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Geoffrey Flynn

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
11
Hyndman, David
9
Wigle, Dennis
8
Jennings, DB
8
El-Kabbani, Ossama
5
Pang, Stephen
5
Delucas, Lawrence
4
Sonnenberg, H
4
Jia, Zongchao
3
Vera, NL
3
Veress, AT
3
Ye, Q
2
Tse, Yat
2
Rees-Milton, Karen
2
Shin, Seon
2
Melo, Luis

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Publications

TOP 3
Crosas Bernat; Hyndman David J; Gallego Oriol; Martras Sílvia; Parés Xavier; Flynn T Geoffrey; Farrés Jaume
Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.
Ye Q; Hyndman D; Green N; Li X; Korithoski B; Jia Z; Flynn T G
Crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding.
Tse M Y; Watson J D; Sarda I R; Flynn T G; Pang S C
Expression of B-type natriuretic peptide in atrial natriuretic peptide gene disrupted mice.

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All Publications

2003: Crosas Bernat; Hyndman David J; Gallego Oriol; Martras Sílvia; Parés Xavier; Flynn T Geoffrey; Farrés Jaume
Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism.
The Biochemical journal 2003;373(Pt 3):973-9.
2001: Ye Q; Hyndman D; Green N; Li X; Korithoski B; Jia Z; Flynn T G
Crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding.
Proteins 2001;44(1):12-9.
2001: Tse M Y; Watson J D; Sarda I R; Flynn T G; Pang S C
Expression of B-type natriuretic peptide in atrial natriuretic peptide gene disrupted mice.
Molecular and cellular biochemistry 2001;219(1-2):99-105.
2001: Ye Q; Hyndman D; Green N C; Li L; Jia Z; Flynn T G
The crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding.
Chemico-biological interactions 2001;130-132(1-3):651-8.
2000: Vera N; Tse M Y; Watson J D; Sarda S; Steinhelper M E; John S W; Flynn T G; Pang S C
Altered expression of natriuretic peptide receptors in proANP gene disrupted mice.
Cardiovascular research 2000;46(3):595-603.
2000: Ye Q; Hyndman D; Li X; Flynn T G; Jia Z
Crystal structure of CHO reductase, a member of the aldo-keto reductase superfamily.
Proteins 2000;38(1):41-8.
1999: Melo L G; Veress A T; Ackermann U; Pang S C; Flynn T G; Sonnenberg H
Chronic hypertension in ANP knockout mice: contribution of peripheral resistance.
Regulatory peptides 1999;79(2-3):109-15.
1999: Hyndman D; Flynn T G
The aldo-keto reductases and their role in cancer.
Advances in experimental medicine and biology 1999;463():427-34.
1998: Hyndman D J; Flynn T G
Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family.
Biochimica et biophysica acta 1998;1399(2-3):198-202.
1998: Rees-Milton K J; Jia Z; Green N C; Bhatia M; El-Kabbani O; Flynn T G
Aldehyde reductase: the role of C-terminal residues in defining substrate and cofactor specificities.
Archives of biochemistry and biophysics 1998;355(2):137-44.
1998: Melo L G; Veress A T; Chong C K; Pang S C; Flynn T G; Sonnenberg H
Salt-sensitive hypertension in ANP knockout mice: potential role of abnormal plasma renin activity.
The American journal of physiology 1998;274(1 Pt 2):R255-61.
1997: el-Kabbani O; Carper D A; McGowan M H; Devedjiev Y; Rees-Milton K J; Flynn T G
Studies on the inhibitor-binding site of porcine aldehyde reductase: crystal structure of the holoenzyme-inhibitor ternary complex.
Proteins 1997;29(2):186-92.
1997: Hyndman D J; Takenoshita R; Vera N L; Pang S C; Flynn T G
Cloning, sequencing, and enzymatic activity of an inducible aldo-keto reductase from Chinese hamster ovary cells.
The Journal of biological chemistry 1997;272(20):13286-91.
1997: Flynn T G; Hyndman D J; Takenoshita R; Vera N; Pang S
Cloning, sequencing, and enzymatic activity of an inducible aldo-keto reductase from Chinese hamster ovary cells.
Advances in experimental medicine and biology 1997;414():521-8.
1996: Flynn T G
Past and current perspectives on the natriuretic peptides.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1996;213(2):98-104.
1995: Wigle D A; Watson J D; Pang S C; Sarda I R; Roy R N; Flynn T G
Gene expression of A- and B-type natriuretic peptides in response to acute ethanol ingestion.
Alcoholism, clinical and experimental research 1995;19(5):1317-20.
1995: el-Kabbani O; Judge K; Ginell S L; Myles D A; DeLucas L J; Flynn T G
Structure of porcine aldehyde reductase holoenzyme.
Nature structural biology 1995;2(8):687-92.
1995: El-Kabbani O; Judge K; Ginell S L; DeLucas L J; Flynn T G
Crystallization and preliminary structure of porcine aldehyde reductase-NADPH binary complex.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 4):605-8.
1995: Kubiseski T J; Flynn T G
Studies on human aldose reductase. Probing the role of arginine 268 by site-directed mutagenesis.
The Journal of biological chemistry 1995;270(28):16911-7.
1995: Watson J D; Beckett-Jones B; Roy R N; Green N C; Flynn T G
Genomic sequence, structural organization and evolutionary conservation of the 13.2-kDa subunit of rat NADH:ubiquinone oxidoreductase.
Gene 1995;158(2):275-80.
1995: Wigle D A; Campling B G; Sarda I R; Shin S H; Watson J D; Frater Y; Flynn T G; Pang S C
ANP secretion from small cell lung cancer cell lines: a potential model of ANP release.
The American journal of physiology 1995;268(5 Pt 2):H1869-74.
1995: Feather M S; Flynn T G; Munro K A; Kubiseski T J; Walton D J
Catalysis of reduction of carbohydrate 2-oxoaldehydes (osones) by mammalian aldose reductase and aldehyde reductase.
Biochimica et biophysica acta 1995;1244(1):10-6.
1995: Campling B G; Sarda I R; Baer K A; Pang S C; Baker H M; Lofters W S; Flynn T G
Secretion of atrial natriuretic peptide and vasopressin by small cell lung cancer.
Cancer 1995;75(10):2442-51.
1995: Watson J D; Jennings D B; Sarda I R; Pang S C; Lawson B; Wigle D A; Flynn T G
The antidiuretic effect of pneumadin requires a functional arginine vasopressin system.
Regulatory peptides 1995;57(2):105-14.
1995: Flynn T G; Green N C; Bhatia M B; el-Kabbani O
Structure and mechanism of aldehyde reductase.
Advances in experimental medicine and biology 1995;372():193-201.
1994: El-Kabbani O; Green N C; Lin G; Carson M; Narayana S V; Moore K M; Flynn T G; DeLucas L J
Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 6):859-68.
1994: Weir M L; Honrath U; Flynn T G; Sonnenberg H
Lack of biologic activity or specific binding of amino-terminal pro-ANP segments in the rat.
Regulatory peptides 1994;53(2):111-22.
1994: Kubiseski T J; Green N C; Borhani D W; Flynn T G
Studies on pig aldose reductase. Identification of an essential arginine in the primary and tertiary structure of the enzyme.
The Journal of biological chemistry 1994;269(3):2183-8.
1993: El-Kabbani O; Sthanam L; Narayana V L; Moore K M; Green N C; Flynn T G; Delucas L J
Crystallization and preliminary structure determination of porcine aldehyde reductase from two crystal forms.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 5):490-6.
1993: Sarda I R; Wigle D A; Flynn T G; Pang S C
Radioimmunoassay for rat B-type natriuretic peptide (BNP-45).
Journal of immunoassay 1993;14(3):167-82.
1993: Weir M L; Pang S C; Flynn T G
Characterization of binding sites in rat for A, B and C-type natriuretic peptides.
Regulatory peptides 1993;47(3):291-305.
1993: Wigle D A; Pang S C; Watson J D; Sarda I R; Radakovic N N; Flynn T G
Chronic ethanol treatment increases the circulating plasma levels of B-type natriuretic peptide (BNP-45) in the rat.
American journal of hypertension 1993;6(8):719-22.
1993: Wigle D A; Pang S C; Radakovic N N; Sarda I R; Watson J D; Roy R N; Flynn T G
Chronic ethanol ingestion modifies the renin-aldosterone axis independent of alterations in the regulation of atrial natriuretic peptide.
Alcoholism, clinical and experimental research 1993;17(4):841-6.
1993: McKirdy J C; Ohtake P J; Flynn T G; Jennings D B
Circulatory and metabolic responses in awake dogs to infusion of iso-rANP/(rBNP).
Regulatory peptides 1993;47(1):41-51.
1993: Wigle D A; Pang S C; Sarda I R; Watson J D; Radakovic N N; Roy R; Flynn T G
Acute ethanol ingestion modifies the circulating plasma levels of atrial natriuretic peptide.
Alcohol (Fayetteville, N.Y.) 1993;10(4):275-80.
1993: Hira G K; Sarda I R; Wong S T; Pang S C; Flynn T G
Immunoactive iso-ANP/BNP in plasma, tissues and atrial granules of the rat.
Regulatory peptides 1993;44(1):1-9.
1993: Kubiseski T J; Green N C; Flynn T G
Location of an essential arginine residue in the primary structure of pig aldose reductase.
Advances in experimental medicine and biology 1993;328():259-65.
1993: Flynn T G; Green N C
The aldo-keto reductases: an overview.
Advances in experimental medicine and biology 1993;328():251-7.
1993: Flynn T G; Kubiseski T J
Chemical modification of an arginine residue in aldose reductase is enhanced by coenzyme binding: further evidence for conformational change during the reaction mechanism.
Advances in enzyme regulation 1993;33():197-206.
1993: Shin S H; Soukup C; Pang S C; Kubiseski T J; Flynn T G
Measurement of prolactin release and cytosolic calcium in estradiol-primed lactotrophs.
Life sciences 1993;53(21):1605-16.
1992: Wigle D A; Bennett B M; Jennings D B; Sarda I R; Flynn T G; Pang S C
Biological effects of rat iso-atrial natriuretic peptide and brain natriuretic peptide are indistinguishable from each other.
Canadian journal of physiology and pharmacology 1992;70(11):1525-8.
1992: Roy R N; Pang S C; Flynn T G
Expression of natriuretic peptide genes in cardiac tissues of hypertensive rats.
Molecular and cellular endocrinology 1992;86(1-2):R1-5.
1992: Kubiseski T J; Hyndman D J; Morjana N A; Flynn T G
Studies on pig muscle aldose reductase. Kinetic mechanism and evidence for a slow conformational change upon coenzyme binding.
The Journal of biological chemistry 1992;267(10):6510-7.
1991: el-Kabbani O; Narayana S V; Babu Y S; Moore K M; Flynn T G; Petrash J M; Westbrook E M; DeLucas L J; Bugg C E
Purification, crystallization and preliminary crystallographic analysis of porcine aldose reductase.
Journal of molecular biology 1991;218(4):695-8.
1991: Pang S C; Sarda I R; Wigle D A; Zhou Z J; Jennings D B; Flynn T G
Plasma clearance and tissue binding of rANP[99-126] and iso-rANP[1-45] in the rat.
Regulatory peptides 1991;33(1):1-9.
1990: Jennings D B; McKirdy J C; Ohtake P J; Sarda I R; Flynn T G; Hira G K
Infusion of iso-rANP(1-45) or (17-45) increases plasma immunoreactive ANP and lowers plasma renin activity and aldosterone.
Canadian journal of physiology and pharmacology 1990;68(9):1292-7.
1990: Roy R N; Flynn T G
Organization of the gene for iso-rANP, a rat B-type natriuretic peptide.
Biochemical and biophysical research communications 1990;171(1):416-23.
1990: Nishimura C; Matsuura Y; Kokai Y; Akera T; Carper D; Morjana N; Lyons C; Flynn T G
Cloning and expression of human aldose reductase.
The Journal of biological chemistry 1990;265(17):9788-92.
1990: Jennings D B; Flynn T G
The disulfide bonded ring of iso-rANP, unlike that of rANP, has potent cardiovascular activity.
Canadian journal of physiology and pharmacology 1990;68(1):131-6.
1990: Flynn T G; Lyons C; Hyndman D J
Enhancement of aldose reductase activity by modification of an active site lysine: a possible mechanism for in vivo activation.
Advances in enzyme regulation 1990;30():195-213.
1989: Jennings D B; Flynn T G
Cardiovascular and renal effects of iso-rANP, a second natriuretic peptide from rat atria.
Canadian journal of physiology and pharmacology 1989;67(10):1372-9.
1989: Flynn T G; Brar A; Tremblay L; Sarda I; Lyons C; Jennings D B
Isolation and characterization of iso-rANP, a new natriuretic peptide from rat atria.
Biochemical and biophysical research communications 1989;161(2):830-7.
1989: Morjana N A; Lyons C; Flynn T G
Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine.
The Journal of biological chemistry 1989;264(5):2912-9.
1989: Morjana N A; Flynn T G
Aldose reductase from human psoas muscle. Purification, substrate specificity, immunological characterization, and effect of drugs and inhibitors.
The Journal of biological chemistry 1989;264(5):2906-11.
1989: Flynn T G; Charington B; Lyons C; Chao H; Hyndman D; Morjana N
Chemical modification of aldehyde and aldose reductase by pyridoxal 5'-phosphate.
Progress in clinical and biological research 1989;290():251-64.
1988: Veress A T; Milojevic S; Yip C; Flynn T G; Sonnenberg H
In vitro secretion of atrial natriuretic factor: receptor-mediated release of prohormone.
The American journal of physiology 1988;254(5 Pt 2):R809-14.
1987: Flynn T G
The elucidation of the structure of atrial natriuretic factor, a new peptide hormone.
Canadian journal of physiology and pharmacology 1987;65(10):2013-20.

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