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Robert Fletterick

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Vinogradova Maia V; Malanina Galina G; Reddy Anireddy S N; Fletterick Robert J
Structure of the complex of a mitotic kinesin with its calcium binding regulator.
Jouravel Natalia; Sablin Elena; Togashi Marie; Baxter John D; Webb Paul; Fletterick Robert J
Molecular basis for dimer formation of TRbeta variant D355R.
Sablin Elena P; Blind Raymond D; Krylova Irina N; Ingraham Jared G; Cai Fang; Williams Jon D; Fletterick Robert J; Ingraham Holly A
Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.

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All Publications

2009: Vinogradova Maia V; Malanina Galina G; Reddy Anireddy S N; Fletterick Robert J
Structure of the complex of a mitotic kinesin with its calcium binding regulator.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(20):8175-9.
2009: Jouravel Natalia; Sablin Elena; Togashi Marie; Baxter John D; Webb Paul; Fletterick Robert J
Molecular basis for dimer formation of TRbeta variant D355R.
Proteins 2009;75(1):111-7.
2009: Sablin Elena P; Blind Raymond D; Krylova Irina N; Ingraham Jared G; Cai Fang; Williams Jon D; Fletterick Robert J; Ingraham Holly A
Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.
Molecular endocrinology (Baltimore, Md.) 2009;23(1):25-34.
2008: Sablin Elena P; Woods April; Krylova Irina N; Hwang Peter; Ingraham Holly A; Fletterick Robert J
The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18390-5.
2008: Wilbur Jeremy D; Chen Chih-Ying; Manalo Venus; Hwang Peter K; Fletterick Robert J; Brodsky Frances M
Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.
The Journal of biological chemistry 2008;283(47):32870-9.
2008: Cruz Leslie A; Estébanez-Perpiñá Eva; Pfaff Sam; Borngraeber Sabine; Bao Ning; Blethrow Justin; Fletterick Robert J; England Pamela M
6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor.
Journal of medicinal chemistry 2008;51(18):5856-60.
2008: Vinogradova Maia V; Malanina Galina G; Reddy Vaka S; Reddy Anireddy S N; Fletterick Robert J
Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein.
Journal of structural biology 2008;163(1):76-83.
2007: Estébanez-Perpiñá Eva; Arnold Leggy A; Jouravel Natalia; Togashi Marie; Blethrow Justin; Mar Ellena; Nguyen Phuong; Phillips Kevin J; Baxter John D; Webb Paul; Guy R Kiplin; Fletterick Robert J
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(12):2919-28.
2007: Jouravel Natalia; Sablin Elena; Arnold Leggy A; Guy R Kiplin; Fletterick Robert J
Interaction between the androgen receptor and a segment of its corepressor SHP.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 11):1198-200.
2007: Arnold Leggy A; Kosinski Aaron; Estébanez-Perpiñá Eva; Fletterick Robert J; Guy R Kiplin
Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships.
Journal of medicinal chemistry 2007;50(22):5269-80.
2007: Estébanez-Perpiñá Eva; Arnold Leggy A; Nguyen Phuong; Rodrigues Edson Delgado; Mar Ellena; Bateman Raynard; Pallai Peter; Shokat Kevan M; Baxter John D; Guy R Kiplin; Webb Paul; Fletterick Robert J
A surface on the androgen receptor that allosterically regulates coactivator binding.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16074-9.
2007: Wang Stephanie X; Pandey Kailash C; Scharfstein Julio; Whisstock James; Huang Rick K; Jacobelli Jordan; Fletterick Robert J; Rosenthal Philip J; Abrahamson Magnus; Brinen Linda S; Rossi Andrea; Sali Andrej; McKerrow James H
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Structure (London, England : 1993) 2007;15(5):535-43.
2007: Vinogradova Maia V; Stone Deborah B; Malanina Galina G; Mendelson Robert A; Fletterick Robert J
Ca ion and the troponin switch.
Advances in experimental medicine and biology 2007;592():47-57.
2006: Luginbühl Béatrice; Kanyo Zoltan; Jones R Mark; Fletterick Robert J; Prusiner Stanley B; Cohen Fred E; Williamson R Anthony; Burton Dennis R; Plückthun Andreas
Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.
Journal of molecular biology 2006;363(1):75-97.
2006: Wang Stephanie X; Pandey Kailash C; Somoza John R; Sijwali Puran S; Kortemme Tanja; Brinen Linda S; Fletterick Robert J; Rosenthal Philip J; McKerrow James H
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11503-8.
2006: Arnold Leggy A; Estébanez-Perpiñá Eva; Togashi Marie; Shelat Anang; Ocasio Cory A; McReynolds Andrea C; Nguyen Phuong; Baxter John D; Fletterick Robert J; Webb Paul; Guy R Kiplin
A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding.
Science's STKE : signal transduction knowledge environment 2006;2006(341):pl3.
2006: Blumenschein Tharin M A; Stone Deborah B; Fletterick Robert J; Mendelson Robert A; Sykes Brian D
Dynamics of the C-terminal region of TnI in the troponin complex in solution.
Biophysical journal 2006;90(7):2436-44.
2006: Pirani Alnoor; Vinogradova Maia V; Curmi Paul M G; King William A; Fletterick Robert J; Craig Roger; Tobacman Larry S; Xu Chen; Hatch Victoria; Lehman William
An atomic model of the thin filament in the relaxed and Ca2+-activated states.
Journal of molecular biology 2006;357(3):707-17.
2005: Fletterick Robert J
Molecular modelling of the androgen receptor axis: rational basis for androgen receptor intervention in androgen-independent prostate cancer.
BJU international 2005;96 Suppl 2():2-9.
2005: Arnold Leggy A; Estébanez-Perpiñá Eva; Togashi Marie; Jouravel Natalia; Shelat Anang; McReynolds Andrea C; Mar Ellena; Nguyen Phuong; Baxter John D; Fletterick Robert J; Webb Paul; Guy R Kiplin
Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators.
The Journal of biological chemistry 2005;280(52):43048-55.
2005: Togashi Marie; Nguyen Phuong; Fletterick Robert; Baxter John D; Webb Paul
Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation.
The Journal of biological chemistry 2005;280(27):25665-73.
2005: Blumenschein Tharin M A; Stone Deborah B; Fletterick Robert J; Mendelson Robert A; Sykes Brian D
Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex.
The Journal of biological chemistry 2005;280(23):21924-32.
2005: Vinogradova Maia V; Stone Deborah B; Malanina Galina G; Karatzaferi Christina; Cooke Roger; Mendelson Robert A; Fletterick Robert J
Ca(2+)-regulated structural changes in troponin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):5038-43.
2005: Estébanez-Perpiñá Eva; Moore Jamie M R; Mar Ellena; Delgado-Rodrigues Edson; Nguyen Phuong; Baxter John D; Buehrer Benjamin M; Webb Paul; Fletterick Robert J; Guy R Kiplin
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.
The Journal of biological chemistry 2005;280(9):8060-8.
2005: Togashi Marie; Borngraeber Sabine; Sandler Ben; Fletterick Robert J; Webb Paul; Baxter John D
Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design.
The Journal of steroid biochemistry and molecular biology 2005;93(2-5):127-37.
2005: Krylova Irina N; Sablin Elena P; Moore Jamie; Xu Robert X; Waitt Gregory M; MacKay J Andrew; Juzumiene Dalia; Bynum Jane M; Madauss Kevin; Montana Valerie; Lebedeva Lioudmila; Suzawa Miyuki; Williams Jon D; Williams Shawn P; Guy Rodney K; Thornton Joseph W; Fletterick Robert J; Willson Timothy M; Ingraham Holly A
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Cell 2005;120(3):343-55.
2004: Sandler Ben; Webb Paul; Apriletti James W; Huber B Russell; Togashi Marie; Cunha Lima Suzana T; Juric Sanja; Nilsson Stefan; Wagner Richard; Fletterick Robert J; Baxter John D
Thyroxine-thyroid hormone receptor interactions.
The Journal of biological chemistry 2004;279(53):55801-8.
2004: Hur Eugene; Pfaff Samuel J; Payne E Sturgis; Grøn Hanne; Buehrer Benjamin M; Fletterick Robert J
Recognition and accommodation at the androgen receptor coactivator binding interface.
PLoS biology 2004;2(9):E274.
2004: Ruggles Sandra Waugh; Fletterick Robert J; Craik Charles S
Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity.
The Journal of biological chemistry 2004;279(29):30751-9.
2004: Vinogradova Maia V; Reddy Vaka S; Reddy Anireddy S N; Sablin Elena P; Fletterick Robert J
Crystal structure of kinesin regulated by Ca(2+)-calmodulin.
The Journal of biological chemistry 2004;279(22):23504-9.
2004: Shipley Krista; Hekmat-Nejad Mohammad; Turner Jennifer; Moores Carolyn; Anderson Robert; Milligan Ronald; Sakowicz Roman; Fletterick Robert
Structure of a kinesin microtubule depolymerization machine.
The EMBO journal 2004;23(7):1422-32.
2004: Sablin Elena P; Fletterick Robert J
Coordination between motor domains in processive kinesins.
The Journal of biological chemistry 2004;279(16):15707-10.
2003: Borngraeber Sabine; Budny Mary-Jane; Chiellini Grazia; Cunha-Lima Suzana T; Togashi Marie; Webb Paul; Baxter John D; Scanlan Thomas S; Fletterick Robert J
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15358-63.
2003: Wang Stephanie X; Hur Eugene; Sousa Carolyn A; Brinen Linda; Slivka Eric J; Fletterick Robert J
The extended interactions and Gla domain of blood coagulation factor Xa.
Biochemistry 2003;42(26):7959-66.
2003: Bell Jessica K; Goetz David H; Mahrus Sami; Harris Jennifer L; Fletterick Robert J; Craik Charles S
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
Nature structural biology 2003;10(7):527-34.
2003: Sablin Elena P; Krylova Irina N; Fletterick Robert J; Ingraham Holly A
Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1.
Molecular cell 2003;11(6):1575-85.
2003: Huber B Russell; Sandler Ben; West Brian L; Cunha Lima Suzana T; Nguyen Hoa T; Apriletti James W; Baxter John D; Fletterick Robert J
Two resistance to thyroid hormone mutants with impaired hormone binding.
Molecular endocrinology (Baltimore, Md.) 2003;17(4):643-52.
2003: Huber B Russell; Desclozeaux Marion; West Brian L; Cunha-Lima Suzana T; Nguyen Hoa T; Baxter John D; Ingraham Holly A; Fletterick Robert J
Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain.
Molecular endocrinology (Baltimore, Md.) 2003;17(1):107-16.
2003: Dawson John F; Sablin Elena P; Spudich James A; Fletterick Robert J
Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing.
The Journal of biological chemistry 2003;278(2):1229-38.
2002: Webb Paul; Nguyen Ngoc-Ha; Chiellini Grazia; Yoshihara Hikari A I; Cunha Lima Suzana T; Apriletti James W; Ribeiro Ralff C J; Marimuthu Adhirai; West Brian L; Goede Patrick; Mellstrom Karin; Nilsson Stefan; Kushner Peter J; Fletterick Robert J; Scanlan Thomas S; Baxter John D
Design of thyroid hormone receptor antagonists from first principles.
The Journal of steroid biochemistry and molecular biology 2002;83(1-5):59-73.
2002: Sindelar Charles V; Budny Mary Jane; Rice Sarah; Naber Nariman; Fletterick Robert; Cooke Roger
Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy.
Nature structural biology 2002;9(11):844-8.
2002: Desclozeaux Marion; Krylova Irina N; Horn Florence; Fletterick Robert J; Ingraham Holly A
Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.
Molecular and cellular biology 2002;22(20):7193-203.
2002: Ekstrom Jennifer L; Pauly Thomas A; Carty Maynard D; Soeller Walter C; Culp Jeff; Danley Dennis E; Hoover Dennis J; Treadway Judith L; Gibbs E Michael; Fletterick Robert J; Day Yasmina S N; Myszka David G; Rath Virginia L
Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chemistry & biology 2002;9(8):915-24.
2002: Sablin Elena P; Dawson John F; VanLoock Margaret S; Spudich James A; Egelman Edward H; Fletterick Robert J
How does ATP hydrolysis control actin's associations?
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):10945-7.
2002: Walther Matthias; Anton Monika; Wiedmann Martin; Fletterick Robert; Kuhn Hartmut
The N-terminal domain of the reticulocyte-type 15-lipoxygenase is not essential for enzymatic activity but contains determinants for membrane binding.
The Journal of biological chemistry 2002;277(30):27360-6.
2002: Laboissière Martha C A; Young Malin M; Pinho Rilva G; Todd Stephen; Fletterick Robert J; Kuntz Irwin; Craik Charles S
Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition.
The Journal of biological chemistry 2002;277(29):26623-31.
2002: Marimuthu Adhirai; Feng Weijun; Tagami Tetsuya; Nguyen Hoa; Jameson J Larry; Fletterick Robert J; Baxter John D; West Brian L
TR surfaces and conformations required to bind nuclear receptor corepressor.
Molecular endocrinology (Baltimore, Md.) 2002;16(2):271-86.
2002: Baxter John D; Goede Patrick; Apriletti James W; West Brian L; Feng Weijun; Mellstrom Karin; Fletterick Robert J; Wagner Richard L; Kushner Peter J; Ribeiro Ralff C J; Webb Paul; Scanlan Thomas S; Nilsson Stefan
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist.
Endocrinology 2002;143(2):517-24.
2001: Sablin E P; Fletterick R J
Nucleotide switches in molecular motors: structural analysis of kinesins and myosins.
Current opinion in structural biology 2001;11(6):716-24.
2001: Martín M A; Rubio J C; Buchbinder J; Fernández-Hojas R; del Hoyo P; Teijeira S; Gámez J; Navarro C; Fernández J M; Cabello A; Campos Y; Cervera C; Culebras J M; Andreu A L; Fletterick R; Arenas J
Molecular heterogeneity of myophosphorylase deficiency (McArdle's disease): a genotype-phenotype correlation study.
Annals of neurology 2001;50(5):574-81.
2001: Wang S X; Esmon C T; Fletterick R J
Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions.
Biochemistry 2001;40(34):10038-46.
2001: Turner J; Anderson R; Guo J; Beraud C; Fletterick R; Sakowicz R
Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.
The Journal of biological chemistry 2001;276(27):25496-502.
2001: Kikkawa M; Sablin E P; Okada Y; Yajima H; Fletterick R J; Hirokawa N
Switch-based mechanism of kinesin motors.
Nature 2001;411(6836):439-45.
2001: Eggers C T; Wang S X; Fletterick R J; Craik C S
The role of ecotin dimerization in protease inhibition.
Journal of molecular biology 2001;308(5):975-91.
2001: Ribeiro R C; Feng W; Wagner R L; Costa C H; Pereira A C; Apriletti J W; Fletterick R J; Baxter J D
Definition of the surface in the thyroid hormone receptor ligand binding domain for association as homodimers and heterodimers with retinoid X receptor.
The Journal of biological chemistry 2001;276(18):14987-95.
2001: Wagner R L; Huber B R; Shiau A K; Kelly A; Cunha Lima S T; Scanlan T S; Apriletti J W; Baxter J D; West B L; Fletterick R J
Hormone selectivity in thyroid hormone receptors.
Molecular endocrinology (Baltimore, Md.) 2001;15(3):398-410.
2001: Baxter J D; Dillmann W H; West B L; Huber R; Furlow J D; Fletterick R J; Webb P; Apriletti J W; Scanlan T S
Selective modulation of thyroid hormone receptor action.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):31-42.
2001: Kapila Y; Doan D; Tafolla E; Fletterick R
Three-dimensional structural analysis of fibronectin heparin-binding domain mutations.
Journal of cellular biochemistry. Supplement 2001;Suppl 36():156-61.
2001: Buchbinder J L; Rath V L; Fletterick R J
Structural relationships among regulated and unregulated phosphorylases.
Annual review of biophysics and biomolecular structure 2001;30():191-209.
2000: Waugh S M; Harris J L; Fletterick R; Craik C S
The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity.
Nature structural biology 2000;7(9):762-5.
2000: Brinen L S; Hansell E; Cheng J; Roush W R; McKerrow J H; Fletterick R J
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure (London, England : 1993) 2000;8(8):831-40.
2000: Gillmor S A; Takeuchi T; Yang S Q; Craik C S; Fletterick R J
Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.
Journal of molecular biology 2000;299(4):993-1003.
2000: Vale R D; Case R; Sablin E; Hart C; Fletterick R
Searching for kinesin's mechanical amplifier.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1396):449-57.
1999: Borngräber S; Browner M; Gillmor S; Gerth C; Anton M; Fletterick R; Kühn H
Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity.
The Journal of biological chemistry 1999;274(52):37345-50.
1999: Han Y; Sablin E P; Nogales E; Fletterick R J; Downing K H
Visualizing a new binding site of ncd-motor domain on tubulin.
Journal of structural biology 1999;128(1):26-33.
1999: Kanyo Z F; Pan K M; Williamson R A; Burton D R; Prusiner S B; Fletterick R J; Cohen F E
Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.
Journal of molecular biology 1999;293(4):855-63.
1999: Norman A W; Adams D; Collins E D; Okamura W H; Fletterick R J
Three-dimensional model of the ligand binding domain of the nuclear receptor for 1alpha,25-dihydroxy-vitamin D(3).
Journal of cellular biochemistry 1999;74(3):323-33.
1999: Ybe J A; Brodsky F M; Hofmann K; Lin K; Liu S H; Chen L; Earnest T N; Fletterick R J; Hwang P K
Clathrin self-assembly is mediated by a tandemly repeated superhelix.
Nature 1999;399(6734):371-5.
1999: Weatherman R V; Fletterick R J; Scanlan T S
Nuclear-receptor ligands and ligand-binding domains.
Annual review of biochemistry 1999;68():559-81.
1998: Butte M J; Hwang P K; Mobley W C; Fletterick R J
Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors.
Biochemistry 1998;37(48):16846-52.
1998: Kull F J; Vale R D; Fletterick R J
The case for a common ancestor: kinesin and myosin motor proteins and G proteins.
Journal of muscle research and cell motility 1998;19(8):877-86.
1998: Apriletti J W; Ribeiro R C; Wagner R L; Feng W; Webb P; Kushner P J; West B L; Nilsson S; Scanlan T S; Fletterick R J; Baxter J D
Molecular and structural biology of thyroid hormone receptors.
Clinical and experimental pharmacology & physiology. Supplement 1998;25():S2-11.
1998: Darimont B D; Wagner R L; Apriletti J W; Stallcup M R; Kushner P J; Baxter J D; Fletterick R J; Yamamoto K R
Structure and specificity of nuclear receptor-coactivator interactions.
Genes & development 1998;12(21):3343-56.
1998: Sablin E P; Case R B; Dai S C; Hart C L; Ruby A; Vale R D; Fletterick R J
Direction determination in the minus-end-directed kinesin motor ncd.
Nature 1998;395(6704):813-6.
1998: Focia P J; Craig S P; Nieves-Alicea R; Fletterick R J; Eakin A E
A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi.
Biochemistry 1998;37(43):15066-75.
1998: Buchbinder J L; Stephenson R C; Scanlan T S; Fletterick R J
A comparison of the crystallographic structures of two catalytic antibodies with esterase activity.
Journal of molecular biology 1998;282(5):1033-41.
1998: Collingwood T N; Wagner R; Matthews C H; Clifton-Bligh R J; Gurnell M; Rajanayagam O; Agostini M; Fletterick R J; Beck-Peccoz P; Reinhardt W; Binder G; Ranke M B; Hermus A; Hesch R D; Lazarus J; Newrick P; Parfitt V; Raggatt P; de Zegher F; Chatterjee V K
A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone.
The EMBO journal 1998;17(16):4760-70.
1998: Kull F J; Fletterick R J
Is the tubulin/FtsZ fold related to the G-protein fold?
Trends in cell biology 1998;8(8):306-7.
1998: Yang S Q; Wang C I; Gillmor S A; Fletterick R J; Craik C S
Ecotin: a serine protease inhibitor with two distinct and interacting binding sites.
Journal of molecular biology 1998;279(4):945-57.
1998: Feng W; Ribeiro R C; Wagner R L; Nguyen H; Apriletti J W; Fletterick R J; Baxter J D; Kushner P J; West B L
Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors.
Science (New York, N.Y.) 1998;280(5370):1747-9.
1998: Clifton-Bligh R J; de Zegher F; Wagner R L; Collingwood T N; Francois I; Van Helvoirt M; Fletterick R J; Chatterjee V K
A novel TR beta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation.
Molecular endocrinology (Baltimore, Md.) 1998;12(5):609-21.
1998: Ribeiro R C; Apriletti J W; Wagner R L; Feng W; Kushner P J; Nilsson S; Scanlan T S; West B L; Fletterick R J; Baxter J D
X-ray crystallographic and functional studies of thyroid hormone receptor.
The Journal of steroid biochemistry and molecular biology 1998;65(1-6):133-41.
1998: Somoza J R; Skillman A G; Munagala N R; Oshiro C M; Knegtel R M; Mpoke S; Fletterick R J; Kuntz I D; Wang C C
Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan.
Biochemistry 1998;37(16):5344-8.
1998: Buchbinder J L; Stephenson R C; Dresser M J; Pitera J W; Scanlan T S; Fletterick R J
Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family.
Biochemistry 1998;37(15):5096-106.
1998: Zhang Y H; Guo W; Wagner R L; Huang B L; McCabe L; Vilain E; Burris T P; Anyane-Yeboa K; Burghes A H; Chitayat D; Chudley A E; Genel M; Gertner J M; Klingensmith G J; Levine S N; Nakamoto J; New M I; Pagon R A; Pappas J G; Quigley C A; Rosenthal I M; Baxter J D; Fletterick R J; McCabe E R
DAX1 mutations map to putative structural domains in a deduced three-dimensional model.
American journal of human genetics 1998;62(4):855-64.
1998: Ribeiro R C; Apriletti J W; Wagner R L; West B L; Feng W; Huber R; Kushner P J; Nilsson S; Scanlan T; Fletterick R J; Schaufele F; Baxter J D
Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.
Recent progress in hormone research 1998;53():351-92; discussion 392-4.
1997: Gillmor S A; Villaseñor A; Fletterick R; Sigal E; Browner M F
The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity.
Nature structural biology 1997;4(12):1003-9.
1997: Lin K; Hwang P K; Fletterick R J
Distinct phosphorylation signals converge at the catalytic center in glycogen phosphorylases.
Structure (London, England : 1993) 1997;5(11):1511-23.
1997: Whitby F G; Luecke H; Kuhn P; Somoza J R; Huete-Perez J A; Phillips J D; Hill C P; Fletterick R J; Wang C C
Crystal structure of Tritrichomonas foetus inosine-5'-monophosphate dehydrogenase and the enzyme-product complex.
Biochemistry 1997;36(35):10666-74.
1997: Gillmor S A; Craik C S; Fletterick R J
Structural determinants of specificity in the cysteine protease cruzain.
Protein science : a publication of the Protein Society 1997;6(8):1603-11.
1997: Sosa H; Dias D P; Hoenger A; Whittaker M; Wilson-Kubalek E; Sablin E; Fletterick R J; Vale R D; Milligan R A
A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis.
Cell 1997;90(2):217-24.
1997: Buchbinder J L; Luong C B; Browner M F; Fletterick R J
Partial activation of muscle phosphorylase by replacement of serine 14 with acidic residues at the site of regulatory phosphorylation.
Biochemistry 1997;36(26):8039-44.
1997: Tsu C A; Perona J J; Fletterick R J; Craik C S
Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1.
Biochemistry 1997;36(18):5393-401.
1997: Perona J J; Tsu C A; Craik C S; Fletterick R J
Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix.
Biochemistry 1997;36(18):5381-92.
1997: Craig S P; Focia P J; Fletterick R J
Substitution of lysine for arginine at position 199 of a hypoxanthine phosphoribosyltransferase interferes with binding of the primary substrate to the active site.
Biochimica et biophysica acta 1997;1339(1):1-3.
1997: Collingwood T N; Rajanayagam O; Adams M; Wagner R; Cavaillès V; Kalkhoven E; Matthews C; Nystrom E; Stenlof K; Lindstedt G; Tisell L; Fletterick R J; Parker M G; Chatterjee V K
A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):248-53.
1997: Vale R D; Fletterick R J
The design plan of kinesin motors.
Annual review of cell and developmental biology 1997;13():745-77.
1996: Li R; Chen X; Gong B; Selzer P M; Li Z; Davidson E; Kurzban G; Miller R E; Nuzum E O; McKerrow J H; Fletterick R J; Gillmor S A; Craik C S; Kuntz I D; Cohen F E; Kenyon G L
Structure-based design of parasitic protease inhibitors.
Bioorganic & medicinal chemistry 1996;4(9):1421-7.
1996: Buchbinder J L; Fletterick R J
Role of the active site gate of glycogen phosphorylase in allosteric inhibition and substrate binding.
The Journal of biological chemistry 1996;271(37):22305-9.
1996: Lin K; Rath V L; Dai S C; Fletterick R J; Hwang P K
A protein phosphorylation switch at the conserved allosteric site in GP.
Science (New York, N.Y.) 1996;273(5281):1539-42.
1996: Somoza J R; Chin M S; Focia P J; Wang C C; Fletterick R J
Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus.
Biochemistry 1996;35(22):7032-40.
1996: Brinen L S; Willett W S; Craik C S; Fletterick R J
X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry 1996;35(19):5999-6009.
1996: Willett W S; Brinen L S; Fletterick R J; Craik C S
Delocalizing trypsin specificity with metal activation.
Biochemistry 1996;35(19):5992-8.
1996: Rath V L; Lin K; Hwang P K; Fletterick R J
The evolution of an allosteric site in phosphorylase.
Structure (London, England : 1993) 1996;4(4):463-73.
1996: Mehlhorn I; Groth D; Stöckel J; Moffat B; Reilly D; Yansura D; Willett W S; Baldwin M; Fletterick R; Cohen F E; Vandlen R; Henner D; Prusiner S B
High-level expression and characterization of a purified 142-residue polypeptide of the prion protein.
Biochemistry 1996;35(17):5528-37.
1996: Sablin E P; Kull F J; Cooke R; Vale R D; Fletterick R J
Crystal structure of the motor domain of the kinesin-related motor ncd.
Nature 1996;380(6574):555-9.
1996: Kull F J; Sablin E P; Lau R; Fletterick R J; Vale R D
Crystal structure of the kinesin motor domain reveals a structural similarity to myosin.
Nature 1996;380(6574):550-5.
1995: Wagner R L; Apriletti J W; McGrath M E; West B L; Baxter J D; Fletterick R J
A structural role for hormone in the thyroid hormone receptor.
Nature 1995;378(6558):690-7.
1995: Lin K; Hwang P K; Fletterick R J
Mechanism of regulation in yeast glycogen phosphorylase.
The Journal of biological chemistry 1995;270(45):26833-9.
1995: Shimizu T; Sablin E; Vale R D; Fletterick R; Pechatnikova E; Taylor E W
Expression, purification, ATPase properties, and microtubule-binding properties of the ncd motor domain.
Biochemistry 1995;34(40):13259-66.
1995: Nguyen J T; Inouye H; Baldwin M A; Fletterick R J; Cohen F E; Prusiner S B; Kirschner D A
X-ray diffraction of scrapie prion rods and PrP peptides.
Journal of molecular biology 1995;252(4):412-22.
1995: Fletterick R J; Bazan J F
When one and one are not two.
Nature structural biology 1995;2(9):721-3.
1995: Hoenger A; Sablin E P; Vale R D; Fletterick R J; Milligan R A
Three-dimensional structure of a tubulin-motor-protein complex.
Nature 1995;376(6537):271-4.
1995: Crerar M M; Karlsson O; Fletterick R J; Hwang P K
Chimeric muscle and brain glycogen phosphorylases define protein domains governing isozyme-specific responses to allosteric activation.
The Journal of biological chemistry 1995;270(23):13748-56.
1995: Ribeiro R C; Apriletti J W; West B L; Wagner R L; Fletterick R J; Schaufele F; Baxter J D
The molecular biology of thyroid hormone action.
Annals of the New York Academy of Sciences 1995;758():366-89.
1995: Buchbinder J L; Guinovart J J; Fletterick R J
Mutations in paired alpha-helices at the subunit interface of glycogen phosphorylase alter homotropic and heterotropic cooperativity.
Biochemistry 1995;34(19):6423-32.
1995: Buchbinder J L; Witkowski A; Smith S; Fletterick R J
Crystallization and preliminary diffraction studies of thioesterase II from rat mammary gland.
Proteins 1995;22(1):73-5.
1995: McGrath M E; Eakin A E; Engel J C; McKerrow J H; Craik C S; Fletterick R J
The crystal structure of cruzain: a therapeutic target for Chagas' disease.
Journal of molecular biology 1995;247(2):251-9.
1995: Guo J; Huang W; Zhou G W; Fletterick R J; Scanlan T S
Mechanistically different catalytic antibodies obtained from immunization with a single transition-state analog.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1694-8.
1995: Willett W S; Gillmor S A; Perona J J; Fletterick R J; Craik C S
Engineered metal regulation of trypsin specificity.
Biochemistry 1995;34(7):2172-80.
1995: Perona J J; Hedstrom L; Rutter W J; Fletterick R J
Structural origins of substrate discrimination in trypsin and chymotrypsin.
Biochemistry 1995;34(5):1489-99.
1995: McGrath M E; Gillmor S A; Fletterick R J
Ecotin: lessons on survival in a protease-filled world.
Protein science : a publication of the Protein Society 1995;4(2):141-8.
1995: Sablin E P; Fletterick R J
Crystallization and preliminary structural studies of the ncd motor domain.
Proteins 1995;21(1):68-9.
1994: Rath V L; Fletterick R J
Parallel evolution in two homologues of phosphorylase.
Nature structural biology 1994;1(10):681-90.
1994: Zhou G W; Guo J; Huang W; Fletterick R J; Scanlan T S
Crystal structure of a catalytic antibody with a serine protease active site.
Science (New York, N.Y.) 1994;265(5175):1059-64.
1994: Guenot J; Fletterick R J; Kollman P A
A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA.
Protein science : a publication of the Protein Society 1994;3(8):1276-85.
1994: Huang Z; Gabriel J M; Baldwin M A; Fletterick R J; Prusiner S B; Cohen F E
Proposed three-dimensional structure for the cellular prion protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7139-43.
1994: Browner M F; Hackos D; Fletterick R
Identification of the molecular trigger for allosteric activation in glycogen phosphorylase.
Nature structural biology 1994;1(5):327-33.
1994: McGrath M E; Erpel T; Bystroff C; Fletterick R J
Macromolecular chelation as an improved mechanism of protease inhibition: structure of the ecotin-trypsin complex.
The EMBO journal 1994;13(7):1502-7.
1994: Cohen F E; Pan K M; Huang Z; Baldwin M; Fletterick R J; Prusiner S B
Structural clues to prion replication.
Science (New York, N.Y.) 1994;264(5158):530-1.
1994: Fletterick R J; McGrath M E
Deconvoluting serpins.
Nature structural biology 1994;1(4):201-3.
1994: Perona J J; Hedstrom L; Wagner R L; Rutter W J; Craik C S; Fletterick R J
Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser.
Biochemistry 1994;33(11):3252-9.
1994: McGrath M E; Wagner R L; Apriletti J W; West B L; Ramalingam V; Baxter J D; Fletterick R J
Preliminary crystallographic studies of the ligand-binding domain of the thyroid hormone receptor complexed with triiodothyronine.
Journal of molecular biology 1994;237(2):236-9.
1994: Baldwin M A; Pan K M; Nguyen J; Huang Z; Groth D; Serban A; Gasset M; Mehlhorn I; Fletterick R J; Cohen F E
Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;343(1306):435-41.
1993: Pan K M; Baldwin M; Nguyen J; Gasset M; Serban A; Groth D; Mehlhorn I; Huang Z; Fletterick R J; Cohen F E
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):10962-6.
1993: Bystroff C; Baker D; Fletterick R J; Agard D A
PRISM: application to the solution of two protein structures.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 5):440-8.
1993: Baker D; Bystroff C; Fletterick R J; Agard D A
PRISM: topologically constrained phased refinement for macromolecular crystallography.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 5):429-39.
1993: Perona J J; Craik C S; Fletterick R J
Locating the catalytic water molecule in serine proteases.
Science (New York, N.Y.) 1993;261(5121):620-2.
1993: Perona J J; Tsu C A; McGrath M E; Craik C S; Fletterick R J
Relocating a negative charge in the binding pocket of trypsin.
Journal of molecular biology 1993;230(3):934-49.
1993: Perona J J; Tsu C A; Craik C S; Fletterick R J
Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI.
Journal of molecular biology 1993;230(3):919-33.
1993: Eakin A E; McGrath M E; McKerrow J H; Fletterick R J; Craik C S
Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi.
The Journal of biological chemistry 1993;268(9):6115-8.
1993: McGrath M E; Haymore B L; Summers N L; Craik C S; Fletterick R J
Structure of an engineered, metal-actuated switch in trypsin.
Biochemistry 1993;32(8):1914-9.
1993: Gasset M; Baldwin M A; Fletterick R J; Prusiner S B
Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):1-5.
1992: Luong C B; Browner M F; Fletterick R J; Haymore B L
Purification of glycogen phosphorylase isozymes by metal-affinity chromatography.
Journal of chromatography 1992;584(1):77-84.
1992: Goddette D W; Paech C; Yang S S; Mielenz J R; Bystroff C; Wilke M E; Fletterick R J
The crystal structure of the Bacillus lentus alkaline protease, subtilisin BL, at 1.4 A resolution.
Journal of molecular biology 1992;228(2):580-95.
1992: Browner M F; Fauman E B; Fletterick R J
Tracking conformational states in allosteric transitions of phosphorylase.
Biochemistry 1992;31(46):11297-304.
1992: Browner M F; Hwang P K; Fletterick R J
Cooperative binding is not required for activation of muscle phosphorylase.
Biochemistry 1992;31(46):11291-6.
1992: Gasset M; Baldwin M A; Lloyd D H; Gabriel J M; Holtzman D M; Cohen F; Fletterick R; Prusiner S B
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10940-4.
1992: Rath V L; Hwang P K; Fletterick R J
Purification and crystallization of glycogen phosphorylase from Saccharomyces cerevisiae.
Journal of molecular biology 1992;225(4):1027-34.
1992: McGrath M E; Vásquez J R; Craik C S; Yang A S; Honig B; Fletterick R J
Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
Biochemistry 1992;31(12):3059-64.
1992: Erpel T; Hwang P; Craik C S; Fletterick R J; McGrath M E
Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin.
Journal of bacteriology 1992;174(5):1704.
1992: Higaki J N; Fletterick R J; Craik C S
Engineered metalloregulation in enzymes.
Trends in biochemical sciences 1992;17(3):100-4.
1992: Browner M F; Fletterick R J
Phosphorylase: a biological transducer.
Trends in biochemical sciences 1992;17(2):66-71.
1991: Sprang S R; Withers S G; Goldsmith E J; Fletterick R J; Madsen N B
Structural basis for the activation of glycogen phosphorylase b by adenosine monophosphate.
Science (New York, N.Y.) 1991;254(5036):1367-71.
1991: McGrath M E; Erpel T; Browner M F; Fletterick R J
Expression of the protease inhibitor ecotin and its co-crystallization with trypsin.
Journal of molecular biology 1991;222(2):139-42.
1991: Coats W S; Browner M F; Fletterick R J; Newgard C B
An engineered liver glycogen phosphorylase with AMP allosteric activation.
The Journal of biological chemistry 1991;266(24):16113-9.
1991: Wilke M E; Higaki J N; Craik C S; Fletterick R J
Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis.
Journal of molecular biology 1991;219(3):525-32.
1991: Wilke M E; Higaki J N; Craik C S; Fletterick R J
Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases.
Journal of molecular biology 1991;219(3):511-23.
1991: McGrath M E; Hines W M; Sakanari J A; Fletterick R J; Craik C S
The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli.
The Journal of biological chemistry 1991;266(10):6620-5.
1991: Browner M F; Rasor P; Tugendreich S; Fletterick R J
Temperature-sensitive production of rabbit muscle glycogen phosphorylase in Escherichia coli.
Protein engineering 1991;4(3):351-7.
1991: Gregoret L M; Rader S D; Fletterick R J; Cohen F E
Hydrogen bonds involving sulfur atoms in proteins.
Proteins 1991;9(2):99-107.
1990: Sloane D L; Browner M F; Dauter Z; Wilson K; Fletterick R J; Sigal E
Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes.
Biochemical and biophysical research communications 1990;173(2):507-13.
1990: Phillips M A; Fletterick R; Rutter W J
Arginine 127 stabilizes the transition state in carboxypeptidase.
The Journal of biological chemistry 1990;265(33):20692-8.
1990: Chambers T J; Weir R C; Grakoui A; McCourt D W; Bazan J F; Fletterick R J; Rice C M
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8898-902.
1990: Lebo R V; Anderson L A; DiMauro S; Lynch E; Hwang P; Fletterick R
Rare McArdle disease locus polymorphic site on 11q13 contains CpG sequence.
Human genetics 1990;86(1):17-24.
1990: Higaki J N; Haymore B L; Chen S; Fletterick R J; Craik C S
Regulation of serine protease activity by an engineered metal switch.
Biochemistry 1990;29(37):8582-6.
1989: Soman K; Yang A S; Honig B; Fletterick R
Electrical potentials in trypsin isozymes.
Biochemistry 1989;28(26):9918-26.
1989: Bazan J F; Fletterick R J; Pilkis S J
Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):9642-6.
1989: McGrath M E; Wilke M E; Higaki J N; Craik C S; Fletterick R J
Crystal structures of two engineered thiol trypsins.
Biochemistry 1989;28(24):9264-70.
1989: Zhang W M; Browner M F; Fletterick R J; DePaoli-Roach A A; Roach P J
Primary structure of rabbit skeletal muscle glycogen synthase deduced from cDNA clones.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(13):2532-6.
1989: Dougherty W G; Parks T D; Cary S M; Bazan J F; Fletterick R J
Characterization of the catalytic residues of the tobacco etch virus 49-kDa proteinase.
Virology 1989;172(1):302-10.
1989: Goldsmith E J; Sprang S R; Hamlin R; Xuong N H; Fletterick R J
Domain separation in the activation of glycogen phosphorylase a.
Science (New York, N.Y.) 1989;245(4917):528-32.
1989: Bazan J F; Fletterick R J
Detection of a trypsin-like serine protease domain in flaviviruses and pestiviruses.
Virology 1989;171(2):637-9.
1989: Bazan J F; Fletterick R J
Comparative analysis of viral cysteine protease structural models.
FEBS letters 1989;249(1):5-7.
1989: Hwang P K; Tugendreich S; Fletterick R J
Molecular analysis of GPH1, the gene encoding glycogen phosphorylase in Saccharomyces cerevisiae.
Molecular and cellular biology 1989;9(4):1659-66.
1989: McGrath M E; Fletterick R J; Craik C S
Rapid preparation of proteins for crystallization trials.
BioTechniques 1989;7(3):246-7.
1989: Browner M F; Nakano K; Bang A G; Fletterick R J
Human muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distribution.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(5):1443-7.
1989: Newgard C B; Hwang P K; Fletterick R J
The family of glycogen phosphorylases: structure and function.
Critical reviews in biochemistry and molecular biology 1989;24(1):69-99.
1988: Servidei S; Shanske S; Zeviani M; Lebo R; Fletterick R; DiMauro S
McArdle's disease: biochemical and molecular genetic studies.
Annals of neurology 1988;24(6):774-81.
1988: Sprang S R; Acharya K R; Goldsmith E J; Stuart D I; Varvill K; Fletterick R J; Madsen N B; Johnson L N
Structural changes in glycogen phosphorylase induced by phosphorylation.
Nature 1988;336(6196):215-21.
1988: Bazan J F; Fletterick R J
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):7872-6.
1988: Newgard C B; Littman D R; van Genderen C; Smith M; Fletterick R J
Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes.
The Journal of biological chemistry 1988;263(8):3850-7.
1988: Sprang S R; Fletterick R J; Gráf L; Rutter W J; Craik C S
Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants.
Critical reviews in biotechnology 1988;8(3):225-36.
1987: Braun M J; Gonda M A; George D G; Bazan J F; Fletterick R J; Prusiner S B
The burden of proof in linking AIDS to scrapie.
Nature 1987;330(6148):525-6.
1987: Pastuszyn A; Noland B J; Bazan J F; Fletterick R J; Scallen T J
Primary sequence and structural analysis of sterol carrier protein 2 from rat liver: homology with immunoglobulins.
The Journal of biological chemistry 1987;262(27):13219-27.
1987: Sprang S; Goldsmith E; Fletterick R
Structure of the nucleotide activation switch in glycogen phosphorylase a.
Science (New York, N.Y.) 1987;237(4818):1012-9.
1987: Sprang S; Standing T; Fletterick R J; Stroud R M; Finer-Moore J; Xuong N H; Hamlin R; Rutter W J; Craik C S
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
Science (New York, N.Y.) 1987;237(4817):905-9.
1987: Graf L; Craik C S; Patthy A; Roczniak S; Fletterick R J; Rutter W J
Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin.
Biochemistry 1987;26(9):2616-23.
1987: Newgard C B; Fletterick R J; Anderson L A; Lebo R V
The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14.
American journal of human genetics 1987;40(4):351-64.
1987: Craik C S; Roczniak S; Sprang S; Fletterick R; Rutter W
Redesigning trypsin via genetic engineering.
Journal of cellular biochemistry 1987;33(3):199-211.
1987: Goldsmith E J; Fletterick R J; Withers S G
The three-dimensional structure of acarbose bound to glycogen phosphorylase.
The Journal of biological chemistry 1987;262(4):1449-55.
1987: Fernando Bazan J; Fletterick R J; Prusiner S B
AIDS virus and scrapie protein genes.
Nature 1987;325(6105):581.
1987: Bazan J F; Fletterick R J; McKinley M P; Prusiner S B
Predicted secondary structure and membrane topology of the scrapie prion protein.
Protein engineering 1987;1(2):125-35.
1987: Rath V L; Newgard C B; Sprang S R; Goldsmith E J; Fletterick R J
Modeling the biochemical differences between rabbit muscle and human liver phosphorylase.
Proteins 1987;2(3):225-35.
1987: Burke J; Hwang P; Anderson L; Lebo R; Gorin F; Fletterick R
Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase.
Proteins 1987;2(3):177-87.
1986: Hwang P K; Fletterick R J
Convergent and divergent evolution of regulatory sites in eukaryotic phosphorylases.
Nature 1986;324(6092):80-4.
1986: Newgard C B; Nakano K; Hwang P K; Fletterick R J
Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(21):8132-6.
1986: Nakano K; Hwang P K; Fletterick R J
Complete cDNA sequence for rabbit muscle glycogen phosphorylase.
FEBS letters 1986;204(2):283-7.
1986: Cohen F E; Abarbanel R M; Kuntz I D; Fletterick R J
Turn prediction in proteins using a pattern-matching approach.
Biochemistry 1986;25(1):266-75.
1986: Fletterick R J; Burke J A; Hwang P K; Nakano K; Newgard C B
Structural relationships in glycogen phosphorylases.
Annals of the New York Academy of Sciences 1986;478():220-32.
1985: Hwang P K; See Y P; Vincentini A M; Powers M A; Fletterick R J; Crerar M M
Comparative sequence analysis of rat, rabbit, and human muscle glycogen phosphorylase cDNAs.
European journal of biochemistry / FEBS 1985;152(2):267-74.
1985: Craik C S; Largman C; Fletcher T; Roczniak S; Barr P J; Fletterick R; Rutter W J
Redesigning trypsin: alteration of substrate specificity.
Science (New York, N.Y.) 1985;228(4697):291-7.
1985: Fletterick R J; Sygusch J
Measuring X-ray diffraction data from large proteins with X-ray diffractometry.
Methods in enzymology 1985;114():386-97.
1984: Hwang P; Stern M; Fletterick R J
Purification and crystallization of bovine liver phosphorylase.
Biochimica et biophysica acta 1984;791(2):252-8.
1984: Lebo R V; Gorin F; Fletterick R J; Kao F T; Cheung M C; Bruce B D; Kan Y W
High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11.
Science (New York, N.Y.) 1984;225(4657):57-9.
1984: Thaller C; Alberts B; Goldsmith E; Sprang S; Fletterick R
Crystallization of the gene 45 protein from the DNA replication fork of bacteriophage T4.
The Journal of biological chemistry 1984;259(4):2568-9.
1983: Cohen F E; Abarbanel R M; Kuntz I D; Fletterick R J
Secondary structure assignment for alpha/beta proteins by a combinatorial approach.
Biochemistry 1983;22(21):4894-904.
1983: Madsen N B; Shechosky S; Fletterick R J
Site-site interactions in glycogen phosphorylase b probed by ligands specific for each site.
Biochemistry 1983;22(19):4460-5.
1983: Craik C S; Rutter W J; Fletterick R
Splice junctions: association with variation in protein structure.
Science (New York, N.Y.) 1983;220(4602):1125-9.
1982: Withers S G; Madsen N B; Sprang S R; Fletterick R J
Catalytic site of glycogen phosphorylase: structural changes during activation and mechanistic implications.
Biochemistry 1982;21(21):5372-82.
1982: Sprang S R; Goldsmith E J; Fletterick R J; Withers S G; Madsen N B
Catalytic site of glycogen phosphorylase: structure of the T state and specificity for alpha-D-glucose.
Biochemistry 1982;21(21):5364-71.
1982: Craik C S; Sprang S; Fletterick R; Rutter W J
Intron-exon splice junctions map at protein surfaces.
Nature 1982;299(5879):180-2.
1982: Sprang S; Fletterick R; Stern M; Yang D; Madsen N; Sturtevant J
Analysis of an allosteric binding site: the nucleoside inhibitor site of phosphorylase alpha.
Biochemistry 1982;21(9):2036-48.
1982: Goldsmith E; Sprang S; Fletterick R
Structure of maltoheptaose by difference Fourier methods and a model for glycogen.
Journal of molecular biology 1982;156(2):411-27.
1981: Kasvinsky P J; Fletterick R J; Madsen N B
Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes.
Canadian journal of biochemistry 1981;59(6):387-95.
1980: Sprang S; Fletterick R J
Subunit interactions and the allosteric response in phosphorylase.
Biophysical journal 1980;32(1):175-92.
1980: Matela R J; Fletterick R J
Computer simulation of cellular self-sorting: a topological exchange model.
Journal of theoretical biology 1980;84(4):673-90.
1980: Fletterick R J; Madsen N B
The structures and related functions of phosphorylase a.
Annual review of biochemistry 1980;49():31-61.

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