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Thomas Fleisher

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Hye Sun Kuehn; Douglas B Kuhns; Julie E Niemela; C Lucy Park; Stefania Pittaluga; Debra A Long Priel; Andreia Rangel-Santos; Jennifer L Stoddard; Gulbu Uzel; Mingchang Zhang; Moses O Evbuomwan; Thomas A Fleisher; Ashleigh A Hussey; João B Oliveira
Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans.
Sergio D Rosenzweig; Thomas A Fleisher
Laboratory evaluation for T-cell dysfunction.
Thomas A Waldmann; TatYana A Worthy; Michael N Petrus; Mark Raffeld; Shawn D Spencer; Donn M Stewart; Paul S Albert; B Bryant; Kevin C Conlon; Stephen Creekmore; Jean R Decker; William D Figg; Thomas A Fleisher; Carolyn K Goldman; John Janik; John C Morris
Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia.

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2013: Hye Sun Kuehn; Douglas B Kuhns; Julie E Niemela; C Lucy Park; Stefania Pittaluga; Debra A Long Priel; Andreia Rangel-Santos; Jennifer L Stoddard; Gulbu Uzel; Mingchang Zhang; Moses O Evbuomwan; Thomas A Fleisher; Ashleigh A Hussey; João B Oliveira
Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans.
Blood 2013;121(16):3117-25.
2013: Sergio D Rosenzweig; Thomas A Fleisher
Laboratory evaluation for T-cell dysfunction.
The Journal of allergy and clinical immunology 2013;131(2):622-3.e1-4.
2013: Thomas A Waldmann; TatYana A Worthy; Michael N Petrus; Mark Raffeld; Shawn D Spencer; Donn M Stewart; Paul S Albert; B Bryant; Kevin C Conlon; Stephen Creekmore; Jean R Decker; William D Figg; Thomas A Fleisher; Carolyn K Goldman; John Janik; John C Morris
Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia.
Blood 2013;121(3):476-84.
2012: Thomas A Fleisher; Joao Bosco Oliveira
Monogenic defects in lymphocyte apoptosis.
Current opinion in allergy and clinical immunology 2012;12(6):609-15.
2012: Andrew L Snow; Louis M Staudt; Jeffrey R Stinson; Helen C Su; Wei Wang; Wenming Xiao; Lixin Zheng; Wei Lu; Helen F Matthews; Susan Moir; Stefania Pittaluga; Mark Raffeld; Roland Schmitz; Benjamin Chaigne-Delalande; Thomas A Fleisher; Sameer Jhavar; Huie Jing; Lela Kardava; Stefan Kuchen; Ian T Lamborn; Michael J Lenardo
Congenital B cell lymphocytosis explained by novel germline CARD11 mutations.
The Journal of experimental medicine 2012;209(12):2247-61.
2012: Xiying Fan; Ronald Fayer; Thomas A Fleisher; Theo Heller; Ronald Hornung; Aaron Bodansky; Pamela Edmonds; David Kleiner; Christopher Koh; Chi A Ma; Joao B Oliveira; Stefania Pittaluga; Calman Prussin; Mónica Santín-Durán; Bhaskar Upadhyaya; Gulbu Uzel; Ester Williams; Duane W Wong; Liming Wu; Ashish Jain
CD40 agonist antibody mediated improvement of chronic Cryptosporidium infection in patients with X-linked hyper IgM syndrome.
Clinical immunology (Orlando, Fla.) 2012;143(2):152-61.
2012: Raffick A R Bowen; Janet K Dale; Kennichi C Dowdell; Steven K Drake; Thomas A Fleisher; Glen L Hortin; Ebba Nexo; Alan T Remaley; V Koneti Rao
Elevated vitamin B₁₂ levels in autoimmune lymphoproliferative syndrome attributable to elevated haptocorrin in lymphocytes.
Clinical biochemistry 2012;45(6):490-2.
2012: Orathai Jirapongsananuruk; Voravich Luangwedchakarn; Julie E Niemela; Preeyacha Pacharn; Surapon Piboonpocanun; Charin Thepthai; Pakit Vichyanond; Nualanong Visitsunthorn; Thomas A Fleisher
Cryptococcal osteomyelitis in a child with a novel compound mutation of the IL12RB1 gene.
Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand 2012;30(1):79-82.
2011: Ashish Jain; Joseph A Kovacs; Shuying Liu; Justin Massey; Stephen A Migueles; David L Nelson; Hans Ochs; Stefania Pittaluga; Jacob J Spinner; Duane W Wong; Margaret R Brown; Victoria Davey; Xiying Fan; William Fanslow; Harry A Hill; Ronald Hornung; Thomas A Fleisher
Partial immune reconstitution of X-linked hyper IgM syndrome with recombinant CD40 ligand.
Blood 2011;118(14):3811-7.
2011: Hye Sun Kuehn; Iusta Caminha; Julie E Niemela; V Koneti Rao; Joie Davis; Thomas A Fleisher; João B Oliveira
FAS haploinsufficiency is a common disease mechanism in the human autoimmune lymphoproliferative syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):6035-43.
2011: Thomas A Waldmann; Enrico Lugli; Mario Roederer; Liyanage P Perera; Jeremy V Smedley; Rhonda P Macallister; Carolyn K Goldman; B Bryant; Jean M Decker; Thomas A Fleisher; H Clifford Lane; Michael C Sneller; Roger J Kurlander; David E Kleiner; John M Pletcher; William D Figg; Jason L Yovandich; Stephen P Creekmore
Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques.
Blood 2011;117(18):4787-95.
2011: Silvia Stojanov; Sivia Lapidus; Puja Chitkara; Henry Feder; Juan C Salazar; Thomas A Fleisher; Margaret R Brown; Kathryn M Edwards; Michael M Ward; Robert A Colbert; Hong-Wei Sun; Geryl M Wood; Beverly K Barham; Anne Jones; Ivona Aksentijevich; Raphaela Goldbach-Mansky; Balu Athreya; Karyl S Barron; Daniel Kastner
Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):7148-53.
2011: Julie E Niemela; Lianghao Lu; Thomas A Fleisher; Joie Davis; Iusta Caminha; Marc Natter; Laurel A Beer; Kennichi C Dowdell; Stefania Pittaluga; Mark Raffeld; V Koneti Rao; João B Oliveira
Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis.
Blood 2011;117(10):2883-6.
2010: Joao B Oliveira; Thomas A Fleisher
Molecular- and flow cytometry-based diagnosis of primary immunodeficiency disorders.
Current allergy and asthma reports 2010;10(6):460-7.
2010: Joao B Oliveira; Jack J H Bleesing; Umberto Dianzani; Thomas A Fleisher; Elaine S Jaffe; Michael J Lenardo; Frederic Rieux-Laucat; Richard M Siegel; Helen C Su; David T Teachey; V Koneti Rao
Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop.
Blood 2010;116(14):e35-40.
2010: Hong-Ying Wang; Vivek Gopalan; Ivona Aksentijevich; Meredith Yeager; Chi A Ma; Yasmin Ali Mohamoud; Mariam Quinones; Casey Matthews; Joseph Boland; Julie E Niemela; Troy R Torgerson; Silvia Giliani; Gulbu Uzel; Jordan S Orange; Ralph Shapiro; Luigi Notarangelo; Hans D Ochs; Thomas A Fleisher; Daniel Kastner; STEPHEN CHANOCK; Ashish Jain
A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency.
Human mutation 2010;31(9):1080-8.
2010: Kennichi C Dowdell; Julie E Niemela; Susan Price; Joie Davis; Ronald L Hornung; João Bosco Oliveira; Jennifer M Puck; Elaine S Jaffe; Stefania Pittaluga; Jeffrey I Cohen; Thomas A Fleisher; V Koneti Rao
Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome.
Blood 2010;115(25):5164-9.
2010: Iusta Caminha; Thomas A Fleisher; Ronald L Hornung; Janet K Dale; Julie E Niemela; Susan Price; Joie Davis; Katie Perkins; Kennichi C Dowdell; Margaret R Brown; V Koneti Rao; João B Oliveira
Using biomarkers to predict the presence of FAS mutations in patients with features of the autoimmune lymphoproliferative syndrome.
The Journal of allergy and clinical immunology 2010;125(4):946-949.e6.
2010: João B Oliveira; Thomas A Fleisher
Laboratory evaluation of primary immunodeficiencies.
The Journal of allergy and clinical immunology 2010;125(2 Suppl 2):S297-305.
2010: Claude Sportès; Rebecca R. Babb; Michael C Krumlauf; Frances T Hakim; Seth M Steinberg; Catherine K Chow; Margaret R Brown; Thomas A Fleisher; Pierre Noel; Irina Maric; Maryalice Stetler-Stevenson; Julie Engel; Renaud Buffet; Michel MORRE; Robert J Amato; Andrew L Pecora; CRYSTAL MACKALL; Ronald E Gress
Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(2):727-35.
2009: Linda M Griffith; Morton J Cowan; Luigi D Notarangelo; Jennifer M Puck; Rebecca H Buckley; Fabio Candotti; Mary Ellen Conley; Thomas A Fleisher; H Bobby Gaspar; Donald B Kohn; Hans D Ochs; Richard J O'Reilly; J Douglas Rizzo; Chaim M Roifman; Trudy N Small; William T Shearer
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
The Journal of allergy and clinical immunology 2009;124(6):1152-60.e12.
2009: Amy P Hsu; Thomas A Fleisher; Julie E Niemela
Mutation analysis in primary immunodeficiency diseases: case studies.
Current opinion in allergy and clinical immunology 2009;9(6):517-24.
2009: Adriana Marques; Margaret R Brown; Thomas A Fleisher
Natural killer cell counts are not different between patients with post-Lyme disease syndrome and controls.
Clinical and vaccine immunology : CVI 2009;16(8):1249-50.
2009: Voravich Luangwedchakarn; Orathai Jirapongsaranuruk; Julie E Niemela; Charin Thepthai; Kulkanya Chokephaibulkit; Sanya Sukpanichnant; Punchama Pacharn; Nualanong Visitsunthorn; Pakit Vichyanond; Surapon Piboonpocanun; Thomas A Fleisher
A novel mutation of the IL12RB1 gene in a child with nocardiosis, recurrent salmonellosis and neurofibromatosis type I: first case report from Thailand.
Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand 2009;27(2-3):161-5.
2009: Thomas A Fleisher; Joao B Oliveira
Functional flow cytometry testing: an emerging approach for the evaluation of genetic disease.
Clinical chemistry 2009;55(3):389-90.
2009: Ching Y Voss; Sara Deola; Thomas A Fleisher; Francesco M Marincola
Increased effector-target cell conjugate formation due to HLA restricted specific antigen recognition.
Immunologic research 2009;45(1):13-24.
2008: Ilia J Elenkov; Richard Kvetnansky; Akira Hashiramoto; Vladimir K Bakalov; Amrey A Link; Keith Zachman; M Crane; Daniela Jezova; Jozef Rovensky; Mariana A Dimitrov; Philip W Gold; Sergio Bonini; Thomas A Fleisher; George Chrousos; Ronald L Wilder
Low- versus high-baseline epinephrine output shapes opposite innate cytokine profiles: presence of Lewis- and Fischer-like neurohormonal immune phenotypes in humans?
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1737-45.
2008: Claude Sportès; Frances T Hakim; Sarfraz A Memon; Hua Zhang; Kevin S Chua; Margaret R Brown; Thomas A Fleisher; Michael C Krumlauf; Rebecca R. Babb; Catherine K Chow; Terry J Fry; Julie Engels; Renaud Buffet; Michel MORRE; Robert J Amato; David J Venzon; Robert Korngold; Andrew L Pecora; Ronald E Gress; CRYSTAL MACKALL
Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets.
The Journal of experimental medicine 2008;205(7):1701-14.
2008: Andrew L Snow; João B Oliveira; Lixin Zheng; Janet K Dale; Thomas A Fleisher; Michael J Lenardo
Critical role for BIM in T cell receptor restimulation-induced death.
Biology direct 2008;3():34.
2008: Thomas A Fleisher
The autoimmune lymphoproliferative syndrome: an experiment of nature involving lymphocyte apoptosis.
Immunologic research 2008;40(1):87-92.
2008: Gulbu Uzel; Emilia Tng; Sergio D Rosenzweig; Amy P Hsu; Jacqueline M Shaw; Mitchell E Horwitz; Gilda F Linton; Stacie M Anderson; Martha R Kirby; Jaõ B Oliveira; Margaret R Brown; Thomas A Fleisher; S K Alex Law; Steven M Holland
Reversion mutations in patients with leukocyte adhesion deficiency type-1 (LAD-1).
Blood 2008;111(1):209-18.
2007: V Koneti Rao; Kennichi C Dowdell; Janet K Dale; Faith Dugan; Lesley Pesnicak; Lilia L Bi; Victoria Hoffmann; Scott Penzak; Nilo A Avila; Thomas A Fleisher; Jennifer M Puck; Stephen E Straus
Pyrimethamine treatment does not ameliorate lymphoproliferation or autoimmune disease in MRL/lpr-/- mice or in patients with autoimmune lymphoproliferative syndrome.
American journal of hematology 2007;82(12):1049-55.
2007: Gabor G Illei; Cheryl H Yarboro; Takashi Kuroiwa; Ryan Schlimgen; HA Austin; J F Tisdale; P Chitkara; Thomas A Fleisher; JOHN KLIPPEL; James E Balow; Dimitrios T Boumpas
Long-term effects of combination treatment with fludarabine and low-dose pulse cyclophosphamide in patients with lupus nephritis.
Rheumatology (Oxford, England) 2007;46(6):952-6.
2007: João B Oliveira; Nicolas Bidère; Julie E Niemela; Lixin Zheng; Keiko Sakai; Cynthia P Nix; Robert L Danner; Jennifer Barb; Peter J Munson; Jennifer M Puck; Janet Dale; Stephen E Straus; Thomas A Fleisher; Michael J Lenardo
NRAS mutation causes a human autoimmune lymphoproliferative syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(21):8953-8.
2007: Deirdre O'Mahony; John C Morris; Cate Quinn; Wendy Gao; Wyndham H Wilson; Barry L Gause; Stefania Pittaluga; Sattva S Neelapu; Margaret Brown; Thomas A Fleisher; James L Gulley; Jeffrey Schlom; Robert B Nussenblatt; Paul Albert; Thomas A Davis; Israel Lowy; Mike Petrus; Thomas Waldmann; John Janik
A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):958-64.
2006: Thomas A Fleisher
Back to basics: primary immune deficiencies: windows into the immune system.
Pediatrics in review / American Academy of Pediatrics 2006;27(10):363-72.
2006: Jessica C Shand; Patrick J Mansky; Margaret V Brown; Thomas A Fleisher; CRYSTAL MACKALL
Adolescents and young adults successfully restore lymphocyte homeostasis after intensive T-cell depleting therapy for cancer.
British journal of haematology 2006;135(2):270-1.
2006: Jack J H Bleesing; Margarida M Souto-Carneiro; William J Savage; Margaret R Brown; Cynthia Martinez; Sule Yavuz; Sebastian Brenner; Richard Siegel; Mitchell E Horwitz; Peter E Lipsky; Harry L Malech; Thomas A Fleisher
Patients with chronic granulomatous disease have a reduced peripheral blood memory B cell compartment.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7096-103.
2006: V Koneti Rao; Jorge Carrasquillo; Janet K Dale; Stephen L Bacharach; Millie Whatley; Faith Dugan; Jean Tretler; Thomas A Fleisher; Jennifer M Puck; Wyndham Wilson; Elaine S Jaffe; Nilo A Avila; Clara C Chen; Stephen E Straus
Fluorodeoxyglucose positron emission tomography (FDG-PET) for monitoring lymphadenopathy in the autoimmune lymphoproliferative syndrome (ALPS).
American journal of hematology 2006;81(2):81-5.
2006: Julie E Niemela; Amy P Hsu; Thomas A Fleisher; Jennifer M Puck
Single nucleotide polymorphisms in the apoptosis receptor gene TNFRSF6.
Molecular and cellular probes 2006;20(1):21-6.
2006: John C Morris; John Janik; Jeffrey D White; Thomas A Fleisher; Margaret Brown; Mitsuru Tsudo; Carolyn K Goldman; Bonita Bryant; Mike Petrus; Lois E Top; Cathryn C Lee; Wendy Gao; Thomas Waldmann
Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(2):401-6.
2005: Thomas A Fleisher; João B Oliveira
Autoimmune lymphoproliferative syndrome.
The Israel Medical Association journal : IMAJ 2005;7(12):758-61.
2005: Hua Zhang; Kevin S Chua; Martin Guimond; Veena Kapoor; Margaret V Brown; Thomas A Fleisher; Lauren M Long; Donna Bernstein; Brenna J Hill; Daniel C Douek; Jay A Berzofsky; Charles S Carter; Elizabeth J Read; Lee Helman; CRYSTAL MACKALL
Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells.
Nature medicine 2005;11(11):1238-43.
2005: V Koneti Rao; Faith Dugan; Janet K Dale; Joie Davis; Jean Tretler; John K Hurley; Thomas A Fleisher; Jennifer M Puck; Stephen E Straus
Use of mycophenolate mofetil for chronic, refractory immune cytopenias in children with autoimmune lymphoproliferative syndrome.
British journal of haematology 2005;129(4):534-8.
2004: João B Oliveira; Thomas A Fleisher
Autoimmune lymphoproliferative syndrome.
Current opinion in allergy and clinical immunology 2004;4(6):497-503.
2004: Jordan S Orange; Ofer Levy; Scott Brodeur; Konrad Krzewski; Rene M Roy; Julie E Niemela; Thomas A Fleisher; Francisco A Bonilla; Raif S Geha
Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia.
The Journal of allergy and clinical immunology 2004;114(3):650-6.
2004: Thomas A Fleisher; João B Oliveira
Functional and molecular evaluation of lymphocytes.
The Journal of allergy and clinical immunology 2004;114(2):227-34; quiz 235.
2003: Mindy Anderson-Cohen; Steven M Holland; Douglas B Kuhns; Thomas A Fleisher; Li Ding; Sebastian Brenner; Harry L Malech; Joachim Roesler
Severe phenotype of chronic granulomatous disease presenting in a female with a de novo mutation in gp91-phox and a non familial, extremely skewed X chromosome inactivation.
Clinical immunology (Orlando, Fla.) 2003;109(3):308-17.
2003: Kazuki Takada; Carol L Danning; Takashi Kuroiwa; Ryan Schlimgen; Ioannis Tassiulas; John C Davis; Cheryl H Yarboro; Thomas A Fleisher; Dimitrios T Boumpas; Gabor G Illei
Lymphocyte depletion with fludarabine in patients with psoriatic arthritis: clinical and immunological effects.
Annals of the rheumatic diseases 2003;62(11):1112-5.
2003: Linda Muul; Laura M Tuschong; Sherry Lau Soenen; G Jayashree Jagadeesh; W Jay Ramsey; Zhifeng Long; Charles S Carter; Elizabeth K Garabedian; Melinna Alleyne; Margaret Brown; Wendy Bernstein; Shepherd H Schurman; Thomas A Fleisher; Susan F Leitman; Cynthia E Dunbar; R. Michael Blaese; Fabio Candotti
Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial.
Blood 2003;101(7):2563-9.
2003: Thomas A Fleisher
Evaluation of suspected immunodeficiency.
MLO: medical laboratory observer 2003;35(2):10-4, 19; quiz 20-1.
2003: Orathai Jirapongsananuruk; Harry L Malech; Douglas B Kuhns; Julie E Niemela; Margaret R Brown; Mindy Anderson-Cohen; Thomas A Fleisher
Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay.
The Journal of allergy and clinical immunology 2003;111(2):374-9.
2003: Jack J H Bleesing; Thomas A Fleisher
Human B cells express a CD45 isoform that is similar to murine B220 and is downregulated with acquisition of the memory B-cell marker CD27.
Cytometry. Part B, Clinical cytometry 2003;51(1):1-8.
2003: Jack J H Bleesing; John Janik; Thomas A Fleisher
Common expression of an unusual CD45 isoform on T cells from patients with large granular lymphocyte leukaemia and autoimmune lymphoproliferative syndrome.
British journal of haematology 2003;120(1):93-6.
2002: Jack J H Bleesing; Thomas A Fleisher
Immune thrombocytopenic purpura.
The New England journal of medicine 2002;347(6):449-50; author reply 449-50.
2002: Orathai Jirapongsananuruk; Julie E Niemela; Harry L Malech; Thomas A Fleisher
CYBB mutation analysis in X-linked chronic granulomatous disease.
Clinical immunology (Orlando, Fla.) 2002;104(1):73-6.
2002: Jack J H Bleesing; Margaret R Brown; Cynthia Novicio; David L Guarraia; Janet K Dale; Stephen E Straus; Thomas A Fleisher
A composite picture of TcR alpha/beta(+) CD4(-)CD8(-) T Cells (alpha/beta-DNTCs) in humans with autoimmune lymphoproliferative syndrome.
Clinical immunology (Orlando, Fla.) 2002;104(1):21-30.
2001: David M Frucht; Massimo Gadina; G Jayashree Jagadeesh; Ivona Aksentijevich; K Takada; Jack J H Bleesing; J Nelson; Linda Muul; G Perham; G Morgan; E J Gerritsen; R Fabian Schumacher; Patrizia Mella; P A Veys; Thomas A Fleisher; E R Kaminski; Luigi D Notarangelo; John O'Shea; Fabio Candotti
Unexpected and variable phenotypes in a family with JAK3 deficiency.
Genes and immunity 2001;2(8):422-32.
2001: Thomas A Fleisher; Stephen E Straus; Jack J H Bleesing
A genetic disorder of lymphocyte apoptosis involving the fas pathway: the autoimmune lymphoproliferative syndrome.
Current allergy and asthma reports 2001;1(6):534-40.
2001: Jack J H Bleesing; Margaret R Brown; Stephen E Straus; Janet K Dale; Richard Siegel; M Johnson; Michael J Lenardo; Jennifer M Puck; Thomas A Fleisher
Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome.
Blood 2001;98(8):2466-73.
2001: Jack J H Bleesing; M R Morrow; Gulbu Uzel; Thomas A Fleisher
Human T cell activation induces the expression of a novel CD45 isoform that is analogous to murine B220 and is associated with altered O-glycan synthesis and onset of apoptosis.
Cellular immunology 2001;213(1):72-81.
2001: Iain B McInnes; Gabor G Illei; Carol L Danning; Cheryl H Yarboro; M Crane; Takashi Kuroiwa; Ryan Schlimgen; E Lee; Barbara Foster; D Flemming; Calman Prussin; Thomas A Fleisher; Dimitrios T Boumpas
IL-10 improves skin disease and modulates endothelial activation and leukocyte effector function in patients with psoriatic arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):4075-82.
2001: Jack J H Bleesing; Margaret R Brown; Janet K Dale; Stephen E Straus; Michael J Lenardo; Jennifer M Puck; T Prescott Atkinson; Thomas A Fleisher
TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis.
Clinical immunology (Orlando, Fla.) 2001;100(3):314-24.
2001: Gulbu Uzel; David M Frucht; Thomas A Fleisher; Steven M Holland
Detection of intracellular phosphorylated STAT-4 by flow cytometry.
Clinical immunology (Orlando, Fla.) 2001;100(3):270-6.
2001: Stephen E Straus; Elaine S Jaffe; Jennifer M Puck; Janet K Dale; Keith B Elkon; Angela Rösen-Wolff; A M Peters; michael sneller; Claire W Hallahan; Juehu Wang; Roxanne E Fischer; C M Jackson; Albert Y Lin; Caroline Bäumler; E Siegert; A Marx; AK Vaishnaw; Tamara Grodzicky; Thomas A Fleisher; Michael J Lenardo
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.
Blood 2001;98(1):194-200.
2001: Uri Lopatin; X Yao; R K Williams; Jack J H Bleesing; Janet K Dale; D Wong; Julie T Feldstein; S Fritz; M R Morrow; Ivan J Fuss; michael sneller; M Raffeld; Thomas A Fleisher; Jennifer M Puck; W Strober; E S Jaffe; Stephen E Straus
Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression.
Blood 2001;97(10):3161-70.
2001: Jack J H Bleesing; Thomas A Fleisher
Cell function-based flow cytometry.
Seminars in hematology 2001;38(2):169-78.
2001: Jack J H Bleesing; Thomas A Fleisher
Immunophenotyping.
Seminars in hematology 2001;38(2):100-10.
2001: G E Marti; Maryalice Stetler-Stevenson; Jack J H Bleesing; Thomas A Fleisher
Introduction to flow cytometry.
Seminars in hematology 2001;38(2):93-9.
2001: Thomas A Fleisher; Jennifer M Puck; W Strober; Janet K Dale; Michael J Lenardo; Richard Siegel; Stephen E Straus; Jack J H Bleesing
The autoimmune lymphoproliferative syndrome. A disorder of human lymphocyte apoptosis.
Clinical reviews in allergy & immunology 2001;20(1):109-20.
2000: Jack J H Bleesing; Stephen E Straus; Thomas A Fleisher
Autoimmune lymphoproliferative syndrome. A human disorder of abnormal lymphocyte survival.
Pediatric clinics of North America 2000;47(6):1291-310.
2000: Thomas A Fleisher; Jack J H Bleesing
Immune function.
Pediatric clinics of North America 2000;47(6):1197-209.
2000: Julie E Niemela; Jennifer M Puck; Roxanne E Fischer; Thomas A Fleisher; Amy P Hsu
Efficient detection of thirty-seven new IL2RG mutations in human X-linked severe combined immunodeficiency.
Clinical immunology (Orlando, Fla.) 2000;95(1 Pt 1):33-8.
2000: Nicole L Simone; A T Remaley; Lu Charboneau; Emanuel F Petricoin; J W Glickman; Michael R Emmert-Buck; Thomas A Fleisher; Lance A Liotta
Sensitive immunoassay of tissue cell proteins procured by laser capture microdissection.
The American journal of pathology 2000;156(2):445-52.
1999: Dimitrios T Boumpas; Ioannis Tassiulas; Thomas A Fleisher; E Vaughan; S Piscitelli; Y Kim; Frank Pucino; James E Balow; HA Austin
A pilot study of low-dose fludarabine in membranous nephropathy refractory to therapy.
Clinical nephrology 1999;52(2):67-75.
1999: Richard Siegel; Thomas A Fleisher
The role of Fas and related death receptors in autoimmune and other disease states.
The Journal of allergy and clinical immunology 1999;103(5 Pt 1):729-38.
1999: CE Jackson; Roxanne E Fischer; Amy P Hsu; Stacie M Anderson; Y Choi; Juehu Wang; Janet K Dale; Thomas A Fleisher; Lindsay Middelton; michael sneller; Michael J Lenardo; Stephen E Straus; Jennifer M Puck
Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance.
American journal of human genetics 1999;64(4):1002-14.
1999: Thomas A Fleisher; Susan E Dorman; J A Anderson; M Vail; Margaret R Brown; S M Holland
Detection of intracellular phosphorylated STAT-1 by flow cytometry.
Clinical immunology (Orlando, Fla.) 1999;90(3):425-30.
1999: Cynthia Dunbar; L Chang; Craig A Mullen; W J Ramsey; Charles Carter; D Kohn; Robertson Parkman; Carl Lenarsky; Kenneth I Weinberg; Diane Wara; KW Culver; W F Anderson; Susan F Leitman; Thomas A Fleisher; HARVEY KLEIN; G Shearer; Mario Clerici; GJ McGarrity; John Bastian; Michael S Hershfield
Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene.
Human gene therapy 1999;10(3):477-88.
1999: EM Adams; Frank Pucino; Cheryl H Yarboro; Jeanne E Hicks; B Thornton; C McGarvey; Barbara C Sonies; ML Bartlett; ML Villalba; Thomas A Fleisher; Paul H Plotz
A pilot study: use of fludarabine for refractory dermatomyositis and polymyositis, and examination of endpoint measures.
The Journal of rheumatology 1999;26(2):352-60.
1998: F M Foss; A Raubitscheck; James L Mulshine; Thomas A Fleisher; James C Reynolds; Chang H Paik; Ronald D Neumann; C Boland; P Perentesis; M R Brown; J M Frincke; C P Lollo; Steven M Larson; Jorge Carrasquillo
Phase I study of the pharmacokinetics of a radioimmunoconjugate, 90Y-T101, in patients with CD5-expressing leukemia and lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(11):2691-700.
1998: Anthony Infante; H A Britton; Thomas S DeNapoli; Lindsay Middelton; Michael J Lenardo; CE Jackson; Juehu Wang; Thomas A Fleisher; Stephen E Straus; Jennifer M Puck
The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis.
The Journal of pediatrics 1998;133(5):629-33.
1998: Megan S Lim; Stephen E Straus; Janet K Dale; Thomas A Fleisher; Maryalice Stetler-Stevenson; W Strober; michael sneller; Jennifer M Puck; Michael J Lenardo; Kojo Seys John Elenitoba-Johnson; Albert Y Lin; Mark Raffeld; Elaine S Jaffe
Pathological findings in human autoimmune lymphoproliferative syndrome.
The American journal of pathology 1998;153(5):1541-50.
1998: Steven M Holland; Susan E Dorman; A Kwon; I F Pitha-Rowe; David M Frucht; S M Gerstberger; G J Noel; P Vesterhus; Margaret R Brown; Thomas A Fleisher
Abnormal regulation of interferon-gamma, interleukin-12, and tumor necrosis factor-alpha in human interferon-gamma receptor 1 deficiency.
The Journal of infectious diseases 1998;178(4):1095-104.
1998: John C Davis; B J Fessler; Ioannis Tassiulas; Iain B McInnes; Cheryl H Yarboro; Stanley R Pillemer; Ronald L Wilder; Thomas A Fleisher; JOHN KLIPPEL; Dimitrios T Boumpas
High dose versus low dose fludarabine in the treatment of patients with severe refractory rheumatoid arthritis.
The Journal of rheumatology 1998;25(9):1694-704.
1998: Ilia Elenkov; Elizabeth Webster; Dimitris A Papanicolaou; Thomas A Fleisher; George Chrousos; Ronald L Wilder
Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2586-93.
1998: John C Davis; HA Austin; Dimitrios T Boumpas; Thomas A Fleisher; Cheryl H Yarboro; A Larson; James E Balow; JOHN KLIPPEL; D Scott
A pilot study of 2-chloro-2'-deoxyadenosine in the treatment of systemic lupus erythematosus-associated glomerulonephritis.
Arthritis and rheumatism 1998;41(2):335-43.
1997: Roscoe O Brady; Gary J Murray; KL Oliver; S F Leitman; michael sneller; Thomas A Fleisher; Norman W Barton
Management of neutralizing antibody to Ceredase in a patient with type 3 Gaucher disease.
Pediatrics 1997;100(6):E11.
1997: Harry L Malech; P B Maples; Narda L Whiting-Theobald; Gilda F Linton; S Sekhsaria; S J Vowells; F Li; J A Miller; Ellen S DeCarlo; Steven M Holland; Susan F Leitman; C S Carter; R E Butz; E J Read; Thomas A Fleisher; R D Schneiderman; D E Van Epps; SK Spratt; C A Maack; Joseph Rokovich; LK Cohen; John Gallin
Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):12133-8.
1997: Thomas A Fleisher
Immune function.
Pediatrics in review / American Academy of Pediatrics 1997;18(10):351-6.
1997: CRYSTAL MACKALL; Thomas A Fleisher; M R Brown; M P Andrich; C C Chen; I M Feuerstein; Ian Magrath; Leonard H Wexler; D S Dimitrov; Ronald E Gress
Distinctions between CD8+ and CD4+ T-cell regenerative pathways result in prolonged T-cell subset imbalance after intensive chemotherapy.
Blood 1997;89(10):3700-7.
1997: michael sneller; Juehu Wang; Janet K Dale; W Strober; Lindsay Middelton; Y Choi; Thomas A Fleisher; Megan S Lim; E S Jaffe; Jennifer M Puck; Michael J Lenardo; Stephen E Straus
Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.
Blood 1997;89(4):1341-8.
1997: T A Selvaggi; Robert E Walker; Thomas A Fleisher
Development of antibodies to fetal calf serum with arthus-like reactions in human immunodeficiency virus-infected patients given syngeneic lymphocyte infusions.
Blood 1997;89(3):776-9.
1996: S Sekhsaria; Thomas A Fleisher; S Vowells; M Brown; J Miller; I Gordon; R. Michael Blaese; Cynthia E Dunbar; Susan F Leitman; Harry L Malech
Granulocyte colony-stimulating factor recruitment of CD34+ progenitors to peripheral blood: impaired mobilization in chronic granulomatous disease and adenosine deaminase--deficient severe combined immunodeficiency disease patients.
Blood 1996;88(3):1104-12.
1996: S J Vowells; Thomas A Fleisher; Harry L Malech
Testing for chronic granulomatous disease.
Lancet 1996;347(9007):1048-9.
1996: S J Vowells; Thomas A Fleisher; S Sekhsaria; D W Alling; T E Maguire; Harry L Malech
Genotype-dependent variability in flow cytometric evaluation of reduced nicotinamide adenine dinucleotide phosphate oxidase function in patients with chronic granulomatous disease.
The Journal of pediatrics 1996;128(1):104-7.
1995: Thomas Waldmann; Jeffrey D White; Jorge Carrasquillo; James C Reynolds; Chang H Paik; Otto A Gansow; Martin W Brechbiel; Elaine S Jaffe; Thomas A Fleisher; Carolyn K Goldman; Lois E Top; RN Bamford; E Zaknoen; E Roessler; C Kasten-Sportes; R England; H Litou; J A Johnson; T Jackson-White; Angela Manns; Barrie Hanchard; Richard P. Junghans; David L Nelson
Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac.
Blood 1995;86(11):4063-75.
1995: R. Michael Blaese; KW Culver; A D Miller; Charles S Carter; Thomas A Fleisher; M Clerici; G Shearer; L Chang; Y Chiang; P Tolstoshev; J J Greenblatt; STEVEN ROSENBERG; HARVEY KLEIN; M Berger; Craig A Mullen; W J Ramsey; L Muul; Richard A Morgan; W French Anderson
T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years.
Science (New York, N.Y.) 1995;270(5235):475-80.
1995: CRYSTAL MACKALL; Thomas A Fleisher; M R Brown; M P Andrich; Clara C Chen; IM Feuerstein; M E Horowitz; Ian Magrath; Aziza T Shad; Seth M Steinberg
Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy.
The New England journal of medicine 1995;332(3):143-9.
1995: S J Vowells; S Sekhsaria; Harry L Malech; M Shalit; Thomas A Fleisher
Flow cytometric analysis of the granulocyte respiratory burst: a comparison study of fluorescent probes.
Journal of immunological methods 1995;178(1):89-97.
1994: CRYSTAL MACKALL; Thomas A Fleisher; M R Brown; Ian Magrath; Aziza T Shad; M E Horowitz; Leonard H Wexler; MA Adde; L L McClure; Ronald E Gress
Lymphocyte depletion during treatment with intensive chemotherapy for cancer.
Blood 1994;84(7):2221-8.
1994: Steven M Holland; E M Eisenstein; D B Kuhns; M L Turner; Thomas A Fleisher; W Strober; John Gallin
Treatment of refractory disseminated nontuberculous mycobacterial infection with interferon gamma. A preliminary report.
The New England journal of medicine 1994;330(19):1348-55.
1993: Thomas A Fleisher; R. Michael Blaese
New approaches in the therapy of immunodeficiency.
Allergy proceedings : the official journal of regional and state allergy societies 1993;14(6):409-11.
1992: P H Carter; S Resto-Ruiz; G C Washington; S Ethridge; A Palini; R Vogt; M Waxdal; Thomas A Fleisher; P D Noguchi; Gerald E Marti
Flow cytometric analysis of whole blood lysis, three anticoagulants, and five cell preparations.
Cytometry 1992;13(1):68-74.
1991: KW Culver; W R Osborne; A D Miller; Thomas A Fleisher; M Berger; W French Anderson; R. Michael Blaese
Correction of ADA deficiency in human T lymphocytes using retroviral-mediated gene transfer.
Transplantation proceedings 1991;23(1 Pt 1):170-1.
1990: J J Wright; D K Wagner; R. Michael Blaese; C Hagengruber; Thomas Waldmann; Thomas A Fleisher
Characterization of common variable immunodeficiency: identification of a subset of patients with distinctive immunophenotypic and clinical features.
Blood 1990;76(10):2046-51.
1990: C L Tendler; S J Greenberg; William A Blattner; Angela Manns; E Murphy; Thomas A Fleisher; Barrie Hanchard; Owen Morgan; J D Burton; David L Nelson
Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5218-22.
1989: D K Wagner; G E Marti; E S Jaffe; S E Straus; David L Nelson; Thomas A Fleisher
Lymphocyte analysis in a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency after development of echovirus dermatomyositis and meningoencephalitis.
International archives of allergy and applied immunology 1989;89(2-3):143-8.
1988: Thomas A Fleisher; Gerald E Marti; C Hagengruber
Two-color flow cytometric analysis of monocyte depleted human blood lymphocyte subsets.
Cytometry 1988;9(4):309-15.
1988: M J Waxdal; M C Monical; Thomas A Fleisher; G E Marti
Inter-laboratory survey of lymphocyte immunophenotyping.
Pathology and immunopathology research 1988;7(5):345-56.
1988: Gerald E Marti; Thomas A Fleisher
Application of lymphocyte immunophenotyping in selected diseases.
Pathology and immunopathology research 1988;7(5):319-37.
1988: Thomas A Fleisher; C Hagengruber; Gerald E Marti
Immunophenotyping of normal lymphocytes.
Pathology and immunopathology research 1988;7(5):305-18.
1987: J J Wright; D L Birx; D K Wagner; Thomas Waldmann; R. Michael Blaese; Thomas A Fleisher
Normalization of antibody responsiveness in a patient with common variable hypogammaglobulinemia and HIV infection.
The New England journal of medicine 1987;317(24):1516-20.