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Richard Flavell

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Lauren A Zenewicz; Liping Zhao; Eran Elinav; Liming Hao; Guoyang Wang; Xiaochen Yin; Richard A Flavell
IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic.
Jorge Henao-Mejia; Till Strowig; Richard A Flavell
Microbiota keep the intestinal clock ticking.
Heather M McGee; Andrew J Murphy; Barbara A Schmidt; Sean Stevens; David M Valenzuela; George D Yancopoulos; Carmen J Booth; Richard A Flavell; Valerie Horsley
IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin.

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2013: Lauren A Zenewicz; Liping Zhao; Eran Elinav; Liming Hao; Guoyang Wang; Xiaochen Yin; Richard A Flavell
IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(10):5306-12.
2013: Jorge Henao-Mejia; Till Strowig; Richard A Flavell
Microbiota keep the intestinal clock ticking.
Cell 2013;153(4):741-3.
2013: Heather M McGee; Andrew J Murphy; Barbara A Schmidt; Sean Stevens; David M Valenzuela; George D Yancopoulos; Carmen J Booth; Richard A Flavell; Valerie Horsley
IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin.
The Journal of investigative dermatology 2013;133(5):1321-9.
2013: Adam Williams; Stephanie C Eisenbarth; Soo Seok Hwang; Gap Ryol Lee; Charalampos G Spilianakis; Richard A Flavell
Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(17):6955-60.
2013: Harumichi Ishigame; Warren J Leonard; Paula Licona-Limón; Maki Nakayama; Shomyseh Sanjabi; Lauren A Zenewicz; Richard A Flavell
Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(17):6961-6.
2013: Christopher L Case; Marcel R de Zoete; Richard A Flavell; Lara J Kohler; Jonilson B Lima; Till Strowig; Dario S Zamboni; Craig R Roy
Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1851-6.
2013: Myoung Sook Han; Dae Young Jung; Jason K Kim; Saquib A Lakhani; Caroline Morel; Richard A Flavell; Roger J Davis
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation.
Science (New York, N.Y.) 2013;339(6116):218-22.
2013: Jorge Henao-Mejia; Christoph A Thaiss; Eran Elinav; Richard A Flavell
The intestinal microbiota in chronic liver disease.
Advances in immunology 2013;117():73-97.
2013: Eran Elinav; J Henao-Mejia; Richard A Flavell
Integrative inflammasome activity in the regulation of intestinal mucosal immune responses.
Mucosal immunology 2013;6(1):4-13.
2013: Jincy M Issac; Yassir A Mohamed; Dhanya Sarawathiamma; Mai I Al-Ketbi; Samia M Al-Ojali; Sheikh Azimullah; Maria J Fernandez-Cabezudo; Richard A Flavell; Basel K al-Ramadi
Differential outcome of infection with attenuated Salmonella in MyD88-deficient mice is dependent on the route of administration.
Immunobiology 2013;218(1):52-63.
2012: Marcel R de Zoete; Richard A Flavell
NLRP1 joins the dark side?
Immunity 2012;37(6):950-2.
2012: Sophie Joly; Daniel H Kaplan; Alicia K Olivier; Suzanne L Cassel; Stephanie C Eisenbarth; Richard A Flavell; Adam Williams; Fayyaz S Sutterwala
Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(10):4713-7.
2012: Samuel Huber; Andrew J Murphy; William O'Connor; Wenjun Ouyang; David M Valenzuela; George D Yancopoulos; Lauren A Zenewicz; Wei Zhang; Clara Abraham; Carmen J Booth; Lidia Bosurgi; Judy H Cho; Nicola Gagliani; Matija Hedl; Bo Hu; Francis J Huber; Richard A Flavell
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.
Nature 2012;491(7423):259-63.
2012: Bindu Sukumaran; Richard A Flavell; Koichi S Kobayashi; Yasunori Ogura; Joao H F Pedra; Erol Fikrig
Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection.
FEMS immunology and medical microbiology 2012;66(2):211-9.
2012: Jason Park; Ragy Ragheb; Eric Stern; Stephen H Wrzesinski; Atu Agawu; Jason Criscione; Stacey L Demento; Anthony F Ferrandino; Richard A Flavell; David Gonzalez; Ann Habermann; Steven M Jay; Paula Licona Limon; Michael Look; Tarek M Fahmy
Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy.
Nature materials 2012;11(10):895-905.
2012: Xindong Liu; Natalia Martin-Orozco; Roza I Nurieva; Qiang Tian; Aibo Wang; Xiaohu Wang; Yihong Wang; Xiaowei Yan; Bo Zhong; Seon Hee Chang; Enric Esplugues; Richard A Flavell; Chen Dong
Bcl6 expression specifies the T follicular helper cell program in vivo.
The Journal of experimental medicine 2012;209(10):1841-52, S1-24.
2012: Samuel Huber; Nicola Gagliani; Richard A Flavell
Life, death, and miracles: Th17 cells in the intestine.
European journal of immunology 2012;42(9):2238-45.
2012: Frank Wegmann; Adam Williams; Erin M Scherer; Neil C Sheppard; Catharina Svanborg; Joseph N Blattman; Sarah A Brinckmann; Margherita Coccia; Suzanne Cole; Richard A Flavell; Kate H Gartlan; Philip D Greenberg; Ali M Harandi; William R Hillson; Ling-Pei Ho; Wai Ling Kok; George Krashias; Teresa Lambe; Amin E Moghaddam; Manoj Puthia; Quentin J Sattentau
Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens.
Nature biotechnology 2012;30(9):883-8.
2012: Anette Hübner; Maria Karasarides; David J Mulholland; Charles L Sawyers; Claire L Standen; Cathy Tournier; Hong Wu; Tamera Barrett; Julie Cavanagh-Kyros; Hongbo Chi; Richard A Flavell; Dale L Greiner; Roger J Davis
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(30):12046-51.
2012: Megan Noelle Ballinger; Urvashi Bhan; Richard A Flavell; Jeffrey C Horowitz; Bethany B Moore; Michael W Newstead; David J Pinsky; Xianying Zeng; Theodore J Standiford
TLR signaling prevents hyperoxia-induced lung injury by protecting the alveolar epithelium from oxidant-mediated death.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(1):356-64.
2012: Aleh Bobr; Richard A Flavell; Krystal M Haley; Botond Z Igyarto; Ming O Li; Daniel H Kaplan
Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10492-7.
2012: Jan Czyzyk; Enric Esplugues; Christine Fedorchuk; Frans K Gorus; Octavian Henegariu; Kevan Herold; Paula Preston-Hurlburt; Raman Baldzizhar; Kim Bottomly; Richard A Flavell
Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6319-27.
2012: Kevin B Walsh; Megan J Welch; E John Wherry; Elina I Zuniga; Shawn D Blackburn; Richard A Flavell; Daniel M Fremgen; John R Teijaro; Karl F von Tiehl; Michael B A Oldstone
Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection.
Cell host & microbe 2012;11(6):643-53.
2012: Tim Willinger; Richard A Flavell
Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8670-5.
2012: Feng Qian; John W Christman; Jing Deng; Chen Dong; Richard A Flavell; Benjamin Nicholas Gantner; Richard D Ye
Map kinase phosphatase 5 protects against sepsis-induced acute lung injury.
American journal of physiology. Lung cellular and molecular physiology 2012;302(9):L866-74.
2012: Stephanie C Eisenbarth; Eran Elinav; Oscar R Colegio; David G Gonzalez; Ann M Haberman; Jorge Henao-Mejia; Sophie Joly; Steven H Kleinstein; Hailong Meng; Anthony Rongvaux; Till Strowig; Fayyaz S Sutterwala; Christoph A Thaiss; Adam Williams; Lan Xu; Lauren A Zenewicz; Richard A Flavell
NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.
Nature 2012;484(7395):510-3.
2012: Jorge Henao-Mejia; Till Strowig; Eran Elinav; Richard A Flavell
Inflammasomes: far beyond inflammation.
Nature immunology 2012;13(4):321-4.
2012: Srinivas Koduru; David G Schatz; Matthew P Strout; Till Strowig; Ranjini Sundaram; Ellice Wong; Lin Zhang; Kavita M Dhodapkar; Richard A Flavell; Madhav V Dhodapkar
Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.
Blood 2012;119(10):2302-9.
2012: Martin A Kriegel; Chozhavendan Rathinam; Richard A Flavell
Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(9):3457-62.
2012: Melissa A Kinnebrew; Ingrid Leiner; Dan R Littman; Charlie G Buffie; Gretchen E Diehl; Richard A Flavell; Tobias M Hohl; Lauren A Zenewicz; Eric G Pamer
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.
Immunity 2012;36(2):276-87.
2012: Jorge Henao-Mejia; Hal M Hoffman; Chengcheng Jin; Michael J Jurczak; Andrew L Kau; Wajahat Z Mehal; Gerald I Shulman; Till Strowig; Christoph A Thaiss; Joao-Paulo Camporez; Stephanie C Eisenbarth; Eran Elinav; Jeffrey I Gordon; Liming Hao; Richard A Flavell
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Nature 2012;482(7384):179-85.
2012: Nicola Gagliani; Samuel Huber; Richard A Flavell
The Intestine: where amazing things happen.
Cell research 2012;22(2):277-9.
2012: Namiko Hoshi; Akiko Iwasaki; Richard A Flavell; James G Fox; Nicola Gagliani; Simone A Nish; Boris Reizis; Dominik Schenten; Zeli Shen; Zenta Walther; Ruslan Medzhitov
MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice.
Nature communications 2012;3():1120.
2012: Penghua Wang; Long Yang; Xiaoling Yuan; Lauren A Zenewicz; Fengwei Bai; Gong Cheng; Jianfeng Dai; Richard A Flavell; David Gate; Ruth R Montgomery; Feng Qian; Terrence Town; Erol Fikrig
IL-22 signaling contributes to West Nile encephalitis pathogenesis.
PloS one 2012;7(8):e44153.
2012: Wei Zhang; Hongyu Zhao; Clara Abraham; Enric Esplugues; John Ferguson; Richard A Flavell; Gerald Goh; Ken Hui; Aiping Lin; Sok Meng Ng; Judy H Cho
Effector CD4+ T cell expression signatures and immune-mediated disease associated genes.
PloS one 2012;7(6):e38510.
2011: Maciej Lech; Javier Martin; Mi Ryu; Ekaterina Vlasova; David Anz; Stefan Endres; Richard A Flavell; Jürgen Heesemann; Claudia Kantner; Koichi S Kobayashi; Onkar P Kulkarni; Hans-Joachim Anders
Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus.
Annals of the rheumatic diseases 2011;70(12):2207-17.
2011: Shashi Kant; Benjamin G Neel; Wojciech Swat; Sheng Zhang; Zhong-Yin Zhang; Richard A Flavell; Roger J Davis
TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Genes & development 2011;25(19):2069-78.
2011: Tom L Van Belle; Enric Esplugues; Richard A Flavell; Therese Juntti; Jeanette Liao; Matthias G von Herrath
Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):2915-22.
2011: Chozhavendan Rathinam; Jose Rojas; Anthony Rongvaux; David M Valenzuela; George D Yancopoulos; Elizabeth Eynon; Markus G Manz; Andrew J Murphy; William T Poueymirou; Richard A Flavell
Efficient differentiation and function of human macrophages in humanized CSF-1 mice.
Blood 2011;118(11):3119-28.
2011: Chengcheng Jin; Richard Pelker; Agnès Vignery; Diane Cwirka; Stephanie C Eisenbarth; Patrick Frayssinet; Bo Hu; Richard A Flavell
NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(36):14867-72.
2011: Till Strowig; Hitoshi Takizawa; Chiara Borsotti; Elizabeth Eynon; Markus G Manz; William Philbrick; Chozhavendan Rathinam; Anthony Rongvaux; Richard A Flavell
Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(32):13218-23.
2011: Enric Esplugues; Jeffrey A Bluestone; Nicola Gagliani; Ann M Haberman; Anja E Hauser; Kevan C Herold; Samuel Huber; Yoichiro Iwakura; Jay K Kolls; Vijay K Kuchroo; William O'Connor; Anthony Rongvaux; Terrence Town; Nico van Rooijen; Yisong Y Wan; Richard A Flavell
Control of TH17 cells occurs in the small intestine.
Nature 2011;475(7357):514-8.
2011: Tim Willinger; Markus G Manz; Anthony Rongvaux; Till Strowig; Richard A Flavell
Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement.
Trends in immunology 2011;32(7):321-7.
2011: Jennifer L Ather; Jonathan Boyson; Karina Ckless; Stephanie C Eisenbarth; Katherine A Fitzgerald; Richard A Flavell; Kathryn L Foley; Rebecca Martin; Benjamin T Suratt; Matthew E Poynter
Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):64-73.
2011: Bo Hu; Eran Elinav; Richard A Flavell
Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation.
Cell cycle (Georgetown, Tex.) 2011;10(12):1936-9.
2011: Eran Elinav; Till Strowig; Jorge Henao-Mejia; Richard A Flavell
Regulation of the antimicrobial response by NLR proteins.
Immunity 2011;34(5):665-79.
2011: Eran Elinav; Till Strowig; Andrew L Kau; Jorge Henao-Mejia; Christoph A Thaiss; Carmen J Booth; David R Peaper; John Bertin; Stephanie C Eisenbarth; Jeffrey I Gordon; Richard A Flavell
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.
Cell 2011;145(5):745-57.
2011: Masahito Kamanaka; Samuel Huber; Lauren A Zenewicz; Nicola Gagliani; Chozhavendan Rathinam; William O'Connor; Yisong Y Wan; Susumu Nakae; Yoichiro Iwakura; Liming Hao; Richard A Flavell
Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology.
The Journal of experimental medicine 2011;208(5):1027-40.
2011: Li Wen; Elizabeth A Green; Thomas Stratmann; Anaïs Panosa; Ramon Gomis; Elizabeth E Eynon; Richard A Flavell; Jovita A Mezquita; Conchi Mora
In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18.
European journal of immunology 2011;41(5):1344-51.
2011: Samuel Huber; Nicola Gagliani; Enric Esplugues; William O'Connor; Francis J Huber; Ashutosh Chaudhry; Masahito Kamanaka; Yasushi Kobayashi; Carmen J Booth; Alexander Y Rudensky; Maria Grazia Roncarolo; Manuela Battaglia; Richard A Flavell
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
Immunity 2011;34(4):554-65.
2011: Yanling Wu; Jianchao Xu; Heino Velazquez; Peili Wang; Guoyong Li; Dinggang Liu; Benedita Sampaio-Maia; Janete Quelhas-Santos; Kerry Russell; Raymond Russell; Richard A Flavell; Manuel Pestana; Frank Giordano; Gary V Desir
Renalase deficiency aggravates ischemic myocardial damage.
Kidney international 2011;79(8):853-60.
2011: Ilona Gutcher; Moses K Donkor; Qian Ma; Alexander Y Rudensky; Richard A Flavell; Ming O Li
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation.
Immunity 2011;34(3):396-408.
2011: Fabienne Andris; Sébastien Denanglaire; E Baus; Anthony Rongvaux; Jonathan Steuve; Richard A Flavell; Oberdan Leo
Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2245-53.
2011: Anthony Rongvaux; Tim Willinger; Hitoshi Takizawa; Chozhavendan Rathinam; Wojtek Auerbach; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Elizabeth Eynon; Sean Stevens; Markus G Manz; Richard A Flavell
Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2378-83.
2011: Tim Willinger; Anthony Rongvaux; Hitoshi Takizawa; George D Yancopoulos; David M Valenzuela; Andrew J Murphy; Wojtek Auerbach; Elizabeth Eynon; Sean Stevens; Markus G Manz; Richard A Flavell
Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2390-5.
2011: Jian Tao; Zhenzhou Wu; Liqing Zhao; Joe E Craft; Richard A Flavell; Jianlei Hao; Zhifang Hao; Zhangyong Hong; Xi Jiang; Masahito Kamanaka; Zhinan Yin
IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis.
Arthritis research & therapy 2011;13(6):R212.
2010: Bo Hu; Eran Elinav; Samuel Huber; Carmen J Booth; Till Strowig; Chengcheng Jin; Stephanie C Eisenbarth; Richard A Flavell
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21635-40.
2010: Yunqi Wang; Abdallah Souabni; Richard A Flavell; Yisong Y Wan
An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(10):5983-92.
2010: Jeongmin Song; Tim Willinger; Anthony Rongvaux; Elizabeth E Eynon; Sean Stevens; Markus G Manz; Richard A Flavell; Jorge E Galán
A mouse model for the human pathogen Salmonella typhi.
Cell host & microbe 2010;8(4):369-76.
2010: Chozhavendan Rathinam; Christine B F Thien; Richard A Flavell; Wallace Y Langdon
Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.
Cancer cell 2010;18(4):341-52.
2010: Martin Berglund; Silvia Melgar; Koichi S Kobayashi; Richard A Flavell; Elisabeth Hultgren Hörnquist; Olof H Hultgren
IL-1 receptor-associated kinase M downregulates DSS-induced colitis.
Inflammatory bowel diseases 2010;16(10):1778-86.
2010: Daniel Hawiger; Yisong Y Wan; Elizabeth E Eynon; Richard A Flavell
The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness.
Nature immunology 2010;11(10):962-8.
2010: Mariana S Frutuoso; Juliana I Hori; Marcelo S F Pereira; Djalma S L Junior; Fabiane Sônego; Koichi S Kobayashi; Richard A Flavell; Fernando Q Cunha; Dario S Zamboni
The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila.
Microbes and infection / Institut Pasteur 2010;12(11):819-27.
2010: Caroline Morel; Claire L Standen; Dae Young Jung; Susan Gray; Helena Ong; Richard A Flavell; Jason K Kim; Roger J Davis
Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance.
Molecular and cellular biology 2010;30(19):4616-25.
2010: Chengcheng Jin; Richard A Flavell
Molecular mechanism of NLRP3 inflammasome activation.
Journal of clinical immunology 2010;30(5):628-31.
2010: Samuel Huber; Richard A Flavell
Checks and balances: IL-23 in the intestine.
Immunity 2010;33(2):150-2.
2010: Richard A Flavell; Shomyseh Sanjabi; Stephen H Wrzesinski; Paula Licona-Limón
The polarization of immune cells in the tumour environment by TGFbeta.
Nature reviews. Immunology 2010;10(8):554-67.
2010: Weici Zhang; Masanobu Tsuda; Guo-Xiang Yang; Koichi tsuneyama; Guanghua Rong; William M Ridgway; Aftab A Ansari; Richard A Flavell; Ross Coppel; Zhe-Xiong Lian; M Eric Gershwin
Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis.
Hepatology (Baltimore, Md.) 2010;52(1):215-22.
2010: Chengcheng Jin; Richard A Flavell
Inflammasome activation. The missing link: how the inflammasome senses oxidative stress.
Immunology and cell biology 2010;88(5):510-2.
2010: William O'Connor; Lauren A Zenewicz; Richard A Flavell
The dual nature of T(H)17 cells: shifting the focus to function.
Nature immunology 2010;11(6):471-6.
2010: Leah L N Hubbard; Megan Noelle Ballinger; Peedikayil E Thomas; Carol A Wilke; Theodore J Standiford; Koichi S Kobayashi; Richard A Flavell; Bethany B Moore
A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6299-308.
2010: Kristina Archer; Florence Ader; Koichi S Kobayashi; Richard A Flavell; Craig R Roy
Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila.
Infection and immunity 2010;78(6):2477-87.
2010: Igor E Brodsky; Noah W Palm; Saheli Sadanand; Michelle B Ryndak; Fayyaz S Sutterwala; Richard A Flavell; James B Bliska; Ruslan Medzhitov
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system.
Cell host & microbe 2010;7(5):376-87.
2010: Eleni Ktistaki; Anna Garefalaki; Adam Williams; Simon R Andrews; Donald M Bell; Katie E Foster; Charalampos G Spilianakis; Richard A Flavell; Nadezda Kosyakova; Vladmir Trifonov; Thomas Liehr; Dimitris Kioussis
CD8 locus nuclear dynamics during thymocyte development.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5686-95.
2010: Chozhavendan Rathinam; Richard A Flavell
c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(18):8316-21.
2010: Adam Williams; Charalampos G Spilianakis; Richard A Flavell
Interchromosomal association and gene regulation in trans.
Trends in genetics : TIG 2010;26(4):188-97.
2010: Lauren A Zenewicz; Clara Abraham; Richard A Flavell; Judy H Cho
Unraveling the genetics of autoimmunity.
Cell 2010;140(6):791-7.
2010: Shomyseh Sanjabi; Richard A Flavell
Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling.
Journal of immunological methods 2010;353(1-2):111-4.
2010: Melissa A Kinnebrew; Carles Ubeda; Lauren A Zenewicz; Nichole Smith; Richard A Flavell; Eric G Pamer
Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection.
The Journal of infectious diseases 2010;201(4):534-43.
2010: Adam Williams; Richard A Flavell; Stephanie C Eisenbarth
The role of NOD-like Receptors in shaping adaptive immunity.
Current opinion in immunology 2010;22(1):34-40.
2010: Shomyseh Sanjabi; Richard A Flavell
Interaction between TGFbeta and the common gamma chain cytokines during an inflammatory immune response.
Cell cycle (Georgetown, Tex.) 2010;9(3):428-30.
2010: Grace K Silva; Fredy Gutierrez; Paulo Guedes; Catarina V Horta; Larissa D Cunha; Tiago W P Mineo; Juliana Santiago-Silva; Koichi S Kobayashi; Richard A Flavell; João S Silva; Dario S Zamboni
Cutting edge: nucleotide-binding oligomerization domain 1-dependent responses account for murine resistance against Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1148-52.
2010: Won-Woo Lee; Seong Wook Kang; Jihoon Choi; Seung-Hyun Lee; Kamini Shah; Elizabeth E Eynon; Richard A Flavell; Insoo Kang
Regulating human Th17 cells via differential expression of IL-1 receptor.
Blood 2010;115(3):530-40.
2010: Hongbo Chi; Richard A Flavell
Studies on MAP Kinase signaling in the immune system.
Methods in molecular biology (Clifton, N.J.) 2010;661():471-80.
2010: Anette Hübner; Julie Cavanagh-Kyros; Mercedes Rincon; Richard A Flavell; Roger J Davis
Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo.
Molecular and cellular biology 2010;30(1):98-105.
2009: Shankar S Iyer; Wilco P Pulskens; Jeffrey J Sadler; Loes M Butter; Gwendoline J Teske; Tyler K Ulland; Stephanie C Eisenbarth; Sandrine Florquin; Richard A Flavell; Jaklien C Leemans; Fayyaz S Sutterwala
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(48):20388-93.
2009: Mithilesh K Jha; Abdallah Badou; Marcel Meissner; John E McRory; Marc Freichel; Veit Flockerzi; Richard A Flavell
Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels.
Nature immunology 2009;10(12):1275-82.
2009: Feng Qian; Jing Deng; Ni Cheng; Emily J Welch; Yongliang Zhang; Asrar B Malik; Richard A Flavell; Chen Dong; Richard D Ye
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury.
The EMBO journal 2009;28(19):2896-907.
2009: Fengwei Bai; Terrence Town; Qian Feng; Penghua Wang; Masahito Kamanaka; Tarah M Connolly; David Gate; Ruth R Montgomery; Richard A Flavell; Erol Fikrig
IL-10 signaling blockade controls murine West Nile virus infection.
PLoS pathogens 2009;5(10):e1000610.
2009: Benjamin R Marks; Heba N Nowyhed; Jin-Young Choi; Amanda C Poholek; Jared M Odegard; Richard A Flavell; Joe Craft
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.
Nature immunology 2009;10(10):1125-32.
2009: Yisong Y Wan; Richard A Flavell
How diverse--CD4 effector T cells and their functions.
Journal of molecular cell biology 2009;1(1):20-36.
2009: Martin A Kriegel; Chozhavendan Rathinam; Richard A Flavell
E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16770-5.
2009: Xiaoyan Xiao; Peng Zhao; Daniel Rodriguez-Pinto; Dake Qi; Octavian Henegariu; Lena Alexopoulou; Richard A Flavell; F Susan Wong; Li Wen
Inflammatory regulation by TLR3 in acute hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3712-9.
2009: Didi Matza; Richard A Flavell
Roles of Ca(v) channels and AHNAK1 in T cells: the beauty and the beast.
Immunological reviews 2009;231(1):257-64.
2009: Claire L Standen; Norman J Kennedy; Richard A Flavell; Roger J Davis
Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
Molecular and cellular biology 2009;29(17):4831-40.
2009: Marina Tiemi Shio; Marina Tiemi Shio; Stephanie C Eisenbarth; Myriam Savaria; Adrien Vinet; Marie-Josée Bellemare; Kenneth W Harder; Fayyaz S Sutterwala; D Scott Bohle; Albert Descoteaux; Richard A Flavell; Martin Olivier
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.
PLoS pathogens 2009;5(8):e1000559.
2009: Vincent Bruno; Sebastian Hannemann; María Lara-Tejero; Richard A Flavell; Steven H Kleinstein; Jorge E Galán
Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells.
PLoS pathogens 2009;5(8):e1000538.
2009: Shomyseh Sanjabi; Lauren A Zenewicz; Masahito Kamanaka; Richard A Flavell
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.
Current opinion in pharmacology 2009;9(4):447-53.
2009: Shomyseh Sanjabi; Munir M Mosaheb; Richard A Flavell
Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.
Immunity 2009;31(1):131-44.
2009: Nelson C Di Paolo; Edward A Miao; Yoichiro Iwakura; Kaja Murali-Krishna; Alan Aderem; Richard A Flavell; Thalia Papayannopoulou; Dmitry M Shayakhmetov
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
Immunity 2009;31(1):110-21.
2009: Masahito Kamanaka; Dan Rainbow; Karin Schuster-Gossler; Elizabeth Eynon; Alexander V Chervonsky; Linda S Wicker; Richard A Flavell
Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11236-40.
2009: M Nedim Ince; David E Elliott; Tommy Setiawan; Ahmed Metwali; Arthur Blum; Hung-lin Chen; Joseph F Urban; Richard A Flavell; Joel V Weinstock
Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation.
European journal of immunology 2009;39(7):1870-8.
2009: Guangwei Liu; Samir Burns; Gonghua Huang; Kelli Boyd; Richard L Proia; Richard A Flavell; Hongbo Chi
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
Nature immunology 2009;10(7):769-77.
2009: Didi Matza; Abdallah Badou; Mithilesh K Jha; Tim Willinger; Andrey Antov; Shomyseh Sanjabi; Koichi S Kobayashi; Vincent T Marchesi; Richard A Flavell
Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9785-90.
2009: William O'Connor; Masahito Kamanaka; Carmen J Booth; Terrence Town; Susumu Nakae; Yoichiro Iwakura; Jay K Kolls; Richard A Flavell
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
Nature immunology 2009;10(6):603-9.
2009: Stacey L Demento; Stephanie C Eisenbarth; Harald G Foellmer; Craig Platt; Michael J Caplan; W Mark Saltzman; Ira Mellman; Michel Ledizet; Erol Fikrig; Richard A Flavell; Tarek M Fahmy
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy.
Vaccine 2009;27(23):3013-21.
2009: Chun Geun Lee; Dominik Hartl; Gap Ryol Lee; Barbara Koller; Hiroshi Matsuura; Carla A Da Silva; Myung Hyun Sohn; Lauren Cohn; Robert J Homer; Alexander A Kozhich; Alison A Humbles; Jennifer Kearley; Anthony J Coyle; Geoffrey L Chupp; Jennifer L Reed; Richard A Flavell; Jack A Elias
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.
The Journal of experimental medicine 2009;206(5):1149-66.
2009: Stephanie C Eisenbarth; Richard A Flavell
Innate instruction of adaptive immunity revisited: the inflammasome.
EMBO molecular medicine 2009;1(2):92-8.
2009: Lauren A Zenewicz; Andrey Antov; Richard A Flavell
CD4 T-cell differentiation and inflammatory bowel disease.
Trends in molecular medicine 2009;15(5):199-207.
2009: Robert E Cone; Subhasis Chattopadhyay; Roshanak Sharafieh; Yen Lemire; James O'Rourke; Richard A Flavell; Robert B Clark
T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber.
International immunology 2009;21(5):567-74.
2009: Dominik Hartl; Chuan Hua He; Babara Koller; Carla A Da Silva; Yasushi Kobayashi; Chun Geun Lee; Richard A Flavell; Jack A Elias
Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):5098-106.
2009: Erin R Steenblock; Stephen H Wrzesinski; Richard A Flavell; Tarek M Fahmy
Antigen presentation on artificial acellular substrates: modular systems for flexible, adaptable immunotherapy.
Expert opinion on biological therapy 2009;9(4):451-64.
2009: Jared M Odegard; Leah D DiPlacido; Lark Greenwald; Michael Kashgarian; Dwight H Kono; Chen Dong; Richard A Flavell; Joe Craft
ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4076-84.
2009: Holly L Rosenzweig; M M Jann; T T Glant; Tammy M Martin; Stephen R Planck; W van Eden; P J S van Kooten; Richard A Flavell; K S Kobayashi; James T Rosenbaum; Michael P Davey
Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis.
Journal of leukocyte biology 2009;85(4):711-8.
2009: Weiming Ouyang; Omar Beckett; Richard A Flavell; Ming O Li
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance.
Immunity 2009;30(3):358-71.
2009: Yuki Moritoki; Weici Zhang; Koichi tsuneyama; Katsunori Yoshida; Kanji Wakabayashi; Guo-Xiang Yang; Christopher L Bowlus; William M Ridgway; Yoshiyuki Ueno; Aftab A Ansari; Ross Coppel; Ian R Mackay; Richard A Flavell; M Eric Gershwin; Zhe-Xiong Lian
B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis.
Gastroenterology 2009;136(3):1037-47.
2009: Sandra S Diebold; Oliver Schulz; Lena Alexopoulou; W W Leitner; Richard A Flavell; Caetano Reis e Sousa
Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines.
Gene therapy 2009;16(3):359-66.
2009: Terrence Town; Fengwei Bai; Tian Wang; Amber Kaplan; Qian Feng; Ruth R Montgomery; John F Anderson; Richard A Flavell; Erol Fikrig
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing.
Immunity 2009;30(2):242-53.
2009: A K H Lim; David J Nikolic-Paterson; Frank Yuanfang Ma; Elyce Ozols; M C Thomas; Richard A Flavell; R J Davis; Gregory H Tesch
Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice.
Diabetologia 2009;52(2):347-58.
2009: Madhumita Das; Guadalupe Sabio; Feng Jiang; Mercedes Rincón; Richard A Flavell; Roger J Davis
Induction of hepatitis by JNK-mediated expression of TNF-alpha.
Cell 2009;136(2):249-60.
2009: Rebecca A Shilling; Bryan S Clay; Amanda G Tesciuba; Elizabeth L Berry; Tiffany Lu; Tamson V Moore; Hozefa S Bandukwala; Jiankun Tong; Joel V Weinstock; Richard A Flavell; Tom Horan; Steve K Yoshinaga; Andrew A Welcher; Judy L Cannon; Anne I Sperling
CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
Cellular immunology 2009;259(2):177-84.
2009: Peter M Rabinovich; Marina E Komarovskaya; Stephen H Wrzesinski; Jonathan L Alderman; Tulin Budak-Alpdogan; Alexander Karpikov; Hongfen Guo; Richard A Flavell; Nai-Kong V Cheung; Sherman M Weissman; Erkut Bahceci
Chimeric receptor mRNA transfection as a tool to generate antineoplastic lymphocytes.
Human gene therapy 2009;20(1):51-61.
2009: Kristina Archer; Lena Alexopoulou; Richard A Flavell; Craig R Roy
Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila.
Cellular microbiology 2009;11(1):21-36.
2008: Lynne Murray; Darryl A Knight; Laura McAlonan; Rochelle Argentieri; Amrita Joshi; Furquan Shaheen; Mark Cunningham; Lena Alexopolou; Richard A Flavell; Robert T Sarisky; Cory M Hogaboam
Deleterious role of TLR3 during hyperoxia-induced acute lung injury.
American journal of respiratory and critical care medicine 2008;178(12):1227-37.
2008: F Susan Wong; Changyun Hu; Li Zhang; Wei Du; Lena Alexopoulou; Richard A Flavell; Li Wen
The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice.
Annals of the New York Academy of Sciences 2008;1150():146-8.
2008: Lauren A Zenewicz; Richard A Flavell
IL-22 and inflammation: leukin' through a glass onion.
European journal of immunology 2008;38(12):3265-8.
2008: Jared M Odegard; Benjamin R Marks; Leah D DiPlacido; Amanda C Poholek; Dwight H Kono; Chen Dong; Richard A Flavell; Joe Craft
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.
The Journal of experimental medicine 2008;205(12):2873-86.
2008: Maziar Divangahi; Serge Mostowy; François Coulombe; Robert Kozak; loic Guillot; Frédéric Veyrier; Koichi S Kobayashi; Richard A Flavell; Philippe Gros; Marcel A Behr
NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7157-65.
2008: Tracey A Stephens; Enayat Nikoopour; Beverley Rider; Matilde Leon-Ponte; Thu A Chau; mikolajczak sebastian; Pratibha Chaturvedi; Edwin Lee-Chan; Richard A Flavell; S M Mansour Haeryfar; Joaquín Madrenas; Bhagirath Singh
Dendritic cell differentiation induced by a self-peptide derived from apolipoprotein E.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6859-71.
2008: C Watanabe; Geraldine L Shu; Timothy S Zheng; Richard A Flavell; Edward A Clark
Caspase 6 regulates B cell activation and differentiation into plasma cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6810-9.
2008: Sunny Shin; Christopher L Case; Kristina Archer; Catarina V Nogueira; Koichi S Kobayashi; Richard A Flavell; Craig R Roy; Dario S Zamboni
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila.
PLoS pathogens 2008;4(11):e1000220.
2008: Chozhavendan Rathinam; Richard A Flavell
The hematopoiesis paradigm: clarity or ambiguity?
Blood 2008;112(9):3534-5.
2008: Yisong Y Wan; Richard A Flavell
TGF-beta and regulatory T cell in immunity and autoimmunity.
Journal of clinical immunology 2008;28(6):647-59.
2008: Maile R Brown; Jack Kronengold; Valeswara-Rao Gazula; Charalampos Spilianakis; Richard A Flavell; Christian A A von Hehn; Arin Bhattacharjee; Leonard K Kaczmarek
Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.
The Journal of physiology 2008;586(Pt 21):5161-79.
2008: Christophe M Filippi; Amy E Juedes; Janine E Oldham; Ellie Ling; Lisa Togher; Yufeng Peng; Richard A Flavell; Matthias G von Herrath
Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity.
Diabetes 2008;57(10):2684-92.
2008: Joshua J Breunig; Matthew Sarkisian; Jon I Arellano; Yury M Morozov; Albert E Ayoub; Sonal Sojitra; Baolin Wang; Richard A Flavell; Pasko Rakic; Terrence Town
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):13127-32.
2008: Jan Czyzyk; Hui-Chen Chen; Kim Bottomly; Richard A Flavell
p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells.
The Journal of biological chemistry 2008;283(34):23004-15.
2008: Ming O Li; Richard A Flavell
TGF-beta: a master of all T cell trades.
Cell 2008;134(3):392-404.
2008: Yasmina Laouar; Terrence Town; David Jeng; Elise Tran; Yisong Y Wan; Vijay K Kuchroo; Richard A Flavell
TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10865-70.
2008: Shuhui Wang; Thomas Welte; Maureen McGargill; Terrence Town; Jesse Thompson; John F Anderson; Richard A Flavell; Erol Fikrig; Stephen M Hedrick; Tian Wang
Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2084-91.
2008: Holly L Rosenzweig; Tammy M Martin; Stephen R Planck; K Galster; M M Jann; Michael P Davey; K Kobayashi; Richard A Flavell; James T Rosenbaum
Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling.
Journal of leukocyte biology 2008;84(2):529-36.
2008: Suzanne L Cassel; Stephanie C Eisenbarth; Shankar S Iyer; Jeffrey J Sadler; Oscar R Colegio; Linda Tephly; A Brent Carter; Paul B Rothman; Richard A Flavell; Fayyaz S Sutterwala
The Nalp3 inflammasome is essential for the development of silicosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9035-40.
2008: S V Kim; Richard A Flavell
Myosin I: from yeast to human.
Cellular and molecular life sciences : CMLS 2008;65(14):2128-37.
2008: Stephanie C Eisenbarth; Oscar R Colegio; William O'Connor; Fayyaz S Sutterwala; Richard A Flavell
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.
Nature 2008;453(7198):1122-6.
2008: Suzanne L Cassel; Fayyaz S Sutterwala; Richard A Flavell
The tiny conductor: immune regulation via commensal organisms.
Cell host & microbe 2008;3(6):340-1.
2008: Jun Fujita; Ana Crane; Marlon K Souza; Marion Dejosez; Michael Kyba; Richard A Flavell; James A Thomson; Thomas P Zwaka
Caspase activity mediates the differentiation of embryonic stem cells.
Cell stem cell 2008;2(6):595-601.
2008: Terrence Town; Yasmina Laouar; Christopher Pittenger; Takashi Mori; Christine A Szekely; Jun Tan; Ronald S Duman; Richard A Flavell
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
Nature medicine 2008;14(6):681-7.
2008: Marie-Edith Lafon; Françoise Mégret; Sven G Meuth; Ole Simon; Myriam L Velandia Romero; Mireille Lafage; Lieping Chen; Lena Alexopoulou; Richard A Flavell; Christophe Prehaud; Heinz Wiendl
Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7506-15.
2008: Anurag Singh; William F Carson; Eric R Secor; Linda A Guernsey; Richard A Flavell; Robert B Clark; Roger S Thrall; Craig M Schramm
Regulatory role of B cells in a murine model of allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7318-26.
2008: Guo-Xiang Yang; Zhe-Xiong Lian; Ya-Hui Chuang; Yuki Moritoki; Ruth Y Lan; Kanji Wakabayashi; Aftab A Ansari; Richard A Flavell; William M Ridgway; Ross Coppel; Koichi tsuneyama; Ian R Mackay; M Eric Gershwin
Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice.
Hepatology (Baltimore, Md.) 2008;47(6):1974-82.
2008: Anette Hübner; Tamera Barrett; Richard A Flavell; Roger J Davis
Multisite phosphorylation regulates Bim stability and apoptotic activity.
Molecular cell 2008;30(4):415-25.
2008: Bhanu P Pappu; Anna Borodovsky; Timothy S Zheng; Xuexian Yang; Ping Wu; Xingwen Dong; Shawn Weng; Beth Browning; Martin L Scott; Li Ma; Lihe Su; Qiang Tian; Pascal Schneider; Richard A Flavell; Chen Dong; Linda C Burkly
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease.
The Journal of experimental medicine 2008;205(5):1049-62.
2008: Sebastien Jacquet; Yasuhiro Nishino; Sarawut Kumphune; Pierre Sicard; James E Clark; Koichi Kobayashi; Richard A Flavell; Jan Eickhoff; Matt Cotten; Michael S Marber
The role of RIP2 in p38 MAPK activation in the stressed heart.
The Journal of biological chemistry 2008;283(18):11964-71.
2008: Timothy M Fan; David M Kranz; Richard A Flavell; Edward J Roy
Costimulatory strength influences the differential effects of transforming growth factor beta1 for the generation of CD8+ regulatory T cells.
Molecular immunology 2008;45(10):2937-50.
2008: Núria Reig; Aimin Jiang; Rachael Couture; Fayyaz S Sutterwala; Yasunori Ogura; Richard A Flavell; Ira Mellman; F Gisou van der Goot
Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin.
Cellular microbiology 2008;10(5):1190-207.
2008: Chozhavendan Rathinam; Christine B F Thien; Wallace Y Langdon; Hua Gu; Richard A Flavell
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.
Genes & development 2008;22(8):992-7.
2008: Adam Williams; Richard A Flavell
The role of CTCF in regulating nuclear organization.
The Journal of experimental medicine 2008;205(4):747-50.
2008: Ming O Li; Richard A Flavell
Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10.
Immunity 2008;28(4):468-76.
2008: Holly L Rosenzweig; Tammy M Martin; Monica M Jann; Stephen R Planck; Michael P Davey; Koichi Kobayashi; Richard A Flavell; James T Rosenbaum
NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis.
Investigative ophthalmology & visual science 2008;49(4):1518-24.
2008: Subhasis Mohanty; Terrence Town; Tomohito Yagi; Christina Scheidig; Kelvin Y Kwan; Heather G Allore; Richard A Flavell; Tomohito Yagi
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5063-8.
2008: Jose M Rojo; Eliana Pini; Gloria Ojeda; Raquel Bello; Chen Dong; Richard A Flavell; Umberto Dianzani; Pilar Portolés
CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'.
International immunology 2008;20(4):577-89.
2008: Kyoichi Fukuda; Gregory H Tesch; Felicia Y Yap; Josephine M Forbes; Richard A Flavell; Roger J Davis; David J Nikolic-Paterson
MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model.
Laboratory investigation; a journal of technical methods and pathology 2008;88(4):398-407.
2008: Silvia S Kang; Seth M Bloom; Lyse A Norian; Michael J Geske; Richard A Flavell; Thaddeus S Stappenbeck; Paul M Allen
An antibiotic-responsive mouse model of fulminant ulcerative colitis.
PLoS medicine 2008;5(3):e41.
2008: Jenny P-Y Ting; Ruth C Lovering; Emad S Alnemri; John Bertin; Jeremy M Boss; Beckley K Davis; Richard A Flavell; Stephen E Girardin; Adam Godzik; Jonathan A Harton; Hal M Hoffman; Jean-Pierre Hugot; Naohiro Inohara; Alex Mackenzie; Lois J Maltais; Gabriel Nunez; Yasunori Ogura; Luc A Otten; Dana Philpott; John C Reed; Walter Reith; Stefan Schreiber; Viktor Steimle; Peter A Ward
The NLR gene family: a standard nomenclature.
Immunity 2008;28(3):285-7.
2008: Daniel Hawiger; Elise Tran; Wei Du; Carmen J Booth; Li Wen; Chen Dong; Richard A Flavell
ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3140-7.
2008: Rong Ou; Menghua Zhang; Lei Huang; Richard A Flavell; Pandelakis Koni; Dimitrios Moskofidis
Regulation of immune response and inflammatory reactions against viral infection by VCAM-1.
Journal of virology 2008;82(6):2952-65.
2008: Terrence Town; Joshua J Breunig; Matthew Sarkisian; Charalampos Spilianakis; Albert E Ayoub; Xiuxin Liu; Anthony F Ferrandino; Anna Rachel Gallagher; Ming O Li; Pasko Rakic; Richard A Flavell
The stumpy gene is required for mammalian ciliogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2853-8.
2008: Kevin N Couper; Daniel G Blount; Mark S Wilson; Julius Hafalla; Yasmine Belkaid; Masahito Kamanaka; Richard A Flavell; J Brian de Souza; Eleanor M Riley
IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.
PLoS pathogens 2008;4(2):e1000004.
2008: Ya-Hui Chuang; Zhe-Xiong Lian; Guo-Xiang Yang; Shang-an Shu; Yuki Moritoki; William M Ridgway; Aftab A Ansari; Mitchell Kronenberg; Richard A Flavell; Bin Gao; M Eric Gershwin
Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2008;47(2):571-80.
2008: Fayyaz S Sutterwala; Richard A Flavell
Immunology: cascade into clarity.
Nature 2008;451(7176):254-5.
2008: Hongbo Chi; Richard A Flavell
Acetylation of MKP-1 and the control of inflammation.
Science signaling 2008;1(41):pe44.
2008: Hongbo Chi; Richard A Flavell
Innate recognition of non-self nucleic acids.
Genome biology 2008;9(3):211.
2008: Didi Matza; Abdallah Badou; Koichi Kobayashi; Karen Goldsmith-Pestana; Yutaka Masuda; Akihiko Komuro; Diane McMahon-Pratt; Vincent T Marchesi; Richard A Flavell
A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation.
Immunity 2008;28(1):64-74.
2008: Håkan T L Hall; Margareta T Wilhelm; Samuel D Saibil; Tak W Mak; Richard A Flavell; Pamela S Ohashi
RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses.
European journal of immunology 2008;38(1):64-72.
2008: Joao H F Pedra; Jochen Mattner; Jian Tao; Steven M Kerfoot; Roger J Davis; Richard A Flavell; Philip W Askenase; Zhinan Yin; Erol Fikrig
c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.
Infection and immunity 2008;76(1):308-16.
2007: Fayyaz S Sutterwala; Lilia Mijares; Li Li; Yasunori Ogura; Barbara I Kazmierczak; Richard A Flavell
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.
The Journal of experimental medicine 2007;204(13):3235-45.
2007: Amit Awasthi; Yijun Carrier; Jean P S Peron; Estelle Bettelli; Masahito Kamanaka; Richard A Flavell; Vijay K Kuchroo; Mohamed Oukka; Howard L Weiner
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.
Nature immunology 2007;8(12):1380-9.
2007: Yisong Y Wan; Richard A Flavell
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation.
Immunological reviews 2007;220():199-213.
2007: Jonathan Deane; Prapaporn Pisitkun; Rebecca S Barrett; Lionel Feigenbaum; Terrence Town; Jerrold M Ward; Richard A Flavell; Silvia Bolland
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation.
Immunity 2007;27(5):801-10.
2007: Ian J Thomas; Liliana G Petrich de Marquesini; Rommel Ravanan; Richard M Smith; Sylvie Guerder; Richard A Flavell; David C Wraith; Li Wen; F Susan Wong
CD86 has sustained costimulatory effects on CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5936-46.
2007: Suchithra Menon; Hongbo Chi; Huiyong Zhang; Xing Wang Deng; Richard A Flavell; Ning Wei
COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
Nature immunology 2007;8(11):1236-45.
2007: Frank Yuanfang Ma; Gregory H Tesch; Richard A Flavell; Roger J Davis; David J Nikolic-Paterson
MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney.
American journal of physiology. Renal physiology 2007;293(5):F1556-63.
2007: Daniel H Kaplan; Ming O Li; Matthew C Jenison; Warren D Shlomchik; Richard A Flavell; Mark J Shlomchik
Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells.
The Journal of experimental medicine 2007;204(11):2545-52.
2007: Sean T Kim; Patrick E Fields; Richard A Flavell
Demethylation of a specific hypersensitive site in the Th2 locus control region.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17052-7.
2007: Madhumita Das; Feng Jiang; Hayla K Sluss; Chao Zhang; Kevan M Shokat; Richard A Flavell; Roger J Davis
Suppression of p53-dependent senescence by the JNK signal transduction pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15759-64.
2007: Lauren A Zenewicz; George D Yancopoulos; David M Valenzuela; Andrew J Murphy; Margaret L Karow; Richard A Flavell
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.
Immunity 2007;27(4):647-59.
2007: Mark Wilson; Eldad Elnekave; Margaret M Mentink-Kane; Marcus G Hodges; John Pesce; Thirumalai Ramalingam; Robert W Thompson; Masahito Kamanaka; Richard A Flavell; Andrea Keane-Myers; Allen W Cheever; Thomas A Wynn
IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice.
The Journal of clinical investigation 2007;117(10):2941-51.
2007: Joao H F Pedra; Fayyaz S Sutterwala; Bindu Sukumaran; Yasunori Ogura; Qian Feng; Ruth R Montgomery; Richard A Flavell; Erol Fikrig
ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4783-91.
2007: Akira Moh; Yoshiki Iwamoto; Gui-Xuan Chai; Samual Shao-Min Zhang; Arihiro Kano; Derek D Yang; Wenjun Zhang; Jun Wang; Joerg J Jacoby; Bin Gao; Richard A Flavell; Xin-Yuan Fu
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery.
Laboratory investigation; a journal of technical methods and pathology 2007;87(10):1018-28.
2007: Stephen H Wrzesinski; Yisong Y Wan; Richard A Flavell
Transforming growth factor-beta and the immune response: implications for anticancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 1):5262-70.
2007: Norman J Kennedy; Gilles Martin; Anka G Ehrhardt; Julie Cavanagh-Kyros; Chia-Yi Kuan; Pasko Rakic; Richard A Flavell; Steven N Treistman; Roger J Davis
Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.
Genes & development 2007;21(18):2336-46.
2007: Stephen B Willingham; Daniel T Bergstralh; William O'Connor; Amy C Morrison; Debra J Taxman; Joseph A Duncan; Shoshana BarNoy; Malabi M Venkatesan; Richard A Flavell; Mohanish Deshmukh; Hal M Hoffman; Jenny P-Y Ting
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.
Cell host & microbe 2007;2(3):147-59.
2007: Jae Hyang Lim; Brigid Stirling; Jonathan Derry; Tomoaki Koga; Hirofumi Jono; Chang-Hoon Woo; Haodong Xu; Patricia Bourne; Un-Hwan Ha; Hajime Ishinaga; Haidong Xu; Ali Andalibi; Xin-Hua Feng; Hongguang Zhu; Yuxian Huang; Wenhong Zhang; Xinhua Weng; Chen Yan; Zhinan Yin; David E Briles; Roger J Davis; Richard A Flavell; Jian-Dong Li
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.
Immunity 2007;27(2):349-60.
2007: Joao H F Pedra; Jian Tao; Fayyaz S Sutterwala; Bindu Sukumaran; Nancy Berliner; Linda K Bockenstedt; Richard A Flavell; Zhinan Yin; Erol Fikrig
IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis.
FEMS immunology and medical microbiology 2007;50(3):401-10.
2007: Fayyaz S Sutterwala; Yasunori Ogura; Richard A Flavell
The inflammasome in pathogen recognition and inflammation.
Journal of leukocyte biology 2007;82(2):259-64.
2007: Hongbo Chi; Richard A Flavell
Immunology: sensing the enemy within.
Nature 2007;448(7152):423-4.
2007: Derk Amsen; Andrey Antov; Dragana Jankovic; Alan Sher; Freddy Radtke; Abdallah Souabni; Meinrad Busslinger; Brent McCright; Thomas Gridley; Richard A Flavell
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
Immunity 2007;27(1):89-99.
2007: Yisong Y Wan; Richard A Flavell
Regulatory T cells, transforming growth factor-beta, and immune suppression.
Proceedings of the American Thoracic Society 2007;4(3):271-6.
2007: Chang Tong; Zhinan Yin; Zibo Song; Ashley Dockendorff; Chuanshu Huang; John M Mariadason; Richard A Flavell; Roger J Davis; Leonard H Augenlicht; Wancai Yang
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression.
The American journal of pathology 2007;171(1):297-303.
2007: Charalampos Spilianakis; Richard A Flavell
Epigenetic regulation of Ifng expression.
Nature immunology 2007;8(7):681-3.
2007: Qilin Pan; John C Mathison; Colleen Fearns; Vladimir V Kravchenko; Jean da Silva Correia; Hal M Hoffman; Koichi Kobayashi; John Bertin; Ethan P Grant; Anthony J Coyle; Fayyaz S Sutterwala; Yasunori Ogura; Richard A Flavell; Richard J Ulevitch
MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.
Journal of leukocyte biology 2007;82(1):177-83.
2007: Neil C Henderson; Katharine J Pollock; John Frew; Alison C Mackinnon; Richard A Flavell; Roger J Davis; Tariq Sethi; Kenneth J Simpson
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
Gut 2007;56(7):982-90.
2007: James E Clark; Richard A Flavell; Matthew E Faircloth; Roger J Davis; Richard J Heads; Michael S Marber
Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3).
Cardiovascular research 2007;74(3):466-70.
2007: Ali Masud; Alexander Mohapatra; Saquib A Lakhani; Anthony Ferrandino; Raza Hakem; Richard A Flavell
Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.
The Journal of biological chemistry 2007;282(19):14132-9.
2007: Ming O Li; Yisong Y Wan; Richard A Flavell
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.
Immunity 2007;26(5):579-91.
2007: Grisha Pirianov; Katarina G Brywe; Carina Mallard; A David Edwards; Richard A Flavell; Henrik Hagberg; Huseyin Mehmet
Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(5):1022-32.
2007: Brian B Gowen; Min-Hui Wong; Kie-Hoon Jung; Andrew B Sanders; William M Mitchell; Lena Alexopoulou; Richard A Flavell; Robert W Sidwell
TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5200-8.
2007: Yasushi Takai; Tiina Matikainen; Andrea Jurisicova; Mee-Ran Kim; Alexander M Trbovich; E Fujita; T Nakagawa; Bénédicte Lemmers; Richard A Flavell; Raza Hakem; T Momoi; J Yuan; Jonathan L Tilly; Gloria I Perez
Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells.
Apoptosis : an international journal on programmed cell death 2007;12(4):791-800.
2007: Liang Chen; Weifeng He; Sean T Kim; Jian Tao; Yunfei Gao; Hongbo Chi; Andrew M Intlekofer; Bohdan Harvey; Steven L Reiner; Zhinan Yin; Richard A Flavell; Joe Craft
Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2730-6.
2007: Jian Tao; Yunfei Gao; Ming O Li; Weifeng He; Liang Chen; Bohdan Harvev; Roger J Davis; Richard A Flavell; Zhinan Yin
JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.
European journal of immunology 2007;37(3):818-29.
2007: Dragana Jankovic; Marika C Kullberg; Carl G Feng; Romina S Goldszmid; Carmen M Collazo; Mark Wilson; Thomas A Wynn; Masahito Kamanaka; Richard A Flavell; Alan Sher
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.
The Journal of experimental medicine 2007;204(2):273-83.
2007: Yisong Y Wan; Richard A Flavell
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression.
Nature 2007;445(7129):766-70.
2007: Fengwei Bai; Terrence Town; Deepti Pradhan; Jonathan Cox; Michel Ledizet; John F Anderson; Richard A Flavell; Joanna K Krueger; Raymond A Koski; Erol Fikrig
Antiviral peptides targeting the west nile virus envelope protein.
Journal of virology 2007;81(4):2047-55.
2007: Joslyn K Brunelle; Emelyn H Shroff; Harris Perlman; Andreas Strasser; Carlos T Moraes; Richard A Flavell; Nika N Danial; Brian Keith; Craig Thompson; Navdeep S Chandel
Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death.
Molecular and cellular biology 2007;27(4):1222-35.
2007: Pietro Fazzari; Junia Penachioni; Sara Gianola; Ferdinando Rossi; Britta J Eickholt; Flavio Maina; Lena Alexopoulou; Antonino Sottile; paolo comoglio; Richard A Flavell; Luca Tamagnone
Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis.
BMC developmental biology 2007;7():55.
2007: Ulla-Angela Temann; Yasmina Laouar; Elizabeth E Eynon; Robert J Homer; Richard A Flavell
IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells.
International immunology 2007;19(1):1-10.
2007: Hordur S Hardarson; J Scott Baker; Zhao Yang; Enkhsaikhan Purevjav; Chien-Hua Huang; Lena Alexopoulou; Na Li; Richard A Flavell; Neil E Bowles; Jesus G Vallejo
Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury.
American journal of physiology. Heart and circulatory physiology 2007;292(1):H251-8.
2006: Mahasweta Girgenrath; Shawn Weng; Christine A Kostek; Beth Browning; Monica Wang; Sharron A N Brown; Jeffrey A Winkles; Jennifer S Michaelson; Normand E Allaire; Pascal Schneider; Martin L Scott; Yen-Ming Hsu; Hideo Yagita; Richard A Flavell; Jeffrey Boone Miller; Linda C Burkly; Timothy S Zheng
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration.
The EMBO journal 2006;25(24):5826-39.
2006: Matthew Sarkisian; Christopher M Bartley; Hongbo Chi; Fumihiko Nakamura; Kazue Hashimoto-Torii; Masaaki Torii; Richard A Flavell; Pasko Rakic
MEKK4 signaling regulates filamin expression and neuronal migration.
Neuron 2006;52(5):789-801.
2006: Phoebe Luo; B D Reed; Tom C Tsang; David T Harris; Richard A Flavell
A self-augmenting gene expression cassette for enhanced and sustained transgene expression in the presence of proinflammatory cytokines.
DNA and cell biology 2006;25(12):659-67.
2006: Masahito Kamanaka; Sean T Kim; Yisong Y Wan; Fayyaz S Sutterwala; María Lara-Tejero; Jorge E Galán; Edward W Harhaj; Richard A Flavell
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse.
Immunity 2006;25(6):941-52.
2006: Brian B Gowen; Justin D Hoopes; Min-Hui Wong; Kie-Hoon Jung; Kevin C Isakson; Lena Alexopoulou; Richard A Flavell; Robert W Sidwell
TLR3 deletion limits mortality and disease severity due to Phlebovirus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6301-7.
2006: Marc Veldhoen; Richard J Hocking; Richard A Flavell; Brigitta Stockinger
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.
Nature immunology 2006;7(11):1151-6.
2006: Ruibo Wang; Terrence Town; Varun Gokarn; Richard A Flavell; Rajiv Y Chandawarkar
HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways.
The Journal of surgical research 2006;136(1):58-69.
2006: Abdallah Badou; Mithilesh Kumar Jha; Didi Matza; Wajahat Z Mehal; Marc Freichel; Veit Flockerzi; Richard A Flavell
Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15529-34.
2006: Sangwon V Kim; Wajahat Z Mehal; Xuemei Dong; Volkmar Heinrich; Marc Pypaert; Ira Mellman; micah dembo; Mark S Mooseker; Dianqing Wu; Richard A Flavell
Modulation of cell adhesion and motility in the immune system by Myo1f.
Science (New York, N.Y.) 2006;314(5796):136-9.
2006: Anja Jaeschke; Maria Karasarides; Juan-Jose Ventura; Anka Ehrhardt; Chao Zhang; Richard A Flavell; Kevan M Shokat; Roger J Davis
JNK2 is a positive regulator of the cJun transcription factor.
Molecular cell 2006;23(6):899-911.
2006: Elise H Tran; Yasu-Taka Azuma; Manchuan Chen; Claire Weston; Roger J Davis; Richard A Flavell
Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(36):13451-6.
2006: Sean R Christensen; Jonathan Shupe; Kevin Nickerson; Michael Kashgarian; Richard A Flavell; Mark J Shlomchik
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.
Immunity 2006;25(3):417-28.
2006: Ming O Li; Shomyseh Sanjabi; Richard A Flavell
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms.
Immunity 2006;25(3):455-71.
2006: Jane C Deng; Genhong Cheng; Michael W Newstead; Xianying Zeng; Koichi Kobayashi; Richard A Flavell; Theodore J Standiford
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M.
The Journal of clinical investigation 2006;116(9):2532-42.
2006: J Pablo Abonia; Jenny Hallgren; Tatiana Jones; Tong Shi; Yuhui Xu; Pandelakis Koni; Richard A Flavell; Joshua A Boyce; K Frank Austen; Tatiana G Jones
Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung.
Blood 2006;108(5):1588-94.
2006: Yasunori Ogura; Fayyaz S Sutterwala; Richard A Flavell
The inflammasome: first line of the immune response to cell stress.
Cell 2006;126(4):659-62.
2006: Vincent Feuillet; Samir Medjane; Isabelle Mondor; Olivier Demaria; Philippe Pagni; Jorge E Galán; Richard A Flavell; Lena Alexopoulou
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12487-92.
2006: Yisong Y Wan; Richard A Flavell
The roles for cytokines in the generation and maintenance of regulatory T cells.
Immunological reviews 2006;212():114-30.
2006: Mohamed Bellahcene; Sebastien Jacquet; Xue B Cao; Masaya Tanno; Robert S Haworth; Joanne Layland; Alamgir M N Kabir; Matthias Gaestel; Roger J Davis; Richard A Flavell; Ajay M Shah; Metin Avkiran; Michael S Marber
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor.
Journal of the American College of Cardiology 2006;48(3):545-55.
2006: Sabine Oertelt; Zhe-Xiong Lian; Chun-Mei Cheng; Ya-Hui Chuang; Kerstien A Padgett; Xiaosong He; William M Ridgway; Aftab A Ansari; Ross Coppel; Ming O Li; Richard A Flavell; Mitchell Kronenberg; Ian R Mackay; M Eric Gershwin
Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1655-60.
2006: Yisong Y Wan; Hongbo Chi; Min Xie; Michael D Schneider; Richard A Flavell
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function.
Nature immunology 2006;7(8):851-8.
2006: María Lara-Tejero; Fayyaz S Sutterwala; Yasunori Ogura; Ethan P Grant; John Bertin; Anthony J Coyle; Richard A Flavell; Jorge E Galán
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.
The Journal of experimental medicine 2006;203(6):1407-12.
2006: Leonid Gitlin; Winfried Barchet; Susan Gilfillan; Marina Cella; Bruce Beutler; Richard A Flavell; Michael S Diamond; Marco COLONna
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8459-64.
2006: Beth Doran; Norberto Gherbesi; Gregory M Hendricks; Richard A Flavell; Roger J Davis; Laxman Dass Gangwani
Deficiency of the zinc finger protein ZPR1 causes neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7471-5.
2006: Wei Du; F Susan Wong; Ming O Li; Jian Peng; Hao Qi; Richard A Flavell; Robert S Sherwin; Li Wen
TGF-beta signaling is required for the function of insulin-reactive T regulatory cells.
The Journal of clinical investigation 2006;116(5):1360-70.
2006: Bing Ma; Michael R Blackburn; Chun Geun Lee; Robert J Homer; Wei Liu; Richard A Flavell; Lynn Boyden; Richard P Lifton; Chun-Xiao Sun; Hays W J Young; Jack A Elias
Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis.
The Journal of clinical investigation 2006;116(5):1274-83.
2006: Wenfang Wu; Ravi S Misra; Jennifer Q Russell; Richard A Flavell; Mercedes Rincón; Ralph C Budd
Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3.
The Journal of biological chemistry 2006;281(16):10682-90.
2006: Charalampos Spilianakis; Richard A Flavell
Molecular biology. Managing associations between different chromosomes.
Science (New York, N.Y.) 2006;312(5771):207-8.
2006: Tomoyuki Inoue; David L Boyle; Maripat Corr; Deepa Hammaker; Roger J Davis; Richard A Flavell; Gary S Firestein
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5484-9.
2006: Gap Ryol Lee; Sean T Kim; Charalampos Spilianakis; Patrick E Fields; Richard A Flavell
T helper cell differentiation: regulation by cis elements and epigenetics.
Immunity 2006;24(4):369-79.
2006: Martin A Kriegel; Ming O Li; Shomyseh Sanjabi; Yisong Y Wan; Richard A Flavell
Transforming growth factor-beta: recent advances on its role in immune tolerance.
Current rheumatology reports 2006;8(2):138-44.
2006: Qilin Pan; Vladimir V Kravchenko; Alex Katz; Shuang Huang; Masayuki Ii; John C Mathison; Koichi Kobayashi; Richard A Flavell; Robert D Schreiber; David V Goeddel; Richard J Ulevitch
NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway.
Infection and immunity 2006;74(4):2121-7.
2006: Terrence Town; David Jeng; Lena Alexopoulou; Jun Tan; Richard A Flavell
Microglia recognize double-stranded RNA via TLR3.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3804-12.
2006: Juan-Jose Ventura; Anette Hübner; Chao Zhang; Richard A Flavell; Kevan M Shokat; Roger J Davis
Chemical genetic analysis of the time course of signal transduction by JNK.
Molecular cell 2006;21(5):701-10.
2006: Justin E Mitchell; Marija Cvetanovic; Nitu Tibrewal; Vimal A Patel; Oscar R Colamonici; Ming O Li; Richard A Flavell; Jerrold S Levine; Raymond B Birge; David S Ucker
The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells.
The Journal of biological chemistry 2006;281(9):5718-25.
2006: Ming O Li; Richard A Flavell
TGF-beta, T-cell tolerance and immunotherapy of autoimmune diseases and cancer.
Expert review of clinical immunology 2006;2(2):257-65.
2006: Fayyaz S Sutterwala; Yasunori Ogura; Marian Szczepanik; María Lara-Tejero; G Scott Lichtenberger; Ethan P Grant; John Bertin; Anthony J Coyle; Jorge E Galán; Philip W Askenase; Richard A Flavell
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.
Immunity 2006;24(3):317-27.
2006: Dario S Zamboni; Koichi Kobayashi; Tiana Kohlsdorf; Yasunori Ogura; E Michelle Long; Russell E Vance; Keisuke Kuida; Sanjeev Mariathasan; Xiaodong Huang; Richard A Flavell; William F Dietrich; Craig R Roy
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.
Nature immunology 2006;7(3):318-25.
2006: Hongbo Chi; Sean P Barry; Rachel J Roth; J Julie Wu; Elizabeth A Jones; Anton M Bennett; Richard A Flavell
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2274-9.
2006: Saquib A Lakhani; Ali Masud; Keisuke Kuida; George A Porter; Carmen J Booth; Wajahat Z Mehal; Irteza Bin Inayat; Richard A Flavell
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.
Science (New York, N.Y.) 2006;311(5762):847-51.
2006: Hafid Ait-Oufella; Benoît L Salomon; Stephane Potteaux; Anna-Karin L Robertson; Pierre Gourdy; Joffrey Zoll; Régine Merval; Bruno Esposito; José L Cohen; Sylvain Fisson; Richard A Flavell; Göran K Hansson; David Klatzmann; Alain Tedgui; Ziad Mallat
Natural regulatory T cells control the development of atherosclerosis in mice.
Nature medicine 2006;12(2):178-80.
2006: Brian D Rudd; Joost J Smit; Richard A Flavell; Lena Alexopoulou; Matthew A Schaller; Achim Gruber; Aaron A Berlin; Nicholas W Lukacs
Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1937-42.
2006: Elizabeth A Wohlfert; Leonid Gorelik; Robert S Mittler; Richard A Flavell; Robert B Clark
Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1316-20.
2006: Isabelle Millet; F Susan Wong; Werner Gurr; Li Wen; Walter S Zawalich; E Allison Green; Richard A Flavell; Robert S Sherwin
Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes.
Journal of autoimmunity 2006;26(1):7-15.
2006: Fayyaz S Sutterwala; Yasunori Ogura; Dario S Zamboni; Craig R Roy; Richard A Flavell
NALP3: a key player in caspase-1 activation.
Journal of endotoxin research 2006;12(4):251-6.
2006: Eva Matalova; Paul T Sharpe; Saquib A Lakhani; Kevin A Roth; Richard A Flavell; Jana Setkova; Ivan Misek; Abigail S Tucker
Molar tooth development in caspase-3 deficient mice.
The International journal of developmental biology 2006;50(5):491-7.
2006: Ming O Li; Yisong Y Wan; Shomyseh Sanjabi; Anna-Karin L Robertson; Richard A Flavell
Transforming growth factor-beta regulation of immune responses.
Annual review of immunology 2006;24():99-146.
2006: Basel K al-Ramadi; Maria J Fernandez-Cabezudo; Azim Ullah; Hussain EL HASASNA; Richard A Flavell
CD154 is essential for protective immunity in experimental salmonella infection: evidence for a dual role in innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):496-506.
2006: Y Peng; Leonid Gorelik; Yasmina Laouar; Ming O Li; Richard A Flavell
TGFbeta-mediated immunoregulation.
Ernst Schering Research Foundation workshop 2006;(56):155-60.
2005: Richard A Flavell; Leonard K Kaczmarek; Abdallah Badou; Emile L Boulpaep; Rooma Desai; Srisaila Basavappa; Didi Matza; You-Qing Peng; Wajahat Z Mehal
Retraction.
Science (New York, N.Y.) 2005;310(5756):1903.
2005: Charalampos Spilianakis; Gap Ryol Lee; Richard A Flavell
Twisting the Th1/Th2 immune response via the retinoid X receptor: lessons from a genetic approach.
European journal of immunology 2005;35(12):3400-4.
2005: Elizabeth A Jones; Richard A Flavell
Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7437-46.
2005: Kosei Ijiri; Luiz F Zerbini; Haibing Peng; Ricardo G Correa; Binfeng Lu; Nicole Walsh; Yani Zhao; Noboru Taniguchi; Xu-Ling Huang; Hasan H Otu; Hong Wang; Jian Fei Wang; Setsuro Komiya; Patricia Ducy; Mahboob U Rahman; Richard A Flavell; Ellen M Gravallese; Peter Oettgen; Towia Libermann; Mary B Goldring
A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation.
The Journal of biological chemistry 2005;280(46):38544-55.
2005: Christina M Lau; Courtney Broughton; Abigail S Tabor; Shizuo Akira; Richard A Flavell; Mark J Mamula; Sean R Christensen; Mark J Shlomchik; Gregory A Viglianti; Ian R Rifkin; Ann Marshak-Rothstein
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.
The Journal of experimental medicine 2005;202(9):1171-7.
2005: Yunfei Gao; Jian Tao; Ming O Li; Dongqing Zhang; Hongbo Chi; Octavian Henegariu; Susan M Kaech; Roger J Davis; Richard A Flavell; Zhinan Yin
JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5783-9.
2005: Alamgir M N Kabir; Xuebin Cao; Diana A Gorog; Masaya Tanno; Rekha Bassi; Mohamed Bellahcene; Roy A Quinlan; Roger J Davis; Richard A Flavell; Michael J Shattock; Michael S Marber
Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3.
Journal of molecular and cellular cardiology 2005;39(4):709-17.
2005: Christopher A Aoki; Andrea T Borchers; Ming O Li; Richard A Flavell; Christopher L Bowlus; Aftab A Ansari; M Eric Gershwin
Transforming growth factor beta (TGF-beta) and autoimmunity.
Autoimmunity reviews 2005;4(7):450-9.
2005: Anna J Zandy; Saquib Lakhani; Timothy Zheng; Richard A Flavell; Steven Bassnett
Role of the executioner caspases during lens development.
The Journal of biological chemistry 2005;280(34):30263-72.
2005: Sean R Christensen; Michael Kashgarian; Lena Alexopoulou; Richard A Flavell; Shizuo Akira; Mark J Shlomchik
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus.
The Journal of experimental medicine 2005;202(2):321-31.
2005: Elizabeth E Eynon; Lauren A Zenewicz; Richard A Flavell
Sugar-coated regulation of T cells.
Cell 2005;122(1):2-4.
2005: Tang-Long Shen; Ann Y-J Park; Ana Alcaraz; Xu Peng; Ihnkyung Jang; Pandelakis Koni; Richard A Flavell; Hua Gu; Jun-Lin Guan
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.
The Journal of cell biology 2005;169(6):941-52.
2005: Tao Zheng; Min Jong Kang; Kristina Crothers; Zhou Zhu; Wei Liu; Chun Geun Lee; Lesley A Rabach; Harold A Chapman; Robert J Homer; David Aldous; George T De Sanctis; George Desanctis; Stephen Underwood; Michael Graupe; Richard A Flavell; John A Schmidt; Jack A Elias
Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):8106-15.
2005: Felix Yarovinsky; Dekai Zhang; John F Andersen; Gerard Bannenberg; Charles N Serhan; Matthew Hayden; Sara Hieny; Fayyaz S Sutterwala; Richard A Flavell; Sankar Ghosh; Alan Sher
TLR11 activation of dendritic cells by a protozoan profilin-like protein.
Science (New York, N.Y.) 2005;308(5728):1626-9.
2005: W Taylor Kimberly; Jessica B Zheng; Terrence Town; Richard A Flavell; Dennis J Selkoe
Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5533-43.
2005: Charalampos Spilianakis; Maria D Lalioti; Terrence Town; Gap Ryol Lee; Richard A Flavell
Interchromosomal associations between alternatively expressed loci.
Nature 2005;435(7042):637-45.
2005: Yasmina Laouar; Fayyaz S Sutterwala; Leonid Gorelik; Richard A Flavell
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.
Nature immunology 2005;6(6):600-7.
2005: J Pablo Abonia; K Frank Austen; Barrett J Rollins; Sunil K Joshi; Richard A Flavell; William Kuziel; Pandelakis Koni; Michael F Gurish
Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2.
Blood 2005;105(11):4308-13.
2005: Anja Jaeschke; Mercedes Rincón; Beth Doran; Judy Reilly; Donna Neuberg; Dale L Greiner; Leonard D Shultz; Aldo A Rossini; Richard A Flavell; Roger J Davis
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6931-5.
2005: Deborah Brancho; Juan-Jose Ventura; Anja Jaeschke; Beth Doran; Richard A Flavell; Roger J Davis
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.
Molecular and cellular biology 2005;25(9):3670-81.
2005: Wajahat Z Mehal; Shehzad Zafar Sheikh; Leonid Gorelik; Richard A Flavell
TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions.
International immunology 2005;17(5):531-8.
2005: Yisong Y Wan; Richard A Flavell
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5126-31.
2005: Hongmei Li; Esteban Cuartas; Weiguo Cui; Yongwon Choi; Todd D Crawford; Hua Zhu Ke; Koichi Kobayashi; Richard A Flavell; Agnès Vignery
IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation.
The Journal of experimental medicine 2005;201(7):1169-77.
2005: Leesun Kim; Laura Del Rio; Barbara A Butcher; Trine H Mogensen; Søren R Paludan; Richard A Flavell; Eric Y Denkers
p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4178-84.
2005: Laxman Dass Gangwani; Richard A Flavell; Roger J Davis
ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.
Molecular and cellular biology 2005;25(7):2744-56.
2005: Hongbo Chi; Matthew Sarkisian; Pasko Rakic; Richard A Flavell
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3846-51.
2005: Linda Fahlén; Simon Read; Leonid Gorelik; Stephen D Hurst; Robert L Coffman; Richard A Flavell; Fiona Powrie
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.
The Journal of experimental medicine 2005;201(5):737-46.
2005: Hongbo Chi; Richard A Flavell
Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2485-8.
2005: Kirk P Townsend; Terrence Town; Takashi Mori; Lih-Fen Lue; Doug Shytle; Paul Sanberg; Dave Morgan; Francisco Fernandez; Richard A Flavell; Jun Tan
CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide.
European journal of immunology 2005;35(3):901-10.
2005: Oliver Schulz; Sandra S Diebold; Margaret Chen; Tanja I Näslund; Martijn A Nolte; Lena Alexopoulou; Yasu-Taka Azuma; Richard A Flavell; Peter Liljeström; Caetano Reis e Sousa
Toll-like receptor 3 promotes cross-priming to virus-infected cells.
Nature 2005;433(7028):887-92.
2005: Margaret S Bynoe; Christophe Viret; Richard A Flavell; Charles A Janeway
T cells from epicutaneously immunized mice are prone to T cell receptor revision.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2898-903.
2005: Koichi Kobayashi; Mathias Chamaillard; Yasunori Ogura; Octavian Henegariu; Naohiro Inohara; Gabriel Nuñez; Richard A Flavell
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.
Science (New York, N.Y.) 2005;307(5710):731-4.
2005: Hyok Joon Kwon; Hee-Sook Jun; Yang Yang; Conchi Mora; Sanjeev Mariathasan; Pamela S Ohashi; Richard A Flavell; Ji-Won Yoon
Development of autoreactive diabetogenic T cells in the thymus of NOD mice.
Journal of autoimmunity 2005;24(1):11-23.
2005: Mei-Ling Chen; Mikaël J Pittet; Leonid Gorelik; Richard A Flavell; Ralph Weissleder; Harald von Boehmer; Khashayarsha Khazaie
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):419-24.
2005: Abdallah Badou; Srisaila Basavappa; Rooma Desai; You-Qing Peng; Didi Matza; Wajahat Z Mehal; Leonard K Kaczmarek; Emile L Boulpaep; Richard A Flavell
Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions.
Science (New York, N.Y.) 2005;307(5706):117-21.
2005: Maria J Fernandez-Cabezudo; Azim Ullah; Richard A Flavell; Basel K al-Ramadi
Evidence for the requirement for CD40-CD154 interactions in resistance to infections with attenuated Salmonella.
Journal of endotoxin research 2005;11(6):395-9.
2005: Terrence Town; Jun Tan; Richard A Flavell; Michael Mullan
T-cells in Alzheimer's disease.
Neuromolecular medicine 2005;7(3):255-64.
2005: Stephan Brecht; Rainer Kirchhof; Ansgar Michael Chromik; Mette Georgi Willesen; Thomas Nicolaus; Gennadij Raivich; Jan Wessig; Vicki Waetzig; Mario Goetz; Malte Claussen; Damien D Pearse; Chia-Yi Kuan; Elisabetta Vaudano; Axel Behrens; Erwin Wagner; Richard A Flavell; Roger J Davis; Thomas Herdegen
Specific pathophysiological functions of JNK isoforms in the brain.
The European journal of neuroscience 2005;21(2):363-77.
2005: Gap Ryol Lee; Charalampos Spilianakis; Richard A Flavell
Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions.
Nature immunology 2005;6(1):42-8.
2004: Masako Miura; Xiao-Dong Chen; Matthew R Allen; Yanming Bi; Stan Gronthos; Byoung-Moo Seo; Saquib Lakhani; Richard A Flavell; Xin-Hua Feng; Pamela Robey; Marian Young; Songtao Shi
A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells.
The Journal of clinical investigation 2004;114(12):1704-13.
2004: Patrick E Fields; Gap Ryol Lee; Sean T Kim; Victor V Bartsevich; Richard A Flavell
Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region.
Immunity 2004;21(6):865-76.
2004: Tian Wang; Terrence Town; Lena Alexopoulou; John F Anderson; Erol Fikrig; Richard A Flavell
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis.
Nature medicine 2004;10(12):1366-73.
2004: Carolina B López; Bruno Moltedo; Lena Alexopoulou; Laura Bonifaz; Richard A Flavell; Thomas M Moran
TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6882-9.
2004: Juan-Jose Ventura; Patricia C Cogswell; Richard A Flavell; Albert S Baldwin; Roger J Davis
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species.
Genes & development 2004;18(23):2905-15.
2004: Chia-Yi Kuan; Aryn Schloemer; Aigang Lu; Kevin A Burns; Wei-Lan Weng; Michael T Williams; Kenneth I Strauss; Charles V Vorhees; Richard A Flavell; Roger J Davis; Frank R Sharp; Pasko Rakic
Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(47):10763-72.
2004: Yuhao Gao; Wei-Ping Qian; Kimberly Dark; Gianluca Toraldo; Angela S P Lin; Robert E Guldberg; Richard A Flavell; Mervyn WEITZMANN; Roberto Pacifici
Estrogen prevents bone loss through transforming growth factor beta signaling in T cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16618-23.
2004: Charalampos Spilianakis; Richard A Flavell
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus.
Nature immunology 2004;5(10):1017-27.
2004: Claire R Weston; Anthony Wong; J Perry Hall; Mary E P Goad; Richard A Flavell; Roger J Davis
The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14114-9.
2004: Holly Y Young; Peter Zucker; Richard A Flavell; Anthony M Jevnikar; Bhagirath Singh
Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation.
Transplantation 2004;78(4):509-15.
2004: Yongliang Zhang; Joseph N Blattman; Norman J Kennedy; Julie Duong; Thang Nguyen; Ying Wang; Roger J Davis; Philip D Greenberg; Richard A Flavell; Chen Dong
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5.
Nature 2004;430(7001):793-7.
2004: Chun Geun Lee; Soo Jung Cho; Min Jong Kang; Svetlana Chapoval; Patty J Lee; Paul W Noble; Teshome Yehualaeshet; Binfeng Lu; Richard A Flavell; Jeffrey Milbrandt; Robert J Homer; Jack A Elias
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.
The Journal of experimental medicine 2004;200(3):377-89.
2004: Benjamin G Scott; Huan Yang; Erdem Tüzün; Chen Dong; Richard A Flavell; Premkumar Christadoss
ICOS is essential for the development of experimental autoimmune myasthenia gravis.
Journal of neuroimmunology 2004;153(1-2):16-25.
2004: Gap Ryol Lee; Richard A Flavell
Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma.
International immunology 2004;16(8):1155-60.
2004: Juan-Jose Ventura; Norman J Kennedy; Richard A Flavell; Roger J Davis
JNK regulates autocrine expression of TGF-beta1.
Molecular cell 2004;15(2):269-78.
2004: Marianna Kulka; Lena Alexopoulou; Richard A Flavell; Dean D Metcalfe
Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3.
The Journal of allergy and clinical immunology 2004;114(1):174-82.
2004: Derk Amsen; Julie M. Blander; Gap Ryol Lee; Kenji Tanigaki; Tasuku Honjo; Richard A Flavell
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.
Cell 2004;117(4):515-26.
2004: Kurt H Edelmann; Sarah M Richardson-Burns; Lena Alexopoulou; Kenneth L Tyler; Richard A Flavell; Michael B A Oldstone
Does Toll-like receptor 3 play a biological role in virus infections?
Virology 2004;322(2):231-8.
2004: Fariba Zare; Maria Bokarewa; Nancy Nenonen; Tomas Bergström; Lena Alexopoulou; Richard A Flavell; Andrej Tarkowski
Arthritogenic properties of double-stranded (viral) RNA.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5656-63.
2004: Georg M N Behrens; Ming Li; Gayle M Davey; Janette Allison; Richard A Flavell; Francis R Carbone; William R Heath
Helper requirements for generation of effector CTL to islet beta cell antigens.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5420-6.
2004: Sangwon V Kim; Richard A Flavell
Immunology. CD8alphaalpha and T cell memory.
Science (New York, N.Y.) 2004;304(5670):529-30.
2004: Jennifer M Lund; Lena Alexopoulou; Ayuko Sato; Margaret L Karow; Niels Adams; nicholas gale; Akiko Iwasaki; Richard A Flavell
Recognition of single-stranded RNA viruses by Toll-like receptor 7.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5598-603.
2004: Hongbo Chi; Binfeng Lu; Mutsuhiro Takekawa; Roger J Davis; Richard A Flavell
GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.
The EMBO journal 2004;23(7):1576-86.
2004: Yufeng Peng; Yasmina Laouar; Ming O Li; E Allison Green; Richard A Flavell
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4572-7.
2004: Akihiko Komuro; Yutaka Masuda; Koichi Kobayashi; Roger Babbitt; Murat Gunel; Richard A Flavell; Vincent T Marchesi
The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(12):4053-8.
2004: Yasmina Laouar; I Nicholas Crispe; Richard A Flavell
Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development.
Blood 2004;103(6):1985-94.
2004: Koichi Tabeta; Philippe Georgel; edith janssen; Xin Du; Kasper Hoebe; Karine Crozat; Suzanne Mudd; Louis Shamel; Sosathya Sovath; Jason Goode; Lena Alexopoulou; Richard A Flavell; Bruce Beutler
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3516-21.
2004: Dekai Zhang; Guolong Zhang; Matthew Hayden; Matthew B Greenblatt; Crystal Bussey; Richard A Flavell; Sankar Ghosh
A toll-like receptor that prevents infection by uropathogenic bacteria.
Science (New York, N.Y.) 2004;303(5663):1522-6.
2004: Jianchao Xu; Peili Wang; Yanyan Li; Guoyong Li; Leonard K Kaczmarek; Yanling Wu; Pandelakis Koni; Richard A Flavell; Gary V Desir
The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3112-7.
2004: Binfeng Lu; Panayiotis Zagouras; James E Fischer; Junfeng Lu; Baiyong Li; Richard A Flavell
Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3023-8.
2004: Erol Fikrig; Patricia K Coyle; Steven E Schutzer; Manchuan Chen; Zhidian Deng; Richard A Flavell
Preferential presence of decorin-binding protein B (BBA25) and BBA50 antibodies in cerebrospinal fluid of patients with neurologic Lyme disease.
Journal of clinical microbiology 2004;42(3):1243-6.
2004: Urs Christen; Rima Darwiche; Helen E Thomas; Tom Wolfe; Evelyn Rodrigo; Alexander V Chervonsky; Richard A Flavell; Matthias G von Herrath
Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells.
Diabetes 2004;53(3):591-6.
2004: Erol Fikrig; Utpal Pal; Manchuan Chen; John F Anderson; Richard A Flavell
OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis.
Infection and immunity 2004;72(3):1755-9.
2004: Koichi Kobayashi; Richard A Flavell
Shielding the double-edged sword: negative regulation of the innate immune system.
Journal of leukocyte biology 2004;75(3):428-33.
2004: G Scott Lichtenberger; Richard A Flavell; Lena Alexopoulou
Innate immunity and apoptosis in IBD.
Inflammatory bowel diseases 2004;10 Suppl 1():S58-62.
2004: Naotoshi Tsuji; Hiroko Tsutsui; Ekihiro Seki; Keisuke Kuida; Haruki Okamura; Kenji Nakanishi; Richard A Flavell
Roles of caspase-1 in Listeria infection in mice.
International immunology 2004;16(2):335-43.
2004: Conchi Mora; Iqbal Grewal; F Susan Wong; Richard A Flavell
Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice.
International immunology 2004;16(2):257-64.
2004: Ruiping Song; Raja Mahidhara; Zhihong Zhou; Rosemary A Hoffman; Dai-Wu Seol; Richard A Flavell; Timothy R Billiar; Leo E Otterbein; Augustine M K Choi
Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1220-6.
2004: Stéphane Hunot; Miquel Vila; Peter Teismann; Roger J Davis; Etienne C Hirsch; Serge Przedborski; Pasko Rakic; Richard A Flavell
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):665-70.
2004: Utpal Pal; Xiaofeng Yang; Manchuan Chen; Linda K Bockenstedt; John F Anderson; Richard A Flavell; Michael V Norgard; Erol Fikrig
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands.
The Journal of clinical investigation 2004;113(2):220-30.
2004: Binfeng Lu; Anthony F Ferrandino; Richard A Flavell
Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells.
Nature immunology 2004;5(1):38-44.
2004: Wei-ping Zheng; Qian Zhao; Xinyan Zhao; Baiyong Li; Mike Hubank; David G Schatz; Richard A Flavell
Up-regulation of Hlx in immature Th cells induces IFN-gamma expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):114-22.
2003: Xinguo Chen; James D Smith; Hong Shi; Derek D Yang; Richard A Flavell; Sandra L Wolin
The Ro autoantigen binds misfolded U2 small nuclear RNAs and assists mammalian cell survival after UV irradiation.
Current biology : CB 2003;13(24):2206-11.
2003: Chia-Yi Kuan; Alan J Whitmarsh; Derek D Yang; Guanghong Liao; Aryn Schloemer; Chen Dong; Jue Bao; Kenneth J Banasiak; Gabriel G Haddad; Richard A Flavell; Roger J Davis; Pasko Rakic
A critical role of neural-specific JNK3 for ischemic apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15184-9.
2003: Lorraine D Hernandez; Marc Pypaert; Richard A Flavell; Jorge E Galán
A Salmonella protein causes macrophage cell death by inducing autophagy.
The Journal of cell biology 2003;163(5):1123-31.
2003: Yasmina Laouar; Thomas Welte; Xin-Yuan Fu; Richard A Flavell
STAT3 is required for Flt3L-dependent dendritic cell differentiation.
Immunity 2003;19(6):903-12.
2003: Changchun Xiao; Jae-hyuck Shim; Michael Klüppel; Samuel Shao-Min Zhang; Chen Dong; Richard A Flavell; Xin-Yuan Fu; Jeffrey L Wrana; Brigid L M Hogan; Sankar Ghosh
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
Genes & development 2003;17(23):2933-49.
2003: Leo E Otterbein; Sherrie L Otterbein; Emeka Ifedigbo; Fang Liu; Danielle E Morse; Colleen Fearns; Richard J Ulevitch; Roy Knickelbein; Richard A Flavell; Augustine M K Choi
MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury.
The American journal of pathology 2003;163(6):2555-63.
2003: Kasper Hoebe; edith janssen; Sung O Kim; Lena Alexopoulou; Richard A Flavell; Jiahuai Han; Bruce Beutler
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.
Nature immunology 2003;4(12):1223-9.
2003: Ming O Li; Matthew Sarkisian; Wajahat Z Mehal; Pasko Rakic; Richard A Flavell
Phosphatidylserine receptor is required for clearance of apoptotic cells.
Science (New York, N.Y.) 2003;302(5650):1560-3.
2003: Arihiro Kano; Michael J Wolfgang; Qian Gao; Jörg J Jacoby; Gui-Xuan Chai; William Hansen; Yoshiki Iwamoto; Jordan S Pober; Richard A Flavell; Xin-Yuan Fu
Endothelial cells require STAT3 for protection against endotoxin-induced inflammation.
The Journal of experimental medicine 2003;198(10):1517-25.
2003: Cleta D'Sa; Barbara J Klocke; Francesco Cecconi; Tullia Lindsten; Craig Thompson; Stanley J Korsmeyer; Richard A Flavell; Kevin A Roth
Caspase regulation of genotoxin-induced neural precursor cell death.
Journal of neuroscience research 2003;74(3):435-45.
2003: Anna-Karin L Robertson; Mats Rudling; Xinghua Zhou; Leonid Gorelik; Richard A Flavell; Göran K Hansson
Disruption of TGF-beta signaling in T cells accelerates atherosclerosis.
The Journal of clinical investigation 2003;112(9):1342-50.
2003: Danielle Morse; Soeren E Pischke; Zhihong Zhou; Roger J Davis; Richard A Flavell; Torsten Loop; Sherrie L Otterbein; Leo E Otterbein; Augustine M K Choi
Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.
The Journal of biological chemistry 2003;278(39):36993-8.
2003: E Allison Green; Leonid Gorelik; Catrin M McGregor; Elise H Tran; Richard A Flavell
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10878-83.
2003: Nyaya Kelkar; Marie-Helene Delmotte; Claire R Weston; Tamera Barrett; Barbara J Sheppard; Richard A Flavell; Roger J Davis
Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9843-8.
2003: Sabyasachi Chakrabarti; Koichi Kobayashi; Richard A Flavell; Carolyn B Marks; Katsuya Miyake; David R Liston; Kimberly T Fowler; Fred S Gorelick; Norma W Andrews
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice.
The Journal of cell biology 2003;162(4):543-9.
2003: Deborah Brancho; Nobuyuki Tanaka; Anja Jaeschke; Juan-Jose Ventura; Nyaya Kelkar; Yoshinori Tanaka; Masanao Kyuuma; Toshikazu Takeshita; Richard A Flavell; Roger J Davis
Mechanism of p38 MAP kinase activation in vivo.
Genes & development 2003;17(16):1969-78.
2003: Masaya Tanno; Rekha Bassi; Diana A Gorog; Adrian T Saurin; Jie Jiang; Richard J Heads; Jody L Martin; Roger J Davis; Richard A Flavell; Michael S Marber
Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.
Circulation research 2003;93(3):254-61.
2003: Gap Ryol Lee; Patrick E Fields; Thomas J Griffin; Richard A Flavell
Regulation of the Th2 cytokine locus by a locus control region.
Immunity 2003;19(1):145-53.
2003: Koichi Kobayashi; Elizabeth E Eynon; Richard A Flavell
Intracellular debugging.
Nature immunology 2003;4(7):652-4.
2003: Koji Eshima; Yongwon Choi; Richard A Flavell
CD154-CD40-independent up-regulation of B7-2 on splenic antigen-presenting cells and efficient T cell priming by staphylococcal enterotoxin A.
International immunology 2003;15(7):817-26.
2003: Danielle Morse; Leo E Otterbein; simon simon watkins; Sean Alber; Zhihong Zhou; Richard A Flavell; Roger J Davis; Augustine M K Choi
Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice.
American journal of physiology. Lung cellular and molecular physiology 2003;285(1):L250-7.
2003: Dahai Xue; Hong Shi; James D Smith; Xinguo Chen; Dennis A Noe; Tommy Cedervall; Derek D Yang; Elizabeth Eynon; Douglas E Brash; Michael Kashgarian; Richard A Flavell; Sandra L Wolin
A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7503-8.
2003: Xuchen Zhang; Peiying Shan; Jawed Alam; Roger J Davis; Richard A Flavell; Patty J Lee
Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury.
The Journal of biological chemistry 2003;278(24):22061-70.
2003: Jennifer A Lamb; Juan-Jose Ventura; Patricia Hess; Richard A Flavell; Roger J Davis
JunD mediates survival signaling by the JNK signal transduction pathway.
Molecular cell 2003;11(6):1479-89.
2003: Roza I Nurieva; Julie Duong; Hiroko Kishikawa; Umberto Dianzani; Jose M Rojo; I cheng Ho; Richard A Flavell; Chen Dong
Transcriptional regulation of th2 differentiation by inducible costimulator.
Immunity 2003;18(6):801-11.
2003: Saquib Lakhani; Richard A Flavell
Caspases and T lymphocytes: a flip of the coin?
Immunological reviews 2003;193():22-30.
2003: Claire R Weston; Anthony Wong; J Perry Hall; Mary E P Goad; Richard A Flavell; Roger J Davis
JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.
Genes & development 2003;17(10):1271-80.
2003: Kresten Skak; Sylvie Guerder; Dominic E Picarella; Nina Brenden; Richard A Flavell; Birgitte K Michelsen
TNF-alpha impairs peripheral tolerance towards beta-cells, and local costimulation by B7.1 enhances the effector function of diabetogenic T cells.
European journal of immunology 2003;33(5):1341-50.
2003: Juan-Jose Ventura; Norman J Kennedy; Jennifer A Lamb; Richard A Flavell; Roger J Davis
c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.
Molecular and cellular biology 2003;23(8):2871-82.
2003: Julie M. Blander; Derek B Sant'Angelo; Daniela Metz; Sang-Won Kim; Richard A Flavell; Kim Bottomly; Charles A Janeway
A pool of central memory-like CD4 T cells contains effector memory precursors.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):2940-8.
2003: Norman J Kennedy; Hayla K Sluss; Stephen N Jones; Dafna Bar-Sagi; Richard A Flavell; Roger J Davis
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.
Genes & development 2003;17(5):629-37.
2003: Roza I Nurieva; Piper Treuting; Julie Duong; Richard A Flavell; Chen Dong
Inducible costimulator is essential for collagen-induced arthritis.
The Journal of clinical investigation 2003;111(5):701-6.
2003: Koji Eshima; Conchi Mora; F Susan Wong; E Allison Green; Iqbal Grewal; Richard A Flavell
A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse.
International immunology 2003;15(3):351-7.
2003: Xuchen Zhang; Peiying Shan; Madhu Sasidhar; Geoffrey L Chupp; Richard A Flavell; Augustine M K Choi; Patty J Lee
Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium.
American journal of respiratory cell and molecular biology 2003;28(3):305-15.
2003: Jianchao Xu; Pandelakis Koni; Peili Wang; Guoyong Li; Leonard Kaczmarek; Yanling Wu; Yanyan Li; Richard A Flavell; Gary V Desir
The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight.
Human molecular genetics 2003;12(5):551-9.
2003: Thomas Welte; Samuel Shao-Min Zhang; Tian Wang; Zhiyuan Zhang; David G T Hesslein; Zhinan Yin; Arihiro Kano; Yoshiki Iwamoto; En Li; Joseph E Craft; Alfred L M Bothwell; Erol Fikrig; Pandelakis Koni; Richard A Flavell; Xin-Yuan Fu
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1879-84.
2003: Silvia F Carambula; James K Pru; Maureen P Lynch; Tiina Matikainen; Paulo Bayard Dias Gonçalves; Richard A Flavell; Jonathan L Tilly; Bo R Rueda
Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice.
Reproductive biology and endocrinology : RB&E 2003;1():15.
2003: Govindarajan Rajagopalan; Yogish C Kudva; Richard A Flavell; Chella S David
Accelerated diabetes in rat insulin promoter-tumor necrosis factor-alpha transgenic nonobese diabetic mice lacking major histocompatibility class II molecules.
Diabetes 2003;52(2):342-7.
2003: Alexei Y Savinov; Andrew Tcherepanov; E Allison Green; Richard A Flavell; Alexander V Chervonsky
Contribution of Fas to diabetes development.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):628-32.
2003: Xuchen Zhang; Peiying Shan; Leo E Otterbein; Jawed Alam; Richard A Flavell; Roger J Davis; Augustine M K Choi; Patty J Lee
Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.
The Journal of biological chemistry 2003;278(2):1248-58.
2003: Yasushi Takai; Jacqueline Canning; Gloria I Perez; James K Pru; Jennifer J Schlezinger; David H Sherr; Richard Kolesnick; Junying Yuan; Richard A Flavell; Stanley J Korsmeyer; Jonathan L Tilly
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.
Endocrinology 2003;144(1):69-74.
2002: Lin Wang; Rui Ma; Richard A Flavell; Mary E Choi
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells.
The Journal of biological chemistry 2002;277(49):47257-62.
2002: M Divya Jyothi; Richard A Flavell; Terrence L Geiger
Targeting autoantigen-specific T cells and suppression of autoimmune encephalomyelitis with receptor-modified T lymphocytes.
Nature biotechnology 2002;20(12):1215-20.
2002: Jun Tan; Terrence Town; Fiona Crawford; Takashi Mori; Anthony DelleDonne; Robert Crescentini; Demian Obregon; Richard A Flavell; Michael Mullan
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.
Nature neuroscience 2002;5(12):1288-93.
2002: Tiffany Horng; Gregory M Barton; Richard A Flavell; Ruslan Medzhitov
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.
Nature 2002;420(6913):329-33.
2002: Dean A Le; Yongqin Wu; Zhihong Huang; Kohji Matsushita; Nikolaus Plesnila; Jean C Augustinack; Bradley T Hyman; Junying Yuan; Keisuke Kuida; Richard A Flavell; Michael A Moskowitz
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15188-93.
2002: Laurie A Whittaker; Naiqian Niu; Ulla-Angela Temann; Amy Stoddard; Richard A Flavell; Anuradha Ray; Robert J Homer; Lauren Cohn
Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9.
American journal of respiratory cell and molecular biology 2002;27(5):593-602.
2002: Patricia Hess; German Pihan; Charles L Sawyers; Richard A Flavell; Roger J Davis
Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.
Nature genetics 2002;32(1):201-5.
2002: Iqbal Grewal; Kate D Grewal; F Susan Wong; Hua Wang; Dominic E Picarella; Charles A Janeway; Richard A Flavell
Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism.
Journal of autoimmunity 2002;19(1-2):9-22.
2002: Jeffrey R Leonard; Barbara J Klocke; Cleta D'Sa; Richard A Flavell; Kevin A Roth
Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice.
Journal of neuropathology and experimental neurology 2002;61(8):673-7.
2002: Nobuyuki Tanaka; Masahito Kamanaka; hervé enslen; Chen Dong; Mark Wysk; Roger J Davis; Richard A Flavell
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis.
EMBO reports 2002;3(8):785-91.
2002: Kirsty Nicolson; Sofia Freland; Catherine Weir; Brett Delahunt; Richard A Flavell; B Thomas Bäckström
Induction of experimental autoimmune encephalomyelitis in the absence of c-Jun N-terminal kinase 2.
International immunology 2002;14(8):849-56.
2002: Lena Alexopoulou; Venetta Thomas; Markus Schnare; Yves Lobet; Juan Anguita; Robert T Schoen; Ruslan Medzhitov; Erol Fikrig; Richard A Flavell
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice.
Nature medicine 2002;8(8):878-84.
2002: Koichi Kobayashi; Lorraine D Hernandez; Jorge E Galán; Charles A Janeway; Ruslan Medzhitov; Richard A Flavell
IRAK-M is a negative regulator of Toll-like receptor signaling.
Cell 2002;110(2):191-202.
2002: Patrick E Fields; Sean T Kim; Richard A Flavell
Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):647-50.
2002: Kui Lei; Anjaruwee Nimnual; Wei-Xing Zong; Norman J Kennedy; Richard A Flavell; Craig Thompson; Dafna Bar-Sagi; Roger J Davis
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.
Molecular and cellular biology 2002;22(13):4929-42.
2002: Juan Anguita; Stephen W Barthold; Rafal Persinski; Michael N Hedrick; Christy A Huy; Roger J Davis; Richard A Flavell; Erol Fikrig
Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6352-7.
2002: Leonid Gorelik; Stephanie L Constant; Richard A Flavell
Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation.
The Journal of experimental medicine 2002;195(11):1499-505.
2002: Dietrich B Conze; Troy Krahl; Norman Kennedy; Linda Weiss; Joanne Lumsden; Patricia Hess; Richard A Flavell; Graham Le Gros; Roger J Davis; Mercedes Rincón
c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation.
The Journal of experimental medicine 2002;195(7):811-23.
2002: Nathalie Arbour; Denise Naniche; Dirk Homann; Roger J Davis; Richard A Flavell; Michael B A Oldstone
c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.
The Journal of experimental medicine 2002;195(7):801-10.
2002: Silvia F Carambula; Tiina Matikainen; Maureen P Lynch; Richard A Flavell; Paulo Bayard Dias Gonçalves; Jonathan L Tilly; Bo R Rueda
Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum.
Endocrinology 2002;143(4):1495-501.
2002: Koichi Kobayashi; Naohiro Inohara; Lorraine D Hernandez; Jorge E Galán; Gabriel Núñez; Charles A Janeway; Ruslan Medzhitov; Richard A Flavell
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.
Nature 2002;416(6877):194-9.
2002: Uwe Koedel; Frank Winkler; Barbara Angele; Adriano Fontana; Richard A Flavell; Hans-Walter Pfister
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice.
Annals of neurology 2002;51(3):319-29.
2002: Qing-Bai She; Nanyue Chen; Ann M Bode; Richard A Flavell; Zigang Dong
Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.
Cancer research 2002;62(5):1343-8.
2002: Jun Tan; Terrence Town; Takashi Mori; Demian Obregon; Yajuan Wu; Anthony DelleDonne; Amyn M Rojiani; Fiona Crawford; Richard A Flavell; Michael Mullan
CD40 is expressed and functional on neuronal cells.
The EMBO journal 2002;21(4):643-52.
2002: Ian Topilski; Alon Harmelin; Richard A Flavell; Yoram Levo; Idit Shachar
Preferential Th1 immune response in invariant chain-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1610-7.
2002: Richard A Flavell; Chen Dong; Roger J Davis
Signaling and cell death in lymphocytes.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(2):80-2.
2002: E Allison Green; Yongwon Choi; Richard A Flavell
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals.
Immunity 2002;16(2):183-91.
2002: Xiaoyu Li; Xia Bu; Binfeng Lu; Hava Avraham; Richard A Flavell; Bing Lim
The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.
Molecular and cellular biology 2002;22(4):1158-71.
2002: Jesús Martínez-Barnetche; Vicente Madrid-Marina; Richard A Flavell; José Moreno
Does CD40 ligation induce B cell negative selection?
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1042-9.
2002: Richard A Flavell
The relationship of inflammation and initiation of autoimmune disease: role of TNF super family members.
Current topics in microbiology and immunology 2002;266():1-9.
2002: Leonid Gorelik; Richard A Flavell
Transforming growth factor-beta in T-cell biology.
Nature reviews. Immunology 2002;2(1):46-53.
2002: Chen Dong; Roger J Davis; Richard A Flavell
MAP kinases in the immune response.
Annual review of immunology 2002;20():55-72.
2002: Ulla-Angela Temann; Prabir Ray; Richard A Flavell
Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology.
The Journal of clinical investigation 2002;109(1):29-39.
2001: Maja Maric; B Arunachalam; Uyen T Phan; Chen Dong; WS Garrett; KS Cannon; C Alfonso; Lars Karlsson; Richard A Flavell; Peter Cresswell
Defective antigen processing in GILT-free mice.
Science (New York, N.Y.) 2001;294(5545):1361-5.
2001: Hong Sun; B Lu; R Q Li; Richard A Flavell; Reshma Taneja
Defective T cell activation and autoimmune disorder in Stra13-deficient mice.
Nature immunology 2001;2(11):1040-7.
2001: Lena Alexopoulou; AC Holt; Ruslan Medzhitov; Richard A Flavell
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
Nature 2001;413(6857):732-8.
2001: Leonid Gorelik; Richard A Flavell
Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells.
Nature medicine 2001;7(10):1118-22.
2001: AU Zaidi; J S McDonough; Barbara J Klocke; Cecelia B Latham; Stanley J Korsmeyer; Richard A Flavell; Robert E Schmidt; Kevin A Roth
Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent.
Journal of neuropathology and experimental neurology 2001;60(10):937-45.
2001: Haiyuan Yu; David Leitenberg; B Li; Richard A Flavell
Deficiency of small GTPase Rac2 affects T cell activation.
The Journal of experimental medicine 2001;194(7):915-26.
2001: Alan J Whitmarsh; Chia-Yi Kuan; Norman J Kennedy; Nyaya Kelkar; Tarik F Haydar; John P Mordes; M Appel; A A Rossini; Stephen N Jones; Richard A Flavell; Pasko Rakic; Roger J Davis
Requirement of the JIP1 scaffold protein for stress-induced JNK activation.
Genes & development 2001;15(18):2421-32.
2001: Mercedes Pérez-Melgosa; Hans D Ochs; Peter Linsley; J D Laman; M van Meurs; Richard A Flavell; Robert Ernst; S I Miller; Christopher B Wilson
Carrier-mediated enhancement of cognate T cell help: the basis for enhanced immunogenicity of meningococcal outer membrane protein polysaccharide conjugate vaccine.
European journal of immunology 2001;31(8):2373-81.
2001: Hsin-Jung Wu; Chandrasekar Venkataraman; Steven Estus; C Dong; R J Davis; Richard A Flavell; Subbarao Bondada
Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1263-73.
2001: Chen Dong; Roger J Davis; Richard A Flavell
Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase.
Journal of clinical immunology 2001;21(4):253-7.
2001: Shane R Bruckner; Steven Tammariello; Chia-Yi Kuan; Richard A Flavell; P Rakic; Steven Estus
JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons.
Journal of neurochemistry 2001;78(2):298-303.
2001: Urs Christen; Tom Wolfe; Ursula Möhrle; A C Hughes; Evelyn Rodrigo; E A Green; Richard A Flavell; Matthias G von Herrath
A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7023-32.
2001: C Tournier; Chen Dong; Tod K Turner; Stephen N Jones; Richard A Flavell; Roger J Davis
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines.
Genes & development 2001;15(11):1419-26.
2001: Tiina Matikainen; Gloria I Perez; T S Zheng; T R Kluzak; Bo R Rueda; Richard A Flavell; Jonathan L Tilly
Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary.
Endocrinology 2001;142(6):2468-80.
2001: Nanyue Chen; M Nomura; Qing-Bai She; Wei-Ya Ma; Ann M Bode; L Wang; Richard A Flavell; Zigang Dong
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.
Cancer research 2001;61(10):3908-12.
2001: Stéphane Hunot; Richard A Flavell
Apoptosis. Death of a monopoly?
Science (New York, N.Y.) 2001;292(5518):865-6.
2001: B Lu; H Yu; Chi-Wing Chow; B Li; W Zheng; Roger J Davis; Richard A Flavell
GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells.
Immunity 2001;14(5):583-90.
2001: M Rincón; Richard A Flavell; R J Davis
Signal transduction by MAP kinases in T lymphocytes.
Oncogene 2001;20(19):2490-7.
2001: Gap Ryol Lee; Patrick E Fields; Richard A Flavell
Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level.
Immunity 2001;14(4):447-59.
2001: Pandelakis Koni; Sunil K Joshi; U A Temann; D Olson; L Burkly; Richard A Flavell
Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow.
The Journal of experimental medicine 2001;193(6):741-54.
2001: Chen Dong; Ulla-Angela Temann; Richard A Flavell
Cutting edge: critical role of inducible costimulator in germinal center reactions.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3659-62.
2001: Chen Dong; Amy E Juedes; Ulla-Angela Temann; S Shresta; J P Allison; Nancy H Ruddle; Richard A Flavell
ICOS co-stimulatory receptor is essential for T-cell activation and function.
Nature 2001;409(6816):97-101.
2001: AU Zaidi; C D'Sa-Eipper; J Brenner; Keisuke Kuida; TS Zheng; Richard A Flavell; Pasko Rakic; Kevin A Roth
Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(1):169-75.
2001: C D'Sa-Eipper; Jeffrey R Leonard; G Putcha; TS Zheng; Richard A Flavell; Pasko Rakic; Keisuke Kuida; Kevin A Roth
DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3.
Development (Cambridge, England) 2001;128(1):137-46.
2000: Liat Flaishon; Rami Hershkoviz; Frida Lantner; Ofer Lider; Ronen Alon; Yoram Levo; Richard A Flavell; Idit Shachar
Autocrine secretion of interferon gamma negatively regulates homing of immature B cells.
The Journal of experimental medicine 2000;192(9):1381-8.
2000: Reinhard E Voll; Eijiro Jimi; Roderick J Phillips; Domingo F Barber; Mercedes Rincon; Adrian C Hayday; Richard A Flavell; Sankar Ghosh
NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development.
Immunity 2000;13(5):677-89.
2000: Tongzhang Zheng; Stéphane Hunot; Keisuke Kuida; T Momoi; A Srinivasan; D W Nicholson; Y Lazebnik; Richard A Flavell
Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation.
Nature medicine 2000;6(11):1241-7.
2000: Leonid Gorelik; Patrick E Fields; Richard A Flavell
Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4773-7.
2000: Chen Dong; Richard A Flavell
Control of T helper cell differentiation--in search of master genes.
Science's STKE : signal transduction knowledge environment 2000;2000(49):pe1.
2000: Laura Manuelidis; I Zaitsev; Pandelakis Koni; Zhi Yun Lu; Richard A Flavell; W Fritch
Follicular dendritic cells and dissemination of Creutzfeldt-Jakob disease.
Journal of virology 2000;74(18):8614-22.
2000: Stephanie L Constant; Chen Dong; Derek D Yang; Mark Wysk; Roger J Davis; Richard A Flavell
JNK1 is required for T cell-mediated immunity against Leishmania major infection.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2671-6.
2000: Feng Zhang; M Rincon; Richard A Flavell; Thomas M Aune
Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1762-70.
2000: Chi-Wing Chow; Chen Dong; Richard A Flavell; Roger J Davis
c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1.
Molecular and cellular biology 2000;20(14):5227-34.
2000: B Li; Haiyuan Yu; W Zheng; Reinhard E Voll; S Na; A W Roberts; D A Williams; Roger J Davis; Sankar Ghosh; Richard A Flavell
Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation.
Science (New York, N.Y.) 2000;288(5474):2219-22.
2000: Isabelle Millet; Roderick J Phillips; Robert S Sherwin; Sankar Ghosh; R E Voll; Richard A Flavell; Agnès Vignery; Mercedes Rincón
Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide.
The Journal of biological chemistry 2000;275(20):15114-21.
2000: Erol Fikrig; W Feng; Stephen W Barthold; Sam R Telford; Richard A Flavell
Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5344-51.
2000: C Tournier; P Hess; Derek D Yang; Jianchao Xu; Tod K Turner; Anjaruwee Nimnual; Dafna Bar-Sagi; Stephen N Jones; Richard A Flavell; Roger J Davis
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.
Science (New York, N.Y.) 2000;288(5467):870-4.
2000: Chen Dong; Derek D Yang; C Tournier; Alan J Whitmarsh; Jianchao Xu; Roger J Davis; Richard A Flavell
JNK is required for effector T-cell function but not for T-cell activation.
Nature 2000;405(6782):91-4.
2000: E Allison Green; Richard A Flavell
The temporal importance of TNFalpha expression in the development of diabetes.
Immunity 2000;12(5):459-69.
2000: Mercedes Rincón; Dietrich B Conze; Linda Weiss; NL Diehl; Karen A Fortner; D Yang; Richard A Flavell; hervé enslen; Alan J Whitmarsh; Roger J Davis
Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?
Immunology and cell biology 2000;78(2):166-75.
2000: LA Selznick; TS Zheng; Richard A Flavell; Pasko Rakic; Kevin A Roth
Amyloid beta-induced neuronal death is bax-dependent but caspase-independent.
Journal of neuropathology and experimental neurology 2000;59(4):271-9.
2000: Leo E Otterbein; F H Bach; Jawed Alam; M Soares; H Tao Lu; Mark Wysk; Roger J Davis; Richard A Flavell; Augustine M K Choi
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway.
Nature medicine 2000;6(4):422-8.
2000: Adrian Bot; Andreas Holz; Urs Christen; Tom Wolfe; A Temann; Richard A Flavell; Matthias von Herrath
Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses.
Virology 2000;269(1):66-77.
2000: Philippe Pierre; Idit Shachar; Didi Matza; Evelina Gatti; Richard A Flavell; Ira Mellman
Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells.
The Journal of experimental medicine 2000;191(6):1057-62.
2000: Leonid Gorelik; Richard A Flavell
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease.
Immunity 2000;12(2):171-81.
2000: NL Diehl; hervé enslen; Karen A Fortner; C Merritt; N Stetson; Colette Charland; Richard A Flavell; Roger J Davis; Mercedes Rincón
Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo.
The Journal of experimental medicine 2000;191(2):321-34.
2000: E Allison Green; F Susan Wong; Koji Eshima; Conchi Mora; Richard A Flavell
Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells.
The Journal of experimental medicine 2000;191(2):225-38.
2000: Kevin A Roth; Chia-Yi Kuan; Tarik F Haydar; C D'Sa-Eipper; Kenneth Shindler; TS Zheng; Keisuke Kuida; Richard A Flavell; Pasko Rakic
Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):466-71.
2000: Linda Weiss; Alan J Whitmarsh; Derek D Yang; Mercedes Rincón; Roger J Davis; Richard A Flavell
Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation.
The Journal of experimental medicine 2000;191(1):139-46.
2000: Li Wen; F Susan Wong; J Tang; ningyuan chen; M Altieri; Chella S David; Richard A Flavell; Robert S Sherwin
In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes.
The Journal of experimental medicine 2000;191(1):97-104.
1999: S Na; B Li; Iqbal Grewal; hervé enslen; R J Davis; J H Hanke; Richard A Flavell
Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways.
Oncogene 1999;18(56):7966-74.
1999: E Allison Green; Richard A Flavell
The initiation of autoimmune diabetes.
Current opinion in immunology 1999;11(6):663-9.
1999: Ottavio Cremona; Gilbert Di Paolo; Markus R Wenk; A Lüthi; W T Kim; Kohji Takei; Laurie Daniell; Y Nemoto; S B Shears; Richard A Flavell; David A McCormick; Pietro De Camilli
Essential role of phosphoinositide metabolism in synaptic vesicle recycling.
Cell 1999;99(2):179-88.
1999: Jason K Whitmire; Richard A Flavell; Iqbal Grewal; Christian P Larsen; Thomas C Pearson; Rafi Ahmed
CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3194-201.
1999: DP Berger; Denise Naniche; M T Crowley; Pandelakis Koni; Richard A Flavell; Michael B A Oldstone
Lymphotoxin-beta-deficient mice show defective antiviral immunity.
Virology 1999;260(1):136-47.
1999: R Ballica; Karin Valentijn; A Khachatryan; S Guerder; S Kapadia; Caren M Gundberg; J Gilligan; Richard A Flavell; Agnès Vignery
Targeted expression of calcitonin gene-related peptide to osteoblasts increases bone density in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(7):1067-74.
1999: E Allison Green; Richard A Flavell
Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic mice.
Immunological reviews 1999;169():11-22.
1999: Elizabeth Eynon; Richard A Flavell
Walking through the forest of transgenic models of human disease.
Immunological reviews 1999;169():5-10.
1999: T L Geiger; David Leitenberg; Richard A Flavell
The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5931-9.
1999: Conchi Mora; F Susan Wong; Cheong-Hee Chang; Richard A Flavell
Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4576-88.
1999: E Allison Green; Richard A Flavell
TRANCE-RANK, a new signal pathway involved in lymphocyte development and T cell activation.
The Journal of experimental medicine 1999;189(7):1017-20.
1999: Chia-Yi Kuan; Derek D Yang; D R Samanta Roy; Roger J Davis; Pasko Rakic; Richard A Flavell
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.
Neuron 1999;22(4):667-76.
1999: HT Lu; Derek D Yang; Mark Wysk; Evelina Gatti; Ira Mellman; Roger J Davis; Richard A Flavell
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice.
The EMBO journal 1999;18(7):1845-57.
1999: Mark Wysk; Derek D Yang; HT Lu; Richard A Flavell; Roger J Davis
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3763-8.
1999: Tania S Gourley; S Roys; Nicholas W Lukacs; Steven Kunkel; Richard A Flavell; Cheong-Hee Chang
A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production.
Immunity 1999;10(3):377-86.
1999: Pandelakis Koni; Richard A Flavell
Lymph node germinal centers form in the absence of follicular dendritic cell networks.
The Journal of experimental medicine 1999;189(5):855-64.
1999: Elizabeth Eynon; Ferenc Livak; Keisuke Kuida; David G Schatz; Richard A Flavell
Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1448-59.
1999: B Li; C Tournier; Roger J Davis; Richard A Flavell
Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.
The EMBO journal 1999;18(2):420-32.
1999: Richard A Flavell; B Li; Chen Dong; HT Lu; Derek D Yang; hervé enslen; C Tournier; Alan J Whitmarsh; Mark Wysk; Dietrich B Conze; M Rincon; Roger J Davis
Molecular basis of T-cell differentiation.
Cold Spring Harbor symposia on quantitative biology 1999;64():563-71.
1999: Mercedes Rincón; Richard A Flavell
Reprogramming transcription during the differentiation of precursor CD4+ T cells into effector Th1 and Th2 cells.
Microbes and infection / Institut Pasteur 1999;1(1):43-50.
1999: Richard A Flavell
The molecular basis of T cell differentiation.
Immunologic research 1999;19(2-3):159-68.
1999: Charles A Janeway; Richard A Flavell
Immunology at Yale.
Immunologic research 1999;19(2-3):105-6.
1999: Erol Fikrig; Manchuan Chen; Stephen W Barthold; Juan Anguita; W Feng; Sam R Telford; Richard A Flavell
Borrelia burgdorferi erpT expression in the arthropod vector and murine host.
Molecular microbiology 1999;31(1):281-90.
1998: Chen Dong; Derek D Yang; Mark Wysk; Alan J Whitmarsh; Roger J Davis; Richard A Flavell
Defective T cell differentiation in the absence of Jnk1.
Science (New York, N.Y.) 1998;282(5396):2092-5.
1998: Feng Zhang; D Z Wang; Mark Boothby; LA Penix; Richard A Flavell; Thomas M Aune
Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6105-12.
1998: Mercedes Rincón; Alan J Whitmarsh; Derek D Yang; Linda Weiss; B Dérijard; P Jayaraj; Roger J Davis; Richard A Flavell
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes.
The Journal of experimental medicine 1998;188(10):1817-30.
1998: T S Zheng; SF Schlosser; T Dao; R Hingorani; I Nicholas Crispe; James L Boyer; Richard A Flavell
Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13618-23.
1998: E Allison Green; Elizabeth Eynon; Richard A Flavell
Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens.
Immunity 1998;9(5):733-43.
1998: Juan Anguita; Mercedes Rincón; Swapna Samanta; Stephen W Barthold; Richard A Flavell; Erol Fikrig
Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis.
The Journal of infectious diseases 1998;178(5):1512-5.
1998: Ulla-Angela Temann; Gregory P Geba; JA Rankin; Richard A Flavell
Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness.
The Journal of experimental medicine 1998;188(7):1307-20.
1998: Derek D Yang; Dietrich B Conze; Alan J Whitmarsh; T Barrett; Roger J Davis; Mercedes Rincón; Richard A Flavell
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.
Immunity 1998;9(4):575-85.
1998: Erol Fikrig; W Feng; J Aversa; Robert T Schoen; Richard A Flavell
Differential expression of Borrelia burgdorferi genes during erythema migrans and Lyme arthritis.
The Journal of infectious diseases 1998;178(4):1198-201.
1998: Richard A Flavell; Mercedes Rincón; W P Zheng; B Li; hervé enslen; J Raingeaud; Roger J Davis
The regulation of CD4 T cell differentiation.
European cytokine network 1998;9(3 Suppl):26-32.
1998: Li Wen; F Susan Wong; L Burkly; M Altieri; Clio Mamalaki; D Kioussis; Richard A Flavell; Robert S Sherwin
Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice.
The Journal of clinical investigation 1998;102(5):947-57.
1998: S Guerder; Elizabeth Eynon; Richard A Flavell
Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2128-40.
1998: Persephone Borrow; David F Tough; Danelle S Eto; Antoinette Tishon; Iqbal Grewal; Jonathan Sprent; Richard A Flavell; Michael B A Oldstone
CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection.
Journal of virology 1998;72(9):7440-9.
1998: L Geng; Michele Solimena; Richard A Flavell; Robert S Sherwin; Adrian C Hayday
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10055-60.
1998: F Susan Wong; Irene Visintin; Li Wen; J Granata; Richard A Flavell; Charles A Janeway
The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice.
The Journal of experimental medicine 1998;187(12):1985-93.
1998: Pandelakis Koni; Richard A Flavell
A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin beta.
The Journal of experimental medicine 1998;187(12):1977-83.
1998: Mercedes Rincón; hervé enslen; J Raingeaud; M Recht; T Zapton; M S Su; L A Penix; Roger J Davis; Richard A Flavell
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway.
The EMBO journal 1998;17(10):2817-29.
1998: Iqbal Grewal; Richard A Flavell
CD40 and CD154 in cell-mediated immunity.
Annual review of immunology 1998;16():111-35.
1997: Erol Fikrig; Stephen W Barthold; Manchuan Chen; Cheong-Hee Chang; Richard A Flavell
Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5682-6.
1997: Aurelio Lorico; Germana Rappa; Rick A Finch; D Yang; Richard A Flavell; Alan C Sartorelli
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.
Cancer research 1997;57(23):5238-42.
1997: Germana Rappa; Aurelio Lorico; Richard A Flavell; Alan C Sartorelli
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.
Cancer research 1997;57(23):5232-7.
1997: Prabir Ray; W Tang; Peili Wang; Robert J Homer; C Kuhn; Richard A Flavell; Jack A Elias
Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.
The Journal of clinical investigation 1997;100(10):2501-11.
1997: M Rincón; Richard A Flavell
T-cell subsets: transcriptional control in the Th1/Th2 decision.
Current biology : CB 1997;7(11):R729-32.
1997: L Gu; BJ Rutledge; J Fiorillo; C Ernst; Iqbal Grewal; Richard A Flavell; R Gladue; Barrett J Rollins
In vivo properties of monocyte chemoattractant protein-1.
Journal of leukocyte biology 1997;62(5):577-80.
1997: Derek D Yang; Chia-Yi Kuan; Alan J Whitmarsh; Mercedes Rincón; T S Zheng; Roger J Davis; Pasko Rakic; Richard A Flavell
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.
Nature 1997;389(6653):865-70.
1997: Y Eugene Chin; M Kitagawa; Keisuke Kuida; Richard A Flavell; Xin-Yuan Fu
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.
Molecular and cellular biology 1997;17(9):5328-37.
1997: Iqbal Grewal; Persephone Borrow; Eric G Pamer; M B Oldstone; Richard A Flavell
The CD40-CD154 system in anti-infective host defense.
Current opinion in immunology 1997;9(4):491-7.
1997: N Nogués; José A del Río; M Pérez-Riba; E Soriano; Richard A Flavell; Albert Boronat
Placenta-specific expression of the rat growth hormone-releasing hormone gene promoter in transgenic mice.
Endocrinology 1997;138(8):3222-7.
1997: Iqbal Grewal; BJ Rutledge; J A Fiorillo; L Gu; Ronald P Gladue; Richard A Flavell; Barrett J Rollins
Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):401-8.
1997: T M Aune; Richard A Flavell
Differential expression of transcription directed by a discrete NF-AT binding element from the IL-4 promoter in naive and effector CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):36-43.
1997: Lynn Soong; Cheong-Hee Chang; J Sun; B Jack Longley; Nancy H Ruddle; Richard A Flavell; Diane McMahon-Pratt
Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5374-83.
1997: Chuanshu Huang; Wei-Ya Ma; M I Dawson; M Rincon; Richard A Flavell; Zigang Dong
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5826-30.
1997: W Zheng; Richard A Flavell
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.
Cell 1997;89(4):587-96.
1997: Mercedes Rincón; Richard A Flavell
Regulation of the activity of the transcription factors AP-1 and NFAT during differentiation of precursor CD4+ T-cells into effector cells.
Biochemical Society transactions 1997;25(2):347-54.
1997: Erol Fikrig; Stephen W Barthold; W Sun; W Feng; Sam R Telford; Richard A Flavell
Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity.
Immunity 1997;6(5):531-9.
1997: Alexander V Chervonsky; Yuqi Wang; F Susan Wong; Irene Visintin; Richard A Flavell; Charles A Janeway; LA Matis
The role of Fas in autoimmune diabetes.
Cell 1997;89(1):17-24.
1997: Pandelakis Koni; R Sacca; P Lawton; Jeffrey L Browning; Nancy H Ruddle; Richard A Flavell
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice.
Immunity 1997;6(4):491-500.
1997: Ulla-Angela Temann; B Prasad; Marianne Gallup; C Basbaum; S B Ho; Richard A Flavell; JA Rankin
A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion.
American journal of respiratory cell and molecular biology 1997;16(4):471-8.
1997: Chia-Yi Kuan; E A Elliott; Richard A Flavell; Pasko Rakic
Restrictive clonal allocation in the chimeric mouse brain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3374-9.
1997: D Yang; C Tournier; Mark Wysk; HT Lu; Jianchao Xu; Roger J Davis; Richard A Flavell
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3004-9.
1997: Erol Fikrig; Stephen W Barthold; Manchuan Chen; H Tao; Pia Ali-Salaam; Linda K Bockenstedt; Richard A Flavell
Lyme borreliosis in transgenic mice tolerant to OspA from Borrelia burgdorferi 25015.
The Journal of infectious diseases 1997;175(4):1000-3.
1997: T Nakamura; Richard Lee; S Y Nam; Eckhard R Podack; Kim Bottomly; Richard A Flavell
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2648-53.
1997: Stanford L Peng; Jennifer M McNiff; Michael P. Madaio; J Ma; MJ Owen; Richard A Flavell; Adrian C Hayday; Joe Craft
alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2464-70.
1997: T Nakamura; Richard Lee; S Y Nam; Basel K al-Ramadi; Pandelakis Koni; Kim Bottomly; Eckhard R Podack; Richard A Flavell
Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2090-8.
1997: Mercedes Rincón; Richard A Flavell
Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells.
Molecular and cellular biology 1997;17(3):1522-34.
1997: Mercedes Rincón; Juan Anguita; T Nakamura; Erol Fikrig; Richard A Flavell
Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells.
The Journal of experimental medicine 1997;185(3):461-9.
1997: Mercedes Rincón; B Dérijard; Chi-Wing Chow; Roger J Davis; Richard A Flavell
Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells.
Genes and function 1997;1(1):51-68.
1997: Iqbal Grewal; Richard A Flavell
The CD40 ligand. At the center of the immune universe?
Immunologic research 1997;16(1):59-70.
1997: A Khachatryan; S Guerder; F Palluault; G Cote; Michele Solimena; Karin Valentijn; Isabelle Millet; Richard A Flavell; Agnès Vignery
Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1409-16.
1997: T Nakamura; Y Kamogawa; Kim Bottomly; Richard A Flavell
Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1085-94.
1997: Iqbal Grewal; Richard A Flavell
New insights into insulin dependent diabetes mellitus from studies with transgenic mouse models.
Laboratory investigation; a journal of technical methods and pathology 1997;76(1):3-10.
1997: T M Aune; LA Penix; Mercedes Rincón; Richard A Flavell
Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells.
Molecular and cellular biology 1997;17(1):199-208.
1996: W Tang; Gregory P Geba; Tao Zheng; Prabir Ray; Robert J Homer; C Kuhn; Richard A Flavell; Jack A Elias
Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.
The Journal of clinical investigation 1996;98(12):2845-53.
1996: Linda K Bockenstedt; Erol Fikrig; Stephen W Barthold; Richard A Flavell; Fred S Kantor
Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5496-502.
1996: Aurelio Lorico; Germana Rappa; Richard A Flavell; Alan C Sartorelli
Double knockout of the MRP gene leads to increased drug sensitivity in vitro.
Cancer research 1996;56(23):5351-5.
1996: Keisuke Kuida; T S Zheng; S Na; Chia-Yi Kuan; D Yang; H Karasuyama; Pasko Rakic; Richard A Flavell
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice.
Nature 1996;384(6607):368-72.
1996: Subrata Das; D Shraga; C Gannon; T T Lam; Sunlian Feng; L R Brunet; S R Telford; Stephen W Barthold; Richard A Flavell; Erol Fikrig
Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue.
Research in microbiology 1996;147(9):739-51.
1996: Iqbal Grewal; K D Grewal; F Susan Wong; D E Picarella; Charles A Janeway; Richard A Flavell
Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.
The Journal of experimental medicine 1996;184(5):1963-74.
1996: I Shachar; Richard A Flavell
Requirement for invariant chain in B cell maturation and function.
Science (New York, N.Y.) 1996;274(5284):106-8.
1996: Iqbal Grewal; Richard A Flavell
The role of CD40 ligand in costimulation and T-cell activation.
Immunological reviews 1996;153():85-106.
1996: Iqbal Grewal; H G Foellmer; K D Grewal; J Xu; F Hardardottir; J L Baron; Charles A Janeway; Richard A Flavell
Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis.
Science (New York, N.Y.) 1996;273(5283):1864-7.
1996: Elizabeth Eynon; Keisuke Kuida; Richard A Flavell
Disruption of cytokine signaling in lymphoid development: unique contributions of the common cytokine gamma chain and the Jak3 kinase.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(9):677-84.
1996: Iqbal Grewal; Richard A Flavell
A central role of CD40 ligand in the regulation of CD4+ T-cell responses.
Immunology today 1996;17(9):410-4.
1996: A Cariappa; D C Flyer; C T Rollins; D C Roopenian; Richard A Flavell; D Brown; G L Waneck
Glycosylphosphatidylinositol-anchored H-2Db molecules are defective in antigen processing and presentation to cytotoxic T lymphocytes.
European journal of immunology 1996;26(9):2215-24.
1996: J A Rankin; D E Picarella; Gregory P Geba; Ulla-Angela Temann; B Prasad; B DiCosmo; A Tarallo; B Stripp; Jeffrey A Whitsett; Richard A Flavell
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7821-5.
1996: J Ma; J Xu; Michael P. Madaio; Q Peng; J Zhang; Iqbal Grewal; Richard A Flavell; Joe Craft
Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):417-26.
1996: Erol Fikrig; Stephen W Barthold; Manchuan Chen; Iqbal Grewal; Joe Craft; Richard A Flavell
Protective antibodies in murine Lyme disease arise independently of CD40 ligand.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):1-3.
1996: Junhui Zhang; S Hagopian-Donaldson; G Serbedzija; J Elsemore; D Plehn-Dujowich; A P McMahon; Richard A Flavell; Trevor Williams
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2.
Nature 1996;381(6579):238-41.
1996: Persephone Borrow; Antoinette Tishon; S Lee; J Xu; Iqbal Grewal; Michael B A Oldstone; Richard A Flavell
CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.
The Journal of experimental medicine 1996;183(5):2129-42.
1996: John F Anderson; Richard A Flavell; Louis A Magnarelli; Stephen W Barthold; Fred S Kantor; Reinhard Wallich; David H Persing; D Mathiesen; Erol Fikrig
Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans.
Journal of clinical microbiology 1996;34(3):524-9.
1996: Lynn Soong; J C Xu; Iqbal Grewal; Peter E Kima; J Sun; B J Longley; Nancy H Ruddle; Diane McMahon-Pratt; Richard A Flavell
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.
Immunity 1996;4(3):263-73.
1996: M Rincon; Richard A Flavell
Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells.
Molecular and cellular biology 1996;16(3):1074-84.
1996: Jack A Elias; Gregory P Geba; W Tang; R Schilz; Tao Zheng; B DiCosmo; Richard A Flavell
Transgenic modeling of cytokines in the investigation of pulmonary disease.
Chest 1996;109(3 Suppl):69S-73S.
1996: Louis A Magnarelli; Erol Fikrig; SJ Padula; John F Anderson; Richard A Flavell
Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of lyme borreliosis.
Journal of clinical microbiology 1996;34(2):237-40.
1996: J Xu; Iqbal Grewal; Gregory P Geba; Richard A Flavell
Impaired primary T cell responses in L-selectin-deficient mice.
The Journal of experimental medicine 1996;183(2):589-98.
1996: Richard A Flavell; A Kratz; Nancy H Ruddle
The contribution of insulitis to diabetes development in tumor necrosis factor transgenic mice.
Current topics in microbiology and immunology 1996;206():33-50.
1996: F Susan Wong; Irene Visintin; Li Wen; Richard A Flavell; Charles A Janeway
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
The Journal of experimental medicine 1996;183(1):67-76.
1995: Erol Fikrig; B Liu; L L Fu; Subrata Das; J I Smallwood; Richard A Flavell; David H Persing; Robert T Schoen; Stephen W Barthold; Stephen E Malawista
An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5700-4.
1995: G Soldevila; T Geiger; Richard A Flavell
Breaking immunologic ignorance to an antigenic peptide of simian virus 40 large T antigen.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5590-600.
1995: Iqbal Grewal; J Xu; Richard A Flavell
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand.
Nature 1995;378(6557):617-20.
1995: M G von Herrath; S Guerder; Hanna Lewicki; Richard A Flavell; Michael B A Oldstone
Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes.
Immunity 1995;3(6):727-38.
1995: S Guerder; Simon R Carding; Richard A Flavell
B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5167-74.
1995: Erol Fikrig; H Tao; Manchuan Chen; Stephen W Barthold; Richard A Flavell
Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.
The Journal of clinical investigation 1995;96(4):1706-14.
1995: B Jwang; P Dewing; Erol Fikrig; Richard A Flavell
The hook protein of Borrelia burgdorferi, encoded by the flgE gene, is serologically recognized in Lyme disease.
Clinical and diagnostic laboratory immunology 1995;2(5):609-15.
1995: Sunlian Feng; Subrata Das; T Lam; Richard A Flavell; Erol Fikrig
A 55-kilodalton antigen encoded by a gene on a Borrelia burgdorferi 49-kilobase plasmid is recognized by antibodies in sera from patients with Lyme disease.
Infection and immunity 1995;63(9):3459-66.
1995: I Shachar; E A Elliott; B Chasnoff; Iqbal Grewal; Richard A Flavell
Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms.
Immunity 1995;3(3):373-83.
1995: Cheong-Hee Chang; Soon-Cheol Hong; C C Hughes; Charles A Janeway; Richard A Flavell
CIITA activates the expression of MHC class II genes in mouse T cells.
International immunology 1995;7(9):1515-8.
1995: S Guerder; Richard A Flavell
T-cell activation. Two for T.
Current biology : CB 1995;5(8):866-8.
1995: Louis A Magnarelli; John F Anderson; Richard A Flavell; Erol Fikrig
Reactivity of white-footed mouse and raccoon sera to whole cell and recombinant antigens of Borrelia burgdorferi.
Journal of wildlife diseases 1995;31(3):339-44.
1995: S Cretella; S Gordon; Richard A Flavell; Erol Fikrig
Evaluation of a Lyme disease enzyme immunoassay using the 41-G fragment of flagellin.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1995;14(7):609-13.
1995: Alexander V Chervonsky; J Xu; A K Barlow; M Khery; Richard A Flavell; Charles A Janeway
Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV.
Immunity 1995;3(1):139-46.
1995: S J Antonia; T Muñoz-Antonia; G Soldevila; J Miller; Richard A Flavell
B7-1 expression by a non-antigen presenting cell-derived tumor.
Cancer research 1995;55(11):2253-6.
1995: Stephanie L Constant; Derek B Sant'Angelo; T Pasqualini; T Taylor; D Levin; Richard A Flavell; Kim Bottomly
Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):4915-23.
1995: K Suk; Subrata Das; W Sun; B Jwang; Stephen W Barthold; Richard A Flavell; Erol Fikrig
Borrelia burgdorferi genes selectively expressed in the infected host.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4269-73.
1995: S R Telford; Fred S Kantor; Yves LOBET; Stephen W Barthold; Andrew Spielman; Richard A Flavell; Erol Fikrig
Efficacy of human Lyme disease vaccine formulations in a mouse model.
The Journal of infectious diseases 1995;171(5):1368-70.
1995: Erol Fikrig; H Tao; Stephen W Barthold; Richard A Flavell
Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B.
Infection and immunity 1995;63(5):1658-62.
1995: S J Antonia; T Geiger; J Miller; Richard A Flavell
Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein.
International immunology 1995;7(5):715-25.
1995: M Dunne; Basel K al-Ramadi; Stephen W Barthold; Richard A Flavell; Erol Fikrig
Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis.
Infection and immunity 1995;63(4):1611-4.
1995: Keisuke Kuida; J A Lippke; George Ku; MW Harding; David J Livingston; Michael S S Su; Richard A Flavell
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
Science (New York, N.Y.) 1995;267(5206):2000-3.
1995: B DiCosmo; Gregory P Geba; D Picarella; Jack A Elias; J A Rankin; B Stripp; Jeffrey A Whitsett; Richard A Flavell
Expression of interleukin-6 by airway epithelial cells. Effects on airway inflammation and hyperreactivity in transgenic mice.
Chest 1995;107(3 Suppl):131S.
1995: J Longley; T G Ding; D Levin; J Lewis; R Edelson; R Tigelaar; Richard A Flavell
Regulation of transgenic class II major histocompatibility genes in murine Langerhans cells.
The Journal of investigative dermatology 1995;104(3):329-34.
1995: S Wong; S Guerder; Irene Visintin; E P Reich; K E Swenson; Richard A Flavell; Charles A Janeway
Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse.
Diabetes 1995;44(3):326-9.
1995: Cheong-Hee Chang; Richard A Flavell
Class II transactivator regulates the expression of multiple genes involved in antigen presentation.
The Journal of experimental medicine 1995;181(2):765-7.
1995: S Guerder; Richard A Flavell
Costimulation in tolerance and autoimmunity.
International reviews of immunology 1995;13(2):135-46.
1995: T Nakamura; Mercedes Rincón; Y Kamogawa; Richard A Flavell
Regulation of CD4+ T cell differentiation.
Ciba Foundation symposium 1995;195():154-68; discussion 168-72.
1995: Erol Fikrig; S R Telford; Reinhard Wallich; Manchuan Chen; Yves LOBET; F R Matuschka; R B Kimsey; Fred S Kantor; Stephen W Barthold; Andrew Spielman; Richard A Flavell
Vaccination against Lyme disease caused by diverse Borrelia burgdorferi.
The Journal of experimental medicine 1995;181(1):215-21.
1994: L Huang; G Soldevila; M Leeker; Richard A Flavell; I Nicholas Crispe
The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo.
Immunity 1994;1(9):741-9.
1994: B F DiCosmo; D Picarella; Richard A Flavell
Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice.
International immunology 1994;6(12):1829-37.
1994: B F DiCosmo; Gregory P Geba; D Picarella; Jack A Elias; J A Rankin; B R Stripp; Jeffrey A Whitsett; Richard A Flavell
Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.
The Journal of clinical investigation 1994;94(5):2028-35.
1994: E A Elliott; Richard A Flavell
Transgenic mice expressing constitutive levels of IL-2 in islet beta cells develop diabetes.
International immunology 1994;6(11):1629-37.
1994: Cheong-Hee Chang; J D Fontes; M Peterlin; Richard A Flavell
Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.
The Journal of experimental medicine 1994;180(4):1367-74.
1994: Mercedes Rincón; Richard A Flavell
AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.
The EMBO journal 1994;13(18):4370-81.
1994: J Xu; T M Foy; Jon D Laman; E A Elliott; J J Dunn; Thomas J Waldschmidt; J Elsemore; Randolph J Noelle; Richard A Flavell
Mice deficient for the CD40 ligand.
Immunity 1994;1(5):423-31.
1994: S Guerder; D E Picarella; Peter Linsley; Richard A Flavell
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5138-42.
1994: T P Nguyen; T T Lam; Stephen W Barthold; S R Telford; Richard A Flavell; Erol Fikrig
Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice.
Infection and immunity 1994;62(5):2079-84.
1994: S Guerder; J Meyerhoff; Richard A Flavell
The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen.
Immunity 1994;1(2):155-66.
1994: Y M Law; R S Yeung; Clio Mamalaki; Dimitris Kioussis; T W Mak; Richard A Flavell
Human CD4 restores normal T cell development and function in mice deficient in murine CD4.
The Journal of experimental medicine 1994;179(4):1233-42.
1994: T T Lam; T P Nguyen; Erol Fikrig; Richard A Flavell
A chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease.
Journal of clinical microbiology 1994;32(4):876-83.
1994: Erol Fikrig; Linda K Bockenstedt; Stephen W Barthold; Manchuan Chen; H Tao; P Ali-Salaam; S R Telford; Richard A Flavell
Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis.
The Journal of infectious diseases 1994;169(3):568-74.
1994: J E Loh; Christian Schindler; Andrew Ziemiecki; A G Harpur; Andrew Wilks; Richard A Flavell
Mutant cell lines unresponsive to alpha/beta and gamma interferon are defective in tyrosine phosphorylation of ISGF-3 alpha components.
Molecular and cellular biology 1994;14(3):2170-9.
1994: E A Elliott; J R Drake; Sebastian Amigorena; J Elsemore; Paul Webster; Ira Mellman; Richard A Flavell
The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.
The Journal of experimental medicine 1994;179(2):681-94.
1994: Karen Roessner; E Fikrig; Jennifer Q Russell; S M Cooper; Richard A Flavell; Ralph C Budd
Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors.
European journal of immunology 1994;24(2):320-4.
1994: T T Lam; T P Nguyen; R R Montgomery; F S Kantor; Erol Fikrig; Richard A Flavell
Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease.
Infection and immunity 1994;62(1):290-8.
1993: T Geiger; G Soldevila; Richard A Flavell
T cells are responsive to the simian virus 40 large tumor antigen transgenically expressed in pancreatic islets.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):7030-7.
1993: D Levin; Stephanie L Constant; T Pasqualini; Richard A Flavell; Kim Bottomly
Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6742-50.
1993: Y Kamogawa; L A Minasi; Simon R Carding; Kim Bottomly; Richard A Flavell
The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells.
Cell 1993;75(5):985-95.
1993: Robert J Homer; Clio Mamalaki; Dimitris Kioussis; Richard A Flavell
T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model.
International immunology 1993;5(12):1495-500.
1993: Erol Fikrig; Louis A Magnarelli; Manchuan Chen; John F Anderson; Richard A Flavell
Serologic analysis of dogs, horses, and cottontail rabbits for antibodies to an antigenic flagellar epitope of Borrelia burgdorferi.
Journal of clinical microbiology 1993;31(9):2451-5.
1993: S R Telford; Erol Fikrig; Stephen W Barthold; L R Brunet; Andrew Spielman; Richard A Flavell
Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines.
The Journal of experimental medicine 1993;178(2):755-8.
1993: Linda K Bockenstedt; Erol Fikrig; Stephen W Barthold; Fred S Kantor; Richard A Flavell
Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):900-6.
1993: Erol Fikrig; Stephen W Barthold; Richard A Flavell
OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection.
Infection and immunity 1993;61(6):2553-7.
1993: Nancy H Ruddle; D Picarella; A Kratz; C B Li; Richard A Flavell
Probing the mechanism of TNF-alpha(cachectin)- and TNF-beta(lymphotoxin)-induced pancreatic inflammation with transgenic mice.
Research in immunology 1993;144(5):336-42.
1993: L E Minasi; Y Kamogawa; Simon R Carding; Kim Bottomly; Richard A Flavell
The selective ablation of interleukin 2-producing cells isolated from transgenic mice.
The Journal of experimental medicine 1993;177(5):1451-9.
1993: Erol Fikrig; H Tao; Fred S Kantor; Stephen W Barthold; Richard A Flavell
Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4092-6.
1993: D E Picarella; A Kratz; C B Li; Nancy H Ruddle; Richard A Flavell
Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):4136-50.
1993: Erol Fikrig; R Berland; Manchuan Chen; S Williams; Leonard Sigal; Richard A Flavell
Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):183-7.
1992: Louis A Magnarelli; Erol Fikrig; R Berland; John F Anderson; Richard A Flavell
Comparison of whole-cell antibodies and an antigenic flagellar epitope of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis.
Journal of clinical microbiology 1992;30(12):3158-62.
1992: Cheong-Hee Chang; W L Fodor; Richard A Flavell
Reactivation of a major histocompatibility complex class II gene in mouse plasmacytoma cells and mouse T cells.
The Journal of experimental medicine 1992;176(5):1465-9.
1992: D E Picarella; A Kratz; C B Li; Nancy H Ruddle; Richard A Flavell
Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10036-40.
1992: Erol Fikrig; S R Telford; Stephen W Barthold; Fred S Kantor; Andrew Spielman; Richard A Flavell
Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5418-21.
1992: Erol Fikrig; E D Huguenel; R Berland; Daniel W Rahn; John Hardin; Richard A Flavell
Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin.
The Journal of infectious diseases 1992;165(6):1127-32.
1992: Erol Fikrig; Stephen W Barthold; David H Persing; X Sun; Fred S Kantor; Richard A Flavell
Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2256-60.
1992: T Geiger; Linda R Gooding; Richard A Flavell
T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2985-9.
1992: J E Loh; Cheong-Hee Chang; W L Fodor; Richard A Flavell
Dissection of the interferon gamma-MHC class II signal transduction pathway reveals that type I and type II interferon systems share common signalling component(s).
The EMBO journal 1992;11(4):1351-63.
1992: Erol Fikrig; Stephen W Barthold; Fred S Kantor; Richard A Flavell
Long-term protection of mice from Lyme disease by vaccination with OspA.
Infection and immunity 1992;60(3):773-7.
1992: Mark de Souza; Erol Fikrig; AL Smith; Richard A Flavell; Stephen W Barthold
Nonspecific proliferative responses of murine lymphocytes to Borrelia burgdorferi antigens.
The Journal of infectious diseases 1992;165(3):471-8.
1992: Erol Fikrig; Stephen W Barthold; N Marcantonio; Kathleen DePonte; Fred S Kantor; Richard A Flavell
Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice.
Infection and immunity 1992;60(2):657-61.
1992: Cheong-Hee Chang; J Hammer; J E Loh; W L Fodor; Richard A Flavell
The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1).
Immunogenetics 1992;35(6):378-84.
1991: Erol Fikrig; Stephen W Barthold; Fred S Kantor; Richard A Flavell
Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA.
The Journal of infectious diseases 1991;164(6):1224-7.
1991: T Y Nakagawa; Hermann von Grafenstein; J E Sears; J Williams; Charles A Janeway; Richard A Flavell
The use of the polymerase chain reaction to map CD4+ T cell epitopes.
European journal of immunology 1991;21(11):2851-5.
1991: R Berland; Erol Fikrig; Daniel W Rahn; John Hardin; Richard A Flavell
Molecular characterization of the humoral response to the 41-kilodalton flagellar antigen of Borrelia burgdorferi, the Lyme disease agent.
Infection and immunity 1991;59(10):3531-5.
1991: J E Sears; Erol Fikrig; T Y Nakagawa; Kathleen DePonte; N Marcantonio; Fred S Kantor; Richard A Flavell
Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):1995-2000.
1991: B Su; G L Waneck; Richard A Flavell; Alfred L M Bothwell
The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E-mediated T cell activation.
The Journal of cell biology 1991;112(3):377-84.
1990: Erol Fikrig; Stephen W Barthold; Fred S Kantor; Richard A Flavell
Protection of mice against the Lyme disease agent by immunizing with recombinant OspA.
Science (New York, N.Y.) 1990;250(4980):553-6.
1989: D B Murphy; D Lo; S Rath; R L Brinster; Richard A Flavell; A Slanetz; Charles A Janeway
A novel MHC class II epitope expressed in thymic medulla but not cortex.
Nature 1989;338(6218):765-8.