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Tung Fong

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Alison M Strack; Donald Thompson; Joana Achanfuo-Yeboah; Paul K Cunningham; TD Faidley; Tung M Fong; Gerry Hickey; Donald Hora; Amy O Johnson-Levonas; Susan Nicolich; Steven B Heymsfield
Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss.
Qingmei Hong; Raman K Bakshi; Brenda L Palucki; Min K Park; Zhixiong Ye; Shuwen He; Patrick G Pollard; Iyassu K Sebhat; Jian Liu; Liangqin Guo; Doreen E Cashen; William J Martin; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Alison M Strack; Tung M Fong; D Euan MacIntyre; Matthew J Wyvratt; Ravi P Nargund
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
Gregory M Dillon; Laura S Lubbers; Mitchell T Ferguson; Julie Lao; Ruey-Ruey C Huang; Jing C Xiao; Tung M Fong; Jeffrey J Hale; Kathleen Rupprecht; Shouwu Miao; Blake A Rowe; Thomas J Kornecook; Jean-Cosme Dodart
MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice.

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All Publications

2012: Alison M Strack; Donald Thompson; Joana Achanfuo-Yeboah; Paul K Cunningham; TD Faidley; Tung M Fong; Gerry Hickey; Donald Hora; Amy O Johnson-Levonas; Susan Nicolich; Steven B Heymsfield
Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss.
Metabolism: clinical and experimental 2012;61(4):546-53.
2011: Qingmei Hong; Raman K Bakshi; Brenda L Palucki; Min K Park; Zhixiong Ye; Shuwen He; Patrick G Pollard; Iyassu K Sebhat; Jian Liu; Liangqin Guo; Doreen E Cashen; William J Martin; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Alison M Strack; Tung M Fong; D Euan MacIntyre; Matthew J Wyvratt; Ravi P Nargund
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
Bioorganic & medicinal chemistry letters 2011;21(8):2330-4.
2011: Gregory M Dillon; Laura S Lubbers; Mitchell T Ferguson; Julie Lao; Ruey-Ruey C Huang; Jing C Xiao; Tung M Fong; Jeffrey J Hale; Kathleen Rupprecht; Shouwu Miao; Blake A Rowe; Thomas J Kornecook; Jean-Cosme Dodart
MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice.
Behavioural pharmacology 2011;22(2):91-100.
2010: Shuwen He; Zhixiong Ye; Peter H Dobbelaar; Raman K Bakshi; Qingmei Hong; James P Dellureficio; Iyassu K Sebhat; Liangqin Guo; Jian Liu; Tianying Jian; Yingjie Lai; Christopher L Franklin; Mikhail Reibarkh; Mark A Holmes; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Alison M Strack; Tung M Fong; Matthew J Wyvratt; Ravi P Nargund
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Bioorganic & medicinal chemistry letters 2010;20(22):6524-32.
2010: Wenqing Zhao; Olivia Fong; Eric S Muise; John R Thompson; Drew Weingarth; Su Qian; Tung M Fong
Genome-wide expression profiling revealed peripheral effects of cannabinoid receptor 1 inverse agonists in improving insulin sensitivity and metabolic parameters.
Molecular pharmacology 2010;78(3):350-9.
2010: Ihor Kopka; Linus S Lin; James P Jewell; Thomas J Lanza; Tung M Fong; Chun-Pyn Shen; Zhege J Lao; Sookhee Ha; Laurie G Castonguay; Lex Van der Ploeg; Mark T Goulet; William K Hagmann
Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.
Bioorganic & medicinal chemistry letters 2010;20(16):4757-61.
2010: Liangqin Guo; Zhixiong Ye; Jian Liu; Shuwen He; Raman K Bakshi; Iyassu K Sebhat; Peter H Dobbelaar; Qingmei Hong; Tianying Jian; James P Dellureficio; Nancy N Tsou; Richard G Ball; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Howard Y Chen; Airu S Chen; William J Martin; D Euan MacIntyre; Alison M Strack; Tung M Fong; Matthew J Wyvratt; Ravi P Nargund
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Bioorganic & medicinal chemistry letters 2010;20(16):4895-900.
2010: Shuwen He; Zhixiong Ye; Peter H Dobbelaar; Iyassu K Sebhat; Liangqin Guo; Jian Liu; Tianying Jian; Yingjie Lai; Christopher L Franklin; Raman K Bakshi; James P Dellureficio; Qingmei Hong; David Weinberg; Tanya MacNeil; Rui Tang; Alison M Strack; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Tung M Fong; Matthew J Wyvratt; Ravi P Nargund
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Bioorganic & medicinal chemistry letters 2010;20(15):4399-405.
2010: Christina B Madsen-Duggan; John S Debenham; Thomas F Walsh; Lin Yan; Pei Huo; Junying Wang; Xinchun Tong; Julie Lao; Tung M Fong; Jing Chen Xiao; Cathy R-R C Huang; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Mark T Goulet; Jeffrey J Hale
Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.
Bioorganic & medicinal chemistry letters 2010;20(12):3750-4.
2010: Lin Yan; Pei Huo; John S Debenham; Christina B Madsen-Duggan; Julie Lao; Richard Z Chen; Jing Chen Xiao; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Nancy N Tsou; Richard G Ball; Junying Wang; Xinchun Tong; Thomas J Bateman; Vijay B G Reddy; Tung M Fong; Jeffrey J Hale
Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.
Journal of medicinal chemistry 2010;53(10):4028-37.
2010: Shuwen He; Zhixiong Ye; Peter H Dobbelaar; Iyassu K Sebhat; Liangqin Guo; Jian Liu; Tianying Jian; Yingjie Lai; Christopher L Franklin; Raman K Bakshi; James P Dellureficio; Qingmei Hong; Nancy N Tsou; Richard G Ball; Doreen E Cashen; William J Martin; David Weinberg; Tanya MacNeil; Rui Tang; Constantin Tamvakopoulos; Qianping Peng; Randy R Miller; Ralph A Stearns; Howard Y Chen; Airu S Chen; Alison M Strack; Tung M Fong; D Euan MacIntyre; Matthew J Wyvratt; Ravi P Nargund
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Bioorganic & medicinal chemistry letters 2010;20(7):2106-10.
2010: John S Debenham; Christina B Madsen-Duggan; Richard B Toupence; Thomas F Walsh; Junying Wang; Xinchun Tong; Sanjeev Kumar; Julie Lao; Tung M Fong; Jing Chen Xiao; Cathy R-R C Huang; Chun-Pyn Shen; Yue Feng; Donald J Marsh; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Mark T Goulet
Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.
Bioorganic & medicinal chemistry letters 2010;20(4):1448-52.
2010: Tung M Fong
Measurement of inverse agonism of the cannabinoid receptors.
Methods in enzymology 2010;485():139-45.
2009: Wu Du; James P Jewell; Linus S Lin; Vincent J Colandrea; Jing Chen Xiao; Julie Lao; Chun-Pyn Shen; Thomas J Bateman; Vijay B G Reddy; Sookhee N Ha; Shrenik K Shah; Tung M Fong; Jeffrey J Hale; William K Hagmann
Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.
Bioorganic & medicinal chemistry letters 2009;19(17):5195-9.
2009: Tung M Fong; Steven B Heymsfield
Cannabinoid-1 receptor inverse agonists: current understanding of mechanism of action and unanswered questions.
International journal of obesity (2005) 2009;33(9):947-55.
2009: Terence G Hamill; Linus S Lin; William K Hagmann; Ping Liu; James P Jewell; Sandra Sanabria; Waisi Eng; Christine Ryan; Tung M Fong; Brett Connolly; Amy Vanko; Richard Hargreaves; Mark T Goulet; H Donald Burns
PET imaging studies in rhesus monkey with the cannabinoid-1 (CB1) receptor ligand [11C]CB-119.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2009;11(4):246-52.
2009: John S Debenham; Christina B Madsen-Duggan; Junying Wang; Xinchun Tong; Julie Lao; Tung M Fong; Marie-Therese Schaeffer; Jing Chen Xiao; Cathy C R-R Huang; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; D Euan Macintyre; Jeffrey J Hale; Thomas F Walsh
Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2009;19(9):2591-4.
2009: Petr Vachal; Joan M Fletcher; Tung M Fong; Cathy C R-R Huang; Julie Lao; Jing Chen Xiao; Chun-Pyn Shen; Alison M Strack; Lauren P Shearman; Sloan Stribling; Richard Z Chen; Andrea Frassetto; Xinchun Tong; Junying Wang; Richard G Ball; Nancy N Tsou; Gerard J Hickey; Donald Thompson; TD Faidley; Susan Nicolich; Joana Achanfuo-Yeboah; Donald F Hora; Jeffrey J Hale; William K Hagmann
1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.
Journal of medicinal chemistry 2009;52(8):2550-8.
2008: Jing Chen Xiao; James P Jewell; Linus S Lin; William K Hagmann; Tung M Fong; Chun-Pyn Shen
Similar in vitro pharmacology of human cannabinoid CB1 receptor variants expressed in CHO cells.
Brain research 2008;1238():36-43.
2008: Andrea Frassetto; Jiaping Zhang; Julie Z Lao; Amanda White; Joseph M Metzger; Tung M Fong; Richard Z Chen
Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor.
Brain research 2008;1236():140-4.
2008: Maria A Bednarek; Tanya MacNeil; Rui Tang; Tung M Fong; M Angeles Cabello; Marta Maroto; Ana Teran
Cyclic analogs of alpha-melanocyte-stimulating hormone (alphaMSH) with high agonist potency and selectivity at human melanocortin receptor 1b.
Peptides 2008;29(6):1010-7.
2008: Maria A Bednarek; Tanya MacNeil; Rui Tang; Tung M Fong; M Angeles Cabello; Marta Maroto; Ana Teran
Analogs of alpha-melanocyte stimulating hormone with high agonist potency and selectivity at human melanocortin receptor 1b: the role of Trp(9) in molecular recognition.
Biopolymers 2008;89(5):401-8.
2008: Richard Z Chen; Andrea Frassetto; Julie Lao; Ruey-Ruey C Huang; Jing Chen Xiao; Matthew J Clements; Thomas F Walsh; Jeffrey J Hale; Junying Wang; Xinchun Tong; Tung M Fong
Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor.
European journal of pharmacology 2008;584(2-3):338-42.
2008: Linus S Lin; Sookhee Ha; Richard G Ball; Nancy N Tsou; Laurie A Castonguay; George A Doss; Tung M Fong; Chun-Pyn Shen; Jing Chen Xiao; Mark T Goulet; William K Hagmann
Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.
Journal of medicinal chemistry 2008;51(7):2108-14.
2008: Tung M Fong
Development of anti-obesity agents: drugs that target neuropeptide and neurotransmitter systems.
Expert opinion on investigational drugs 2008;17(3):321-5.
2008: Joseph P Tizzano; D Sloan Stribling; Diego Perez-Tilve; Alison M Strack; Andrea Frassetto; Richard Z Chen; Tung M Fong; Lauren P Shearman; Philip Krieter; Matthias H Tschöp; Phil Skolnick; Anthony Basile
The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1111-26.
2008: Joanna P Tyszkiewicz; Tung M Fong; Yan Dong
GABAB receptors are required for galanin modulation of membrane properties of neurons in the arcuate nucleus of rats.
Brain research 2008;1191():63-8.
2008: Lauren P Shearman; D Sloan Stribling; Ramon E Camacho; Kimberly Rosko; Junying Wang; Sharon Tong; Yue Feng; Donald J Marsh; Hong Yu; Xiaoming Guan; Stephanie K Spann; Douglas J MacNeil; Tung M Fong; Joseph M Metzger; Mark T Goulet; William K Hagmann; Christopher W Plummer; Paul E Finke; Sander G Mills; Shrenik K Shah; Quang Truong; Lex H T Van Der Ploeg; D Euan MacIntyre; Alison M Strack
Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.
European journal of pharmacology 2008;579(1-3):215-24.
2008: Steven B Heymsfield; Allison Martin-Nguyen; Tung M Fong; Dympna Gallagher; Angelo Pietrobelli
Body circumferences: clinical implications emerging from a new geometric model.
Nutrition & metabolism 2008;5():24.
2007: Iyassu K Sebhat; Yingjie Lai; Khaled Barakat; Zhixiong Ye; Rui Tang; Rubana N Kalyani; Aurawan Vongs; Tanya MacNeil; David Weinberg; M Angeles Cabello; Marta Maroto; Ana Teran; Tung M Fong; Lex H T Van Der Ploeg; Arthur A Patchett; Ravi P Nargund
Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.
Bioorganic & medicinal chemistry letters 2007;17(20):5720-3.
2007: Ping Liu; Linus S Lin; Terence G Hamill; James P Jewell; Thomas J Lanza; Raymond E Gibson; Stephen M Krause; Christine Ryan; Waisi Eng; Sandra Sanabria; Xinchun Tong; Junying Wang; Dorothy A Levorse; Karen Owens; Tung M Fong; Chun-Pyn Shen; Julie Lao; Sanjeev Kumar; Wenji Yin; Joseph F Payack; Shawn A Springfield; Richard Hargreaves; H Donald Burns; Mark T Goulet; William K Hagmann
Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.
Journal of medicinal chemistry 2007;50(15):3427-30.
2007: H Donald Burns; Koen Van Laere; Sandra Sanabria; Terence G Hamill; Guy Bormans; Waisi Eng; Ray Gibson; Christine Ryan; Brett Connolly; Shil Patel; Stephen Krause; Amy Vanko; Anne Van Hecken; Patrick Dupont; Inge De Lepeleire; Paul L Rothenberg; S Aubrey Stoch; Josee Cote; William K Hagmann; James P Jewell; Linus S Lin; Ping Liu; Mark T Goulet; Keith M Gottesdiener; John A Wagner; Jan de Hoon; Luc Mortelmans; Tung M Fong; Richard Hargreaves
[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9800-5.
2007: Tung M Fong; Xiao-Ming Guan; Donald J Marsh; Chun-Pyn Shen; D Sloan Stribling; Kimberly Rosko; Julie Lao; Hong Yu; Yue Feng; Jing Chen Xiao; Lex H T Van Der Ploeg; Mark T Goulet; William K Hagmann; Linus S Lin; Thomas J Lanza; James P Jewell; Ping Liu; Shrenik K Shah; Hongbo Qi; Xinchun Tong; Junying Wang; Suoyu S Xu; Barbara Francis; Alison M Strack; D Euan MacIntyre; Lauren P Shearman
Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1013-22.
2007: Maria A Bednarek; Tanya MacNeil; Rui Tang; Tung M Fong; M Angeles Cabello; Marta Maroto; Ana Teran
Potent and selective agonists of human melanocortin receptor 5: cyclic analogues of alpha-melanocyte-stimulating hormone.
Journal of medicinal chemistry 2007;50(10):2520-6.
2007: Maria A Bednarek; Tanya MacNeil; Rui Tang; Tung M Fong; M Angeles Cabello; Marta Maroto; Ana Teran
Potent and selective peptide agonists of alpha-melanocyte stimulating hormone (alphaMSH) action at human melanocortin receptor 5; their synthesis and biological evaluation in vitro.
Chemical biology & drug design 2007;69(5):350-5.
2007: Maria A Bednarek; Tanya MacNeil; Rui Tang; Tung M Fong; M Angeles Cabello; Marta Maroto; Ana Teran
Potent and selective agonists of alpha-melanotropin (alphaMSH) action at human melanocortin receptor 5; linear analogs of alpha-melanotropin.
Peptides 2007;28(5):1020-8.
2007: Helen E Armstrong; Amy Galka; Linus S Lin; Thomas J Lanza; James P Jewell; Shrenik K Shah; Ravindra N Guthikonda; Quang Truong; Linda L Chang; Grace Quaker; Vincent J Colandrea; Xinchun Tong; Junying Wang; Sherry Xu; Tung M Fong; Chun-Pyn Shen; Julie Lao; Jing Chen; Lauren P Shearman; D Sloan Stribling; Kimberly Rosko; Alison M Strack; Sookhee Ha; Lex H T Van Der Ploeg; Mark T Goulet; William K Hagmann
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.
Bioorganic & medicinal chemistry letters 2007;17(8):2184-7.
2007: Christina B Madsen-Duggan; John S Debenham; Thomas F Walsh; Richard B Toupence; Song X Huang; Junying Wang; Xinchun Tong; Julie Lao; Tung M Fong; Marie-Therese Schaeffer; Jing Chen Xiao; Cathy R-R C Huang; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; D Euan MacIntyre; Lex H T Van Der Ploeg; Mark T Goulet
Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists.
Bioorganic & medicinal chemistry letters 2007;17(7):2031-5.
2006: Linus S Lin; Thomas J Lanza; James P Jewell; Ping Liu; Shrenik K Shah; Hongbo Qi; Xinchun Tong; Junying Wang; Suoyu S Xu; Tung M Fong; Chun-Pyn Shen; Julie Lao; Jing Chen Xiao; Lauren P Shearman; D Sloan Stribling; Kimberly Rosko; Alison M Strack; Donald J Marsh; Yue Feng; Sanjeev Kumar; Koppara Samuel; Wenji Yin; Lex H T Van Der Ploeg; Mark T Goulet; William K Hagmann
Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.
Journal of medicinal chemistry 2006;49(26):7584-7.
2006: Louise E Johnstone; Tung M Fong; Gareth Leng
Neuronal activation in the hypothalamus and brainstem during feeding in rats.
Cell metabolism 2006;4(4):313-21.
2006: Jiaping Zhang; Andrea Frassetto; Ruey-Ruey C Huang; Julie Lao; Alexander Pasternak; Sheng-Ping Wang; Joseph M Metzger; Alison M Strack; Tung M Fong; Richard Z Chen
The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist.
European journal of pharmacology 2006;545(2-3):147-52.
2006: Richard Z Chen; Andrea Frassetto; Tung M Fong
Effects of the CB1 cannabinoid receptor inverse agonist AM251 on food intake and body weight in mice lacking mu-opioid receptors.
Brain research 2006;1108(1):176-8.
2006: Ravi P Nargund; Alison M Strack; Tung M Fong
Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity.
Journal of medicinal chemistry 2006;49(14):4035-43.
2006: Yan Dong; Joanna P Tyszkiewicz; Tung M Fong
Galanin and galanin-like peptide differentially modulate neuronal activities in rat arcuate nucleus neurons.
Journal of neurophysiology 2006;95(5):3228-34.
2006: Jiaping Zhang; Chun-Pyn Shen; Jing Chen Xiao; Thomas J Lanza; Linus S Lin; Barbara E Francis; Tung M Fong; Richard Z Chen
Effects of mutations at conserved TM II residues on ligand binding and activation of mouse 5-HT6 receptor.
European journal of pharmacology 2006;534(1-3):77-82.
2006: Chun-Pyn Shen; Jing Chen Xiao; Helen Armstrong; William K Hagmann; Tung M Fong
F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist.
European journal of pharmacology 2006;531(1-3):41-6.
2006: Steven B Heymsfield; Tung M Fong; Ira Gantz; Ngozi Erondu
Fat and energy partitioning: longitudinal observations in leptin-treated adults homozygous for a Lep mutation.
Obesity (Silver Spring, Md.) 2006;14(2):258-65.
2006: John S Debenham; Christina B Madsen-Duggan; Thomas F Walsh; Junying Wang; Xinchun Tong; George A Doss; Julie Lao; Tung M Fong; Marie-Therese Schaeffer; Jing Chen Xiao; Cathy R-R C Huang; Chun-Pyn Shen; Yue Feng; Donald J Marsh; D Sloan Stribling; Lauren P Shearman; Alison M Strack; D Euan MacIntyre; Lex H T Van Der Ploeg; Mark T Goulet
Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists.
Bioorganic & medicinal chemistry letters 2006;16(3):681-5.
2005: Irina D Pogozheva; Biaoxin Chai; Andrei L Lomize; Tung M Fong; David Weinberg; Ravi P Nargund; Michael W Mulholland; Ira Gantz; Henry I Mosberg
Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists.
Biochemistry 2005;44(34):11329-41.
2005: Tung M Fong
Advances in anti-obesity therapeutics.
Expert opinion on investigational drugs 2005;14(3):243-50.
2005: Christopher W Plummer; Paul E Finke; Sander G Mills; Junying Wang; Xinchun Tong; George A Doss; Tung M Fong; Julie Lao; Marie-Therese Schaeffer; Jing Chen; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Lex H T Van Der Ploeg
Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists.
Bioorganic & medicinal chemistry letters 2005;15(5):1441-6.
2005: Laura C Meurer; Paul E Finke; Sander G Mills; Thomas F Walsh; Richard B Toupence; John S Debenham; Mark T Goulet; Junying Wang; Xinchun Tong; Tung M Fong; Julie Lao; Marie-Therese Schaeffer; Jing Chen; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Lex H T Van Der Ploeg
Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists.
Bioorganic & medicinal chemistry letters 2005;15(3):645-51.
2004: Tung M Fong
Targeting metabolic syndrome.
Expert opinion on investigational drugs 2004;13(9):1203-6.
2004: Richard Z Chen; Ruey-Ruey C Huang; Chun-Pyn Shen; Douglas J MacNeil; Tung M Fong
Chronic administration of nalmefene leads to increased food intake and body weight gain in mice.
European journal of pharmacology 2004;495(1):63-6.
2004: Richard Z Chen; Ruey-Ruey C Huang; Chun-Pyn Shen; Douglas J MacNeil; Tung M Fong
Synergistic effects of cannabinoid inverse agonist AM251 and opioid antagonist nalmefene on food intake in mice.
Brain research 2004;999(2):227-30.
2003: Ira Gantz; Tung M Fong
The melanocortin system.
American journal of physiology. Endocrinology and metabolism 2003;284(3):E468-74.
2002: Douglas J MacNeil; Andrew D Howard; Xiaoming Guan; Tung M Fong; Ravi P Nargund; Maria A Bednarek; Mark T Goulet; David Weinberg; Alison M Strack; Donald J Marsh; Howard Y Chen; Chun-Pyn Shen; Airu S Chen; Charles I Rosenblum; Tanya MacNeil; Michael R Tota; Euan D MacIntyre; Lex H T Van Der Ploeg
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
European journal of pharmacology 2002;450(1):93-109.
2002: Chun-Pyn Shen; K K Wu; Lauren P Shearman; Ramon E Camacho; Michael R Tota; Tung M Fong; Lex H T Van Der Ploeg
Plasma agouti-related protein level: a possible correlation with fasted and fed states in humans and rats.
Journal of neuroendocrinology 2002;14(8):607-10.
2002: Jie Liu; Zhege J Lao; Jiaping Zhang; Marie-Therese Schaeffer; Michael M Jiang; Xiao-Ming Guan; Lex H T Van Der Ploeg; Tung M Fong
Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).
Biochemistry 2002;41(28):8954-60.
2002: Douglas J MacNeil; Andrew D Howard; Xiaoming Guan; Tung M Fong; Ravi P Nargund; Maria A Bednarek; Mark T Goulet; David Weinberg; Alison M Strack; Donald J Marsh; Howard Y Chen; Chun-Pyn Shen; Airu S Chen; Charles I Rosenblum; Tanya MacNeil; Michael R Tota; Euan D MacIntyre; Lex H T Van Der Ploeg
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
European journal of pharmacology 2002;440(2-3):141-57.
2000: Ying-Kui Yang; Tung M Fong; Chris J Dickinson; C Mao; Ji-yao Li; Michael R Tota; Ralph T Mosley; Lex H T Van Der Ploeg; Ira Gantz
Molecular determinants of ligand binding to the human melanocortin-4 receptor.
Biochemistry 2000;39(48):14900-11.
2000: Tung M Fong; Lex H T Van Der Ploeg
A melanocortin agonist reduces neuronal firing rate in rat hypothalamic slices.
Neuroscience letters 2000;283(1):5-8.
2000: Ruey-Ruey C Huang; G Singh; Lex H T Van Der Ploeg; Tung M Fong
Species-dependent pharmacological properties of the melanocortin-5 receptor.
Journal of receptor and signal transduction research 2000;20(1):47-59.
1999: Marie-Therese Schaeffer; Doris F Cully; M Chou; J Liu; Lex H T Van Der Ploeg; Tung M Fong
Use of bioluminescent aequorin for the pharmacological characterization of 5HT receptors.
Journal of receptor and signal transduction research 1999;19(6):927-38.
1999: Michael R Tota; T S Smith; C Mao; Tanya MacNeil; Ralph T Mosley; Lex H T Van Der Ploeg; Tung M Fong
Molecular interaction of Agouti protein and Agouti-related protein with human melanocortin receptors.
Biochemistry 1999;38(3):897-904.
1998: Tung M Fong; Ruey-Ruey C Huang; Michael R Tota; C Mao; T Smith; Jeffrey P Varnerin; VV Karpitskiy; James E Krause; Lex H T Van Der Ploeg
Localization of leptin binding domain in the leptin receptor.
Molecular pharmacology 1998;53(2):234-40.
1997: Tung M Fong; C Mao; Tanya MacNeil; Rubana N Kalyani; T Smith; David Weinberg; Michael R Tota; Lex H T Van Der Ploeg
ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors.
Biochemical and biophysical research communications 1997;237(3):629-31.
1997: Ruey-Ruey C Huang; D Rapoport; Marie-Therese Schaeffer; Margaret A Cascieri; Tung M Fong
Molecular cloning of the dog beta 1 and beta 2 adrenergic receptors.
Journal of receptor and signal transduction research 1997;17(4):599-607.
1997: Margaret A Cascieri; E Ber; Tung M Fong; Jeffrey J Hale; F Tang; LL Shiao; Sander G Mills; Malcolm MacCoss; Sharon Sadowski; Michael R Tota; Catherine D Strader
Characterization of the binding and activity of a high affinity, pseudoirreversible morpholino tachykinin NK1 receptor antagonist.
European journal of pharmacology 1997;325(2-3):253-61.
1996: Tung M Fong; H Yu; Ruey-Ruey C Huang; Margaret A Cascieri; Christopher J Swain
Relative contribution of polar interactions and conformational compatibility to the binding of neurokinin-1 receptor antagonists.
Molecular pharmacology 1996;50(6):1605-11.
1996: Charles I Rosenblum; Michael R Tota; Doris F Cully; T Smith; R Collum; S Qureshi; J Fred Hess; M S Phillips; Patricia J Hey; Aurawan Vongs; Tung M Fong; L Xu; H Y Chen; Roy G Smith; C Schindler; Lex H T Van Der Ploeg
Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells.
Endocrinology 1996;137(11):5178-81.
1996: K E Mazina; Catherine D Strader; Michael R Tota; S Daniel; Tung M Fong
Purification and reconstitution of a recombinant human neurokinin-1 receptor.
Journal of receptor and signal transduction research 1996;16(3-4):191-207.
1996: Tung M Fong
Mechanistic hypotheses for the activation of G-protein-coupled receptors.
Cellular signalling 1996;8(3):217-24.
1995: Ruey-Ruey C Huang; D Huang; Catherine D Strader; Tung M Fong
Conformational compatibility as a basis of differential affinities of tachykinins for the neurokinin-1 receptor.
Biochemistry 1995;34(50):16467-72.
1995: Christopher J Swain; E M Seward; Margaret A Cascieri; Tung M Fong; R Herbert; D Euan MacIntyre; Kevin J Merchant; S N Owen; Andrew P Owens; V Sabin
Identification of a series of 3-(benzyloxy)-1-azabicyclo[2.2.2]octane human NK1 antagonists.
Journal of medicinal chemistry 1995;38(24):4793-805.
1995: Ruey-Ruey C Huang; Pasquale P Vicario; Catherine D Strader; Tung M Fong
Identification of residues involved in ligand binding to the neurokinin-2 receptor.
Biochemistry 1995;34(31):10048-55.
1995: Margaret A Cascieri; Tung M Fong; Catherine D Strader
Molecular characterization of a common binding site for small molecules within the transmembrane domain of G-protein coupled receptors.
Journal of pharmacological and toxicological methods 1995;33(4):179-85.
1995: Tung M Fong; R C Huang; H Yu; Christopher J Swain; D Underwood; Margaret A Cascieri; Catherine D Strader
Mutational analysis of neurokinin receptor function.
Canadian journal of physiology and pharmacology 1995;73(7):860-5.
1995: Catherine D Strader; Tung M Fong; M P Graziano; Michael R Tota
The family of G-protein-coupled receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(9):745-54.
1995: Angus M MacLeod; Margaret A Cascieri; Kevin J Merchant; Sharon Sadowski; S Hardwicke; R T Lewis; D Euan MacIntyre; Joseph M Metzger; Tung M Fong; Sara Shepheard
Synthesis and biological evaluation of NK1 antagonists derived from L-tryptophan.
Journal of medicinal chemistry 1995;38(6):934-41.
1994: Michael R Tota; S Daniel; A Sirotina; K E Mazina; Tung M Fong; J Longmore; Catherine D Strader
Characterization of a fluorescent substance P analog.
Biochemistry 1994;33(44):13079-86.
1994: Tung M Fong; Catherine D Strader
Functional mapping of the ligand binding sites of G-protein coupled receptors.
Medicinal research reviews 1994;14(4):387-99.
1994: Tung M Fong; H Yu; Margaret A Cascieri; D Underwood; Christopher J Swain; Catherine D Strader
Interaction of glutamine 165 in the fourth transmembrane segment of the human neurokinin-1 receptor with quinuclidine antagonists.
The Journal of biological chemistry 1994;269(21):14957-61.
1994: Ruey-Ruey C Huang; H Yu; Catherine D Strader; Tung M Fong
Localization of the ligand binding site of the neurokinin-1 receptor: interpretation of chimeric mutations and single-residue substitutions.
Molecular pharmacology 1994;45(4):690-5.
1994: Ruey-Ruey C Huang; H Yu; Catherine D Strader; Tung M Fong
Interaction of substance P with the second and seventh transmembrane domains of the neurokinin-1 receptor.
Biochemistry 1994;33(10):3007-13.
1994: Tung M Fong; H Yu; Margaret A Cascieri; D Underwood; Christopher J Swain; Catherine D Strader
The role of histidine 265 in antagonist binding to the neurokinin-1 receptor.
The Journal of biological chemistry 1994;269(4):2728-32.
1994: K E Mazina; Catherine D Strader; Tung M Fong
Expression and solubilization of a recombinant human neurokinin-1 receptor in insect cells.
Journal of receptor research 1994;14(1):63-73.
1994: Catherine D Strader; Tung M Fong; Michael R Tota; D Underwood; R A Dixon
Structure and function of G protein-coupled receptors.
Annual review of biochemistry 1994;63():101-32.
1993: Tung M Fong; Ruey-Ruey C Huang; H Yu; Catherine D Strader
Mapping the ligand binding site of the NK-1 receptor.
Regulatory peptides 1993;46(1-2):43-8.
1993: Sharon Sadowski; Ruey-Ruey C Huang; Tung M Fong; O Marko; Margaret A Cascieri
Characterization of the binding of [125I-iodo-histidyl, methyl-Phe7] neurokinin B to the neurokinin-3 receptor.
Neuropeptides 1993;24(6):317-9.
1993: Tung M Fong; Margaret A Cascieri; H Yu; A Bansal; Christopher J Swain; Catherine D Strader
Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345.
Nature 1993;362(6418):350-3.
1992: Tung M Fong; H Yu; Catherine D Strader
Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580.
The Journal of biological chemistry 1992;267(36):25668-71.
1992: Tung M Fong; Ruey-Ruey C Huang; Catherine D Strader
Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.
The Journal of biological chemistry 1992;267(36):25664-7.
1992: Tung M Fong; H Yu; Ruey-Ruey C Huang; Catherine D Strader
The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides.
Biochemistry 1992;31(47):11806-11.
1992: Margaret A Cascieri; E Ber; Tung M Fong; Sharon Sadowski; A Bansal; Christopher J Swain; E Seward; B Frances; D Burns; Catherine D Strader
Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor.
Molecular pharmacology 1992;42(3):458-63.
1992: Margaret A Cascieri; Ruey-Ruey C Huang; Tung M Fong; A H Cheung; Sharon Sadowski; E Ber; Catherine D Strader
Determination of the amino acid residues in substance P conferring selectivity and specificity for the rat neurokinin receptors.
Molecular pharmacology 1992;41(6):1096-9.
1992: Ruey-Ruey C Huang; A H Cheung; K E Mazina; Catherine D Strader; Tung M Fong
cDNA sequence and heterologous expression of the human neurokinin-3 receptor.
Biochemical and biophysical research communications 1992;184(2):966-72.
1992: Tung M Fong; H Yu; Catherine D Strader
The extracellular domain of substance P (NK1) receptor comprises part of the ligand binding site.
Biophysical journal 1992;62(1):59-60.
1992: Tung M Fong; S A Anderson; H Yu; Ruey-Ruey C Huang; Catherine D Strader
Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor.
Molecular pharmacology 1992;41(1):24-30.