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Jeffrey Flier

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Jeffrey S Flier
Creating a Nobel culture.
Jeffrey S Flier
Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21.
Ffolliott M Fisher; Jeffrey S Flier; Elliott C Fox; Alexei Kharitonenkov; Sandra Kleiner; Eleftheria Maratos-Flier; Rina J Mepani; Francisco Verdeguer; Jun Wu; Nicholas Douris; Bruce M Spiegelman
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.

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All Publications

2013: Jeffrey S Flier
Creating a Nobel culture.
Science (New York, N.Y.) 2013;339(6116):140-1.
2012: Jeffrey S Flier
Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21.
The Yale journal of biology and medicine 2012;85(3):405-14.
2012: Ffolliott M Fisher; Jeffrey S Flier; Elliott C Fox; Alexei Kharitonenkov; Sandra Kleiner; Eleftheria Maratos-Flier; Rina J Mepani; Francisco Verdeguer; Jun Wu; Nicholas Douris; Bruce M Spiegelman
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.
Genes & development 2012;26(3):271-81.
2011: Artur Czupryn; Jeffrey S Flier; Matthew Peter Anderson; Xi Chen; David McNay; Yu-Dong Zhou; Jeffrey D Macklis
Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice.
Science (New York, N.Y.) 2011;334(6059):1133-7.
2011: Ffolliott M Fisher; Jeffrey S Flier; Alexei Kharitonenkov; Andrew C Adams; Patrick J Antonellis; Holly A Bina; Jennifer L Estall; Bruce M Spiegelman; Eleftheria Maratos-Flier
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.
Endocrinology 2011;152(8):2996-3004.
2011: Nabila Aboulaich; Patricia C Chui; John M Asara; Jeffrey S Flier; Eleftheria Maratos-Flier
Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism.
Diabetes 2011;60(3):757-65.
2010: Nadege Briancon; David E McNay; Eleftheria Maratos-Flier; Jeffrey S Flier
Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance.
Diabetes 2010;59(12):3074-84.
2010: Ffolliott M Fisher; Patricia C Chui; Patrick J Antonellis; Holly A Bina; Alexei Kharitonenkov; Jeffrey S Flier; Eleftheria Maratos-Flier
Obesity is a fibroblast growth factor 21 (FGF21)-resistant state.
Diabetes 2010;59(11):2781-9.
2010: Jeffrey S Flier; Eleftheria Maratos-Flier
Lasker lauds leptin.
Cell metabolism 2010;12(4):317-20.
2010: Jeffrey S Flier; Eleftheria Maratos-Flier
Lasker lauds leptin.
Cell 2010;143(1):9-12.
2010: Andrew C Adams; Inna Astapova; Ffolliott M Fisher; Michael K Badman; Katherine E Kurgansky; Jeffrey S Flier; Anthony N Hollenberg; Eleftheria Maratos-Flier
Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.
The Journal of biological chemistry 2010;285(19):14078-82.
2010: Randolph M Nesse; Carl T Bergstrom; Peter T Ellison; Jeffrey S Flier; Peter Gluckman; Diddahally R Govindaraju; Dietrich Niethammer; Gilbert S Omenn; Robert L Perlman; Mark D Schwartz; Mark Thomas; Stephen C Stearns; David Valle
Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine.
Proceedings of the National Academy of Sciences of the United States of America 2010;107 Suppl 1():1800-7.
2009: Jeffrey S Flier; John J Mekalanos
Gut check: testing a role for the intestinal microbiome in human obesity.
Science translational medicine 2009;1(6):6ps7.
2009: Michael K Badman; Anja Koester; Jeffrey S Flier; Alexei Kharitonenkov; Eleftheria Maratos-Flier
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.
Endocrinology 2009;150(11):4931-40.
2009: Petra C Kienesberger; Daeho Lee; THOMAS CHACKO PULINILKUNNIL; Daniel S Brenner; Lingzhi Cai; Christoph Magnes; Harald C Koefeler; Ingo E Streith; Gerald N Rechberger; Guenter Haemmerle; Jeffrey S Flier; Rudolf Zechner; Young-Bum Kim; Erin E Kershaw
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling.
The Journal of biological chemistry 2009;284(44):30218-29.
2009: Jeffrey S Flier
Health care reform: without a correct diagnosis, there is no cure.
The Journal of clinical investigation 2009;119(10):2850-2.
2009: Ren Zhang; Eleftheria Maratos-Flier; Jeffrey S Flier
Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B.
Endocrinology 2009;150(7):3076-82.
2008: Ren Zhang; Harveen Dhillon; Huali Yin; Akihiko Yoshimura; Bradford B Lowell; Eleftheria Maratos-Flier; Jeffrey S Flier
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.
Endocrinology 2008;149(11):5654-61.
2008: Maria Koulmanda; Manoj Bhasin; Lauren Hoffman; Zhigang Fan; Andi Qipo; Hang Shi; Susan Bonner-Weir; Prabhakar Putheti; Nicolas Degauque; Towia Libermann; Hugh Auchincloss; Jeffrey S Flier; Terry B Strom
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16242-7.
2007: Erin E Kershaw; Michael Schupp; Hong-Ping Guan; Noah P Gardner; Mitchell Lazar; Jeffrey S Flier
PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1736-45.
2007: Maia V Kokoeva; Huali Yin; Jeffrey S Flier
Evidence for constitutive neural cell proliferation in the adult murine hypothalamus.
The Journal of comparative neurology 2007;505(2):209-20.
2007: Jeffrey S Flier; Eleftheria Maratos-Flier
What fuels fat.
Scientific American 2007;297(3):72-81.
2007: Karen E Inouye; Hang Shi; Jane K Howard; Christine H Daly; Graham M Lord; Barrett J Rollins; Jeffrey S Flier
Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.
Diabetes 2007;56(9):2242-50.
2007: Maria Koulmanda; Ejona Budo; Susan Bonner-Weir; Andi Qipo; Prabhakar Putheti; Nicolas Degauque; Hang Shi; Zhigang Fan; Jeffrey S Flier; Hugh Auchincloss; Xin Xiao Zheng; Terry B Strom
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13074-9.
2007: Michael K Badman; Pavlos Pissios; Adam R Kennedy; Georgios Koukos; Jeffrey S Flier; Eleftheria Maratos-Flier
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.
Cell metabolism 2007;5(6):426-37.
2007: Michael K Badman; Jeffrey S Flier
The adipocyte as an active participant in energy balance and metabolism.
Gastroenterology 2007;132(6):2103-15.
2007: Kevin J Cheung; Iphigenia Tzameli; Pavlos Pissios; Ilsa Rovira; Oksana Gavrilova; Toshio Ohtsubo; Zhu Chen; TOREN FINKEL; Jeffrey S Flier; Jeffrey M Friedman
Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.
Cell metabolism 2007;5(2):115-28.
2006: Hang Shi; Maia V Kokoeva; Karen Inouye; Iphigenia Tzameli; Huali Yin; Jeffrey S Flier
TLR4 links innate immunity and fatty acid-induced insulin resistance.
The Journal of clinical investigation 2006;116(11):3015-25.
2006: Jane K Howard; Jeffrey S Flier
Attenuation of leptin and insulin signaling by SOCS proteins.
Trends in endocrinology and metabolism: TEM 2006;17(9):365-71.
2006: Stephanie Fulton; Pavlos Pissios; Ramon Pinol Manchon; Linsey Stiles; Lauren Frank; Emmanuel N Pothos; Eleftheria Maratos-Flier; Jeffrey S Flier
Leptin regulation of the mesoaccumbens dopamine pathway.
Neuron 2006;51(6):811-22.
2006: Paul Kievit; Jane K Howard; Michael K Badman; Nina Balthasar; Roberto Coppari; Hiroyuki Mori; Charlotte E Lee; Joel K Elmquist; Akihiko Yoshimura; Jeffrey S Flier
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.
Cell metabolism 2006;4(2):123-32.
2006: Jeffrey S Flier
Neuroscience. Regulating energy balance: the substrate strikes back.
Science (New York, N.Y.) 2006;312(5775):861-4.
2006: Jeffrey M Blumberg; Iphigenia Tzameli; Inna Astapova; Francis S Lam; Jeffrey S Flier; Anthony N Hollenberg
Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells.
The Journal of biological chemistry 2006;281(16):11205-13.
2006: Hang Shi; Belinda Cave; Karen Inouye; Christian Bjørbaek; Jeffrey S Flier
Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance.
Diabetes 2006;55(3):699-707.
2006: Jeffrey S Flier
AgRP in energy balance: Will the real AgRP please stand up?
Cell metabolism 2006;3(2):83-5.
2006: Erin E Kershaw; Jonathan K Hamm; Linda A W Verhagen; Odile D Peroni; Masa Katic; Jeffrey S Flier
Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin.
Diabetes 2006;55(1):148-57.
2005: Maia V Kokoeva; Huali Yin; Jeffrey S Flier
Neurogenesis in the hypothalamus of adult mice: potential role in energy balance.
Science (New York, N.Y.) 2005;310(5748):679-83.
2005: Erin E Kershaw; Nicholas M Morton; Harveen Dhillon; Lynne Ramage; Jonathan R Seckl; Jeffrey S Flier
Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity.
Diabetes 2005;54(4):1023-31.
2005: Michael K Badman; Jeffrey S Flier
The gut and energy balance: visceral allies in the obesity wars.
Science (New York, N.Y.) 2005;307(5717):1909-14.
2004: Jeffrey S Flier; Joel K Elmquist
A good night's sleep: future antidote to the obesity epidemic?
Annals of internal medicine 2004;141(11):885-6.
2004: Heike Münzberg; Jeffrey S Flier; Christian Bjørbaek
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.
Endocrinology 2004;145(11):4880-9.
2004: Iphigenia Tzameli; Hui Fang; Mario Ollero; Hang Shi; Jonathan K Hamm; Paul Kievit; Anthony N Hollenberg; Jeffrey S Flier
Regulated production of a peroxisome proliferator-activated receptor-gamma ligand during an early phase of adipocyte differentiation in 3T3-L1 adipocytes.
The Journal of biological chemistry 2004;279(34):36093-102.
2004: Hang Shi; Iphigenia Tzameli; Christian Bjørbaek; Jeffrey S Flier
Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.
The Journal of biological chemistry 2004;279(33):34733-40.
2004: Jane K Howard; Belinda J Cave; Laura J Oksanen; Iphigenia Tzameli; Christian Bjørbaek; Jeffrey S Flier
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.
Nature medicine 2004;10(7):734-8.
2004: Erin E Kershaw; Jeffrey S Flier
Adipose tissue as an endocrine organ.
The Journal of clinical endocrinology and metabolism 2004;89(6):2548-56.
2004: Joel K Elmquist; Jeffrey S Flier
Neuroscience. The fat-brain axis enters a new dimension.
Science (New York, N.Y.) 2004;304(5667):63-4.
2004: Nicholas M Morton; Janice M Paterson; Hiroaki Masuzaki; Megan C Holmes; Bart Staels; Catherine Fievet; Brian R Walker; Jeffrey S Flier; John J Mullins; Jonathan R Seckl
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Diabetes 2004;53(4):931-8.
2004: Joseph F Kelly; Carol F Elias; Charlotte E Lee; Rexford S Ahima; Randy J Seeley; Christian Bjørbaek; Takakazu Oka; Clifford B Saper; Jeffrey S Flier; Joel K Elmquist
Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain.
Diabetes 2004;53(4):911-20.
2004: Jeffrey S Flier
Obesity wars: molecular progress confronts an expanding epidemic.
Cell 2004;116(2):337-50.
2003: Hiroaki Masuzaki; Jeffrey S Flier
Tissue-specific glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1)--a promising drug target for the treatment of metabolic syndrome.
Current drug targets. Immune, endocrine and metabolic disorders 2003;3(4):255-62.
2003: Gabriella Segal-Lieberman; Richard L Bradley; Efi Kokkotou; Michael Carlson; Daniel Trombly; Xiaomei Wang; Sarah Bates; Martin G Myers Jr; Jeffrey S Flier; Eleftheria Maratos-Flier
Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):10085-90.
2003: Hiroaki Masuzaki; Hiroshi Yamamoto; Christopher J Kenyon; Joel K Elmquist; Nicholas M Morton; Janice M Paterson; Hiroshi Shinyama; Matthew G F Sharp; Stewart Fleming; John J Mullins; Jonathan R Seckl; Jeffrey S Flier
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.
The Journal of clinical investigation 2003;112(1):83-90.
2003: Karim El-Haschimi; Scott D Dufresne; Michael F Hirshman; Jeffrey S Flier; Laurie J Goodyear; Christian Bjørbaek
Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.
Diabetes 2003;52(6):1340-6.
2003: Hiroshi Shinyama; Hiroaki Masuzaki; Hui Fang; Jeffrey S Flier
Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.
Endocrinology 2003;144(4):1301-14.
2002: Jeffrey S Flier
Physiology: is brain sympathetic to bone?
Nature 2002;420(6916):619, 621-22.
2002: Jeffrey S Flier; Eleftheria Maratos-Flier
The stomach speaks--ghrelin and weight regulation.
The New England journal of medicine 2002;346(21):1662-3.
2002: Dominique D Pierroz; Mary Ziotopoulou; Linda Ungsunan; Stergios J Moschos; Jeffrey S Flier; Christos S Mantzoros
Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity.
Diabetes 2002;51(5):1337-45.
2002: Ciaran Sewter; Dirk Berger; Robert V Considine; Gema Medina; Justin J Rochford; Theodore P Ciaraldi; Robert Henry; Lynis Dohm; Jeffrey S Flier; Stephen O'Rahilly; Antonio Vidal-Puig
Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha.
Diabetes 2002;51(4):1035-41.
2002: Stanley M Hileman; Dominique D Pierroz; Hiroaki Masuzaki; Christian Bjørbaek; Karim El-Haschimi; William A Banks; Jeffrey S Flier
Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity.
Endocrinology 2002;143(3):775-83.
2001: Hiroaki Masuzaki; J Paterson; Hiroshi Shinyama; Nicholas M Morton; John J Mullins; Jonathan R Seckl; Jeffrey S Flier
A transgenic model of visceral obesity and the metabolic syndrome.
Science (New York, N.Y.) 2001;294(5549):2166-70.
2001: Christian Bjørbaek; R M Buchholz; SM Davis; Sarah H Bates; Dominique D Pierroz; H Gu; Benjamin G Neel; Martin G Myers Jr; Jeffrey S Flier
Divergent roles of SHP-2 in ERK activation by leptin receptors.
The Journal of biological chemistry 2001;276(7):4747-55.
2001: DS Ludwig; Nicholas A Tritos; Jason W Mastaitis; R Kulkarni; Efi Kokkotou; Joel K Elmquist; Bradford B Lowell; Jeffrey S Flier; Eleftheria Maratos-Flier
Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance.
The Journal of clinical investigation 2001;107(3):379-86.
2001: M Harris; Carl J Aschkenasi; CF Elias; A Chandrankunnel; Eduardo A Nillni; C Bjøorbaek; Joel K Elmquist; Jeffrey S Flier; Anthony N Hollenberg
Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling.
The Journal of clinical investigation 2001;107(1):111-20.
2000: C Bjorbak; Hugh J Lavery; Sarah H Bates; R K Olson; SM Davis; Jeffrey S Flier; Martin G Myers Jr
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.
The Journal of biological chemistry 2000;275(51):40649-57.
2000: Mary Ziotopoulou; Christos S Mantzoros; Stanley M Hileman; Jeffrey S Flier
Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice.
American journal of physiology. Endocrinology and metabolism 2000;279(4):E838-45.
2000: Rexford S Ahima; Jeffrey S Flier
Adipose tissue as an endocrine organ.
Trends in endocrinology and metabolism: TEM 2000;11(8):327-32.
2000: Barbara B Kahn; Jeffrey S Flier
Obesity and insulin resistance.
The Journal of clinical investigation 2000;106(4):473-81.
2000: Rexford S Ahima; C B Saper; Jeffrey S Flier; Joel K Elmquist
Leptin regulation of neuroendocrine systems.
Frontiers in neuroendocrinology 2000;21(3):263-307.
2000: Y B Kim; S Uotani; D D Pierroz; Jeffrey S Flier; Barbara B Kahn
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin.
Endocrinology 2000;141(7):2328-39.
2000: Karim El-Haschimi; Dominique D Pierroz; Stanley M Hileman; Christian Bjørbaek; Jeffrey S Flier
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity.
The Journal of clinical investigation 2000;105(12):1827-32.
2000: Stanley M Hileman; J Tornøe; Jeffrey S Flier; Christian Bjørbaek
Transcellular transport of leptin by the short leptin receptor isoform ObRa in Madin-Darby Canine Kidney cells.
Endocrinology 2000;141(6):1955-61.
2000: Jeffrey S Flier; M Harris; Anthony N Hollenberg
Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring.
The Journal of clinical investigation 2000;105(7):859-61.
2000: Stanley M Hileman; Dominique D Pierroz; Jeffrey S Flier
Leptin, nutrition, and reproduction: timing is everything.
The Journal of clinical endocrinology and metabolism 2000;85(2):804-7.
1999: Rexford S Ahima; J Kelly; Joel K Elmquist; Jeffrey S Flier
Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia.
Endocrinology 1999;140(11):4923-31.
1999: Christian Bjørbaek; Karim El-Haschimi; J Daniel Frantz; Jeffrey S Flier
The role of SOCS-3 in leptin signaling and leptin resistance.
The Journal of biological chemistry 1999;274(42):30059-65.
1999: CF Elias; Carl J Aschkenasi; C Lee; J Kelly; Rexford S Ahima; C Bjorbaek; Jeffrey S Flier; Clifford B Saper; Joel K Elmquist
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.
Neuron 1999;23(4):775-86.
1999: Rexford S Ahima; C Bjorbaek; Suzette Y Osei; Jeffrey S Flier
Regulation of neuronal and glial proteins by leptin: implications for brain development.
Endocrinology 1999;140(6):2755-62.
1999: Christian Bjørbaek; Joel K Elmquist; Karim El-Haschimi; J Kelly; Rexford S Ahima; Stanley M Hileman; Jeffrey S Flier
Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor.
Endocrinology 1999;140(5):2035-43.
1999: S Uotani; Christian Bjørbaek; J Tornøe; Jeffrey S Flier
Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.
Diabetes 1999;48(2):279-86.
1998: M Shimada; Nicholas A Tritos; Bradford B Lowell; Jeffrey S Flier; Eleftheria Maratos-Flier
Mice lacking melanin-concentrating hormone are hypophagic and lean.
Nature 1998;396(6712):670-4.
1998: Nicholas A Tritos; Joel K Elmquist; Jason W Mastaitis; Jeffrey S Flier; Eleftheria Maratos-Flier
Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice.
Endocrinology 1998;139(11):4634-41.
1998: Joel K Elmquist; Eleftheria Maratos-Flier; C B Saper; Jeffrey S Flier
Unraveling the central nervous system pathways underlying responses to leptin.
Nature neuroscience 1998;1(6):445-50.
1998: B A da Silva; Christian Bjørbaek; S Uotani; Jeffrey S Flier
Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat.
Endocrinology 1998;139(9):3681-90.
1998: Gabor Legradi; C H Emerson; Rexford S Ahima; W M Rand; Jeffrey S Flier; Ronald M Lechan
Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus.
Neuroendocrinology 1998;68(2):89-97.
1998: Christian Bjørbaek; Joel K Elmquist; P Michl; Rexford S Ahima; AM van Bueren; Anthony L McCall; Jeffrey S Flier
Expression of leptin receptor isoforms in rat brain microvessels.
Endocrinology 1998;139(8):3485-91.
1998: Joel K Elmquist; Christian Bjørbaek; Rexford S Ahima; Jeffrey S Flier; Clifford B Saper
Distributions of leptin receptor mRNA isoforms in the rat brain.
The Journal of comparative neurology 1998;395(4):535-47.
1998: Christos S Mantzoros; A D Liolios; Nicholas A Tritos; V G Kaklamani; Dimitrios Doulgerakis; IOANNIS GRIVEAS; A C Moses; Jeffrey S Flier
Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men.
Obesity research 1998;6(3):179-86.
1998: Jeffrey S Flier
Clinical review 94: What's in a name? In search of leptin's physiologic role.
The Journal of clinical endocrinology and metabolism 1998;83(5):1407-13.
1998: DS Ludwig; K G Mountjoy; Jeffrey B Tatro; J A Gillette; RC Frederich; Jeffrey S Flier; Eleftheria Maratos-Flier
Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus.
The American journal of physiology 1998;274(4 Pt 1):E627-33.
1998: Christian Bjørbaek; Joel K Elmquist; J Daniel Frantz; Steven E Shoelson; Jeffrey S Flier
Identification of SOCS-3 as a potential mediator of central leptin resistance.
Molecular cell 1998;1(4):619-25.
1998: Rexford S Ahima; D Prabakaran; Jeffrey S Flier
Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.
The Journal of clinical investigation 1998;101(5):1020-7.
1998: Christos S Mantzoros; RC Frederich; D Qu; Bradford B Lowell; Eleftheria Maratos-Flier; Jeffrey S Flier
Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations.
Diabetes 1998;47(2):230-8.
1998: Joel K Elmquist; Rexford S Ahima; C F Elias; Jeffrey S Flier; Clifford B Saper
Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):741-6.
1997: Christian Bjørbaek; S Uotani; B da Silva; Jeffrey S Flier
Divergent signaling capacities of the long and short isoforms of the leptin receptor.
The Journal of biological chemistry 1997;272(51):32686-95.
1997: Gemma Solanes; Antonio Vidal-Puig; D Grujic; Jeffrey S Flier; Bradford B Lowell
The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts.
The Journal of biological chemistry 1997;272(41):25433-6.
1997: Christos S Mantzoros; S Moschos; I Avramopoulos; V Kaklamani; A Liolios; Dimitrios Doulgerakis; IOANNIS GRIVEAS; N Katsilambros; Jeffrey S Flier
Leptin concentrations in relation to body mass index and the tumor necrosis factor-alpha system in humans.
The Journal of clinical endocrinology and metabolism 1997;82(10):3408-13.
1997: Christos S Mantzoros; Anastasia A Varvarigou; V G Kaklamani; Nicholas G Beratis; Jeffrey S Flier
Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns.
The Journal of clinical endocrinology and metabolism 1997;82(9):2856-61.
1997: A Werman; Anthony N Hollenberg; Gemma Solanes; C Bjorbaek; Antonio Vidal-Puig; Jeffrey S Flier
Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin.
The Journal of biological chemistry 1997;272(32):20230-5.
1997: Antonio Vidal-Puig; Gemma Solanes; D Grujic; Jeffrey S Flier; Bradford B Lowell
UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.
Biochemical and biophysical research communications 1997;235(1):79-82.
1997: Christos S Mantzoros; Jeffrey S Flier; M D Lesem; Timothy D Brewerton; David C Jimerson
Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain.
The Journal of clinical endocrinology and metabolism 1997;82(6):1845-51.
1997: Christos S Mantzoros; A Dunaif; Jeffrey S Flier
Leptin concentrations in the polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 1997;82(6):1687-91.
1997: Antonio Vidal-Puig; R V Considine; M Jimenez-Liñan; A Werman; Walter J Pories; JF Caro; Jeffrey S Flier
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.
The Journal of clinical investigation 1997;99(10):2416-22.
1997: Jeffrey S Flier
Leptin expression and action: new experimental paradigms.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4242-5.
1997: Christos S Mantzoros; Jeffrey S Flier; A D Rogol
A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty.
The Journal of clinical endocrinology and metabolism 1997;82(4):1066-70.
1997: Rexford S Ahima; J Dushay; S N Flier; D Prabakaran; Jeffrey S Flier
Leptin accelerates the onset of puberty in normal female mice.
The Journal of clinical investigation 1997;99(3):391-5.
1997: Joel K Elmquist; Rexford S Ahima; Eleftheria Maratos-Flier; Jeffrey S Flier; C B Saper
Leptin activates neurons in ventrobasal hypothalamus and brainstem.
Endocrinology 1997;138(2):839-42.
1997: Saverio Cinti; RC Frederich; Maria Cristina Zingaretti; Rita De Matteis; Jeffrey S Flier; Bradford B Lowell
Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue.
Endocrinology 1997;138(2):797-804.
1997: pasha sarraf; RC Frederich; Ewa M Turner; G Ma; N T Jaskowiak; Dennis Rivet; Jeffrey S Flier; B B Lowell; D L Fraker; H Richard Alexander
Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia.
The Journal of experimental medicine 1997;185(1):171-5.
1997: Bradford B Lowell; Jeffrey S Flier
Brown adipose tissue, beta 3-adrenergic receptors, and obesity.
Annual review of medicine 1997;48():307-16.
1996: Karen L Houseknecht; C S Mantzoros; Regina Kuliawat; E Hadro; Jeffrey S Flier; Barbara B Kahn
Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity.
Diabetes 1996;45(11):1638-43.
1996: Rexford S Ahima; D Prabakaran; C Mantzoros; D Qu; Bradford B Lowell; Eleftheria Maratos-Flier; Jeffrey S Flier
Role of leptin in the neuroendocrine response to fasting.
Nature 1996;382(6588):250-2.
1996: C S Mantzoros; D Qu; RC Frederich; VS Susulic; Bradford B Lowell; Eleftheria Maratos-Flier; Jeffrey S Flier
Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice.
Diabetes 1996;45(7):909-14.
1996: Antonio Vidal-Puig; M Jimenez-Liñan; Bradford B Lowell; A Hamann; E Hu; B Spiegelman; Jeffrey S Flier; D E Moller
Regulation of PPAR gamma gene expression by nutrition and obesity in rodents.
The Journal of clinical investigation 1996;97(11):2553-61.
1996: D E Moller; P Y Chang; BB Yaspelkis; Jeffrey S Flier; H Wallberg-Henriksson; John L Ivy
Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia.
Endocrinology 1996;137(6):2397-405.
1996: Karen L Houseknecht; A X Zhu; Luigi Gnudi; A Hamann; Juleen R Zierath; E Tozzo; Jeffrey S Flier; Barbara B Kahn
Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin.
The Journal of biological chemistry 1996;271(19):11347-55.
1996: D S Ludwig; Antonio Vidal-Puig; Richard M O'Brien; Richard L Printz; D K Granner; D E Moller; Jeffrey S Flier
Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1996;81(2):503-6.
1996: R A Gabbay; Calum Sutherland; Luigi Gnudi; Barbara B Kahn; R M O'Brien; Daryl K Granner; Jeffrey S Flier
Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway.
The Journal of biological chemistry 1996;271(4):1890-7.
1996: A Hamann; Jeffrey S Flier; Bradford B Lowell
Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia.
Endocrinology 1996;137(1):21-9.
1995: VS Susulic; RC Frederich; J Lawitts; E Tozzo; Barbara B Kahn; Mary-Ellen Harper; Jean Himms-Hagen; Jeffrey S Flier; Bradford B Lowell
Targeted disruption of the beta 3-adrenergic receptor gene.
The Journal of biological chemistry 1995;270(49):29483-92.
1995: RC Frederich; A Hamann; S Anderson; B Löllmann; Bradford B Lowell; Jeffrey S Flier
Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action.
Nature medicine 1995;1(12):1311-4.
1995: Andreas Hamann; H Benecke; Y Le Marchand-Brustel; VS Susulic; Bradford B Lowell; Jeffrey S Flier
Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat.
Diabetes 1995;44(11):1266-73.
1995: RC Frederich; B Löllmann; A Hamann; A Napolitano-Rosen; Barbara B Kahn; Bradford B Lowell; Jeffrey S Flier
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.
The Journal of clinical investigation 1995;96(3):1658-63.
1995: A Hamann; C Mantzoros; Antonio Vidal-Puig; Jeffrey S Flier
Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM).
Biochemical and biophysical research communications 1995;211(3):833-9.
1995: Jeffrey S Flier
The adipocyte: storage depot or node on the energy information superhighway?
Cell 1995;80(1):15-8.
1995: Christos S Mantzoros; Jeffrey S Flier
Insulin resistance: the clinical spectrum.
Advances in endocrinology and metabolism 1995;6():193-232.
1994: D E Moller; O Cohen; Y Yamaguchi; R Assiz; FLORIN GRIGORESCU; A Eberle; L A Morrow; Alan C Moses; Jeffrey S Flier
Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance.
Diabetes 1994;43(2):247-55.
1993: Bradford B Lowell; V S-Susulic; A Hamann; J A Lawitts; J Himms-Hagen; Bert Boyer; Leslie P Kozak; Jeffrey S Flier
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue.
Nature 1993;366(6457):740-2.
1993: Jeffrey S Flier; D E Moller; Alan C Moses; S O'Rahilly; RL Chaiken; FLORIN GRIGORESCU; Dariush Elahi; Barbara B Kahn; J E Weinreb; R Eastman
Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.
The Journal of clinical endocrinology and metabolism 1993;76(6):1533-41.
1993: Y Yamaguchi; Jeffrey S Flier; H Benecke; B J Ransil; D E Moller
Ligand-binding properties of the two isoforms of the human insulin receptor.
Endocrinology 1993;132(3):1132-8.
1993: H Benecke; Jeffrey S Flier; N Rosenthal; K Siddle; Harald H Klein; D E Moller
Muscle-specific expression of human insulin receptor in transgenic mice.
Diabetes 1993;42(1):206-12.
1992: Jeffrey S Flier
Lilly Lecture: syndromes of insulin resistance. From patient to gene and back again.
Diabetes 1992;41(9):1207-19.
1992: H Benecke; Jeffrey S Flier; D E Moller
Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues.
The Journal of clinical investigation 1992;89(6):2066-70.
1992: R T White; D Damm; N Hancock; B S Rosen; Bradford B Lowell; P Usher; Jeffrey S Flier; Bruce M Spiegelman
Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.
The Journal of biological chemistry 1992;267(13):9210-3.
1992: RC Frederich; Barbara B Kahn; M J Peach; Jeffrey S Flier
Tissue-specific nutritional regulation of angiotensinogen in adipose tissue.
Hypertension 1992;19(4):339-44.
1992: Stephan Matthaei; Andreas Hamann; Harald H Klein; H Benecke; G Kreymann; Jeffrey S Flier; Heiner Greten
Evidence that metformin increases insulin-stimulated glucose transport by potentiating insulin-induced translocation of glucose transporters from an intracellular pool to the cell surface in rat adipocytes.
Hormone and metabolic research. Supplement series 1992;26():34-41.
1991: W H Choi; S O'Rahilly; John B Buse; A Rees; R Morgan; Jeffrey S Flier; D E Moller
Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects.
Diabetes 1991;40(12):1712-8.
1991: Y Yamaguchi; Jeffrey S Flier; A Yokota; H Benecke; Jonathan M Backer; D E Moller
Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells.
Endocrinology 1991;129(4):2058-66.
1991: Stephan Matthaei; Andreas Hamann; Harald H Klein; H Benecke; G Kreymann; Jeffrey S Flier; Heiner Greten
Association of Metformin's effect to increase insulin-stimulated glucose transport with potentiation of insulin-induced translocation of glucose transporters from intracellular pool to plasma membrane in rat adipocytes.
Diabetes 1991;40(7):850-7.
1991: D E Moller; H Benecke; Jeffrey S Flier
Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant.
The Journal of biological chemistry 1991;266(17):10995-1001.
1991: S O'Rahilly; W H Choi; P Patel; R C Turner; Jeffrey S Flier; D E Moller
Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms.
Diabetes 1991;40(6):777-82.
1991: A Napolitano; Bradford B Lowell; Jeffrey S Flier
Alterations in sympathetic nervous system activity do not regulate adipsin gene expression in mice.
International journal of obesity 1991;15(3):227-35.
1990: Bradford B Lowell; Jeffrey S Flier
Differentiation dependent biphasic regulation of adipsin gene expression by insulin and insulin-like growth factor-1 in 3T3-F442A adipocytes.
Endocrinology 1990;127(6):2898-906.
1990: K G Mountjoy; Jeffrey S Flier
Vanadate regulates glucose transporter (Glut-1) expression in NIH3T3 mouse fibroblasts.
Endocrinology 1990;127(4):2025-34.
1990: D E Moller; A Yokota; M F White; A G Pazianos; Jeffrey S Flier
A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.
The Journal of biological chemistry 1990;265(25):14979-85.
1990: Bradford B Lowell; A Napolitano; P Usher; A G Dulloo; B S Rosen; Bruce M Spiegelman; Jeffrey S Flier
Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
Endocrinology 1990;126(3):1514-20.
1989: K G Mountjoy; G M Housey; Jeffrey S Flier
Overproduction of the beta 1 form of protein kinase C enhances phorbol ester induction of glucose transporter mRNA.
Molecular endocrinology (Baltimore, Md.) 1989;3(12):2018-27.
1989: D E Moller; A Yokota; Jeffrey S Flier
Normal insulin-receptor cDNA sequence in Pima Indians with NIDDM.
Diabetes 1989;38(11):1496-500.
1989: P T Matsouka; Jeffrey S Flier
Relationship between c-src tyrosine kinase activity and the control of glucose transporter gene expression.
Molecular endocrinology (Baltimore, Md.) 1989;3(11):1845-51.
1989: KL Minaker; Jeffrey S Flier; L Landsberg; J B Young; Richard T Moxley; W J Kingston; Graydon S Meneilly; J W Rowe
Phenytoin-induced improvement in muscle cramping and insulin action in three patients with the syndrome of insulin resistance, acanthosis nigricans, and acral hypertrophy.
Archives of neurology 1989;46(9):981-5.
1989: D E Moller; A Yokota; J F Caro; Jeffrey S Flier
Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man.
Molecular endocrinology (Baltimore, Md.) 1989;3(8):1263-9.
1989: Alan C Moses; P Usher; N Ikari; P P King; Donatella Tramontano; Jeffrey S Flier
Multiple factors influence insulin-like growth factor-I binding to human skin fibroblasts.
Endocrinology 1989;125(2):867-75.
1989: Bruce M Spiegelman; Bradford B Lowell; A Napolitano; P Dubuc; D Barton; U Francke; D L Groves; K S Cook; Jeffrey S Flier
Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice.
The Journal of biological chemistry 1989;264(3):1811-5.
1989: Barbara B Kahn; S W Cushman; Jeffrey S Flier
Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number.
The Journal of clinical investigation 1989;83(1):199-204.
1989: Jeffrey S Flier; Bradford B Lowell; A Napolitano; P Usher; B Rosen; K S Cook; Bruce M Spiegelman
Adipsin: regulation and dysregulation in obesity and other metabolic states.
Recent progress in hormone research 1989;45():567-80; discussion 580-1.
1988: Barrett J Rollins; E D Morrison; P Usher; Jeffrey S Flier
Platelet-derived growth factor regulates glucose transporter expression.
The Journal of biological chemistry 1988;263(32):16523-6.
1988: D E Moller; Jeffrey S Flier
Problems of insulin resistance.
Hospital practice (Office ed.) 1988;23(10A):83-4, 86, 89 passim.
1988: N Ikari; H Yoshino; Alan C Moses; Jeffrey S Flier
Evidence that receptor aggregation may play a role in transmembrane signaling through the insulin-like growth factor-I receptor.
Molecular endocrinology (Baltimore, Md.) 1988;2(9):831-7.
1988: L Porestsky; L Levesque; M M Seibel; D Smith; A Pazianos; J Hurd; T Aretz; Jeffrey S Flier
Characteristics of in vitro steroidogenesis in a woman with hyperandrogenism, a granulosa cell tumor and polycystic ovary disease. A case report.
The Journal of reproductive medicine 1988;33(4):377-81.
1987: Jeffrey S Flier; K S Cook; P Usher; Bruce M Spiegelman
Severely impaired adipsin expression in genetic and acquired obesity.
Science (New York, N.Y.) 1987;237(4813):405-8.
1987: K S Cook; H Y Min; D Johnson; R J Chaplinsky; Jeffrey S Flier; C R Hunt; Bruce M Spiegelman
Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve.
Science (New York, N.Y.) 1987;237(4813):402-5.
1987: G S Gates; S Bayer; M Seibel; Leonid Poretsky; Jeffrey S Flier; Alan C Moses
Characterization of insulin-like growth factor binding to human granulosa cells obtained during in vitro fertilization.
Journal of receptor research 1987;7(6):885-902.
1986: RL Chaiken; Alan C Moses; P Usher; Jeffrey S Flier
Insulin stimulation of aminoisobutyric acid transport in human skin fibroblasts is mediated through both insulin and type I insulin-like growth factor receptors.
The Journal of clinical endocrinology and metabolism 1986;63(5):1181-5.
1986: Jeffrey S Flier; P Usher; Alan C Moses
Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(3):664-8.
1985: Leonid Poretsky; FLORIN GRIGORESCU; M Seibel; Alan C Moses; Jeffrey S Flier
Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary.
The Journal of clinical endocrinology and metabolism 1985;61(4):728-34.
1984: Leonid Poretsky; D Smith; M Seibel; A Pazianos; Alan C Moses; Jeffrey S Flier
Specific insulin binding sites in human ovary.
The Journal of clinical endocrinology and metabolism 1984;59(4):809-11.