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Helen Fletcher

Research Profile

Chemicals & Drugs

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Tuberculosis

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Publications

TOP 3
Joel Meyer; Ian D Poulton; Hazel C Poyntz; Rosalind Rowland; Iman Satti; Rachel Tanner; Helen A Fletcher; Kristin L Griffiths; Stephanie A Harris; Helen McShane
Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery.
George M Warimwe; Philip Bejon; Helen A Fletcher; Adrian V S Hill; Gathoni Kamuyu; Linda M Murungi; Vivek Naranbhai; George M Nyangweso; F H A Osier; Juliana Wambua; Kevin Marsh
The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children.
Ansar A Pathan; David W Porter; Ian D Poulton; Rosalind Rowland; Clare R Sander; Helen A Fletcher; Adrian V S Hill; Angela M Minassian; Helen McShane
Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults.

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All Publications

2013: Joel Meyer; Ian D Poulton; Hazel C Poyntz; Rosalind Rowland; Iman Satti; Rachel Tanner; Helen A Fletcher; Kristin L Griffiths; Stephanie A Harris; Helen McShane
Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery.
Vaccine 2013;31(7):1026-33.
2013: George M Warimwe; Philip Bejon; Helen A Fletcher; Adrian V S Hill; Gathoni Kamuyu; Linda M Murungi; Vivek Naranbhai; George M Nyangweso; F H A Osier; Juliana Wambua; Kevin Marsh
The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children.
PloS one 2013;8(2):e57320.
2012: Ansar A Pathan; David W Porter; Ian D Poulton; Rosalind Rowland; Clare R Sander; Helen A Fletcher; Adrian V S Hill; Angela M Minassian; Helen McShane
Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults.
Vaccine 2012;30(38):5616-24.
2011: Angela M Minassian; Ansar A Pathan; Ian D Poulton; Hazel Poyntz; David A Price; Mario Roederer; Guy Rooney; Jonathan Ross; Rosalind Rowland; Clare R Sander; Iman Satti; Jackie Sherrard; Nicola Williams; Alan Winston; David R Ambrozak; Natalie E R Beveridge; Joseph P Casazza; Daniel C Douek; Helen A Fletcher; Kristin Griffiths; Matthew Hamill; Stephanie Harris; Brenna J Hill; Richard A Koup; Alison M Lawrie; Helen McShane
A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults.
BMJ open 2011;1(2):e000223.
2011: Kristin L Griffiths; Adrian V S Hill; Natalie E R Beveridge; Helen A Fletcher; Angela M Minassian; Ansar A Pathan; Clare R Sander; Helen McShane
Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A.
PloS one 2011;6(8):e23463.
2011: Tamara K Berthoud; Matthew Hamill; Patrick J Lillie; Lenias Hwenda; Katharine A Collins; Katie Ewer; Anita Milicic; Hazel C Poyntz; Teresa Lambe; Helen A Fletcher; Adrian V S Hill; Sarah Gilbert
Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011;52(1):1-7.
2010: Simone C de Cassan; Ansar A Pathan; Clare R Sander; Angela Minassian; Rosalind Rowland; Adrian V S Hill; Helen McShane; Helen A Fletcher
Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A.
Clinical and vaccine immunology : CVI 2010;17(7):1066-73.
2010: Susanna Dunachie; Tamara Berthoud; Sheila Keating; Adrian V S Hill; Helen A Fletcher
MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy.
PloS one 2010;5(9):e12557.
2008: Natalie E R Beveridge; Helen A Fletcher; Jane Hughes; Ansar A Pathan; Thomas J Scriba; Angela Minassian; Clare R Sander; Kathryn T Whelan; Hazel M Dockrell; Adrian V S Hill; Willem A Hanekom; Helen McShane
A comparison of IFNgamma detection methods used in tuberculosis vaccine trials.
Tuberculosis (Edinburgh, Scotland) 2008;88(6):631-40.
2008: Helen A Fletcher; Ansar A Pathan; Tamara K Berthoud; Susanna Dunachie; Kathryn T Whelan; Nicola C Alder; Clare R Sander; Adrian V S Hill; Helen McShane
Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.
Vaccine 2008;26(41):5269-75.
2008: Roger H Brookes; Philip C Hill; Patrick K Owiafe; Hannah B Ibanga; David J Jeffries; Simon A Donkor; Helen A Fletcher; Abdulrahman Hammond; Christian Lienhardt; Richard A Adegbola; Helen McShane; Adrian V S Hill
Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa.
PloS one 2008;3(8):e2921.
2007: Helen A Fletcher
Correlates of immune protection from tuberculosis.
Current molecular medicine 2007;7(3):319-25.
2007: Ansar A Pathan; Clare R Sander; Helen A Fletcher; Ian Poulton; Nicola C Alder; Natalie E R Beveridge; Kathryn T Whelan; Adrian V S Hill; Helen McShane
Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials.
PloS one 2007;2(10):e1052.
2006: Hannah B Ibanga; Roger H Brookes; Philip C Hill; Patrick K Owiafe; Helen A Fletcher; Christian Lienhardt; Adrian V S Hill; Richard A Adegbola; Helen McShane
Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design.
The Lancet infectious diseases 2006;6(8):522-8.
2005: Helen McShane; Ansar A Pathan; Clare R Sander; Nilu Goonetilleke; Helen A Fletcher; Adrian V S Hill
Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials.
Tuberculosis (Edinburgh, Scotland) 2005;85(1-2):47-52.
2004: Helen McShane; Ansar A Pathan; Clare R Sander; Sheila Keating; Sarah Gilbert; Kris Huygen; Helen A Fletcher; Adrian V S Hill
Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans.
Nature medicine 2004;10(11):1240-4.
2004: Helen A Fletcher; Patrick K Owiafe; David J Jeffries; Philip Hill; Graham Rook; Alimuddin Zumla; T Mark Doherty; Roger H Brookes
Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.
Immunology 2004;112(4):669-73.