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Gert Jan Fleuren

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Mariëtte I E Van Poelgeest; Marij J P Welters; Edith M G van Esch; EL van Persijn van Meerten; Dorien M A Berends-van der Meer; Lorraine M Fathers; Gert Jan Fleuren; Gemma G Kenter; Gijs Kerpershoek; Margriet J G Löwik; Cornelis J M Melief; Jaap Oostendorp; Linda F M Stynenbosch; Rob Valentijn; Muriel van den Hende; Sjoerd H van der burg
HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial.
Peggy J de Vos van Steenwijk; Lorraine M Fathers; Gert Jan Fleuren; Bart W J Hellebrekers; Gemma G Kenter; Margriet J G Löwik; Cornelis J M Melief; Jaap Oostendorp; Tamara H Ramwadhdoebe; Rob Valentijn; Caroline E van der Minne; Mariëtte I E Van Poelgeest; Marij J P Welters; Dorien M A Berends-van der Meer; Sjoerd H van der burg
A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions.
J N I Vet; F M Aziz; S Budiningsih; Santoso Cornain; Gert Jan Fleuren; F C Henderson; J L Kooijman; G Purwoto; I G D Surya; H Susanto; J B Trimbos; A A W Peters
Single-visit approach of cervical cancer screening: see and treat in Indonesia.

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All Publications

2013: Mariëtte I E Van Poelgeest; Marij J P Welters; Edith M G van Esch; EL van Persijn van Meerten; Dorien M A Berends-van der Meer; Lorraine M Fathers; Gert Jan Fleuren; Gemma G Kenter; Gijs Kerpershoek; Margriet J G Löwik; Cornelis J M Melief; Jaap Oostendorp; Linda F M Stynenbosch; Rob Valentijn; Muriel van den Hende; Sjoerd H van der burg
HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial.
Journal of translational medicine 2013;11():88.
2012: Peggy J de Vos van Steenwijk; Lorraine M Fathers; Gert Jan Fleuren; Bart W J Hellebrekers; Gemma G Kenter; Margriet J G Löwik; Cornelis J M Melief; Jaap Oostendorp; Tamara H Ramwadhdoebe; Rob Valentijn; Caroline E van der Minne; Mariëtte I E Van Poelgeest; Marij J P Welters; Dorien M A Berends-van der Meer; Sjoerd H van der burg
A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions.
Cancer immunology, immunotherapy : CII 2012;61(9):1485-92.
2012: J N I Vet; F M Aziz; S Budiningsih; Santoso Cornain; Gert Jan Fleuren; F C Henderson; J L Kooijman; G Purwoto; I G D Surya; H Susanto; J B Trimbos; A A W Peters
Single-visit approach of cervical cancer screening: see and treat in Indonesia.
British journal of cancer 2012;107(5):772-7.
2012: M Schrevel; Natalja T Ter Haar; J B M Z Trimbos; Sjoerd H van der burg; Gert Jan Fleuren; Arko Gorter; R Karim; Ekaterina S. Jordanova
CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients.
British journal of cancer 2012;106(9):1520-5.
2012: Vivian M Spaans; A A W Peters; Gert Jan Fleuren; Ekaterina S. Jordanova
HLA-E expression in cervical adenocarcinomas: association with improved long-term survival.
Journal of translational medicine 2012;10():184.
2012: Lisnawati Rachmadi; Budiningsih Siregar; Ingrid van der Linden-Narain; Santoso Cornain; Gert Jan Fleuren; Ekaterina S. Jordanova; Sandra Kolkman-Uljee; Gatot Purwoto; Maud Veselic
Cytomorphological analysis of uterine cervical pap smears in relation to human papillomavirus infection in Indonesian women.
Acta cytologica 2012;56(2):171-6.
2012: Yayan T Sundara; Supriadi Gandamihardja; Bethy S Hernowo; Ekaterina S. Jordanova; Gert Jan Fleuren
Decidual infiltration of FoxP3⁺ regulatory T cells, CD3⁺ T cells, CD56⁺ decidual natural killer cells and Ki-67 trophoblast cells in hydatidiform mole compared to normal and ectopic pregnancies.
Molecular medicine reports 2012;5(1):275-81.
2011: Willem E Corver; Gert Jan Fleuren; Natalja T Ter Haar; Jan Oosting
Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations.
Cellular oncology (Dordrecht) 2011;34(6):553-63.
2011: Marlies Schrevel; Arko Gorter; Sandra M Kolkman-Uljee; J Baptist Trimbos; Gert Jan Fleuren; Ekaterina S. Jordanova
Molecular mechanisms of epidermal growth factor receptor overexpression in patients with cervical cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011;24(5):720-8.
2010: Marij J P Welters; Gemma G Kenter; Peggy J de Vos van Steenwijk; Margriet J G Löwik; Dorien M A Berends-van der Meer; Farah Essahsah; Linda F M Stynenbosch; Annelies P G Vloon; Tamara H Ramwadhdoebe; Sytse J Piersma; Jeanette M van der Hulst; Rob Valentijn; Lorraine M Fathers; Jan Wouter Drijfhout; Kees L M C Franken; Jaap Oostendorp; Gert Jan Fleuren; Cornelis J M Melief; Sjoerd H van der burg
Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(26):11895-9.
2009: Gemma G Kenter; Marij J P Welters; Rob Valentijn; Margriet J G Lowik; Dorien M A Berends-van der Meer; Annelies P G Vloon; Farah Essahsah; Lorraine M Fathers; Rienk Offringa; Jan Wouter Drijfhout; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Sjoerd H van der burg; Cornelis J M Melief
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.
The New England journal of medicine 2009;361(19):1838-47.
2008: Peggy J de Vos van Steenwijk; Sytse J Piersma; Marij J P Welters; Jeanette M van der Hulst; Gert Jan Fleuren; Bart W J Hellebrekers; Gemma G Kenter; Sjoerd H van der burg
Surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional HPV16-specific T-cell response.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(22):7188-95.
2008: Jan Willem F Dierssen; Marjo Van Puijenbroek; David A Dezentjé; Gert Jan Fleuren; Cees J Cornelisse; Tom van Wezel; Rienk Offringa; Hans Morreau
Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours.
European journal of human genetics : EJHG 2008;16(10):1235-9.
2008: J N I Vet; Marjon A de Boer; B E W M van den Akker; Budiningsih Siregar; S Budiningsih; D Tyasmorowati; Santoso Cornain; A A W Peters; Gert Jan Fleuren
Prevalence of human papillomavirus in Indonesia: a population-based study in three regions.
British journal of cancer 2008;99(1):214-8.
2008: Judith N Kloth; Gemma G Kenter; H Siebe Spijker; Sandra Uljee; Willem E Corver; Ekaterina S. Jordanova; Gert Jan Fleuren; Arko Gorter
Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008;21(7):866-75.
2008: Muriel van den Hende; Mariëtte I E Van Poelgeest; Jeanette M van der Hulst; J de Jong; Jan Wouter Drijfhout; Gert Jan Fleuren; Rob Valentijn; Amon R Wafelman; Gijs M Slappendel; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg; Gemma G Kenter
Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia.
International journal of cancer. Journal international du cancer 2008;123(1):146-52.
2008: Ekaterina S. Jordanova; Arko Gorter; Ouissam Ayachi; Frans A Prins; Lindy G Durrant; Gemma G Kenter; Sjoerd H van der burg; Gert Jan Fleuren
Human leukocyte antigen class I, MHC class I chain-related molecule A, and CD8+/regulatory T-cell ratio: which variable determines survival of cervical cancer patients?
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(7):2028-35.
2008: Sytse J Piersma; Marij J P Welters; Jeanette M van der Hulst; Judith N Kloth; Kitty M C Kwappenberg; Baptist J Trimbos; Cornelis J M Melief; Bart W J Hellebrekers; Gert Jan Fleuren; Gemma G Kenter; Rienk Offringa; Sjoerd H van der burg
Human papilloma virus specific T cells infiltrating cervical cancer and draining lymph nodes show remarkably frequent use of HLA-DQ and -DP as a restriction element.
International journal of cancer. Journal international du cancer 2008;122(3):486-94.
2008: Marij J P Welters; Gemma G Kenter; Sytse J Piersma; Annelies P G Vloon; Margriet J G Löwik; Dorien M A Berends-van der Meer; Jan Wouter Drijfhout; Rob Valentijn; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Rienk Offringa; Cornelis J M Melief; Sjoerd H van der burg
Induction of tumor-specific CD4+ and CD8+ T-cell immunity in cervical cancer patients by a human papillomavirus type 16 E6 and E7 long peptides vaccine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):178-87.
2008: Gemma G Kenter; Marij J P Welters; Rob Valentijn; Margriet J G Lowik; Dorien M A Berends-van der Meer; Annelies P G Vloon; Jan Wouter Drijfhout; Amon R Wafelman; Jaap Oostendorp; Gert Jan Fleuren; Rienk Offringa; Sjoerd H van der burg; Cornelis J M Melief
Phase I immunotherapeutic trial with long peptides spanning the E6 and E7 sequences of high-risk human papillomavirus 16 in end-stage cervical cancer patients shows low toxicity and robust immunogenicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):169-77.
2008: Judith N Kloth; Arko Gorter; Natalja T Ter Haar; Willem E Corver; Ekaterina S. Jordanova; Gemma G Kenter; Gert Jan Fleuren
Lack of TNFalpha mRNA expression in cervical cancer is not associated with loss of heterozygosity at 6p21.3, inactivating mutations or promoter methylation.
Molecular immunology 2008;45(1):152-9.
2007: Marjon A de Boer; Ekaterina S. Jordanova; Mariëtte I E Van Poelgeest; Brendy E van den Akker; Sjoerd H van der burg; Gemma G Kenter; Gert Jan Fleuren
Circulating human papillomavirus type 16 specific T-cells are associated with HLA Class I expression on tumor cells, but not related to the amount of viral oncogene transcripts.
International journal of cancer. Journal international du cancer 2007;121(12):2711-5.
2007: Carola J Haven; Marjo Van Puijenbroek; M H Tan; Bin Tean Teh; Gert Jan Fleuren; Tom van Wezel; Hans Morreau
Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas.
Clinical endocrinology 2007;67(3):370-6.
2007: Sjoerd H van der burg; Sytse J Piersma; Annemieke de Jong; Jeanette M van der Hulst; Kitty M C Kwappenberg; Muriel van den Hende; Marij J P Welters; Jon van Rood; Gert Jan Fleuren; Cornelis J M Melief; Gemma G Kenter; Rienk Offringa
Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12087-92.
2007: Suzanne Hazelbag; Gemma G Kenter; Arko Gorter; Enno J Dreef; LA Koopman; Shelia M Violette; Paul H Weinreb; Gert Jan Fleuren
Overexpression of the alpha v beta 6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival.
The Journal of pathology 2007;212(3):316-24.
2007: Christine F W Vermeulen; Ekaterina S. Jordanova; Karoly Szuhai; Sandra M Kolkman-Uljee; M Albert Vrede; A A W Peters; Ed Schuuring; Gert Jan Fleuren
Physical status of multiple human papillomavirus genotypes in flow-sorted cervical cancer cells.
Cancer genetics and cytogenetics 2007;175(2):132-7.
2007: Christine F W Vermeulen; Ekaterina S. Jordanova; Natalja T Ter Haar; Sandra M Kolkman-Uljee; Noel F de Miranda; Soldano Ferrone; A A W Peters; Gert Jan Fleuren
Expression and genetic analysis of transporter associated with antigen processing in cervical carcinoma.
Gynecologic oncology 2007;105(3):593-9.
2007: Akash M Mehta; Ekaterina S. Jordanova; Tom van Wezel; Hae-Won Uh; Willem E Corver; Kitty M C Kwappenberg; Willem Verduijn; Gemma G Kenter; Sjoerd H van der burg; Gert Jan Fleuren
Genetic variation of antigen processing machinery components and association with cervical carcinoma.
Genes, chromosomes & cancer 2007;46(6):577-86.
2007: Christine F W Vermeulen; Mathilde E Boon; A Grünberg; I B S van der Linden-Narain; M Albert Vrede; Friedo W Dekker; A A W Peters; Gert Jan Fleuren
Decreased prevalence of dysplasia in high-risk population immigrants in a low-risk area for cervical cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2007;17(3):646-50.
2007: E S M Tiersma; A A W Peters; Marije van der Lee; Adriaan P Visser; Gert Jan Fleuren
Reasons for early interventions by gynaecologists in a clinical follow-up study on cervical intraepithelial neoplasia.
European journal of obstetrics, gynecology, and reproductive biology 2007;132(1):111-5.
2007: QD Pieterse; Gemma G Kenter; Katja N Gaarenstroom; A A W Peters; Stefan Willems; Gert Jan Fleuren; J Baptist Trimbos
The number of pelvic lymph nodes in the quality control and prognosis of radical hysterectomy for the treatment of cervical cancer.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2007;33(2):216-21.
2007: Henry J M A A Zijlmans; Gert Jan Fleuren; Hans J Baelde; Paul H C Eilers; Gemma G Kenter; Arko Gorter
Role of tumor-derived proinflammatory cytokines GM-CSF, TNF-alpha, and IL-12 in the migration and differentiation of antigen-presenting cells in cervical carcinoma.
Cancer 2007;109(3):556-65.
2007: Jan Willem F Dierssen; Noel F C C de Miranda; Soldano Ferrone; Marjo Van Puijenbroek; Cees J Cornelisse; Gert Jan Fleuren; Tom van Wezel; Hans Morreau
HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression.
BMC cancer 2007;7():33.
2007: Judith N Kloth; Jan Oosting; Tom van Wezel; Karoly Szuhai; Jeroen Knijnenburg; Arko Gorter; Gemma G Kenter; Gert Jan Fleuren; Ekaterina S. Jordanova
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer.
BMC genomics 2007;8():53.
2007: Sytse J Piersma; Ekaterina S. Jordanova; Mariëtte I E Van Poelgeest; Kitty M C Kwappenberg; Jeanette M van der Hulst; Jan Wouter Drijfhout; Cornelis J M Melief; Gemma G Kenter; Gert Jan Fleuren; Rienk Offringa; Sjoerd H van der burg
High number of intraepithelial CD8+ tumor-infiltrating lymphocytes is associated with the absence of lymph node metastases in patients with large early-stage cervical cancer.
Cancer research 2007;67(1):354-61.
2007: Marjon A de Boer; Ekaterina S. Jordanova; Gemma G Kenter; A A W Peters; Willem E Corver; J Baptist Trimbos; Gert Jan Fleuren
High human papillomavirus oncogene mRNA expression and not viral DNA load is associated with poor prognosis in cervical cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):132-8.
2006: Nathalie L G Sieben; Guido M J M Roemen; Jan Oosting; Gert Jan Fleuren; Manon van Engeland; J Prat
Clonal analysis favours a monoclonal origin for serous borderline tumours with peritoneal implants.
The Journal of pathology 2006;210(4):405-11.
2006: Christine F W Vermeulen; Antoon Grünberg; Lex A W Peters; Ingrid B S van der Linden-Narain; M Albert Vrede; Eveline J T Krul; Friedo W Dekker; Gert Jan Fleuren
Ethnic patterns of cytologic abnormalities in cervical smears in suriname, a high-risk area for cervical cancer.
Acta cytologica 2006;50(6):621-6.
2006: Marjon A de Boer; J N I Vet; Mohammed Farid Aziz; Santoso Cornain; G Purwoto; B E W M van den Akker; Anneke Dijkman; A A W Peters; Gert Jan Fleuren
Human papillomavirus type 18 and other risk factors for cervical cancer in Jakarta, Indonesia.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006;16(5):1809-14.
2006: Cornelis FM Sier; Kim Zuidwijk; Henry J M A A Zijlmans; roeland hanemaaijer; Adri A Mulder-Stapel; Frans A Prins; Enno J Dreef; Gemma G Kenter; Gert Jan Fleuren; Arko Gorter
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2006;118(12):2991-8.
2006: Henry J M A A Zijlmans; Gert Jan Fleuren; Hans J Baelde; Paul H C Eilers; Gemma G Kenter; Arko Gorter
The absence of CCL2 expression in cervical carcinoma is associated with increased survival and loss of heterozygosity at 17q11.2.
The Journal of pathology 2006;208(4):507-17.
2006: Marij J P Welters; Pauline van der Logt; Susan J F van den Eeden; Kitty M C Kwappenberg; Jan Wouter Drijfhout; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Sjoerd H van der burg; Rienk Offringa
Detection of human papillomavirus type 18 E6 and E7-specific CD4+ T-helper 1 immunity in relation to health versus disease.
International journal of cancer. Journal international du cancer 2006;118(4):950-6.
2006: Mariëtte I E Van Poelgeest; Esther R Nijhuis; Kitty M C Kwappenberg; Ineke E Hamming; Jan Wouter Drijfhout; Gert Jan Fleuren; Ate G J van der Zee; Cornelis J M Melief; Gemma G Kenter; Hans W Nijman; Rienk Offringa; Sjoerd H van der burg
Distinct regulation and impact of type 1 T-cell immunity against HPV16 L1, E2 and E6 antigens during HPV16-induced cervical infection and neoplasia.
International journal of cancer. Journal international du cancer 2006;118(3):675-83.
2005: Christine F W Vermeulen; Ekaterina S. Jordanova; Yvon A Zomerdijk-Nooijen; Natalja T Ter Haar; A A W Peters; Gert Jan Fleuren
Frequent HLA class I loss is an early event in cervical carcinogenesis.
Human immunology 2005;66(11):1167-73.
2005: Nathalie L G Sieben; Jan Oosting; Adrienne M Flanagan; Jaime Prat; Guido M J M Roemen; Sandra M Kolkman-Uljee; Ronald van Eijk; Cees J Cornelisse; Gert Jan Fleuren; Manon van Engeland
Differential gene expression in ovarian tumors reveals Dusp 4 and Serpina 5 as key regulators for benign behavior of serous borderline tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(29):7257-64.
2005: Judith N Kloth; Gert Jan Fleuren; Jan Oosting; Renée X de Menezes; Paul H C Eilers; Gemma G Kenter; Arko Gorter
Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines.
Carcinogenesis 2005;26(9):1493-502.
2005: E S M Tiersma; Marije van der Lee; Bert Garssen; A A W Peters; Adriaan P Visser; Gert Jan Fleuren; K M van Leeuwen; Saskia Le Cessie; Karl Goodkin
Psychosocial factors and the course of cervical intra-epithelial neoplasia: a prospective study.
Gynecologic oncology 2005;97(3):879-86.
2005: Willem E Corver; Natalja T Ter Haar; Enno J Dreef; Noel F C C Miranda; Frans A Prins; Ekaterina S. Jordanova; Cees J Cornelisse; Gert Jan Fleuren
High-resolution multi-parameter DNA flow cytometry enables detection of tumour and stromal cell subpopulations in paraffin-embedded tissues.
The Journal of pathology 2005;206(2):233-41.
2005: Marjon A de Boer; Lex A W Peters; Mohammed Farid Aziz; Budiningsih Siregar; Santoso Cornain; M Albert Vrede; Ekaterina S. Jordanova; Gert Jan Fleuren
Human papillomavirus type 18 variants: histopathology and E6/E7 polymorphisms in three countries.
International journal of cancer. Journal international du cancer 2005;114(3):422-5.
2004: Suzanne Hazelbag; Gemma G Kenter; Arko Gorter; Gert Jan Fleuren
Prognostic relevance of TGF-beta1 and PAI-1 in cervical cancer.
International journal of cancer. Journal international du cancer 2004;112(6):1020-8.
2004: Carola J Haven; Viive M Howell; Paul H C Eilers; Robert Dunne; Masayuki Takahashi; Marjo Van Puijenbroek; Kyle A Furge; Job Kievit; Min-Han Tan; Gert Jan Fleuren; Bruce G Robinson; Leigh W Delbridge; Jeanette Philips; Anne E Nelson; Ulf Krause; Henning Dralle; Cuong Hoang-Vu; Oliver Gimm; Hans Morreau; Deborah J Marsh; Bin Tean Teh
Gene expression of parathyroid tumors: molecular subclassification and identification of the potential malignant phenotype.
Cancer research 2004;64(20):7405-11.
2004: J Baptist Trimbos; A F Lambeek; A A W Peters; Ron Wolterbeek; Katja N Gaarenstroom; Gert Jan Fleuren; Gemma G Kenter
Prognostic difference of surgical treatment of exophytic versus barrel-shaped bulky cervical cancer.
Gynecologic oncology 2004;95(1):77-81.
2004: Matthew J Ferber; Paul H C Eilers; Ed Schuuring; James A L Fenton; Gert Jan Fleuren; Gemma G Kenter; Karoly Szuhai; David I Smith; Anton K Raap; Antoinette A T P Brink
Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13.
Cancer genetics and cytogenetics 2004;154(1):1-9.
2004: Marjon A de Boer; Lex A W Peters; Mohammed Farid Aziz; Budiningsih Siregar; Santoso Cornain; M Albert Vrede; Ekaterina S. Jordanova; Sandra M Kolkman-Uljee; Gert Jan Fleuren
Human papillomavirus type 16 E6, E7, and L1 variants in cervical cancer in Indonesia, Suriname, and The Netherlands.
Gynecologic oncology 2004;94(2):488-94.
2004: Annemieke de Jong; Mariëtte I E Van Poelgeest; Jeanette M van der Hulst; Jan Wouter Drijfhout; Gert Jan Fleuren; Cornelis J M Melief; Gemma G Kenter; Rienk Offringa; Sjoerd H van der burg
Human papillomavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6.
Cancer research 2004;64(15):5449-55.
2004: Kyra A Gelderman; Peter Kuppen; Noriko Okada; Gert Jan Fleuren; Arko Gorter
Tumor-specific inhibition of membrane-bound complement regulatory protein Crry with bispecific monoclonal antibodies prevents tumor outgrowth in a rat colorectal cancer lung metastases model.
Cancer research 2004;64(12):4366-72.
2004: Maaike C Schellekens; Anneke Dijkman; Mohammed Farid Aziz; Budiningsih Siregar; Santoso Cornain; Sandra M Kolkman-Uljee; Lex A W Peters; Gert Jan Fleuren
Prevalence of single and multiple HPV types in cervical carcinomas in Jakarta, Indonesia.
Gynecologic oncology 2004;93(1):49-53.
2004: Anand G Menon; Connie M Janssen-Van Rhijn; Hans Morreau; Hein Putter; R A E M Tollenaar; Cornelis J H van de Velde; Gert Jan Fleuren; Peter Kuppen
Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis.
Laboratory investigation; a journal of technical methods and pathology 2004;84(4):493-501.
2004: Anand G Menon; R A E M Tollenaar; Cornelis J H van de Velde; Hein Putter; Connie M Janssen-Van Rhijn; Rob Keijzer; Gert Jan Fleuren; Peter Kuppen
p53 and HLA class-I expression are not down-regulated in colorectal cancer liver metastases.
Clinical & experimental metastasis 2004;21(1):79-85.
2004: Bin Tean Teh; Viive M Howell; Carola J Haven; Katherine Kahnoski; Sok Kean Khoo; David Petillo; Jindong Chen; Gert Jan Fleuren; Bruce G Robinson; Leigh W Delbridge; Jeanette Philips; Anne E Nelson; Ulf Krause; K Hammje; Henning Dralle; Cuong Hoang-Vu; Oliver Gimm; Deborah J Marsh; Hans Morreau
Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.
Human genetics 2004;114(2):224.
2004: Bin Tean Teh; Viive M Howell; Carola J Haven; Katherine Kahnoski; Sok Kean Khoo; David Petillo; Jindong Chen; Gert Jan Fleuren; Bruce G Robinson; Leigh W Delbridge; Jeanette Philips; Anne E Nelson; Ulf Krause; K Hammje; Henning Dralle; Cuong Hoang-Vu; Oliver Gimm; Deborah J Marsh; Hans Morreau
Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.
Human genetics 2004;114(2):223.
2004: Bin Tean Teh; Viive M Howell; Carola J Haven; Katherine Kahnoski; Sok Kean Khoo; David Petillo; Jindong Chen; Gert Jan Fleuren; Bruce G Robinson; Leigh W Delbridge; Jeanette Philips; Anne E Nelson; Ulf Krause; K Hammje; Henning Dralle; Cuong Hoang-Vu; Oliver Gimm; Deborah J Marsh; Hans Morreau
Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.
Human genetics 2004;114(2):223.
2004: Bin Tean Teh; Viive M Howell; Carola J Haven; Katherine Kahnoski; Sok Kean Khoo; David Petillo; Jindong Chen; Gert Jan Fleuren; Bruce G Robinson; Leigh W Delbridge; Jeanette Philips; Anne E Nelson; Ulf Krause; K Hammje; Henning Dralle; Cuong Hoang-Vu; Oliver Gimm; Deborah J Marsh; Hans Morreau
Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.
Human genetics 2004;114(2):223.
2004: Bin Tean Teh; Viive M Howell; Carola J Haven; Katherine Kahnoski; Sok Kean Khoo; David Petillo; Jindong Chen; Gert Jan Fleuren; Bruce G Robinson; Leigh W Delbridge; Jeanette Philips; Anne E Nelson; Ulf Krause; K Hammje; Henning Dralle; Cuong Hoang-Vu; Oliver Gimm; Deborah J Marsh; Hans Morreau
Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.
Human genetics 2004;114(2):222.
2004: Bin Tean Teh; Viive M Howell; Carola J Haven; Katherine Kahnoski; Sok Kean Khoo; David Petillo; Jindong Chen; Gert Jan Fleuren; Bruce G Robinson; Leigh W Delbridge; Jeanette Philips; Anne E Nelson; Ulf Krause; K Hammje; Henning Dralle; Cuong Hoang-Vu; Oliver Gimm; Deborah J Marsh; Hans Morreau
Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.
Human genetics 2004;114(2):222.
2004: Bin Tean Teh; Viive M Howell; Carola J Haven; Katherine Kahnoski; Sok Kean Khoo; David Petillo; Jindong Chen; Gert Jan Fleuren; Bruce G Robinson; Leigh W Delbridge; Jeanette Philips; Anne E Nelson; Ulf Krause; K Hammje; Henning Dralle; Cuong Hoang-Vu; Oliver Gimm; Deborah J Marsh; Hans Morreau
Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.
Human genetics 2004;114(2):221.
2004: Carola J Haven; Marjo Van Puijenbroek; Marcel Karperien; Gert Jan Fleuren; Hans Morreau
Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma.
The Journal of pathology 2004;202(1):86-94.
2003: Viive M Howell; Carola J Haven; Katherine Kahnoski; Sok Kean Khoo; David Petillo; Jindong Chen; Gert Jan Fleuren; Bruce G Robinson; Leigh W Delbridge; Jeanette Philips; Anne E Nelson; Ulf Krause; K Hammje; Henning Dralle; Cuong Hoang-Vu; Oliver Gimm; Deborah J Marsh; Hans Morreau; Bin Tean Teh
HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours.
Journal of medical genetics 2003;40(9):657-63.
2003: E S M Tiersma; A A W Peters; H A Mooij; Gert Jan Fleuren
Visualising scanning patterns of pathologists in the grading of cervical intraepithelial neoplasia.
Journal of clinical pathology 2003;56(9):677-80.
2003: Nathalie L G Sieben; Sandra M Kolkman-Uljee; Adrienne M Flanagan; Saskia Le Cessie; Anne-Marie Cleton-Jansen; Cees J Cornelisse; Gert Jan Fleuren
Molecular genetic evidence for monoclonal origin of bilateral ovarian serous borderline tumors.
The American journal of pathology 2003;162(4):1095-101.
2003: Anand G Menon; Gert Jan Fleuren; Ellen A Alphenaar; Liesbeth E Jonges; Connie M Janssen-Van Rhijn; N Geeske Ensink; Hein Putter; R A E M Tollenaar; Cornelis J H van de Velde; Peter Kuppen
A basal membrane-like structure surrounding tumour nodules may prevent intraepithelial leucocyte infiltration in colorectal cancer.
Cancer immunology, immunotherapy : CII 2003;52(2):121-6.
2003: Marij J P Welters; Annemieke de Jong; Susan J F van den Eeden; Jeanette M van der Hulst; Kitty M C Kwappenberg; Sabrin Hassane; Kees L M C Franken; Jan Wouter Drijfhout; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Rienk Offringa; Sjoerd H van der burg
Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter.
Cancer research 2003;63(3):636-41.
2002: Suzanne Hazelbag; Arko Gorter; Gemma G Kenter; L J C M van den Broek; Gert Jan Fleuren
Transforming growth factor-beta1 induces tumor stroma and reduces tumor infiltrate in cervical cancer.
Human pathology 2002;33(12):1193-9.
2002: Anand G Menon; Hans Morreau; R A E M Tollenaar; E Alphenaar; Marjo Van Puijenbroek; Hein Putter; Connie M Janssen-Van Rhijn; Cornelis J H van de Velde; Gert Jan Fleuren; Peter Kuppen
Down-regulation of HLA-A expression correlates with a better prognosis in colorectal cancer patients.
Laboratory investigation; a journal of technical methods and pathology 2002;82(12):1725-33.
2002: Antoinette A T P Brink; Joop Wiegant; Karoly Szuhai; Hans J Tanke; Gemma G Kenter; Gert Jan Fleuren; Ed Schuuring; Anton K Raap
Simultaneous mapping of human papillomavirus integration sites and molecular karyotyping in short-term cultures of cervical carcinomas by using 49-color combined binary ratio labeling fluorescence in situ hybridization.
Cancer genetics and cytogenetics 2002;134(2):145-50.
2002: Kyra A Gelderman; Vanessa T Blok; Gert Jan Fleuren; Arko Gorter
The inhibitory effect of CD46, CD55, and CD59 on complement activation after immunotherapeutic treatment of cervical carcinoma cells with monoclonal antibodies or bispecific monoclonal antibodies.
Laboratory investigation; a journal of technical methods and pathology 2002;82(4):483-93.
2002: Willem E Corver; Gert Jan Fleuren; Cees J Cornelisse
Software compensation improves the analysis of heterogeneous tumor samples stained for multiparameter DNA flow cytometry.
Journal of immunological methods 2002;260(1-2):97-107.
2002: Kyra A Gelderman; Peter Kuppen; Wouter Bruin; Gert Jan Fleuren; Arko Gorter
Enhancement of the complement activating capacity of 17-1A mAb to overcome the effect of membrane-bound complement regulatory proteins on colorectal carcinoma.
European journal of immunology 2002;32(1):128-35.
2001: Peter Kuppen; Arko Gorter; Muriel A Hagenaars; Liesbeth E Jonges; KM Giezeman-Smits; J Fred Nagelkerke; Gert Jan Fleuren; Cornelis J H van de Velde
Role of NK cells in adoptive immunotherapy of metastatic colorectal cancer in a syngeneic rat model.
Immunological reviews 2001;184():236-43.
2001: Karoly Szuhai; E Sandhaus; Sandra M Kolkman-Uljee; M Lemaître; JC Truffert; Roeland W Dirks; Hans J Tanke; Gert Jan Fleuren; Ed Schuuring; Anton K Raap
A novel strategy for human papillomavirus detection and genotyping with SybrGreen and molecular beacon polymerase chain reaction.
The American journal of pathology 2001;159(5):1651-60.
2001: Suzanne Hazelbag; Gert Jan Fleuren; JJ Baelde; E Schuuring; Gemma G Kenter; Arko Gorter
Cytokine profile of cervical cancer cells.
Gynecologic oncology 2001;83(2):235-43.
2001: Liesbeth E Jonges; J Fred Nagelkerke; N Geeske Ensink; Edo A van der Velde; R A E M Tollenaar; Gert Jan Fleuren; Cornelis J H van de Velde; Hans Morreau; Peter Kuppen
Caspase-3 activity as a prognostic factor in colorectal carcinoma.
Laboratory investigation; a journal of technical methods and pathology 2001;81(5):681-8.
2001: M Balzar; Inge H Briaire-de Bruijn; H A Rees-Bakker; Frans A Prins; Wijnand Helfrich; Lou de Leij; Gert Riethmüller; Saverio Alberti; SO Warnaar; Gert Jan Fleuren; Sergey V Litvinov
Epidermal growth factor-like repeats mediate lateral and reciprocal interactions of Ep-CAM molecules in homophilic adhesions.
Molecular and cellular biology 2001;21(7):2570-80.
2001: Sjoerd H van der burg; Maaike E Ressing; Kitty M C Kwappenberg; Annemieke de Jong; K Straathof; J de Jong; Annemieke Geluk; Krista E van Meijgaarden; Kees L M C Franken; Tom H M Ottenhoff; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief; Rienk Offringa
Natural T-helper immunity against human papillomavirus type 16 (HPV16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: identification of 3 human leukocyte antigen class II-restricted epitopes.
International journal of cancer. Journal international du cancer 2001;91(5):612-8.
2001: R Koelemij; Muriel A Hagenaars; N Geeske Ensink; Alexander M M Eggermont; Cornelis J H van de Velde; Gert Jan Fleuren; Peter Kuppen
Administration of BiMAb-retargeted T cells in a rat hepatic metastases colon tumour model results in T-cell tumour infiltration independent of the route of administration.
Scandinavian journal of immunology 2001;53(3):277-81.
2001: Liesbeth E Jonges; Per Albertsson; Ronald L P van Vlierberghe; N Geeske Ensink; Bengt R Johansson; Cornelis J H van de Velde; Gert Jan Fleuren; Ulf Nannmark; Peter Kuppen
The phenotypic heterogeneity of human natural killer cells: presence of at least 48 different subsets in the peripheral blood.
Scandinavian journal of immunology 2001;53(2):103-10.
2001: Peter Kuppen; Marjolijn M van der Eb; Liesbeth E Jonges; Muriel A Hagenaars; Marianne Hokland; Ulf Nannmark; R H Goldfarb; Per H Basse; Gert Jan Fleuren; Rob Hoeben; Cornelis J H van de Velde
Tumor structure and extracellular matrix as a possible barrier for therapeutic approaches using immune cells or adenoviruses in colorectal cancer.
Histochemistry and cell biology 2001;115(1):67-72.
2000: Bart W J Hellebrekers; A H Zwinderman; Gemma G Kenter; A A W Peters; Gert Jan Fleuren; J Baptist Trimbos
[Surgical treatment of early stage cervical carcinoma at Leids University Medical Center, 1984-1996: depth of invasion, number and bilaterality of metastatic lymph nodes prognostic for recurrence].
Nederlands tijdschrift voor geneeskunde 2000;144(48):2304-9.
2000: Liesbeth E Jonges; KM Giezeman-Smits; Ronald L P van Vlierberghe; N Geeske Ensink; Muriel A Hagenaars; E Joly; Alexander M M Eggermont; Cornelis J H van de Velde; Gert Jan Fleuren; Peter Kuppen
NK cells modulate MHC class I expression on tumor cells and their susceptibility to lysis.
Immunobiology 2000;202(4):326-38.
2000: Nathalie L G Sieben; Natalja T Ter Haar; Cees J Cornelisse; Gert Jan Fleuren; Anne-Marie Cleton-Jansen
PCR artifacts in LOH and MSI analysis of microdissected tumor cells.
Human pathology 2000;31(11):1414-9.
2000: Willem E Corver; LA Koopman; Arend Mulder; Cees J Cornelisse; Gert Jan Fleuren
Distinction between HLA class I-positive and -negative cervical tumor subpopulations by multiparameter DNA flow cytometry.
Cytometry 2000;41(1):73-80.
2000: AM Kersemaekers; Marc J van de Vijver; Gert Jan Fleuren
Comparison of the genetic alterations in two epithelial collision tumors of the uterine cervix. A report of two cases.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2000;19(3):225-30.
2000: BA Bonsing; Willem E Corver; Gert Jan Fleuren; Anne-Marie Cleton-Jansen; Peter Devilee; Cees J Cornelisse
Allelotype analysis of flow-sorted breast cancer cells demonstrates genetically related diploid and aneuploid subpopulations in primary tumors and lymph node metastases.
Genes, chromosomes & cancer 2000;28(2):173-83.
2000: Katja N Gaarenstroom; Gemma G Kenter; Johannes M G Bonfrer; Catharina M Korse; M J Van de Vijver; Gert Jan Fleuren; J Baptist Trimbos
Can initial serum cyfra 21-1, SCC antigen, and TPA levels in squamous cell cervical cancer predict lymph node metastases or prognosis?
Gynecologic oncology 2000;77(1):164-70.
2000: LA Koopman; Willem E Corver; Arno R van der Slik; Marius J Giphart; Gert Jan Fleuren
Multiple genetic alterations cause frequent and heterogeneous human histocompatibility leukocyte antigen class I loss in cervical cancer.
The Journal of experimental medicine 2000;191(6):961-76.
2000: Maaike E Ressing; WJ van Driel; RM Brandt; Gemma G Kenter; J Hans De Jong; T Bauknecht; Gert Jan Fleuren; P Hoogerhout; Rienk Offringa; A Sette; E Celis; Howard Grey; Baptist J Trimbos; W Martin Kast; Cornelis J M Melief
Detection of T helper responses, but not of human papillomavirus-specific cytotoxic T lymphocyte responses, after peptide vaccination of patients with cervical carcinoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(2):255-66.
2000: Willem E Corver; LA Koopman; J van der Aa; M Regensburg; Gert Jan Fleuren; Cees J Cornelisse
Four-color multiparameter DNA flow cytometric method to study phenotypic intratumor heterogeneity in cervical cancer.
Cytometry 2000;39(2):96-107.
2000: Muriel A Hagenaars; R Koelemij; N Geeske Ensink; Jaap van Eendenburg; Ronald L P van Vlierberghe; Alexander M M Eggermont; Cornelis J H van de Velde; Gert Jan Fleuren; Peter Kuppen
The development of novel mouse monoclonal antibodies against the CC531 rat colon adenocarcinoma.
Clinical & experimental metastasis 2000;18(4):281-9.
2000: Muriel A Hagenaars; N Geeske Ensink; Per H Basse; Marianne Hokland; Ulf Nannmark; Alexander M M Eggermont; Cornelis J H van de Velde; Gert Jan Fleuren; Peter Kuppen
The microscopic anatomy of experimental rat CC531 colon tumour metastases: consequences for immunotherapy?
Clinical & experimental metastasis 2000;18(2):189-96.
2000: Muriel A Hagenaars; N Geeske Ensink; Alexander M M Eggermont; Edo A van der Velde; Cornelis J H van de Velde; Gert Jan Fleuren; Peter Kuppen
Endogenous natural killer cells do not play a role in antitumor effects induced by interleukin-2 in a syngeneic rat colon tumor model.
Cancer immunology, immunotherapy : CII 2000;48(10):561-8.
1999: AM Kersemaekers; Marc J van de Vijver; Gemma G Kenter; Gert Jan Fleuren
Genetic alterations during the progression of squamous cell carcinomas of the uterine cervix.
Genes, chromosomes & cancer 1999;26(4):346-54.
1999: R Koelemij; Peter Kuppen; Cornelis J H van de Velde; Gert Jan Fleuren; Muriel A Hagenaars; Alexander M M Eggermont
Bispecific antibodies in cancer therapy, from the laboratory to the clinic.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1999;22(6):514-24.
1999: LA Koopman; Karoly Szuhai; Jaap van Eendenburg; Vladimir Bezrookove; Gemma G Kenter; Ed Schuuring; Hans J Tanke; Gert Jan Fleuren
Recurrent integration of human papillomaviruses 16, 45, and 67 near translocation breakpoints in new cervical cancer cell lines.
Cancer research 1999;59(21):5615-24.
1999: LA Koopman; Arno R van der Slik; Marius J Giphart; Gert Jan Fleuren
Human leukocyte antigen class I gene mutations in cervical cancer.
Journal of the National Cancer Institute 1999;91(19):1669-77.
1999: Eveline J T Krul; AM Kersemaekers; Y A Zomerdijk-Nooyen; Cees J Cornelisse; Lex A W Peters; Gert Jan Fleuren
Different profiles of allelic losses in cervical carcinoma cases in Surinam and The Netherlands.
Cancer 1999;86(6):997-1004.
1999: Conny de Boer; E van Dorst; Han van Krieken; C M Jansen-van Rhijn; SO Warnaar; Gert Jan Fleuren; Sergey V Litvinov
Changing roles of cadherins and catenins during progression of squamous intraepithelial lesions in the uterine cervix.
The American journal of pathology 1999;155(2):505-15.
1999: WJ van Driel; P Kievit-Tyson; LC van den Broek; Aeilko H Zwinderman; Baptist J Trimbos; Gert Jan Fleuren
Presence of an eosinophilic infiltrate in cervical squamous carcinoma results from a type 2 immune response.
Gynecologic oncology 1999;74(2):188-95.
1999: KM Giezeman-Smits; Arko Gorter; Ronald L P van Vlierberghe; J D v Eendenburg; Alexander M M Eggermont; Gert Jan Fleuren; Peter Kuppen
The regulatory role of CD45 on rat NK cells in target cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):71-6.
1999: WJ van Driel; Maaike E Ressing; Gemma G Kenter; RM Brandt; Eveline J T Krul; AB Van Rossum; Ed Schuuring; Rienk Offringa; T Bauknecht; A Tamm-Hermelink; P A van Dam; Gert Jan Fleuren; W Martin Kast; Cornelis J M Melief; J Baptist Trimbos
Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: clinical evaluation of a phase I-II trial.
European journal of cancer (Oxford, England : 1990) 1999;35(6):946-52.
1999: Eveline J T Krul; RF Schipper; G M Th Schreuder; Gert Jan Fleuren; Gemma G Kenter; Cornelis J M Melief
HLA and susceptibility to cervical neoplasia.
Human immunology 1999;60(4):337-42.
1999: AM Kersemaekers; Gert Jan Fleuren; Gemma G Kenter; L J C M van den Broek; S M Uljee; Jo Hermans; Marc J van de Vijver
Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):577-86.
1999: Muriel A Hagenaars; N Geeske Ensink; Liesbeth E Jonges; William Chambers; Alexander M M Eggermont; Cornelis J H van de Velde; Gert Jan Fleuren; Peter Kuppen
The development of a bi-specific anti-CD161A x anti-tumor antibody for rat NK cell targeting.
Immunobiology 1999;200(1):31-48.
1999: WJ van Driel; Gemma G Kenter; Gert Jan Fleuren; Cornelis J M Melief; Baptist J Trimbos
Immunotherapeutic strategies for cervical squamous carcinoma.
Hematology/oncology clinics of North America 1999;13(1):259-73.
1999: M Balzar; Frans A Prins; HA Bakker; Gert Jan Fleuren; SO Warnaar; Sergey V Litvinov
The structural analysis of adhesions mediated by Ep-CAM.
Experimental cell research 1999;246(1):108-21.
1998: Muriel A Hagenaars; Sander Zwaveling; Peter Kuppen; N Geeske Ensink; Alexander M M Eggermont; Marianne Hokland; Per H Basse; Cornelis J H van de Velde; Gert Jan Fleuren; Ulf Nannmark
Characteristics of tumor infiltration by adoptively transferred and endogenous natural-killer cells in a syngeneic rat model: implications for the mechanism behind anti-tumor responses.
International journal of cancer. Journal international du cancer 1998;78(6):783-9.
1998: E B van Dorst; G N van Muijen; Sergey V Litvinov; Gert Jan Fleuren
The limited difference between keratin patterns of squamous cell carcinomas and adenocarcinomas is explicable by both cell lineage and state of differentiation of tumour cells.
Journal of clinical pathology 1998;51(9):679-84.
1998: AM Kersemaekers; Gemma G Kenter; Jo Hermans; Gert Jan Fleuren; Marc J van de Vijver
Allelic loss and prognosis in carcinoma of the uterine cervix.
International journal of cancer. Journal international du cancer 1998;79(4):411-7.
1998: M P Velders; C M van Rhijn; E Oskam; Gert Jan Fleuren; SO Warnaar; Sergey V Litvinov
The impact of antigen density and antibody affinity on antibody-dependent cellular cytotoxicity: relevance for immunotherapy of carcinomas.
British journal of cancer 1998;78(4):478-83.
1998: M Balzar; HA Bakker; Inge H Briaire-de Bruijn; Gert Jan Fleuren; SO Warnaar; Sergey V Litvinov
Cytoplasmic tail regulates the intercellular adhesion function of the epithelial cell adhesion molecule.
Molecular and cellular biology 1998;18(8):4833-43.
1998: LA Koopman; Arend Mulder; Willem E Corver; Jacqy D H Anholts; Marius J Giphart; Frans H J Claas; Gert Jan Fleuren
HLA class I phenotype and genotype alterations in cervical carcinomas and derivative cell lines.
Tissue antigens 1998;51(6):623-36.
1998: Vanessa T Blok; Mohamed R Daha; Odette Tijsma; C L Harris; B P Morgan; Gert Jan Fleuren; Arko Gorter
A bispecific monoclonal antibody directed against both the membrane-bound complement regulator CD55 and the renal tumor-associated antigen G250 enhances C3 deposition and tumor cell lysis by complement.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3437-43.
1998: KM Giezeman-Smits; Liesbeth E Jonges; William Chambers; C S Brisette-Storkus; Ronald L P van Vlierberghe; Jaap van Eendenburg; Alexander M M Eggermont; Gert Jan Fleuren; Peter Kuppen
Novel monoclonal antibodies against membrane structures that are preferentially expressed on IL-2-activated rat NK cells.
Journal of leukocyte biology 1998;63(2):209-15.
1998: Muriel A Hagenaars; N Geeske Ensink; R Koelemij; Per H Basse; Alexander M M Eggermont; Cornelis J H van de Velde; Gert Jan Fleuren; Peter Kuppen
Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration.
International journal of cancer. Journal international du cancer 1998;75(2):233-8.
1998: AM Kersemaekers; Jo Hermans; Gert Jan Fleuren; Marc J van de Vijver
Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix.
British journal of cancer 1998;77(2):192-200.
1997: Edwin Abeln; V T Smit; J W Wessels; W J de Leeuw; Cees J Cornelisse; Gert Jan Fleuren
Molecular genetic evidence for the conversion hypothesis of the origin of malignant mixed müllerian tumours.
The Journal of pathology 1997;183(4):424-31.
1997: Sergey V Litvinov; M Balzar; Manon J Winter; HA Bakker; Inge H Briaire-de Bruijn; Frans A Prins; Gert Jan Fleuren; SO Warnaar
Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins.
The Journal of cell biology 1997;139(5):1337-48.
1997: KM Giezeman-Smits; Arko Gorter; J Fred Nagelkerke; Ronald L P van Vlierberghe; Jaap van Eendenburg; Alexander M M Eggermont; Gert Jan Fleuren; Peter Kuppen
Characterization of three new membrane structures on rat NK cells which are involved in activation of the lytic machinery.
Immunobiology 1997;197(5):429-43.
1997: MJ Kagie; Gemma G Kenter; Y Zomerdijk-Nooijen; Jo Hermans; E Schuuring; Petra Timmers; J Baptist Trimbos; Gert Jan Fleuren
Human papillomavirus infection in squamous cell carcinoma of the vulva, in various synchronous epithelial changes and in normal vulvar skin.
Gynecologic oncology 1997;67(2):178-83.
1997: MJ Kagie; Gemma G Kenter; RA Tollenaar; Jo Hermans; J Baptist Trimbos; Gert Jan Fleuren
p53 protein overexpression is common and independent of human papillomavirus infection in squamous cell carcinoma of the vulva.
Cancer 1997;80(7):1228-33.
1997: Michel P M Vierboom; H W Nijman; Rienk Offringa; Ellen I H van der Voort; Thorbald van Hall; L van den Broek; Gert Jan Fleuren; P Kenemans; W M Kast; Cornelis J M Melief
Tumor eradication by wild-type p53-specific cytotoxic T lymphocytes.
The Journal of experimental medicine 1997;186(5):695-704.
1997: Willem E Corver; Gert Jan Fleuren; Cees J Cornelisse
Improved single laser measurement of two cellular antigens and DNA-ploidy by the combined use of propidium iodide and TO-PRO-3 iodide.
Cytometry 1997;28(4):329-36.
1997: BA Bonsing; Willem E Corver; M C Gorsira; M van Vliet; P S Oud; Cees J Cornelisse; Gert Jan Fleuren
Specificity of seven monoclonal antibodies against p53 evaluated with Western blotting, immunohistochemistry, confocal laser scanning microscopy, and flow cytometry.
Cytometry 1997;28(1):11-24.
1997: MJ Kagie; Gemma G Kenter; RA Tollenaar; Jo Hermans; J P Trimbos; Gert Jan Fleuren
p53 protein overexpression, a frequent observation in squamous cell carcinoma of the vulva and in various synchronous vulvar epithelia, has no value as a prognostic parameter.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1997;16(2):124-30.
1997: RA Tollenaar; BA Bonsing; Nel J Kuipers-Dijkshoorn; Jo Hermans; Cornelis J H van de Velde; Cees J Cornelisse; Gert Jan Fleuren
Evidence of clonal divergence in colorectal carcinoma.
Cancer 1997;79(7):1304-14.
1997: Hans-Marten Hazelbag; L J C M van den Broek; Gert Jan Fleuren; Antonie H M Taminiau; Pancras Hogendoorn
Distribution of extracellular matrix components in adamantinoma of long bones suggests fibrous-to-epithelial transformation.
Human pathology 1997;28(2):183-8.
1997: MJ Kagie; Gemma G Kenter; Jo Hermans; J Baptist Trimbos; Gert Jan Fleuren
The relevance of various vulvar epithelial changes in the early detection of squamous cell carcinoma of the vulva.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 1997;7(1):50-7.
1997: R M Luiten; SO Warnaar; J Schuurman; S G Pasmans; S Latour; M Daëron; Gert Jan Fleuren; Sergey V Litvinov
Chimeric immunoglobulin E reactive with tumor-associated antigen activates human Fc epsilon RI bearing cells.
Human antibodies 1997;8(4):169-80.
1996: R L van Bezooijen; H Goey; Gerrit Stoter; J Hermans; Gert Jan Fleuren
Prognostic markers for survival in patients with metastatic renal cell carcinoma treated with interleukin-2.
Cancer immunology, immunotherapy : CII 1996;43(5):293-8.
1996: WJ van Driel; Maaike E Ressing; RM Brandt; René E M Toes; Gert Jan Fleuren; J B Trimbos; W Martin Kast; Cornelis J M Melief
The current status of therapeutic HPV vaccine.
Annals of medicine 1996;28(6):471-7.
1996: Willem E Corver; BA Bonsing; Edwin Abeln; P M Vlak-Theil; Cees J Cornelisse; Gert Jan Fleuren
One-tube triple staining method for flow cytometric analysis of DNA ploidy and phenotypic heterogeneity of human solid tumors using single laser excitation.
Cytometry 1996;25(4):358-66.
1996: WJ van Driel; Pancras Hogendoorn; F W Jansen; A H Zwinderman; J Baptist Trimbos; Gert Jan Fleuren
Tumor-associated eosinophilic infiltrate of cervical cancer is indicative for a less effective immune response.
Human pathology 1996;27(9):904-11.
1996: R M Luiten; L R Coney; Gert Jan Fleuren; SO Warnaar; Sergey V Litvinov
Generation of chimeric bispecific G250/anti-CD3 monoclonal antibody, a tool to combat renal cell carcinoma.
British journal of cancer 1996;74(5):735-44.
1996: KM Giezeman-Smits; Peter Kuppen; N Geeske Ensink; Alexander M M Eggermont; F Stals; K Wonigeit; Gert Jan Fleuren
The role of MHC class I expression in rat NK cell-mediated lysis of syngeneic tumor cells and virus-infected cells.
Immunobiology 1996;195(3):286-99.
1996: M P Velders; C M van Rhijn; I M H A Cornelissen; G N van Muijen; I H Briaire; M Dohlsten; Gert Jan Fleuren; SO Warnaar; Sergey V Litvinov
The role of monoclonal antibody affinity in tumor immunotherapy evaluated in in vivo models for minimal residual disease.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1996;19(4):245-56.
1996: J A Schueler; J Baptist Trimbos; M vd Burg; Cees J Cornelisse; J Hermans; Gert Jan Fleuren
DNA index reflects the biological behavior of ovarian carcinoma stage I-IIa.
Gynecologic oncology 1996;62(1):59-66.
1996: WJ van Driel; M Y Tjiong; C G Hilders; Baptist J Trimbos; Gert Jan Fleuren
Association of allele-specific HLA expression and histopathologic progression of cervical carcinoma.
Gynecologic oncology 1996;62(1):33-41.
1996: Arko Gorter; V T Blok; W H Haasnoot; N G Ensink; Mohamed R Daha; Gert Jan Fleuren
Expression of CD46, CD55, and CD59 on renal tumor cell lines and their role in preventing complement-mediated tumor cell lysis.
Laboratory investigation; a journal of technical methods and pathology 1996;74(6):1039-49.
1996: Gemma G Kenter; E M Schoonderwald; I A Koelma; N Arentz; J Hermans; Gert Jan Fleuren
The cytological screening history of 469 patients with squamous cell carcinoma of the cervix uteri; does interval carcinoma exist?
Acta obstetricia et gynecologica Scandinavica 1996;75(4):400-3.
1996: E J Krul; L A Peters; J P Vandenbroucke; A Vrede; R W van Kanten; Gert Jan Fleuren
Cervical carcinoma in Surinam. Incidence and staging of cervical carcinoma between 1989 and 1994.
Cancer 1996;77(7):1329-33.
1996: Sergey V Litvinov; WJ van Driel; C M van Rhijn; H A Bakker; H van Krieken; Gert Jan Fleuren; SO Warnaar
Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation.
The American journal of pathology 1996;148(3):865-75.
1996: R M Luiten; Gert Jan Fleuren; SO Warnaar; Sergey V Litvinov
Target-specific activation of mast cells by immunoglobulin E reactive with a renal cell carcinoma-associated antigen.
Laboratory investigation; a journal of technical methods and pathology 1996;74(2):467-75.
1996: Maaike E Ressing; WJ van Driel; E Celis; Alessandro Sette; M P Brandt; M Hartman; J D Anholts; G M Th Schreuder; W B ter Harmsel; Gert Jan Fleuren; Baptist J Trimbos; W Martin Kast; Cornelis J M Melief
Occasional memory cytotoxic T-cell responses of patients with human papillomavirus type 16-positive cervical lesions against a human leukocyte antigen-A *0201-restricted E7-encoded epitope.
Cancer research 1996;56(3):582-8.
1995: Hans-Marten Hazelbag; Gert Jan Fleuren; Cees J Cornelisse; L J C M van den Broek; Antonie H M Taminiau; Pancras Hogendoorn
DNA aberrations in the epithelial cell component of adamantinoma of long bones.
The American journal of pathology 1995;147(6):1770-9.
1995: Edwin Abeln; Nel J Kuipers-Dijkshoorn; Petronella Berns; SC Henzen-Logmans; Gert Jan Fleuren; Cees J Cornelisse
Molecular genetic evidence for unifocal origin of advanced epithelial ovarian cancer and for minor clonal divergence.
British journal of cancer 1995;72(5):1330-6.
1995: M P Velders; C M van Rhijn; I H Briaire; Gert Jan Fleuren; SO Warnaar; Sergey V Litvinov
Immunotherapy with low and high affinity monoclonal antibodies 17-1A and 323/A3 in a nude mouse xenograft carcinoma model.
Cancer research 1995;55(19):4398-403.
1995: H H van Ravenswaay Claasen; Gert Jan Fleuren
The influence of combination chemotherapy on antigen expression in ovarian cancer.
Gynecologic oncology 1995;58(1):16-23.
1995: C G Hilders; I M Munoz; Y Nooyen; Gert Jan Fleuren
Altered HLA expression by metastatic cervical carcinoma cells as a factor in impaired immune surveillance.
Gynecologic oncology 1995;57(3):366-75.
1995: Gert Jan Fleuren; Arko Gorter; Peter Kuppen; Sergey V Litvinov; SO Warnaar
Tumor heterogeneity and immunotherapy of cancer.
Immunological reviews 1995;145():91-122.
1995: Hans-Marten Hazelbag; L J C M van den Broek; E B van Dorst; G Johan A Offerhaus; Gert Jan Fleuren; Pancras Hogendoorn
Immunostaining of chain-specific keratins on formalin-fixed, paraffin-embedded tissues: a comparison of various antigen retrieval systems using microwave heating and proteolytic pre-treatments.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995;43(4):429-37.
1995: Willem E Corver; Cees J Cornelisse; J Hermans; Gert Jan Fleuren
Limited loss of nine tumor-associated surface antigenic determinants after tryptic cell dissociation.
Cytometry 1995;19(3):267-72.
1994: Hans-Marten Hazelbag; Antonie H M Taminiau; Gert Jan Fleuren; Pancras Hogendoorn
Adamantinoma of the long bones. A clinicopathological study of thirty-two patients with emphasis on histological subtype, precursor lesion, and biological behavior.
The Journal of bone and joint surgery. American volume 1994;76(10):1482-99.
1994: Peter Devilee; EM van Schothorst; A F Bardoel; BA Bonsing; Nel J Kuipers-Dijkshoorn; MR James; Gert Jan Fleuren; Andel G L van der Mey; Cees J Cornelisse
Allelotype of head and neck paragangliomas: allelic imbalance is confined to the long arm of chromosome 11, the site of the predisposing locus PGL.
Genes, chromosomes & cancer 1994;11(2):71-8.
1994: Edwin Abeln; Willem E Corver; Nel J Kuipers-Dijkshoorn; Gert Jan Fleuren; Cees J Cornelisse
Molecular genetic analysis of flow-sorted ovarian tumour cells: improved detection of loss of heterozygosity.
British journal of cancer 1994;70(2):255-62.
1994: M L van Velthuysen; A E Mayen; N van Rooijen; Gert Jan Fleuren; Emile de Heer; Jan A Bruijn
T cells and macrophages in Trypanosoma brucei-related glomerulopathy.
Infection and immunity 1994;62(8):3230-5.
1994: C G Hilders; L Ras; Jaap van Eendenburg; Y Nooyen; Gert Jan Fleuren
Isolation and characterization of tumor-infiltrating lymphocytes from cervical carcinoma.
International journal of cancer. Journal international du cancer 1994;57(6):805-13.
1994: C M van Duinen; L J van den Broek; Bert-Jan Vermeer; Gert Jan Fleuren; Jan A Bruijn
The distribution of cellular adhesion molecules in pigmented skin lesions.
Cancer 1994;73(8):2131-9.
1994: Sergey V Litvinov; M P Velders; H A Bakker; Gert Jan Fleuren; SO Warnaar
Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule.
The Journal of cell biology 1994;125(2):437-46.
1994: M P Velders; Sergey V Litvinov; SO Warnaar; Arko Gorter; Gert Jan Fleuren; V R Zurawski; L R Coney
New chimeric anti-pancarcinoma monoclonal antibody with superior cytotoxicity-mediating potency.
Cancer research 1994;54(7):1753-9.
1994: L J C M van den Broek; Hans-Marten Hazelbag; C G Hilders; Gert Jan Fleuren
Antigen retrieval and microwaving.
European journal of morphology 1994;32(1):65-70.
1994: Peter Kuppen; Per H Basse; Ronald H Goldfarb; Cornelis J H van de Velde; Gert Jan Fleuren; Alexander M M Eggermont
The infiltration of experimentally induced lung metastases of colon carcinoma CC531 by adoptively transferred interleukin-2-activated natural killer cells in Wag rats.
International journal of cancer. Journal international du cancer 1994;56(4):574-9.
1994: Willem E Corver; Cees J Cornelisse; Gert Jan Fleuren
Simultaneous measurement of two cellular antigens and DNA using fluorescein-isothiocyanate, R-phycoerythrin, and propidium iodide on a standard FACScan.
Cytometry 1994;15(2):117-28.
1994: J van Dijk; H Uemura; A J Beniers; W P Peelen; S T Zegveld; Gert Jan Fleuren; SO Warnaar; Egbert Oosterwijk
Therapeutic effects of monoclonal antibody G250, interferons and tumor necrosis factor, in mice with renal-cell carcinoma xenografts.
International journal of cancer. Journal international du cancer 1994;56(2):262-8.
1994: F C Twaalfhoven; Gert Jan Fleuren; Cees J Cornelisse; A A Peters; J Baptist Trimbos; Pancras Hogendoorn
Metastasis of breast carcinoma to a primary mucinous cystadenocarcinoma of the ovary.
Gynecologic oncology 1994;52(1):80-6.
1994: Peter Kuppen; Alexander M M Eggermont; R B Quak; A Marinelli; Cornelis J H van de Velde; Gert Jan Fleuren
Soluble factors produced by macrophages/monocytes inhibit lymphokine-activated killer activity in rat splenocyte cultures.
Cancer immunology, immunotherapy : CII 1994;38(1):61-7.
1994: K M Smits; Peter Kuppen; Alexander M M Eggermont; T Tamatani; M Miyasaka; Gert Jan Fleuren
Rat interleukin-2-activated natural killer (A-NK) cell-mediated lysis is determined by the presence of CD18 on A-NK cells and the absence of major histocompatibility complex class I on target cells.
European journal of immunology 1994;24(1):171-5.
1994: M L van Velthuysen; A E Mayen; Frans A Prins; Emile de Heer; Jan A Bruijn; Gert Jan Fleuren
Phagocytosis by glomerular endothelial cells in infection-related glomerulopathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1994;9(8):1077-83.
1994: C M Van Duinen; Gert Jan Fleuren; Jan A Bruijn
The extracellular matrix in pigmented skin lesions: an immunohistochemical study.
Histopathology 1994;24(1):33-40.
1994: C G Hilders; J G Houbiers; E J Krul; Gert Jan Fleuren
The expression of histocompatibility-related leukocyte antigens in the pathway to cervical carcinoma.
American journal of clinical pathology 1994;101(1):5-12.
1993: C G Hilders; J G Houbiers; H H van Ravenswaay Claasen; R W Veldhuizen; Gert Jan Fleuren
Association between HLA-expression and infiltration of immune cells in cervical carcinoma.
Laboratory investigation; a journal of technical methods and pathology 1993;69(6):651-9.
1993: Hans-Marten Hazelbag; Gert Jan Fleuren; L J vd Broek; Antonie H M Taminiau; Pancras Hogendoorn
Adamantinoma of the long bones: keratin subclass immunoreactivity pattern with reference to its histogenesis.
The American journal of surgical pathology 1993;17(12):1225-33.
1993: K M Smits; Peter Kuppen; Alexander M M Eggermont; Gert Jan Fleuren
Preincubation of tumor cells with the anti-(MHC) class I antibody OX18 enhances tumor cell lysis by interleukin-2-activated NK cells.
Transplantation proceedings 1993;25(5):2806-7.
1993: K M Smits; Peter Kuppen; S P Lazeroms; Alexander M M Eggermont; Gert Jan Fleuren
Major histocompatibility complex class I expression and sensitivity to interleukin-2 activated NK cell-mediated lysis of adenovirus-transformed baby rat kidney cells.
Transplantation proceedings 1993;25(5):2804-5.
1993: H H van Ravenswaay Claasen; R J van de Griend; D Mezzanzanica; R L Bolhuis; SO Warnaar; Gert Jan Fleuren
Analysis of production, purification, and cytolytic potential of bi-specific antibodies reactive with ovarian-carcinoma-associated antigens and the T-cell antigen CD3.
International journal of cancer. Journal international du cancer 1993;55(1):128-36.
1993: BA Bonsing; Peter Devilee; Anne-Marie Cleton-Jansen; Nel J Kuipers-Dijkshoorn; Gert Jan Fleuren; Cees J Cornelisse
Evidence for limited molecular genetic heterogeneity as defined by allelotyping and clonal analysis in nine metastatic breast carcinomas.
Cancer research 1993;53(16):3804-11.
1993: G D Beun; Cornelis J H van de Velde; Gert Jan Fleuren; Alexander M M Eggermont
T-cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model: IV. Tumor neutralization in Winn type assays.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(1):11-5.
1993: Peter Kuppen; Alexander M M Eggermont; K M Smits; Jaap van Eendenburg; S P Lazeroms; Cornelis J H van de Velde; Gert Jan Fleuren
The development and purification of a bispecific antibody for lymphokine-activated killer cell targeting against the rat colon carcinoma CC531.
Cancer immunology, immunotherapy : CII 1993;36(6):403-8.
1993: Arko Gorter; R J van de Griend; Jaap van Eendenburg; W H Haasnoot; Gert Jan Fleuren
Production of bi-specific monoclonal antibodies in a hollow-fibre bioreactor.
Journal of immunological methods 1993;161(2):145-50.
1993: G D Beun; Arko Gorter; Y Nooyen; Cornelis J H van de Velde; Gert Jan Fleuren
T cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. II. Syngeneic colon carcinoma CC531 is efficiently killed by retargeted cytotoxic T lymphocytes in vitro despite limited lysis in 51Cr release assays.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(6):2305-15.
1993: M L van Velthuysen; A Veninga; Jan A Bruijn; Emile de Heer; Gert Jan Fleuren
Susceptibility for infection-related glomerulopathy depends on non-MHC genes.
Kidney international 1993;43(3):623-9.
1993: J A Schueler; Cees J Cornelisse; J Hermans; J Baptist Trimbos; M E van der Burg; Gert Jan Fleuren
Prognostic factors in well-differentiated early-stage epithelial ovarian cancer.
Cancer 1993;71(3):787-95.
1993: BA Bonsing; H Beerman; Nel J Kuipers-Dijkshoorn; Gert Jan Fleuren; Cees J Cornelisse
High levels of DNA index heterogeneity in advanced breast carcinomas. Evidence for DNA ploidy differences between lymphatic and hematogenous metastases.
Cancer 1993;71(2):382-91.
1993: Gemma G Kenter; Cees J Cornelisse; N M Jiwa; E J Aartsen; J Hermans; W Mooi; A Peter M Heintz; Gert Jan Fleuren
Human papillomavirus type 16 in tumor tissue of low-stage squamous carcinoma of the uterine cervix in relation to ploidy grade and prognosis.
Cancer 1993;71(2):397-401.
1993: Pancras Hogendoorn; E B van Dorst; Sjoerd H van der burg; Jan A Bruijn; Mohamed R Daha; P J Hoedemaeker; Gert Jan Fleuren
Antigen size influences the type of glomerular pathology in chronic serum sickness.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1993;8(8):703-10.
1992: Peter Kuppen; A Marinelli; J A Camps; Ernest K J Pauwels; Cornelis J H van de Velde; Gert Jan Fleuren; Alexander M M Eggermont
Biodistribution of lymphokine-activated killer (LAK) cells in Wag rats after hepatic-artery or jugular-vein infusion.
International journal of cancer. Journal international du cancer 1992;52(2):266-70.
1992: H H van Ravenswaay Claasen; Philip M Kluin; Gert Jan Fleuren
Tumor infiltrating cells in human cancer. On the possible role of CD16+ macrophages in antitumor cytotoxicity.
Laboratory investigation; a journal of technical methods and pathology 1992;67(2):166-74.
1992: G D Beun; D H van Eendenburg; Willem E Corver; Cornelis J H van de Velde; Gert Jan Fleuren
T-cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. I. Significant bispecific lysis of syngeneic colon carcinoma CC531 is critically dependent on prolonged preactivation of effector T-lymphocytes by immobilized anti-T-cell receptor antibody.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1992;11(4):238-48.
1992: Arko Gorter; K M Krüse; Peter I Schrier; Gert Jan Fleuren; R J van de Griend
Enhancement of the lytic activity of cloned human CD8 tumour-infiltrating lymphocytes by bispecific monoclonal antibodies.
Clinical and experimental immunology 1992;87(1):111-6.
1992: Jan Aten; R J Stet; Josee Wagenaar-Hilbers; Jan J Weening; Gert Jan Fleuren; P Nieuwenhuis
Glomerulopathy induced by graft-versus-host reaction in the rat. Requirement of donor CD4+ T lymphocytes and MHC class II incompatibility at the lymphoid compartment.
Scandinavian journal of immunology 1992;35(1):93-105.
1992: M L van Velthuysen; Jan A Bruijn; E H van Leer; Gert Jan Fleuren
Pathogenesis of trypanosomiasis-induced glomerulonephritis in mice.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1992;7(6):507-15.
1991: J van Dijk; S T Zegveld; Gert Jan Fleuren; SO Warnaar
Localization of monoclonal antibody G250 and bispecific monoclonal antibody CD3/G250 in human renal-cell carcinoma xenografts: relative effects of size and affinity.
International journal of cancer. Journal international du cancer 1991;48(5):738-43.
1991: F C Twaalfhoven; A A Peters; J Baptist Trimbos; J Hermans; Gert Jan Fleuren
The accuracy of frozen section diagnosis of ovarian tumors.
Gynecologic oncology 1991;41(3):189-92.
1991: Andel G L van der Mey; Cees J Cornelisse; J Hermans; J L Terpstra; P H Schmidt; Gert Jan Fleuren
DNA flow cytometry of hereditary and sporadic paragangliomas (glomus tumours).
British journal of cancer 1991;63(2):298-302.
1991: J Baptist Trimbos; J A Schueler; M van der Burg; J Hermans; M van Lent; A Peter M Heintz; Gert Jan Fleuren
Watch and wait after careful surgical treatment and staging in well-differentiated early ovarian cancer.
Cancer 1991;67(3):597-602.
1991: P J Hoedemaeker; J Aten; Pancras Hogendoorn; K Kawasaki; E H van Leer; Emile de Heer; Gert Jan Fleuren
Pathogenesis of glomerulonephritis: experimental models revisited.
Advances in nephrology from the Necker Hospital 1991;20():73-90.
1991: Peter Kuppen; Alexander M M Eggermont; A Marinelli; E de Heer; Cornelis J H van de Velde; Gert Jan Fleuren
Induction of lymphokine-activated killer activity in rat splenocyte cultures: the importance of 2-mercaptoethanol and indomethacin.
Cancer immunology, immunotherapy : CII 1991;33(1):28-32.
1991: G Johan A Offerhaus; Francis M Giardiello; J A Bruijn; T Stijnen; E N Molyvas; Gert Jan Fleuren
The value of immunohistochemistry for collagen IV expression in colorectal carcinomas.
Cancer 1991;67(1):99-105.
1990: J Baptist Trimbos; A A Peters; G G Kenter; M A Nooy; Gert Jan Fleuren
[Lessons from gynecological-pathological discussions].
Nederlands tijdschrift voor geneeskunde 1990;134(49):2399-401.
1990: Gemma G Kenter; Cees J Cornelisse; E J Aartsen; W Mooy; J Hermans; A Peter M Heintz; Gert Jan Fleuren
DNA ploidy level as prognostic factor in low stage carcinoma of the uterine cervix.
Gynecologic oncology 1990;39(2):181-5.
1990: Vincent T H B M Smit; Gert Jan Fleuren; Johannes C van Houwelingen; S T Zegveld; Nel J Kuipers-Dijkshoorn; Cees J Cornelisse
Flow cytometric DNA-ploidy analysis of synchronously occurring multiple malignant tumors of the female genital tract.
Cancer 1990;66(8):1843-9.
1990: Jan A Bruijn; E H van Leer; Hans J Baelde; Willem E Corver; Pancras Hogendoorn; Gert Jan Fleuren
Characterization and in vivo transfer of nephritogenic autoantibodies directed against dipeptidyl peptidase IV and laminin in experimental lupus nephritis.
Laboratory investigation; a journal of technical methods and pathology 1990;63(3):350-9.
1990: J Baptist Trimbos; J A Schueler; M van Lent; J Hermans; Gert Jan Fleuren
Reasons for incomplete surgical staging in early ovarian carcinoma.
Gynecologic oncology 1990;37(3):374-7.
1990: Jan A Bruijn; Pancras Hogendoorn; Willem E Corver; L J van den Broek; P J Hoedemaeker; Gert Jan Fleuren
Pathogenesis of experimental lupus nephritis: a role for anti-basement membrane and anti-tubular brush border antibodies in murine chronic graft-versus-host disease.
Clinical and experimental immunology 1990;79(1):115-22.
1990: Pancras Hogendoorn; Jan A Bruijn; E W Gelok; L J Van den Broek; Gert Jan Fleuren
Development of progressive glomerulosclerosis in experimental chronic serum sickness.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1990;5(2):100-9.
1989: Jan A Bruijn; P J Hoedemaeker; Gert Jan Fleuren
Pathogenesis of anti-basement membrane glomerulopathy and immune-complex glomerulonephritis: dichotomy dissolved.
Laboratory investigation; a journal of technical methods and pathology 1989;61(5):480-8.
1989: J Van Dijk; T Tsuruo; D M Segal; R L Bolhuis; R Colognola; R J van de Griend; Gert Jan Fleuren; SO Warnaar
Bispecific antibodies reactive with the multidrug-resistance-related glycoprotein and CD3 induce lysis of multidrug-resistant tumor cells.
International journal of cancer. Journal international du cancer 1989;44(4):738-43.
1989: Jan A Bruijn; E H Van Elven; Willem E Corver; M Oudshoorn-Snoek; Gert Jan Fleuren
Genetics of experimental lupus nephritis: non-H-2 factors determine susceptibility for renal involvement in murine chronic graft-versus-host disease.
Clinical and experimental immunology 1989;76(2):284-9.
1989: J van Dijk; SO Warnaar; Jaap van Eendenburg; M Thienpont; Eric Braakman; J H Boot; Gert Jan Fleuren; R L Bolhuis
Induction of tumor-cell lysis by bi-specific monoclonal antibodies recognizing renal-cell carcinoma and CD3 antigen.
International journal of cancer. Journal international du cancer 1989;43(2):344-9.
1988: I A Koelma; Marius Nap; G J van Steenis; Gert Jan Fleuren
Tumor markers for ovarian cancer. A comparative immunohistochemical and immunocytochemical study of two commercial monoclonal antibodies (OV632 and OC125).
American journal of clinical pathology 1988;90(4):391-6.
1988: Vincent T H B M Smit; Cees J Cornelisse; D De Jong; N J Dijkshoorn; A A Peters; Gert Jan Fleuren
Analysis of tumor heterogeneity in a patient with synchronously occurring female genital tract malignancies by DNA flow cytometry, DNA fingerprinting, and immunohistochemistry.
Cancer 1988;62(6):1146-52.
1988: S Angeli; I A Koelma; Gert Jan Fleuren; G J Van Steenis
Malignant melanoma in fine needle aspirates and effusions. An immunocytochemical study using monoclonal antibodies.
Acta cytologica 1988;32(5):707-12.
1988: Vincent T H B M Smit; A J Boot; A M Smits; Gert Jan Fleuren; Cees J Cornelisse; Johannes L Bos
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas.
Nucleic acids research 1988;16(16):7773-82.
1988: Gert Jan Fleuren; Marius Nap
Carcinoembryonic antigen in primary and metastatic ovarian tumors.
Gynecologic oncology 1988;30(3):407-15.
1988: J van Dijk; Egbert Oosterwijk; M J van Kroonenburgh; U Jonas; Gert Jan Fleuren; Ernest K J Pauwels; SO Warnaar
Perfusion of tumor-bearing kidneys as a model for scintigraphic screening of monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1988;29(6):1078-82.
1988: Jan A Bruijn; E H van Elven; Pancras Hogendoorn; Willem E Corver; P J Hoedemaeker; Gert Jan Fleuren
Murine chronic graft-versus-host disease as a model for lupus nephritis.
The American journal of pathology 1988;130(3):639-41.
1988: Pancras Hogendoorn; Jan A Bruijn; L J vd Broek; Emile de Heer; Jean-Michel Foidart; P J Hoedemaeker; Gert Jan Fleuren
Antibodies to purified renal tubular epithelial antigens contain activity against laminin, fibronectin, and type IV collagen.
Laboratory investigation; a journal of technical methods and pathology 1988;58(3):278-86.
1988: C J Rodenburg; Cees J Cornelisse; J Hermans; Gert Jan Fleuren
DNA flow cytometry and morphometry as prognostic indicators in advanced ovarian cancer: a step forward in predicting the clinical outcome.
Gynecologic oncology 1988;29(2):176-87.
1988: C J Rodenburg; I A Koelma; Marius Nap; Gert Jan Fleuren
Immunohistochemical detection of the ras oncogene product p21 in advanced ovarian cancer. Lack of correlation with clinical outcome.
Archives of pathology & laboratory medicine 1988;112(2):151-4.
1988: G Maes; Gert Jan Fleuren; J Bara; Marius Nap
The distribution of mucins, carcinoembryonic antigen, and mucus-associated antigens in endocervical and endometrial adenocarcinomas.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1988;7(2):112-22.
1987: Gert Jan Fleuren; Marius Nap; J G Aalders; J Baptist Trimbos; Henk W A de Bruijn
Explanation of the limited correlation between tumor CA 125 content and serum CA 125 antigen levels in patients with ovarian tumors.
Cancer 1987;60(10):2437-42.
1987: Jan A Bruijn; Barry Oemar; J H Ehrich; J M Foidart; Gert Jan Fleuren
Anti-basement membrane glomerulopathy in experimental trypanosomiasis.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(7):2482-8.
1987: I A Koelma; Marius Nap; C J Rodenburg; Gert Jan Fleuren
The value of tumour marker CA 125 in surgical pathology.
Histopathology 1987;11(3):287-94.
1987: J A Bruijn; V T Smit; D G Que; Gert Jan Fleuren
Immunohistology of a sarcomatous mural nodule in an ovarian mucinous cystadenocarcinoma.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1987;6(3):287-93.