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Jan Fleckner

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M-L F Hermansen; Lars Hornum; L Hummelshøj; Jan Fleckner; B Fox; P Keller; Dorthe Lundsgaard; L K Poulsen; Steffen Jacobsen
Increased serum β2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients.
Lotte Bjerre Knudsen; Christina Rye Underwood; Birgitte Schjellerup Wulff; Sven Hastrup; Jan Fleckner
Functional importance of GLP-1 receptor species and expression levels in cell lines.
Josine L Min; Matt J Neville; George Nicholson; Andreas Petri; Fredrik H Pettersson; Nigel W Rayner; Tim D Spector; Mary Travers; Quin F Wills; Maxine Allen; Kristian Almstrup; Amy Barrett; John Broxholme; Jane Cheeseman; Jan Fleckner; Ingileif Halgrimsdottir; Chris C Holmes; Fredrik Karpe; Cecilia M Lindgren; Reedik Mägi; Mark I McCarthy; Krina T Zondervan
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.

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All Publications

2012: M-L F Hermansen; Lars Hornum; L Hummelshøj; Jan Fleckner; B Fox; P Keller; Dorthe Lundsgaard; L K Poulsen; Steffen Jacobsen
Increased serum β2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients.
Lupus 2012;21(10):1098-104.
2012: Lotte Bjerre Knudsen; Christina Rye Underwood; Birgitte Schjellerup Wulff; Sven Hastrup; Jan Fleckner
Functional importance of GLP-1 receptor species and expression levels in cell lines.
Regulatory peptides 2012;175(1-3):21-9.
2012: Josine L Min; Matt J Neville; George Nicholson; Andreas Petri; Fredrik H Pettersson; Nigel W Rayner; Tim D Spector; Mary Travers; Quin F Wills; Maxine Allen; Kristian Almstrup; Amy Barrett; John Broxholme; Jane Cheeseman; Jan Fleckner; Ingileif Halgrimsdottir; Chris C Holmes; Fredrik Karpe; Cecilia M Lindgren; Reedik Mägi; Mark I McCarthy; Krina T Zondervan
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.
PLoS genetics 2012;8(2):e1002505.
2011: Mattias Rantalainen; Nigel W Rayner; Quin F Wills; Krina T Zondervan; Mark I McCarthy; Josine L Min; Matt J Neville; George Nicholson; Maxine Allen; Amy Barrett; Rory Bowden; Jan Fleckner; Blanca M Herrera; Chris C Holmes; Fredrik Karpe; Cecilia M Lindgren
MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven.
PloS one 2011;6(11):e27338.
2008: Philip J Larsen; Kirsten Lykkegaard; Leif K Larsen; Jan Fleckner; Per Sauerberg; Karsten Wassermann; Erik Max Wulff
Dissociation of antihyperglycaemic and adverse effects of partial perioxisome proliferator-activated receptor (PPAR-gamma) agonist balaglitazone.
European journal of pharmacology 2008;596(1-3):173-9.
2007: Tatjana Albrektsen; Brit Sorensen; G M Hjortø; Jan Fleckner; L Vijaya Mohan Rao; Lars C Petersen
Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells.
Journal of thrombosis and haemostasis : JTH 2007;5(8):1588-97.
2007: Per Sauerberg; John P Mogensen; Lone Jeppesen; Paul S Bury; Jan Fleckner; Grith S Olsen; Claus B Jeppesen; Erik M Wulff; Pavel Pihera; Miroslav Havranek; Zdenek Polivka; Ingrid Pettersson
Design of potent PPARalpha agonists.
Bioorganic & medicinal chemistry letters 2007;17(11):3198-202.
2007: Per Sauerberg; Grith S Olsen; Lone Jeppesen; John P Mogensen; Ingrid Pettersson; Claus B Jeppesen; Jens R Daugaard; Elisabeth D Galsgaard; Lars Ynddal; Jan Fleckner; Vladimira Panajotova; Zdenek Polivka; Pavel Pihera; Miroslav Havranek; Erik M Wulff
Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.
Journal of medicinal chemistry 2007;50(7):1495-503.
2006: Andreas Petri; Jonas Ahnfelt-Rønne; Klaus Stensgaard Frederiksen; David George Edwards; Dennis Madsen; Palle Serup; Jan Fleckner; R Scott Heller
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice.
Journal of molecular endocrinology 2006;37(2):301-16.
2006: Jae-Won Yang; Leila Afjehi-Sadat; Ellen Gelpi; Markus Kunze; Harald Höger; Jan Fleckner; Johannes Berger; Gert Lubec
Proteome profiling in the rat Harderian gland.
Journal of proteome research 2006;5(7):1751-62.
2006: Jan Nehlin; John P Mogensen; Ingrid Petterson; Lone Jeppesen; Jan Fleckner; Erik M Wulff; Per Sauerberg
Selective PPAR agonists for the treatment of type 2 diabetes.
Annals of the New York Academy of Sciences 2006;1067():448-53.
2005: Sophia G Moesgaard; Christian L Brand; Jeppe Sturis; Bo Ahrén; Michael Wilken; Jan Fleckner; Richard D Carr; Ove Svendsen; Anders J Hansen; Dorte X Gram
Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats.
American journal of physiology. Endocrinology and metabolism 2005;288(6):E1137-45.
2005: Per Sauerberg; John P Mogensen; Lone Jeppesen; L Anders Svensson; Jan Fleckner; Jan Nehlin; Erik M Wulff; Ingrid Pettersson
Structure-activity relationships of dimeric PPAR agonists.
Bioorganic & medicinal chemistry letters 2005;15(5):1497-500.
2005: Mads Wichmann Matthiessen; Gitte Pedersen; Tatjana Albrektsen; Sven Adamsen; Jan Fleckner; Jørn Brynskov
Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas.
Scandinavian journal of gastroenterology 2005;40(2):198-205.
2004: Mattias Hansson; Anna Tonning; Ulrik Frandsen; Andreas Petri; Jayaraj Rajagopal; Mikael Englund; R Scott Heller; Joakim Håkansson; Jan Fleckner; Helen Nilsson Sköld; Douglas Melton; Henrik Semb; Palle Serup
Artifactual insulin release from differentiated embryonic stem cells.
Diabetes 2004;53(10):2603-9.
2004: Maria Lajer; Lise Tarnow; Jan Fleckner; Birgitte V Hansen; D G Edwards; Hans-Henrik Parving; Esper Boel
Association of aldose reductase gene Z+2 polymorphism with reduced susceptibility to diabetic nephropathy in Caucasian Type 1 diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(8):867-73.
2004: Klaus Stensgaard Frederiksen; Erik M Wulff; Per Sauerberg; John P Mogensen; Lone Jeppesen; Jan Fleckner
Prediction of PPAR-alpha ligand-mediated physiological changes using gene expression profiles.
Journal of lipid research 2004;45(3):592-601.
2004: Andreas Petri; Jan Fleckner; Mads Wichmann Matthiessen
Array-A-Lizer: a serial DNA microarray quality analyzer.
BMC bioinformatics 2004;5():12.
2003: Per Sauerberg; Paul S Bury; John P Mogensen; Heinz-Josef Deussen; Ingrid Pettersson; Jan Fleckner; Jan Nehlin; Klaus S Frederiksen; Tatjana Albrektsen; Nanni Din; L Anders Svensson; Lars Ynddal; Erik M Wulff; Lone Jeppesen
Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo.
Journal of medicinal chemistry 2003;46(23):4883-94.
2003: Lise Madsen; Rasmus K Petersen; Morten B Sørensen; Claus Jørgensen; Philip Hallenborg; Lone Pridal; Jan Fleckner; Ez-Zoubir Amri; Peter Krieg; Gerhard Furstenberger; Rolf K Berge; Karsten Kristiansen
Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process.
The Biochemical journal 2003;375(Pt 3):539-49.
2003: Louise Torp Dalgaard; Gitte Andersen; Lesli H Larsen; Thorkild I A Sørensen; Teis Andersen; Thomas Drivsholm; Knut Borch-Johnsen; Jan Fleckner; Torben Hansen; Nanni Din; Oluf Pedersen
Mutational analysis of the UCP2 core promoter and relationships of variants with obesity.
Obesity research 2003;11(11):1420-7.
2003: Klaus Stensgaard Frederiksen; E M Wulf; Karsten Wassermann; Per Sauerberg; Jan Fleckner
Identification of hepatic transcriptional changes in insulin-resistant rats treated with peroxisome proliferator activated receptor-alpha agonists.
Journal of molecular endocrinology 2003;30(3):317-29.
2003: Søren Ebdrup; Ingrid Pettersson; Hanne B Rasmussen; Heinz-Josef Deussen; Anette Frost Jensen; Steen Mortensen; Jan Fleckner; Lone Pridal; Lars Nygaard; Per Sauerberg
Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.
Journal of medicinal chemistry 2003;46(8):1306-17.
2003: Christian L Brand; Jeppe Sturis; Carsten F Gotfredsen; Jan Fleckner; Christian Fledelius; Bo F Hansen; Birgitte Andersen; Ji-Ming Ye; Per Sauerberg; Karsten Wassermann
Dual PPARalpha /gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats.
American journal of physiology. Endocrinology and metabolism 2003;284(4):E841-54.
2003: John P Mogensen; Lone Jeppesen; Paul S Bury; Ingrid Pettersson; Jan Fleckner; Jan Nehlin; Klaus S Frederiksen; Tatjana Albrektsen; Nanni Din; Steen Mortensen; L Anders Svensson; Karsten Wassermann; Erik M Wulff; Lars Ynddal; Per Sauerberg
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.
Bioorganic & medicinal chemistry letters 2003;13(2):257-60.
2002: Torben Helledie; Lars Grøntved; Søren S Jensen; Pia Kiilerich; Luc Rietveld; Tatjana Albrektsen; Maria Sandberg Boysen; Jane Nøhr; Leif K Larsen; Jan Fleckner; Hendrik G Stunnenberg; Karsten Kristiansen; Susanne Mandrup
The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents.
The Journal of biological chemistry 2002;277(30):26821-30.
2002: Tatjana Albrektsen; Klaus Stensgaard Frederiksen; William E Holmes; Esper Boel; Karen Taylor; Jan Fleckner
Novel genes regulated by the insulin sensitizer rosiglitazone during adipocyte differentiation.
Diabetes 2002;51(4):1042-51.
2002: Per Sauerberg; Ingrid Pettersson; Lone Jeppesen; Paul S Bury; John P Mogensen; Karsten Wassermann; Christian L Brand; Jeppe Sturis; Helle F Wöldike; Jan Fleckner; Anne-Sofie T Andersen; Steen Mortensen; L Anders Svensson; Hanne B Rasmussen; Søren V Lehmann; Zdenek Polivka; Karel Sindelar; Vladimira Panajotova; Lars Ynddal; Erik M Wulff
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
Journal of medicinal chemistry 2002;45(4):789-804.
2001: Tatjana Albrektsen; H E Richter; J T Clausen; Jan Fleckner
Identification of a novel integral plasma membrane protein induced during adipocyte differentiation.
The Biochemical journal 2001;359(Pt 2):393-402.
2001: Tatjana Albrektsen; Jan Fleckner
The transcription factor Fos-related antigen 1 is induced by thiazolidinediones during differentiation of 3T3-L1 cells.
Molecular pharmacology 2001;59(3):567-75.
2000: Esper Boel; Tatjana Albrektsen; Jan Fleckner; J Selmer
Modulation of metabolism through transcriptional control has created new treatment opportunities for type 2 diabetes.
Current pharmaceutical biotechnology 2000;1(1):63-71.