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Roderick Flower

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lucy norling; Jesmond Dalli; Roderick J Flower; Charles N Serhan; Mauro Perretti
Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.
Stefania Bena; Vincenzo Brancaleone; Mauro Perretti; Ji Ming Wang; Roderick J Flower
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
Samir S Ayoub; Christopher Bolton; Roderick J Flower; Gareth Pryce; Michael P Seed; David Baker
Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404.

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2012: lucy norling; Jesmond Dalli; Roderick J Flower; Charles N Serhan; Mauro Perretti
Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(8):1970-8.
2012: Stefania Bena; Vincenzo Brancaleone; Mauro Perretti; Ji Ming Wang; Roderick J Flower
Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.
The Journal of biological chemistry 2012;287(29):24690-7.
2011: Samir S Ayoub; Christopher Bolton; Roderick J Flower; Gareth Pryce; Michael P Seed; David Baker
Paracetamol-induced hypothermia is independent of cannabinoids and transient receptor potential vanilloid-1 and is not mediated by AM404.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(9):1689-95.
2011: Vincenzo Brancaleone; Jesmond Dalli; Stefania Bena; Roderick J Flower; Giuseppe Cirino; Mauro Perretti
Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(8):4905-14.
2011: Paul M Holloway; Helen K Smith; Derek Renshaw; Roderick J Flower; Stephen J Getting; Felicity N E Gavins
Targeting the melanocortin receptor system for anti-stroke therapy.
Trends in pharmacological sciences 2011;32(2):90-8.
2011: Amilcar Sabino Damazo; Roderick J Flower; Cintia Mag Nakata; Mauro Perretti; André Lf Sampaio; Sonia Maria Oliani
Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis.
BMC immunology 2011;12():59.
2010: Samia Yazid; Giovanna Leoni; Stephen J Getting; Dianne Cooper; Egle Solito; Mauro Perretti; Roderick J Flower
Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(9):1718-24.
2010: Samia Yazid; Samir S Ayoub; Egle Solito; Simon McArthur; PA Vo; Neil Dufton; Roderick J Flower
Anti-allergic drugs and the Annexin-A1 system.
Pharmacological reports : PR 2010;62(3):511-7.
2010: Neil Dufton; Robert Hannon; Vincenzo Brancaleone; Jesmond Dalli; Hetal B Patel; Mohini Gray; Fulvio D'Acquisto; Julia C Buckingham; Mauro Perretti; Roderick J Flower
Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(5):2611-9.
2010: Nikolaos Paschalidis; Anthony Huggins; Nicola J Rowbotham; Anna L Furmanski; Tessa Crompton; Roderick J Flower; Mauro Perretti; Fulvio D'Acquisto
Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection.
Cell cycle (Georgetown, Tex.) 2010;9(4):784-93.
2010: Roderick J Flower
In vitro cyclo-oxygenase expression and activity protocols: Introduction to Part I.
Methods in molecular biology (Clifton, N.J.) 2010;644():3-10.
2009: Christopher Bolton; Elizabeth G Wood; Gwen S Scott; Roderick J Flower
A comparative evaluation of the response to peroxynitrite by a brain endothelial cell line and control of the effects by drug targeting.
Cellular and molecular neurobiology 2009;29(5):707-17.
2009: Anthony Huggins; Nikolaos Paschalidis; Roderick J Flower; Mauro Perretti; Fulvio D'Acquisto
Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(4):985-96.
2009: Thaís Santana Gastardelo; Amilcar Sabino Damazo; Jesmond Dalli; Roderick J Flower; Mauro Perretti; Sonia Maria Oliani
Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation.
The American journal of pathology 2009;174(1):177-83.
2008: Samir S Ayoub; S Yazid; Roderick J Flower
Increased susceptibility of annexin-A1 null mice to nociceptive pain is indicative of a spinal antinociceptive action of annexin-A1.
British journal of pharmacology 2008;154(5):1135-42.
2008: Fulvio D'Acquisto; N Paschalidis; K Raza; C D Buckley; Roderick J Flower; Mauro Perretti
Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid arthritis CD4+ T cells.
Rheumatology (Oxford, England) 2008;47(5):636-9.
2008: A S Damazo; Roderick J Flower; E Solito; Sonia Maria Oliani
Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2008;57(3):97-103.
2007: Felicity N E Gavins; Jesmond Dalli; Roderick J Flower; D Neil Granger; Mauro Perretti
Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(8):1751-8.
2007: Fulvio D'Acquisto; Ahmed Merghani; Emilio Lecona; Guglielmo Rosignoli; Karim Raza; Christopher D Buckley; Roderick J Flower; Mauro Perretti
Annexin-1 modulates T-cell activation and differentiation.
Blood 2007;109(3):1095-102.
2006: Simon Yona; Sigrid E M Heinsbroek; Leanne Peiser; Siamon Gordon; Mauro Perretti; Roderick J Flower
Impaired phagocytic mechanism in annexin 1 null macrophages.
British journal of pharmacology 2006;148(4):469-77.
2006: Amilcar Sabino Damazo; Simon Yona; Roderick J Flower; Mauro Perretti; Sonia Maria Oliani
Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4410-8.
2006: Richard P G Hayhoe; Ahmad M Kamal; Egle Solito; Roderick J Flower; Dianne Cooper; Mauro Perretti
Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement.
Blood 2006;107(5):2123-30.
2006: Ahmad M Kamal; Richard P G Hayhoe; Anbalakan Paramasivam; Dianne Cooper; Roderick J Flower; Egle Solito; Mauro Perretti
Antiflammin-2 activates the human formyl-peptide receptor like 1.
TheScientificWorldJournal 2006;6():1375-84.
2006: Roderick J Flower
Prostaglandins, bioassay and inflammation.
British journal of pharmacology 2006;147 Suppl 1():S182-92.
2005: Leonardo A Moraes; Mark Paul-Clark; Alice Rickman; Roderick J Flower; Nicolas J Goulding; Mauro Perretti
Ligand-specific glucocorticoid receptor activation in human platelets.
Blood 2005;106(13):4167-75.
2005: Bristi E Chatterjee; Simon Yona; Guglielmo Rosignoli; Rebecca E Young; Sussan Nourshargh; Roderick J Flower; Mauro Perretti
Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro.
Journal of leukocyte biology 2005;78(3):639-46.
2005: Amilcar Sabino Damazo; Simon Yona; Fulvio D'Acquisto; Roderick J Flower; Sonia Maria Oliani; Mauro Perretti
Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation.
The American journal of pathology 2005;166(6):1607-17.
2005: Roderick J Flower; Mauro Perretti
Controlling inflammation: a fat chance?
The Journal of experimental medicine 2005;201(5):671-4.
2005: Simon Yona; Barbara Ward; Julia C Buckingham; Mauro Perretti; Roderick J Flower
Macrophage biology in the Anx-A1-/- mouse.
Prostaglandins, leukotrienes, and essential fatty acids 2005;72(2):95-103.
2004: Simon Yona; Julia C Buckingham; Mauro Perretti; Roderick J Flower
Stimulus-specific defect in the phagocytic pathways of annexin 1 null macrophages.
British journal of pharmacology 2004;142(5):890-8.
2004: Yuan H Yang; Eric F Morand; Stephen J Getting; Mark Paul-Clark; Dong L Liu; Simon Yona; Robert Hannon; Julia C Buckingham; Mauro Perretti; Roderick J Flower
Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis.
Arthritis and rheumatism 2004;50(3):976-84.
2003: Mark Paul-Clark; Fiorentina Roviezzo; Roderick J Flower; Giuseppe Cirino; Piero Del Soldato; Ian M Adcock; Mauro Perretti
Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3245-52.
2003: Felicity N E Gavins; Simon Yona; Ahmad M Kamal; Roderick J Flower; Mauro Perretti
Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms.
Blood 2003;101(10):4140-7.
2003: Mauro Perretti; Mark Paul-Clark; Lucia Mancini; Roderick J Flower
Generation of innovative anti-inflammatory and anti-arthritic glucocorticoid derivatives that release NO: the nitro-steroids.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2003;35 Suppl 2():S41-8.
2003: Jamie Croxtall; Derek W Gilroy; Egle Solito; Qamrul Choudhury; Barbara J Ward; Julia C Buckingham; Roderick J Flower
Attenuation of glucocorticoid functions in an Anx-A1-/- cell line.
The Biochemical journal 2003;371(Pt 3):927-35.
2003: Stephen J Getting; Helen C Christian; Connie W Lam; Felicity N E Gavins; Roderick J Flower; Helgi B Schiöth; Mauro Perretti
Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3323-30.
2003: Roderick J Flower
The development of COX2 inhibitors.
Nature reviews. Drug discovery 2003;2(3):179-91.
2003: Robert Hannon; Jamie Croxtall; Stephen J Getting; Fiorentina Roviezzo; Simon Yona; Mark Paul-Clark; Felicity N E Gavins; Mauro Perretti; John F Morris; Julia C Buckingham; Roderick J Flower
Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):253-5.
2002: Fiorentina Roviezzo; Stephen J Getting; Mark Paul-Clark; Simon Yona; Felicity N E Gavins; Mauro Perretti; Robert Hannon; Jamie Croxtall; Julia C Buckingham; Roderick J Flower
The annexin-1 knockout mouse: what it tells us about the inflammatory response.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2002;53(4 Pt 1):541-53.
2002: Stephen J Getting; Helen C Christian; Roderick J Flower; Mauro Perretti
Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis.
Arthritis and rheumatism 2002;46(10):2765-75.
2002: Mark Paul-Clark; Lucia Mancini; Piero Del Soldato; Roderick J Flower; Mauro Perretti
Potent antiarthritic properties of a glucocorticoid derivative, NCX-1015, in an experimental model of arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1677-82.
2002: Qamrul Choudhury; Diane T Mckay; Roderick J Flower; Jamie Croxtall
Investigation into the involvement of phospholipases A2 and map kinases in modulation of AA release and cell growth in A549 cells.
Advances in experimental medicine and biology 2002;507():33-40.
2002: Jamie Croxtall; Peter Th W van Hal; Qamrul Choudhury; Derek W Gilroy; Roderick J Flower
Different glucocorticoids vary in their genomic and non-genomic mechanism of action in A549 cells.
British journal of pharmacology 2002;135(2):511-9.
2001: Mylinh La; Michele D'Amico; S Bandiera; C Di Filippo; Sonia Maria Oliani; Felicity N E Gavins; Roderick J Flower; Mauro Perretti
Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(12):2247-56.
2001: Sonia Maria Oliani; Mark Paul-Clark; H C Christian; Roderick J Flower; Mauro Perretti
Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression.
The American journal of pathology 2001;158(2):603-15.
2000: Mark Paul-Clark; Piero Del Soldato; S Fiorucci; Roderick J Flower; Mauro Perretti
21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties.
British journal of pharmacology 2000;131(7):1345-54.
2000: Michele D'Amico; C Di Filippo; Mylinh La; Egle Solito; peter g mclean; Roderick J Flower; Sonia Maria Oliani; Mauro Perretti
Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):1867-9.
2000: Sonia Maria Oliani; H C Christian; J Manston; Roderick J Flower; Mauro Perretti
An immunocytochemical and in situ hybridization analysis of annexin 1 expression in rat mast cells: modulation by inflammation and dexamethasone.
Laboratory investigation; a journal of technical methods and pathology 2000;80(9):1429-38.
2000: Qamrul Choudhury; D T McKay; Roderick J Flower; Jamie Croxtall
Investigation into the involvement of phospholipases A(2) and MAP kinases in modulation of AA release and cell growth in A549 cells.
British journal of pharmacology 2000;131(2):255-65.
2000: Lina Lim; Roderick J Flower; Mauro Perretti; AM Das
Glucocorticoid receptor activation reduces CD11b and CD49d levels on murine eosinophils: characterization and functional relevance.
American journal of respiratory cell and molecular biology 2000;22(6):693-701.
2000: Jamie Croxtall; Qamrul Choudhury; Roderick J Flower
Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism.
British journal of pharmacology 2000;130(2):289-98.
2000: S Canaider; Egle Solito; Catherine de Coupade; Roderick J Flower; Françoise Russo-Marie; Nicolas J Goulding; Mauro Perretti
Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I).
Life sciences 2000;66(18):PL265-70.
2000: Mauro Perretti; H Christian; Samantha K Wheller; I Aiello; K G Mugridge; John F Morris; Roderick J Flower; Nicolas J Goulding
Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis.
Cell biology international 2000;24(3):163-74.
1999: Stephen J Getting; Roderick J Flower; Mauro Perretti
Agonism at melanocortin receptor type 3 on macrophages inhibits neutrophil influx.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48 Suppl 2():S140-1.
1999: A Tailor; A Tomlinson; A Salas; J Panés; D N Granger; Roderick J Flower; Mauro Perretti
Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC.
Gut 1999;45(5):705-12.
1999: AM Das; MN Ajuebor; Roderick J Flower; Mauro Perretti; S R McColl
Contrasting roles for RANTES and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in a murine model of allergic peritonitis.
Clinical and experimental immunology 1999;117(2):223-9.
1999: S J Getting; L Gibbs; A J Clark; Roderick J Flower; Mauro Perretti
POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(12):7446-53.
1999: Mauro Perretti; Samantha K Wheller; Roderick J Flower; Smaira Wahid; Costantino Pitzalis
Modulation of cellular annexin I in human leukocytes infiltrating DTH skin reactions.
Journal of leukocyte biology 1999;65(5):583-9.
1999: MN Ajuebor; AM Das; Laszlo Virag; Roderick J Flower; Csaba Szabó; Mauro Perretti
Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1685-91.
1999: H S Euzger; Roderick J Flower; Nicolas J Goulding; Mauro Perretti
Differential modulation of annexin I binding sites on monocytes and neutrophils.
Mediators of inflammation 1999;8(1):53-62.
1998: MN Ajuebor; Laszlo Virag; Roderick J Flower; Mauro Perretti; Csaba Szabó
Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation.
Immunology 1998;95(4):625-30.
1998: Lina Lim; Egle Solito; Françoise Russo-Marie; Roderick J Flower; Mauro Perretti
Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14535-9.
1998: MN Ajuebor; L Gibbs; Roderick J Flower; AM Das; Mauro Perretti
Investigation of the functional role played by the chemokine monocyte chemoattractant protein-1 in interleukin-1-induced murine peritonitis.
British journal of pharmacology 1998;125(2):319-26.
1998: A M Das; Roderick J Flower; Mauro Perretti
Resident mast cells are important for eotaxin-induced eosinophil accumulation in vivo.
Journal of leukocyte biology 1998;64(2):156-62.
1998: Egle Solito; Catherine de Coupade; Luca Parente; Roderick J Flower; Françoise Russo-Marie
IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein.
Cytokine 1998;10(7):514-21.
1998: Egle Solito; Catherine de Coupade; Luca Parente; Roderick J Flower; Françoise Russo-Marie
Human annexin 1 is highly expressed during the differentiation of the epithelial cell line A 549: involvement of nuclear factor interleukin 6 in phorbol ester induction of annexin 1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1998;9(4):327-36.
1998: Jamie Croxtall; Qamrul Choudhury; Roderick J Flower
Inhibitory effect of peptides derived from the N-terminus of lipocortin 1 on arachidonic acid release and proliferation in the A549 cell line: identification of E-Q-E-Y-V as a crucial component.
British journal of pharmacology 1998;123(5):975-83.
1998: C E Bryant; Mauro Perretti; Roderick J Flower
Suppression by dexamethasone of inducible nitric oxide synthase protein expression in vivo: a possible role for lipocortin 1.
Biochemical pharmacology 1998;55(3):279-85.
1998: MN Ajuebor; Roderick J Flower; R Hannon; M Christie; K Bowers; A Verity; Mauro Perretti
Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model.
Journal of leukocyte biology 1998;63(1):108-16.
1997: Jamie Croxtall; Qamrul Choudhury; J O White; Roderick J Flower
Tamoxifen inhibits the release of arachidonic acid stimulated by thapsigargin in estrogen receptor-negative A549 cells.
Biochimica et biophysica acta 1997;1349(3):275-84.
1997: N J Willmott; Qamrul Choudhury; Roderick J Flower
Effects of dexamethasone and phorbol ester on P2 receptor-coupled Ca2+ signalling and lipocortin 1 presentation in U937 cells.
British journal of pharmacology 1997;122(6):1055-60.
1997: Stephen J Getting; Roderick J Flower; L Parente; R de Medicis; A Lussier; B A Woliztky; M A Martins; Mauro Perretti
Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins.
The Journal of pharmacology and experimental therapeutics 1997;283(1):123-30.
1997: A Tailor; Roderick J Flower; Mauro Perretti
Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: an intravital microscopy study.
Journal of leukocyte biology 1997;62(3):301-8.
1997: AM Das; Roderick J Flower; Mauro Perretti
Eotaxin-induced eosinophil migration in the peritoneal cavity of ovalbumin-sensitized mice: mechanism of action.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1466-73.
1997: A M Das; Roderick J Flower; P G Hellewell; Mauro Teixeira; Mauro Perretti
A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment.
British journal of pharmacology 1997;121(1):97-104.
1997: Stephen J Getting; Roderick J Flower; Mauro Perretti
Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1.
British journal of pharmacology 1997;120(6):1075-82.
1997: A Tailor; A M Das; Stephen J Getting; Roderick J Flower; Mauro Perretti
Subacute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes.
Biochemical and biophysical research communications 1997;231(3):675-8.
1997: AM Das; Roderick J Flower; Lina Lim; Mauro Perretti
Dexamethasone reduces cell surface levels of CD11b on human eosinophils.
Mediators of inflammation 1997;6(5-6):363-7.
1997: S P Newman; Jamie Croxtall; Qamrul Choudhury; Roderick J Flower
The co-ordinate regulation of lipocortin 1, COX 2 and cPLA2 by IL-1 beta in A549 cells.
Advances in experimental medicine and biology 1997;407():249-53.
1996: Mauro Perretti; Jamie Croxtall; Samantha K Wheller; N J Goulding; R Hannon; Roderick J Flower
Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration.
Nature medicine 1996;2(11):1259-62.
1996: Jamie Croxtall; Qamrul Choudhury; S Newman; Roderick J Flower
Lipocortin 1 and the control of cPLA2 activity in A549 cells. Glucocorticoids block EGF stimulation of cPLA2 phosphorylation.
Biochemical pharmacology 1996;52(2):351-6.
1996: Mauro Perretti; Samantha K Wheller; J G Harris; Roderick J Flower
Modulation of ICAM-1 levels on U-937 cells and mouse macrophages by interleukin-1 beta and dexamethasone.
Biochemical and biophysical research communications 1996;223(1):112-7.
1996: Mauro Perretti; Roderick J Flower
Measurement of lipocortin 1 levels in murine peripheral blood leukocytes by flow cytometry: modulation by glucocorticoids and inflammation.
British journal of pharmacology 1996;118(3):605-10.
1996: J G Harris; Roderick J Flower; K Watanabe; S Tsurufuji; B A Wolitzky; Mauro Perretti
Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC).
Biochemical and biophysical research communications 1996;221(3):692-6.
1996: J D Croxtal; S P Newman; Qamrul Choudhury; Roderick J Flower
The concerted regulation of cPLA2, COX2, and lipocortin 1 expression by IL-1beta in A549 cells.
Biochemical and biophysical research communications 1996;220(3):491-5.
1996: Mauro Perretti; A Ahluwalia; J G Harris; H J Harris; Samantha K Wheller; Roderick J Flower
Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1.
British journal of pharmacology 1996;117(6):1145-54.
1995: Mauro Perretti; Samantha K Wheller; Qamrul Choudhury; Jamie Croxtall; Roderick J Flower
Selective inhibition of neutrophil function by a peptide derived from lipocortin 1 N-terminus.
Biochemical pharmacology 1995;50(7):1037-42.
1995: J G Harris; Roderick J Flower; Mauro Perretti
Endogenous corticosteroids mediate the neutrophilia caused by platelet-activating factor in the mouse.
European journal of pharmacology 1995;283(1-3):9-18.
1995: A Ahluwalia; P Newbold; S D Brain; Roderick J Flower
Topical glucocorticoids inhibit neurogenic inflammation: involvement of lipocortin 1.
European journal of pharmacology 1995;283(1-3):193-8.
1995: Jamie Croxtall; Qamrul Choudhury; H Tokumoto; Roderick J Flower
Lipocortin-1 and the control of arachidonic acid release in cell signalling. Glucocorticoids (changed from glucorticoids) inhibit G protein-dependent activation of cPLA2 activity.
Biochemical pharmacology 1995;50(4):465-74.
1995: F Mancuso; Roderick J Flower; Mauro Perretti
Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule. Involvement of endogenous lipocortin 1.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):377-86.
1995: SF Smith; Teresa D Tetley; Avijit Kumar Datta; Terence Smith; A Guz; Roderick J Flower
Lipocortin-1 distribution in bronchoalveolar lavage from healthy human lung: effect of prednisolone.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;79(1):121-8.
1995: J G Harris; Roderick J Flower; Mauro Perretti
Alteration of neutrophil trafficking by a lipocortin 1 N-terminus peptide.
European journal of pharmacology 1995;279(2-3):149-57.
1995: C C Wu; Jamie Croxtall; Mauro Perretti; C E Bryant; Christoph Thiemermann; Roderick J Flower; JR Vane
Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3473-7.
1995: S H Peers; G S Duncan; Roderick J Flower; C Bolton
Endogenous corticosteroids modulate lymphoproliferation and susceptibility to experimental allergic encephalomyelitis in the Brown Norway rat.
International archives of allergy and immunology 1995;106(1):20-4.
1995: Roderick J Flower
New frontiers in the pharmacotherapy of inflammation.
Agents and actions. Supplements 1995;46():169-78.
1995: Mauro Perretti; Roderick J Flower
Anti-inflammatory lipocortin-derived peptides.
Agents and actions. Supplements 1995;46():131-8.
1994: Jamie Croxtall; Roderick J Flower
Antisense oligonucleotides to human lipocortin-1 inhibit glucocorticoid-induced inhibition of A549 cell growth and eicosanoid release.
Biochemical pharmacology 1994;48(9):1729-34.
1994: A Ahluwalia; R W Mohamed; Roderick J Flower
Induction of lipocortin 1 by topical steroid in rat skin.
Biochemical pharmacology 1994;48(8):1647-54.
1994: S P Newman; Roderick J Flower; Jamie Croxtall
Dexamethasone suppression of IL-1 beta-induced cyclooxygenase 2 expression is not mediated by lipocortin-1 in A549 cells.
Biochemical and biophysical research communications 1994;202(2):931-9.
1994: Mauro Perretti; Roderick J Flower
Cytokines, glucocorticoids and lipocortins in the control of neutrophil migration.
Pharmacological research : the official journal of the Italian Pharmacological Society 1994;30(1):53-9.
1994: Mauro Perretti; J G Harris; Roderick J Flower
A role for endogenous histamine in interleukin-8-induced neutrophil infiltration into mouse air-pouch: investigation of the modulatory action of systemic and local dexamethasone.
British journal of pharmacology 1994;112(3):801-8.
1994: H Tokumoto; Jamie Croxtall; Roderick J Flower
Differential role of extra- and intracellular calcium in bradykinin and interleukin 1 alpha stimulation of arachidonic acid release from A549 cells.
Biochimica et biophysica acta 1994;1211(3):301-9.
1994: Roderick J Flower; N J Rothwell
Lipocortin-1: cellular mechanisms and clinical relevance.
Trends in pharmacological sciences 1994;15(3):71-6.
1994: Jamie Croxtall; C Emmas; J O White; Q Choudhary; Roderick J Flower
Tamoxifen inhibits growth of oestrogen receptor-negative A549 cells.
Biochemical pharmacology 1994;47(2):197-202.
1993: A J Elderfield; Christopher Bolton; Roderick J Flower
Lipocortin 1 (annexin 1) immunoreactivity in the cervical spinal cord of Lewis rats with acute experimental allergic encephalomyelitis.
Journal of the neurological sciences 1993;119(2):146-53.
1993: Mauro Perretti; A Ahluwalia; J G Harris; N J Goulding; Roderick J Flower
Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):4306-14.
1993: Mauro Perretti; G S Duncan; Roderick J Flower; S H Peers
Serum corticosterone, interleukin-1 and tumour necrosis factor in rat experimental endotoxaemia: comparison between Lewis and Wistar strains.
British journal of pharmacology 1993;110(2):868-74.
1993: H Tokumoto; Jamie Croxtall; Qamrul Choudhury; Roderick J Flower
Phospholipase A2-induced stimulation of A549 lung adenocarcinoma cell line proliferation.
Biochimica et biophysica acta 1993;1169(3):236-42.
1993: Mauro Perretti; A Ahluwalia; Roderick J Flower; S Manzini
Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors.
Immunology 1993;80(1):73-7.
1993: S H Peers; G S Duncan; Roderick J Flower
Development of specific antibody and in vivo response to antigen in different rat strains: effect of dexamethasone and importance of endogenous corticosteroids.
Agents and actions 1993;39(3-4):174-81.
1993: Mauro Perretti; Roderick J Flower; N J Goulding
The ability of murine leukocytes to bind lipocortin 1 is lost during acute inflammation.
Biochemical and biophysical research communications 1993;192(2):345-50.
1993: Jamie Croxtall; S Waheed; Qamrul Choudhury; R Anand; Roderick J Flower
N-terminal peptide fragments of lipocortin-1 inhibit A549 cell growth and block EGF-induced stimulation of proliferation.
International journal of cancer. Journal international du cancer 1993;54(1):153-8.
1993: A Ahluwalia; Roderick J Flower
Investigations into the mechanism of vasoconstrictor action of the topical steroid betamethasone-17-valerate in the rat.
British journal of pharmacology 1993;108(2):544-8.
1993: Mauro Perretti; Roderick J Flower
Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):992-9.
1993: S H Peers; F Smillie; A J Elderfield; Roderick J Flower
Glucocorticoid-and non-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo.
British journal of pharmacology 1993;108(1):66-72.
1993: G S Duncan; S H Peers; F Carey; R Forder; Roderick J Flower
The local anti-inflammatory action of dexamethasone in the rat carrageenin oedema model is reversed by an antiserum to lipocortin 1.
British journal of pharmacology 1993;108(1):62-5.
1993: A Ahluwalia; Roderick J Flower
Topical betamethasone-17-valerate inhibits heat-induced vasodilatation in man.
The British journal of dermatology 1993;128(1):45-8.
1993: Mauro Perretti; I Appleton; L Parente; Roderick J Flower
Pharmacology of interleukin-1-induced neutrophil migration.
Agents and actions 1993;38 Spec No():C64-5.
1993: A Ahluwalia; Roderick J Flower
Effect of chronic capsaicin and guanethidine treatment on skin blood flow of the rat.
Agents and actions 1993;38 Spec No():C16-8.
1992: C T Murphy; S H Peers; R A Forder; Roderick J Flower; F Carey; John Westwick
Evidence for the presence and location of annexins in human platelets.
Biochemical and biophysical research communications 1992;189(3):1739-46.
1992: M R Podgorski; N J Goulding; ND Hall; Roderick J Flower; P J Maddison
Autoantibodies to lipocortin-1 are associated with impaired glucocorticoid responsiveness in rheumatoid arthritis.
The Journal of rheumatology 1992;19(11):1668-71.
1992: Garry Douglas; Roderick J Flower; L Parente; Mauro Perretti
Peptide 204-212 of lipocortin 5 inhibits the generation of a prostacyclin-like factor from rat aorta preparations in vitro.
Prostaglandins 1992;44(5):381-8.
1992: A J Elderfield; J Newcombe; Christopher Bolton; Roderick J Flower
Lipocortins (annexins) 1, 2, 4 and 5 are increased in the central nervous system in multiple sclerosis.
Journal of neuroimmunology 1992;39(1-2):91-100.
1992: A Ahluwalia; S H Peers; Roderick J Flower
Steroid inhibition of oedema formation in the rat skin.
British journal of pharmacology 1992;106(3):628-31.
1992: Jamie Croxtall; Roderick J Flower
Lipocortin 1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3571-5.
1991: S H Peers; Roderick J Flower
Site of anti-inflammatory action of dexamethasone in rabbit skin.
European journal of pharmacology 1991;196(1):37-41.
1991: Garry Douglas; KI Williams; Roderick J Flower
Characterization of Gaddum's substance R.
British journal of pharmacology 1991;102(4):926-30.
1991: K Fan Chung; M R Podgorski; N J Goulding; J L Godolphin; P R Sharland; B O'Connor; Roderick J Flower; Peter J Barnes
Circulating autoantibodies to recombinant lipocortin-1 in asthma.
Respiratory medicine 1991;85(2):121-4.
1990: J K Rivers; M R Podgorski; N J Goulding; E Wong; J A McGrath; Roderick J Flower; Malcolm W Greaves
The presence of autoantibody to recombinant lipocortin-I in patients with psoriasis and psoriatic arthritis.
The British journal of dermatology 1990;123(5):569-72.
1990: Christopher Bolton; A J Elderfield; Roderick J Flower
The detection of lipocortins 1, 2 and 5 in central nervous system tissues from Lewis rats with acute experimental allergic encephalomyelitis.
Journal of neuroimmunology 1990;29(1-3):173-81.
1990: SF Smith; N J Goulding; J L Godolphin; Teresa D Tetley; C M Roberts; A Guz; Roderick J Flower
An assay for the assessment of lipocortin 1 levels in human lung lavage fluid.
Journal of immunological methods 1990;131(1):119-25.
1990: N J Goulding; J L Godolphin; P R Sharland; S H Peers; M Sampson; P J Maddison; Roderick J Flower
Anti-inflammatory lipocortin 1 production by peripheral blood leucocytes in response to hydrocortisone.
Lancet 1990;335(8703):1416-8.
1990: SF Smith; Teresa D Tetley; A Guz; Roderick J Flower
Detection of lipocortin 1 in human lung lavage fluid: lipocortin degradation as a possible proteolytic mechanism in the control of inflammatory mediators and inflammation.
Environmental health perspectives 1990;85():135-44.
1990: N J Goulding; J L Godolphin; M B Sampson; P J Maddison; Roderick J Flower
Hydrocortisone induces lipocortin 1 production by peripheral blood mononuclear cells in vivo in man.
Biochemical Society transactions 1990;18(2):306-7.
1990: S H Peers; Roderick J Flower
The role of lipocortin in corticosteroid actions.
The American review of respiratory disease 1990;141(2 Pt 2):S18-21.
1989: N J Goulding; M R Podgorski; ND Hall; Roderick J Flower; J L Browning; R B Pepinsky; P J Maddison
Autoantibodies to recombinant lipocortin-1 in rheumatoid arthritis and systemic lupus erythematosus.
Annals of the rheumatic diseases 1989;48(10):843-50.
1989: Giuseppe Cirino; S H Peers; J L Wallace; Roderick J Flower
A study of phospholipase A2-induced oedema in rat paw.
European journal of pharmacology 1989;166(3):505-10.
1989: Giuseppe Cirino; S H Peers; Roderick J Flower; J L Browning; R B Pepinsky
Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3428-32.
1989: Christopher Bolton; Roderick J Flower
The effects of the anti-glucocorticoid RU 38486 on steroid-mediated suppression of experimental allergic encephalomyelitis (EAE) in the Lewis rat.
Life sciences 1989;45(1):97-104.
1988: Roderick J Flower
Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids.
British journal of pharmacology 1988;94(4):987-1015.
1988: S H Peers; D Moon; Roderick J Flower
Reversal of the anti-inflammatory effects of dexamethasone by the glucocorticoid antagonist RU 38486.
Biochemical pharmacology 1988;37(3):556-7.
1987: S H Peers; R D Taylor; Roderick J Flower
A novel binding assay for phospholipase A2.
Biochemical pharmacology 1987;36(24):4287-91.
1987: Giuseppe Cirino; Roderick J Flower
Human recombinant lipocortin 1 inhibits prostacyclin production by human umbilical artery in vitro.
Prostaglandins 1987;34(1):59-62.
1987: Roderick J Flower
Lipocortins.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():577-80.