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Bernd Fleischmann

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Indra Lübkemeier; Daniela Malan; Peter J Mohler; Stefan Offermanns; Robert Pascal Requardt; Philipp Sasse; Jan Schrickel; René Andrié; Feliksas F Bukauskas; Halina Chkourko; Mario Delmar; Radoslaw Dobrowolski; Bernd K Fleischmann; Marina Frank; Jung-Sun Kim; Xianming Lin; Angela Wirth; Jiong Zhang; Klaus Willecke
Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.
Daniela Malan; Sara A Wickström; Andrea Elischer; Bernd K Fleischmann; Michael Hesse; Wilhelm Bloch
Deletion of integrin linked kinase in endothelial cells results in defective RTK signaling caused by caveolin 1 mislocalization.
Leonie E Paulis; Wilhelm Roell; Katrin Zimmermann; Martin Breitbach; Bram F Coolen; Bernd K Fleischmann; Tessa Geelen; Alexander Ghanem; Alexandra M Klein; Klaas Nicolay; Gustav J Strijkers
Embryonic cardiomyocyte, but not autologous stem cell transplantation, restricts infarct expansion, enhances ventricular function, and improves long-term survival.

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All Publications

2013: Indra Lübkemeier; Daniela Malan; Peter J Mohler; Stefan Offermanns; Robert Pascal Requardt; Philipp Sasse; Jan Schrickel; René Andrié; Feliksas F Bukauskas; Halina Chkourko; Mario Delmar; Radoslaw Dobrowolski; Bernd K Fleischmann; Marina Frank; Jung-Sun Kim; Xianming Lin; Angela Wirth; Jiong Zhang; Klaus Willecke
Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.
Basic research in cardiology 2013;108(3):348.
2013: Daniela Malan; Sara A Wickström; Andrea Elischer; Bernd K Fleischmann; Michael Hesse; Wilhelm Bloch
Deletion of integrin linked kinase in endothelial cells results in defective RTK signaling caused by caveolin 1 mislocalization.
Development (Cambridge, England) 2013;140(5):987-95.
2013: Leonie E Paulis; Wilhelm Roell; Katrin Zimmermann; Martin Breitbach; Bram F Coolen; Bernd K Fleischmann; Tessa Geelen; Alexander Ghanem; Alexandra M Klein; Klaas Nicolay; Gustav J Strijkers
Embryonic cardiomyocyte, but not autologous stem cell transplantation, restricts infarct expansion, enhances ventricular function, and improves long-term survival.
PloS one 2013;8(4):e61510.
2013: Filomain Nguemo; Kurt Pfannkuche; Tomo Sarić; Heribert Schunkert; Wilhelm Bloch; Bernd K Fleischmann; Manoj K Gupta; Jürgen Hescheler; Huamin Liang; Daniela Malan; Michael Reppel
The L-type Ca2+ channels blocker nifedipine represses mesodermal fate determination in murine embryonic stem cells.
PloS one 2013;8(1):e53407.
2012: Martin Müller; Marianne Stockmann; Michael Tischendorf; Götz von Wichert; Maria Wartenberg; Anna M Wobus; Anne Wolheim; Martin Zenke; Tobias M Boeckers; Cornelia Brunner; Bernd K Fleischmann; Sarah-Fee Katz; Stephan Latz; Stefan Liebau; Qiong Lin; Leonhard Linta; Daniela Malan; Alexander Kleger
Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men.
Stem cell reviews 2012;8(3):720-40.
2012: Sophy A Jesty; Martin Breitbach; Robert Doran; Bernd K Fleischmann; Michael Hesse; Frank K Lee; Jane C Lee; Alexander Nikitin; Shaun Reining; Michele A Steffey; Michael I Kotlikoff
c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(33):13380-5.
2012: Daniela Malan; Bernd K Fleischmann
Functional expression and modulation of the L-type Ca2+ current in embryonic heart cells.
Pediatric cardiology 2012;33(6):907-15.
2012: Daniela Wenzel; Jan C Heinemann; Manuel Koch; Michaela Matthey; Bernd K Fleischmann
Identification of a novel vasoconstrictor peptide specific for the systemic circulation.
Hypertension 2012;59(6):1256-62.
2012: Christina Trueck; Sarah Vosen; Daniela Wenzel; Katrin Zimmermann; Martina Anton; Bernd K Fleischmann; Olga Mykhaylyk; Alexander Pfeifer
Optimization of magnetic nanoparticle-assisted lentiviral gene transfer.
Pharmaceutical research 2012;29(5):1255-69.
2012: Daniela Wenzel; Katrin Zimmermann; Dietmar Eberbeck; Olga Mykhaylyk; Alexander Pfeifer; Sarah Rieck; Lutz Trahms; Christina Trueck; Sarah Vosen; Bernd K Fleischmann
Identification of magnetic nanoparticles for combined positioning and lentiviral transduction of endothelial cells.
Pharmaceutical research 2012;29(5):1242-54.
2012: Carsten Kilgus; Annika Ottersbach; Wilhelm Roell; Bernd K Fleischmann; Bernhard Gleich; Alexandra Heidsieck; Christina Trueck; Philipp Sasse
Local gene targeting and cell positioning using magnetic nanoparticles and magnetic tips: comparison of mathematical simulations with experiments.
Pharmaceutical research 2012;29(5):1380-91.
2012: Jens M Kelm; Bernhard Odermatt; Irina Agarkova; Martin Breitbach; Gregor Fischer; Bernd K Fleischmann; Simon P Hoerstrup
3D microtissue formation of undifferentiated bone marrow mesenchymal stem cells leads to elevated apoptosis.
Tissue engineering. Part A 2012;18(7-8):692-702.
2012: Katia Herz; Michael Hesse; Annika Ottersbach; Wilhelm Röll; Bernd K Fleischmann; Christopher J Fuegemann; Caroline Geisen; Jan C Heinemann; Daniela Wenzel
Live monitoring of small vessels during development and disease using the flt-1 promoter element.
Basic research in cardiology 2012;107(2):257.
2012: Michael Hesse; Ronald Jabs; Alexandra M Klein; Michael I Kotlikoff; Alexander Pfeifer; Gregor-Alexander Pilz; Alexandra Raulf; Wilhelm Röll; Hans R Schöler; Christian Steinhäuser; Jonel Trebicka; Armin Welz; Holm Zaehres; Katrin Zimmermann; Christopher J Fügemann; Magdalena Götz; Christian Haberlandt; Bernd K Fleischmann
Direct visualization of cell division using high-resolution imaging of M-phase of the cell cycle.
Nature communications 2012;3():1076.
2011: Daniela Malan; Bernd K Fleischmann; Stephanie Friedrichs; Philipp Sasse
Cardiomyocytes obtained from induced pluripotent stem cells with long-QT syndrome 3 recapitulate typical disease-specific features in vitro.
Circulation research 2011;109(8):841-7.
2011: Alexander Ghanem; Georg Nickenig; Wilhelm Röll; Jörg Stypmann; Toktam Bostani; Oliver Dewald; Bernd K Fleischmann; Klaus Tiemann
Cardiomyoplasty improves contractile reserve after myocardial injury in mice: functional and morphological investigations with reconstructive three-dimensional echocardiography.
Cell transplantation 2011;20(10):1621-8.
2010: Christopher J Fuegemann; Ajoy K Samraj; Stuart Walsh; Bernd K Fleischmann; Stefan Jovinge; Martin Breitbach
Differentiation of mouse embryonic stem cells into cardiomyocytes via the hanging-drop and mass culture methods.
Current protocols in stem cell biology 2010;Chapter 1():Unit 1F.11.
2010: Alexander Kleger; Thomas Seufferlein; Daniela Malan; Michael Tischendorf; Alexander Storch; Anne Wolheim; Stephan Latz; Stephanie Protze; Marc Porzner; Christian Proepper; Cornelia Brunner; Sarah-Fee Katz; Ganesh Varma Pusapati; Lars Bullinger; Wolfgang-Michael Franz; Ralf Koehntop; Klaudia Giehl; Andreas Spyrantis; Oliver H Wittekindt; Qiong Lin; Quiong Lin; Martin Zenke; Bernd K Fleischmann; Maria Wartenberg; Anna M Wobus; Tobias M Boeckers; Stefan Liebau
Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells.
Circulation 2010;122(18):1823-36.
2010: Larissa Fabritz; Bernd K Fleischmann; Boris Greber; Paulus Kirchhof
Cell-based therapy of the failing heart: a need to connect for proper electrical and contractile function.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2010;12(11):1520-1.
2010: Tobias Bruegmann; Daniela Malan; Michael Hesse; Thomas Beiert; Christopher J Fuegemann; Bernd K Fleischmann; Philipp Sasse
Optogenetic control of heart muscle in vitro and in vivo.
Nature methods 2010;7(11):897-900.
2010: Marina Frank; Britta Eiberger; Ulrike Janssen-Bienhold; Luis Pérez de Sevilla Müller; Antje Tjarks; Jung Sun Kim; Stefan Maschke; Radoslaw Dobrowolski; Philipp Sasse; Reto Weiler; Bernd K Fleischmann; Klaus Willecke
Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart.
Journal of cell science 2010;123(Pt 20):3605-15.
2010: Kurt Pfannkuche; Sabine Neuss; Frank Pillekamp; Lukas P Frenzel; Wael Attia; Tobias Hannes; Jochen Salber; Mareike Hoss; Martin Zenke; Bernd K Fleischmann; Jürgen Hescheler; Tomo Sarić
Fibroblasts facilitate the engraftment of embryonic stem cell-derived cardiomyocytes on three-dimensional collagen matrices and aggregation in hanging drops.
Stem cells and development 2010;19(10):1589-99.
2010: Jan Schrickel; Florian Stöckigt; Wieslaw Krzyzak; Denise Paulin; Zhenlin Li; Indra Lübkemeier; Bernd K Fleischmann; Philipp Sasse; Markus Linhart; Thorsten Lewalter; Georg Nickenig; Lars Lickfett; Rolf Schröder; Christoph S Clemen
Cardiac conduction disturbances and differential effects on atrial and ventricular electrophysiological properties in desmin deficient mice.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2010;28(2):71-80.
2010: Stuart Walsh; Annica Pontén; Bernd K Fleischmann; Stefan Jovinge
Cardiomyocyte cell cycle control and growth estimation in vivo--an analysis based on cardiomyocyte nuclei.
Cardiovascular research 2010;86(3):365-73.
2010: Daniela Malan; Daniela Wenzel; Annette Schmidt; Caroline Geisen; Axel Raible; Birgit Bölck; Bernd K Fleischmann; Wilhelm Bloch
Endothelial beta1 integrins regulate sprouting and network formation during vascular development.
Development (Cambridge, England) 2010;137(6):993-1002.
2010: Verena Arndt; Nikolaus Dick; Riga Tawo; Michael Dreiseidler; Daniela Wenzel; Michael Hesse; Dieter O Fürst; Paul Saftig; Robert Saint; Bernd K Fleischmann; Michael Hoch; Jörg Höhfeld
Chaperone-assisted selective autophagy is essential for muscle maintenance.
Current biology : CB 2010;20(2):143-8.
2010: Huamin Liang; Marcel Halbach; Tobias Hannes; Bernd K Fleischmann; Ming Tang; Heribert Schunkert; Jürgen Hescheler; Michael Reppel
Electrophysiological basis of the first heart beats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(6):561-70.
2009: Ulrich M Becher; Martin Breitbach; Philipp Sasse; Stephan Garbe; Peter F.M. van der Ven; Dieter O Fürst; Bernd K Fleischmann
Enrichment and terminal differentiation of striated muscle progenitors in vitro.
Experimental cell research 2009;315(16):2741-51.
2009: Kinarm Ko; Natalia Tapia; Guangming Wu; Jeong Beom Kim; Marcos J Araúzo Bravo; Philipp Sasse; Tamara Glaser; David Ruau; Dong Wook Han; Boris Greber; Kirsten Hausdörfer; Vittorio Sebastiano; Martin Stehling; Bernd K Fleischmann; Oliver Brüstle; Martin Zenke; Hans R Schöler
Induction of pluripotency in adult unipotent germline stem cells.
Cell stem cell 2009;5(1):87-96.
2009: Daniela Wenzel; Ralf Knies; Michaela Matthey; Alexandra M Klein; Julia Welschoff; Vanessa Stolle; Philipp Sasse; Wilhelm Röll; Johannes Breuer; Bernd K Fleischmann
beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway.
Hypertension 2009;54(1):157-63.
2009: Gerd Zolles; Daniela Wenzel; Wolfgang Bildl; Uwe Schulte; Andreas Hofmann; Catrin S Müller; Jörg Oliver Thumfart; Andreas Vlachos; Thomas Deller; Alexander Pfeifer; Bernd K Fleischmann; Jochen Roeper; Bernd Fakler; Nikolaj Klöcker
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation.
Neuron 2009;62(6):814-25.
2009: Filomain Nguemo; Philipp Sasse; Bernd K Fleischmann; Albert Kamanyi; Heribert Schunkert; Jürgen Hescheler; Michael Reppel
Modulation of L-type Ca(2+) channel current density and inactivation by beta-adrenergic stimulation during murine cardiac embryogenesis.
Basic research in cardiology 2009;104(3):295-306.
2009: Yvonne N Tallini; Kai Su Greene; Michael Craven; Alyson Spealman; Martin Breitbach; James Smith; Patricia J Fisher; Michele Steffey; Michael Hesse; Robert Doran; Ashley Woods; Babu Singh; Andrew Yen; Bernd K Fleischmann; Michael I Kotlikoff
c-kit expression identifies cardiovascular precursors in the neonatal heart.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1808-13.
2009: Jeong Beom Kim; Vittorio Sebastiano; Guangming Wu; Marcos J Arauzo-Bravo; Philipp Sasse; Luca Gentile; Kinarm Ko; David Ruau; Mathias Ehrich; Dirk van den Boom; Johann Meyer; Karin Hübner; Christof Bernemann; Claudia Ortmeier; Martin Zenke; Bernd K Fleischmann; Holm Zaehres; Hans R Schöler
Oct4-induced pluripotency in adult neural stem cells.
Cell 2009;136(3):411-9.
2009: Andreas Hofmann; Daniela Wenzel; Ulrich M Becher; Daniel F Freitag; Alexandra M Klein; Dietmar Eberbeck; Maike Schulte; Katrin Zimmermann; Christian Bergemann; Bernhard Gleich; Wilhelm Roell; Thomas Weyh; Lutz Trahms; Georg Nickenig; Bernd K Fleischmann; Alexander Pfeifer
Combined targeting of lentiviral vectors and positioning of transduced cells by magnetic nanoparticles.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):44-9.
2009: Daniela Malan; Michael Reppel; Radoslaw Dobrowolski; Wilhelm Roell; Neil Smyth; Juergen Hescheler; Mats Paulsson; Wilhelm Bloch; Bernd K Fleischmann
Lack of laminin gamma1 in embryonic stem cell-derived cardiomyocytes causes inhomogeneous electrical spreading despite intact differentiation and function.
Stem cells (Dayton, Ohio) 2009;27(1):88-99.
2008: Philipp Sasse; Daniela Malan; Michaela Fleischmann; Wilhelm Roell; Erika Elisabet Gustafsson; Toktam Bostani; Yun Fan; Thomas Kolbe; Martin Breitbach; Klaus Addicks; Armin Welz; Gottfried Brem; Jürgen Hescheler; Attila Aszodi; Mercedes Costell; Wilhelm Bloch; Bernd K Fleischmann
Perlecan is critical for heart stability.
Cardiovascular research 2008;80(3):435-44.
2008: Tamara Glaser; Thoralf Opitz; Thomas Kischlat; Rachel Konang; Philipp Sasse; Bernd K Fleischmann; Wolfgang Engel; Karim Nayernia; Oliver Brüstle
Adult germ line stem cells as a source of functional neurons and glia.
Stem cells (Dayton, Ohio) 2008;26(9):2434-43.
2008: Jens Nygren; Karina Liuba; Martin Breitbach; Simon Stott; Lina Thorén; Wilhelm Roell; Caroline Geisen; Philipp Sasse; Deniz Kirik; Anders Björklund; Claus Nerlov; Bernd K Fleischmann; Stefan Jovinge; Sten Eirik W Jacobsen
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
Nature cell biology 2008;10(5):584-92.
2008: Radoslaw Dobrowolski; Philipp Sasse; Jan Schrickel; Marcus Watkins; Jung Sun Kim; Mindaugas Rackauskas; Clemens Troatz; Alexander Ghanem; Klaus Tiemann; Joachim Degen; Feliksas F Bukauskas; Roberto Civitelli; Thorsten Lewalter; Bernd K Fleischmann; Klaus Willecke
The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans.
Human molecular genetics 2008;17(4):539-54.
2007: Wilhelm Roell; Thorsten Lewalter; Philipp Sasse; Yvonne N Tallini; Bum-Rak Choi; Martin Breitbach; Robert Doran; Ulrich M Becher; Seong-Min Hwang; Toktam Bostani; Julia von Maltzahn; Andreas Hofmann; Shaun Reining; Britta Eiberger; Bethann Gabris; Alexander Pfeifer; Armin Welz; Klaus Willecke; Guy Salama; Jan Schrickel; Michael I Kotlikoff; Bernd K Fleischmann
Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia.
Nature 2007;450(7171):819-24.
2007: Jan Schrickel; Klara Brixius; Claudia Herr; Christoph S Clemen; Philipp Sasse; Kathrin Reetz; Christian Grohé; Rainer Meyer; Klaus Tiemann; Rolf Schröder; Wilhelm Bloch; Georg Nickenig; Bernd K Fleischmann; Angelika A Noegel; Robert H G Schwinger; Thorsten Lewalter
Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice.
Cardiovascular research 2007;76(2):257-68.
2007: Martin Breitbach; Toktam Bostani; Wilhelm Roell; Ying Xia; Oliver Dewald; Jens Nygren; Jochen W U Fries; Klaus Tiemann; Heribert Bohlen; Jürgen Hescheler; Armin Welz; Wilhelm Bloch; Sten Eirik W Jacobsen; Bernd K Fleischmann
Potential risks of bone marrow cell transplantation into infarcted hearts.
Blood 2007;110(4):1362-9.
2007: Philipp Sasse; Jianbao Zhang; Lars Cleemann; Martin Morad; Jürgen Hescheler; Bernd K Fleischmann
Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells.
The Journal of general physiology 2007;130(2):133-44.
2007: Michael Reppel; Bernd K Fleischmann; Hannes Reuter; Philipp Sasse; Heribert Schunkert; Jürgen Hescheler
Regulation of the Na+/Ca2+ exchanger (NCX) in the murine embryonic heart.
Cardiovascular research 2007;75(1):99-108.
2007: Zeinab Abdullah; Tomo Saric; Hamid Kashkar; Nikola Baschuk; Benjamin Yazdanpanah; Bernd K Fleischmann; Jürgen Hescheler; Martin Krönke; Olaf Utermöhlen
Serpin-6 expression protects embryonic stem cells from lysis by antigen-specific CTL.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3390-9.
2007: Michael Reppel; Bernd K Fleischmann; Hannes Reuter; Frank Pillekamp; Heribert Schunkert; Jürgen Hescheler
Regulation of Na+/Ca2+ exchange current in the normal and failing heart.
Annals of the New York Academy of Sciences 2007;1099():361-72.
2007: Michael Reppel; Hannes Reuter; Philipp Sasse; Jürgen Hescheler; Bernd K Fleischmann
NCX current in the murine embryonic heart: development-dependent regulation by Na+.
Annals of the New York Academy of Sciences 2007;1099():175-82.
2007: Filomain Nguemo; Bernd K Fleischmann; Heribert Schunkert; Jürgen Hescheler; Michael Reppel
Functional expression and inactivation of L-type Ca2+ currents during murine heart development - implications for cardiac Ca2+ homeostasis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(6):809-24.
2007: Nora Lang; Michael Reppel; Jürgen Hescheler; Bernd K Fleischmann
NO underlies the muscarinic receptor-mediated inhibition of If in early embryonic heart cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007;20(5):293-302.
2007: Michael Reppel; Philipp Sasse; Daniela Malan; Filomain Nguemo; Hannes Reuter; Wilhelm Bloch; Jürgen Hescheler; Bernd K Fleischmann
Functional expression of the Na+/Ca2+ exchanger in the embryonic mouse heart.
Journal of molecular and cellular cardiology 2007;42(1):121-32.
2006: Gerd Zolles; Nikolaj Klöcker; Daniela Wenzel; Jutta Weisser-Thomas; Bernd K Fleischmann; Jochen Roeper; Bernd Fakler
Pacemaking by HCN channels requires interaction with phosphoinositides.
Neuron 2006;52(6):1027-36.
2006: Jochen Müller-Ehmsen; Benjamin Krausgrill; Volker Burst; Kerstin Schenk; Uta C Neisen; Jochen W U Fries; Bernd K Fleischmann; Jürgen Hescheler; Robert H G Schwinger
Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction.
Journal of molecular and cellular cardiology 2006;41(5):876-84.
2006: Eugen Kolossov; Toktam Bostani; Wilhelm Roell; Martin Breitbach; Frank Pillekamp; Jens Nygren; Philipp Sasse; Olga Rubenchik; Jochen W U Fries; Daniela Wenzel; Caroline Geisen; Ying Xia; Zhongju Lu; Yaqi Duan; Ralf Kettenhofen; Stefan Jovinge; Wilhelm Bloch; Heribert Bohlen; Armin Welz; Jürgen Hescheler; Sten Eirik W Jacobsen; Bernd K Fleischmann
Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium.
The Journal of experimental medicine 2006;203(10):2315-27.
2006: Petra Weissgerber; Brigitte Held; Wilhelm Bloch; Lars Kaestner; Kenneth R Chien; Bernd K Fleischmann; Peter Lipp; Veit Flockerzi; Marc Freichel
Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation.
Circulation research 2006;99(7):749-57.
2006: D Wenzel; Annette Schmidt; Katrin Reimann; Jürgen Hescheler; Gabriele Pfitzer; Wilhelm Bloch; Bernd K Fleischmann
Endostatin, the proteolytic fragment of collagen XVIII, induces vasorelaxation.
Circulation research 2006;98(9):1203-11.
2006: Annette Schmidt; Daniela Wenzel; Irmgard Thorey; Takako Sasaki; Jürgen Hescheler; Rupert Timpl; Klaus Addicks; Sabine Werner; Bernd K Fleischmann; Wilhelm Bloch
Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction.
Microvascular research 2006;71(3):152-62.
2005: Michael Reppel; Philipp Sasse; Roland P Piekorz; Ming Tang; Wilhelm Roell; Yaqi Duan; Anja Kletke; Jürgen Hescheler; Bernd Nürnberg; Bernd K Fleischmann
S100A1 enhances the L-type Ca2+ current in embryonic mouse and neonatal rat ventricular cardiomyocytes.
The Journal of biological chemistry 2005;280(43):36019-28.
2005: Ekkehard Küstermann; Wilhelm Roell; Martin Breitbach; Stefan Wecker; Dirk Wiedermann; Christian Buehrle; Armin Welz; Jürgen Hescheler; Bernd K Fleischmann; Mathias Hoehn
Stem cell implantation in ischemic mouse heart: a high-resolution magnetic resonance imaging investigation.
NMR in biomedicine 2005;18(6):362-70.
2005: Annette Schmidt; Daniela Wenzel; Irmgard Thorey; Sabine Werner; Bernd K Fleischmann; Wilhelm Bloch
Endostatin down-regulates soluble guanylate cyclase (sGC) in endothelial cells in vivo: influence of endostatin on vascular endothelial growth factor (VEGF) signaling.
Endothelium : journal of endothelial cell research 2005;12(5-6):251-7.
2005: Eugen Kolossov; Z Lu; Irina Drobinskaya; N Gassanov; Yaqi Duan; Heinrich Sauer; Oliver Manzke; Wilhelm Bloch; Heribert Bohlen; Jürgen Hescheler; Bernd K Fleischmann
Identification and characterization of embryonic stem cell-derived pacemaker and atrial cardiomyocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(6):577-9.
2005: Frank Pillekamp; Michael Reppel; Vera Dinkelacker; Yaqi Duan; Nathalie Jazmati; Wilhelm Bloch; Konrad Brockmeier; Jürgen Hescheler; Bernd K Fleischmann; Rüdiger Köhling
Establishment and characterization of a mouse embryonic heart slice preparation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2005;16(1-3):127-32.
2004: Jürgen Hescheler; Maria Wartenberg; Daniela Wenzel; B K W Roell; Zhongju Lu; Ying Xia; F Dönmez; Frederike C Ling; Helmut Acker; Eugen Kolossov; Shohreh Kazemi; Philipp Sasse; Axel Raible; Heribert Bohlen; Wilhelm Bloch; Heinrich Sauer; Armin Welz; Bernd K Fleischmann
Implication of therapeutic cloning for organ transplantation.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2004;26 Suppl 1():S54-5; discussion S55-6.
2004: Klara Brixius; Wilhelm Bloch; Christian Pott; Andreas Napp; Andreas Krahwinkel; Christoph Ziskoven; Marco Koriller; Uwe Mehlhorn; Jürgen Hescheler; Bernd K Fleischmann; Robert H G Schwinger
Mechanisms of beta 3-adrenoceptor-induced eNOS activation in right atrial and left ventricular human myocardium.
British journal of pharmacology 2004;143(8):1014-22.
2004: Bernd K Fleischmann; Yaqi Duan; Yun Fan; Torsten Schöneberg; Andreas Ehlich; Nibedita Lenka; Serge Viatchenko-Karpinski; Lutz Pott; Jürgen Hescheler; Bernd Fakler
Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development.
The Journal of clinical investigation 2004;114(7):994-1001.
2004: Dimitry Spitkovsky; Philipp Sasse; Eugen Kolossov; Cornelia Böttinger; Bernd K Fleischmann; Jürgen Hescheler; Rudolf J Wiesner
Activity of complex III of the mitochondrial electron transport chain is essential for early heart muscle cell differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(11):1300-2.
2004: Jürgen Hescheler; A Welz; Bernd K Fleischmann
Searching for reputability: first randomised study on bone-marrow transplantation in the heart.
Lancet 2004;364(9429):121-2.
2004: Annette Schmidt; Daniela Wenzel; Isabell Ferring; Shohreh Kazemi; Takako Sasaki; Jürgen Hescheler; Rupert Timpl; Klaus Addicks; Bernd K Fleischmann; Wilhelm Bloch
Influence of endostatin on embryonic vasculo- and angiogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;230(3):468-80.
2004: Daniela Malan; Guan J Ji; Annette Schmidt; Klaus Addicks; Jürgen Hescheler; Renzo Levi; Wilhelm Bloch; Bernd K Fleischmann
Nitric oxide, a key signaling molecule in the murine early embryonic heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(10):1108-10.
2004: Franciska Erdo; Thorsten Trapp; Christian Bührle; Bernd K Fleischmann; Konstantin-Alexander Hossmann
[Embryonic stem cell therapy in experimental stroke: host-dependent malignant transformation].
Orvosi hetilap 2004;145(25):1307-13.
2004: Jens Nygren; Stefan Jovinge; Martin Breitbach; Petter Säwén; Wilhelm Röll; Jürgen Hescheler; Jalal Taneera; Bernd K Fleischmann; Sten Eirik W Jacobsen
Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation.
Nature medicine 2004;10(5):494-501.
2004: Jürgen Hescheler; Marcel Halbach; Ulrich Egert; Zhong Ju Lu; Heribert Bohlen; Bernd K Fleischmann; Michael Reppel
Determination of electrical properties of ES cell-derived cardiomyocytes using MEAs.
Journal of electrocardiology 2004;37 Suppl():110-6.
2004: Michael Reppel; Frank Pillekamp; Zhong Ju Lu; Marcel Halbach; Konrad Brockmeier; Bernd K Fleischmann; Jürgen Hescheler
Microelectrode arrays: a new tool to measure embryonic heart activity.
Journal of electrocardiology 2004;37 Suppl():104-9.
2003: Marc Brede; Wilhelm Roell; Oliver Ritter; Frank Wiesmann; Roland Jahns; Axel Haase; Bernd K Fleischmann; Lutz Hein
Cardiac hypertrophy is associated with decreased eNOS expression in angiotensin AT2 receptor-deficient mice.
Hypertension 2003;42(6):1177-82.
2003: Franciska Erdö; Christian Bührle; James A Blunk; Mathias Hoehn; Ying Xia; Bernd K Fleischmann; Melanie Foecking; Ekkehard Küstermann; Eugen Kolossov; Jürgen Hescheler; Konstantin-Alexander Hossmann; Thorsten Trapp
Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(7):780-5.
2003: Agapios Sachinidis; Bernd K Fleischmann; Eugen Kolossov; Maria Wartenberg; Heinrich Sauer; Jürgen Hescheler
Cardiac specific differentiation of mouse embryonic stem cells.
Cardiovascular research 2003;58(2):278-91.
2003: Sharon Siedner; Martina Krüger; Mechthild Schroeter; Doris Metzler; Wilhelm Roell; Bernd K Fleischmann; Jürgen Hescheler; Gabriele Pfitzer; Robert Stehle
Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart.
The Journal of physiology 2003;548(Pt 2):493-505.
2002: Mathias Hoehn; Ekkehard Küstermann; James A Blunk; Dirk Wiedermann; Thorsten Trapp; Stefan Wecker; Melanie Foecking; Heinz Arnold; Jürgen Hescheler; Bernd K Fleischmann; Wolfram Schwindt; Christian Bührle
Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):16267-72.
2002: Agapios Sachinidis; Eugen Kolossov; Bernd K Fleischmann; Jürgen Hescheler
Generation of cardiomyocytes from embryonic stem cells experimental studies.
Herz 2002;27(7):589-97.
2002: Manabu Murakami; Bernd K Fleischmann; Carmen De Felipe; Marc Freichel; Claudia Trost; Andreas Ludwig; Ulrich Wissenbach; Herbert Schwegler; Franz Hofmann; Jürgen Hescheler; Veit Flockerzi; Adolfo Cavalié
Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels.
The Journal of biological chemistry 2002;277(43):40342-51.
2002: Qing-Hua Liu; Bernd K Fleischmann; Brian Hondowicz; Curtis C Maier; Laurence A Turka; Katsuyuki Yui; Michael I Kotlikoff; Andrew D Wells; Bruce D Freedman
Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation.
The Journal of experimental medicine 2002;196(7):897-909.
2002: Martin Paparella; Eugen Kolossov; Bernd K Fleischmann; Jürgen Hescheler; Susanne Bremer
The use of quantitative image analysis in the assessment of in vitro embryotoxicity endpoints based on a novel embryonic stem cell clone with endoderm-related GFP expression.
Toxicology in vitro : an international journal published in association with BIBRA 2002;16(5):589-97.
2002: Wilhelm Roell; Zhong Ju Lu; Wilhelm Bloch; Sharon Siedner; Klaus Tiemann; Ying Xia; Eva Stoecker; Michaela Fleischmann; Heribert Bohlen; Robert Stehle; Eugen Kolossov; Gottfried Brem; Klaus Addicks; Gabriele Pfitzer; Armin Welz; Jürgen Hescheler; Bernd K Fleischmann
Cellular cardiomyoplasty improves survival after myocardial injury.
Circulation 2002;105(20):2435-41.
2002: Nibedita Lenka; Zhong Ju Lu; Philipp Sasse; Jürgen Hescheler; Bernd K Fleischmann
Quantitation and functional characterization of neural cells derived from ES cells using nestin enhancer-mediated targeting in vitro.
Journal of cell science 2002;115(Pt 7):1471-85.
2002: Wilhelm Roell; Yun Fan; Ying Xia; Eva Stoecker; Philipp Sasse; Eugen Kolossov; Wilhelm Bloch; Harald Metzner; Christoph Schmitz; Klaus Addicks; Jürgen Hescheler; Armin Welz; Bernd K Fleischmann
Cellular cardiomyoplasty in a transgenic mouse model.
Transplantation 2002;73(3):462-5.
2002: Jürgen Hescheler; Bernd K Fleischmann
Regulation of voltage-dependent Ca2+ channels in the early developing heart: role of beta1 integrins.
Basic research in cardiology 2002;97 Suppl 1():I153-8.
2002: Shohreh Kazemi; Daniela Wenzel; Eugen Kolossov; Nibedita Lenka; Axel Raible; Philipp Sasse; Jürgen Hescheler; Klaus Addicks; Bernd K Fleischmann; Wilhelm Bloch
Differential role of bFGF and VEGF for vasculogenesis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2002;12(2-3):55-62.
2001: Wilhelm Bloch; Y Fan; J Han; S Xue; Torsten Schöneberg; G Ji; Zhong Ju Lu; M Walther; Reinhard Fässler; Jürgen Hescheler; Klaus Addicks; Bernd K Fleischmann
Disruption of cytoskeletal integrity impairs Gi-mediated signaling due to displacement of Gi proteins.
The Journal of cell biology 2001;154(4):753-61.
2001: Jürgen Hescheler; Bernd K Fleischmann
Indispensable tools: embryonic stem cells yield insights into the human heart.
The Journal of clinical investigation 2001;108(3):363-4.
2001: M Dittrich; Jonas Jurevicius; Marie Georget; Francesca Rochais; Bernd K Fleischmann; J Hescheler; Rodolphe Fischmeister
Local response of L-type Ca(2+) current to nitric oxide in frog ventricular myocytes.
The Journal of physiology 2001;534(Pt 1):109-21.
2001: Claudia Herr; Neil Smyth; Susanne Ullrich; F Yun; Philipp Sasse; Jürgen Hescheler; Bernd K Fleischmann; Kathrin Lasek; Klara Brixius; Robert H G Schwinger; Reinhard Fässler; Rolf Schröder; Angelika A Noegel
Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes.
Molecular and cellular biology 2001;21(13):4119-28.
2001: Susanne Bremer; Andrew P Worth; Martin Paparella; K Bigot; Eugen Kolossov; Bernd K Fleischmann; Jürgen Hescheler; Michael Balls
Establishment of an in vitro reporter gene assay for developmental cardiac toxicity.
Toxicology in vitro : an international journal published in association with BIBRA 2001;15(3):215-23.
2001: Christian Andressen; E Stöcker; Franz-Josef Klinz; Nibedita Lenka; Jürgen Hescheler; Bernd K Fleischmann; Stefan Arnhold; Klaus Addicks
Nestin-specific green fluorescent protein expression in embryonic stem cell-derived neural precursor cells used for transplantation.
Stem cells (Dayton, Ohio) 2001;19(5):419-24.
2000: M Müller; Bernd K Fleischmann; Stefan Selbert; Guan J Ji; Elmar Endl; Guido Middeler; O J Müller; Peter Schlenke; S Frese; Anna M Wobus; Jürgen Hescheler; Hugo A Katus; Wolfgang M Franz
Selection of ventricular-like cardiomyocytes from ES cells in vitro.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(15):2540-8.
2000: Najah Abi-Gerges; Guan J Ji; Zhong Ju Lu; Rodolphe Fischmeister; Jürgen Hescheler; Bernd K Fleischmann
Functional expression and regulation of the hyperpolarization activated non-selective cation current in embryonic stem cell-derived cardiomyocytes.
The Journal of physiology 2000;523 Pt 2():377-89.
1999: O Gryshchenko; I R Fischer; M Dittrich; Serge Viatchenko-Karpinski; J Soest; M M Böhm-Pinger; Peter Igelmund; Bernd K Fleischmann; Jürgen Hescheler
Role of ATP-dependent K(+) channels in the electrical excitability of early embryonic stem cell-derived cardiomyocytes.
Journal of cell science 1999;112 ( Pt 17)():2903-12.
1999: Oliver Manzke; K J Fitzgerald; Philipp Holliger; J Klock; M Span; Bernd K Fleischmann; Jürgen Hescheler; L Qinghua; K S Johnson; Volker Diehl; H R Hoogenboom; Heribert Bohlen
CD3X anti-nitrophenyl bispecific diabodies: universal immunotherapeutic tools for retargeting T cells to tumors.
International journal of cancer. Journal international du cancer 1999;82(5):700-8.
1999: Wilhelm Bloch; Bernd K Fleischmann; D E Lorke; Christian Andressen; B Hops; Jürgen Hescheler; Klaus Addicks
Nitric oxide synthase expression and role during cardiomyogenesis.
Cardiovascular research 1999;43(3):675-84.
1999: Serge Viatchenko-Karpinski; Bernd K Fleischmann; Q Liu; Heinrich Sauer; O Gryshchenko; Guan J Ji; Jürgen Hescheler
Intracellular Ca2+ oscillations drive spontaneous contractions in cardiomyocytes during early development.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8259-64.
1999: Philipp Holliger; Oliver Manzke; M Span; R Hawkins; Bernd K Fleischmann; L Qinghua; J Wolf; V Diehl; O Cochet; Greg Winter; Heribert Bohlen
Carcinoembryonic antigen (CEA)-specific T-cell activation in colon carcinoma induced by anti-CD3 x anti-CEA bispecific diabodies and B7 x anti-CEA bispecific fusion proteins.
Cancer research 1999;59(12):2909-16.
1999: Bruce D Freedman; Qing-Hua Liu; Glen N Gaulton; Michael I Kotlikoff; J Hescheler; Bernd K Fleischmann
ATP-evoked Ca2+ transients and currents in murine thymocytes: possible role for P2X receptors in death by neglect.
European journal of immunology 1999;29(5):1635-46.
1999: Peter Igelmund; Bernd K Fleischmann; I R Fischer; J Soest; O Gryshchenko; M M Böhm-Pinger; Heinrich Sauer; Q Liu; Jürgen Hescheler
Action potential propagation failures in long-term recordings from embryonic stem cell-derived cardiomyocytes in tissue culture.
Pflügers Archiv : European journal of physiology 1999;437(5):669-79.
1999: Victor A Maltsev; Guan J Ji; Anna M Wobus; Bernd K Fleischmann; Jürgen Hescheler
Establishment of beta-adrenergic modulation of L-type Ca2+ current in the early stages of cardiomyocyte development.
Circulation research 1999;84(2):136-45.
1999: Guan J Ji; Bernd K Fleischmann; Wilhelm Bloch; M Feelisch; Christian Andressen; Klaus Addicks; Jürgen Hescheler
Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(2):313-24.
1999: Jürgen Hescheler; Bernd K Fleischmann; Maria Wartenberg; Wilhelm Bloch; Eugen Kolossov; G Ji; Klaus Addicks; Heinrich Sauer
Establishment of ionic channels and signalling cascades in the embryonic stem cell-derived primitive endoderm and cardiovascular system.
Cells, tissues, organs 1999;165(3-4):153-64.
1998: Eugen Kolossov; Bernd K Fleischmann; Q Liu; Wilhelm Bloch; Serge Viatchenko-Karpinski; Oliver Manzke; Guan J Ji; Heribert Bohlen; Klaus Addicks; Jürgen Hescheler
Functional characteristics of ES cell-derived cardiac precursor cells identified by tissue-specific expression of the green fluorescent protein.
The Journal of cell biology 1998;143(7):2045-56.
1997: Jürgen Hescheler; Bernd K Fleischmann; S Lentini; Victor A Maltsev; Jürgen Rohwedel; Anna M Wobus; Klaus Addicks
Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis.
Cardiovascular research 1997;36(2):149-62.
1997: YX Wang; Bernd K Fleischmann; Michael I Kotlikoff
M2 receptor activation of nonselective cation channels in smooth muscle cells: calcium and Gi/G(o) requirements.
The American journal of physiology 1997;273(2 Pt 1):C500-8.
1997: Anna M Wobus; G Kaomei; J Shan; M C Wellner; Jürgen Rohwedel; Bernd K Fleischmann; H A Katus; Jürgen Hescheler; Wolfgang M Franz
Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes.
Journal of molecular and cellular cardiology 1997;29(6):1525-39.
1997: YX Wang; Bernd K Fleischmann; Michael I Kotlikoff
Modulation of maxi-K+ channels by voltage-dependent Ca2+ channels and methacholine in single airway myocytes.
The American journal of physiology 1997;272(4 Pt 1):C1151-9.
1997: Bernd K Fleischmann; YX Wang; Michael I Kotlikoff
Muscarinic activation and calcium permeation of nonselective cation currents in airway myocytes.
The American journal of physiology 1997;272(1 Pt 1):C341-9.
1996: S Adda; Bernd K Fleischmann; Bruce D Freedman; M Yu; D W Hay; Michael I Kotlikoff
Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle.
The Journal of biological chemistry 1996;271(22):13239-43.
1996: Bernd K Fleischmann; Y X Wang; M Pring; Michael I Kotlikoff
Voltage-dependent calcium currents and cytosolic calcium in equine airway myocytes.
The Journal of physiology 1996;492 ( Pt 2)():347-58.
1995: Bruce D Freedman; Bernd K Fleischmann; J A Punt; Glen N Gaulton; Y Hashimoto; Michael I Kotlikoff
Identification of Kv1.1 expression by murine CD4-CD8- thymocytes. A role for voltage-dependent K+ channels in murine thymocyte development.
The Journal of biological chemistry 1995;270(38):22406-11.
1994: Bernd K Fleischmann; R K Murray; Michael I Kotlikoff
Voltage window for sustained elevation of cytosolic calcium in smooth muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11914-8.
1993: Bernd K Fleischmann; Robert J Washabau; Michael I Kotlikoff
Control of resting membrane potential by delayed rectifier potassium currents in ferret airway smooth muscle cells.
The Journal of physiology 1993;469():625-38.
1993: R K Murray; Bernd K Fleischmann; Michael I Kotlikoff
Receptor-activated Ca influx in human airway smooth muscle: use of Ca imaging and perforated patch-clamp techniques.
The American journal of physiology 1993;264(2 Pt 1):C485-90.