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Peter Flatt

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
83
O'Harte, Finbarr
50
Gault, Victor
49
Irwin, Nigel
43
Green, Brian
43
Abdel-Wahab, Yasser
41
McClenaghan, Neville
32
Harriott, Patrick
29
Barnett, Christopher
26
mooney, mark
20
McCluskey, Jane
19
Greer, Brett
18
Bailey, Clifford
17
McKillop, Aine
14
Ioannides, Costas
12
Marenah, Lamin

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Publications

TOP 3
Kerr Barry D; Irwin Nigel; O'Harte Finbarr P M; Bailey Clifford J; Flatt Peter R; Gault Victor A
Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties.
Irwin N; Flatt P R
Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications.
Irwin Nigel; Flatt Peter R
Therapeutic potential for GIP receptor agonists and antagonists.

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All Publications

2009: Kerr Barry D; Irwin Nigel; O'Harte Finbarr P M; Bailey Clifford J; Flatt Peter R; Gault Victor A
Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties.
Biochemical pharmacology 2009;78(8):1008-16.
2009: Irwin N; Flatt P R
Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications.
Diabetologia 2009;52(9):1724-31.
2009: Irwin Nigel; Flatt Peter R
Therapeutic potential for GIP receptor agonists and antagonists.
Best practice & research. Clinical endocrinology & metabolism 2009;23(4):499-512.
2009: Irwin N; McClean P L; Hunter K; Flatt P R
Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice.
Diabetes, obesity & metabolism 2009;11(6):603-10.
2009: Conlon J Michael; Abdel-Wahab Yasser H A; Flatt Peter R; Leprince Jérôme; Vaudry Hubert; Jouenne Thierry; Condamine Eric
A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae).
Peptides 2009;30(5):888-92.
2009: Flatt P R; Bailey C J; Green B D
Recent advances in antidiabetic drug therapies targeting the enteroinsular axis.
Current drug metabolism 2009;10(2):125-37.
2009: Irwin Nigel; Hunter Kerry; Frizzell Norma; Flatt Peter R
Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice.
Regulatory peptides 2009;153(1-3):70-6.
2009: Kerr Barry D; Irwin Nigel; Flatt Peter R; Gault Victor A
Prolonged GIP receptor activation using stable mini-PEGylated GIP improves glucose homeostasis and beta-cell function in age-related glucose intolerance.
Peptides 2009;30(2):219-25.
2009: McClenaghan Neville H; Scullion Siobhan M; Mion Brian; Hewage Chandralal; Malthouse J Paul G; Flatt Peter R; Newsholme Philip; Brennan Lorraine
Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.
Clinical science (London, England : 1979) 2009;116(4):341-51.
2008: Abdel-Wahab Yasser H A; Power Gavin J; Flatt Peter R; Woodhams Douglas C; Rollins-Smith Louise A; Conlon J Michael
A peptide of the phylloseptin family from the skin of the frog Hylomantis lemur (Phyllomedusinae) with potent in vitro and in vivo insulin-releasing activity.
Peptides 2008;29(12):2136-43.
2008: McClean P L; Irwin N; Hunter K; Gault V A; Flatt P R
(Pro(3))GIP[mPEG]: novel, long-acting, mPEGylated antagonist of gastric inhibitory polypeptide for obesity-diabetes (diabesity) therapy.
British journal of pharmacology 2008;155(5):690-701.
2008: Conlon J Michael; Power Gavin J; Abdel-Wahab Yasser H A; Flatt Peter R; Jiansheng Hu; Coquet Laurent; Leprince Jérôme; Jouenne Thierry; Vaudry Hubert
A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae).
Regulatory peptides 2008;151(1-3):153-9.
2008: Flatt P R
Dorothy Hodgkin Lecture 2008. Gastric inhibitory polypeptide (GIP) revisited: a new therapeutic target for obesity-diabetes?
Diabetic medicine : a journal of the British Diabetic Association 2008;25(7):759-64.
2008: Gault Victor A; Kerr Barry D; Irwin Nigel; Flatt Peter R
C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes.
Biochemical pharmacology 2008;75(12):2325-33.
2008: Irwin Nigel; Hunter Kerry; Flatt Peter R
Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice.
Peptides 2008;29(6):1036-41.
2008: Liu Hui-Kang; McCluskey Jane T; McClenghan Neville H; Flatt Peter R
Iterative exposure of clonal BRIN-BD11 cells to ninhydrin enables selection of robust toxin-resistant cells but with decreased gene expression of insulin secretory function.
Pancreas 2008;36(3):294-301.
2008: McClean P L; Gault V A; Irwin N; McCluskey J T; Flatt P R
Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP.
Diabetes, obesity & metabolism 2008;10(4):336-42.
2008: Taylor Ashley; Irwin Nigel; McKillop Aine M; Flatt Peter R; Gault Victor A
Sub-chronic administration of the 11beta-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity.
Biological chemistry 2008;389(4):441-5.
2008: Irwin Nigel; Hunter Kerry; Frizzell Norma; Flatt Peter R
Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice.
European journal of pharmacology 2008;581(1-2):226-33.
2008: Abdel-Wahab Yasser H A; Power Gavin J; Ng Ming T; Flatt Peter R; Conlon J Michael
Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue.
Biological chemistry 2008;389(2):143-8.
2008: Cassidy Roslyn S; Irwin Nigel; Flatt Peter R
Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets.
Biological chemistry 2008;389(2):189-93.
2008: McKillop Aine M; Duffy Nicola A; Lindsay John R; O'Harte Finbarr P M; Bell Patrick M; Flatt Peter R
Decreased dipeptidyl peptidase-IV activity and glucagon-like peptide-1(7-36)amide degradation in type 2 diabetic subjects.
Diabetes research and clinical practice 2008;79(1):79-85.
2008: Flatt Peter R; Bailey Clifford J; Green Brian D
Dipeptidyl peptidase IV (DPP IV) and related molecules in type 2 diabetes.
Frontiers in bioscience : a journal and virtual library 2008;13():3648-60.
2007: Green Brian D; Flatt Peter R
Incretin hormone mimetics and analogues in diabetes therapeutics.
Best practice & research. Clinical endocrinology & metabolism 2007;21(4):497-516.
2007: McClean Paula L; Irwin Nigel; Cassidy Roslyn S; Holst Jens J; Gault Victor A; Flatt Peter R
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1746-55.
2007: Irwin N; Hunter K; Flatt P R
Comparison of the metabolic effects of GIP receptor antagonism and PYY(3-36) receptor activation in high fat fed mice.
Peptides 2007;28(11):2192-8.
2007: Irwin Nigel; McClean Paula L; Cassidy Roslyn S; O'harte Finbarr P M; Green Brian D; Gault Victor A; Harriott Patrick; Flatt Peter R
Comparison of the anti-diabetic effects of GIP- and GLP-1-receptor activation in obese diabetic (ob/ob) mice: studies with DPP IV resistant N-AcGIP and exendin(1-39)amide.
Diabetes/metabolism research and reviews 2007;23(7):572-9.
2007: Liu Hui-Kang; McCluskey Jane T; McClenghan Neville H; Flatt Peter R
Streptozotocin-resistant BRIN-BD11 cells possess wide spectrum of toxin tolerance and enhanced insulin-secretory capacity.
Endocrine 2007;32(1):20-9.
2007: Gault V A; McClean P L; Cassidy R S; Irwin N; Flatt P R
Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.
Diabetologia 2007;50(8):1752-62.
2007: Gault Victor A; McClean Paula L; Irwin Nigel; Power Gavin J; McCluskey Janie T; Flatt Peter R
Effects of subchronic treatment with the long-acting glucose-dependent insulinotropic polypeptide receptor agonist, N-AcGIP, on glucose homeostasis in streptozotocin-induced diabetes.
Pancreas 2007;35(1):73-9.
2007: Duffy Nicola A; Green Brian D; Irwin Nigel; Gault Victor A; McKillop Aine M; O'Harte Finbarr P M; Flatt Peter R
Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1.
European journal of pharmacology 2007;568(1-3):278-86.
2007: Irwin N; McClean P L; O'Harte F P M; Gault V A; Harriott P; Flatt P R
Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice.
Diabetologia 2007;50(7):1532-40.
2007: Flatt Peter R
Effective surgical treatment of obesity may be mediated by ablation of the lipogenic gut hormone gastric inhibitory polypeptide (GIP): evidence and clinical opportunity for development of new obesity-diabetes drugs?
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007;4(2):151-3.
2007: Irwin Nigel; McClean Paula L; Flatt Peter R
Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice.
Journal of peptide science : an official publication of the European Peptide Society 2007;13(6):400-5.
2007: O'Harte Finbarr P M; Hunter Kerry; Gault Victor A; Irwin Nigel; Green Brian D; Greer Brett; Harriott Patrick; Bailey Clifford J; Flatt Peter R
Antagonistic effects of two novel GIP analogs, (Hyp3)GIP and (Hyp3)GIPLys16PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1674-82.
2007: Gault Victor A; Hunter Kerry; Irwin Nigel; Green Brian D; Greer Brett; Harriott Patrick; O'Harte Finbarr P M; Flatt Peter R
Characterisation and biological activity of Glu3 amino acid substituted GIP receptor antagonists.
Archives of biochemistry and biophysics 2007;461(2):263-74.
2007: Patterson Steven; Flatt Peter R; McClenaghan Neville H
Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic beta-cell glucose-sensing, cellular signal transduction and integrity.
Archives of biochemistry and biophysics 2007;461(2):287-93.
2007: Green B D; Irwin N; Flatt P R
Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice.
Peptides 2007;28(5):981-7.
2007: Patterson Steven; Scullion Siobhan M J; McCluskey Jane T; Flatt Peter R; McClenaghan Neville H
Prolonged exposure to homocysteine results in diminished but reversible pancreatic beta-cell responsiveness to insulinotropic agents.
Diabetes/metabolism research and reviews 2007;23(4):324-34.
2007: Irwin Nigel; McClean Paula L; Harriott Patrick; Flatt Peter R
Beneficial effects of sub-chronic activation of glucagon-like peptide-1 (GLP-1) receptors on deterioration of glucose homeostasis and insulin secretion in aging mice.
Experimental gerontology 2007;42(4):296-300.
2007: Hannan J M A; Ali L; Rokeya B; Khaleque J; Akhter M; Flatt P R; Abdel-Wahab Y H A
Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action.
The British journal of nutrition 2007;97(3):514-21.
2007: Parker Jeremy C; Irwin Nigel; Lavery Kerry S; Green Brian D; O'Harte Finbarr P M; Gault Victor A; Flatt Peter R
Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9-39)amide in obese diabetic (ob/ob) mice.
Biological chemistry 2007;388(2):221-6.
2007: Gault Victor A; Hunter Kerry; Irwin Nigel; Greer Brett; Green Brian D; Harriott Patrick; O'Harte Finbarr P M; Flatt Peter R
Characterisation and glucoregulatory actions of a novel acylated form of the (Pro3)GIP receptor antagonist in type 2 diabetes.
Biological chemistry 2007;388(2):173-9.
2007: Hannan J M A; Marenah Lamin; Ali Liaquat; Rokeya Begum; Flatt Peter R; Abdel-Wahab Yasser H
Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells.
The Journal of endocrinology 2007;192(1):159-68.
2007: Patterson Steven; Flatt Peter R; McClenaghan Neville H
Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase.
Pancreas 2007;34(1):144-51.
2007: Abdel-Wahab Yasser H A; Marenah Lamin; Flatt Peter R; Conlon J Michael
Insulin releasing properties of the temporin family of antimicrobial peptides.
Protein and peptide letters 2007;14(7):702-7.
2006: Green Brian D; Flatt Peter R; Bailey Clifford J
Dipeptidyl peptidase IV (DPP IV) inhibitors: A newly emerging drug class for the treatment of type 2 diabetes.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2006;3(3):159-65.
2006: Flatt P R; Green B D
Nutrient regulation of pancreatic beta-cell function in diabetes: problems and potential solutions.
Biochemical Society transactions 2006;34(Pt 5):774-8.
2006: Parker J C; Lavery K S; Irwin N; Green B D; Greer B; Harriott P; O'Harte F P M; Gault V A; Flatt P R
Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice.
The Journal of endocrinology 2006;191(1):93-100.
2006: Green Brian D; Irwin Nigel; Duffy Nicola A; Gault Victor A; O'harte Finbarr P M; Flatt Peter R
Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1.
European journal of pharmacology 2006;547(1-3):192-9.
2006: McClenaghan Neville H; Flatt Peter R; Ball Andrew J
Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide.
The Journal of endocrinology 2006;190(3):889-96.
2006: Conlon J Michael; Patterson Steven; Flatt Peter R
Major contributions of comparative endocrinology to the development and exploitation of the incretin concept.
Journal of experimental zoology. Part A, Comparative experimental biology 2006;305(9):781-6.
2006: Irwin Nigel; Clarke Gillian C; Green Brian D; Greer Brett; Harriott Patrick; Gault Victor A; O'Harte Finbarr P M; Flatt Peter R
Evaluation of the antidiabetic activity of DPP IV resistant N-terminally modified versus mid-chain acylated analogues of glucose-dependent insulinotropic polypeptide.
Biochemical pharmacology 2006;72(6):719-28.
2006: Green Brian D; Irwin Nigel; Cassidy Roslyn S; Gault Victor A; Flatt Peter R
Long-term administration of PACAP receptor antagonist, PACAP(6-27), impairs glucose tolerance and insulin sensitivity in obese diabetic ob/ob mice.
Peptides 2006;27(9):2343-9.
2006: Green Brian D; Lavery Kerry S; Irwin Nigel; O'harte Finbarr P M; Harriott Patrick; Greer Brett; Bailey Clifford J; Flatt Peter R
Novel glucagon-like peptide-1 (GLP-1) analog (Val8)GLP-1 results in significant improvements of glucose tolerance and pancreatic beta-cell function after 3-week daily administration in obese diabetic (ob/ob) mice.
The Journal of pharmacology and experimental therapeutics 2006;318(2):914-21.
2006: Marenah Lamin; McCluskey Jane T; Abdel-Wahab Yasser H A; O'Harte Finbarr P M; McClenaghan Neville H; Flatt Peter R
A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones.
Biological chemistry 2006;387(7):941-7.
2006: Hannan J M A; Ali L; Khaleque J; Akhter M; Flatt P R; Abdel-Wahab Y H A
Aqueous extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption.
The British journal of nutrition 2006;96(1):131-7.
2006: Irwin Nigel; Green Brian D; Parker Jeremy C; Gault Victor A; O'Harte Finbarr P M; Flatt Peter R
Biological activity and antidiabetic potential of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide, GIP(1-16) and (Pro3)GIP(1-16).
Regulatory peptides 2006;135(1-2):45-53.
2006: Patterson Steven; Flatt Peter R; McClenaghan Neville H
Homocysteine and other structurally-diverse amino thiols can alter pancreatic beta cell function without evoking cellular damage.
Biochimica et biophysica acta 2006;1760(7):1109-14.
2006: Green B D; Irwin N; Flatt P R
Pituitary adenylate cyclase-activating peptide (PACAP): assessment of dipeptidyl peptidase IV degradation, insulin-releasing activity and antidiabetic potential.
Peptides 2006;27(6):1349-58.
2006: Graham Ciaren; Richter Stephen C; McClean Stephen; O'Kane Edmund; Flatt Peter R; Shaw Chris
Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa.
Peptides 2006;27(6):1313-9.
2006: Patterson S; Flatt P R; Brennan L; Newsholme P; McClenaghan N H
Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.
The Journal of endocrinology 2006;189(2):301-10.
2006: Hannan J M A; Marenah L; Ali L; Rokeya B; Flatt P R; Abdel-Wahab Y H A
Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells.
The Journal of endocrinology 2006;189(1):127-36.
2006: Irwin Nigel; Green Brian D; Gault Victor A; Cassidy Roslyn S; O'Harte Finbarr P M; Harriott Patrick; Flatt Peter R
Effects on glucose homeostasis and insulin secretion of long term activation of the glucose-dependent insulinotropic polypeptide (GIP) receptor by N-AcGIP(LysPAL37) in normal mice.
Peptides 2006;27(4):893-900.
2006: Mathews Jacqueline N; Flatt Peter R; Abdel-Wahab Yasser H
Asparagus adscendens (Shweta musali) stimulates insulin secretion, insulin action and inhibits starch digestion.
The British journal of nutrition 2006;95(3):576-81.
2006: Liu Hui-Kang; Green Brian D; McClenaghan Neville H; McCluskey Jannie T; Flatt Peter R
Deleterious effects of supplementation with dehydroepiandrosterone sulphate or dexamethasone on rat insulin-secreting cells under in vitro culture condition.
Bioscience reports 2006;26(1):31-8.
2006: McKillop A M; Lindsay J R; Au S; Mahood K I; O'Harte F P M; Flatt P R; Bell P M
Meal-dependent regulation of circulating glycated insulin in type 2 diabetic subjects.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2006;38(2):94-7.
2006: Irwin Nigel; O'Harte Finbarr P M; Gault Victor A; Green Brian D; Greer Brett; Harriott Patrick; Bailey Clifford J; Flatt Peter R
GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential.
Journal of medicinal chemistry 2006;49(3):1047-54.
2006: Irwin Nigel; Green Brian D; Gault Victor A; Harriot Patrick; O'Harte Finbarr P M; Flatt Peter R
Stable agonist of glucose-dependent insulinotropic polypeptide (GIP) restores pancreatic beta cell glucose responsiveness but not glucose intolerance in aging mice.
Experimental gerontology 2006;41(2):151-6.
2006: Marenah L; Flatt P R; Orr D F; Shaw C; Abdel-Wahab Y H A
Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and brevinins-1E and -2EC with novel insulin releasing activity.
The Journal of endocrinology 2006;188(1):1-9.
2005: Marenah Lamin; Flatt Peter R; Orr David F; Shaw Chris; Abdel-Wahab Yasser H A
Isolation and structural characterization of novel Rugosin A-like insulinotropic peptide from the skin secretions of Rana saharica frog.
Peptides 2005;26(11):2117-23.
2005: Marenah L; Flatt P R; Orr D F; Shaw C; Abdel-Wahab Y H A
Characterization of naturally occurring peptides in the skin secretion of Rana pipiens frog reveal pipinin-1 as the novel insulin-releasing agent.
The journal of peptide research : official journal of the American Peptide Society 2005;66(4):204-10.
2005: Green B D; Gault V A; O'Harte F P M; Flatt P R
A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide.
Diabetes, obesity & metabolism 2005;7(5):595-604.
2005: Green B D; Liu H K; McCluskey J T; Duffy N A; O'Harte F P M; McClenaghan N H; Flatt P R
Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1.
Diabetes, obesity & metabolism 2005;7(5):563-9.
2005: Irwin Nigel; Green Brian D; Mooney Mark H; Greer Brett; Harriott Patrick; Bailey Clifford J; Gault Victor A; O'Harte Finbarr P M; Flatt Peter R
A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1187-94.
2005: Gault Victor A; Irwin Nigel; Green Brian D; McCluskey Jane T; Greer Brett; Bailey Clifford J; Harriott Patrick; O'harte Finbarr P M; Flatt Peter R
Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes.
Diabetes 2005;54(8):2436-46.
2005: Irwin Nigel; Gault Victor A; Green Brian D; Greer Brett; Harriott Patrick; Bailey Clifford J; Flatt Peter R; O'Harte Finbarr P M
Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37).
Biological chemistry 2005;386(7):679-87.
2005: Abdel-Wahab Yasser H A; Marenah Lamin; Orr David F; Shaw Chris; Flatt Peter R
Isolation and structural characterisation of a novel 13-amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer.
Biological chemistry 2005;386(6):581-7.
2005: Green B D; Irwin N; Gault V A; Bailey C J; O'Harte F P M; Flatt P R
Chronic treatment with exendin(9-39)amide indicates a minor role for endogenous glucagon-like peptide-1 in metabolic abnormalities of obesity-related diabetes in ob/ob mice.
The Journal of endocrinology 2005;185(2):307-17.
2005: Lindsay J R; Duffy N A; McKillop A M; Ardill J; O'Harte F P M; Flatt P R; Bell P M
Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2005;22(5):654-7.
2005: Graham Ciaren; Irvine Alexandra E; McClean Stephen; Richter Stephen C; Flatt Peter R; Shaw Chris
Peptide Tyrosine Arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin secretions of the dusky gopher frog, Rana sevosa.
Peptides 2005;26(5):737-43.
2005: Irwin Nigel; Green Brian D; Gault Victor A; Greer Brett; Harriott Patrick; Bailey Clifford J; Flatt Peter R; O'Harte Finbarr P M
Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide.
Journal of medicinal chemistry 2005;48(4):1244-50.
2005: Ball Andrew J; Flatt Peter R; McClenaghan Neville H
Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide.
Biochemical pharmacology 2005;69(1):59-63.
2004: Irwin Nigel; Gault Victor A; Green Brian D; Greer Brett; McCluskey Jane T; Harriott Patrick; O'Harte Finbarr P M; Flatt Peter R
Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice.
Biological chemistry 2004;385(9):845-52.
2004: Marenah L; McClean S; Flatt P R; Orr D F; Shaw C; Abdel-Wahab Y H A
Novel insulin-releasing peptides in the skin of Phyllomedusa trinitatis frog include 28 amino acid peptide from dermaseptin BIV precursor.
Pancreas 2004;29(2):110-5.
2004: Green B D; Gault V A; Flatt P R; Harriott P; Greer B; O'Harte F P M
Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.
Archives of biochemistry and biophysics 2004;428(2):136-43.
2004: Marenah L; Shaw C; Orr D F; McClean S; Flatt P R; Abdel-Wahab Y H A
Isolation and characterisation of an unexpected class of insulinotropic peptides in the skin of the frog Agalychnis litodryas.
Regulatory peptides 2004;120(1-3):33-8.
2004: Miguel João C; Patterson Steven; Abdel-Wahab Yasser H A; Mathias Paulo C F; Flatt Peter R
Time-correlation between membrane depolarization and intracellular calcium in insulin secreting BRIN-BD11 cells: studies using FLIPR.
Cell calcium 2004;36(1):43-50.
2004: Ball Andrew J; McCluskey Jane T; Flatt Peter R; McClenaghan Neville H
Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K(ATP) channel components.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;50(1):41-6.
2004: Ball Andrew J; Flatt Peter R; McClenaghan Neville H
Acute and long-term effects of nateglinide on insulin secretory pathways.
British journal of pharmacology 2004;142(2):367-73.
2004: Marenah L; Flatt P R; Orr D F; McClean S; Shaw C; Abdel-Wahab Y H A
Brevinin-1 and multiple insulin-releasing peptides in the skin of the frog Rana palustris.
The Journal of endocrinology 2004;181(2):347-54.
2004: Liu Hui-Kang; Green Brian D; McClenaghan Neville H; McCluskey Jane T; Flatt Peter R
Long-term beneficial effects of vanadate, tungstate, and molybdate on insulin secretion and function of cultured beta cells.
Pancreas 2004;28(4):364-8.
2004: Marenah Lamin; Flatt Peter R; Orr David F; McClean Steven; Shaw Chris; Abdel-Wahab Yasser H A
Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures.
Biological chemistry 2004;385(3-4):315-21.
2004: Murdock Diane J Lees; Clarke Jacqueline; Flatt Peter R; Barnett Yvonne A; Barnett Christopher R
Role of CYP2E1 in ketone-stimulated insulin release in pancreatic B-cells.
Biochemical pharmacology 2004;67(5):875-84.
2004: Green B D; Mooney M H; Gault V A; Irwin N; Bailey C J; Harriott P; Greer B; O'Harte F P M; Flatt P R
N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity.
The Journal of endocrinology 2004;180(3):379-88.
2004: Green Brian D; Gault Victor A; Mooney Mark H; Irwin Nigel; Harriott Patrick; Greer Brett; Bailey Cliff J; O'Harte Finbarr P M; Flatt Peter R
Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues.
Biological chemistry 2004;385(2):169-77.
2004: Liu Hui-Kang; Green Brian D; Flatt Peter R; McClenaghan Neville H; McCluskey Jane T
Effects of long-term exposure to nicotinamide and sodium butyrate on growth, viability, and the function of clonal insulin secreting cells.
Endocrine research 2004;30(1):61-8.
2004: Green B D; Mooney M H; Gault V A; Irwin N; Bailey C J; Harriott P; Greer B; Flatt P R; O'Harte F P M
Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).
Metabolism: clinical and experimental 2004;53(2):252-9.
2004: Green Brian D; Gault Victor A; O'harte Finbarr P M; Flatt Peter R
Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents.
Current pharmaceutical design 2004;10(29):3651-62.
2004: Liu Hui-Kang; Green Brian D; Gault Victor A; McCluskey Jane T; McClenaghan Neville H; O'Harte Finbarr P M; Flatt Peter R
N-acetyl-GLP-1: a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell-associated gene expression.
Cell biology international 2004;28(1):69-73.
2003: Green Brian D; Gault Victor A; Irwin Nigel; Mooney Mark H; Bailey Clifford J; Harriott Patrick; Greer Brett; Flatt Peter R; O'Harte Finbarr P M
Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1.
Biological chemistry 2003;384(12):1543-51.
2003: Green B D; Gault V A; Mooney M H; Irwin N; Bailey C J; Harriott P; Greer B; Flatt P R; O'Harte F P M
Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo.
Journal of molecular endocrinology 2003;31(3):529-40.
2003: Gault Victor A; O'Harte Finbarr P M; Flatt Peter R
Glucose-dependent insulinotropic polypeptide (GIP): anti-diabetic and anti-obesity potential?
Neuropeptides 2003;37(5):253-63.
2003: Lindsay J R; McKillop A M; Mooney M H; O'Harte F P M; Flatt P R; Bell P M
Effects of nateglinide on the secretion of glycated insulin and glucose tolerance in type 2 diabetes.
Diabetes research and clinical practice 2003;61(3):167-73.
2003: Gault Victor A; Flatt Peter R; O'Harte Finbarr P M
Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes.
Biochemical and biophysical research communications 2003;308(2):207-13.
2003: Gault Victor A; O'Harte Finbarr P M; Harriott Patrick; Flatt Peter R
Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo.
Metabolism: clinical and experimental 2003;52(6):679-87.
2003: Lindsay John R; McKillop Aine M; Mooney Mark H; Flatt Peter R; Bell Patrick M; O'harte Finbarr P M
Meal-induced 24-hour profile of circulating glycated insulin in type 2 diabetic subjects measured by a novel radioimmunoassay.
Metabolism: clinical and experimental 2003;52(5):631-5.
2003: McKillop Aine M; Meade Angela; Flatt Peter R; O'Harte Finbarr P M
Evaluation of the site(s) of glycation in human proinsulin by ion-trap LCQ electrospray ionization mass spectrometry.
Regulatory peptides 2003;113(1-3):1-8.
2003: Lindsay J R; McKillop A M; Mooney M H; O'Harte F P M; Bell P M; Flatt P R
Demonstration of increased concentrations of circulating glycated insulin in human Type 2 diabetes using a novel and specific radioimmunoassay.
Diabetologia 2003;46(4):475-8.
2003: Gault V A; O'Harte F P M; Harriott P; Mooney M H; Green B D; Flatt P R
Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin.
Diabetologia 2003;46(2):222-30.
2003: Hunter Steven J; Boyd Alison C; O'Harte Finbarr P M; McKillop Aine M; Wiggam M Ivan; Mooney Mark H; McCluskey Jane T; Lindsay John R; Ennis Cieran N; Gamble Raymond; Sheridan Brian; Barnett Christopher R; McNulty Helene; Bell Patrick M; Flatt Peter R
Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycemic-hyperinsulinemic clamp technique in humans.
Diabetes 2003;52(2):492-8.
2003: Gault V A; Flatt P R; Harriott P; Mooney M H; Bailey C J; O'Harte F P M
Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotrophic polypeptide.
The Journal of endocrinology 2003;176(1):133-41.
2003: Miguel João C; Abdel-Wahab Yasser H A; Green Brian D; Mathias Paulo C F; Flatt Peter R
Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity.
Biochemical pharmacology 2003;65(2):283-92.
2003: Gault V A; Irwin N; Harriott P; Flatt P R; O'Harte F P M
DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent insulinotropic polypeptide, (Ser2-Asp13)GIP.
Cell biology international 2003;27(1):41-6.
2002: Picton S F; McCluskey J T; Flatt P R; McClenaghan N H
Effects of cytotoxic agents on functional integrity and antioxidant enzymes in clonal beta-cells.
Diabetes & metabolism 2002;28(6 Pt 2):3S70-7; discussion 3S108-12.
2002: McKillop A M; Abdel-Wahab Y H A; Mooney M H; O'Harte F P M; Flatt P R
Secretion of glycated insulin from pancreatic beta-cells in diabetes represents a novel aspect of beta-cell dysfunction and glucose toxicity.
Diabetes & metabolism 2002;28(6 Pt 2):3S61-9; discussion 3S108-12.
2002: Gault V A; Parker J C; Harriott P; Flatt P R; O'Harte F P M
Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo.
The Journal of endocrinology 2002;175(2):525-33.
2002: Gault Victor A; Flatt Peter R; Bailey Clifford J; Harriott Patrick; Greer Brett; Mooney Mark H; O'harte Finbarr P M
Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes.
The Biochemical journal 2002;367(Pt 3):913-20.
2002: Gault V A; Harriott P; Flatt P R; O'Harte F P M
Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide.
Bioscience reports 2002;22(5-6):523-8.
2002: O'Harte F P M; Gault V A; Parker J C; Harriott P; Mooney M H; Bailey C J; Flatt P R
Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP.
Diabetologia 2002;45(9):1281-91.
2002: Abdel-Wahab Yasser H A; O'Harte Finbarr P M; Mooney Mark H; Barnett Christopher R; Flatt Peter R
Vitamin C supplementation decreases insulin glycation and improves glucose homeostasis in obese hyperglycemic (ob/ob) mice.
Metabolism: clinical and experimental 2002;51(4):514-7.
2002: Hamid M; McCluskey J T; McClenaghan N H; Flatt P R
Comparison of the secretory properties of four insulin-secreting cell lines.
Endocrine research 2002;28(1-2):35-47.
2002: Gault Victor A; O'Harte Finbarr P M; Harriott Patrick; Flatt Peter R
Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide.
Biochemical and biophysical research communications 2002;290(5):1420-6.
2002: Mooney Mark H; Abdel-Wahab Yasser H A; McKillop Aine M; O'Harte Finbarr P M; Flatt Peter R
Evaluation of glycated glucagon-like peptide-1(7-36)amide in intestinal tissue of normal and diabetic animal models.
Biochimica et biophysica acta 2002;1569(1-3):75-80.
2002: Miguel João C; Abdel-Wahab Yasser H A; Mathias Paulo C F; Flatt Peter R
Muscarinic receptor subtypes mediate stimulatory and paradoxical inhibitory effects on an insulin-secreting beta cell line.
Biochimica et biophysica acta 2002;1569(1-3):45-50.
2001: Mooney M H; Abdel-Wahab Y H; Morgan L M; O'Harte F P; Flatt P R
Detection of glycated gastric inhibitory polypeptide within the intestines of diabetic obese (ob/ob) mice.
Endocrine 2001;16(3):167-71.
2001: McKillop A M; Mooney M H; Harriott P; Flatt P R; O'Harte F P
Evaluation of glycated insulin in diabetic animals using immunocytochemistry and radioimmunoassay.
Biochemical and biophysical research communications 2001;286(3):524-8.
2001: Hamid M; McCluskey J T; McClenaghan N H; Flatt P R
Comparative functional study of clonal insulin-secreting cells cultured in five commercially available tissue culture media.
Cell transplantation 2001;10(2):153-9.
2001: McClenaghan N H; Ball A J; Flatt P R
Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure.
Biochemical pharmacology 2001;61(5):527-36.
2001: O'Harte F P; Mooney M H; Kelly C M; McKillop A M; Flatt P R
Degradation and glycemic effects of His(7)-glucitol glucagon-like peptide-1(7-36)amide in obese diabetic ob/ob mice.
Regulatory peptides 2001;96(3):95-104.
2001: Picton S F; Flatt P R; McClenaghan N H
Differential acute and long term actions of succinic acid monomethyl ester exposure on insulin-secreting BRIN-BD11 cells.
International journal of experimental diabetes research 2001;2(1):19-27.
2001: Hamid M; McCluskey J T; McClenaghan N H; Flatt P R
Functional examination of microencapsulated bioengineered insulin-secreting beta-cells.
Cell biology international 2001;25(6):553-6.
2000: Ball A J; Flatt P R; McClenaghan N H
Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14r and RX801080.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(6):575-9.
2000: Ball A J; Flatt P R; McClenaghan N H
Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide.
European journal of pharmacology 2000;408(3):327-33.
2000: O'Harte F P; Boyd A C; McKillop A M; Abdel-Wahab Y H; McNulty H; Barnett C R; Conlon J M; Højrup P; Flatt P R
Structure, antihyperglycemic activity and cellular actions of a novel diglycated human insulin.
Peptides 2000;21(10):1519-26.
2000: McKillop A M; McCluskey J T; Boyd A C; Mooney M H; Flatt P R; O'Harte F P
Production and characterization of specific antibodies for evaluation of glycated insulin in plasma and biological tissues.
The Journal of endocrinology 2000;167(1):153-63.
2000: Boyd A C; Abdel-Wahab Y H; McKillop A M; McNulty H; Barnett C R; O'Harte F P; Flatt P R
Impaired ability of glycated insulin to regulate plasma glucose and stimulate glucose transport and metabolism in mouse abdominal muscle.
Biochimica et biophysica acta 2000;1523(1):128-34.
2000: Hamid M; McCluskey J T; McClenaghan N H; Flatt P R
Culture and function of electrofusion-derived clonal insulin-secreting cells immobilized on solid and macroporous microcarrier beads.
Bioscience reports 2000;20(3):167-76.
2000: O'Harte F P; Mooney M H; Kelly C M; Flatt P R
Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide.
The Journal of endocrinology 2000;165(3):639-48.
2000: McClenaghan N H; Ball A J; Flatt P R
Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide.
British journal of pharmacology 2000;130(2):478-84.
2000: Ball A J; McCluskey J T; Flatt P R; McClenaghan N H
Drug-induced desensitization of insulinotropic actions of sulfonylureas.
Biochemical and biophysical research communications 2000;271(1):234-9.
2000: O'Harte F P; Mooney M H; Lawlor A; Flatt P R
N-terminally modified glucagon-like peptide-1(7-36) amide exhibits resistance to enzymatic degradation while maintaining its antihyperglycaemic activity in vivo.
Biochimica et biophysica acta 2000;1474(1):13-22.
2000: McClenaghan N H; Flatt P R
Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion.
Pancreas 2000;20(1):38-46.
2000: Gray A M; Abdel-Wahab Y H; Flatt P R
The traditional plant treatment, Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro.
The Journal of nutrition 2000;130(1):15-20.
1999: Abdel-Wahab Y H; O'Harte F P; Mooney M H; Conlon J M; Flatt P R
N-terminal glycation of cholecystokinin-8 abolishes its insulinotropic action on clonal pancreatic B-cells.
Biochimica et biophysica acta 1999;1452(1):60-7.
1999: McClenaghan N H; Flatt P R
Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin-secreting cell lines.
Diabetes, obesity & metabolism 1999;1(3):137-50.
1999: O'Harte F P; Mooney M H; Flatt P R
NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity.
Diabetes 1999;48(4):758-65.
1999: Gray A M; Flatt P R
Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander).
The British journal of nutrition 1999;81(3):203-9.
1999: Gray A M; Flatt P R
Insulin-secreting activity of the traditional antidiabetic plant Viscum album (mistletoe).
The Journal of endocrinology 1999;160(3):409-14.
1999: McClenaghan N H; Flatt P R
Engineering cultured insulin-secreting pancreatic B-cell lines.
Journal of molecular medicine (Berlin, Germany) 1999;77(1):235-43.
1999: McClenaghan N H; Flatt P R
Glucose and non-glucidic nutrients exert permissive effects on 2-keto acid regulation of pancreatic beta-cell function.
Biochimica et biophysica acta 1999;1426(1):110-8.
1998: Gray A M; Flatt P R
Antihyperglycemic actions of Eucalyptus globulus (Eucalyptus) are associated with pancreatic and extra-pancreatic effects in mice.
The Journal of nutrition 1998;128(12):2319-23.
1998: O'Harte F P; Abdel-Wahab Y H; Conlon J M; Flatt P R
Amino terminal glycation of gastric inhibitory polypeptide enhances its insulinotropic action on clonal pancreatic B-cells.
Biochimica et biophysica acta 1998;1425(2):319-27.
1998: O'Harte F P; Abdel-Wahab Y H; Conlon J M; Flatt P R
Glycation of glucagon-like peptide-1(7-36)amide: characterization and impaired action on rat insulin secreting cells.
Diabetologia 1998;41(10):1187-93.
1998: O'Harte F P; Mooney M H; Kelly C M; Flatt P R
Glycated cholecystokinin-8 has an enhanced satiating activity and is protected against enzymatic degradation.
Diabetes 1998;47(10):1619-24.
1998: McClenaghan N H; Barnett C R; Flatt P R
Na+ cotransport by metabolizable and nonmetabolizable amino acids stimulates a glucose-regulated insulin-secretory response.
Biochemical and biophysical research communications 1998;249(2):299-303.
1998: Gray A M; Flatt P R
Actions of the traditional anti-diabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion.
The British journal of nutrition 1998;80(1):109-14.
1998: Gray A M; Flatt P R
Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom).
The Journal of endocrinology 1998;157(2):259-66.
1998: O'Harte F P; Abdel-Wahab Y H; Conlon J M; Flatt P R
Glycated IAPP shows a reduced inhibitory action on insulin secretion.
Biochemical Society transactions 1998;26(1):S6.
1998: O'Harte F P; Gray A M; Flatt P R
Gastric inhibitory polypeptide and effects of glycation on glucose transport and metabolism in isolated mouse abdominal muscle.
The Journal of endocrinology 1998;156(2):237-43.
1998: McClenaghan N H; Flatt P R; Bailey C J
Insulin-releasing action of the novel antidiabetic agent BTS 67 582.
British journal of pharmacology 1998;123(3):400-4.
1997: Abdel-Wahab Y H; O'Harte F P; Boyd A C; Barnett C R; Flatt P R
Glycation of insulin results in reduced biological activity in mice.
Acta diabetologica 1997;34(4):265-70.
1997: Gray A M; Flatt P R
Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne).
The British journal of nutrition 1997;78(2):325-34.
1997: Clarke J; Flatt P R; Barnett C R
Cytochrome P450 1A-like proteins expressed in the islets of Langerhans and altered pancreatic beta-cell secretory responsiveness.
British journal of pharmacology 1997;121(3):389-94.
1997: Gray A M; Flatt P R
Nature's own pharmacy: the diabetes perspective.
The Proceedings of the Nutrition Society 1997;56(1B):507-17.
1997: Flatt P R; Abdel-Wahab Y H; Boyd A C; Barnett C R; O'Harte F P
Pancreatic B-cell dysfunction and glucose toxicity in non-insulin-dependent diabetes.
The Proceedings of the Nutrition Society 1997;56(1B):243-62.
1997: O'Harte F P; Penney A C; Flatt P R
Glycation of insulin by phosphorylated and nonphosphorylated reducing sugars.
Biochemical Society transactions 1997;25(1):150S.
1997: McDonagh M; Ali L; Kahn A; Flatt P R; Barnett Y A; Barnett C R
Antioxidant status, oxidative stress and DNA damage in the aetiology of malnutrition related diabetes mellitus.
Biochemical Society transactions 1997;25(1):146S.
1997: McClenaghan N H; Barnett C R; Flatt P R
Mechanisms of action of cationic amino acids on insulin-secreting BRIN-BD11 cells.
Biochemical Society transactions 1997;25(1):144S.
1997: Clarke J; Coulter J; Flatt P R; Barnett C R
Islet antioxidant and second phase enzyme levels following CYP1A, CYP2E, CYP2B and CYP4A induction.
Biochemical Society transactions 1997;25(1):133S.
1997: Abdel-Wahab Y H; O'Harte F P; Barnett C R; Flatt P R
Glycation of insulin in a cultured insulin-secreting cell line.
Biochemical Society transactions 1997;25(1):128S.
1997: Clarke J C; Flatt P R; Barnett C R
The role of cytochrome P450 in altered pancreatic B-cell responsiveness.
Biochemical Society transactions 1997;25(1):122S.
1997: Abdel-Wahab Y H; O'Harte F P; Barnett C R; Flatt P R
Characterization of insulin glycation in insulin-secreting cells maintained in tissue culture.
The Journal of endocrinology 1997;152(1):59-67.
1997: Wilson A M; Barnett C R; Flatt P R
Altered secretory responsiveness of BRIN-BD11 cells cultured under hyperglycaemic conditions is not readily reversed by subsequent culture in lower glucose concentrations.
Advances in experimental medicine and biology 1997;426():379-84.
1997: O'Harte F P; Gray A M; Abdel-Wahab Y H; Flatt P R
Effects of non-glycated and glycated glucagon-like peptide-1(7-36) amide on glucose metabolism in isolated mouse abdominal muscle.
Peptides 1997;18(9):1327-33.
1996: Clarke J; Snelling J; Ioannides C; Flatt P R; Barnett C R
Effect of vitamin C supplementation on hepatic cytochrome P450 mixed-function oxidase activity in streptozotocin-diabetic rats.
Toxicology letters 1996;89(3):249-56.
1996: McClenaghan N H; Barnett C R; O'Harte F P; Flatt P R
Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line.
The Journal of endocrinology 1996;151(3):349-57.
1996: Abdel-Wahab Y H; O'Harte F P; Ratcliff H; McClenaghan N H; Barnett C R; Flatt P R
Glycation of insulin in the islets of Langerhans of normal and diabetic animals.
Diabetes 1996;45(11):1489-96.
1996: McClenaghan N H; Barnett C R; Ah-Sing E; Abdel-Wahab Y H; O'Harte F P; Yoon T W; Swanston-Flatt S K; Flatt P R
Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion.
Diabetes 1996;45(8):1132-40.
1996: McClenaghan N H; Gray A M; Barnett C R; Flatt P R
Hexose recognition by insulin-secreting BRIN-BD11 cells.
Biochemical and biophysical research communications 1996;223(3):724-8.
1996: Flatt P R
Pancreatic B-cells as mediators of metabolic effects of regulatory peptides.
Biochemical Society transactions 1996;24(2):570-5.
1996: McClenaghan N H; Barnett C R; O'Harte F P; Swanston-Flatt S K; Ah-Sing E; Flatt P R
Characteristics of BRIN-BG5 and BRIN-BG7, two novel glucose-responsive insulin-secreting cell lines produced by electrofusion.
The Journal of endocrinology 1996;148(3):409-17.
1996: McClenaghan N H; Barnett C R; Ah-Sing E; Swanston-Flatt S K; Flatt P R
Secretory properties of clonal insulin-secreting BRIN-BG5 cells, produced by electrofusion.
Biochemical Society transactions 1996;24(1):101S.
1996: O'Harte F P; Højrup P; Barnett C R; Flatt P R
Identification of the site of glycation of human insulin.
Peptides 1996;17(8):1323-30.
1995: Irizar A; Barnett C R; Flatt P R; Ioannides C
Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat.
European journal of pharmacology 1995;293(4):385-93.
1994: O'Harte F P; Boyd A C; Abdel-Wahab Y H; Barnett C R; Flatt P R
Characterization of the glycation of human insulin by reversed-phase HPLC.
Biochemical Society transactions 1994;22(2):239S.
1994: Abdel-Wahab Y H; O'Harte F P; Barnett C R; Flatt P R
Studies of the effect of glycation of insulin on glucose metabolism in isolated mouse diaphragm muscle.
Biochemical Society transactions 1994;22(2):238S.
1994: McClenaghan N H; Yoon T W; Barnett C R; Wilson A M; Abdel-Wahab Y H; Swanston-Flatt S; Ah-Singh E; Flatt P R
Effect of glucose and amino acids on insulin-secretion from a novel pancreatic B-cell line produced by electrofusion.
Biochemical Society transactions 1994;22(2):237S.
1994: Barnett C R; Flatt P R; Ioannides C
Modulation of the rat hepatic cytochrome P450 composition by long-term streptozotocin-induced insulin-dependent diabetes.
Journal of biochemical toxicology 1994;9(2):63-9.
1994: Flatt P R; Shibier O; Szecowka J; Berggren P O
New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic beta-cell.
Diabète & métabolisme 1994;20(2):157-62.
1994: Flatt P R; Barnett C R; Swanston-Flatt S K
Mechanisms of pancreatic B-cell dysfunction and glucose toxicity in non-insulin-dependent diabetes.
Biochemical Society transactions 1994;22(1):18-23.
1994: McDermott B M; Flatt P R; Strain J J
Effects of copper deficiency and experimental diabetes on tissue antioxidant enzyme levels in rats.
Annals of nutrition & metabolism 1994;38(5):263-9.
1993: Barnett C R; Rudd S; Flatt P R; Ioannides C
Sex differences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins.
Biochemical pharmacology 1993;45(2):313-9.
1992: Barnett C R; Petrides L; Wilson J; Flatt P R; Ioannides C
Induction of rat hepatic mixed-function oxidases by acetone and other physiological ketones: their role in diabetes-induced changes in cytochrome P450 proteins.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(12):1441-50.
1992: Barnett C R; Abbott R A; Bailey C J; Flatt P R; Ioannides C
Cytochrome P-450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes.
Biochemical pharmacology 1992;43(8):1868-71.
1992: Barnett C R; Wilson J; Wolf C R; Flatt P R; Ioannides C
Hyperinsulinaemia causes a preferential increase in hepatic P4501A2 activity.
Biochemical pharmacology 1992;43(6):1255-61.
1991: Swanston-Flatt S K; Flatt P R; Day C; Bailey C J
Traditional dietary adjuncts for the treatment of diabetes mellitus.
The Proceedings of the Nutrition Society 1991;50(3):641-51.
1991: Flatt P R; Barnett C R; Shibier O; Swanston-Flatt S K
Direct and indirect actions of nutrients in the regulation of insulin secretion from the pancreatic beta cells.
The Proceedings of the Nutrition Society 1991;50(3):559-66.
1991: Flatt P R; Bailey C J; Conlon J M
Somatostatin, gastrin-releasing peptide and gastrin in the stomach of rats with streptozotocin-induced diabetes and insulinoma.
The Journal of nutrition 1991;121(9):1414-7.
1991: Flatt P R; Kwasowski P; Howland R J; Bailey C J
Gastric inhibitory polypeptide and insulin responses to orally administered amino acids in genetically obese hyperglycemic (ob/ob) mice.
The Journal of nutrition 1991;121(7):1123-8.
1990: Swanston-Flatt S K; Day C; Bailey C J; Flatt P R
Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice.
Diabetologia 1990;33(8):462-4.
1990: Barnett C R; Flatt P R; Ioannides C
Induction of hepatic microsomal P450 I and IIB proteins by hyperketonaemia.
Biochemical pharmacology 1990;40(2):393-7.
1990: Barnett C R; Gibson G G; Wolf C R; Flatt P R; Ioannides C
Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes.
The Biochemical journal 1990;268(3):765-9.
1990: Ioannides C; Ayrton A D; Keele A; Lewis D F; Flatt P R; Walker R
Mechanism of the in vitro antimutagenic action of retinol.
Mutagenesis 1990;5(3):257-62.
1990: Flatt P R
Defective regulation of insulin secretion in diabetes and insulinoma.
Biochemical Society transactions 1990;18(1):124-7.
1990: Flatt P R; Shiber O; Hampton S M; Marks V
Stimulatory effects of glucagon-like peptides on human insulinoma cells and insulin-releasing clonal RINm5F cells.
Diabetes research (Edinburgh, Scotland) 1990;13(2):55-9.
1990: Flatt P R; Bailey C J; Kwasowski P; Swanston-Flatt S K
Effects of diets rich in sucrose, coconut fat and safflowerseed oil on the development of the obese hyperglycaemic (ob/ob) syndrome in mice.
Diabetes research (Edinburgh, Scotland) 1990;13(1):23-8.
1990: Barnett C R; Flatt P R; Ioannides C
Hyperketonaemia markedly modulates the metabolic activation of chemical carcinogens.
Chemico-biological interactions 1990;74(3):281-9.
1989: Flatt P R; Kwasowski P; Bailey C J
Stimulation of gastric inhibitory polypeptide release in ob/ob mice by oral administration of sugars and their analogues.
The Journal of nutrition 1989;119(9):1300-3.
1989: Flatt P R; Shibier O; Ioannides C; Swanston-Flatt S K
Studies on the chemical and immunological destruction of insulin-secreting islet cell tumours.
Experimental and clinical endocrinology 1989;93(2-3):193-202.
1989: Flatt P R; Juntti-Berggren L; Berggren P O; Gould B J; Swanston-Flatt S K
Failure of glucose tolerance factor-containing Brewer's yeast to ameliorate spontaneous diabetes in C57BL/KsJ DB/DB mice.
Diabetes research (Edinburgh, Scotland) 1989;10(3):147-51.
1989: Flatt P R; Juntti-Berggren L; Berggren P O; Gould B J; Swanston-Flatt S K
Effects of dietary inorganic trivalent chromium (Cr3+) on the development of glucose homeostasis in rats.
Diabète & métabolisme 1989;15(2):93-7.
1989: Swanston-Flatt S K; Day C; Flatt P R; Gould B J; Bailey C J
Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice.
Diabetes research (Edinburgh, Scotland) 1989;10(2):69-73.
1989: Flatt P R; Bass S L; Ayrton A D; Trinick J; Ioannides C
Metabolic activation of chemical carcinogens by hepatic preparations from streptozotocin-treated rats.
Diabetologia 1989;32(2):135-9.
1989: Swanston-Flatt S K; Day C; Bailey C J; Flatt P R
Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice.
Acta diabetologica latina 1989;26(1):51-5.
1988: Barnett C R; Flatt P R; Ioannides C
Role of ketone bodies in the diabetes-induced changes in hepatic mixed-function oxidase activities.
Biochimica et biophysica acta 1988;967(2):250-4.
1988: Flatt P R; DeSilva M G; Swanston-Flatt S K; Powell C J; Marks V
Tumour formation and insulin secretion by clonal RINm5F cells following repeated subcutaneous transplantation in NEDH rats.
The Journal of endocrinology 1988;118(3):429-37.
1988: Flatt P R; Abrahamsson H; Arkhammar P; Berggren P O; Rorsman P; Swanston-Flatt S K
Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture.
British journal of cancer 1988;58(1):22-9.
1988: Ioannides C; Bass S L; Ayrton A D; Trinick J; Walker R; Flatt P R
Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens.
Chemico-biological interactions 1988;68(3-4):189-202.
1988: Swanston-Flatt S K; Flatt P R
Effects of cationic modification on 45Ca uptake and insulin release by transplantable rat insulinoma cells maintained in tissue culture.
General pharmacology 1988;19(3):471-4.
1988: Swanston-Flatt S K; Flatt P R
Effects of amino acids, hormones and drugs on insulin release and 45Ca uptake by transplantable rat insulinoma cells maintained in tissue culture.
General pharmacology 1988;19(2):239-42.
1987: Flatt P R; DeSilva M; Swanston-Flatt S K; Marks V
Insulin secretion in vivo and in vitro from transplantable NEDH rat insulinoma and derived clonal RINm5F cell line.
Diabetes research (Edinburgh, Scotland) 1987;6(2):85-90.
1987: Flatt P R; Swanston-Flatt S K; Powell C J; Marks V
Defective regulation of insulin release and transmembrane Ca2+ fluxes by human islet cell tumours.
British journal of cancer 1987;56(4):459-64.
1987: Flatt P R; Swanston-Flatt S K; Snell K; Tan K S; Marks V
Effects of diet-induced ketosis in rats with hypoglycaemia due to a serially transplantable insulinoma.
Diabète & métabolisme 1987;13(5):503-7.
1987: Flatt P R; Bailey C J; Swanston-Flatt S K; Tan K S; Marks V
Reversal of diabetes by syngeneic transplantation of a radiation-induced rat insulinoma.
Diabetes research and clinical practice 1987;3(2):63-9.
1987: Flatt P R; Tan K S; Swanston-Flatt S K; Bailey C J; Marks V
Defective diurnal changes of food intake, plasma glucose and insulin in rats with a transplantable islet cell tumour.
Hormone research 1987;27(1):47-52.
1987: Flatt P R; Swanston-Flatt S K; Tan K S; Marks V
Effects of cytotoxic drugs and inhibitors of insulin secretion on a serially transplantable rat insulinoma and cultured rat insulinoma cells.
General pharmacology 1987;18(3):293-7.
1987: Flatt P R; Tan K S; Swanston-Flatt S K; Webster J D; Marks V
Metabolic effects and secretory properties of a radiation-induced transplantable rat insulinoma.
Comparative biochemistry and physiology. A, Comparative physiology 1987;87(1):175-81.
1986: Gould B J; Flatt P R; Kotecha S; Collett S; Swanston-Flatt S K
Measurement of glycosylated haemoglobins and glycosylated plasma proteins in animal models with diabetes or inappropriate hypoglycaemia.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1986;18(12):795-9.
1986: Flatt P R; Tan K S; Bailey C J; Powell C J; Swanston-Flatt S K; Marks V
Effects of transplantation and resection of a radiation-induced rat insulinoma on glucose homeostasis and the endocrine pancreas.
British journal of cancer 1986;54(4):685-92.
1983: Flatt P R; Bailey C J; Kwasowski P; Swanston-Flatt S K; Marks V
Abnormalities of GIP in spontaneous syndromes of obesity and diabetes in mice.
Diabetes 1983;32(5):433-5.

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