Richard Flavell

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Jha Mithilesh K; Badou Abdallah; Meissner Marcel; McRory John E; Freichel Marc; Flockerzi Veit; Flavell Richard A
Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels.
Bai Fengwei; Town Terrence; Qian Feng; Wang Penghua; Kamanaka Masahito; Connolly Tarah M; Gate David; Montgomery Ruth R; Flavell Richard A; Fikrig Erol
IL-10 signaling blockade controls murine West Nile virus infection.
Marks Benjamin R; Nowyhed Heba N; Choi Jin-Young; Poholek Amanda C; Odegard Jared M; Flavell Richard A; Craft Joe
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.

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All Publications

2009: Jha Mithilesh K; Badou Abdallah; Meissner Marcel; McRory John E; Freichel Marc; Flockerzi Veit; Flavell Richard A
Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels.
Nature immunology 2009;10(12):1275-82.
2009: Bai Fengwei; Town Terrence; Qian Feng; Wang Penghua; Kamanaka Masahito; Connolly Tarah M; Gate David; Montgomery Ruth R; Flavell Richard A; Fikrig Erol
IL-10 signaling blockade controls murine West Nile virus infection.
PLoS pathogens 2009;5(10):e1000610.
2009: Marks Benjamin R; Nowyhed Heba N; Choi Jin-Young; Poholek Amanda C; Odegard Jared M; Flavell Richard A; Craft Joe
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.
Nature immunology 2009;10(10):1125-32.
2009: Qian Feng; Deng Jing; Cheng Ni; Welch Emily J; Zhang Yongliang; Malik Asrar B; Flavell Richard A; Dong Chen; Ye Richard D
A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury.
The EMBO journal 2009;28(19):2896-907.
2009: Wan Yisong Y; Flavell Richard A
How diverse--CD4 effector T cells and their functions.
Journal of molecular cell biology 2009;1(1):20-36.
2009: Kriegel Martin A; Rathinam Chozhavendan; Flavell Richard A
E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16770-5.
2009: Matza Didi; Flavell Richard A
Roles of Ca(v) channels and AHNAK1 in T cells: the beauty and the beast.
Immunological reviews 2009;231(1):257-64.
2009: Xiao Xiaoyan; Zhao Peng; Rodriguez-Pinto Daniel; Qi Dake; Henegariu Octavian; Alexopoulou Lena; Flavell Richard A; Wong F Susan; Wen Li
Inflammatory regulation by TLR3 in acute hepatitis.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3712-9.
2009: Standen Claire L; Kennedy Norman J; Flavell Richard A; Davis Roger J
Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
Molecular and cellular biology 2009;29(17):4831-40.
2009: Tiemi Shio Marina; Eisenbarth Stephanie C; Savaria Myriam; Vinet Adrien F; Bellemare Marie-Josée; Harder Kenneth W; Sutterwala Fayyaz S; Bohle D Scott; Descoteaux Albert; Flavell Richard A; Olivier Martin
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.
PLoS pathogens 2009;5(8):e1000559.
2009: Bruno Vincent M; Hannemann Sebastian; Lara-Tejero María; Flavell Richard A; Kleinstein Steven H; Galán Jorge E
Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells.
PLoS pathogens 2009;5(8):e1000538.
2009: Sanjabi Shomyseh; Zenewicz Lauren A; Kamanaka Masahito; Flavell Richard A
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.
Current opinion in pharmacology 2009;9(4):447-53.
2009: Sanjabi Shomyseh; Mosaheb Munir M; Flavell Richard A
Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells.
Immunity 2009;31(1):131-44.
2009: Di Paolo Nelson C; Miao Edward A; Iwakura Yoichiro; Murali-Krishna Kaja; Aderem Alan; Flavell Richard A; Papayannopoulou Thalia; Shayakhmetov Dmitry M
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
Immunity 2009;31(1):110-21.
2009: Kamanaka Masahito; Rainbow Dan; Schuster-Gossler Karin; Eynon Elizabeth E; Chervonsky Alexander V; Wicker Linda S; Flavell Richard A
Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11236-40.
2009: Ince M Nedim; Elliott David E; Setiawan Tommy; Metwali Ahmed; Blum Arthur; Chen Hung-lin; Urban Joseph F; Flavell Richard A; Weinstock Joel V
Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation.
European journal of immunology 2009;39(7):1870-8.
2009: Liu Guangwei; Burns Samir; Huang Gonghua; Boyd Kelli; Proia Richard L; Flavell Richard A; Chi Hongbo
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
Nature immunology 2009;10(7):769-77.
2009: Matza Didi; Badou Abdallah; Jha Mithilesh K; Willinger Tim; Antov Andrey; Sanjabi Shomyseh; Kobayashi Koichi S; Marchesi Vincent T; Flavell Richard A
Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9785-90.
2009: O'Connor William; Kamanaka Masahito; Booth Carmen J; Town Terrence; Nakae Susumu; Iwakura Yoichiro; Kolls Jay K; Flavell Richard A
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
Nature immunology 2009;10(6):603-9.
2009: Demento Stacey L; Eisenbarth Stephanie C; Foellmer Harald G; Platt Craig; Caplan Michael J; Mark Saltzman W; Mellman Ira; Ledizet Michel; Fikrig Erol; Flavell Richard A; Fahmy Tarek M
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy.
Vaccine 2009;27(23):3013-21.
2009: Lee Chun Geun; Hartl Dominik; Lee Gap Ryol; Koller Barbara; Matsuura Hiroshi; Da Silva Carla A; Sohn Myung Hyun; Cohn Lauren; Homer Robert J; Kozhich Alexander A; Humbles Alison; Kearley Jennifer; Coyle Anthony; Chupp Geoffrey; Reed Jennifer; Flavell Richard A; Elias Jack A
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.
The Journal of experimental medicine 2009;206(5):1149-66.
2009: Zenewicz Lauren A; Antov Andrey; Flavell Richard A
CD4 T-cell differentiation and inflammatory bowel disease.
Trends in molecular medicine 2009;15(5):199-207.
2009: Cone Robert E; Chattopadhyay Subhasis; Sharafieh Roshanak; Lemire Yen; O'Rourke James; Flavell Richard A; Clark Robert B
T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber.
International immunology 2009;21(5):567-74.
2009: Steenblock Erin R; Wrzesinski Stephen H; Flavell Richard A; Fahmy Tarek M
Antigen presentation on artificial acellular substrates: modular systems for flexible, adaptable immunotherapy.
Expert opinion on biological therapy 2009;9(4):451-64.
2009: Hartl Dominik; He Chuan Hua; Koller Babara; Da Silva Carla A; Kobayashi Yasushi; Lee Chun Geun; Flavell Richard A; Elias Jack A
Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):5098-106.
2009: Odegard Jared M; DiPlacido Leah D; Greenwald Lark; Kashgarian Michael; Kono Dwight H; Dong Chen; Flavell Richard A; Craft Joe
ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4076-84.
2009: Rosenzweig H L; Jann M M; Glant T T; Martin T M; Planck S R; van Eden W; van Kooten P J S; Flavell R A; Kobayashi K S; Rosenbaum J T; Davey M P
Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis.
Journal of leukocyte biology 2009;85(4):711-8.
2009: Ouyang Weiming; Beckett Omar; Flavell Richard A; Li Ming O
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance.
Immunity 2009;30(3):358-71.
2009: Moritoki Yuki; Zhang Weici; Tsuneyama Koichi; Yoshida Katsunori; Wakabayashi Kanji; Yang Guo-Xiang; Bowlus Christopher; Ridgway William M; Ueno Yoshiyuki; Ansari Aftab A; Coppel Ross L; Mackay Ian R; Flavell Richard A; Gershwin M Eric; Lian Zhe-Xiong
B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis.
Gastroenterology 2009;136(3):1037-47.
2009: Diebold S S; Schulz O; Alexopoulou L; Leitner W W; Flavell R A; Reis e Sousa C
Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines.
Gene therapy 2009;16(3):359-66.
2009: Town Terrence; Bai Fengwei; Wang Tian; Kaplan Amber T; Qian Feng; Montgomery Ruth R; Anderson John F; Flavell Richard A; Fikrig Erol
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing.
Immunity 2009;30(2):242-53.
2009: Lim A K H; Nikolic-Paterson D J; Ma F Y; Ozols E; Thomas M C; Flavell R A; Davis R J; Tesch G H
Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice.
Diabetologia 2009;52(2):347-58.
2009: Das Madhumita; Sabio Guadalupe; Jiang Feng; Rincón Mercedes; Flavell Richard A; Davis Roger J
Induction of hepatitis by JNK-mediated expression of TNF-alpha.
Cell 2009;136(2):249-60.
2009: Archer Kristina A; Alexopoulou Lena; Flavell Richard A; Roy Craig R
Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila.
Cellular microbiology 2009;11(1):21-36.
2009: Shilling Rebecca A; Clay Bryan S; Tesciuba Amanda G; Berry Elizabeth L; Lu Tiffany; Moore Tamson V; Bandukwala Hozefa S; Tong Jiankun; Weinstock Joel V; Flavell Richard A; Horan Tom; Yoshinaga Steve K; Welcher Andrew A; Cannon Judy L; Sperling Anne I
CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
Cellular immunology 2009;259(2):177-84.
2008: Wong F Susan; Hu Changyun; Zhang Li; Du Wei; Alexopoulou Lena; Flavell Richard A; Wen Li
The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice.
Annals of the New York Academy of Sciences 2008;1150():146-8.
2008: Zenewicz Lauren A; Flavell Richard A
IL-22 and inflammation: leukin' through a glass onion.
European journal of immunology 2008;38(12):3265-8.
2008: Murray Lynne A; Knight Darryl A; McAlonan Laura; Argentieri Rochelle; Joshi Amrita; Shaheen Furquan; Cunningham Mark; Alexopolou Lena; Flavell Richard A; Sarisky Robert T; Hogaboam Cory M
Deleterious role of TLR3 during hyperoxia-induced acute lung injury.
American journal of respiratory and critical care medicine 2008;178(12):1227-37.
2008: Shin Sunny; Case Christopher L; Archer Kristina A; Nogueira Catarina V; Kobayashi Koichi S; Flavell Richard A; Roy Craig R; Zamboni Dario S
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila.
PLoS pathogens 2008;4(11):e1000220.
2008: Odegard Jared M; Marks Benjamin R; DiPlacido Leah D; Poholek Amanda C; Kono Dwight H; Dong Chen; Flavell Richard A; Craft Joe
ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.
The Journal of experimental medicine 2008;205(12):2873-86.
2008: Divangahi Maziar; Mostowy Serge; Coulombe François; Kozak Robert; Guillot Loïc; Veyrier Frédéric; Kobayashi Koichi S; Flavell Richard A; Gros Philippe; Behr Marcel A
NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7157-65.
2008: Stephens Tracey A; Nikoopour Enayat; Rider Beverly J; Leon-Ponte Matilde; Chau Thu A; Mikolajczak Sebastian; Chaturvedi Pratibha; Lee-Chan Edwin; Flavell Richard A; Haeryfar S M Mansour; Madrenas Joaquin; Singh Bhagirath
Dendritic cell differentiation induced by a self-peptide derived from apolipoprotein E.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6859-71.
2008: Watanabe Chie; Shu Geraldine L; Zheng Timothy S; Flavell Richard A; Clark Edward A
Caspase 6 regulates B cell activation and differentiation into plasma cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6810-9.
2008: Rathinam Chozhavendan; Flavell Richard A
The hematopoiesis paradigm: clarity or ambiguity?
Blood 2008;112(9):3534-5.
2008: Wan Yisong Y; Flavell Richard A
TGF-beta and regulatory T cell in immunity and autoimmunity.
Journal of clinical immunology 2008;28(6):647-59.
2008: Brown Maile R; Kronengold Jack; Gazula Valeswara-Rao; Spilianakis Charalampos G; Flavell Richard A; von Hehn Christian A A; Bhattacharjee Arin; Kaczmarek Leonard K
Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation.
The Journal of physiology 2008;586(Pt 21):5161-79.
2008: Filippi Christophe M; Juedes Amy E; Oldham Janine E; Ling Ellie; Togher Lisa; Peng Yufeng; Flavell Richard A; von Herrath Matthias G
Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity.
Diabetes 2008;57(10):2684-92.
2008: Breunig Joshua J; Sarkisian Matthew R; Arellano Jon I; Morozov Yury M; Ayoub Albert E; Sojitra Sonal; Wang Baolin; Flavell Richard A; Rakic Pasko; Town Terrence
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):13127-32.
2008: Li Ming O; Flavell Richard A
TGF-beta: a master of all T cell trades.
Cell 2008;134(3):392-404.
2008: Laouar Yasmina; Town Terrence; Jeng David; Tran Elise; Wan Yisong; Kuchroo Vijay K; Flavell Richard A
TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10865-70.
2008: Wang Shuhui; Welte Thomas; McGargill Maureen; Town Terrence; Thompson Jesse; Anderson John F; Flavell Richard A; Fikrig Erol; Hedrick Stephen M; Wang Tian
Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2084-91.
2008: Czyzyk Jan; Chen Hui-Chen; Bottomly Kim; Flavell Richard A
p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells.
The Journal of biological chemistry 2008;283(34):23004-15.
2008: Rosenzweig H L; Martin T M; Planck S R; Galster K; Jann M M; Davey M P; Kobayashi K; Flavell R A; Rosenbaum J T
Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling.
Journal of leukocyte biology 2008;84(2):529-36.
2008: Cassel Suzanne L; Eisenbarth Stephanie C; Iyer Shankar S; Sadler Jeffrey J; Colegio Oscar R; Tephly Linda A; Carter A Brent; Rothman Paul B; Flavell Richard A; Sutterwala Fayyaz S
The Nalp3 inflammasome is essential for the development of silicosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9035-40.
2008: Kim S V; Flavell R A
Myosin I: from yeast to human.
Cellular and molecular life sciences : CMLS 2008;65(14):2128-37.
2008: Cassel Suzanne L; Sutterwala Fayyaz S; Flavell Richard A
The tiny conductor: immune regulation via commensal organisms.
Cell host & microbe 2008;3(6):340-1.
2008: Fujita Jun; Crane Ana M; Souza Marlon K; Dejosez Marion; Kyba Michael; Flavell Richard A; Thomson James A; Zwaka Thomas P
Caspase activity mediates the differentiation of embryonic stem cells.
Cell stem cell 2008;2(6):595-601.
2008: Town Terrence; Laouar Yasmina; Pittenger Christopher; Mori Takashi; Szekely Christine A; Tan Jun; Duman Ronald S; Flavell Richard A
Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
Nature medicine 2008;14(6):681-7.
2008: Eisenbarth Stephanie C; Colegio Oscar R; O'Connor William; Sutterwala Fayyaz S; Flavell Richard A
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.
Nature 2008;453(7198):1122-6.
2008: Lafon Monique; Mégret Françoise; Meuth Sven G; Simon Ole; Velandia Romero Myriam L; Lafage Mireille; Chen Lieping; Alexopoulou Lena; Flavell Richard A; Prehaud Christophe; Wiendl Heinz
Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7506-15.
2008: Singh Anurag; Carson William F; Secor Eric R; Guernsey Linda A; Flavell Richard A; Clark Robert B; Thrall Roger S; Schramm Craig M
Regulatory role of B cells in a murine model of allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7318-26.
2008: Yang Guo-Xiang; Lian Zhe-Xiong; Chuang Ya-Hui; Moritoki Yuki; Lan Ruth Y; Wakabayashi Kanji; Ansari Aftab A; Flavell Richard A; Ridgway William M; Coppel Ross L; Tsuneyama Koichi; Mackay Ian R; Gershwin M Eric
Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice.
Hepatology (Baltimore, Md.) 2008;47(6):1974-82.
2008: Hübner Anette; Barrett Tamera; Flavell Richard A; Davis Roger J
Multisite phosphorylation regulates Bim stability and apoptotic activity.
Molecular cell 2008;30(4):415-25.
2008: Pappu Bhanu P; Borodovsky Anna; Zheng Timothy S; Yang Xuexian; Wu Ping; Dong Xingwen; Weng Shawn; Browning Beth; Scott Martin L; Ma Li; Su Lihe; Tian Qiang; Schneider Pascal; Flavell Richard A; Dong Chen; Burkly Linda C
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease.
The Journal of experimental medicine 2008;205(5):1049-62.
2008: Fan Timothy M; Kranz David M; Flavell Richard A; Roy Edward J
Costimulatory strength influences the differential effects of transforming growth factor beta1 for the generation of CD8+ regulatory T cells.
Molecular immunology 2008;45(10):2937-50.
2008: Jacquet Sebastien; Nishino Yasuhiro; Kumphune Sarawut; Sicard Pierre; Clark James E; Kobayashi Koichi S; Flavell Richard A; Eickhoff Jan; Cotten Matt; Marber Michael S
The role of RIP2 in p38 MAPK activation in the stressed heart.
The Journal of biological chemistry 2008;283(18):11964-71.
2008: Reig Núria; Jiang Aimin; Couture Rachael; Sutterwala Fayyaz S; Ogura Yasunori; Flavell Richard A; Mellman Ira; van der Goot F Gisou
Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin.
Cellular microbiology 2008;10(5):1190-207.
2008: Rathinam Chozhavendan; Thien Christine B F; Langdon Wallace Y; Gu Hua; Flavell Richard A
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.
Genes & development 2008;22(8):992-7.
2008: Li Ming O; Flavell Richard A
Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10.
Immunity 2008;28(4):468-76.
2008: Rosenzweig Holly L; Martin Tammy M; Jann Monica M; Planck Stephen R; Davey Michael P; Kobayashi Koichi; Flavell Richard A; Rosenbaum James T
NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis.
Investigative ophthalmology & visual science 2008;49(4):1518-24.
2008: Mohanty Subhasis; Town Terrence; Yagi Tomohito; Scheidig Christina; Kwan Kelvin Y; Allore Heather G; Flavell Richard A; Shaw Albert C
Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5063-8.
2008: Williams Adam; Flavell Richard A
The role of CTCF in regulating nuclear organization.
The Journal of experimental medicine 2008;205(4):747-50.
2008: Rojo Jose M; Pini Eliana; Ojeda Gloria; Bello Raquel; Dong Chen; Flavell Richard A; Dianzani Umberto; Portolés Pilar
CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'.
International immunology 2008;20(4):577-89.
2008: Fukuda Kyoichi; Tesch Greg H; Yap Felicia Y; Forbes Josephine M; Flavell Richard A; Davis Roger J; Nikolic-Paterson David J
MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model.
Laboratory investigation; a journal of technical methods and pathology 2008;88(4):398-407.
2008: Ting Jenny P-Y; Lovering Ruth C; Alnemri Emad S; Bertin John; Boss Jeremy M; Davis Beckley K; Flavell Richard A; Girardin Stephen E; Godzik Adam; Harton Jonathan A; Hoffman Hal M; Hugot Jean-Pierre; Inohara Naohiro; Mackenzie Alex; Maltais Lois J; Nunez Gabriel; Ogura Yasunori; Otten Luc A; Philpott Dana; Reed John C; Reith Walter; Schreiber Stefan; Steimle Viktor; Ward Peter A
The NLR gene family: a standard nomenclature.
Immunity 2008;28(3):285-7.
2008: Kang Silvia S; Bloom Seth M; Norian Lyse A; Geske Michael J; Flavell Richard A; Stappenbeck Thaddeus S; Allen Paul M
An antibiotic-responsive mouse model of fulminant ulcerative colitis.
PLoS medicine 2008;5(3):e41.
2008: Hawiger Daniel; Tran Elise; Du Wei; Booth Carmen J; Wen Li; Dong Chen; Flavell Richard A
ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3140-7.
2008: Ou Rong; Zhang Menghua; Huang Lei; Flavell Richard A; Koni Pandelakis A; Moskophidis Demetrius
Regulation of immune response and inflammatory reactions against viral infection by VCAM-1.
Journal of virology 2008;82(6):2952-65.
2008: Couper Kevin N; Blount Daniel G; Wilson Mark S; Hafalla Julius C; Belkaid Yasmine; Kamanaka Masahito; Flavell Richard A; de Souza J Brian; Riley Eleanor M
IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.
PLoS pathogens 2008;4(2):e1000004.
2008: Town Terrence; Breunig Joshua J; Sarkisian Matthew R; Spilianakis Charalampos; Ayoub Albert E; Liu Xiuxin; Ferrandino Anthony F; Gallagher A Rachel; Li Ming O; Rakic Pasko; Flavell Richard A
The stumpy gene is required for mammalian ciliogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2853-8.
2008: Chuang Ya-Hui; Lian Zhe-Xiong; Yang Guo-Xiang; Shu Shang-An; Moritoki Yuki; Ridgway William M; Ansari Aftab A; Kronenberg Mitchell; Flavell Richard A; Gao Bin; Gershwin M Eric
Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2008;47(2):571-80.
2008: Sutterwala Fayyaz S; Flavell Richard A
Immunology: cascade into clarity.
Nature 2008;451(7176):254-5.
2008: Matza Didi; Badou Abdallah; Kobayashi Koichi S; Goldsmith-Pestana Karen; Masuda Yutaka; Komuro Akihiko; McMahon-Pratt Diane; Marchesi Vincent T; Flavell Richard A
A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation.
Immunity 2008;28(1):64-74.
2008: Hall Håkan T L; Wilhelm Margareta T; Saibil Samuel D; Mak Tak W; Flavell Richard A; Ohashi Pamela S
RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses.
European journal of immunology 2008;38(1):64-72.
2008: Pedra Joao H F; Mattner Jochen; Tao Jian; Kerfoot Steven M; Davis Roger J; Flavell Richard A; Askenase Philip W; Yin Zhinan; Fikrig Erol
c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.
Infection and immunity 2008;76(1):308-16.
2008: Chi Hongbo; Flavell Richard A
Acetylation of MKP-1 and the control of inflammation.
Science signaling 2008;1(41):pe44.
2008: Chi Hongbo; Flavell Richard A
Innate recognition of non-self nucleic acids.
Genome biology 2008;9(3):211.
2007: Sutterwala Fayyaz S; Mijares Lilia A; Li Li; Ogura Yasunori; Kazmierczak Barbara I; Flavell Richard A
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.
The Journal of experimental medicine 2007;204(13):3235-45.
2007: Awasthi Amit; Carrier Yijun; Peron Jean P S; Bettelli Estelle; Kamanaka Masahito; Flavell Richard A; Kuchroo Vijay K; Oukka Mohamed; Weiner Howard L
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.
Nature immunology 2007;8(12):1380-9.
2007: Wan Yisong Y; Flavell Richard A
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation.
Immunological reviews 2007;220():199-213.
2007: Deane Jonathan A; Pisitkun Prapaporn; Barrett Rebecca S; Feigenbaum Lionel; Town Terrence; Ward Jerrold M; Flavell Richard A; Bolland Silvia
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation.
Immunity 2007;27(5):801-10.
2007: Thomas Ian J; Petrich de Marquesini Liliana G; Ravanan Rommel; Smith Richard M; Guerder Sylvie; Flavell Richard A; Wraith David C; Wen Li; Wong F Susan
CD86 has sustained costimulatory effects on CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5936-46.
2007: Menon Suchithra; Chi Hongbo; Zhang Huiyong; Deng Xing Wang; Flavell Richard A; Wei Ning
COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
Nature immunology 2007;8(11):1236-45.
2007: Ma Frank Y; Tesch Greg H; Flavell Richard A; Davis Roger J; Nikolic-Paterson David J
MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney.
American journal of physiology. Renal physiology 2007;293(5):F1556-63.
2007: Kim Sean T; Fields Patrick E; Flavell Richard A
Demethylation of a specific hypersensitive site in the Th2 locus control region.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17052-7.
2007: Kaplan Daniel H; Li Ming O; Jenison Matthew C; Shlomchik Warren D; Flavell Richard A; Shlomchik Mark J
Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells.
The Journal of experimental medicine 2007;204(11):2545-52.
2007: Zenewicz Lauren A; Yancopoulos George D; Valenzuela David M; Murphy Andrew J; Karow Margaret; Flavell Richard A
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.
Immunity 2007;27(4):647-59.
2007: Das Madhumita; Jiang Feng; Sluss Hayla K; Zhang Chao; Shokat Kevan M; Flavell Richard A; Davis Roger J
Suppression of p53-dependent senescence by the JNK signal transduction pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15759-64.
2007: Wilson Mark S; Elnekave Eldad; Mentink-Kane Margaret M; Hodges Marcus G; Pesce John T; Ramalingam Thirumalai R; Thompson Robert W; Kamanaka Masahito; Flavell Richard A; Keane-Myers Andrea; Cheever Allen W; Wynn Thomas A
IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice.
The Journal of clinical investigation 2007;117(10):2941-51.
2007: Pedra Joao H F; Sutterwala Fayyaz S; Sukumaran Bindu; Ogura Yasunori; Qian Feng; Montgomery Ruth R; Flavell Richard A; Fikrig Erol
ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4783-91.
2007: Moh Akira; Iwamoto Yoshiki; Chai Gui-Xuan; Zhang Samual Shao-Min; Kano Arihiro; Yang Derek D; Zhang Wenjun; Wang Jun; Jacoby Joerg J; Gao Bin; Flavell Richard A; Fu Xin-Yuan
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery.
Laboratory investigation; a journal of technical methods and pathology 2007;87(10):1018-28.
2007: Willingham Stephen B; Bergstralh Daniel T; O'Connor William; Morrison Amy C; Taxman Debra J; Duncan Joseph A; Barnoy Shoshana; Venkatesan Malabi M; Flavell Richard A; Deshmukh Mohanish; Hoffman Hal M; Ting Jenny P-Y
Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.
Cell host & microbe 2007;2(3):147-59.
2007: Wrzesinski Stephen H; Wan Yisong Y; Flavell Richard A
Transforming growth factor-beta and the immune response: implications for anticancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 1):5262-70.
2007: Kennedy Norman J; Martin Gilles; Ehrhardt Anka G; Cavanagh-Kyros Julie; Kuan Chia-Yi; Rakic Pasko; Flavell Richard A; Treistman Steven N; Davis Roger J
Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.
Genes & development 2007;21(18):2336-46.
2007: Lim Jae Hyang; Stirling Brigid; Derry Jonathan; Koga Tomoaki; Jono Hirofumi; Woo Chang-Hoon; Xu Haodong; Bourne Patricia; Ha Un-Hwan; Ishinaga Hajime; Xu Haidong; Andalibi Ali; Feng Xin-Hua; Zhu Hongguang; Huang Yuxian; Zhang Wenhong; Weng Xinhua; Yan Chen; Yin Zhinan; Briles David E; Davis Roger J; Flavell Richard A; Li Jian-Dong
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.
Immunity 2007;27(2):349-60.
2007: Pedra Joao H F; Tao Jian; Sutterwala Fayyaz S; Sukumaran Bindu; Berliner Nancy; Bockenstedt Linda K; Flavell Richard A; Yin Zhinan; Fikrig Erol
IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis.
FEMS immunology and medical microbiology 2007;50(3):401-10.
2007: Sutterwala Fayyaz S; Ogura Yasunori; Flavell Richard A
The inflammasome in pathogen recognition and inflammation.
Journal of leukocyte biology 2007;82(2):259-64.
2007: Amsen Derk; Antov Andrey; Jankovic Dragana; Sher Alan; Radtke Freddy; Souabni Abdallah; Busslinger Meinrad; McCright Brent; Gridley Thomas; Flavell Richard A
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
Immunity 2007;27(1):89-99.
2007: Chi Hongbo; Flavell Richard A
Immunology: sensing the enemy within.
Nature 2007;448(7152):423-4.
2007: Wan Yisong Y; Flavell Richard A
Regulatory T cells, transforming growth factor-beta, and immune suppression.
Proceedings of the American Thoracic Society 2007;4(3):271-6.
2007: Tong Chang; Yin Zhinan; Song Zibo; Dockendorff Ashley; Huang Chuanshu; Mariadason John; Flavell Richard A; Davis Roger J; Augenlicht Leonard H; Yang Wancai
c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression.
The American journal of pathology 2007;171(1):297-303.
2007: Spilianakis Charalampos G; Flavell Richard A
Epigenetic regulation of Ifng expression.
Nature immunology 2007;8(7):681-3.
2007: Pan Qilin; Mathison John; Fearns Colleen; Kravchenko Vladimir V; Da Silva Correia Jean; Hoffman Hal M; Kobayashi Koichi S; Bertin John; Grant Ethan P; Coyle Anthony J; Sutterwala Fayyaz S; Ogura Yasunori; Flavell Richard A; Ulevitch Richard J
MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3.
Journal of leukocyte biology 2007;82(1):177-83.
2007: Henderson Neil C; Pollock Katharine J; Frew John; Mackinnon Alison C; Flavell Richard A; Davis Roger J; Sethi Tariq; Simpson Kenneth J
Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
Gut 2007;56(7):982-90.
2007: Clark James E; Flavell Richard A; Faircloth Matthew E; Davis Roger J; Heads Richard J; Marber Michael S
Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3).
Cardiovascular research 2007;74(3):466-70.
2007: Li Ming O; Wan Yisong Y; Flavell Richard A
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation.
Immunity 2007;26(5):579-91.
2007: Masud Ali; Mohapatra Alexander; Lakhani Saquib A; Ferrandino Anthony; Hakem Razqallah; Flavell Richard A
Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.
The Journal of biological chemistry 2007;282(19):14132-9.
2007: Pirianov Grisha; Brywe Katarina G; Mallard Carina; Edwards A David; Flavell Richard A; Hagberg Henrik; Mehmet Huseyin
Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(5):1022-32.
2007: Gowen Brian B; Wong Min-Hui; Jung Kie-Hoon; Sanders Andrew B; Mitchell William M; Alexopoulou Lena; Flavell Richard A; Sidwell Robert W
TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5200-8.
2007: Takai Y; Matikainen T; Jurisicova A; Kim M R; Trbovich A M; Fujita E; Nakagawa T; Lemmers B; Flavell R A; Hakem R; Momoi T; Yuan J; Tilly J L; Perez G I
Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells.
Apoptosis : an international journal on programmed cell death 2007;12(4):791-800.
2007: Chen Liang; He Weifeng; Kim Sean T; Tao Jian; Gao Yunfei; Chi Hongbo; Intlekofer Andrew M; Harvey Bohdan; Reiner Steven L; Yin Zhinan; Flavell Richard A; Craft Joe
Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):2730-6.
2007: Tao Jian; Gao Yunfei; Li Ming O; He Weifeng; Chen Liang; Harvev Bohdan; Davis Roger J; Flavell Richard A; Yin Zhinan
JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.
European journal of immunology 2007;37(3):818-29.
2007: Jankovic Dragana; Kullberg Marika C; Feng Carl G; Goldszmid Romina S; Collazo Carmen M; Wilson Mark; Wynn Thomas A; Kamanaka Masahito; Flavell Richard A; Sher Alan
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.
The Journal of experimental medicine 2007;204(2):273-83.
2007: Wan Yisong Y; Flavell Richard A
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression.
Nature 2007;445(7129):766-70.
2007: Bai Fengwei; Town Terrence; Pradhan Deepti; Cox Jonathan; Ashish; Ledizet Michel; Anderson John F; Flavell Richard A; Krueger Joanna K; Koski Raymond A; Fikrig Erol
Antiviral peptides targeting the west nile virus envelope protein.
Journal of virology 2007;81(4):2047-55.
2007: Brunelle Joslyn K; Shroff Emelyn H; Perlman Harris; Strasser Andreas; Moraes Carlos T; Flavell Richard A; Danial Nika N; Keith Brian; Thompson Craig B; Chandel Navdeep S
Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death.
Molecular and cellular biology 2007;27(4):1222-35.
2007: Temann Ulla-Angela; Laouar Yasmina; Eynon Elizabeth E; Homer Robert; Flavell Richard A
IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells.
International immunology 2007;19(1):1-10.
2007: Hardarson Hordur S; Baker J Scott; Yang Zhao; Purevjav Enkhsaikhan; Huang Chien-Hua; Alexopoulou Lena; Li Na; Flavell Richard A; Bowles Neil E; Vallejo Jesus G
Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury.
American journal of physiology. Heart and circulatory physiology 2007;292(1):H251-8.
2007: Fazzari Pietro; Penachioni Junia; Gianola Sara; Rossi Ferdinando; Eickholt Britta J; Maina Flavio; Alexopoulou Lena; Sottile Antonino; Comoglio Paolo Maria; Flavell Richard A; Tamagnone Luca
Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis.
BMC developmental biology 2007;7():55.
2006: Luo P; Reed B D; Tsang T C; Harris D T; Flavell R A
A self-augmenting gene expression cassette for enhanced and sustained transgene expression in the presence of proinflammatory cytokines.
DNA and cell biology 2006;25(12):659-67.
2006: Sarkisian Matthew R; Bartley Christopher M; Chi Hongbo; Nakamura Fumihiko; Hashimoto-Torii Kazue; Torii Masaaki; Flavell Richard A; Rakic Pasko
MEKK4 signaling regulates filamin expression and neuronal migration.
Neuron 2006;52(5):789-801.
2006: Kamanaka Masahito; Kim Sean T; Wan Yisong Y; Sutterwala Fayyaz S; Lara-Tejero Maria; Galán Jorge E; Harhaj Ed; Flavell Richard A
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse.
Immunity 2006;25(6):941-52.
2006: Girgenrath Mahasweta; Weng Shawn; Kostek Christine A; Browning Beth; Wang Monica; Brown Sharron A N; Winkles Jeffrey A; Michaelson Jennifer S; Allaire Norm; Schneider Pascal; Scott Martin L; Hsu Yen-ming; Yagita Hideo; Flavell Richard A; Miller Jeffrey Boone; Burkly Linda C; Zheng Timothy S
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration.
The EMBO journal 2006;25(24):5826-39.
2006: Gowen Brian B; Hoopes Justin D; Wong Min-Hui; Jung Kie-Hoon; Isakson Kevin C; Alexopoulou Lena; Flavell Richard A; Sidwell Robert W
TLR3 deletion limits mortality and disease severity due to Phlebovirus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6301-7.
2006: Veldhoen Marc; Hocking Richard J; Flavell Richard A; Stockinger Brigitta
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.
Nature immunology 2006;7(11):1151-6.
2006: Wang Ruibo; Town Terrence; Gokarn Varun; Flavell Richard A; Chandawarkar Rajiv Y
HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways.
The Journal of surgical research 2006;136(1):58-69.
2006: Badou Abdallah; Jha Mithilesh Kumar; Matza Didi; Mehal Wajahat Z; Freichel Marc; Flockerzi Veit; Flavell Richard A
Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15529-34.
2006: Kim Sangwon V; Mehal Wajahat Z; Dong Xuemei; Heinrich Volkmar; Pypaert Marc; Mellman Ira; Dembo Micah; Mooseker Mark S; Wu Dianqing; Flavell Richard A
Modulation of cell adhesion and motility in the immune system by Myo1f.
Science (New York, N.Y.) 2006;314(5796):136-9.
2006: Jaeschke Anja; Karasarides Maria; Ventura Juan-Jose; Ehrhardt Anka; Zhang Chao; Flavell Richard A; Shokat Kevan M; Davis Roger J
JNK2 is a positive regulator of the cJun transcription factor.
Molecular cell 2006;23(6):899-911.
2006: Christensen Sean R; Shupe Jonathan; Nickerson Kevin; Kashgarian Michael; Flavell Richard A; Shlomchik Mark J
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.
Immunity 2006;25(3):417-28.
2006: Li Ming O; Sanjabi Shomyseh; Flavell Richard A
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms.
Immunity 2006;25(3):455-71.
2006: Tran Elise H; Azuma Yasu-Taka; Chen Manchuan; Weston Claire; Davis Roger J; Flavell Richard A
Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(36):13451-6.
2006: Deng Jane C; Cheng Genhong; Newstead Michael W; Zeng Xianying; Kobayashi Koichi; Flavell Richard A; Standiford Theodore J
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M.
The Journal of clinical investigation 2006;116(9):2532-42.
2006: Abonia J Pablo; Hallgren Jenny; Jones Tatiana; Shi Tong; Xu Yuhui; Koni Pandelakis; Flavell Richard A; Boyce Joshua A; Austen K Frank; Gurish Michael F
Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung.
Blood 2006;108(5):1588-94.
2006: Ogura Yasunori; Sutterwala Fayyaz S; Flavell Richard A
The inflammasome: first line of the immune response to cell stress.
Cell 2006;126(4):659-62.
2006: Wan Yisong Y; Flavell Richard A
The roles for cytokines in the generation and maintenance of regulatory T cells.
Immunological reviews 2006;212():114-30.
2006: Feuillet Vincent; Medjane Samir; Mondor Isabelle; Demaria Olivier; Pagni Philippe P; Galán Jorge E; Flavell Richard A; Alexopoulou Lena
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12487-92.
2006: Bellahcene Mohamed; Jacquet Sebastien; Cao Xue B; Tanno Masaya; Haworth Robert S; Layland Joanne; Kabir Alamgir M; Gaestel Matthias; Davis Roger J; Flavell Richard A; Shah Ajay M; Avkiran Metin; Marber Michael S
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor.
Journal of the American College of Cardiology 2006;48(3):545-55.
2006: Oertelt Sabine; Lian Zhe-Xiong; Cheng Chun-Mei; Chuang Ya-Hui; Padgett Kerstien A; He Xiao-Song; Ridgway William M; Ansari Aftab A; Coppel Ross L; Li Ming O; Flavell Richard A; Kronenberg Mitchell; Mackay Ian R; Gershwin M Eric
Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1655-60.
2006: Wan Yisong Y; Chi Hongbo; Xie Min; Schneider Michael D; Flavell Richard A
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function.
Nature immunology 2006;7(8):851-8.
2006: Lara-Tejero Maria; Sutterwala Fayyaz S; Ogura Yasunori; Grant Ethan P; Bertin John; Coyle Anthony J; Flavell Richard A; Galán Jorge E
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.
The Journal of experimental medicine 2006;203(6):1407-12.
2006: Gitlin Leonid; Barchet Winfried; Gilfillan Susan; Cella Marina; Beutler Bruce; Flavell Richard A; Diamond Michael S; Colonna Marco
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8459-64.
2006: Du Wei; Wong F Susan; Li Ming O; Peng Jian; Qi Hao; Flavell Richard A; Sherwin Robert; Wen Li
TGF-beta signaling is required for the function of insulin-reactive T regulatory cells.
The Journal of clinical investigation 2006;116(5):1360-70.
2006: Ma Bing; Blackburn Michael R; Lee Chun Geun; Homer Robert J; Liu Wei; Flavell Richard A; Boyden Lynn; Lifton Richard P; Sun Chun-Xiao; Young Hays W; Elias Jack A
Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis.
The Journal of clinical investigation 2006;116(5):1274-83.
2006: Doran Beth; Gherbesi Norberto; Hendricks Gregory; Flavell Richard A; Davis Roger J; Gangwani Laxman
Deficiency of the zinc finger protein ZPR1 causes neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(19):7471-5.
2006: Lee Gap Ryol; Kim Sean T; Spilianakis Charalampos G; Fields Patrick E; Flavell Richard A
T helper cell differentiation: regulation by cis elements and epigenetics.
Immunity 2006;24(4):369-79.
2006: Spilianakis Charalampos G; Flavell Richard A
Molecular biology. Managing associations between different chromosomes.
Science (New York, N.Y.) 2006;312(5771):207-8.
2006: Kriegel Martin A; Li Ming O; Sanjabi Shomyseh; Wan Yisong Y; Flavell Richard A
Transforming growth factor-beta: recent advances on its role in immune tolerance.
Current rheumatology reports 2006;8(2):138-44.
2006: Inoue Tomoyuki; Boyle David L; Corr Maripat; Hammaker Deepa; Davis Roger J; Flavell Richard A; Firestein Gary S
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5484-9.
2006: Pan Qilin; Kravchenko Vladimir; Katz Alex; Huang Shuang; Ii Masayuki; Mathison John C; Kobayashi Koichi; Flavell Richard A; Schreiber Robert D; Goeddel David; Ulevitch Richard J
NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway.
Infection and immunity 2006;74(4):2121-7.
2006: Wu Wenfang; Misra Ravi S; Russell Jennifer Q; Flavell Richard A; Rincón Mercedes; Budd Ralph C
Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3.
The Journal of biological chemistry 2006;281(16):10682-90.
2006: Sutterwala Fayyaz S; Ogura Yasunori; Szczepanik Marian; Lara-Tejero Maria; Lichtenberger G Scott; Grant Ethan P; Bertin John; Coyle Anthony J; Galán Jorge E; Askenase Philip W; Flavell Richard A
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.
Immunity 2006;24(3):317-27.
2006: Town Terrence; Jeng David; Alexopoulou Lena; Tan Jun; Flavell Richard A
Microglia recognize double-stranded RNA via TLR3.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3804-12.
2006: Ventura Juan-Jose; Hübner Anette; Zhang Chao; Flavell Richard A; Shokat Kevan M; Davis Roger J
Chemical genetic analysis of the time course of signal transduction by JNK.
Molecular cell 2006;21(5):701-10.
2006: Zamboni Dario S; Kobayashi Koichi S; Kohlsdorf Tiana; Ogura Yasunori; Long E Michelle; Vance Russell E; Kuida Keisuke; Mariathasan Sanjeev; Dixit Vishva M; Flavell Richard A; Dietrich William F; Roy Craig R
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.
Nature immunology 2006;7(3):318-25.
2006: Mitchell Justin E; Cvetanovic Marija; Tibrewal Nitu; Patel Vimal; Colamonici Oscar R; Li Ming O; Flavell Richard A; Levine Jerrold S; Birge Raymond B; Ucker David S
The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells.
The Journal of biological chemistry 2006;281(9):5718-25.
2006: Lakhani Saquib A; Masud Ali; Kuida Keisuke; Porter George A; Booth Carmen J; Mehal Wajahat Z; Inayat Irteza; Flavell Richard A
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.
Science (New York, N.Y.) 2006;311(5762):847-51.
2006: Ait-Oufella Hafid; Salomon Benoît L; Potteaux Stéphane; Robertson Anna-Karin L; Gourdy Pierre; Zoll Joffrey; Merval Régine; Esposito Bruno; Cohen José L; Fisson Sylvain; Flavell Richard A; Hansson Göran K; Klatzmann David; Tedgui Alain; Mallat Ziad
Natural regulatory T cells control the development of atherosclerosis in mice.
Nature medicine 2006;12(2):178-80.
2006: Chi Hongbo; Barry Sean P; Roth Rachel J; Wu J Julie; Jones Elizabeth A; Bennett Anton M; Flavell Richard A
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2274-9.
2006: Rudd Brian D; Smit Jetse J; Flavell Richard A; Alexopoulou Lena; Schaller Matthew A; Gruber Achim; Berlin Aaron A; Lukacs Nicholas W
Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1937-42.
2006: Wohlfert Elizabeth A; Gorelik Leonid; Mittler Robert; Flavell Richard A; Clark Robert B
Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1316-20.
2006: Millet I; Wong F S; Gurr W; Wen L; Zawalich W; Green E A; Flavell R A; Sherwin R S
Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes.
Journal of autoimmunity 2006;26(1):7-15.
2006: al-Ramadi Basel K; Fernandez-Cabezudo Maria J; Ullah Azim; El-Hasasna Hussain; Flavell Richard A
CD154 is essential for protective immunity in experimental salmonella infection: evidence for a dual role in innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):496-506.
2006: Sutterwala Fayyaz S; Ogura Yasunori; Zamboni Dario S; Roy Craig R; Flavell Richard A
NALP3: a key player in caspase-1 activation.
Journal of endotoxin research 2006;12(4):251-6.
2006: Matalova Eva; Sharpe Paul T; Lakhani Saquib A; Roth Kevin A; Flavell Richard A; Setkova Jana; Misek Ivan; Tucker Abigail S
Molar tooth development in caspase-3 deficient mice.
The International journal of developmental biology 2006;50(5):491-7.
2006: Li Ming O; Wan Yisong Y; Sanjabi Shomyseh; Robertson Anna-Karin L; Flavell Richard A
Transforming growth factor-beta regulation of immune responses.
Annual review of immunology 2006;24():99-146.
2006: Peng Y; Gorelik L; Laouar Y; Li M O; Flavell R A
TGFbeta-mediated immunoregulation.
Ernst Schering Research Foundation workshop 2006;(56):155-60.
2005: Flavell Richard A; Kaczmarek Leonard K; Badou Abdallah; Boulpaep Emile L; Desai Rooma; Basavappa Srisaila; Matza Didi; Peng You-Qing; Mehal Wajahat Z
Retraction.
Science (New York, N.Y.) 2005;310(5756):1903.
2005: Spilianakis Charalampos G; Lee Gap Ryol; Flavell Richard A
Twisting the Th1/Th2 immune response via the retinoid X receptor: lessons from a genetic approach.
European journal of immunology 2005;35(12):3400-4.
2005: Jones Elizabeth A; Flavell Richard A
Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7437-46.
2005: Lau Christina M; Broughton Courtney; Tabor Abigail S; Akira Shizuo; Flavell Richard A; Mamula Mark J; Christensen Sean R; Shlomchik Mark J; Viglianti Gregory A; Rifkin Ian R; Marshak-Rothstein Ann
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.
The Journal of experimental medicine 2005;202(9):1171-7.
2005: Gao Yunfei; Tao Jian; Li Ming O; Zhang Dongqing; Chi Hongbo; Henegariu Octavian; Kaech Susan M; Davis Roger J; Flavell Richard A; Yin Zhinan
JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5783-9.
2005: Ijiri Kosei; Zerbini Luiz F; Peng Haibing; Correa Ricardo G; Lu Binfeng; Walsh Nicole; Zhao Yani; Taniguchi Noboru; Huang Xu-Ling; Otu Hasan; Wang Hong; Wang Jian Fei; Komiya Setsuro; Ducy Patricia; Rahman Mahboob U; Flavell Richard A; Gravallese Ellen M; Oettgen Peter; Libermann Towia A; Goldring Mary B
A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation.
The Journal of biological chemistry 2005;280(46):38544-55.
2005: Kabir Alamgir M N; Cao Xuebin; Gorog Diana A; Tanno Masaya; Bassi Rehka; Bellahcene Mohamed; Quinlan Roy A; Davis Roger J; Flavell Richard A; Shattock Michael J; Marber Michael S
Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3.
Journal of molecular and cellular cardiology 2005;39(4):709-17.
2005: Aoki Christopher A; Borchers Andrea T; Li Ming; Flavell Richard A; Bowlus Christopher L; Ansari Aftab A; Gershwin M Eric
Transforming growth factor beta (TGF-beta) and autoimmunity.
Autoimmunity reviews 2005;4(7):450-9.
2005: Zandy Anna J; Lakhani Saquib; Zheng Timothy; Flavell Richard A; Bassnett Steven
Role of the executioner caspases during lens development.
The Journal of biological chemistry 2005;280(34):30263-72.
2005: Christensen Sean R; Kashgarian Michael; Alexopoulou Lena; Flavell Richard A; Akira Shizuo; Shlomchik Mark J
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus.
The Journal of experimental medicine 2005;202(2):321-31.
2005: Eynon Elizabeth E; Zenewicz Lauren A; Flavell Richard A
Sugar-coated regulation of T cells.
Cell 2005;122(1):2-4.
2005: Shen Tang-Long; Park Ann Y-J; Alcaraz Ana; Peng Xu; Jang Ihnkyung; Koni Pandelakis; Flavell Richard A; Gu Hua; Guan Jun-Lin
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.
The Journal of cell biology 2005;169(6):941-52.
2005: Kimberly W Taylor; Zheng Jessica B; Town Terrence; Flavell Richard A; Selkoe Dennis J
Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5533-43.
2005: Zheng Tao; Kang Min Jong; Crothers Kristina; Zhu Zhou; Liu Wei; Lee Chun Geun; Rabach Lesley A; Chapman Harold A; Homer Robert J; Aldous David; De Sanctis George T; Underwood Stephen; Graupe Michael; Flavell Richard A; Schmidt John A; Elias Jack A
Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):8106-15.
2005: Spilianakis Charalampos G; Lalioti Maria D; Town Terrence; Lee Gap Ryol; Flavell Richard A
Interchromosomal associations between alternatively expressed loci.
Nature 2005;435(7042):637-45.
2005: Yarovinsky Felix; Zhang Dekai; Andersen John F; Bannenberg Gerard L; Serhan Charles N; Hayden Matthew S; Hieny Sara; Sutterwala Fayyaz S; Flavell Richard A; Ghosh Sankar; Sher Alan
TLR11 activation of dendritic cells by a protozoan profilin-like protein.
Science (New York, N.Y.) 2005;308(5728):1626-9.
2005: Laouar Yasmina; Sutterwala Fayyaz S; Gorelik Leonid; Flavell Richard A
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.
Nature immunology 2005;6(6):600-7.
2005: Abonia J Pablo; Austen K Frank; Rollins Barrett J; Joshi Sunil K; Flavell Richard A; Kuziel William A; Koni Pandelakis A; Gurish Michael F
Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2.
Blood 2005;105(11):4308-13.
2005: Jaeschke Anja; Rincón Mercedes; Doran Beth; Reilly Judith; Neuberg Donna; Greiner Dale L; Shultz Leonard D; Rossini Aldo A; Flavell Richard A; Davis Roger J
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6931-5.
2005: Brancho Deborah; Ventura Juan-Jose; Jaeschke Anja; Doran Beth; Flavell Richard A; Davis Roger J
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.
Molecular and cellular biology 2005;25(9):3670-81.
2005: Mehal Wajahat Z; Sheikh Shehzad Z; Gorelik Leonid; Flavell Richard A
TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions.
International immunology 2005;17(5):531-8.
2005: Li Hongmei; Cuartas Esteban; Cui Weiguo; Choi Yongwon; Crawford Todd D; Ke Hua Zhu; Kobayashi Koichi S; Flavell Richard A; Vignery Agnès
IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation.
The Journal of experimental medicine 2005;201(7):1169-77.
2005: Wan Yisong Y; Flavell Richard A
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5126-31.
2005: Kim Leesun; Del Rio Laura; Butcher Barbara A; Mogensen Trine H; Paludan Søren R; Flavell Richard A; Denkers Eric Y
p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):4178-84.
2005: Gangwani Laxman; Flavell Richard A; Davis Roger J
ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.
Molecular and cellular biology 2005;25(7):2744-56.
2005: Fahlén Linda; Read Simon; Gorelik Leonid; Hurst Stephen D; Coffman Robert L; Flavell Richard A; Powrie Fiona
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.
The Journal of experimental medicine 2005;201(5):737-46.
2005: Chi Hongbo; Sarkisian Matthew R; Rakic Pasko; Flavell Richard A
Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3846-51.
2005: Chi Hongbo; Flavell Richard A
Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2485-8.
2005: Townsend Kirk P; Town Terrence; Mori Takashi; Lue Lih-Fen; Shytle Doug; Sanberg Paul R; Morgan David; Fernandez Francisco; Flavell Richard A; Tan Jun
CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide.
European journal of immunology 2005;35(3):901-10.
2005: Kwon Hyokjoon; Jun Hee-Sook; Yang Yang; Mora Conchi; Mariathasan Sanjeev; Ohashi Pamela S; Flavell Richard A; Yoon Ji-Won
Development of autoreactive diabetogenic T cells in the thymus of NOD mice.
Journal of autoimmunity 2005;24(1):11-23.
2005: Schulz Oliver; Diebold Sandra S; Chen Margaret; Näslund Tanja I; Nolte Martijn A; Alexopoulou Lena; Azuma Yasu-Taka; Flavell Richard A; Liljeström Peter; Reis e Sousa Caetano
Toll-like receptor 3 promotes cross-priming to virus-infected cells.
Nature 2005;433(7028):887-92.
2005: Bynoe Margaret S; Viret Christophe; Flavell Richard A; Janeway Charles A
T cells from epicutaneously immunized mice are prone to T cell receptor revision.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2898-903.
2005: Kobayashi Koichi S; Chamaillard Mathias; Ogura Yasunori; Henegariu Octavian; Inohara Naohiro; Nuñez Gabriel; Flavell Richard A
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.
Science (New York, N.Y.) 2005;307(5710):731-4.
2005: Brecht Stephan; Kirchhof Rainer; Chromik Ansgar; Willesen Mette; Nicolaus Thomas; Raivich Gennadij; Wessig Jan; Waetzig Vicki; Goetz Mario; Claussen Malte; Pearse Damien; Kuan Chia-Yi; Vaudano Elisabetha; Behrens Axel; Wagner Erwin; Flavell Richard A; Davis Roger J; Herdegen Thomas
Specific pathophysiological functions of JNK isoforms in the brain.
The European journal of neuroscience 2005;21(2):363-77.
2005: Badou Abdallah; Basavappa Srisaila; Desai Rooma; Peng You-Qing; Matza Didi; Mehal Wajahat Z; Kaczmarek Leonard K; Boulpaep Emile L; Flavell Richard A
Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions.
Science (New York, N.Y.) 2005;307(5706):117-21.
2005: Chen Mei-Ling; Pittet Mikaël J; Gorelik Leonid; Flavell Richard A; Weissleder Ralph; von Boehmer Harald; Khazaie Khashayarsha
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(2):419-24.
2005: Lee Gap Ryol; Spilianakis Charalampos G; Flavell Richard A
Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions.
Nature immunology 2005;6(1):42-8.
2005: Fernandez-Cabezudo Maria J; Ullah Azim; Flavell Richard A; Al-Ramadi Basel K
Evidence for the requirement for CD40-CD154 interactions in resistance to infections with attenuated Salmonella.
Journal of endotoxin research 2005;11(6):395-9.
2005: Town Terrence; Tan Jun; Flavell Richard A; Mullan Mike
T-cells in Alzheimer's disease.
Neuromolecular medicine 2005;7(3):255-64.
2004: Miura Masako; Chen Xiao-Dong; Allen Matthew R; Bi Yanming; Gronthos Stan; Seo Byoung-Moo; Lakhani Saquib; Flavell Richard A; Feng Xin-Hua; Robey Pamela Gehron; Young Marian; Shi Songtao
A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells.
The Journal of clinical investigation 2004;114(12):1704-13.
2004: Fields Patrick E; Lee Gap Ryol; Kim Sean T; Bartsevich Victor V; Flavell Richard A
Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region.
Immunity 2004;21(6):865-76.
2004: Wang Tian; Town Terrence; Alexopoulou Lena; Anderson John F; Fikrig Erol; Flavell Richard A
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis.
Nature medicine 2004;10(12):1366-73.
2004: López Carolina B; Moltedo Bruno; Alexopoulou Lena; Bonifaz Laura; Flavell Richard A; Moran Thomas M
TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6882-9.
2004: Ventura Juan-Jose; Cogswell Patricia; Flavell Richard A; Baldwin Albert S; Davis Roger J
JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species.
Genes & development 2004;18(23):2905-15.
2004: Kuan Chia-Yi; Schloemer Aryn J; Lu Aigang; Burns Kevin A; Weng Wei-Lan; Williams Michael T; Strauss Kenneth I; Vorhees Charles V; Flavell Richard A; Davis Roger J; Sharp Frank R; Rakic Pasko
Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(47):10763-72.
2004: Gao Yuhao; Qian Wei-Ping; Dark Kimberly; Toraldo Gianluca; Lin Angela S P; Guldberg Robert E; Flavell Richard A; Weitzmann M Neale; Pacifici Roberto
Estrogen prevents bone loss through transforming growth factor beta signaling in T cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(47):16618-23.
2004: Spilianakis Charalampos G; Flavell Richard A
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus.
Nature immunology 2004;5(10):1017-27.
2004: Weston Claire R; Wong Anthony; Hall J Perry; Goad Mary E P; Flavell Richard A; Davis Roger J
The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14114-9.
2004: Young Holly Y; Zucker Peter; Flavell Richard A; Jevnikar Anthony M; Singh Bhagirath
Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation.
Transplantation 2004;78(4):509-15.
2004: Zhang Yongliang; Blattman Joseph N; Kennedy Norman J; Duong Julie; Nguyen Thang; Wang Ying; Davis Roger J; Greenberg Philip D; Flavell Richard A; Dong Chen
Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5.
Nature 2004;430(7001):793-7.
2004: Lee Chun Geun; Cho Soo Jung; Kang Min Jong; Chapoval Svetlana P; Lee Patty J; Noble Paul W; Yehualaeshet Teshome; Lu Binfeng; Flavell Richard A; Milbrandt Jeffrey; Homer Robert J; Elias Jack A
Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.
The Journal of experimental medicine 2004;200(3):377-89.
2004: Scott Benjamin G; Yang Huan; Tüzün Erdem; Dong Chen; Flavell Richard A; Christadoss Premkumar
ICOS is essential for the development of experimental autoimmune myasthenia gravis.
Journal of neuroimmunology 2004;153(1-2):16-25.
2004: Lee Gap Ryol; Flavell Richard A
Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma.
International immunology 2004;16(8):1155-60.
2004: Ventura Juan-Jose; Kennedy Norman J; Flavell Richard A; Davis Roger J
JNK regulates autocrine expression of TGF-beta1.
Molecular cell 2004;15(2):269-78.
2004: Kulka Marianna; Alexopoulou Lena; Flavell Richard A; Metcalfe Dean D
Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3.
The Journal of allergy and clinical immunology 2004;114(1):174-82.
2004: Amsen Derk; Blander J Magarian; Lee Gap Ryol; Tanigaki Kenji; Honjo Tasuku; Flavell Richard A
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.
Cell 2004;117(4):515-26.
2004: Edelmann Kurt H; Richardson-Burns Sarah; Alexopoulou Lena; Tyler Kenneth L; Flavell Richard A; Oldstone Michael B A
Does Toll-like receptor 3 play a biological role in virus infections?
Virology 2004;322(2):231-8.
2004: Zare Fariba; Bokarewa Maria; Nenonen Nancy; Bergström Thomas; Alexopoulou Lena; Flavell Richard A; Tarkowski Andrej
Arthritogenic properties of double-stranded (viral) RNA.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5656-63.
2004: Behrens Georg M N; Li Ming; Davey Gayle M; Allison Janette; Flavell Richard A; Carbone Francis R; Heath William R
Helper requirements for generation of effector CTL to islet beta cell antigens.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(9):5420-6.
2004: Kim Sangwon V; Flavell Richard A
Immunology. CD8alphaalpha and T cell memory.
Science (New York, N.Y.) 2004;304(5670):529-30.
2004: Chi Hongbo; Lu Binfeng; Takekawa Mutsuhiro; Davis Roger J; Flavell Richard A
GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.
The EMBO journal 2004;23(7):1576-86.
2004: Lund Jennifer M; Alexopoulou Lena; Sato Ayuko; Karow Margaret; Adams Niels C; Gale Nicholas W; Iwasaki Akiko; Flavell Richard A
Recognition of single-stranded RNA viruses by Toll-like receptor 7.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5598-603.
2004: Peng Yufeng; Laouar Yasmina; Li Ming O; Green E Allison; Flavell Richard A
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4572-7.
2004: Komuro Akihiko; Masuda Yutaka; Kobayashi Koichi; Babbitt Roger; Gunel Murat; Flavell Richard A; Marchesi Vincent T
The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(12):4053-8.
2004: Fikrig Erol; Coyle Patricia K; Schutzer Steven E; Chen Manchuan; Deng Zhidian; Flavell Richard A
Preferential presence of decorin-binding protein B (BBA25) and BBA50 antibodies in cerebrospinal fluid of patients with neurologic Lyme disease.
Journal of clinical microbiology 2004;42(3):1243-6.
2004: Zhang Dekai; Zhang Guolong; Hayden Matthew S; Greenblatt Matthew B; Bussey Crystal; Flavell Richard A; Ghosh Sankar
A toll-like receptor that prevents infection by uropathogenic bacteria.
Science (New York, N.Y.) 2004;303(5663):1522-6.
2004: Tabeta Koichi; Georgel Philippe; Janssen Edith; Du Xin; Hoebe Kasper; Crozat Karine; Mudd Suzanne; Shamel Louis; Sovath Sosathya; Goode Jason; Alexopoulou Lena; Flavell Richard A; Beutler Bruce
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3516-21.
2004: Christen Urs; Darwiche Rima; Thomas Helen E; Wolfe Tom; Rodrigo Evelyn; Chervonsky Alexander; Flavell Richard A; von Herrath Matthias G
Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells.
Diabetes 2004;53(3):591-6.
2004: Xu Jianchao; Wang Peili; Li Yanyan; Li Guoyong; Kaczmarek Leonard K; Wu Yanling; Koni Pandelakis A; Flavell Richard A; Desir Gary V
The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3112-7.
2004: Lu Binfeng; Zagouras Panayiotis; Fischer James E; Lu Junfeng; Li Baiyong; Flavell Richard A
Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3023-8.
2004: Fikrig Erol; Pal Utpal; Chen Manchuan; Anderson John F; Flavell Richard A
OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis.
Infection and immunity 2004;72(3):1755-9.
2004: Kobayashi Koichi S; Flavell Richard A
Shielding the double-edged sword: negative regulation of the innate immune system.
Journal of leukocyte biology 2004;75(3):428-33.
2004: Laouar Yasmina; Crispe I Nicholas; Flavell Richard A
Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development.
Blood 2004;103(6):1985-94.
2004: Lichtenberger G Scott; Flavell Richard A; Alexopoulou Lena
Innate immunity and apoptosis in IBD.
Inflammatory bowel diseases 2004;10 Suppl 1():S58-62.
2004: Tsuji Noriko M; Tsutsui Hiroko; Seki Ekihiro; Kuida Keisuke; Okamura Haruki; Nakanishi Kenji; Flavell Richard A
Roles of caspase-1 in Listeria infection in mice.
International immunology 2004;16(2):335-43.
2004: Mora Conchi; Grewal Iqbal S; Wong F Susan; Flavell Richard A
Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice.
International immunology 2004;16(2):257-64.
2004: Pal Utpal; Yang Xiaofeng; Chen Manchuan; Bockenstedt Linda K; Anderson John F; Flavell Richard A; Norgard Michael V; Fikrig Erol
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands.
The Journal of clinical investigation 2004;113(2):220-30.
2004: Song Ruiping; Mahidhara Raja S; Zhou Zhihong; Hoffman Rosemary A; Seol Dai-Wu; Flavell Richard A; Billiar Timothy R; Otterbein Leo E; Choi Augustine M K
Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1220-6.
2004: Hunot Stéphane; Vila Miquel; Teismann Peter; Davis Roger J; Hirsch Etienne C; Przedborski Serge; Rakic Pasko; Flavell Richard A
JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):665-70.
2004: Lu Binfeng; Ferrandino Anthony F; Flavell Richard A
Gadd45beta is important for perpetuating cognate and inflammatory signals in T cells.
Nature immunology 2004;5(1):38-44.
2004: Zheng Wei-ping; Zhao Qian; Zhao Xinyan; Li Baiyong; Hubank Mike; Schatz David G; Flavell Richard A
Up-regulation of Hlx in immature Th cells induces IFN-gamma expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):114-22.
2003: Chen Xinguo; Smith James D; Shi Hong; Yang Derek D; Flavell Richard A; Wolin Sandra L
The Ro autoantigen binds misfolded U2 small nuclear RNAs and assists mammalian cell survival after UV irradiation.
Current biology : CB 2003;13(24):2206-11.
2003: Laouar Yasmina; Welte Thomas; Fu Xin-Yuan; Flavell Richard A
STAT3 is required for Flt3L-dependent dendritic cell differentiation.
Immunity 2003;19(6):903-12.
2003: Hernandez Lorraine D; Pypaert Marc; Flavell Richard A; Galán Jorge E
A Salmonella protein causes macrophage cell death by inducing autophagy.
The Journal of cell biology 2003;163(5):1123-31.
2003: Kuan Chia-Yi; Whitmarsh Alan J; Yang Derek D; Liao Guanghong; Schloemer Aryn J; Dong Chen; Bao Jue; Banasiak Kenneth J; Haddad Gabriel G; Flavell Richard A; Davis Roger J; Rakic Pasko
A critical role of neural-specific JNK3 for ischemic apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15184-9.
2003: Xiao Changchun; Shim Jae-hyuck; Klüppel Michael; Zhang Samuel Shao-Min; Dong Chen; Flavell Richard A; Fu Xin-Yuan; Wrana Jeffrey L; Hogan Brigid L M; Ghosh Sankar
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
Genes & development 2003;17(23):2933-49.
2003: Otterbein Leo E; Otterbein Sherrie L; Ifedigbo Emeka; Liu Fang; Morse Danielle E; Fearns Colleen; Ulevitch Richard J; Knickelbein Roy; Flavell Richard A; Choi Augustine M
MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury.
The American journal of pathology 2003;163(6):2555-63.
2003: Hoebe Kasper; Janssen Edith M; Kim Sung O; Alexopoulou Lena; Flavell Richard A; Han Jiahuai; Beutler Bruce
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways.
Nature immunology 2003;4(12):1223-9.
2003: Li Ming O; Sarkisian Matthew R; Mehal Wajahat Z; Rakic Pasko; Flavell Richard A
Phosphatidylserine receptor is required for clearance of apoptotic cells.
Science (New York, N.Y.) 2003;302(5650):1560-3.
2003: Kano Arihiro; Wolfgang Michael J; Gao Qian; Jacoby Joerg; Chai Gui-Xuan; Hansen William; Iwamoto Yoshiki; Pober Jordan S; Flavell Richard A; Fu Xin-Yuan
Endothelial cells require STAT3 for protection against endotoxin-induced inflammation.
The Journal of experimental medicine 2003;198(10):1517-25.
2003: D'Sa Cleta; Klocke Barbara J; Cecconi Francesco; Lindsten Tulia; Thompson Craig B; Korsmeyer Stanley J; Flavell Richard A; Roth Kevin A
Caspase regulation of genotoxin-induced neural precursor cell death.
Journal of neuroscience research 2003;74(3):435-45.
2003: Robertson Anna-Karin L; Rudling Mats; Zhou Xinghua; Gorelik Leonid; Flavell Richard A; Hansson Göran K
Disruption of TGF-beta signaling in T cells accelerates atherosclerosis.
The Journal of clinical investigation 2003;112(9):1342-50.
2003: Green E Allison; Gorelik Leonid; McGregor Catrin M; Tran Elise H; Flavell Richard A
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10878-83.
2003: Morse Danielle; Pischke Soeren E; Zhou Zhihong; Davis Roger J; Flavell Richard A; Loop Torsten; Otterbein Sherrie L; Otterbein Leo E; Choi Augustine M K
Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.
The Journal of biological chemistry 2003;278(39):36993-8.
2003: Chakrabarti Sabyasachi; Kobayashi Koichi S; Flavell Richard A; Marks Carolyn B; Miyake Katsuya; Liston David R; Fowler Kimberly T; Gorelick Fred S; Andrews Norma W
Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice.
The Journal of cell biology 2003;162(4):543-9.
2003: Kelkar Nyaya; Delmotte Marie-Helene; Weston Claire R; Barrett Tamera; Sheppard Barbara J; Flavell Richard A; Davis Roger J
Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9843-8.
2003: Brancho Deborah; Tanaka Nobuyuki; Jaeschke Anja; Ventura Juan-Jose; Kelkar Nyaya; Tanaka Yoshinori; Kyuuma Masanao; Takeshita Toshikazu; Flavell Richard A; Davis Roger J
Mechanism of p38 MAP kinase activation in vivo.
Genes & development 2003;17(16):1969-78.
2003: Tanno Masaya; Bassi Rekha; Gorog Diana A; Saurin Adrian T; Jiang Jie; Heads Richard J; Martin Jody L; Davis Roger J; Flavell Richard A; Marber Michael S
Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.
Circulation research 2003;93(3):254-61.
2003: Lee Gap Ryol; Fields Patrick E; Griffin Thomas J; Flavell Richard A
Regulation of the Th2 cytokine locus by a locus control region.
Immunity 2003;19(1):145-53.
2003: Kobayashi Koichi S; Eynon Elizabeth E; Flavell Richard A
Intracellular debugging.
Nature immunology 2003;4(7):652-4.
2003: Eshima Koji; Choi Yongwon; Flavell Richard A
CD154-CD40-independent up-regulation of B7-2 on splenic antigen-presenting cells and efficient T cell priming by staphylococcal enterotoxin A.
International immunology 2003;15(7):817-26.
2003: Morse Danielle; Otterbein Leo E; Watkins Simon; Alber Sean; Zhou Zhihong; Flavell Richard A; Davis Roger J; Choi Augustine M K
Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice.
American journal of physiology. Lung cellular and molecular physiology 2003;285(1):L250-7.
2003: Lamb Jennifer A; Ventura Juan-Jose; Hess Patricia; Flavell Richard A; Davis Roger J
JunD mediates survival signaling by the JNK signal transduction pathway.
Molecular cell 2003;11(6):1479-89.
2003: Nurieva Roza I; Duong Julie; Kishikawa Hiroko; Dianzani Umberto; Rojo Jose M; Ho I cheng; Flavell Richard A; Dong Chen
Transcriptional regulation of th2 differentiation by inducible costimulator.
Immunity 2003;18(6):801-11.
2003: Xue Dahai; Shi Hong; Smith James D; Chen Xinguo; Noe Dennis A; Cedervall Tommy; Yang Derek D; Eynon Elizabeth; Brash Douglas E; Kashgarian Michael; Flavell Richard A; Wolin Sandra L
A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7503-8.
2003: Lakhani Saquib; Flavell Richard A
Caspases and T lymphocytes: a flip of the coin?
Immunological reviews 2003;193():22-30.
2003: Zhang Xuchen; Shan Peiying; Alam Jawed; Davis Roger J; Flavell Richard A; Lee Patty J
Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury.
The Journal of biological chemistry 2003;278(24):22061-70.
2003: Weston Claire R; Wong Anthony; Hall J Perry; Goad Mary E P; Flavell Richard A; Davis Roger J
JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.
Genes & development 2003;17(10):1271-80.
2003: Skak Kresten; Guerder Sylvie; Picarella Dominic E; Brenden Nina; Flavell Richard A; Michelsen Birgitte K
TNF-alpha impairs peripheral tolerance towards beta-cells, and local costimulation by B7.1 enhances the effector function of diabetogenic T cells.
European journal of immunology 2003;33(5):1341-50.
2003: Ventura Juan-Jose; Kennedy Norman J; Lamb Jennifer A; Flavell Richard A; Davis Roger J
c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.
Molecular and cellular biology 2003;23(8):2871-82.
2003: Kennedy Norman J; Sluss Hayla K; Jones Stephen N; Bar-Sagi Dafna; Flavell Richard A; Davis Roger J
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.
Genes & development 2003;17(5):629-37.
2003: Blander J Magarian; Sant'Angelo Derek B; Metz Daniela; Kim Sang-Won; Flavell Richard A; Bottomly Kim; Janeway Charles A
A pool of central memory-like CD4 T cells contains effector memory precursors.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):2940-8.
2003: Nurieva Roza I; Treuting Piper; Duong Julie; Flavell Richard A; Dong Chen
Inducible costimulator is essential for collagen-induced arthritis.
The Journal of clinical investigation 2003;111(5):701-6.
2003: Eshima Koji; Mora Conchi; Wong F Susan; Green E Allison; Grewal Iqbal S; Flavell Richard A
A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse.
International immunology 2003;15(3):351-7.
2003: Zhang Xuchen; Shan Peiying; Sasidhar Madhu; Chupp Geoffrey L; Flavell Richard A; Choi Augustine M K; Lee Patty J
Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium.
American journal of respiratory cell and molecular biology 2003;28(3):305-15.
2003: Xu Jianchao; Koni Pandelakis A; Wang Peili; Li Guoyong; Kaczmarek Leonard; Wu Yanling; Li Yanyan; Flavell Richard A; Desir Gary V
The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight.
Human molecular genetics 2003;12(5):551-9.
2003: Carambula Silvia F; Pru James K; Lynch Maureen P; Matikainen Tiina; Gonçalves Paulo Bayard D; Flavell Richard A; Tilly Jonathan L; Rueda Bo R
Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice.
Reproductive biology and endocrinology : RB&E 2003;1():15.
2003: Welte Thomas; Zhang Samuel S M; Wang Tian; Zhang Zhiyuan; Hesslein David G T; Yin Zhinan; Kano Arihiro; Iwamoto Yoshiki; Li En; Craft Joseph E; Bothwell Alfred L M; Fikrig Erol; Koni Pandelakis A; Flavell Richard A; Fu Xin-Yuan
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1879-84.
2003: Rajagopalan Govindarajan; Kudva Yogish C; Flavell Richard A; David Chella S
Accelerated diabetes in rat insulin promoter-tumor necrosis factor-alpha transgenic nonobese diabetic mice lacking major histocompatibility class II molecules.
Diabetes 2003;52(2):342-7.
2003: Savinov Alexei Y; Tcherepanov Andrew; Green E Allison; Flavell Richard A; Chervonsky Alexander V
Contribution of Fas to diabetes development.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):628-32.
2003: Takai Yasushi; Canning Jacqueline; Perez Gloria I; Pru James K; Schlezinger Jennifer J; Sherr David H; Kolesnick Richard N; Yuan Junying; Flavell Richard A; Korsmeyer Stanley J; Tilly Jonathan L
Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo.
Endocrinology 2003;144(1):69-74.
2003: Zhang Xuchen; Shan Peiying; Otterbein Leo E; Alam Jawed; Flavell Richard A; Davis Roger J; Choi Augustine M K; Lee Patty J
Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.
The Journal of biological chemistry 2003;278(2):1248-58.
2002: Jyothi M Divya; Flavell Richard A; Geiger Terrence L
Targeting autoantigen-specific T cells and suppression of autoimmune encephalomyelitis with receptor-modified T lymphocytes.
Nature biotechnology 2002;20(12):1215-20.
2002: Tan Jun; Town Terrence; Crawford Fiona; Mori Takashi; DelleDonne Anthony; Crescentini Robert; Obregon Demian; Flavell Richard A; Mullan Michael J
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.
Nature neuroscience 2002;5(12):1288-93.
2002: Wang Lin; Ma Rui; Flavell Richard A; Choi Mary E
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells.
The Journal of biological chemistry 2002;277(49):47257-62.
2002: Horng Tiffany; Barton Gregory M; Flavell Richard A; Medzhitov Ruslan
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.
Nature 2002;420(6913):329-33.
2002: Le Dean A; Wu Yongqin; Huang Zhihong; Matsushita Kohji; Plesnila Nikolaus; Augustinack Jean C; Hyman Bradley T; Yuan Junying; Kuida Keisuke; Flavell Richard A; Moskowitz Michael A
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15188-93.
2002: Whittaker Laurie; Niu Naiqian; Temann U-Angela; Stoddard Amy; Flavell Richard A; Ray Anuradha; Homer Robert J; Cohn Lauren
Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9.
American journal of respiratory cell and molecular biology 2002;27(5):593-602.
2002: Hess Patricia; Pihan German; Sawyers Charles L; Flavell Richard A; Davis Roger J
Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.
Nature genetics 2002;32(1):201-5.
2002: Grewal Iqbal S; Grewal Kate D; Wong F Susan; Wang Hua; Picarella Dominic E; Janeway Charles A; Flavell Richard A
Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism.
Journal of autoimmunity 2002;19(1-2):9-22.
2002: Leonard Jeffrey R; Klocke Barbara J; D'Sa Cleta; Flavell Richard A; Roth Kevin A
Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice.
Journal of neuropathology and experimental neurology 2002;61(8):673-7.
2002: Tanaka Nobuyuki; Kamanaka Masahito; Enslen Hervé; Dong Chen; Wysk Mark; Davis Roger J; Flavell Richard A
Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis.
EMBO reports 2002;3(8):785-91.
2002: Nicolson Kirsty; Freland Sofia; Weir Catherine; Delahunt Brett; Flavell Richard A; Bäckström B Thomas
Induction of experimental autoimmune encephalomyelitis in the absence of c-Jun N-terminal kinase 2.
International immunology 2002;14(8):849-56.
2002: Alexopoulou Lena; Thomas Venetta; Schnare Markus; Lobet Yves; Anguita Juan; Schoen Robert T; Medzhitov Ruslan; Fikrig Erol; Flavell Richard A
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice.
Nature medicine 2002;8(8):878-84.
2002: Kobayashi Koichi; Hernandez Lorraine D; Galán Jorge E; Janeway Charles A; Medzhitov Ruslan; Flavell Richard A
IRAK-M is a negative regulator of Toll-like receptor signaling.
Cell 2002;110(2):191-202.
2002: Fields Patrick E; Kim Sean T; Flavell Richard A
Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):647-50.
2002: Lei Kui; Nimnual Anjaruwee; Zong Wei-Xing; Kennedy Norman J; Flavell Richard A; Thompson Craig B; Bar-Sagi Dafna; Davis Roger J
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.
Molecular and cellular biology 2002;22(13):4929-42.
2002: Anguita Juan; Barthold Stephen W; Persinski Rafal; Hedrick Michael N; Huy Christy A; Davis Roger J; Flavell Richard A; Fikrig Erol
Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6352-7.
2002: Gorelik Leonid; Constant Stephanie; Flavell Richard A
Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation.
The Journal of experimental medicine 2002;195(11):1499-505.
2002: Conze Dietrich; Krahl Troy; Kennedy Norman; Weiss Linda; Lumsden Joanne; Hess Patricia; Flavell Richard A; Le Gros Graham; Davis Roger J; Rincón Mercedes
c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation.
The Journal of experimental medicine 2002;195(7):811-23.
2002: Arbour Nathalie; Naniche Denise; Homann Dirk; Davis Roger J; Flavell Richard A; Oldstone Michael B A
c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.
The Journal of experimental medicine 2002;195(7):801-10.
2002: Carambula Silvia F; Matikainen Tiina; Lynch Maureen P; Flavell Richard A; Gonçalves Paulo B Dias; Tilly Jonathan L; Rueda Bo R
Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum.
Endocrinology 2002;143(4):1495-501.
2002: Kobayashi Koichi; Inohara Naohiro; Hernandez Lorraine D; Galán Jorge E; Núñez Gabriel; Janeway Charles A; Medzhitov Ruslan; Flavell Richard A
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.
Nature 2002;416(6877):194-9.
2002: Koedel Uwe; Winkler Frank; Angele Barbara; Fontana Adriano; Flavell Richard A; Pfister Hans-Walter
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice.
Annals of neurology 2002;51(3):319-29.
2002: She Qing-Bai; Chen Nanyue; Bode Ann M; Flavell Richard A; Dong Zigang
Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.
Cancer research 2002;62(5):1343-8.
2002: Flavell R A; Dong C; Davis R J
Signaling and cell death in lymphocytes.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(2):80-2.
2002: Green E Allison; Choi Yongwon; Flavell Richard A
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals.
Immunity 2002;16(2):183-91.
2002: Tan Jun; Town Terrence; Mori Takashi; Obregon Demian; Wu Yajuan; DelleDonne Anthony; Rojiani Amyn; Crawford Fiona; Flavell Richard A; Mullan Mike
CD40 is expressed and functional on neuronal cells.
The EMBO journal 2002;21(4):643-52.
2002: Topilski Ian; Harmelin Alon; Flavell Richard A; Levo Yoram; Shachar Idit
Preferential Th1 immune response in invariant chain-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1610-7.
2002: Li Xiaoyu; Bu Xia; Lu Binfeng; Avraham Hava; Flavell Richard A; Lim Bing
The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.
Molecular and cellular biology 2002;22(4):1158-71.
2002: Martínez-Barnetche Jesús; Madrid-Marina Vicente; Flavell Richard A; Moreno José
Does CD40 ligation induce B cell negative selection?
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1042-9.
2002: Gorelik Leonid; Flavell Richard A
Transforming growth factor-beta in T-cell biology.
Nature reviews. Immunology 2002;2(1):46-53.
2002: Temann Ulla-Angela; Ray Prabir; Flavell Richard A
Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology.
The Journal of clinical investigation 2002;109(1):29-39.
2002: Flavell R A
The relationship of inflammation and initiation of autoimmune disease: role of TNF super family members.
Current topics in microbiology and immunology 2002;266():1-9.
2002: Dong Chen; Davis Roger J; Flavell Richard A
MAP kinases in the immune response.
Annual review of immunology 2002;20():55-72.
2001: Maric M; Arunachalam B; Phan U T; Dong C; Garrett W S; Cannon K S; Alfonso C; Karlsson L; Flavell R A; Cresswell P
Defective antigen processing in GILT-free mice.
Science (New York, N.Y.) 2001;294(5545):1361-5.
2001: Sun H; Lu B; Li R Q; Flavell R A; Taneja R
Defective T cell activation and autoimmune disorder in Stra13-deficient mice.
Nature immunology 2001;2(11):1040-7.
2001: Alexopoulou L; Holt A C; Medzhitov R; Flavell R A
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
Nature 2001;413(6857):732-8.
2001: Gorelik L; Flavell R A
Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells.
Nature medicine 2001;7(10):1118-22.
2001: Zaidi A U; McDonough J S; Klocke B J; Latham C B; Korsmeyer S J; Flavell R A; Schmidt R E; Roth K A
Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent.
Journal of neuropathology and experimental neurology 2001;60(10):937-45.
2001: Yu H; Leitenberg D; Li B; Flavell R A
Deficiency of small GTPase Rac2 affects T cell activation.
The Journal of experimental medicine 2001;194(7):915-26.
2001: Whitmarsh A J; Kuan C Y; Kennedy N J; Kelkar N; Haydar T F; Mordes J P; Appel M; Rossini A A; Jones S N; Flavell R A; Rakic P; Davis R J
Requirement of the JIP1 scaffold protein for stress-induced JNK activation.
Genes & development 2001;15(18):2421-32.
2001: Pérez-Melgosa M; Ochs H D; Linsley P S; Laman J D; van Meurs M; Flavell R A; Ernst R K; Miller S I; Wilson C B
Carrier-mediated enhancement of cognate T cell help: the basis for enhanced immunogenicity of meningococcal outer membrane protein polysaccharide conjugate vaccine.
European journal of immunology 2001;31(8):2373-81.
2001: Wu H J; Venkataraman C; Estus S; Dong C; Davis R J; Flavell R A; Bondada S
Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1263-73.
2001: Dong C; Davis R J; Flavell R A
Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase.
Journal of clinical immunology 2001;21(4):253-7.
2001: Bruckner S R; Tammariello S P; Kuan C Y; Flavell R A; Rakic P; Estus S
JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons.
Journal of neurochemistry 2001;78(2):298-303.
2001: Christen U; Wolfe T; Möhrle U; Hughes A C; Rodrigo E; Green E A; Flavell R A; von Herrath M G
A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7023-32.
2001: Tournier C; Dong C; Turner T K; Jones S N; Flavell R A; Davis R J
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines.
Genes & development 2001;15(11):1419-26.
2001: Matikainen T; Perez G I; Zheng T S; Kluzak T R; Rueda B R; Flavell R A; Tilly J L
Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary.
Endocrinology 2001;142(6):2468-80.
2001: Lu B; Yu H; Chow C; Li B; Zheng W; Davis R J; Flavell R A
GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells.
Immunity 2001;14(5):583-90.
2001: Chen N; Nomura M; She Q B; Ma W Y; Bode A M; Wang L; Flavell R A; Dong Z
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice.
Cancer research 2001;61(10):3908-12.
2001: Hunot S; Flavell R A
Apoptosis. Death of a monopoly?
Science (New York, N.Y.) 2001;292(5518):865-6.
2001: Rincón M; Flavell R A; Davis R J
Signal transduction by MAP kinases in T lymphocytes.
Oncogene 2001;20(19):2490-7.
2001: Lee G R; Fields P E; Flavell R A
Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level.
Immunity 2001;14(4):447-59.
2001: Koni P A; Joshi S K; Temann U A; Olson D; Burkly L; Flavell R A
Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow.
The Journal of experimental medicine 2001;193(6):741-54.
2001: Dong C; Temann U A; Flavell R A
Cutting edge: critical role of inducible costimulator in germinal center reactions.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3659-62.
2001: Dong C; Juedes A E; Temann U A; Shresta S; Allison J P; Ruddle N H; Flavell R A
ICOS co-stimulatory receptor is essential for T-cell activation and function.
Nature 2001;409(6816):97-101.
2001: Zaidi A U; D'Sa-Eipper C; Brenner J; Kuida K; Zheng T S; Flavell R A; Rakic P; Roth K A
Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(1):169-75.
2001: D'Sa-Eipper C; Leonard J R; Putcha G; Zheng T S; Flavell R A; Rakic P; Kuida K; Roth K A
DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3.
Development (Cambridge, England) 2001;128(1):137-46.
2000: Voll R E; Jimi E; Phillips R J; Barber D F; Rincon M; Hayday A C; Flavell R A; Ghosh S
NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development.
Immunity 2000;13(5):677-89.
2000: Flaishon L; Hershkoviz R; Lantner F; Lider O; Alon R; Levo Y; Flavell R A; Shachar I
Autocrine secretion of interferon gamma negatively regulates homing of immature B cells.
The Journal of experimental medicine 2000;192(9):1381-8.
2000: Zheng T S; Hunot S; Kuida K; Momoi T; Srinivasan A; Nicholson D W; Lazebnik Y; Flavell R A
Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation.
Nature medicine 2000;6(11):1241-7.
2000: Gorelik L; Fields P E; Flavell R A
Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4773-7.
2000: Dong C; Flavell R A
Control of T helper cell differentiation--in search of master genes.
Science's STKE : signal transduction knowledge environment 2000;2000(49):pe1.
2000: Manuelidis L; Zaitsev I; Koni P; Lu Z Y; Flavell R A; Fritch W
Follicular dendritic cells and dissemination of Creutzfeldt-Jakob disease.
Journal of virology 2000;74(18):8614-22.
2000: Constant S L; Dong C; Yang D D; Wysk M; Davis R J; Flavell R A
JNK1 is required for T cell-mediated immunity against Leishmania major infection.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2671-6.
2000: Zhang F; Rincon M; Flavell R A; Aune T M
Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1762-70.
2000: Chow C W; Dong C; Flavell R A; Davis R J
c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1.
Molecular and cellular biology 2000;20(14):5227-34.
2000: Li B; Yu H; Zheng W; Voll R; Na S; Roberts A W; Williams D A; Davis R J; Ghosh S; Flavell R A
Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation.
Science (New York, N.Y.) 2000;288(5474):2219-22.
2000: Green E A; Flavell R A
The temporal importance of TNFalpha expression in the development of diabetes.
Immunity 2000;12(5):459-69.
2000: Dong C; Yang D D; Tournier C; Whitmarsh A J; Xu J; Davis R J; Flavell R A
JNK is required for effector T-cell function but not for T-cell activation.
Nature 2000;405(6782):91-4.
2000: Millet I; Phillips R J; Sherwin R S; Ghosh S; Voll R E; Flavell R A; Vignery A; Rincón M
Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide.
The Journal of biological chemistry 2000;275(20):15114-21.
2000: Fikrig E; Feng W; Barthold S W; Telford S R; Flavell R A
Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5344-51.
2000: Tournier C; Hess P; Yang D D; Xu J; Turner T K; Nimnual A; Bar-Sagi D; Jones S N; Flavell R A; Davis R J
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.
Science (New York, N.Y.) 2000;288(5467):870-4.
2000: Rincón M; Conze D; Weiss L; Diehl N L; Fortner K A; Yang D; Flavell R A; Enslen H; Whitmarsh A; Davis R J
Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?
Immunology and cell biology 2000;78(2):166-75.
2000: Selznick L A; Zheng T S; Flavell R A; Rakic P; Roth K A
Amyloid beta-induced neuronal death is bax-dependent but caspase-independent.
Journal of neuropathology and experimental neurology 2000;59(4):271-9.
2000: Otterbein L E; Bach F H; Alam J; Soares M; Tao Lu H; Wysk M; Davis R J; Flavell R A; Choi A M
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway.
Nature medicine 2000;6(4):422-8.
2000: Pierre P; Shachar I; Matza D; Gatti E; Flavell R A; Mellman I
Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells.
The Journal of experimental medicine 2000;191(6):1057-62.
2000: Bot A; Holz A; Christen U; Wolfe T; Temann A; Flavell R; von Herrath M
Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses.
Virology 2000;269(1):66-77.
2000: Gorelik L; Flavell R A
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease.
Immunity 2000;12(2):171-81.
2000: Diehl N L; Enslen H; Fortner K A; Merritt C; Stetson N; Charland C; Flavell R A; Davis R J; Rincón M
Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo.
The Journal of experimental medicine 2000;191(2):321-34.
2000: Green E A; Wong F S; Eshima K; Mora C; Flavell R A
Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells.
The Journal of experimental medicine 2000;191(2):225-38.
2000: Weiss L; Whitmarsh A J; Yang D D; Rincón M; Davis R J; Flavell R A
Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation.
The Journal of experimental medicine 2000;191(1):139-46.
2000: Wen L; Wong F S; Tang J; Chen N Y; Altieri M; David C; Flavell R; Sherwin R
In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes.
The Journal of experimental medicine 2000;191(1):97-104.
2000: Roth K A; Kuan C; Haydar T F; D'Sa-Eipper C; Shindler K S; Zheng T S; Kuida K; Flavell R A; Rakic P
Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):466-71.
1999: Na S; Li B; Grewal I S; Enslen H; Davis R J; Hanke J H; Flavell R A
Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways.
Oncogene 1999;18(56):7966-74.
1999: Green E A; Flavell R A
The initiation of autoimmune diabetes.
Current opinion in immunology 1999;11(6):663-9.
1999: Cremona O; Di Paolo G; Wenk M R; Lüthi A; Kim W T; Takei K; Daniell L; Nemoto Y; Shears S B; Flavell R A; McCormick D A; De Camilli P
Essential role of phosphoinositide metabolism in synaptic vesicle recycling.
Cell 1999;99(2):179-88.
1999: Whitmire J K; Flavell R A; Grewal I S; Larsen C P; Pearson T C; Ahmed R
CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3194-201.
1999: Berger D P; Naniche D; Crowley M T; Koni P A; Flavell R A; Oldstone M B
Lymphotoxin-beta-deficient mice show defective antiviral immunity.
Virology 1999;260(1):136-47.
1999: Ballica R; Valentijn K; Khachatryan A; Guerder S; Kapadia S; Gundberg C; Gilligan J; Flavell R A; Vignery A
Targeted expression of calcitonin gene-related peptide to osteoblasts increases bone density in mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(7):1067-74.
1999: Green E A; Flavell R A
Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic mice.
Immunological reviews 1999;169():11-22.
1999: Eynon E E; Flavell R A
Walking through the forest of transgenic models of human disease.
Immunological reviews 1999;169():5-10.
1999: Geiger T L; Leitenberg D; Flavell R A
The TCR zeta-chain immunoreceptor tyrosine-based activation motifs are sufficient for the activation and differentiation of primary T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5931-9.
1999: Kuan C Y; Yang D D; Samanta Roy D R; Davis R J; Rakic P; Flavell R A
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development.
Neuron 1999;22(4):667-76.
1999: Lu H T; Yang D D; Wysk M; Gatti E; Mellman I; Davis R J; Flavell R A
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice.
The EMBO journal 1999;18(7):1845-57.
1999: Mora C; Wong F S; Chang C H; Flavell R A
Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4576-88.
1999: Green E A; Flavell R A
TRANCE-RANK, a new signal pathway involved in lymphocyte development and T cell activation.
The Journal of experimental medicine 1999;189(7):1017-20.
1999: Gourley T; Roys S; Lukacs N W; Kunkel S L; Flavell R A; Chang C H
A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production.
Immunity 1999;10(3):377-86.
1999: Wysk M; Yang D D; Lu H T; Flavell R A; Davis R J
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3763-8.
1999: Koni P A; Flavell R A
Lymph node germinal centers form in the absence of follicular dendritic cell networks.
The Journal of experimental medicine 1999;189(5):855-64.
1999: Eynon E E; Livák F; Kuida K; Schatz D G; Flavell R A
Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1448-59.
1999: Rincón M; Flavell R A
Reprogramming transcription during the differentiation of precursor CD4+ T cells into effector Th1 and Th2 cells.
Microbes and infection / Institut Pasteur 1999;1(1):43-50.
1999: Fikrig E; Chen M; Barthold S W; Anguita J; Feng W; Telford S R; Flavell R A
Borrelia burgdorferi erpT expression in the arthropod vector and murine host.
Molecular microbiology 1999;31(1):281-90.
1999: Li B; Tournier C; Davis R J; Flavell R A
Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.
The EMBO journal 1999;18(2):420-32.
1999: Flavell R A; Li B; Dong C; Lu H T; Yang D D; Enslen H; Tournier C; Whitmarsh A; Wysk M; Conze D; Rincon M; Davis R J
Molecular basis of T-cell differentiation.
Cold Spring Harbor symposia on quantitative biology 1999;64():563-71.
1999: Flavell R A
The molecular basis of T cell differentiation.
Immunologic research 1999;19(2-3):159-68.
1999: Janeway C A; Flavell R A
Immunology at Yale.
Immunologic research 1999;19(2-3):105-6.
1998: Dong C; Yang D D; Wysk M; Whitmarsh A J; Davis R J; Flavell R A
Defective T cell differentiation in the absence of Jnk1.
Science (New York, N.Y.) 1998;282(5396):2092-5.
1998: Zhang F; Wang D Z; Boothby M; Penix L; Flavell R A; Aune T M
Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6105-12.
1998: Green E A; Eynon E E; Flavell R A
Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens.
Immunity 1998;9(5):733-43.
1998: Rincón M; Whitmarsh A; Yang D D; Weiss L; Dérijard B; Jayaraj P; Davis R J; Flavell R A
The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes.
The Journal of experimental medicine 1998;188(10):1817-30.
1998: Zheng T S; Schlosser S F; Dao T; Hingorani R; Crispe I N; Boyer J L; Flavell R A
Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13618-23.
1998: Anguita J; Rincón M; Samanta S; Barthold S W; Flavell R A; Fikrig E
Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis.
The Journal of infectious diseases 1998;178(5):1512-5.
1998: Yang D D; Conze D; Whitmarsh A J; Barrett T; Davis R J; Rincón M; Flavell R A
Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.
Immunity 1998;9(4):575-85.
1998: Fikrig E; Feng W; Aversa J; Schoen R T; Flavell R A
Differential expression of Borrelia burgdorferi genes during erythema migrans and Lyme arthritis.
The Journal of infectious diseases 1998;178(4):1198-201.
1998: Temann U A; Geba G P; Rankin J A; Flavell R A
Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness.
The Journal of experimental medicine 1998;188(7):1307-20.
1998: Flavell R A; Rincón M; Zheng W P; Li B; Enslen H; Raingeaud J; Davis R J
The regulation of CD4 T cell differentiation.
European cytokine network 1998;9(3 Suppl):26-32.
1998: Wen L; Wong F S; Burkly L; Altieri M; Mamalaki C; Kioussis D; Flavell R A; Sherwin R S
Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice.
The Journal of clinical investigation 1998;102(5):947-57.
1998: Guerder S; Eynon E E; Flavell R A
Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2128-40.
1998: Borrow P; Tough D F; Eto D; Tishon A; Grewal I S; Sprent J; Flavell R A; Oldstone M B
CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection.
Journal of virology 1998;72(9):7440-9.
1998: Geng L; Solimena M; Flavell R A; Sherwin R S; Hayday A C
Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10055-60.
1998: Wong F S; Visintin I; Wen L; Granata J; Flavell R; Janeway C A
The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice.
The Journal of experimental medicine 1998;187(12):1985-93.
1998: Koni P A; Flavell R A
A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin beta.
The Journal of experimental medicine 1998;187(12):1977-83.
1998: Rincón M; Enslen H; Raingeaud J; Recht M; Zapton T; Su M S; Penix L A; Davis R J; Flavell R A
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway.
The EMBO journal 1998;17(10):2817-29.
1998: Grewal I S; Flavell R A
CD40 and CD154 in cell-mediated immunity.
Annual review of immunology 1998;16():111-35.
1997: Fikrig E; Barthold S W; Chen M; Chang C H; Flavell R A
Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5682-6.
1997: Lorico A; Rappa G; Finch R A; Yang D; Flavell R A; Sartorelli A C
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.
Cancer research 1997;57(23):5238-42.
1997: Rappa G; Lorico A; Flavell R A; Sartorelli A C
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.
Cancer research 1997;57(23):5232-7.
1997: Rincón M; Flavell R A
T-cell subsets: transcriptional control in the Th1/Th2 decision.
Current biology : CB 1997;7(11):R729-32.
1997: Ray P; Tang W; Wang P; Homer R; Kuhn C; Flavell R A; Elias J A
Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes.
The Journal of clinical investigation 1997;100(10):2501-11.
1997: Gu L; Rutledge B; Fiorillo J; Ernst C; Grewal I; Flavell R; Gladue R; Rollins B
In vivo properties of monocyte chemoattractant protein-1.
Journal of leukocyte biology 1997;62(5):577-80.
1997: Yang D D; Kuan C Y; Whitmarsh A J; Rincón M; Zheng T S; Davis R J; Rakic P; Flavell R A
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.
Nature 1997;389(6653):865-70.
1997: Chin Y E; Kitagawa M; Kuida K; Flavell R A; Fu X Y
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis.
Molecular and cellular biology 1997;17(9):5328-37.
1997: Grewal I S; Borrow P; Pamer E G; Oldstone M B; Flavell R A
The CD40-CD154 system in anti-infective host defense.
Current opinion in immunology 1997;9(4):491-7.
1997: Nogués N; Del Río J A; Pérez-Riba M; Soriano E; Flavell R A; Boronat A
Placenta-specific expression of the rat growth hormone-releasing hormone gene promoter in transgenic mice.
Endocrinology 1997;138(8):3222-7.
1997: Grewal I S; Rutledge B J; Fiorillo J A; Gu L; Gladue R P; Flavell R A; Rollins B J
Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):401-8.
1997: Aune T M; Flavell R A
Differential expression of transcription directed by a discrete NF-AT binding element from the IL-4 promoter in naive and effector CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):36-43.
1997: Soong L; Chang C H; Sun J; Longley B J; Ruddle N H; Flavell R A; McMahon-Pratt D
Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5374-83.
1997: Rincón M; Flavell R A
Regulation of the activity of the transcription factors AP-1 and NFAT during differentiation of precursor CD4+ T-cells into effector cells.
Biochemical Society transactions 1997;25(2):347-54.
1997: Fikrig E; Barthold S W; Sun W; Feng W; Telford S R; Flavell R A
Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity.
Immunity 1997;6(5):531-9.
1997: Zheng W; Flavell R A
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells.
Cell 1997;89(4):587-96.
1997: Huang C; Ma W Y; Dawson M I; Rincon M; Flavell R A; Dong Z
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5826-30.
1997: Koni P A; Sacca R; Lawton P; Browning J L; Ruddle N H; Flavell R A
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice.
Immunity 1997;6(4):491-500.
1997: Temann U A; Prasad B; Gallup M W; Basbaum C; Ho S B; Flavell R A; Rankin J A
A novel role for murine IL-4 in vivo: induction of MUC5AC gene expression and mucin hypersecretion.
American journal of respiratory cell and molecular biology 1997;16(4):471-8.
1997: Kuan C Y; Elliott E A; Flavell R A; Rakic P
Restrictive clonal allocation in the chimeric mouse brain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3374-9.
1997: Yang D; Tournier C; Wysk M; Lu H T; Xu J; Davis R J; Flavell R A
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3004-9.
1997: Chervonsky A V; Wang Y; Wong F S; Visintin I; Flavell R A; Janeway C A; Matis L A
The role of Fas in autoimmune diabetes.
Cell 1997;89(1):17-24.
1997: Fikrig E; Barthold S W; Chen M; Tao H; Ali-Salaam P; Bockenstedt L K; Flavell R A
Lyme borreliosis in transgenic mice tolerant to OspA from Borrelia burgdorferi 25015.
The Journal of infectious diseases 1997;175(4):1000-3.
1997: Nakamura T; Lee R K; Nam S Y; Podack E R; Bottomly K; Flavell R A
Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2648-53.
1997: Peng S L; McNiff J M; Madaio M P; Ma J; Owen M J; Flavell R A; Hayday A C; Craft J
alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2464-70.
1997: Nakamura T; Lee R K; Nam S Y; Al-Ramadi B K; Koni P A; Bottomly K; Podack E R; Flavell R A
Reciprocal regulation of CD30 expression on CD4+ T cells by IL-4 and IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2090-8.
1997: Rincón M; Flavell R A
Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells.
Molecular and cellular biology 1997;17(3):1522-34.
1997: Rincón M; Dérijard B; Chow C W; Davis R J; Flavell R A
Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells.
Genes and function 1997;1(1):51-68.
1997: Rincón M; Anguita J; Nakamura T; Fikrig E; Flavell R A
Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells.
The Journal of experimental medicine 1997;185(3):461-9.
1997: Grewal I S; Flavell R A
The CD40 ligand. At the center of the immune universe?
Immunologic research 1997;16(1):59-70.
1997: Khachatryan A; Guerder S; Palluault F; Cote G; Solimena M; Valentijn K; Millet I; Flavell R A; Vignery A
Targeted expression of the neuropeptide calcitonin gene-related peptide to beta cells prevents diabetes in NOD mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1409-16.
1997: Nakamura T; Kamogawa Y; Bottomly K; Flavell R A
Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1085-94.
1997: Grewal I S; Flavell R A
New insights into insulin dependent diabetes mellitus from studies with transgenic mouse models.
Laboratory investigation; a journal of technical methods and pathology 1997;76(1):3-10.
1997: Aune T M; Penix L A; Rincón M R; Flavell R A
Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CD8 T cells.
Molecular and cellular biology 1997;17(1):199-208.
1996: Tang W; Geba G P; Zheng T; Ray P; Homer R J; Kuhn C; Flavell R A; Elias J A
Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.
The Journal of clinical investigation 1996;98(12):2845-53.
1996: Lorico A; Rappa G; Flavell R A; Sartorelli A C
Double knockout of the MRP gene leads to increased drug sensitivity in vitro.
Cancer research 1996;56(23):5351-5.
1996: Bockenstedt L K; Fikrig E; Barthold S W; Flavell R A; Kantor F S
Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5496-502.
1996: Das S; Shraga D; Gannon C; Lam T T; Feng S; Brunet L R; Telford S R; Barthold S W; Flavell R A; Fikrig E
Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue.
Research in microbiology 1996;147(9):739-51.
1996: Kuida K; Zheng T S; Na S; Kuan C; Yang D; Karasuyama H; Rakic P; Flavell R A
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice.
Nature 1996;384(6607):368-72.
1996: Grewal I S; Grewal K D; Wong F S; Picarella D E; Janeway C A; Flavell R A
Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells.
The Journal of experimental medicine 1996;184(5):1963-74.
1996: Grewal I S; Flavell R A
The role of CD40 ligand in costimulation and T-cell activation.
Immunological reviews 1996;153():85-106.
1996: Shachar I; Flavell R A
Requirement for invariant chain in B cell maturation and function.
Science (New York, N.Y.) 1996;274(5284):106-8.
1996: Eynon E E; Kuida K; Flavell R A
Disruption of cytokine signaling in lymphoid development: unique contributions of the common cytokine gamma chain and the Jak3 kinase.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(9):677-84.
1996: Grewal I S; Flavell R A
A central role of CD40 ligand in the regulation of CD4+ T-cell responses.
Immunology today 1996;17(9):410-4.
1996: Cariappa A; Flyer D C; Rollins C T; Roopenian D C; Flavell R A; Brown D; Waneck G L
Glycosylphosphatidylinositol-anchored H-2Db molecules are defective in antigen processing and presentation to cytotoxic T lymphocytes.
European journal of immunology 1996;26(9):2215-24.
1996: Grewal I S; Foellmer H G; Grewal K D; Xu J; Hardardottir F; Baron J L; Janeway C A; Flavell R A
Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis.
Science (New York, N.Y.) 1996;273(5283):1864-7.
1996: Rankin J A; Picarella D E; Geba G P; Temann U A; Prasad B; DiCosmo B; Tarallo A; Stripp B; Whitsett J; Flavell R A
Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7821-5.
1996: Ma J; Xu J; Madaio M P; Peng Q; Zhang J; Grewal I S; Flavell R A; Craft J
Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):417-26.
1996: Fikrig E; Barthold S W; Chen M; Grewal I S; Craft J; Flavell R A
Protective antibodies in murine Lyme disease arise independently of CD40 ligand.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(1):1-3.
1996: Borrow P; Tishon A; Lee S; Xu J; Grewal I S; Oldstone M B; Flavell R A
CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.
The Journal of experimental medicine 1996;183(5):2129-42.
1996: Zhang J; Hagopian-Donaldson S; Serbedzija G; Elsemore J; Plehn-Dujowich D; McMahon A P; Flavell R A; Williams T
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2.
Nature 1996;381(6579):238-41.
1996: Anderson J F; Flavell R A; Magnarelli L A; Barthold S W; Kantor F S; Wallich R; Persing D H; Mathiesen D; Fikrig E
Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans.
Journal of clinical microbiology 1996;34(3):524-9.
1996: Soong L; Xu J C; Grewal I S; Kima P; Sun J; Longley B J; Ruddle N H; McMahon-Pratt D; Flavell R A
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection.
Immunity 1996;4(3):263-73.
1996: Rincon M; Flavell R A
Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells.
Molecular and cellular biology 1996;16(3):1074-84.
1996: Elias J A; Geba G P; Tang W; Schilz R; Zheng T; DiCosmo B; Flavell R A
Transgenic modeling of cytokines in the investigation of pulmonary disease.
Chest 1996;109(3 Suppl):69S-73S.
1996: Magnarelli L A; Fikrig E; Padula S J; Anderson J F; Flavell R A
Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of lyme borreliosis.
Journal of clinical microbiology 1996;34(2):237-40.
1996: Xu J; Grewal I S; Geba G P; Flavell R A
Impaired primary T cell responses in L-selectin-deficient mice.
The Journal of experimental medicine 1996;183(2):589-98.
1996: Wong F S; Visintin I; Wen L; Flavell R A; Janeway C A
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
The Journal of experimental medicine 1996;183(1):67-76.
1996: Flavell R A; Kratz A; Ruddle N H
The contribution of insulitis to diabetes development in tumor necrosis factor transgenic mice.
Current topics in microbiology and immunology 1996;206():33-50.
1995: von Herrath M G; Guerder S; Lewicki H; Flavell R A; Oldstone M B
Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes.
Immunity 1995;3(6):727-38.
1995: Grewal I S; Xu J; Flavell R A
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand.
Nature 1995;378(6557):617-20.
1995: Guerder S; Carding S R; Flavell R A
B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(11):5167-74.
1995: Fikrig E; Liu B; Fu L L; Das S; Smallwood J I; Flavell R A; Persing D H; Schoen R T; Barthold S W; Malawista S E
An ospA frame shift, identified from DNA in Lyme arthritis synovial fluid, results in an outer surface protein A that does not bind protective antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5700-4.
1995: Soldevila G; Geiger T; Flavell R A
Breaking immunologic ignorance to an antigenic peptide of simian virus 40 large T antigen.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(12):5590-600.
1995: Fikrig E; Tao H; Chen M; Barthold S W; Flavell R A
Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.
The Journal of clinical investigation 1995;96(4):1706-14.
1995: Jwang B; Dewing P; Fikrig E; Flavell R A
The hook protein of Borrelia burgdorferi, encoded by the flgE gene, is serologically recognized in Lyme disease.
Clinical and diagnostic laboratory immunology 1995;2(5):609-15.
1995: Feng S; Das S; Lam T; Flavell R A; Fikrig E
A 55-kilodalton antigen encoded by a gene on a Borrelia burgdorferi 49-kilobase plasmid is recognized by antibodies in sera from patients with Lyme disease.
Infection and immunity 1995;63(9):3459-66.
1995: Shachar I; Elliott E A; Chasnoff B; Grewal I S; Flavell R A
Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms.
Immunity 1995;3(3):373-83.
1995: Chang C H; Hong S C; Hughes C C; Janeway C A; Flavell R A
CIITA activates the expression of MHC class II genes in mouse T cells.
International immunology 1995;7(9):1515-8.
1995: Guerder S; Flavell R A
T-cell activation. Two for T.
Current biology : CB 1995;5(8):866-8.
1995: Magnarelli L A; Anderson J F; Flavell R A; Fikrig E
Reactivity of white-footed mouse and raccoon sera to whole cell and recombinant antigens of Borrelia burgdorferi.
Journal of wildlife diseases 1995;31(3):339-44.
1995: Cretella S; Gordon S; Flavell R A; Fikrig E
Evaluation of a Lyme disease enzyme immunoassay using the 41-G fragment of flagellin.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1995;14(7):609-13.
1995: Chervonsky A V; Xu J; Barlow A K; Khery M; Flavell R A; Janeway C A
Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV.
Immunity 1995;3(1):139-46.
1995: Antonia S J; Muñoz-Antonia T; Soldevila G; Miller J; Flavell R A
B7-1 expression by a non-antigen presenting cell-derived tumor.
Cancer research 1995;55(11):2253-6.
1995: Suk K; Das S; Sun W; Jwang B; Barthold S W; Flavell R A; Fikrig E
Borrelia burgdorferi genes selectively expressed in the infected host.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4269-73.
1995: Telford S R; Kantor F S; Lobet Y; Barthold S W; Spielman A; Flavell R A; Fikrig E
Efficacy of human Lyme disease vaccine formulations in a mouse model.
The Journal of infectious diseases 1995;171(5):1368-70.
1995: Constant S; Sant'Angelo D; Pasqualini T; Taylor T; Levin D; Flavell R; Bottomly K
Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):4915-23.
1995: Fikrig E; Tao H; Barthold S W; Flavell R A
Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B.
Infection and immunity 1995;63(5):1658-62.
1995: Antonia S J; Geiger T; Miller J; Flavell R A
Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein.
International immunology 1995;7(5):715-25.
1995: Dunne M; al-Ramadi B K; Barthold S W; Flavell R A; Fikrig E
Oral vaccination with an attenuated Salmonella typhimurium strain expressing Borrelia burgdorferi OspA prevents murine Lyme borreliosis.
Infection and immunity 1995;63(4):1611-4.
1995: DiCosmo B; Geba G; Picarella D; Elias J A; Rankin J A; Stripp B; Whitsett J A; Flavell R A
Expression of interleukin-6 by airway epithelial cells. Effects on airway inflammation and hyperreactivity in transgenic mice.
Chest 1995;107(3 Suppl):131S.
1995: Longley J; Ding T G; Levin D; Lewis J; Edelson R; Tigelaar R; Flavell R
Regulation of transgenic class II major histocompatibility genes in murine Langerhans cells.
The Journal of investigative dermatology 1995;104(3):329-34.
1995: Kuida K; Lippke J A; Ku G; Harding M W; Livingston D J; Su M S; Flavell R A
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
Science (New York, N.Y.) 1995;267(5206):2000-3.
1995: Wong S; Guerder S; Visintin I; Reich E P; Swenson K E; Flavell R A; Janeway C A
Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse.
Diabetes 1995;44(3):326-9.
1995: Chang C H; Flavell R A
Class II transactivator regulates the expression of multiple genes involved in antigen presentation.
The Journal of experimental medicine 1995;181(2):765-7.
1995: Fikrig E; Telford S R; Wallich R; Chen M; Lobet Y; Matuschka F R; Kimsey R B; Kantor F S; Barthold S W; Spielman A; Flavell R A
Vaccination against Lyme disease caused by diverse Borrelia burgdorferi.
The Journal of experimental medicine 1995;181(1):215-21.
1995: Guerder S; Flavell R A
Costimulation in tolerance and autoimmunity.
International reviews of immunology 1995;13(2):135-46.
1995: Nakamura T; Rincón M; Kamogawa Y; Flavell R A
Regulation of CD4+ T cell differentiation.
Ciba Foundation symposium 1995;195():154-68; discussion 168-72.
1994: Huang L; Soldevila G; Leeker M; Flavell R; Crispe I N
The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo.
Immunity 1994;1(9):741-9.
1994: DiCosmo B F; Picarella D; Flavell R A
Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice.
International immunology 1994;6(12):1829-37.
1994: DiCosmo B F; Geba G P; Picarella D; Elias J A; Rankin J A; Stripp B R; Whitsett J A; Flavell R A
Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.
The Journal of clinical investigation 1994;94(5):2028-35.
1994: Elliott E A; Flavell R A
Transgenic mice expressing constitutive levels of IL-2 in islet beta cells develop diabetes.
International immunology 1994;6(11):1629-37.
1994: Chang C H; Fontes J D; Peterlin M; Flavell R A
Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.
The Journal of experimental medicine 1994;180(4):1367-74.
1994: Rincón M; Flavell R A
AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.
The EMBO journal 1994;13(18):4370-81.
1994: Xu J; Foy T M; Laman J D; Elliott E A; Dunn J J; Waldschmidt T J; Elsemore J; Noelle R J; Flavell R A
Mice deficient for the CD40 ligand.
Immunity 1994;1(5):423-31.
1994: Nguyen T P; Lam T T; Barthold S W; Telford S R; Flavell R A; Fikrig E
Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice.
Infection and immunity 1994;62(5):2079-84.
1994: Guerder S; Meyerhoff J; Flavell R
The role of the T cell costimulator B7-1 in autoimmunity and the induction and maintenance of tolerance to peripheral antigen.
Immunity 1994;1(2):155-66.
1994: Guerder S; Picarella D E; Linsley P S; Flavell R A
Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5138-42.
1994: Law Y M; Yeung R S; Mamalaki C; Kioussis D; Mak T W; Flavell R A
Human CD4 restores normal T cell development and function in mice deficient in murine CD4.
The Journal of experimental medicine 1994;179(4):1233-42.
1994: Lam T T; Nguyen T P; Fikrig E; Flavell R A
A chromosomal Borrelia burgdorferi gene encodes a 22-kilodalton lipoprotein, P22, that is serologically recognized in Lyme disease.
Journal of clinical microbiology 1994;32(4):876-83.
1994: Fikrig E; Bockenstedt L K; Barthold S W; Chen M; Tao H; Ali-Salaam P; Telford S R; Flavell R A
Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis.
The Journal of infectious diseases 1994;169(3):568-74.
1994: Loh J E; Schindler C; Ziemiecki A; Harpur A G; Wilks A F; Flavell R A
Mutant cell lines unresponsive to alpha/beta and gamma interferon are defective in tyrosine phosphorylation of ISGF-3 alpha components.
Molecular and cellular biology 1994;14(3):2170-9.
1994: Elliott E A; Drake J R; Amigorena S; Elsemore J; Webster P; Mellman I; Flavell R A
The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.
The Journal of experimental medicine 1994;179(2):681-94.
1994: Roessner K; Fikrig E; Russell J Q; Cooper S M; Flavell R A; Budd R C
Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors.
European journal of immunology 1994;24(2):320-4.
1994: Lam T T; Nguyen T P; Montgomery R R; Kantor F S; Fikrig E; Flavell R A
Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease.
Infection and immunity 1994;62(1):290-8.
1993: Geiger T; Soldevila G; Flavell R A
T cells are responsive to the simian virus 40 large tumor antigen transgenically expressed in pancreatic islets.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):7030-7.
1993: Homer R J; Mamalaki C; Kioussis D; Flavell R A
T cell unresponsiveness correlates with quantitative TCR levels in a transgenic model.
International immunology 1993;5(12):1495-500.
1993: Levin D; Constant S; Pasqualini T; Flavell R; Bottomly K
Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6742-50.
1993: Kamogawa Y; Minasi L A; Carding S R; Bottomly K; Flavell R A
The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells.
Cell 1993;75(5):985-95.
1993: Fikrig E; Magnarelli L A; Chen M; Anderson J F; Flavell R A
Serologic analysis of dogs, horses, and cottontail rabbits for antibodies to an antigenic flagellar epitope of Borrelia burgdorferi.
Journal of clinical microbiology 1993;31(9):2451-5.
1993: Telford S R; Fikrig E; Barthold S W; Brunet L R; Spielman A; Flavell R A
Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines.
The Journal of experimental medicine 1993;178(2):755-8.
1993: Bockenstedt L K; Fikrig E; Barthold S W; Kantor F S; Flavell R A
Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):900-6.
1993: Fikrig E; Barthold S W; Flavell R A
OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection.
Infection and immunity 1993;61(6):2553-7.
1993: Ruddle N H; Picarella D; Kratz A; Li C B; Flavell R A
Probing the mechanism of TNF-alpha(cachectin)- and TNF-beta(lymphotoxin)-induced pancreatic inflammation with transgenic mice.
Research in immunology 1993;144(5):336-42.
1993: Minasi L E; Kamogawa Y; Carding S; Bottomly K; Flavell R A
The selective ablation of interleukin 2-producing cells isolated from transgenic mice.
The Journal of experimental medicine 1993;177(5):1451-9.
1993: Fikrig E; Tao H; Kantor F S; Barthold S W; Flavell R A
Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4092-6.
1993: Picarella D E; Kratz A; Li C B; Ruddle N H; Flavell R A
Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):4136-50.
1993: Fikrig E; Berland R; Chen M; Williams S; Sigal L H; Flavell R A
Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):183-7.
1992: Magnarelli L A; Fikrig E; Berland R; Anderson J F; Flavell R A
Comparison of whole-cell antibodies and an antigenic flagellar epitope of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis.
Journal of clinical microbiology 1992;30(12):3158-62.
1992: Chang C H; Fodor W L; Flavell R A
Reactivation of a major histocompatibility complex class II gene in mouse plasmacytoma cells and mouse T cells.
The Journal of experimental medicine 1992;176(5):1465-9.
1992: Picarella D E; Kratz A; Li C B; Ruddle N H; Flavell R A
Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10036-40.
1992: Fikrig E; Telford S R; Barthold S W; Kantor F S; Spielman A; Flavell R A
Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5418-21.
1992: Fikrig E; Huguenel E D; Berland R; Rahn D W; Hardin J A; Flavell R A
Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin.
The Journal of infectious diseases 1992;165(6):1127-32.
1992: Fikrig E; Barthold S W; Persing D H; Sun X; Kantor F S; Flavell R A
Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):2256-60.
1992: Geiger T; Gooding L R; Flavell R A
T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2985-9.
1992: Loh J E; Chang C H; Fodor W L; Flavell R A
Dissection of the interferon gamma-MHC class II signal transduction pathway reveals that type I and type II interferon systems share common signalling component(s).
The EMBO journal 1992;11(4):1351-63.
1992: Fikrig E; Barthold S W; Kantor F S; Flavell R A
Long-term protection of mice from Lyme disease by vaccination with OspA.
Infection and immunity 1992;60(3):773-7.
1992: de Souza M S; Fikrig E; Smith A L; Flavell R A; Barthold S W
Nonspecific proliferative responses of murine lymphocytes to Borrelia burgdorferi antigens.
The Journal of infectious diseases 1992;165(3):471-8.
1992: Fikrig E; Barthold S W; Marcantonio N; Deponte K; Kantor F S; Flavell R A
Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice.
Infection and immunity 1992;60(2):657-61.
1992: Chang C H; Hammer J; Loh J E; Fodor W L; Flavell R A
The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1).
Immunogenetics 1992;35(6):378-84.
1991: Fikrig E; Barthold S W; Kantor F S; Flavell R A
Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA.
The Journal of infectious diseases 1991;164(6):1224-7.
1991: Nakagawa T Y; Von Grafenstein H; Sears J E; Williams J; Janeway C A; Flavell R A
The use of the polymerase chain reaction to map CD4+ T cell epitopes.
European journal of immunology 1991;21(11):2851-5.
1991: Berland R; Fikrig E; Rahn D; Hardin J; Flavell R A
Molecular characterization of the humoral response to the 41-kilodalton flagellar antigen of Borrelia burgdorferi, the Lyme disease agent.
Infection and immunity 1991;59(10):3531-5.
1991: Sears J E; Fikrig E; Nakagawa T Y; Deponte K; Marcantonio N; Kantor F S; Flavell R A
Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):1995-2000.
1991: Su B; Waneck G L; Flavell R A; Bothwell A L
The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E-mediated T cell activation.
The Journal of cell biology 1991;112(3):377-84.
1990: Fikrig E; Barthold S W; Kantor F S; Flavell R A
Protection of mice against the Lyme disease agent by immunizing with recombinant OspA.
Science (New York, N.Y.) 1990;250(4980):553-6.
1989: Murphy D B; Lo D; Rath S; Brinster R L; Flavell R A; Slanetz A; Janeway C A
A novel MHC class II epitope expressed in thymic medulla but not cortex.
Nature 1989;338(6218):765-8.

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