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Daniel Flynn

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Brandi N Snyder; YoungJin Cho; Yong Qian; James E Coad; Daniel C Flynn; Jess M Cunnick
AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes.
David A Clump; Jing Jie Yu; Youngjin Cho; Rui Gao; John Jett; Henry Zot; Jess M Cunnick; Brandi Snyder; Anne C Clump; Melissa Dodrill; Peter Gannett; James E Coad; Robert Shurina; W Douglas Figg; Eddie Reed; Daniel C Flynn
A Polymorphic Variant of AFAP-110 Enhances cSrc Activity.
Patrick L Apopa; Yong Qian; Rong Shao; Nancy Lan Guo; Diane Schwegler-Berry; Maricica Pacurari; Dale Porter; Xianglin Shi; Val Vallyathan; Vincent Castranova; Daniel C Flynn
Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling.

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All Publications

2011: Brandi N Snyder; YoungJin Cho; Yong Qian; James E Coad; Daniel C Flynn; Jess M Cunnick
AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes.
European journal of cell biology 2011;90(5):376-89.
2010: David A Clump; Jing Jie Yu; Youngjin Cho; Rui Gao; John Jett; Henry Zot; Jess M Cunnick; Brandi Snyder; Anne C Clump; Melissa Dodrill; Peter Gannett; James E Coad; Robert Shurina; W Douglas Figg; Eddie Reed; Daniel C Flynn
A Polymorphic Variant of AFAP-110 Enhances cSrc Activity.
Translational oncology 2010;3(4):276-85.
2009: Patrick L Apopa; Yong Qian; Rong Shao; Nancy Lan Guo; Diane Schwegler-Berry; Maricica Pacurari; Dale Porter; Xianglin Shi; Val Vallyathan; Vincent Castranova; Daniel C Flynn
Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling.
Particle and fibre toxicology 2009;6():1.
2008: Andrea Dorfleutner; Youngjin Cho; Deanne Vincent; Jess Cunnick; Hong Lin; Scott A Weed; Christian Stehlik; Daniel C Flynn
Phosphorylation of AFAP-110 affects podosome lifespan in A7r5 cells.
Journal of cell science 2008;121(Pt 14):2394-405.
2007: Yong Qian; Jia Luo; Stephen S Leonard; Gabriel K Harris; Lyndell Millecchia; Daniel C Flynn; Xianglin Shi
Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis.
Nihon Arukōru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 2007;42(6):605-9.
2007: Andrea Dorfleutner; Siera J Talbott; Nicole B Bryan; Kristin N Funya; Stephanie L Rellick; John C Reed; Xianglin Shi; Yon Rojanasakul; Daniel C Flynn; Christian Stehlik
A Shope Fibroma virus PYRIN-only protein modulates the host immune response.
Virus genes 2007;35(3):685-94.
2007: Andrea Dorfleutner; Christian Stehlik; Jing Zhang; Gary E Gallick; Daniel C Flynn
AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells.
Journal of cellular physiology 2007;213(3):740-9.
2007: Jing Zhang; Serk In Park; Marlene C Artime; Justin M Summy; Ami N Shah; Joshua A Bomser; Andrea Dorfleutner; Daniel C Flynn; Gary E Gallick
AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts.
The Journal of clinical investigation 2007;117(10):2962-73.
2007: Valerie G Walker; Amanda Ammer; Zongxian Cao; Anne C Clump; Bing-Hua Jiang; Laura C Kelley; Scott A Weed; Henry Zot; Daniel C Flynn
PI3K activation is required for PMA-directed activation of cSrc by AFAP-110.
American journal of physiology. Cell physiology 2007;293(1):C119-32.
2007: Yan Ma; Yong Qian; Liang Wei; Jame Abraham; Xianglin Shi; Vincent Castranova; E James Harner; Daniel C Flynn; Lan Guo
Population-based molecular prognosis of breast cancer by transcriptional profiling.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2014-22.
2007: Andrea Dorfleutner; Nicole B Bryan; Siera J Talbott; Kristin N Funya; Stephanie L Rellick; John C Reed; Xianglin Shi; Yon Rojanasakul; Daniel C Flynn; Christian Stehlik
Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.
Infection and immunity 2007;75(3):1484-92.
2006: Brooke Helfer; Bernard C Boswell; Darren Finlay; Angel Cipres; Kristiina Vuori; Tae Bong Kang; David Wallach; Andrea Dorfleutner; Jill Lahti; Daniel C Flynn; Steven M Frisch
Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions.
Cancer research 2006;66(8):4273-8.
2006: Bing-Hua Jiang; Ling-Zhi Liu; Rosana Schafer; Daniel C Flynn; John Barnett
A novel role for 3, 4-dichloropropionanilide (DCPA) in the inhibition of prostate cancer cell migration, proliferation, and hypoxia-inducible factor 1alpha expression.
BMC cancer 2006;6():204.
2005: David A Clump; Ihtishaam H Qazi; Marius Sudol; Daniel C Flynn
c-Yes response to growth factor activation.
Growth factors (Chur, Switzerland) 2005;23(4):263-72.
2005: Yong Qian; Xiaosong Zhong; Daniel C Flynn; Jenny Z Zheng; Meng Qiao; Chuanyue Wu; Shoukat Dedhar; Xianglin Shi; Bing-Hua Jiang
ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling.
Oncogene 2005;24(19):3154-65.
2005: X Li; G Wang; J Zhao; H Ding; C Cunningham; F Chen; Daniel C Flynn; Eddie Reed; Qingdi Q Li
Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase.
Cellular and molecular life sciences : CMLS 2005;62(7-8):894-904.
2005: G Wang; X Li; F Huang; J Zhao; H Ding; C Cunningham; J E Coad; Daniel C Flynn; Eddie Reed; Qingdi Q Li
Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death.
Cellular and molecular life sciences : CMLS 2005;62(7-8):881-93.
2005: Yong Qian; Ke Jian Liu; Yan Chen; Daniel C Flynn; Vincent Castranova; Xianglin Shi
Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization.
The Journal of biological chemistry 2005;280(5):3875-84.
2004: Amanda Gatesman; Valerie G Walker; Joseph M Baisden; Scott A Weed; Daniel C Flynn
Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110.
Molecular and cellular biology 2004;24(17):7578-97.
2004: Ning Gao; Daniel C Flynn; Zhuo Zhang; Xiao-Song Zhong; Valerie Walker; Ke Jian Liu; Xianglin Shi; Bing-Hua Jiang
G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells.
American journal of physiology. Cell physiology 2004;287(2):C281-91.
2004: Yong Qian; Amanda Gatesman; Joseph M Baisden; Henry G Zot; Lidia Cherezova; Ihtishaam Qazi; Nayef Mazloum; Marietta Y Lee; Anne Guappone-Koay; Daniel C Flynn
Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity.
Journal of cellular biochemistry 2004;91(3):602-20.
2004: Marycharmain Belcastro; Michael R Miller; Daniel C Flynn; Andrew P Soisson
C/EBPbeta activity and HPV-16 E6/E7 mRNA expression are not altered by imiquimod (ALDARA) in human cervical cancer cells in vitro.
Gynecologic oncology 2004;92(2):660-8.
2004: Yong Qian; Linda Corum; Qiao Meng; John Blenis; Jenny Z Zheng; Xianglin Shi; Daniel C Flynn; Bing-Hua Jiang
PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration.
American journal of physiology. Cell physiology 2004;286(1):C153-63.
2003: Justin M Summy; Yong Qian; Bing-Hua Jiang; Anne Guappone-Koay; Amanda Gatesman; Xianglin Shi; Daniel C Flynn
The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src.
Journal of cell science 2003;116(Pt 12):2585-98.
2003: Yong Qian; Jia Luo; Stephen S Leonard; Gabriel K Harris; Lyndell Millecchia; Daniel C Flynn; Xianglin Shi
Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis.
The Journal of biological chemistry 2003;278(18):16189-97.
2003: David A Clump; Roger Clem; Yong Qian; Anne Guappone-Koay; Albert S Berrebi; Daniel C Flynn
Protein expression levels of the Src activating protein AFAP are developmentally regulated in brain.
Journal of neurobiology 2003;54(3):473-85.
2003: Justin M Summy; Marius Sudol; Michael J Eck; Alvaro Monteiro; Amanda Gatesman; Daniel C Flynn
Specificity in signaling by c-Yes.
Frontiers in bioscience : a journal and virtual library 2003;8():s185-205.
2002: Ning Gao; Bing-Hua Jiang; Stephen S Leonard; Linda Corum; Zhuo Zhang; Jenny R Roberts; Jim Antonini; Jenny Z Zheng; Daniel C Flynn; Vincent Castranova; Xianglin Shi
p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells.
The Journal of biological chemistry 2002;277(47):45041-8.
2002: Yong Qian; Joseph M Baisden; Lidia Cherezova; Justin M Summy; Anne Guappone-Koay; Xianglin Shi; Tom Mast; Jennifer Pustula; Henry G Zot; Nayef Mazloum; Marietta Y Lee; Daniel C Flynn
PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments.
Molecular biology of the cell 2002;13(7):2311-22.
2002: Lidia Cherezova; Amanda Gatesman; Daniel C Flynn
The effects of phosphorylation on adaptor protein function.
Frontiers in bioscience : a journal and virtual library 2002;7():d164-203.
2001: Joseph M Baisden; Amanda Gatesman; Lidia Cherezova; Bing-Hua Jiang; Daniel C Flynn
The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases.
Oncogene 2001;20(45):6607-16.
2001: Joseph M Baisden; Yong Qian; H M Zot; Daniel C Flynn
The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity.
Oncogene 2001;20(44):6435-47.
2001: Y Qian; Bing-Hua Jiang; Daniel C Flynn; Stephen S Leonard; S Wang; Z Zhang; J Ye; F Chen; L Wang; X Shi
Cr (VI) increases tyrosine phosphorylation through reactive oxygen species-mediated reactions.
Molecular and cellular biochemistry 2001;222(1-2):199-204.
2001: SJ Baker; R Sumerson; C Damodar Reddy; A S Berrebi; Daniel C Flynn; E Premkumar Reddy
Characterization of an alternatively spliced AATYK mRNA: expression pattern of AATYK in the brain and neuronal cells.
Oncogene 2001;20(9):1015-21.
2000: J G Hoey; Justin M Summy; Daniel C Flynn
Chimeric constructs containing the SH4/Unique domains of cYes can restrict the ability of Src(527F) to upregulate heme oxygenase-1 expression efficiently.
Cellular signalling 2000;12(9-10):691-701.
2000: Yong Qian; Joseph M Baisden; Henry G Zot; W B Van Winkle; Daniel C Flynn
The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation.
Experimental cell research 2000;255(1):102-13.
2000: Justin M Summy; AC Guappone; Marius Sudol; Daniel C Flynn
The SH3 and SH2 domains are capable of directing specificity in protein interactions between the non-receptor tyrosine kinases cSrc and cYes.
Oncogene 2000;19(1):155-60.
1999: Yong Qian; AC Guappone; Joseph M Baisden; M W Hill; Justin M Summy; Daniel C Flynn
Monoclonal antibodies directed against AFAP-110 recognize species-specific and conserved epitopes.
Hybridoma 1999;18(2):167-75.
1998: AC Guappone; T Weimer; Daniel C Flynn
Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif.
Molecular carcinogenesis 1998;22(2):110-9.
1998: Yong Qian; Joseph M Baisden; E H Westin; AC Guappone; T C Koay; Daniel C Flynn
Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity.
Oncogene 1998;16(17):2185-95.
1997: Xianglin Shi; Daniel C Flynn; K Liu; N Dalal
Vanadium (IV) formation in the reduction of vanadate by glutathione reductase/NADPH and the role of molecular oxygen.
Annals of clinical and laboratory science 1997;27(6):422-7.
1997: AC Guappone; Daniel C Flynn
The integrity of the SH3 binding motif of AFAP-110 is required to facilitate tyrosine phosphorylation by, and stable complex formation with, Src.
Molecular and cellular biochemistry 1997;175(1-2):243-52.
1997: Xianglin Shi; Daniel C Flynn; Dale W Porter; Stephen S Leonard; Val Vallyathan; Vincent Castranova
Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation.
Annals of clinical and laboratory science 1997;27(5):365-74.
1995: Daniel C Flynn; T C Koay; C G Humphries; AC Guappone
AFAP-120. A variant form of the Src SH2/SH3-binding partner AFAP-110 is detected in brain and contains a novel internal sequence which binds to a 67-kDa protein.
The Journal of biological chemistry 1995;270(8):3894-9.