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Alexander Florence

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Alexander T Florence
"Targeting" nanoparticles: the constraints of physical laws and physical barriers.
Alexander T Florence; Vincent H L Lee
Personalised medicines: more tailored drugs, more tailored delivery.
Hisham Al-Obaidi; Behrooz Nasseri; Alexander T Florence
Dynamics of microparticles inside lipid vesicles: movement in confined spaces.

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All Publications

2012: Alexander T Florence
"Targeting" nanoparticles: the constraints of physical laws and physical barriers.
Journal of controlled release : official journal of the Controlled Release Society 2012;164(2):115-24.
2011: Alexander T Florence; Vincent H L Lee
Personalised medicines: more tailored drugs, more tailored delivery.
International journal of pharmaceutics 2011;415(1-2):29-33.
2010: Hisham Al-Obaidi; Behrooz Nasseri; Alexander T Florence
Dynamics of microparticles inside lipid vesicles: movement in confined spaces.
Journal of drug targeting 2010;18(10):821-30.
2010: Pakatip Ruenraroengsak; Alexander T Florence
Biphasic interactions between a cationic dendrimer and actin.
Journal of drug targeting 2010;18(10):803-11.
2010: Khuloud T Al-Jamal; Wafa' T Al-Jamal; Simon Akerman; Jennifer E Podesta; Açelya Yilmazer; John A Turton; Alberto Bianco; Neil Vargesson; Chryso Kanthou; Alexander T Florence; Gillian M Tozer; Kostas Kostarelos
Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):3966-71.
2010: Pakatip Ruenraroengsak; Janice M Cook; Alexander T Florence
Nanosystem drug targeting: Facing up to complex realities.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(3):265-76.
2008: H Mizuuchi; V Jaitely; Sudaxshina Murdan; Alexander T Florence
Room temperature ionic liquids and their mixtures: potential pharmaceutical solvents.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;33(4-5):326-31.
2008: Vikas Jaitely; Aysegül Karatas; Alexander T Florence
Water-immiscible room temperature ionic liquids (RTILs) as drug reservoirs for controlled release.
International journal of pharmaceutics 2008;354(1-2):168-73.
2007: Suzie Ribeiro; Sjoerd Rijpkema; Zarmina Durrani; Alexander T Florence
PLGA-dendron nanoparticles enhance immunogenicity but not lethal antibody production of a DNA vaccine against anthrax in mice.
International journal of pharmaceutics 2007;331(2):228-32.
2007: Orawan Suitthimeathegorn; John A Turton; Hiroshi Mizuuchi; Alexander T Florence
Intramuscular absorption and biodistribution of dexamethasone from non-aqueous emulsions in the rat.
International journal of pharmaceutics 2007;331(2):204-10.
2007: Pakatip Ruenraroengsak; Khuloud T Al-Jamal; Nicholas Hartell; Kevin Braeckmans; Stefaan C De Smedt; Alexander T Florence
Cell uptake, cytoplasmic diffusion and nuclear access of a 6.5 nm diameter dendrimer.
International journal of pharmaceutics 2007;331(2):215-9.
2006: Khuloud T Al-Jamal; Pakatip Ruenraroengsak; Nicholas Hartell; Alexander T Florence
An intrinsically fluorescent dendrimer as a nanoprobe of cell transport.
Journal of drug targeting 2006;14(6):405-12.
2006: Henry K Bayele; Chandrasekaran Ramaswamy; Andrew F Wilderspin; Kaila Surjit Srai; Istvan Toth; Alexander T Florence
Protein transduction by lipidic peptide dendrimers.
Journal of pharmaceutical sciences 2006;95(6):1227-37.
2005: Khuloud T Al-Jamal; Chandrasekaran Ramaswamy; Alexander T Florence
Supramolecular structures from dendrons and dendrimers.
Advanced drug delivery reviews 2005;57(15):2238-70.
2005: Behrooz Nasseri; Alexander T Florence
The relative flow of the walls of phospholipid tether bilayers.
International journal of pharmaceutics 2005;298(2):372-7.
2005: Suzie Ribeiro; Nasir Hussain; Alexander T Florence
Release of DNA from dendriplexes encapsulated in PLGA nanoparticles.
International journal of pharmaceutics 2005;298(2):354-60.
2005: Orawan Suitthimeathegorn; Vikas Jaitely; Alexander T Florence
Novel anhydrous emulsions: formulation as controlled release vehicles.
International journal of pharmaceutics 2005;298(2):367-71.
2005: Pakatip Ruenraroengsak; Alexander T Florence
The diffusion of latex nanospheres and the effective (microscopic) viscosity of HPMC gels.
International journal of pharmaceutics 2005;298(2):361-6.
2005: Baljit Singh; Alexander T Florence
Hydrophobic dendrimer-derived nanoparticles.
International journal of pharmaceutics 2005;298(2):348-53.
2005: Henry K Bayele; Thiagarajan Sakthivel; Martin O'Donell; K John Pasi; Andrew F Wilderspin; Christine A Lee; Istvan Toth; Alexander T Florence
Versatile peptide dendrimers for nucleic acid delivery.
Journal of pharmaceutical sciences 2005;94(2):446-57.
2005: Khuloud T Al-Jamal; Thiagarajan Sakthivel; Alexander T Florence
Dendrisomes: vesicular structures derived from a cationic lipidic dendron.
Journal of pharmaceutical sciences 2005;94(1):102-13.
2005: Mire Zloh; Chandrasekaran Ramaswamy; Thiagarajan Sakthivel; Andrew F Wilderspin; Alexander T Florence
Investigation of the association and flexibility of cationic lipidic peptide dendrons by NMR spectroscopy.
Magnetic resonance in chemistry : MRC 2005;43(1):47-52.
2004: Alexander T Florence
Issues in oral nanoparticle drug carrier uptake and targeting.
Journal of drug targeting 2004;12(2):65-70.
2003: Baljit Singh; Nasir Hussain; Thiagarajan Sakthivel; Alexander T Florence
Effect of physiological media on the stability of surface-adsorbed DNA-dendron-gold nanoparticles.
The Journal of pharmacy and pharmacology 2003;55(12):1635-40.
2003: Behrooz Nasseri; Alexander T Florence
Microtubules formed by capillary extrusion and fusion of surfactant vesicles.
International journal of pharmaceutics 2003;266(1-2):91-8.
2003: Behrooz Nasseri; Alexander T Florence
A vesicular shuttle: transport of a vesicle within a flexible microtube.
Journal of controlled release : official journal of the Controlled Release Society 2003;92(3):233-40.
2003: Gaurang Purohit; Thiagarajan Sakthivel; Alexander T Florence
The interaction of cationic dendrons with albumin and their diffusion through cellulose membranes.
International journal of pharmaceutics 2003;254(1):37-41.
2003: Khuloud T Al-Jamal; Thiagarajan Sakthivel; Alexander T Florence
Dendrisomes: cationic lipidic dendron vesicular assemblies.
International journal of pharmaceutics 2003;254(1):33-6.
2003: Nasir Hussain; Baljit Singh; Thiagarajan Sakthivel; Alexander T Florence
Formulation and stability of surface-tethered DNA-gold-dendron nanoparticles.
International journal of pharmaceutics 2003;254(1):27-31.
2003: Thiagarajan Sakthivel; Alexander T Florence
Adsorption of amphipathic dendrons on polystyrene nanoparticles.
International journal of pharmaceutics 2003;254(1):23-6.
2003: Chandrasekaran Ramaswamy; Thiagarajan Sakthivel; Andrew F Wilderspin; Alexander T Florence
Dendriplexes and their characterisation.
International journal of pharmaceutics 2003;254(1):17-21.
2003: Behrooz Nasseri; Alexander T Florence
Some properties of extruded non-ionic surfactant micro-tubes.
International journal of pharmaceutics 2003;254(1):11-6.
2002: Malene Jensen; Pernille Birch Hansen; Sudaxshina Murdan; Sven Frokjaer; Alexander T Florence
Loading into and electro-stimulated release of peptides and proteins from chondroitin 4-sulphate hydrogels.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2002;15(2):139-48.
2001: Alexander T Florence; Nasir Hussain
Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas.
Advanced drug delivery reviews 2001;50 Suppl 1():S69-89.
2001: Nasir Hussain; V Jaitley; Alexander T Florence
Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics.
Advanced drug delivery reviews 2001;50(1-2):107-42.
2001: G Purohit; Thiagarajan Sakthivel; Alexander T Florence
Interaction of cationic partial dendrimers with charged and neutral liposomes.
International journal of pharmaceutics 2001;214(1-2):71-6.
2001: S Yanai; Thiagarajan Sakthivel; Alexander T Florence
Interfacial behaviour and micelle formation of novel amphiphilic sequential lipid-lysine oligomers.
International journal of pharmaceutics 2001;214(1-2):49-53.
2001: Thiagarajan Sakthivel; V Jaitely; N V Patel; Alexander T Florence
Non-aqueous emulsions: hydrocarbon-formamide systems.
International journal of pharmaceutics 2001;214(1-2):43-8.
2001: D Dimitrijevic; P S Whitton; MA Domin; Kevin J Welham; Alexander T Florence
Increased vigabatrin entry into the brain by polysorbate 80 and sodium caprate.
The Journal of pharmacy and pharmacology 2001;53(2):149-54.
2000: D S Shah; Thiagarajan Sakthivel; Istvan Toth; Alexander T Florence; Andrew F Wilderspin
DNA transfection and transfected cell viability using amphipathic asymmetric dendrimers.
International journal of pharmaceutics 2000;208(1-2):41-8.
2000: P Arunothayanun; M S Bernard; Duncan Q M Craig; Ijeoma F Uchegbu; Alexander T Florence
The effect of processing variables on the physical characteristics of non-ionic surfactant vesicles (niosomes) formed from a hexadecyl diglycerol ether.
International journal of pharmaceutics 2000;201(1):7-14.
2000: Alexander T Florence; Thiagarajan Sakthivel; Istvan Toth
Oral uptake and translocation of a polylysine dendrimer with a lipid surface.
Journal of controlled release : official journal of the Controlled Release Society 2000;65(1-2):253-9.
2000: D Dimitrijevic; A J Shaw; Alexander T Florence
Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells.
The Journal of pharmacy and pharmacology 2000;52(2):157-62.
1999: P Arunothayanun; T Sooksawate; Alexander T Florence
Extrusion of niosomes from capillaries: approaches to a pulsed delivery device.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):391-7.
1999: Sudaxshina Murdan; Gregory Gregoriadis; Alexander T Florence
Sorbitan monostearate/polysorbate 20 organogels containing niosomes: a delivery vehicle for antigens?
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1999;8(3):177-86.
1999: P Arunothayanun; Ijeoma F Uchegbu; Duncan Q M Craig; John A Turton; Alexander T Florence
In vitro/in vivo characterisation of polyhedral niosomes.
International journal of pharmaceutics 1999;183(1):57-61.
1999: Thiagarajan Sakthivel; Istvan Toth; Alexander T Florence
Distribution of a lipidic 2.5 nm diameter dendrimer carrier after oral administration.
International journal of pharmaceutics 1999;183(1):51-5.
1999: Sudaxshina Murdan; Gregory Gregoriadis; Alexander T Florence
Inverse toroidal vesicles: precursors of tubules in sorbitan monostearate organogels.
International journal of pharmaceutics 1999;183(1):47-9.
1999: B Carreno-Gómez; J F Woodley; Alexander T Florence
Studies on the uptake of tomato lectin nanoparticles in everted gut sacs.
International journal of pharmaceutics 1999;183(1):7-11.
1999: J Ford; J Woolfe; Alexander T Florence
Nanospheres of cyclosporin A: poor oral absorption in dogs.
International journal of pharmaceutics 1999;183(1):3-6.
1999: P Arunothayanun; Ijeoma F Uchegbu; Alexander T Florence
Osmotic behaviour of polyhedral non-ionic surfactant vesicles (niosomes).
The Journal of pharmacy and pharmacology 1999;51(6):651-7.
1999: Sudaxshina Murdan; B van den Bergh; Gregory Gregoriadis; Alexander T Florence
Water-in-sorbitan monostearate organogels (water-in-oil gels).
Journal of pharmaceutical sciences 1999;88(6):615-9.
1999: Sudaxshina Murdan; Gregory Gregoriadis; Alexander T Florence
Novel sorbitan monostearate organogels.
Journal of pharmaceutical sciences 1999;88(6):608-14.
1999: Sudaxshina Murdan; Gregory Gregoriadis; Alexander T Florence
Interaction of a nonionic surfactant-based organogel with aqueous media.
International journal of pharmaceutics 1999;180(2):211-4.
1999: P Arunothayanun; John A Turton; Ijeoma F Uchegbu; Alexander T Florence
Preparation and in vitro/in vivo evaluation of luteinizing hormone releasing hormone (LHRH)-loaded polyhedral and spherical/tubular niosomes.
Journal of pharmaceutical sciences 1999;88(1):34-8.
1998: Thiagarajan Sakthivel; Istvan Toth; Alexander T Florence
Synthesis and physicochemical properties of lipophilic polyamide dendrimers.
Pharmaceutical research 1998;15(5):776-82.
1998: Nasir Hussain; Alexander T Florence
Utilizing bacterial mechanisms of epithelial cell entry: invasin-induced oral uptake of latex nanoparticles.
Pharmaceutical research 1998;15(1):153-6.
1997: D Dimitrijevic; C Lamandin; Ijeoma F Uchegbu; A J Shaw; Alexander T Florence
The effect of monomers and of micellar and vesicular forms of non-ionic surfactants (Solulan C24 and Solulan 16) on Caco-2 cell monolayers.
The Journal of pharmacy and pharmacology 1997;49(6):611-6.
1997: Ijeoma F Uchegbu; Andreas G Schätzlein; G Vanlerberghe; N Morgatini; Alexander T Florence
Polyhedral non-ionic surfactant vesicles.
The Journal of pharmacy and pharmacology 1997;49(6):606-10.
1997: Alexander T Florence
Peter Howard Elworthy (1933-1995): a biographical note.
The Journal of pharmacy and pharmacology 1997;49(6):579-86.
1997: Nasir Hussain; P U Jani; Alexander T Florence
Enhanced oral uptake of tomato lectin-conjugated nanoparticles in the rat.
Pharmaceutical research 1997;14(5):613-8.
1997: Alexander T Florence
The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual.
Pharmaceutical research 1997;14(3):259-66.
1996: P U Jani; T Nomura; F Yamashita; Yoshinobu Takakura; Alexander T Florence; M Hashida
Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats.
Journal of drug targeting 1996;4(2):87-93.
1996: Ijeoma F Uchegbu; J A Double; L R Kelland; John A Turton; Alexander T Florence
The activity of doxorubicin niosomes against an ovarian cancer cell line and three in vivo mouse tumour models.
Journal of drug targeting 1996;3(5):399-409.
1996: Ijeoma F Uchegbu; Alexander T Florence
Adverse drug events related to dosage forms and delivery systems.
Drug safety : an international journal of medical toxicology and drug experience 1996;14(1):39-67.
1995: Ijeoma F Uchegbu; J A Double; John A Turton; Alexander T Florence
Distribution, metabolism and tumoricidal activity of doxorubicin administered in sorbitan monostearate (Span 60) niosomes in the mouse.
Pharmaceutical research 1995;12(7):1019-24.
1995: Alexander T Florence; A M Hillery; Nasir Hussain; P U Jani
Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence.
Journal of drug targeting 1995;3(1):65-70.
1994: Ijeoma F Uchegbu; John A Turton; J A Double; Alexander T Florence
Drug distribution and a pulmonary adverse effect of intraperitoneally administered doxorubicin niosomes in the mouse.
Biopharmaceutics & drug disposition 1994;15(8):691-707.
1994: Alexander T Florence; P U Jani
Novel oral drug formulations. Their potential in modulating adverse effects.
Drug safety : an international journal of medical toxicology and drug experience 1994;10(3):233-66.
1994: A M Hillery; P U Jani; Alexander T Florence
Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60 nm polystyrene particles.
Journal of drug targeting 1994;2(2):151-6.
1991: Alexander T Florence; G W Halbert
Lipoproteins and microemulsions as carriers of therapeutic and chemical agents.
Targeted diagnosis and therapy 1991;5():141-74.
1990: P Jani; G W Halbert; J Langridge; Alexander T Florence
Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency.
The Journal of pharmacy and pharmacology 1990;42(12):821-6.
1989: P Jani; G W Halbert; J Langridge; Alexander T Florence
The uptake and translocation of latex nanospheres and microspheres after oral administration to rats.
The Journal of pharmacy and pharmacology 1989;41(12):809-12.
1989: J G Eley; G W Halbert; Alexander T Florence
Incorporation of dyes into low density lipoprotein in the presence of non-ionic surfactants.
The Journal of pharmacy and pharmacology 1989;41(12):858-60.
1989: I A Darwish; Alexander T Florence; A M Saleh
Effects of hydrotropic agents on the solubility, precipitation, and protein binding of etoposide.
Journal of pharmaceutical sciences 1989;78(7):577-81.
1989: N Willmott; Y Chen; J Goldberg; C Mcardle; Alexander T Florence
Biodegradation rate of embolized protein microspheres in lung, liver and kidney of rats.
The Journal of pharmacy and pharmacology 1989;41(7):433-8.
1989: J A Omotosho; T L Whateley; Alexander T Florence
Release of 5-fluorouracil from intramuscular w/o/w multiple emulsions.
Biopharmaceutics & drug disposition 1989;10(3):257-68.
1989: A M Saleh; Alexander T Florence; T L Whateley; L K el-Khordagui
The effect of hydrotropic agents on the heat coagulation of bovine serum albumin.
The Journal of pharmacy and pharmacology 1989;41(5):298-301.
1989: J A Omotosho; T L Whateley; Alexander T Florence
Methotrexate transport from the internal phase of multiple w/o/w emulsions.
Journal of microencapsulation 1989;6(2):183-92.
1989: G W Halbert; Alexander T Florence
Physiochemical characterization of methotrexate-bovine serum albumin conjugates.
The Journal of pharmacy and pharmacology 1989;41(4):222-6.
1989: J M Cook; Alexander T Florence; J Russell; T E Wheldon
Etoposide (VP-16) uptake by tumour spheroids and activity in the presence of Brij 30, formulation additives and sodium salicylate.
European journal of cancer & clinical oncology 1989;25(2):311-8.
1988: David J Kerr; A Rogerson; G J Morrison; Alexander T Florence; Stanley B Kaye
Antitumour activity and pharmacokinetics of niosome encapsulated adriamycin in monolayer, spheroid and xenograft.
British journal of cancer 1988;58(4):432-6.
1988: A Rogerson; Jeff Cummings; N Willmott; Alexander T Florence
The distribution of doxorubicin in mice following administration in niosomes.
The Journal of pharmacy and pharmacology 1988;40(5):337-42.
1987: Y Chen; N Willmott; J Anderson; Alexander T Florence
Comparison of albumin and casein microspheres as a carrier for doxorubicin.
The Journal of pharmacy and pharmacology 1987;39(12):978-85.
1987: G W Halbert; Alexander T Florence; J F Stuart
Characterization of in-vitro drug release and biological activity of methotrexate-bovine serum albumin conjugates.
The Journal of pharmacy and pharmacology 1987;39(11):871-6.
1987: A Rogerson; Jeff Cummings; Alexander T Florence
Adriamycin-loaded niosomes: drug entrapment, stability and release.
Journal of microencapsulation 1987;4(4):321-8.
1987: David J Kerr; T E Wheldon; J G Russell; H R Maurer; Alexander T Florence; G W Halbert; R. Ian Freshney; Stanley B Kaye
The effect of the non-ionic surfactant Brij 30 on the cytotoxicity of adriamycin in monolayer, spheroid and clonogenic culture systems.
European journal of cancer & clinical oncology 1987;23(9):1315-22.
1986: J A Omotosho; T L Whateley; T K Law; Alexander T Florence
The nature of the oil phase and the release of solutes from multiple (w/o/w) emulsions.
The Journal of pharmacy and pharmacology 1986;38(12):865-70.
1986: A Y Mendelow; A Forsyth; J W Feather; Alan J Baillie; Alexander T Florence
Skin reflectance measurements of patch test responses.
Contact dermatitis 1986;15(2):73-8.
1986: M N Azmin; Alexander T Florence; R M Handjani-Vila; J F Stuart; G Vanlerberghe; J S Whittaker
The effect of niosomes and polysorbate 80 on the metabolism and excretion of methotrexate in the mouse.
Journal of microencapsulation 1986;3(2):95-100.
1985: Alan J Baillie; Alexander T Florence; L R Hume; G T Muirhead; A Rogerson
The preparation and properties of niosomes--non-ionic surfactant vesicles.
The Journal of pharmacy and pharmacology 1985;37(12):863-8.
1985: Gillian M Eccleston; Alexander T Florence
Application of emulsion theory to complex and real systems.
International journal of cosmetic science 1985;7(5):195-212.
1985: N Willmott; Jeff Cummings; Alexander T Florence
In vitro release of adriamycin from drug-loaded albumin and haemoglobin microspheres.
Journal of microencapsulation 1985;2(4):293-304.
1985: A Y Mendelow; A Forsyth; Alexander T Florence; Alan J Baillie
Patch testing for nickel allergy. The influence of the vehicle on the response rate to topical nickel sulphate.
Contact dermatitis 1985;13(1):29-33.
1985: M N Azmin; Alexander T Florence; R M Handjani-Vila; J F Stuart; G Vanlerberghe; J S Whittaker
The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice.
The Journal of pharmacy and pharmacology 1985;37(4):237-42.
1985: G W Halbert; J F Stuart; Alexander T Florence
A low density lipoprotein-methotrexate covalent complex and its activity against L1210 cells in vitro.
Cancer chemotherapy and pharmacology 1985;15(3):223-7.
1985: M N Azmin; J F Stuart; Alexander T Florence
The distribution and elimination of methotrexate in mouse blood and brain after concurrent administration of polysorbate 80.
Cancer chemotherapy and pharmacology 1985;14(3):238-42.
1985: N Willmott; Jeff Cummings; J F Stuart; Alexander T Florence
Adriamycin-loaded albumin microspheres: preparation, in vivo distribution and release in the rat.
Biopharmaceutics & drug disposition 1985;6(1):91-104.
1982: M N Azmin; J F Stuart; K C Calman; Alexander T Florence
Effects of polysorbate 80 on the absorption and distribution of oral methotrexate (MTX) in mice.
Cancer chemotherapy and pharmacology 1982;9(3):161-4.