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Federico Focher

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Chemicals & Drugs

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Stefania Butini; Giuseppe Campiani; Marcella Facchini; Isabella Fiorini; Federico Focher; Sandra Gemma; Aristotele Karytinos; Andrea Lossani; Giuseppe Borrelli; Margherita Brindisi; Ettore Novellino; Alberta Samuele; Samantha Zanoli; giovanni maga
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
Stefania Butini; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Andrea Lossani; Anna Maria Ponte; Andrea Torti; giovanni maga; Luciana Marinelli; Valeria La Pietra; Isabella Fiorini; Stefania Lamponi; Giuseppe Campiani; Daniela M Zisterer; Seema-Maria Nathwani; Stefania Sartini; Concettina La Motta; Federico Da Settimo; Ettore Novellino; Federico Focher
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.
Bryan M Gebhardt; Federico Focher; Richard Eberle; Andrzej Manikowski; George E Wright
Effect of combinations of antiviral drugs on herpes simplex encephalitis.

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All Publications

2011: Stefania Butini; Giuseppe Campiani; Marcella Facchini; Isabella Fiorini; Federico Focher; Sandra Gemma; Aristotele Karytinos; Andrea Lossani; Giuseppe Borrelli; Margherita Brindisi; Ettore Novellino; Alberta Samuele; Samantha Zanoli; giovanni maga
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
Bioorganic & medicinal chemistry letters 2011;21(13):3935-8.
2011: Stefania Butini; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Andrea Lossani; Anna Maria Ponte; Andrea Torti; giovanni maga; Luciana Marinelli; Valeria La Pietra; Isabella Fiorini; Stefania Lamponi; Giuseppe Campiani; Daniela M Zisterer; Seema-Maria Nathwani; Stefania Sartini; Concettina La Motta; Federico Da Settimo; Ettore Novellino; Federico Focher
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.
Journal of medicinal chemistry 2011;54(5):1401-20.
2009: Bryan M Gebhardt; Federico Focher; Richard Eberle; Andrzej Manikowski; George E Wright
Effect of combinations of antiviral drugs on herpes simplex encephalitis.
Drug design, development and therapy 2009;3():289-94.
2007: Federico Focher; Andrea Lossani; Annalisa Verri; Silvio Spadari; Andrew Maioli; Joseph J Gambino; George E Wright; Richard Eberle; Darla H Black; Peter Medveczky; Maria Medveczky; David Shugar
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
Antimicrobial agents and chemotherapy 2007;51(6):2028-34.
2006: Teresa Semeraro; Andrea Lossani; Maurizio Botta; Chiara Ghiron; Reinaldo Alvarez; Fabrizio Manetti; Claudia Mugnaini; silvia valensin; Federico Focher; Federico Corelli
Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.
Journal of medicinal chemistry 2006;49(20):6037-45.
2006: Ombretta Turriziani; Paolo Pagnotti; Alessandra Pierangeli; Federico Focher; Cinzia Baranello; Francesca Bellomi; Francesca Falasca; Jessica Morgan; John D Schuetz; Guido Antonelli
The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.
AIDS research and human retroviruses 2006;22(10):960-7.
2005: Annalisa Verri; Federico Focher; Guido Tettamanti; Vittorio Grazioli
Two-step genetic screening of thrombophilia by pyrosequencing.
Clinical chemistry 2005;51(7):1282-4.
2005: Andrzej Manikowski; Annalisa Verri; Andrea Lossani; Bryan M Gebhardt; Joseph J Gambino; Federico Focher; Silvio Spadari; George E Wright
Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.
Journal of medicinal chemistry 2005;48(11):3919-29.
2004: Federico Corelli; Maurizio Botta; Andrea Lossani; Serena Pasquini; Silvio Spadari; Federico Focher
Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase.
Farmaco (Società chimica italiana : 1989) 2004;59(12):987-92.
2004: Béatrice Roy; Annalisa Verri; Andrea Lossani; Silvio Spadari; Federico Focher; Anne-Marie Aubertin; Gilles Gosselin; Christophe Mathé; Christian Périgaud
Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.
Biochemical pharmacology 2004;68(4):711-8.
2003: Lorenzo Magrassi; G Finocchiaro; Gabriele Milanesi; F Benvenuto; Silvio Spadari; Federico Focher
Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery.
Gene therapy 2003;10(25):2052-8.
2003: Stefano Manfredini; Nicola Solaroli; Angela Angusti; Federico Nalin; Elisa Durini; Silvia Vertuani; Pricl Sabrina; Marco Ferrone; Silvio Spadari; Federico Focher; Annalisa Verri; Erik De Clercq; Jan Balzarini
Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity.
Antiviral chemistry & chemotherapy 2003;14(4):183-94.
2003: Federico Focher; Silvio Spadari; giovanni maga
Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development.
Current drug targets. Infectious disorders 2003;3(1):41-53.
2003: Claudia Mugnaini; Maurizio Botta; Massimo Coletta; Federico Corelli; Federico Focher; Stefano Marini; Michela Lucia Renzulli; Annalisa Verri
Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides.
Bioorganic & medicinal chemistry 2003;11(3):357-66.
2003: Ombretta Turriziani; Carolina Scagnolari; Francesca Bellomi; Isabella Solimeo; Federico Focher; Guido Antonelli
Cellular issues relating to the resistance of HIV to antiretroviral agents.
Scandinavian journal of infectious diseases. Supplementum 2003;106():45-8.
2002: Ombretta Turriziani; John D Schuetz; Federico Focher; Carolina Scagnolari; Janardhan Sampath; Masashi Adachi; Federica Bambacioni; Elisabetta Riva; Guido Antonelli
Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11.
The Biochemical journal 2002;368(Pt 1):325-32.
2002: Ombretta Turriziani; Carolina Scagnolari; Federica Bambacioni; Francesca Bellomi; Federico Focher; Massimo Gentile; Guido Antonelli
Selection of a T-cell line resistant to stavudine and zidovudine by prolonged treatment with stavudine.
Antiviral therapy 2002;7(2):105-11.
2001: Federico Focher; Silvio Spadari
Thymidine phosphorylase: a two-face Janus in anticancer chemotherapy.
Current cancer drug targets 2001;1(2):141-53.
2001: Raul Salvetti; Arnaud Marchand; Massimo Pregnolato; Annalisa Verri; Silvio Spadari; Federico Focher; M Briant; Jean-Pierre Sommadossi; Christophe Mathé; Gilles Gosselin
5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations.
Bioorganic & medicinal chemistry 2001;9(7):1731-8.
2001: Raul Salvetti; Massimo Pregnolato; Annalisa Verri; Federico Focher; Silvio Spadari; Arnaud Marchand; Christophe Mathé; Gilles Gosselin
Synthesis and in vitro activity of D- and L-enantiomers of 5-(trifluoromethyl)uracil nucleoside derivatives.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1123-5.
2000: Annalisa Verri; Federico Focher; R J Duncombe; I Basnak; RT Walker; P L Coe; E de Clercq; G Andrei; R Snoeck; J Balzarini; Silvio Spadari
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes.
The Biochemical journal 2000;351 Pt 2():319-26.
2000: Federico Focher; Daniela Ubiali; Massimo Pregnolato; Chengxin Zhi; Joseph J Gambino; George E Wright; Silvio Spadari
Novel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis.
Journal of medicinal chemistry 2000;43(13):2601-7.
1999: H Sun; Chengxin Zhi; George E Wright; Daniela Ubiali; Massimo Pregnolato; Annalisa Verri; Federico Focher; Silvio Spadari
Molecular modeling and synthesis of inhibitors of herpes simplex virus type 1 uracil-DNA glycosylase.
Journal of medicinal chemistry 1999;42(13):2344-50.
1999: Annalisa Verri; Alessandra Montecucco; Gilles Gosselin; V Boudou; Silvio Spadari; Jean-Louis Imbach; Federico Focher
Interaction of beta-L-adenosine-5'-triphosphate (L-ATP) with human deoxycytidine kinase, human DNA primase and T4 DNA ligase: does the chance direct enzymatic enantioselectivity?
Nucleosides & nucleotides 1999;18(4-5):867-9.
1999: Massimo Pregnolato; Daniela Ubiali; Annalisa Verri; Federico Focher; Silvio Spadari; H Sun; Chengxin Zhi; George E Wright
Synthesis and molecular modeling of novel HSV1 uracil-DNA glycosylase inhibitors.
Nucleosides & nucleotides 1999;18(4-5):709-11.
1999: Annalisa Verri; Alessandra Montecucco; Gilles Gosselin; V Boudou; Jean-Louis Imbach; Silvio Spadari; Federico Focher
L-ATP is recognized by some cellular and viral enzymes: does chance drive enzymic enantioselectivity?
The Biochemical journal 1999;337 ( Pt 3)():585-90.
1998: S Strosselli; Silvio Spadari; RT Walker; I Basnak; Federico Focher
Trichomonas vaginalis thymidine kinase: purification, characterization and search for inhibitors.
The Biochemical journal 1998;334 ( Pt 1)():15-22.
1998: Silvio Spadari; giovanni maga; Annalisa Verri; Federico Focher
Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides.
Expert opinion on investigational drugs 1998;7(8):1285-300.
1998: I Basnak; M Sun; TA Hamor; Federico Focher; Annalisa Verri; Silvio Spadari; B Wroblowski; P Herdewijn; RT Walker
Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase.
Nucleosides & nucleotides 1998;17(1-3):187-206.
1997: Annalisa Verri; G Priori; Silvio Spadari; L Tondelli; Federico Focher
Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.
The Biochemical journal 1997;328 ( Pt 1)():317-20.
1997: Annalisa Verri; Federico Focher; G Priori; Gilles Gosselin; Jean-Louis Imbach; Massimo L Capobianco; A Garbesi; Silvio Spadari
Lack of enantiospecificity of human 2'-deoxycytidine kinase: relevance for the activation of beta-L-deoxycytidine analogs as antineoplastic and antiviral agents.
Molecular pharmacology 1997;51(1):132-8.
1995: Federico Focher; giovanni maga; A Bendiscioli; M Capobianco; F Colonna; A Garbesi; Silvio Spadari
Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate.
Nucleic acids research 1995;23(15):2840-7.
1995: Rafaela Argnani; Federico Focher; Silvia Zucchini; Annalisa Verri; George E Wright; Silvio Spadari; Roberto Manservigi
Herpes simplex virus type 1 (HSV-1) uracil-DNA glycosylase: functional expression in Escherichia coli, biochemical characterization, and selective inhibition by 6-(p-n-octylanilino)uracil.
Virology 1995;211(1):307-11.
1995: Silvio Spadari; G Ciarrocchi; Federico Focher; Annalisa Verri; giovanni maga; FM Arcamone; Elisabetta Iafrate; Stefano Manzini; A Garbesi; L Tondelli
5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies.
Molecular pharmacology 1995;47(6):1231-8.
1995: Alessandra Montecucco; E Savini; Giuseppe Biamonti; M Stefanini; Federico Focher; G Ciarrocchi
Late induction of human DNA ligase I after UV-C irradiation.
Nucleic acids research 1995;23(6):962-6.
1995: H Xu; giovanni maga; Federico Focher; E R Smith; Silvio Spadari; J Gambino; George E Wright
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
Journal of medicinal chemistry 1995;38(1):49-57.
1995: Silvio Spadari; giovanni maga; Annalisa Verri; A Bendiscioli; L Tondelli; M Capobianco; F Colonna; A Garbesi; Federico Focher
Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.
Biochimie 1995;77(11):861-67.
1994: Annalisa Verri; giovanni maga; Silvio Spadari; Wilma Ponti; S Strosselli; L Bonizzi; Mara Rocchi; G Poli; Federico Focher
Aphidicolin inhibits in vitro the activity of pseudorabies virus (PRV) DNA polymerase and in vivo the viral proliferation.
In vivo (Athens, Greece) 1994;8(6):1041-6.
1994: giovanni maga; Federico Focher; George E Wright; M Capobianco; A Garbesi; A Bendiscioli; Silvio Spadari
Kinetic studies with N2-phenylguanines and with L-thymidine indicate that herpes simplex virus type-1 thymidine kinase and thymidylate kinase share a common active site.
The Biochemical journal 1994;302 ( Pt 1)():279-82.
1994: George E Wright; U Hübscher; N N Khan; Federico Focher; A Verri
Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon.
FEBS letters 1994;341(1):128-30.
1994: giovanni maga; Silvio Spadari; George E Wright; Federico Focher
Identification, partial purification and inhibition by guanine analogues of a novel enzymic activity which phosphorylates guanosine to GMP in the protozoan parasite Eimeria tenella.
The Biochemical journal 1994;298 ( Pt 2)():289-94.
1993: Giovanni Piccolo; Federico Focher; Annalisa Verri; Silvio Spadari; P Banfi; E Gerosa; P Mazzarello
Myoclonus epilepsy and ragged-red fibers: blood mitochondrial DNA heteroplasmy in affected and asymptomatic members of a family.
Acta neurologica Scandinavica 1993;88(6):406-9.
1993: giovanni maga; Annalisa Verri; L Bonizzi; Wilma Ponti; G Poli; A Garbesi; D Niccolai; Silvio Spadari; Federico Focher
Lack of stereospecificity of suid pseudorabies virus thymidine kinase.
The Biochemical journal 1993;294 ( Pt 2)():381-5.
1993: Federico Focher; Annalisa Verri; Silvio Spadari; Roberto Manservigi; J Gambino; George E Wright
Herpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives.
The Biochemical journal 1993;292 ( Pt 3)():883-9.
1992: Alessandra Montecucco; Giuseppe Biamonti; E Savini; Federico Focher; Silvio Spadari; G Ciarrocchi
DNA ligase I gene expression during differentiation and cell proliferation.
Nucleic acids research 1992;20(23):6209-14.
1992: P Mazzarello; Annalisa Verri; Chiara Mondello; S Colombo; giovanni maga; Silvio Spadari; Federico Focher
Enzymes of DNA metabolism in a patient with the Wiedemann-Rautenstrauch progeroid syndrome.
Annals of the New York Academy of Sciences 1992;663():440-1.
1992: Annalisa Verri; P Mazzarello; Silvio Spadari; Federico Focher
Uracil-DNA glycosylases preferentially excise mispaired uracil.
The Biochemical journal 1992;287 ( Pt 3)():1007-10.
1992: Silvio Spadari; giovanni maga; Federico Focher; G Ciarrocchi; Roberto Manservigi; FM Arcamone; M Capobianco; A Carcuro; F Colonna; S Iotti
L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth.
Journal of medicinal chemistry 1992;35(22):4214-20.
1992: P Mazzarello; Marco Poloni; S Spadari; Federico Focher
DNA repair mechanisms in neurological diseases: facts and hypotheses.
Journal of the neurological sciences 1992;112(1-2):4-14.
1992: J Gambino; Federico Focher; C Hildebrand; giovanni maga; T Noonan; Silvio Spadari; G Wright
Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
Journal of medicinal chemistry 1992;35(16):2979-83.
1992: Annalisa Verri; S Verzeletti; P Mazzarello; Silvio Spadari; M Negri; G Bunone; G Della Valle; Ulrich Hübscher; Federico Focher
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
Anticancer research 1992;12(4):1099-105.
1992: Federico Focher; Annalisa Verri; S Verzeletti; P Mazzarello; Silvio Spadari
Uracil in OriS of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?
Chromosoma 1992;102(1 Suppl):S67-71.
1991: Alessandra Montecucco; M Fontana; Federico Focher; M Lestingi; Silvio Spadari; G Ciarrocchi
Specific inhibition of human DNA ligase adenylation by a distamycin derivative possessing antitumor activity.
Nucleic acids research 1991;19(5):1067-72.
1990: Annalisa Verri; P Mazzarello; Giuseppe Biamonti; Silvio Spadari; Federico Focher
The specific binding of nuclear protein(s) to the cAMP responsive element (CRE) sequence (TGACGTCA) is reduced by the misincorporation of U and increased by the deamination of C.
Nucleic acids research 1990;18(19):5775-80.
1990: Federico Focher; P Mazzarello; Annalisa Verri; Ulrich Hübscher; Silvio Spadari
Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development.
Mutation research 1990;237(2):65-73.
1990: P Mazzarello; Federico Focher; Annalisa Verri; Silvio Spadari
Misincorporation of uracil into DNA as possible contributor to neuronal aging and abiotrophy.
The International journal of neuroscience 1990;50(3-4):169-74.
1990: C Hildebrand; D Sandoli; Federico Focher; J Gambino; G Ciarrocchi; Silvio Spadari; G Wright
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
Journal of medicinal chemistry 1990;33(1):203-6.
1990: Federico Focher; Annalisa Verri; giovanni maga; Silvio Spadari; Ulrich Hübscher
Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease.
FEBS letters 1990;259(2):349-52.
1989: Federico Focher; D Sandoli; C Hildebrand; S Sangalli; G Ciarrocchi; A Rebuzzini; G Pedrali-Noy; Roberto Manservigi; G Wright; N Brown
Nucleoside analogs as non-substrate inhibitors of herpes simplex viruses thymidine kinase.
Methods and findings in experimental and clinical pharmacology 1989;11(9):577-82.
1989: Federico Focher; D Sandoli; G Wright; S Sangalli; G Ciarrocchi; G Pedrali-Noy; A Rebuzzini; N Brown; Silvio Spadari
A novel pharmacological approach to herpes virus infections.
Journal of chemotherapy (Florence, Italy) 1989;1(4 Suppl):1107-8.
1989: Silvio Spadari; Alessandra Montecucco; G Pedrali-Noy; G Ciarrocchi; Federico Focher; Ulrich Hübscher
A double-loop model for the replication of eukaryotic DNA.
Mutation research 1989;219(3):147-56.
1988: Federico Focher; C Hildebrand; S Freese; G Ciarrocchi; T Noonan; S Sangalli; N Brown; Silvio Spadari; G Wright
N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.
Journal of medicinal chemistry 1988;31(8):1496-500.
1988: Alessandra Montecucco; Silvio Spadari; Federico Focher; G Pedrali-Noy; C Sala; G Palù; G Ciarrocchi
Detection of the effects of intercalating and non-intercalating drugs on DNA structure.
Biochemical pharmacology 1988;37(9):1853-4.
1988: Federico Focher; S Sangalli; G Ciarrocchi; G Della Valle; D Talarico; A Rebuzzini; G Wright; N Brown; Silvio Spadari
N2-substituted guanine derivatives act as selective non substrate inhibitors of HSV I thymidine kinase.
Biochemical pharmacology 1988;37(9):1877-8.
1987: Silvio Spadari; B M Sutherland; G Pedrali-Noy; Federico Focher; M T Chiesa; G Ciarrocchi
Alteration of DNA tertiary structure by physical and chemical carcinogens: involvement in DNA repair processes.
Toxicologic pathology 1987;15(1):82-7.
1986: Silvio Spadari; Federico Focher; S Sangalli; U Hübscher
The effect of drugs on mitochondrial DNA synthesis can be tested in isolated synaptosomes.
Nucleic acids research 1986;14(23):9523-4.
1986: Silvio Spadari; G Pedrali-Noy; Federico Focher; Alessandra Montecucco; T Bordoni; Cristina Geroni; FC Giuliani; G Ventrella; FM Arcamone; G Ciarrocchi
DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs.
Anticancer research 1986;6(5):935-40.
1985: Silvio Spadari; Federico Focher; C Kuenzle; E J Corey; A G Myers; N Hardt; A Rebuzzini; G Ciarrocchi; G Pedrali-Noy
In vivo distribution and activity of aphidicolin on dividing and quiescent cells.
Antiviral research 1985;5(2):93-101.
1985: Silvio Spadari; Federico Focher; F Sala; G Ciarrocchi; G Koch; A Falaschi; G Pedrali-Noy
Control of cell division by aphidicolin without adverse effects upon resting cells.
Arzneimittel-Forschung 1985;35(7):1108-16.
1982: G Pedrali-Noy; M Belvedere; crepaldi tiziana; Federico Focher; Silvio Spadari
Inhibition of DNA replication and growth of several human and murine neoplastic cells by aphidicolin without detectable effect upon synthesis of immunoglobulins and HLA antigens.
Cancer research 1982;42(9):3810-3.
1981: N Hardt; G Pedrali-Noy; Federico Focher; Silvio Spadari
Aphidicolin does not inhibit DNA repair synthesis in ultraviolet-irradiated HeLa cells. A radioautographic study.
The Biochemical journal 1981;199(2):453-5.
1981: G Pedrali-Noy; C C Kuenzle; Federico Focher; M Belvedere; Silvio Spadari
An enzymatic method for microdetermination of aphidicolin: a promising anticancer drug.
Journal of biochemical and biophysical methods 1981;4(2):113-21.
1980: G Pedrali-Noy; G Mazza; Federico Focher; Silvio Spadari
Lack of mutagenicity and metabolic inactivation of aphidicolin by rat liver microsomes.
Biochemical and biophysical research communications 1980;93(4):1094-103.