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JoAnne Flynn

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Mohammad Fallahi-Sichani; JoAnne L Flynn; Jennifer J Linderman; Denise E Kirschner
Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability.
Hannah Priyadarshini Gideon; JoAnne L Flynn
Latent tuberculosis: what the host "sees"?
Christopher B Ford; Philana Ling Lin; Michael R Chase; Rupal R Shah; Oleg Iartchouk; James E Galagan; Nilofar Mohaideen; Thomas R Ioerger; James C Sacchettini; Marc Lipsitch; JoAnne L Flynn; Sarah Fortune
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection.

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All Publications

2012: Mohammad Fallahi-Sichani; JoAnne L Flynn; Jennifer J Linderman; Denise E Kirschner
Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(7):3169-78.
2011: Hannah Priyadarshini Gideon; JoAnne L Flynn
Latent tuberculosis: what the host "sees"?
Immunologic research 2011;50(2-3):202-12.
2011: Christopher B Ford; Philana Ling Lin; Michael R Chase; Rupal R Shah; Oleg Iartchouk; James E Galagan; Nilofar Mohaideen; Thomas R Ioerger; James C Sacchettini; Marc Lipsitch; JoAnne L Flynn; Sarah Fortune
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection.
Nature genetics 2011;43(5):482-6.
2011: Collin R Diedrich; JoAnne L Flynn
HIV-1/mycobacterium tuberculosis coinfection immunology: how does HIV-1 exacerbate tuberculosis?
Infection and immunity 2011;79(4):1407-17.
2011: Joshua T Mattila; Collin R Diedrich; Philana Ling Lin; Jiayao Phuah; JoAnne L Flynn
Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(6):3527-37.
2010: Simeone Marino; Amy Myers; JoAnne L Flynn; Denise E Kirschner
TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: a next-generation two-compartmental model.
Journal of theoretical biology 2010;265(4):586-98.
2010: Angela M Green; Joshua T Mattila; Carolyn L Bigbee; Kale S Bongers; Philana Ling Lin; JoAnne L Flynn
CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection.
The Journal of infectious diseases 2010;202(4):533-41.
2010: Philana Ling Lin; JoAnne L Flynn
Understanding latent tuberculosis: a moving target.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):15-22.
2010: Charles A Scanga; JoAnne L Flynn
Mycobacterial infections and the inflammatory seesaw.
Cell host & microbe 2010;7(3):177-9.
2010: Philana Ling Lin; Amy Myers; Le'Kneitah Smith; Carolyn Bigbee; Matthew Bigbee; Carl R Fuhrman; Heather Grieser; Ion Chiosea; Nikolai N Voitenek; Saverio V Capuano; Edwin Klein; JoAnne L Flynn
Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model.
Arthritis and rheumatism 2010;62(2):340-50.
2010: Collin R Diedrich; Joshua T Mattila; Edwin Klein; Chris Janssen; Jiayao Phuah; Timothy J Sturgeon; Ronald Montelaro; Philana Ling Lin; JoAnne L Flynn
Reactivation of latent tuberculosis in cynomolgus macaques infected with SIV is associated with early peripheral T cell depletion and not virus load.
PloS one 2010;5(3):e9611.
2009: Thorbjorg Einarsdottir; Euan Lockhart; JoAnne L Flynn
Cytotoxicity and secretion of gamma interferon are carried out by distinct CD8 T cells during Mycobacterium tuberculosis infection.
Infection and immunity 2009;77(10):4621-30.
2009: Philana Ling Lin; Mark Rodgers; Le'kneitah Smith; Matthew Bigbee; Amy Myers; Carolyn Bigbee; Ion Chiosea; Saverio V Capuano; Carl R Fuhrman; Edwin Klein; JoAnne L Flynn
Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model.
Infection and immunity 2009;77(10):4631-42.
2009: Hillarie Plessner Windish; P Ling Lin; Joshua T Mattila; Angela M Green; Ezenwa Obi Onuoha; Lawrence P Kane; JoAnne L Flynn
Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis.
Journal of leukocyte biology 2009;86(3):713-25.
2009: J Christian J Ray; JoAnne L Flynn; Denise E Kirschner
Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3706-17.
2008: Santosh N Pawar; Joshua T Mattila; Timothy J Sturgeon; Philana Ling Lin; Opendra Narayan; Ronald Montelaro; JoAnne L Flynn
Comparison of the effects of pathogenic simian human immunodeficiency virus strains SHIV-89.6P and SHIV-KU2 in cynomolgus macaques.
AIDS research and human retroviruses 2008;24(4):643-54.
2007: Simeone Marino; Dhruv Sud; Hillarie Plessner; Philana Ling Lin; John Chan; JoAnne L Flynn; Denise E Kirschner
Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue.
PLoS computational biology 2007;3(10):1909-24.
2007: Carolyn L Bigbee; Daryl G Gonchoroff; George Vratsanos; Steven G Nadler; Helen G Haggerty; JoAnne L Flynn
Abatacept treatment does not exacerbate chronic Mycobacterium tuberculosis infection in mice.
Arthritis and rheumatism 2007;56(8):2557-65.
2007: Hillarie L Plessner; Philana Ling Lin; Tadahiko Kohno; James S Louie; Denise E Kirschner; John Chan; JoAnne L Flynn
Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis.
The Journal of infectious diseases 2007;195(11):1643-50.
2007: Frank J Dann; Alice B Gottlieb; George S Deepe; JoAnne L Flynn; Robert Wallis; Elizabeth H Z Thompson; James S Louie
Structural-functional relationships of TNF-alpha antagonists: next steps.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2007;12(1):46-7.
2007: Philana Ling Lin; Hillarie L Plessner; Nikolai N Voitenok; JoAnne L Flynn
Tumor necrosis factor and tuberculosis.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2007;12(1):22-5.
2007: Amarendra Pegu; JoAnne L Flynn; Todd A Reinhart
Afferent and efferent interfaces of lymph nodes are distinguished by expression of lymphatic endothelial markers and chemokines.
Lymphatic research and biology 2007;5(2):91-103.
2006: Euan Lockhart; Angela M Green; JoAnne L Flynn
IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4662-9.
2006: Philana Ling Lin; Santosh Pawar; Amy Myers; Amarenda Pegu; Carl R Fuhrman; Todd A Reinhart; Saverio Capuano; Edwin Klein; JoAnne L Flynn
Early events in Mycobacterium tuberculosis infection in cynomolgus macaques.
Infection and immunity 2006;74(7):3790-803.
2006: Dhruv Sud; Carolyn Bigbee; JoAnne L Flynn; Denise E Kirschner
Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4296-314.
2006: JoAnne L Flynn
Lessons from experimental Mycobacterium tuberculosis infections.
Microbes and infection / Institut Pasteur 2006;8(4):1179-88.
2006: Penelope A Morel; Shlomo Ta'asan; Benoit F Morel; Denise E Kirschner; JoAnne L Flynn
New insights into mathematical modeling of the immune system.
Immunologic research 2006;36(1-3):157-65.
2005: Holly M Scott Algood; Philana Ling Lin; JoAnne L Flynn
Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41 Suppl 3():S189-93.
2005: Vanja Lazarevic; Dawn L Nolt; JoAnne L Flynn
Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):1107-17.
2005: Amy J Myers; Brandon Eilertson; Scott A Fulton; JoAnne L Flynn; David H Canaday
The purinergic P2X7 receptor is not required for control of pulmonary Mycobacterium tuberculosis infection.
Infection and immunity 2005;73(5):3192-5.
2005: Vanja Lazarevic; David J Yankura; Sherrie J DiVito; JoAnne L Flynn
Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice.
Infection and immunity 2005;73(5):2910-22.
2005: JoAnne L Flynn; John Chan
What's good for the host is good for the bug.
Trends in microbiology 2005;13(3):98-102.
2004: Holly M Scott Algood; JoAnne L Flynn
CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3287-96.
2004: Simeone Marino; Santosh Pawar; Craig L Fuller; Todd A Reinhart; JoAnne L Flynn; Denise E Kirschner
Dendritic cell trafficking and antigen presentation in the human immune response to Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):494-506.
2004: Holly M Scott Algood; Philana Ling Lin; David Yankura; Alvin Jones; John Chan; JoAnne L Flynn
TNF influences chemokine expression of macrophages in vitro and that of CD11b+ cells in vivo during Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(11):6846-57.
2004: Dawn L Nolt; JoAnne L Flynn
Interleukin-12 therapy reduces the number of immune cells and pathology in lungs of mice infected with Mycobacterium tuberculosis.
Infection and immunity 2004;72(5):2976-88.
2004: JoAnne L Flynn
Immunology of tuberculosis and implications in vaccine development.
Tuberculosis (Edinburgh, Scotland) 2004;84(1-2):93-101.
2003: Vanja Lazarevic; Amy J Myers; Charles A Scanga; JoAnne L Flynn
CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection.
Immunity 2003;19(6):823-35.
2003: Craig L Fuller; JoAnne L Flynn; Todd A Reinhart
In situ study of abundant expression of proinflammatory chemokines and cytokines in pulmonary granulomas that develop in cynomolgus macaques experimentally infected with Mycobacterium tuberculosis.
Infection and immunity 2003;71(12):7023-34.
2003: Holly M Scott Algood; John Chan; JoAnne L Flynn
Chemokines and tuberculosis.
Cytokine & growth factor reviews 2003;14(6):467-77.
2003: Saverio Capuano; Denise A Croix; Santosh Pawar; Angelica Zinovik; Amy Myers; Philana Ling Lin; Stephanie bissel; Carl R Fuhrman; Edwin Klein; JoAnne L Flynn
Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection.
Infection and immunity 2003;71(10):5831-44.
2003: JoAnne L Flynn; John Chan
Immune evasion by Mycobacterium tuberculosis: living with the enemy.
Current opinion in immunology 2003;15(4):450-5.
2003: Kathryn F Board; Sangita Patil; Irina P Lebedeva; Saverio Capuano; Anita M Trichel; Michael Murphey-Corb; Premeela A Rajakumar; JoAnne L Flynn; Constantine G Haidaris; Karen A Norris
Experimental Pneumocystis carinii pneumonia in simian immunodeficiency virus-infected rhesus macaques.
The Journal of infectious diseases 2003;187(4):576-88.
2003: JoAnne L Flynn; Saverio Capuano; Denise A Croix; Santosh Pawar; Amy Myers; A Zinovik; Edwin Klein
Non-human primates: a model for tuberculosis research.
Tuberculosis (Edinburgh, Scotland) 2003;83(1-3):116-8.
2002: Holly M Scott; JoAnne L Flynn
Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression.
Infection and immunity 2002;70(11):5946-54.
2002: Denise A Croix; Kathryn F Board; Saverio Capuano; Michael Murphey-Corb; Constantine G Haidaris; JoAnne L Flynn; Todd A Reinhart; Karen A Norris
Alterations in T lymphocyte profiles of bronchoalveolar lavage fluid from SIV- and Pneumocystis carinii-coinfected rhesus macaques.
AIDS research and human retroviruses 2002;18(5):391-401.
2001: NV Serbina; Vanja Lazarevic; JoAnne L Flynn
CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):6991-7000.
2001: Charles A Scanga; VP Mohan; Kathryn Tanaka; DAvid Alland; JoAnne L Flynn; John Chan
The inducible nitric oxide synthase locus confers protection against aerogenic challenge of both clinical and laboratory strains of Mycobacterium tuberculosis in mice.
Infection and immunity 2001;69(12):7711-7.
2001: NV Serbina; JoAnne L Flynn
CD8(+) T cells participate in the memory immune response to Mycobacterium tuberculosis.
Infection and immunity 2001;69(7):4320-8.
2001: JoAnne L Flynn; John Chan
Tuberculosis: latency and reactivation.
Infection and immunity 2001;69(7):4195-201.
2001: Taehoon Chun; NV Serbina; Dawn L Nolt; Bin Wang; NM Chiu; JoAnne L Flynn; Chyung-Ru Wang
Induction of M3-restricted cytotoxic T lymphocyte responses by N-formylated peptides derived from Mycobacterium tuberculosis.
The Journal of experimental medicine 2001;193(10):1213-20.
2001: Rhea N Coler; Antonio Campos-Neto; Pamela J Ovendale; F H Day; Steven P Fling; Li Zhu; NV Serbina; JoAnne L Flynn; Steven G Reed; Mark R Alderson
Vaccination with the T cell antigen Mtb 8.4 protects against challenge with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6227-35.
2001: VP Mohan; Charles A Scanga; K Yu; Holly M Scott; Kathryn Tanaka; E Tsang; M M Tsai; JoAnne L Flynn; John Chan
Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology.
Infection and immunity 2001;69(3):1847-55.
2001: K A Bodnar; NV Serbina; JoAnne L Flynn
Fate of Mycobacterium tuberculosis within murine dendritic cells.
Infection and immunity 2001;69(2):800-9.
2000: Denise A Croix; Saverio Capuano; L Simpson; Beth A Fallert; Craig L Fuller; EC Klein; Todd A Reinhart; Michael Murphey-Corb; JoAnne L Flynn
Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys.
AIDS research and human retroviruses 2000;16(17):1895-908.
2000: Charles A Scanga; VP Mohan; K Yu; H Joseph; Kathryn Tanaka; John Chan; JoAnne L Flynn
Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2.
The Journal of experimental medicine 2000;192(3):347-58.
2000: JoAnne L Flynn; Joel D Ernst
Immune responses in tuberculosis.
Current opinion in immunology 2000;12(4):432-6.
2000: NV Serbina; C C Liu; Charles A Scanga; JoAnne L Flynn
CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):353-63.
1999: Charles A Scanga; VP Mohan; H Joseph; K Yu; John Chan; JoAnne L Flynn
Reactivation of latent tuberculosis: variations on the Cornell murine model.
Infection and immunity 1999;67(9):4531-8.
1999: NV Serbina; JoAnne L Flynn
Early emergence of CD8(+) T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice.
Infection and immunity 1999;67(8):3980-8.
1999: A M Caruso; NV Serbina; E Klein; K Triebold; Barry R Bloom; JoAnne L Flynn
Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5407-16.
1998: JoAnne L Flynn; Charles A Scanga; Kathryn Tanaka; John Chan
Effects of aminoguanidine on latent murine tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1796-803.
1997: R A Henderson; simon simon watkins; JoAnne L Flynn
Activation of human dendritic cells following infection with Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):635-43.
1996: JoAnne L Flynn; Barry R Bloom
Role of T1 and T2 cytokines in the response to Mycobacterium tuberculosis.
Annals of the New York Academy of Sciences 1996;795():137-46.
1995: JoAnne L Flynn; M M Goldstein; K J Triebold; Joe Sypek; S Wolf; Barry R Bloom
IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2515-24.
1995: Karen A Norris; J E Schrimpf; JoAnne L Flynn; Sidney Morris
Enhancement of macrophage microbicidal activity: supplemental arginine and citrulline augment nitric oxide production in murine peritoneal macrophages and promote intracellular killing of Trypanosoma cruzi.
Infection and immunity 1995;63(7):2793-6.
1995: JoAnne L Flynn; M M Goldstein; John Chan; K J Triebold; K Pfeffer; Charles J Lowenstein; R Schreiber; T W Mak; Barry R Bloom
Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice.
Immunity 1995;2(6):561-72.
1994: JoAnne L Flynn
Recombinant BCG as an antigen delivery system.
Cellular and molecular biology (Noisy-le-Grand, France) 1994;40 Suppl 1():31-6.
1993: JoAnne L Flynn; John Chan; K J Triebold; Dyana Dalton; Timothy A Stewart; Barry R Bloom
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.
The Journal of experimental medicine 1993;178(6):2249-54.
1993: JoAnne L Flynn; M M Goldstein; K J Triebold; Barry R Bloom
Major histocompatibility complex class I-restricted T cells are necessary for protection against M. tuberculosis in mice.
Infectious agents and disease 1993;2(4):259-62.
1992: JoAnne L Flynn; M M Goldstein; K J Triebold; B Koller; Barry R Bloom
Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12013-7.
1990: JoAnne L Flynn; W R Weiss; Karen A Norris; H S Seifert; S Kumar; Magdalene So
Generation of a cytotoxic T-lymphocyte response using a Salmonella antigen-delivery system.
Molecular microbiology 1990;4(12):2111-8.