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Jean-Michel Flaman

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Yasmine Zerdoumi; Thierry Frebourg; Mariette Renaux-Petel; Richard Sesboüé; Juliette Aury-Landas; Catherine Bonaïti-Pellié; Gaëlle Bougeard; Céline Derambure; Jean-Michel Flaman
Drastic effect of germline TP53 missense mutations in Li-Fraumeni patients.
Anne Rovelet-Lecrux; Catherine Thomas-Antérion; Martine Vercelletto; David Wallon; Stéphanie Bombois; Dominique Campion; Bernard Croisile; Jean-Michel Flaman; Thierry Frébourg; Didier Hannequin; Isabelle Le Ber; Solenn Legallic; Richard Lévy; Olivier Martinaud; A Michon; Claire Paquet; Jérémie Pariente; Michèle Puel; Adeline Rollin-Sillaire
A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
Aude Duclos; André Blavier; Pascal Chambon; Françoise Charbonnier; Thierry Frébourg; Jean-Baptiste Latouche; Richard Redon; Jean-Michel Flaman
Pitfalls in the use of DGV for CNV interpretation.

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All Publications

2013: Yasmine Zerdoumi; Thierry Frebourg; Mariette Renaux-Petel; Richard Sesboüé; Juliette Aury-Landas; Catherine Bonaïti-Pellié; Gaëlle Bougeard; Céline Derambure; Jean-Michel Flaman
Drastic effect of germline TP53 missense mutations in Li-Fraumeni patients.
Human mutation 2013;34(3):453-61.
2012: Anne Rovelet-Lecrux; Catherine Thomas-Antérion; Martine Vercelletto; David Wallon; Stéphanie Bombois; Dominique Campion; Bernard Croisile; Jean-Michel Flaman; Thierry Frébourg; Didier Hannequin; Isabelle Le Ber; Solenn Legallic; Richard Lévy; Olivier Martinaud; A Michon; Claire Paquet; Jérémie Pariente; Michèle Puel; Adeline Rollin-Sillaire
A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
European journal of human genetics : EJHG 2012;20(6):613-7.
2011: Aude Duclos; André Blavier; Pascal Chambon; Françoise Charbonnier; Thierry Frébourg; Jean-Baptiste Latouche; Richard Redon; Jean-Michel Flaman
Pitfalls in the use of DGV for CNV interpretation.
American journal of medical genetics. Part A 2011;155A(10):2593-6.
2008: Elodie BOHERS; Nasrin Sarafan-Vasseur; Aurélie Drouet; Marianne Paresy; Jean-Baptiste Latouche; Jean-Michel Flaman; Richard Sesboüé; Thierry Frebourg
Gradual reduction of BUBR1 protein levels results in premature sister-chromatid separation then in aneuploidy.
Human genetics 2008;124(5):473-8.
2008: Damien Marsic; Jean-Michel Flaman; Joseph D Ng
New DNA polymerase from the hyperthermophilic marine archaeon Thermococcus thioreducens.
Extremophiles : life under extreme conditions 2008;12(6):775-88.
2008: J Couteau; Jean-Michel Flaman; Christophe Minier; Jérôme Cachot
Detection of environmental mutagens using the FACIM assay.
Marine environmental research 2008;66(1):62-3.
2007: Audrey Killian; Frédéric Di Fiore; Florence Le Pessot; France Blanchard; Aude Lamy; Gregory RAUX; Jean-Michel Flaman; Bernard Paillot; Pierre Michel; Jean-Christophe Sabourin; Jean-Jacques Tuech; Francis Michot; Jean-Pierre Kerckaert; Richard Sesboüé; Thierry Frebourg
A simple method for the routine detection of somatic quantitative genetic alterations in colorectal cancer.
Gastroenterology 2007;132(2):645-53.
2006: Audrey Killian; Nasrin Sarafan-Vasseur; Richard Sesboüé; Florence Le Pessot; France Blanchard; Aude Lamy; Michelle Laurent; Jean-Michel Flaman; Thierry Frébourg
Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis.
Genes, chromosomes & cancer 2006;45(9):874-81.
2004: Audrey Killian; Nathalie Le Meur; Richard Sesboüé; Jeannette Bourguignon; Gaëlle Bougeard; Julien Gautherot; Christian Bastard; Thierry Frébourg; Jean-Michel Flaman
Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability.
Oncogene 2004;23(53):8597-602.
2004: Jérôme Cachot; J Couteau; Thierry Frébourg; François Leboulenger; Jean-Michel Flaman
Functional analysis of chemically-induced mutations at the flounder TP53 locus, the FACIM assay.
Mutation research 2004;552(1-2):51-60.
2004: Jérôme Cachot; Jean-Michel Flaman; Thierry Frébourg; François Leboulenger
The European flounder (Platichthys flesus) TP53 functions as a temperature-sensitive transcription factor which inhibits cell growth in yeast.
Gene 2004;324():97-104.
2002: Nasrin Sarafan-Vasseur; Aude Lamy; Jeannette Bourguignon; Florence Le Pessot; Philip Hieter; Richard Sesboüé; Christian Bastard; Thierry Frébourg; Jean-Michel Flaman
Overexpression of B-type cyclins alters chromosomal segregation.
Oncogene 2002;21(13):2051-7.
2001: Gaëlle Bougeard; Jean-Marc Limacher; Cosette Martin; Frédéric Charbonnier; Audrey Killian; O Delattre; Michel Longy; Philippe Jonveaux; J P Fricker; Dominique Stoppa-Lyonnet; Jean-Michel Flaman; Thierry Frébourg
Detection of 11 germline inactivating TP53 mutations and absence of TP63 and HCHK2 mutations in 17 French families with Li-Fraumeni or Li-Fraumeni-like syndrome.
Journal of medical genetics 2001;38(4):253-7.
2001: Yoshito Kinoshita; AD Jarell; Jean-Michel Flaman; G Foltz; J Schuster; B L Sopher; Dwain K Irvin; K Kanning; H I Kornblum; P S Nelson; P Hieter; Richard S Morrison
Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells.
The Journal of biological chemistry 2001;276(9):6656-65.
2000: Valerie Robert; Pierre Michel; Jean-Michel Flaman; Anne Chiron; Cosette Martin; Frédéric Charbonnier; Bernard Paillot; Thierry Frebourg
High frequency in esophageal cancers of p53 alterations inactivating the regulation of genes involved in cell cycle and apoptosis.
Carcinogenesis 2000;21(4):563-5.
1999: Christian Pfister; Jean-Michel Flaman; Frédérick Dunet; Philippe Grise; Thierry Frebourg
p53 mutations in bladder tumors inactivate the transactivation of the p21 and Bax genes, and have a predictive value for the clinical outcome after bacillus Calmette-Guerin therapy.
The Journal of urology 1999;162(1):69-73.
1999: Christian Pfister; Jean-Michel Flaman; Cosette Martin; Philippe Grise; Thierry Frebourg
Selective detection of inactivating mutations of the tumor suppressor gene p53 in bladder tumors.
The Journal of urology 1999;161(6):1973-5.
1998: A Martin; Jean-Michel Flaman; T Frebourg; Frédéric Davi; S El Mansouri; J Amouroux; Martine Raphaël
Functional analysis of the p53 protein in AIDS-related non-Hodgkin's lymphomas and polymorphic lymphoproliferations.
British journal of haematology 1998;101(2):311-7.
1998: Jean-Michel Flaman; Valerie Robert; S Lenglet; V Moreau; Richard D Iggo; Thierry Frebourg
Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast.
Oncogene 1998;16(10):1369-72.
1997: F Waridel; A Estreicher; L Bron; Jean-Michel Flaman; C Fontolliet; P Monnier; Thierry Frebourg; Richard D Iggo
Field cancerisation and polyclonal p53 mutation in the upper aero-digestive tract.
Oncogene 1997;14(2):163-9.
1996: Jean-Michel Flaman; F Waridel; A Estreicher; A Vannier; J M Limacher; D Gilbert; Richard D Iggo; Thierry Frebourg
The human tumour suppressor gene p53 is alternatively spliced in normal cells.
Oncogene 1996;12(4):813-8.
1995: Dominique Campion; Jean-Michel Flaman; Alexis Brice; Didier Hannequin; Bruno Dubois; Cosette Martin; V Moreau; Frédéric Charbonnier; O Didierjean; Sandrine Tardieu
Mutations of the presenilin I gene in families with early-onset Alzheimer's disease.
Human molecular genetics 1995;4(12):2373-7.
1995: Jean-Michel Flaman; Thierry Frebourg; V Moreau; Frédéric Charbonnier; Cosette Martin; P Chappuis; A P Sappino; I M Limacher; L Bron; J Benhattar
A simple p53 functional assay for screening cell lines, blood, and tumors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(9):3963-7.
1995: Dominique Campion; Cosette Martin; Roland Heilig; Frédéric Charbonnier; V Moreau; Jean-Michel Flaman; JL Petit; Didier Hannequin; Alexis Brice; Thierry Frebourg
The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease.
Genomics 1995;26(2):254-7.
1994: Jean-Michel Flaman; Thierry Frebourg; V Moreau; Frédéric Charbonnier; Cosette Martin; C Ishioka; S H Friend; Richard D Iggo
A rapid PCR fidelity assay.
Nucleic acids research 1994;22(15):3259-60.