseudotypes.
Journal of neuro-oncology 2004;70(3):281-8.
2004: Flake Alan W
In utero stem cell transplantation.
Best practice & research. Clinical obstetrics & gynaecology 2004;18(6):941-58.
2004: Sena-Esteves Miguel; Tebbets Jessica C; Steffens Sabine; Crombleholme Timothy; Flake Alan W
Optimized large-scale production of high titer lentivirus vector pseudotypes.
Journal of virological methods 2004;122(2):131-9.
2004: Merchant Aziz M; Flake Alan W
Surgeons and stem cells: a pragmatic perspective on shifting paradigms.
Surgery 2004;136(5):975-80.
2004: Danzer E; Johnson M P; Wilson R D; Flake A W; Hedrick H L; Sutton L N; Adzick N S
Fetal head biometry following in-utero repair of myelomeningocele.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2004;24(6):606-11.
2004: Wilson R Douglas; Johnson Mark P; Flake Alan W; Crombleholme Timothy M; Hedrick Holly L; Wilson Jordan; Adzick N Scott
Reproductive outcomes after pregnancy complicated by maternal-fetal surgery.
American journal of obstetrics and gynecology 2004;191(4):1430-6.
2004: Midrio P; Faussone-Pellegrini M S; Vannucchi M G; Flake A W
Gastroschisis in the rat model is associated with a delayed maturation of intestinal pacemaker cells and smooth muscle cells.
Journal of pediatric surgery 2004;39(10):1541-7.
2004: Krag Thomas O B; Bogdanovich Sasha; Jensen Claus J; Fischer M Dominik; Hansen-Schwartz Jacob; Javazon Elisabeth H; Flake Alan W; Edvinsson Lars; Khurana Tejvir S
Heregulin ameliorates the dystrophic phenotype in mdx mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13856-60.
2004: Tang Xao X; Robinson Marjorie E; Riceberg Justin S; Kim David Y; Kung Bing; Titus Tracy B; Hayashi Satoshi; Flake Alan W; Carpentieri David; Ikegaki Naohiko
Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(17):5837-44.
2004: Rychik Jack; Tian Zhiyun; Cohen Meryl S; Ewing Stanford G; Cohen David; Howell Lori J; Wilson R Douglas; Johnson Mark P; Hedrick Holly L; Flake Alan W; Crombleholme Timothy M; Adzick N Scott
Acute cardiovascular effects of fetal surgery in the human.
Circulation 2004;110(12):1549-56.
2004: Wilson R Douglas; Baxter Jason K; Johnson Mark P; King Mary; Kasperski Stefanie; Crombleholme Timothy M; Flake Alan W; Hedrick Holly L; Howell Lori J; Adzick N Scott
Thoracoamniotic shunts: fetal treatment of pleural effusions and congenital cystic adenomatoid malformations.
Fetal diagnosis and therapy 2004;19(5):413-20.
2004: Biard Jean-Marc; Wilson R Douglas; Johnson Mark P; Hedrick Holly L; Schwarz Uwe; Flake Alan W; Crombleholme Timothy M; Adzick N Scott
Prenatally diagnosed giant omphaloceles: short- and long-term outcomes.
Prenatal diagnosis 2004;24(6):434-9.
2004: Krupnick Alexander S; Balsara Keki R; Kreisel Daniel; Riha Markus; Gelman Andrew E; Estives Miguel S; Amin Kunjlata M; Rosengard Bruce R; Flake Alan W
Fetal liver as a source of autologous progenitor cells for perinatal tissue engineering.
Tissue engineering 2004;10(5-6):723-35.
2004: Javazon Elisabeth H; Beggs Kirstin J; Flake Alan W
Mesenchymal stem cells: paradoxes of passaging.
Experimental hematology 2004;32(5):414-25.
2004: Hedrick Holly L; Flake Alan W; Crombleholme Timothy M; Howell Lori J; Johnson Mark P; Wilson R Douglas; Adzick N Scott
Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome.
Journal of pediatric surgery 2004;39(3):430-8; discussion 430-8.
2004: Hedrick Holly L; Crombleholme Timothy M; Flake Alan W; Nance Michael L; von Allmen Daniel; Howell Lori J; Johnson Mark P; Wilson R Douglas; Adzick N Scott
Right congenital diaphragmatic hernia: Prenatal assessment and outcome.
Journal of pediatric surgery 2004;39(3):319-23; discussion 319-23.
2004: Hayashi Satoshi; Hsieh Michael; Peranteau William H; Ashizuka Shuichi; Flake Alan W
Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and cotransplantation of LLME-treated, MHC-sensitized donor lymphocytes.
Experimental hematology 2004;32(3):290-9.
2004: Flake Alan W
The conceptual application of systems theory to stem cell biology: a matter of context.
Blood cells, molecules & diseases 2004;32(1):58-64.
2004: Olutoye Oluyinka O; Johnson Mark P; Coleman Beverly G; Crombleholme Timothy M; Adzick N Scott; Flake Alan W
Abnormal umbilical cord Doppler sonograms may predict impending demise in fetuses with sacrococcygeal teratoma. A report of two cases.
Fetal diagnosis and therapy 2004;19(1):35-9.
2004: Peranteau William H; Hayashi Satoshi; Kim Heung Bae; Shaaban Aimen F; Flake Alan W
In utero hematopoietic cell transplantation: what are the important questions?
Fetal diagnosis and therapy 2004;19(1):9-12.
2003: Bouchard Sarah; MacKenzie Tippi C; Radu Antoneta P; Hayashi Satoshi; Peranteau William H; Chirmule Narendra; Flake Alan W
Long-term transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adeno-associated viral vectors in mice.
The journal of gene medicine 2003;5(11):941-50.
2003: Olutoye Oluyinka O; Johnson Mark P; Coleman Beverly G; Crombleholme Timothy M; Adzick N Scott; Flake Alan W
Abnormal umbilical cord Dopplers may predict impending demise in fetuses with sacrococcygeal teratoma. A report of 2 cases.
Fetal diagnosis and therapy 2003;18(6):428-31.
2003: Correia-Pinto Jorge; Baptista Maria J; Pedrosa Carla; Estevão-Costa José; Flake Alan W; Leite-Moreira Adelino F
Fetal heart development in the nitrofen-induced CDH rat model: the role of mechanical and nonmechanical factors.
Journal of pediatric surgery 2003;38(10):1444-51.
2003: Evers B Mark; Weissman Irving L; Flake Alan W; Tabar Viviane; Weisel Richard D
Stem cells in clinical practice.
Journal of the American College of Surgeons 2003;197(3):458-78.
2003: Kitano Yoshihiro; von Allmen Daniel; Kanai Masaki; Adzick N Scott; Flake Alan W
Epinephrine inhibits tracheal occlusion induced lung growth in fetal sheep.
Fetal diagnosis and therapy 2003;18(5):333-7.
2003: Wilson R Douglas; Johnson Mark P; Crombleholme Timothy M; Flake Alan W; Hedrick Holly L; King Mary; Howell Lori J; Adzick N Scott
Chorioamniotic membrane separation following open fetal surgery: pregnancy outcome.
Fetal diagnosis and therapy 2003;18(5):314-20.
2003: Johnson Mark P; Sutton Leslie N; Rintoul Natalie; Crombleholme Timothy M; Flake Alan W; Howell Lori J; Hedrick Holly L; Wilson R Douglas; Adzick N Scott
Fetal myelomeningocele repair: short-term clinical outcomes.
American journal of obstetrics and gynecology 2003;189(2):482-7.
2003: Flake Alan W
Stem cell and genetic therapies for the fetus.
Seminars in pediatric surgery 2003;12(3):202-8.
2003: Lim Foong-Yen; Crombleholme Timothy M; Hedrick Holly L; Flake Alan W; Johnson Mark P; Howell Lori J; Adzick N Scott
Congenital high airway obstruction syndrome: natural history and management.
Journal of pediatric surgery 2003;38(6):940-5.
2003: Keswani Sundeep G; Johnson Mark P; Adzick N Scott; Hori Steven; Howell Lori J; Wilson R Douglas; Hedrick Holly; Flake Alan W; Crombleholme Timothy M
In utero limb salvage: fetoscopic release of amniotic bands for threatened limb amputation.
Journal of pediatric surgery 2003;38(6):848-51.
2003: Manno Catherine S; Chew Amy J; Hutchison Sylvia; Larson Peter J; Herzog Roland W; Arruda Valder R; Tai Shing Jen; Ragni Margaret V; Thompson Arthur; Ozelo Margareth; Couto Linda B; Leonard Debra G B; Johnson Frederick A; McClelland Alan; Scallan Ciaran; Skarsgard Erik; Flake Alan W; Kay Mark A; High Katherine A; Glader Bertil
AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B.
Blood 2003;101(8):2963-72.
2003: Vannucchi M G; Midrio P; Flake A W; Faussone-Pellegrini M S
Neuronal differentiation and myenteric plexus organization are delayed in gastroschisis: an immunohistochemical study in a rat model.
Neuroscience letters 2003;339(1):77-81.
2003: Hedrick Holly L; Flake Alan W; Crombleholme Timothy M; Howell Lori J; Johnson Mark P; Wilson R Douglas; Adzick N Scott
History of fetal diagnosis and therapy: Children's Hospital of Philadelphia experience.
Fetal diagnosis and therapy 2003;18(2):65-82.
2003: Davey Marcus G; Hedrick Holly L; Bouchard Sarah; Mendoza Julianne M; Schwarz Uwe; Adzick N Scott; Flake Alan W
Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postnatal lung function.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(3):1054-62.
2003: Hayashi Satoshi; Abdulmalik Osheiza; Peranteau William H; Ashizuka Shuichi; Campagnoli Cesare; Chen Qiukan; Horiuchi Kazumi; Asakura Toshio; Flake Alan W
Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy.
Experimental hematology 2003;31(2):176-84.
2003: Flake Alan W
Surgery in the human fetus: the future.
The Journal of physiology 2003;547(Pt 1):45-51.
2003: Adzick N Scott; Flake Alan W; Crombleholme Timothy M
Management of congenital lung lesions.
Seminars in pediatric surgery 2003;12(1):10-6.
2003: Davey M G; Hedrick H L; Bouchard S; Adzick N S; Flake A W; Doolin E J
Computer-assisted stereology: point fraction of lung parenchyma and alveolar surface density in fetal and newborn sheep.
Scanning 2003;25(1):37-44.
2002: Evans Mark I; Harrison Michael R; Flake Alan W; Johnson Mark P
Fetal therapy.
Best practice & research. Clinical obstetrics & gynaecology 2002;16(5):671-83.
2002: Davey M G; Hedrick H L; Mendoza J M; Kanai M; Adzick N S; Flake A W
Pulmonary epithelial liquid absorption, expressed in relation to alveolar surface area, is reduced in fetal lambs following in utero tracheal occlusion.
Pediatric pulmonology 2002;34(4):278-86.
2002: Flake Alan W
Genetic therapies for the fetus.
Clinical obstetrics and gynecology 2002;45(3):684-96; discussion 730-2.
2002: MacKenzie Tippi C; Kobinger Gary P; Kootstra Neeltje A; Radu Antoneta; Sena-Esteves Miguel; Bouchard Sarah; Wilson James M; Verma Inder M; Flake Alan W
Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(3):349-58.
2002: Peranteau William H; Hayashi Satoshi; Hsieh Michael; Shaaban Aimen F; Flake Alan W
High-level allogeneic chimerism achieved by prenatal tolerance induction and postnatal nonmyeloablative bone marrow transplantation.
Blood 2002;100(6):2225-34.
2002: MacKenzie Tippi C; Crombleholme Timothy M; Flake Alan W
The ex-utero intrapartum treatment.
Current opinion in pediatrics 2002;14(4):453-8.
2002: Hayashi Satoshi; Peranteau William H; Shaaban Aimen F; Flake Alan W
Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion.
Blood 2002;100(3):804-12.
2002: Cohen Meryl S; Rychik Jack; Bush David M; Tian Zhi-Yun; Howell Lori J; Adzick N Scott; Flake Alan W; Johnson Mark P; Spray Thomas L; Crombleholme Timothy M
Influence of congenital heart disease on survival in children with congenital diaphragmatic hernia.
The Journal of pediatrics 2002;141(1):25-30.
2002: Mackenzie Tippi C; Shaaban Aimen F; Radu Antoneta; Flake Alan W
Engraftment of bone marrow and fetal liver cells after in utero transplantation in MDX mice.
Journal of pediatric surgery 2002;37(7):1058-64.
2002: Correia-Pinto Jorge; Reis Joaquim L; Hutchins Grover M; Baptista Maria J; Estevão-Costa José; Flake Alan W; Leite-Moreira Adelino F
In utero meconium exposure increases spinal cord necrosis in a rat model of myelomeningocele.
Journal of pediatric surgery 2002;37(3):488-92.
2002: Bouchard Sarah; Johnson Mark P; Flake Alan W; Howell Lori J; Myers Laura B; Adzick N Scott; Crombleholme Timothy M
The EXIT procedure: experience and outcome in 31 cases.
Journal of pediatric surgery 2002;37(3):418-26.
2002: Crombleholme Timothy M; Coleman Beverly; Hedrick Holly; Liechty Kenneth; Howell Lori; Flake Alan W; Johnson Mark; Adzick N Scott
Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung.
Journal of pediatric surgery 2002;37(3):331-8.
2002: Mackenzie Tippi C; Crombleholme Timothy M; Johnson Mark P; Schnaufer Louise; Flake Alan W; Hedrick Holly L; Howell Lori J; Adzick N Scott
The natural history of prenatally diagnosed conjoined twins.
Journal of pediatric surgery 2002;37(3):303-9.
2002: Krupnick Alexander S; Shaaban Aimen; Radu Antoneta; Flake Alan W
Bone marrow tissue engineering.
Tissue engineering 2002;8(1):145-55.
2002: Krupnick Alexander S; Kreisel Daniel; Engels Friederike H; Szeto Wilson Y; Plappert Theodore; Popma Sicco H; Flake Alan W; Rosengard Bruce R
A novel small animal model of left ventricular tissue engineering.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2002;21(2):233-43.
2002: Correia-Pinto Jorge; Tavares Marta L; Baptista Maria J; Henriques-Coelho Tiago; Estevão-Costa José; Flake Alan W; Leite-Moreira Adelino F
Meconium dependence of bowel damage in gastroschisis.
Journal of pediatric surgery 2002;37(1):31-5.
2002: MacKenzie Tippi C; Flake Alan W
Human mesenchymal stem cells: insights from a surrogate in vivo assay system.
Cells, tissues, organs 2002;171(1):90-5.
2001: Flake A W
In utero transplantation of haemopoietic stem cells.
Best practice & research. Clinical haematology 2001;14(4):671-83.
2001: Hayashi S; Flake A W
In utero hematopoietic stem cell therapy.
Yonsei medical journal 2001;42(6):615-29.
2001: Arruda V R; Fields P A; Milner R; Wainwright L; De Miguel M P; Donovan P J; Herzog R W; Nichols T C; Biegel J A; Razavi M; Dake M; Huff D; Flake A W; Couto L; Kay M A; High K A
Lack of germline transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(6):586-92.
2001: Austin J C; Canning D A; Johnson M P; Flake A W; Carr M C
Vesicoamniotic shunt in a female fetus with the prune belly syndrome.
The Journal of urology 2001;166(6):2382.
2001: Flake A W
Prenatal intervention: ethical considerations for life-threatening and non-life-threatening anomalies.
Seminars in pediatric surgery 2001;10(4):212-21.
2001: Mackenzie T C; Howell L J; Flake A W; Adzick N S
The management of prenatally diagnosed choledochal cysts.
Journal of pediatric surgery 2001;36(8):1241-3.
2001: Kanai M; Kitano Y; von Allmen D; Davies P; Adzick N S; Flake A W
Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia: tracheal occlusion reverses the arterial structural abnormality.
Journal of pediatric surgery 2001;36(6):839-45.
2001: Mackenzie T C; Flake A W
Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep.
Blood cells, molecules & diseases 2001;27(3):601-4.
2001: Kitano Y; Kanai M; Davies P; von Allmen D; Yang E Y; Radu A; Kitano Y; Adzick N S; Flake A W
BAPS prize-1999: Lung growth induced by prenatal tracheal occlusion and its modifying factors: a study in the rat model of congenital diaphragmatic hernia.
Journal of pediatric surgery 2001;36(2):251-9.
2001: Kitano Y; Von Allmen D; Kanai M; Quinn T M; Davies P; Kitano Y; Flake A W
Fetal lung growth after short-term tracheal occlusion is linearly related to intratracheal pressure.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;90(2):493-500.
2001: Correia-Pinto J; Tavares M L; Baptista M J; Estevão-Costa J; Flake A W; Leite-Moreira A F
A new fetal rat model of gastroschisis: development and early characterization.
Journal of pediatric surgery 2001;36(1):213-6.
2001: Mackenzie T C; Flake A W
Multilineage differentiation of human MSC after in utero transplantation.
Cytotherapy 2001;3(5):403-5.
2000: Mahle W T; Rychik J; Tian Z Y; Cohen M S; Howell L J; Crombleholme T M; Flake A W; Adzick N S
Echocardiographic evaluation of the fetus with congenital cystic adenomatoid malformation.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2000;16(7):620-4.
2000: Kitano Y; Radu A; Shaaban A; Flake A W
Selection, enrichment, and culture expansion of murine mesenchymal progenitor cells by retroviral transduction of cycling adherent bone marrow cells.
Experimental hematology 2000;28(12):1460-9.
2000: Walsh D S; Hubbard A M; Olutoye O O; Howell L J; Crombleholme T M; Flake A W; Johnson M P; Adzick N S
Assessment of fetal lung volumes and liver herniation with magnetic resonance imaging in congenital diaphragmatic hernia.
American journal of obstetrics and gynecology 2000;183(5):1067-9.
2000: Flake A W; Crombleholme T M; Johnson M P; Howell L J; Adzick N S
Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: clinical experience with fifteen cases.
American journal of obstetrics and gynecology 2000;183(5):1059-66.
2000: Liechty K W; MacKenzie T C; Shaaban A F; Radu A; Moseley A M; Deans R; Marshak D R; Flake A W
Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep.
Nature medicine 2000;6(11):1282-6.
2000: Crombleholme T M; Sylvester K; Flake A W; Adzick N S
Salvage of a fetus with congenital high airway obstruction syndrome by ex utero intrapartum treatment (EXIT) procedure.
Fetal diagnosis and therapy 2000;15(5):280-2.
2000: Hoydu A K; Kitano Y; Kriss A; Hensley H; Bergey P; Flake A; Hubbard A; Leigh J S
In vivo, in utero microscopic magnetic resonance imaging: application in a rat model of diaphragmatic hernia.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;44(2):331-5.
2000: Pameijer C R; Hubbard A M; Coleman B; Flake A W
Combined pure esophageal atresia, duodenal atresia, biliary atresia, and pancreatic ductal atresia: prenatal diagnostic features and review of the literature.
Journal of pediatric surgery 2000;35(5):745-7.
2000: Kay M A; Manno C S; Ragni M V; Larson P J; Couto L B; McClelland A; Glader B; Chew A J; Tai S J; Herzog R W; Arruda V; Johnson F; Scallan C; Skarsgard E; Flake A W; High K A
Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.
Nature genetics 2000;24(3):257-61.
2000: Milner R; Kitano Y; Olutoye O; Flake A W; Adzick N S
Radiofrequency thermal ablation: a potential treatment for hydropic fetuses with a large chest mass.
Journal of pediatric surgery 2000;35(2):386-9.
2000: Kitano Y; Flake A W; Quinn T M; Kanai M; Davies P; Sablich T J; Schneider C; Adzick N S; von Allmen D
Lung growth induced by tracheal occlusion in the sheep is augmented by airway pressurization.
Journal of pediatric surgery 2000;35(2):216-21; discussion 221-2.
1999: Yang E Y; Flake A W; Adzick N S
Prospects for fetal gene therapy.
Seminars in perinatology 1999;23(6):524-34.
1999: Shaaban A F; Flake A W
Fetal hematopoietic stem cell transplantation.
Seminars in perinatology 1999;23(6):515-23.
1999: Kitano Y; Flake A W; Crombleholme T M; Johnson M P; Adzick N S
Open fetal surgery for life-threatening fetal malformations.
Seminars in perinatology 1999;23(6):448-61.
1999: Shaaban A F; Kim H B; Milner R; Flake A W
A kinetic model for the homing and migration of prenatally transplanted marrow.
Blood 1999;94(9):3251-7.
1999: Flake A W; Zanjani E D
In utero hematopoietic stem cell transplantation: ontogenic opportunities and biologic barriers.
Blood 1999;94(7):2179-91.
1999: Kitano Y; Davies P; von Allmen D; Adzick N S; Flake A W
Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(2):769-75.
1999: Liechty K W; Crombleholme T M; Weiner S; Bernick B; Flake A W; Adzick N S
The ex utero intrapartum treatment procedure for a large fetal neck mass in a twin gestation.
Obstetrics and gynecology 1999;93(5 Pt 2):824-5.
1999: Liechty K W; Crombleholme T M; Quinn T M; Cass D L; Flake A W; Adzick N S
Elevated platelet-derived growth factor-B in congenital cystic adenomatoid malformations requiring fetal resection.
Journal of pediatric surgery 1999;34(5):805-9; discussion 809-10.
1999: Yang E Y; Kim H B; Shaaban A F; Milner R; Adzick N S; Flake A W
Persistent postnatal transgene expression in both muscle and liver after fetal injection of recombinant adenovirus.
Journal of pediatric surgery 1999;34(5):766-72; discussion 772-3.
1999: Kim H B; Shaaban A F; Milner R; Fichter C; Flake A W
In utero bone marrow transplantation induces donor-specific tolerance by a combination of clonal deletion and clonal anergy.
Journal of pediatric surgery 1999;34(5):726-9; discussion 729-30.
1999: Quinn T M; Sylvester K G; Kitano Y; Kitano Y; Liechty K W; Jarrett B P; Adzick N S; Flake A W
TGF-beta2 is increased after fetal tracheal occlusion.
Journal of pediatric surgery 1999;34(5):701-4; discussion 704-5.
1999: Milner R; Shaaban A; Kim H B; Fichter C; Flake A W
Postnatal booster injections increase engraftment after in utero stem cell transplantation.
The Journal of surgical research 1999;83(1):44-7.
1999: Hubbard A M; Crombleholme T M; Adzick N S; Coleman B G; Howell L J; Meyer J S; Flake A W
Prenatal MRI evaluation of congenital diaphragmatic hernia.
American journal of perinatology 1999;16(8):407-13.
1998: Kitano Y; Yang E Y; von Allmen D; Quinn T M; Adzick N S; Flake A W
Tracheal occlusion in the fetal rat: a new experimental model for the study of accelerated lung growth.
Journal of pediatric surgery 1998;33(12):1741-4.
1998: Adzick N S; Harrison M R; Crombleholme T M; Flake A W; Howell L J
Fetal lung lesions: management and outcome.
American journal of obstetrics and gynecology 1998;179(4):884-9.
1998: Sylvester K G; Rasanen J; Kitano Y; Flake A W; Crombleholme T M; Adzick N S
Tracheal occlusion reverses the high impedance to flow in the fetal pulmonary circulation and normalizes its physiological response to oxygen at full term.
Journal of pediatric surgery 1998;33(7):1071-4; discussion 1074-5.
1998: Cass D L; Quinn T M; Yang E Y; Liechty K W; Crombleholme T M; Flake A W; Adzick N S
Increased cell proliferation and decreased apoptosis characterize congenital cystic adenomatoid malformation of the lung.
Journal of pediatric surgery 1998;33(7):1043-6; discussion 1047.
1998: Kim H B; Shaaban A F; Yang E Y; Liechty K W; Flake A W
Microchimerism and tolerance after in utero bone marrow transplantation in mice.
The Journal of surgical research 1998;77(1):1-5.
1998: Flake A W; Zanjani E D
In utero transplantation for thalassemia.
Annals of the New York Academy of Sciences 1998;850():300-11.
1997: Liechty K W; Crombleholme T M; Flake A W; Morgan M A; Kurth C D; Hubbard A M; Adzick N S
Intrapartum airway management for giant fetal neck masses: the EXIT (ex utero intrapartum treatment) procedure.
American journal of obstetrics and gynecology 1997;177(4):870-4.
1997: Flake A W; Zanjani E D
In utero hematopoietic stem cell transplantation. A status report.
JAMA : the journal of the American Medical Association 1997;278(11):932-7.

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