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Adriano Fontana

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Mike Recher; Dominik J Schaer; Thomas Birchler; Heike Claus; Heidemarie Gast; Uwe Koedel; Ursula Malipiero; Ulf Petrausch; Hans-Walter Pfister; Adriano Fontana
Inhibition of meningitis-associated neutrophil apoptosis by TNF-α depends on functional PI3-kinase in monocytes.
Mike Recher; Ulrike Sahrbacher; Urs Steiner; Börge Arndt; Juliane Bremer; Adriano Fontana
Treatment of inclusion body myositis: is low-dose intravenous immunoglobulin the solution?
Tobias Hoegen; Carsten J Kirschning; Matthias Klein; Barbara Angele; Adriano Fontana; Sven Hammerschmidt; Hans-Walter Pfister; Nadin Tremel; Hermann Wagner; Uwe Koedel
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.

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2013: Mike Recher; Dominik J Schaer; Thomas Birchler; Heike Claus; Heidemarie Gast; Uwe Koedel; Ursula Malipiero; Ulf Petrausch; Hans-Walter Pfister; Adriano Fontana
Inhibition of meningitis-associated neutrophil apoptosis by TNF-α depends on functional PI3-kinase in monocytes.
Journal of leukocyte biology 2013;93(2):259-66.
2012: Mike Recher; Ulrike Sahrbacher; Urs Steiner; Börge Arndt; Juliane Bremer; Adriano Fontana
Treatment of inclusion body myositis: is low-dose intravenous immunoglobulin the solution?
Rheumatology international 2012;32(2):469-72.
2011: Tobias Hoegen; Carsten J Kirschning; Matthias Klein; Barbara Angele; Adriano Fontana; Sven Hammerschmidt; Hans-Walter Pfister; Nadin Tremel; Hermann Wagner; Uwe Koedel
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5440-51.
2011: Laura Codarri; Gabor Gyülvészi; Vinko Tosevski; Lysann Hesske; Adriano Fontana; Laurent Magnenat; Tobias Suter; Burkhard Becher
RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.
Nature immunology 2011;12(6):560-7.
2011: Martijn Moransard; Angela Dann; Ori Staszewski; Adriano Fontana; Marco Prinz; Tobias Suter
NG2 expressed by macrophages and oligodendrocyte precursor cells is dispensable in experimental autoimmune encephalomyelitis.
Brain : a journal of neurology 2011;134(Pt 5):1315-30.
2011: Cornelia Taraborrelli; Svitlana Palchykova; Irene Tobler; Heidemarie Gast; Thomas Birchler; Adriano Fontana
TNFR1 is essential for CD40, but not for lipopolysaccharide-induced sickness behavior and clock gene dysregulation.
Brain, behavior, and immunity 2011;25(3):434-42.
2010: Magali Irla; Natalia Küpfer; Tobias Suter; Rami Lissilaa; Mahdia Benkhoucha; Jonathan Skupsky; Patrice H Lalive; Adriano Fontana; Walter Reith; Stéphanie Hugues
MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity.
The Journal of experimental medicine 2010;207(9):1891-905.
2010: Laura Codarri; Adriano Fontana; Burkhard Becher
Cytokine networks in multiple sclerosis: lost in translation.
Current opinion in neurology 2010;23(3):205-11.
2010: Lysann Hesske; Christine Vincenzetti; Mathias Heikenwalder; Marco Prinz; Walter Reith; Adriano Fontana; Tobias Suter
Induction of inhibitory central nervous system-derived and stimulatory blood-derived dendritic cells suggests a dual role for granulocyte-macrophage colony-stimulating factor in central nervous system inflammation.
Brain : a journal of neurology 2010;133(Pt 6):1637-54.
2010: Adriano Fontana; Heidemarie Gast; Walter Reith; Mike Recher; Thomas Birchler; Claudio Bassetti
Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss?
Brain : a journal of neurology 2010;133(Pt 5):1300-11.
2010: Martijn Moransard; Mandy Sawitzky; Adriano Fontana; Tobias Suter
Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.
Glia 2010;58(5):559-71.
2009: Saskia Petrzilka; Cornelia Taraborrelli; Gionata Cavadini; Adriano Fontana; Thomas Birchler
Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling.
Journal of biological rhythms 2009;24(4):283-94.
2009: Gregoire Biollaz; Luca Bernasconi; Christine Cretton; Ursula Püntener; Karl Frei; Adriano Fontana; Tobias Suter
Site-specific anti-tumor immunity: differences in DC function, TGF-beta production and numbers of intratumoral Foxp3+ Treg.
European journal of immunology 2009;39(5):1323-33.
2008: Hideyuki Ishihara; Hisashi Kubota; Raija L P Lindberg; David Leppert; Sergio M Gloor; Mariella Errede; Daniela Virgintino; Adriano Fontana; Yasuhiro Yonekawa; Karl Frei
Endothelial cell barrier impairment induced by glioblastomas and transforming growth factor beta2 involves matrix metalloproteinases and tight junction proteins.
Journal of neuropathology and experimental neurology 2008;67(5):435-48.
2007: Gionata Cavadini; Saskia Petrzilka; Philipp Kohler; Corinne Jud; Irene Tobler; Thomas Birchler; Adriano Fontana
TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12843-8.
2007: Ursula Malipiero; Uwe Koedel; Walter Pfister; Adriano Fontana
Bacterial meningitis: the role of transforming growth factor-Beta in innate immunity and secondary brain damage.
Neuro-degenerative diseases 2007;4(1):43-50.
2006: Ursula Malipiero; Uwe Koedel; Hans-Walter Pfister; Per Levéen; Kurt Bürki; Walter Reith; Adriano Fontana
TGFbeta receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis.
Brain : a journal of neurology 2006;129(Pt 9):2404-15.
2005: Patrice H Lalive; Rey Paglinawan; Gregoire Biollaz; Elisabeth A Kappos; Dino P Leone; Ursula Malipiero; João B Relvas; Martijn Moransard; Tobias Suter; Adriano Fontana
TGF-beta-treated microglia induce oligodendrocyte precursor cell chemotaxis through the HGF-c-Met pathway.
European journal of immunology 2005;35(3):727-37.
2005: Jörg H W Distler; Astrid Jüngel; Lars C Huber; Christian A Seemayer; Charles F Reich; Renate E Gay; Beat A Michel; Adriano Fontana; Steffen Gay; David S Pisetsky; Oliver Distler
The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2892-7.
2004: Salomé LeibundGut-Landmann; jean-marc waldburger; Michal Krawczyk; Luc A Otten; Tobias Suter; Adriano Fontana; Hans Acha-Orbea; Walter Reith
Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes.
European journal of immunology 2004;34(6):1513-25.
2003: Rey Paglinawan; Ursula Malipiero; Ralph Schlapbach; Karl Frei; Walter Reith; Adriano Fontana
TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes.
Glia 2003;44(3):219-31.
2003: Tobias Suter; Gregoire Biollaz; Dominique Gatto; Luca Bernasconi; Tobias Herren; Walter Reith; Adriano Fontana
The brain as an immune privileged site: dendritic cells of the central nervous system inhibit T cell activation.
European journal of immunology 2003;33(11):2998-3006.
2003: Robert Paul; Uwe Koedel; Frank Winkler; Bernd C Kieseier; Adriano Fontana; Manfred Kopf; Hans-Peter Hartung; Hans-Walter Pfister
Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis.
Brain : a journal of neurology 2003;126(Pt 8):1873-82.
2002: Uwe Koedel; Frank Winkler; Barbara Angele; Adriano Fontana; Richard A Flavell; Hans-Walter Pfister
Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice.
Annals of neurology 2002;51(3):319-29.
2002: Uwe Koedel; Frank Winkler; Barbara Angele; Adriano Fontana; Hans-Walter Pfister
Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(1):39-49.
2001: jean-marc waldburger; Tobias Suter; Adriano Fontana; Hans Acha-Orbea; Walter Reith
Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene.
The Journal of experimental medicine 2001;194(4):393-406.
2001: S Landmann; A Mühlethaler-Mottet; L Bernasconi; Tobias Suter; jean-marc waldburger; krzysztof masternak; Jean-François Arrighi; C Hauser; Adriano Fontana; Walter Reith
Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression.
The Journal of experimental medicine 2001;194(4):379-91.
2001: Hans-Pietro Eugster; Karl Frei; F Winkler; Uwe Koedel; W Pfister; H Lassmann; Adriano Fontana
Superantigen overcomes resistance of IL-6-deficient mice towards MOG-induced EAE by a TNFR1 controlled pathway.
European journal of immunology 2001;31(8):2302-12.
2000: Ralph Schlapbach; Katharina-Susanne Spanaus; Ursula Malipiero; S Lens; Andrea Tasinato; Jürg Tschopp; Adriano Fontana
TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia.
European journal of immunology 2000;30(12):3680-8.
2000: Tobias Suter; Ursula Malipiero; Luc A Otten; Burkhard Ludewig; A Muelethaler-Mottet; B Mach; Walter Reith; Adriano Fontana
Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis.
European journal of immunology 2000;30(3):794-802.
2000: Bernd Sporer; Uwe Koedel; Robert Paul; B Kohleisen; Volker Erfle; Adriano Fontana; Hans-Walter Pfister
Human immunodeficiency virus type-1 Nef protein induces blood-brain barrier disruption in the rat: role of matrix metalloproteinase-9.
Journal of neuroimmunology 2000;102(2):125-30.
2000: Ralph A Schmid; Uz Stammberger; Sven Hillinger; Ariana Gaspert; CH Boasquevisque; Ursula Malipiero; Adriano Fontana; Walter Weder
Fas ligand gene transfer combined with low dose cyclosporine A reduces acute lung allograft rejection.
Transplant international : official journal of the European Society for Organ Transplantation 2000;13 Suppl 1():S324-8.
1999: Marco Wachtel; Karl Frei; Elisabeth Ehler; Adriano Fontana; Kaspar Winterhalter; Sergio M Gloor
Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition.
Journal of cell science 1999;112 ( Pt 23)():4347-56.
1999: Ursula Malipiero; C Heuss; Ralph Schlapbach; Jürg Tschopp; Urs Gerber; Adriano Fontana
Involvement of the N-methyl-D-aspartate receptor in neuronal cell death induced by cytotoxic T cell-derived secretory granules.
European journal of immunology 1999;29(10):3053-62.
1999: Uwe Koedel; B Kohleisen; Bernd Sporer; F Lahrtz; Vladimir Ovod; Adriano Fontana; Volker Erfle; Hans-Walter Pfister
HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1237-45.
1999: BB Ambar; K Frei; Ursula Malipiero; A E Morelli; Maria G Castro; Pedro R Lowenstein; Adriano Fontana
Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand.
Human gene therapy 1999;10(10):1641-8.
1999: I Kemler; Adriano Fontana
Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha-stimulated astrocytes and in neuroblastoma cells.
Glia 1999;26(3):212-20.
1999: Hans-Pietro Eugster; Karl Frei; R Bachmann; H Bluethmann; H Lassmann; Adriano Fontana
Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1.
European journal of immunology 1999;29(2):626-32.
1999: SA Kolb; Bernd Sporer; F Lahrtz; Uwe Koedel; Hans-Walter Pfister; Adriano Fontana
Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-gamma inducible protein 10.
Journal of neuroimmunology 1999;93(1-2):172-81.
1998: Katharina-Susanne Spanaus; Ralph Schlapbach; Adriano Fontana
TNF-alpha and IFN-gamma render microglia sensitive to Fas ligand-induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL.
European journal of immunology 1998;28(12):4398-408.
1998: Juliane K Franz; SA Kolb; Klaus M Hummel; F Lahrtz; Michel Neidhart; Wilhelm K Aicher; Thomas Pap; Renate E Gay; Adriano Fontana; Steffen Gay
Interleukin-16, produced by synovial fibroblasts, mediates chemoattraction for CD4+ T lymphocytes in rheumatoid arthritis.
European journal of immunology 1998;28(9):2661-71.
1998: Hans-Pietro Eugster; Karl Frei; M Kopf; H Lassmann; Adriano Fontana
IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.
European journal of immunology 1998;28(7):2178-87.
1998: K Frei; BB Ambar; N Adachi; Y Yonekawa; Adriano Fontana
Ex vivo malignant glioma cells are sensitive to Fas (CD95/APO-1) ligand-mediated apoptosis.
Journal of neuroimmunology 1998;87(1-2):105-13.
1998: F Lahrtz; L Piali; Katharina-Susanne Spanaus; Jörg D Seebach; Adriano Fontana
Chemokines and chemotaxis of leukocytes in infectious meningitis.
Journal of neuroimmunology 1998;85(1):33-43.
1998: SA Kolb; F Lahrtz; R Paul; D Leppert; David Nadal; Hans-Walter Pfister; Adriano Fontana
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid.
Journal of neuroimmunology 1998;84(2):143-50.
1998: U C Sahrbacher; F Lechner; Hans-Pietro Eugster; Karl Frei; H Lassmann; Adriano Fontana
Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis.
European journal of immunology 1998;28(4):1332-8.
1997: Ursula Malipiero; Karl Frei; Katharina-Susanne Spanaus; C Agresti; H Lassmann; Michael Hahne; Jürg Tschopp; Hans-Pietro Eugster; Adriano Fontana
Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice.
European journal of immunology 1997;27(12):3151-60.
1997: Ralph Schlapbach; Adriano Fontana
Differential activity of bcl-2 and ICE enzyme family protease inhibitors on Fas and puromycin-induced apoptosis of glioma cells.
Biochimica et biophysica acta 1997;1359(2):174-80.
1997: F Lahrtz; L Piali; David Nadal; Hans-Walter Pfister; Katharina-Susanne Spanaus; M Baggiolini; Adriano Fontana
Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon-gamma inducible protein-10 and monocyte chemotactic protein-1.
European journal of immunology 1997;27(10):2484-9.
1997: Karl Frei; Hans-Pietro Eugster; M Bopst; C S Constantinescu; Ehud Lavi; Adriano Fontana
Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis.
The Journal of experimental medicine 1997;185(12):2177-82.
1997: S Atanasoski; E Schreiber; Adriano Fontana; Winship Herr
N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct 3.
Oncogene 1997;14(11):1287-94.
1997: Karl Frei; Adriano Fontana
Antigen presentation in the CNS.
Molecular psychiatry 1997;2(2):96-8.
1997: A R Tobler; D B Constam; A Schmitt-Gräff; Ursula Malipiero; Ralph Schlapbach; Adriano Fontana
Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons.
Journal of neurochemistry 1997;68(3):889-97.
1997: Katharina-Susanne Spanaus; David Nadal; Hans-Walter Pfister; Jörg D Seebach; Urs Widmer; Karl Frei; Sergio M Gloor; Adriano Fontana
C-X-C and C-C chemokines are expressed in the cerebrospinal fluid in bacterial meningitis and mediate chemotactic activity on peripheral blood-derived polymorphonuclear and mononuclear cells in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1956-64.
1996: Uwe Koedel; A Bernatowicz; K Frei; Adriano Fontana; Hans-Walter Pfister
Systemically (but not intrathecally) administered IL-10 attenuates pathophysiologic alterations in experimental pneumococcal meningitis.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5185-91.
1996: A Rensing-Ehl; Ursula Malipiero; M Irmler; J Tschopp; D Constam; Adriano Fontana
Neurons induced to express major histocompatibility complex class I antigen are killed via the perforin and not the Fas (APO-1/CD95) pathway.
European journal of immunology 1996;26(9):2271-4.
1995: D B Constam; A R Tobler; A Rensing-Ehl; I Kemler; Louis B Hersh; Adriano Fontana
Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization.
The Journal of biological chemistry 1995;270(45):26931-9.
1995: Jörg D Seebach; D Bartholdi; Karl Frei; Katharina-Susanne Spanaus; E Ferrero; U Widmer; S Isenmann; R M Strieter; M Schwab; H Pfister; Adriano Fontana
Experimental Listeria meningoencephalitis. Macrophage inflammatory protein-1 alpha and -2 are produced intrathecally and mediate chemotactic activity in cerebrospinal fluid of infected mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(9):4367-75.
1995: A Rensing-Ehl; Karl Frei; Renata Flury; B Matiba; SM Mariani; M Weller; P Aebischer; Peter H Krammer; Adriano Fontana
Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo.
European journal of immunology 1995;25(8):2253-8.
1995: Stefan Lorenzl; Uwe Koedel; K Frei; A Bernatowicz; Adriano Fontana; Hans-Walter Pfister
Protective effect of a 21-aminosteroid during experimental pneumococcal meningitis.
The Journal of infectious diseases 1995;172(1):113-8.
1995: A Bernatowicz; U Ködel; K Frei; Adriano Fontana; Hans-Walter Pfister
Production of nitrite by primary rat astrocytes in response to pneumococci.
Journal of neuroimmunology 1995;60(1-2):53-61.
1995: M Weller; Ursula Malipiero; A Rensing-Ehl; P J Barr; Adriano Fontana
Fas/APO-1 gene transfer for human malignant glioma.
Cancer research 1995;55(13):2936-44.
1995: M Weller; Ursula Malipiero; A Aguzzi; J C Reed; Adriano Fontana
Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation.
The Journal of clinical investigation 1995;95(6):2633-43.
1995: P Meier; M Koedood; J Philipp; Adriano Fontana; P J Mitchell
Alternative mRNAs encode multiple isoforms of transcription factor AP-2 during murine embryogenesis.
Developmental biology 1995;169(1):1-14.
1995: S Atanasoski; S S Toldo; Ursula Malipiero; E Schreiber; R Fries; Adriano Fontana
Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16.
Genomics 1995;26(2):272-80.
1995: Uwe Koedel; A Bernatowicz; Robert Paul; K Frei; Adriano Fontana; Hans-Walter Pfister
Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide.
Annals of neurology 1995;37(3):313-23.
1994: J Philipp; P J Mitchell; Ursula Malipiero; Adriano Fontana
Cell type-specific regulation of expression of transcription factor AP-2 in neuroectodermal cells.
Developmental biology 1994;165(2):602-14.
1994: Hans-Walter Pfister; Adriano Fontana; M G Täuber; A Tomasz; W M Scheld
Mechanisms of brain injury in bacterial meningitis: workshop summary.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1994;19(3):463-79.
1994: M Weller; K Frei; P Groscurth; P H Krammer; Y Yonekawa; Adriano Fontana
Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.
The Journal of clinical investigation 1994;94(3):954-64.
1994: Adriano Fontana; U Widmer; Rudolf Speich; B Michel
[Diagnosis and course assessment of collagenoses and vasculitides].
Schweizerische medizinische Wochenschrift 1994;124(25):1096-102.
1994: M Weller; D B Constam; Ursula Malipiero; Adriano Fontana
Transforming growth factor-beta 2 induces apoptosis of murine T cell clones without down-regulating bcl-2 mRNA expression.
European journal of immunology 1994;24(6):1293-300.
1994: D B Constam; P Schmid; A Aguzzi; M Schachner; Adriano Fontana
Transient production of TGF-beta 2 by postnatal cerebellar neurons and its effect on neuroblast proliferation.
The European journal of neuroscience 1994;6(5):766-78.
1994: D Piani; Adriano Fontana
Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3578-85.
1994: Karl Frei; Ursula Malipiero; D Piani; Adriano Fontana
Microglia and tumor rejection.
Neuropathology and applied neurobiology 1994;20(2):206-8.
1994: Karl Frei; H Lins; C Schwerdel; Adriano Fontana
Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2720-8.
1994: E Schreiber; Randall Merchant; O D Wiestler; Adriano Fontana
Primary brain tumors differ in their expression of octamer deoxyribonucleic acid-binding transcription factors from long-term cultured glioma cell lines.
Neurosurgery 1994;34(1):129-35.
1994: K Frei; H Lins; Adriano Fontana
Production and function of IL-10 in the central nervous system.
Schweizer Archiv für Neurologie und Psychiatrie (Zurich, Switzerland : 1985) 1994;145(3):30-1.
1993: Karl Frei; D Nadal; Hans-Walter Pfister; Adriano Fontana
Listeria meningitis: identification of a cerebrospinal fluid inhibitor of macrophage listericidal function as interleukin 10.
The Journal of experimental medicine 1993;178(4):1255-61.
1993: D Piani; Karl Frei; H W Pfister; Adriano Fontana
Glutamate uptake by astrocytes is inhibited by reactive oxygen intermediates but not by other macrophage-derived molecules including cytokines, leukotrienes or platelet-activating factor.
Journal of neuroimmunology 1993;48(1):99-104.
1993: M Müller; Adriano Fontana; G Zbinden; Beat H Gähwiler
Effects of interferons and hydrogen peroxide on CA3 pyramidal cells in rat hippocampal slice cultures.
Brain research 1993;619(1-2):157-62.
1993: A Tobler; E Schreiber; Adriano Fontana
The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart.
Nucleic acids research 1993;21(4):1043.
1993: E Schreiber; A Tobler; Ursula Malipiero; Walter Schaffner; Adriano Fontana
cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif.
Nucleic acids research 1993;21(2):253-8.
1993: Karl Frei; D Piani; H W Pfister; Adriano Fontana
Immune-mediated injury in bacterial meningitis.
International review of experimental pathology 1993;34 Pt B():183-92.
1993: D B Constam; Adriano Fontana
Not only glioblastoma cells but also untransformed glia cells express transforming growth factor beta.
Schweizer Archiv für Neurologie und Psychiatrie (Zurich, Switzerland : 1985) 1993;144(3):225-7.
1992: E Schreiber; A Himmelmann; Ursula Malipiero; A Tobler; Rolf A Stahel; Adriano Fontana
Human small cell lung cancer expresses the octamer DNA-binding and nervous system-specific transcription factor N-Oct 3 (brain-2).
Cancer research 1992;52(21):6121-4.
1992: Karl Frei; K Nohava; Ursula Malipiero; C Schwerdel; Adriano Fontana
Production of macrophage colony-stimulating factor by astrocytes and brain macrophages.
Journal of neuroimmunology 1992;40(2-3):189-95.
1992: K Nohava; Ursula Malipiero; Karl Frei; Adriano Fontana
Neurons and neuroblastoma as a source of macrophage colony-stimulating factor.
European journal of immunology 1992;22(10):2539-45.
1992: D Piani; M Spranger; Karl Frei; A Schaffner; Adriano Fontana
Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines.
European journal of immunology 1992;22(9):2429-36.
1992: Hans-Walter Pfister; K Frei; B Ottnad; Uwe Koedel; A Tomasz; Adriano Fontana
Transforming growth factor beta 2 inhibits cerebrovascular changes and brain edema formation in the tumor necrosis factor alpha-independent early phase of experimental pneumococcal meningitis.
The Journal of experimental medicine 1992;176(1):265-8.
1992: Karl Frei; D Piani; Ursula Malipiero; Erwin Van Meir; N de Tribolet; Adriano Fontana
Granulocyte-macrophage colony-stimulating factor (GM-CSF) production by glioblastoma cells. Despite the presence of inducing signals GM-CSF is not expressed in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(10):3140-6.
1992: D B Constam; J Philipp; Ursula Malipiero; Peter ten Dijke; M Schachner; Adriano Fontana
Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(5):1404-10.
1992: D Huber; J Philipp; Adriano Fontana
Protease inhibitors interfere with the transforming growth factor-beta-dependent but not the transforming growth factor-beta-independent pathway of tumor cell-mediated immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):277-84.
1992: Adriano Fontana; D B Constam; Karl Frei; Ursula Malipiero; H W Pfister
Modulation of the immune response by transforming growth factor beta.
International archives of allergy and immunology 1992;99(1):1-7.
1991: D Piani; Karl Frei; Kim Q Do; M Cuénod; Adriano Fontana
Murine brain macrophages induced NMDA receptor mediated neurotoxicity in vitro by secreting glutamate.
Neuroscience letters 1991;133(2):159-62.
1991: S Bodmer; D Huber; I Heid; Adriano Fontana
Human glioblastoma cell derived transforming growth factor-beta 2: evidence for secretion of both high and low molecular weight biologically active forms.
Journal of neuroimmunology 1991;34(1):33-42.
1991: C Siepl; Ursula Malipiero; Adriano Fontana
Transforming growth factor-beta (TGF-beta)-resistant helper T lymphocyte clones show a concomitant loss of all three types of TGF-beta receptors.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(9):3063-7.
1991: Karl Frei; Sten Fredrikson; Adriano Fontana; H Link
Interleukin-6 is elevated in plasma in multiple sclerosis.
Journal of neuroimmunology 1991;31(2):147-53.
1991: Ursula Malipiero; S Brunati; D Constam; Karl Frei; Adriano Fontana
Regulation of expression of TGF-beta 2 in the nervous system.
Schweizer Archiv für Neurologie und Psychiatrie (Zurich, Switzerland : 1985) 1991;142(2):134-5.
1991: Adriano Fontana; S Bodmer; Karl Frei; Ursula Malipiero; C Siepl
Expression of TGF-beta 2 in human glioblastoma: a role in resistance to immune rejection?
Ciba Foundation symposium 1991;157():232-8; discussion 238-41.
1990: Ursula Malipiero; M Höller; U Werner; Adriano Fontana
Sequence analysis of the promoter region of the glioblastoma derived T cell suppressor factor/transforming growth factor (TGF)-beta 2 gene reveals striking differences to the TGF-beta 1 and -beta 3 genes.
Biochemical and biophysical research communications 1990;171(3):1145-51.
1990: E Schreiber; K Harshman; I Kemler; Ursula Malipiero; Walter Schaffner; Adriano Fontana
Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins.
Nucleic acids research 1990;18(18):5495-503.
1990: S Bodmer; M B Podlisny; Dennis J Selkoe; I Heid; Adriano Fontana
Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease.
Biochemical and biophysical research communications 1990;171(2):890-7.
1990: Ursula Malipiero; Karl Frei; Adriano Fontana
Production of hemopoietic colony-stimulating factors by astrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(10):3816-21.
1990: Karl Frei; D Nadal; Adriano Fontana
Intracerebral synthesis of tumor necrosis factor-alpha and interleukin-6 in infectious meningitis.
Annals of the New York Academy of Sciences 1990;594():326-35.
1989: Adriano Fontana; Karl Frei; S Bodmer; Erhard Hofer; M H Schreier; M A Palladino; Rolf M Zinkernagel
Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3230-4.
1989: S Bodmer; K Strommer; Karl Frei; C Siepl; N de Tribolet; I Heid; Adriano Fontana
Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3222-9.
1989: D Leppert; Karl Frei; P Gallo; M G Yasargil; K Hess; G Baumgartner; Adriano Fontana
Brain tumors: detection of B-cell stimulatory factor-2/interleukin-6 in the absence of oligoclonal bands of immunoglobulins.
Journal of neuroimmunology 1989;24(3):259-64.
1989: D Nadal; D Leppert; Karl Frei; P Gallo; H Lamche; Adriano Fontana
Tumour necrosis factor-alpha in infectious meningitis.
Archives of disease in childhood 1989;64(9):1274-9.
1989: Karl Frei; Ursula Malipiero; T P Leist; Rolf M Zinkernagel; M E Schwab; Adriano Fontana
On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases.
European journal of immunology 1989;19(4):689-94.
1988: Karl Frei; T P Leist; A Meager; P Gallo; D Leppert; Rolf M Zinkernagel; Adriano Fontana
Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.
The Journal of experimental medicine 1988;168(1):449-53.
1988: C Siepl; S Bodmer; Karl Frei; H R MacDonald; Rainer de Martin; Erhard Hofer; Adriano Fontana
The glioblastoma-derived T cell suppressor factor/transforming growth factor-beta 2 inhibits T cell growth without affecting the interaction of interleukin 2 with its receptor.
European journal of immunology 1988;18(4):593-600.
1988: C Siepl; S Bodmer; Erhard Hofer; M Wrann; Karl Frei; Adriano Fontana
Glioblastoma-cell-derived T-cell suppressor factor (G-TsF). Sequence analysis and biologic mechanism of G-TsF.
Annals of the New York Academy of Sciences 1988;540():437-9.
1988: T Stolzenburg; H Binz; Adriano Fontana; M Felder; F J Wagenhaeuser
Impaired mitogen-induced interferon-gamma production in rheumatoid arthritis and related diseases.
Scandinavian journal of immunology 1988;27(1):73-81.
1988: Karl Frei; C Siepl; P Groscurth; S Bodmer; Adriano Fontana
Immunobiology of microglial cells.
Annals of the New York Academy of Sciences 1988;540():218-27.
1987: Adriano Fontana; Karl Frei; S Bodmer; Erhard Hofer
Immune-mediated encephalitis: on the role of antigen-presenting cells in brain tissue.
Immunological reviews 1987;100():185-201.
1987: Rainer de Martin; B Haendler; Renate Hofer-Warbinek; H Gaugitsch; M Wrann; H Schlüsener; J M Seifert; S Bodmer; Adriano Fontana; Erhard Hofer
Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.
The EMBO journal 1987;6(12):3673-7.
1987: D Umbricht; G Keusch; H R Burger; H Joller; Adriano Fontana
[Essential cryoglobulinemia with glomerulonephritis as a variant of the purpura-arthralgia-nephritis syndrome].
Schweizerische medizinische Wochenschrift 1987;117(44):1723-7.
1987: Karl Frei; C Siepl; P Groscurth; S Bodmer; C Schwerdel; Adriano Fontana
Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cells.
European journal of immunology 1987;17(9):1271-8.
1987: M Wrann; S Bodmer; Rainer de Martin; C Siepl; Renate Hofer-Warbinek; Karl Frei; Erhard Hofer; Adriano Fontana
T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.
The EMBO journal 1987;6(6):1633-6.
1986: Karl Frei; S Bodmer; C Schwerdel; Adriano Fontana
Astrocyte-derived interleukin 3 as a growth factor for microglia cells and peritoneal macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(11):3521-7.
1985: Karl Frei; S Bodmer; C Schwerdel; Adriano Fontana
Astrocytes of the brain synthesize interleukin 3-like factors.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(6):4044-7.