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Joseph Fontana

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Lulu Farhana; Jayanta K Das; Marcia I Dawson; Farhan Murshed; Arun K Rishi; Joseph A Fontana
Upregulation of miR-150* and miR-630 Induces Apoptosis in Pancreatic Cancer Cells by Targeting IGF-1R.
Zebin Xia; Jayanta K Das; Jinghua Yu; David J Castro; Joseph A Fontana; John C Reed; Ricardo G Correa; Robert Glen Oshima; Lulu Farhana; Marcia I Dawson
Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines.
Shin Ogita; Daryn Smith; Sheela Tejwani; Karen Baranowski; Joseph A Fontana; Stacy Freeman; Elisabeth Iljas Heath; Lance K Heilbrun; Ulka Nitin Vaishampayan
Pilot Phase II Trial of Bevacizumab Monotherapy in Nonmetastatic Castrate-Resistant Prostate Cancer.

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2013: Lulu Farhana; Jayanta K Das; Marcia I Dawson; Farhan Murshed; Arun K Rishi; Joseph A Fontana
Upregulation of miR-150* and miR-630 Induces Apoptosis in Pancreatic Cancer Cells by Targeting IGF-1R.
PloS one 2013;8(5):e61015.
2012: Zebin Xia; Jayanta K Das; Jinghua Yu; David J Castro; Joseph A Fontana; John C Reed; Ricardo G Correa; Robert Glen Oshima; Lulu Farhana; Marcia I Dawson
Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines.
Journal of medicinal chemistry 2012;55(1):233-49.
2012: Shin Ogita; Daryn Smith; Sheela Tejwani; Karen Baranowski; Joseph A Fontana; Stacy Freeman; Elisabeth Iljas Heath; Lance K Heilbrun; Ulka Nitin Vaishampayan
Pilot Phase II Trial of Bevacizumab Monotherapy in Nonmetastatic Castrate-Resistant Prostate Cancer.
ISRN oncology 2012;2012():242850.
2012: Lulu Farhana; Jayanta K Das; Marcia I Dawson; Timothy J Hadden; James Hatfield; Farhan Murshed; Zebin Xia; Joseph A Fontana
Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways.
Journal of oncology 2012;2012():796729.
2011: Zebin Xia; Lulu Farhana; Ricardo G Correa; Jayanta K Das; David J Castro; Jinghua Yu; Robert Glen Oshima; John C Reed; Joseph A Fontana; Marcia I Dawson
Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid.
Journal of medicinal chemistry 2011;54(11):3793-816.
2011: L Farhana; M I Dawson; F Murshed; Joseph A Fontana
Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-κB noncanonical and canonical pathway activation.
Cell death and differentiation 2011;18(1):164-73.
2010: Lulu Farhana; Marcia I Dawson; Zebin Xia; Amro Aboukameel; Liping Xu; Gang Liu; Jayanta K Das; James Hatfield; Edi Levi; Ramzi M Mohammad; Joseph A Fontana
Adamantyl-substituted retinoid-related molecules induce apoptosis in human acute myelogenous leukemia cells.
Molecular cancer therapeutics 2010;9(11):2903-13.
2010: Marcia I Dawson; Joseph A Fontana
The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: structure-activity relationships and retinoid receptor-independent anticancer activities.
Mini reviews in medicinal chemistry 2010;10(6):455-91.
2010: Liyue Zhang; Anil Wali; Joseph A Fontana; Marcia I Dawson; Arun K Rishi
Novel cis-trans interactions are involved in post-transcriptional regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 mRNA.
Journal of molecular signaling 2010;5():12.
2010: Yan Jiang; Vineshkumar T Puliyappadamba; Liyue Zhang; Wenjuan Wu; Anil Wali; Michael B Yaffe; Joseph A Fontana; Arun K Rishi
A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1.
Journal of molecular signaling 2010;5():7.
2009: Marcia I Dawson; Mao Ye; Xihua Cao; Lulu Farhana; Qiong-Ying Hu; Yong Zhao; Li Ping Xu; Alice Kiselyuk; Ricardo G Correa; Li Yang; Tingjun Hou; John C Reed; Pamela Itkin-Ansari; Fred Levine; Michel F Sanner; Joseph A Fontana; Xiao-kun Zhang
Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene.
ChemMedChem 2009;4(7):1106-19.
2009: Lulu Farhana; Marcia I Dawson; Jan-Hermen Dannenberg; Liping Xu; Joseph A Fontana
SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis.
Molecular cancer therapeutics 2009;8(6):1625-35.
2008: Sridhar Srinivasan; Venkata Parsa; Chin Y Liu; Joseph A Fontana
Trastuzumab-induced hepatotoxicity.
The Annals of pharmacotherapy 2008;42(10):1497-501.
2008: Marcia I Dawson; Zebin Xia; Tao Jiang; Mao Ye; Joseph A Fontana; Lulu Farhana; Bhaumik B Patel; Li Ping Xue; Mohammad Bhuiyan; Roberto Pellicciari; Antonio Macchiarulo; Roberto Nuti; Xiao-kun Zhang; Young-Hoon Han; Lutz Tautz; Peter D Hobbs; Ling Jong; Nahid Waleh; Wan-Ru Chao; Gen-Sheng Feng; Yuhong Pang; Ying Su
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Journal of medicinal chemistry 2008;51(18):5650-62.
2008: Katherine M LaFiura; H Edwards; Jeffrey W Taub; Larry H Matherly; Joseph A Fontana; Anwar N Mohamed; Yaddanapudi Ravindranath; Yubin Ge
Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia: a report from the Children's Oncology Group.
Oncogene 2008;27(36):4933-42.
2008: Alton Oliver Sartor; Catherine M Tangen; Maha Hussain; Mario A Eisenberger; Minoti Parab; Joseph A Fontana; Robert A Chapman; Glenn M Mills; Derek Raghavan; E David Crawford
Antiandrogen withdrawal in castrate-refractory prostate cancer: a Southwest Oncology Group trial (SWOG 9426).
Cancer 2008;112(11):2393-400.
2007: Eric J Small; Joseph A Fontana; Nizar M Tannir; Robert S DiPaola; George Wilding; Mark Rubin; Renee Bailey Iacona; Fairooz Kabbinavar
A phase II trial of gefitinib in patients with non-metastatic hormone-refractory prostate cancer.
BJU international 2007;100(4):765-9.
2007: Marcia I Dawson; Zebin Xia; Gang Liu; Mao Ye; Joseph A Fontana; Lulu Farhana; Bhaumik B Patel; Sankari Arumugarajah; Mohammad Bhuiyan; Xiao-kun Zhang; Young-Hoon Han; William B Stallcup; Jun-ichi Fukushi; Tomas Mustelin; Lutz Tautz; Ying Su; Danni L Harris; Nahid Waleh; Peter D Hobbs; Ling Jong; Wan-Ru Chao; Leonard J Schiff; Brahma P Sani
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Journal of medicinal chemistry 2007;50(11):2622-39.
2007: Ulka Nitin Vaishampayan; Maha Hussain; Mousumi Banerjee; Soley Seren; Asfar S Azmi; Joseph A Fontana; Jeffrey D Forman; Michael L Cher; Isaac J Powell; J Edson Pontes; Omer Kucuk
Lycopene and soy isoflavones in the treatment of prostate cancer.
Nutrition and cancer 2007;59(1):1-7.
2007: Lulu Farhana; Marcia I Dawson; Mark Leid; Li Wang; David D Moore; Gang Liu; Zeben Xia; Joseph A Fontana
Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.
Cancer research 2007;67(1):318-25.
2006: Arun K Rishi; Liyue Zhang; Yingjie Yu; Yan Jiang; Jyoti Nautiyal; Anil Wali; Joseph A Fontana; Edi Levi; Adhip N Majumdar
Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor.
The Journal of biological chemistry 2006;281(19):13188-98.
2005: Bhaumik B Patel; Jeffrey D Forman; Joseph A Fontana; Arthur Frazier; Edson Pontes; Ulka Nitin Vaishampayan
A single institution experience with concurrent capecitabine and radiation therapy in weak and/or elderly patients with urothelial cancer.
International journal of radiation oncology, biology, physics 2005;62(5):1332-8.
2005: Lulu Farhana; Marcia I Dawson; Joseph A Fontana
Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation.
Cancer research 2005;65(11):4909-17.
2004: Ulka Nitin Vaishampayan; Joseph A Fontana; Wei Du; Maha Hussain
Phase II trial of estramustine and etoposide in androgen-sensitive metastatic prostate carcinoma.
American journal of clinical oncology 2004;27(6):550-4.
2004: Marcia I Dawson; Danni L Harris; Gang Liu; Peter D Hobbs; Christopher W Lange; Ling Jong; Nathalie Bruey-Sedano; Sharon Y James; Xiao-kun Zhang; Valerie J Peterson; Mark Leid; Lulu Farhana; Arun K Rishi; Joseph A Fontana
Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest.
Journal of medicinal chemistry 2004;47(14):3518-36.
2004: Lulu Farhana; Marcia I Dawson; Ying Huang; Yuxiang Zhang; Arun K Rishi; Kaladhar B Reddy; Robert S Freeman; Joseph A Fontana
Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities.
Oncogene 2004;23(10):1874-84.
2003: Yuxiang Zhang; Marcia I Dawson; Yangmin Ning; Lisa Anne Polin ; Ralph E Parchment; Thomas H Corbett; Anwar N Mohamed; Kai-Chia Feng; Lulu Farhana; Arun K Rishi; Donna Hogge; Mark Leid; Valerie J Peterson; Xiao-kun Zhang; Ramzi M Mohammad; Jin-Song Lu; Cheryl L Willman; Eric VanBuren; Sandra Biggar; Mark Edelstein; David Eilender; Joseph A Fontana
Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog.
Blood 2003;102(10):3743-52.
2003: Arun K Rishi; Liyue Zhang; Madanamohan Boyanapalli; Anil Wali; Ramzi M Mohammad; Yingjie Yu; Joseph A Fontana; James S Hatfield; Marcia I Dawson; Adhip N Majumdar; Uwe Reichert
Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437.
The Journal of biological chemistry 2003;278(35):33422-35.
2003: Joseph A Fontana
Retinoid signaling in breast carcinoma cells.
Cancer investigation 2003;21(2):327-9.
2003: Maha Hussain; David C Smith; Basil F El-Rayes; Wei Du; Ulka Nitin Vaishampayan; Joseph A Fontana; Wael A Sakr; David P Wood Jr
Neoadjuvant docetaxel and estramustine chemotherapy in high-risk/locallyadvanced prostate cancer.
Urology 2003;61(4):774-80.
2003: Maha Hussain; Mousumi Banerjee; Asfar S Azmi; Zora Djuric Longworth; Michael N Pollak; Daniel Doerge; Joseph A Fontana; Sreenivasa R Chinni; Joanne N Davis; Jeffrey D Forman; David P Wood Jr; Omer Kucuk
Soy isoflavones in the treatment of prostate cancer.
Nutrition and cancer 2003;47(2):111-7.
2002: Ulka Nitin Vaishampayan; Joseph A Fontana; Wei Du; Maha Hussain
An active regimen of weekly paclitaxel and estramustine in metastatic androgen-independent prostate cancer.
Urology 2002;60(6):1050-4.
2002: Yuxiang Zhang; Marcia I Dawson; Ramzi M Mohammad; Arun K Rishi; Lulu Farhana; Kai-Chia Feng; Mark Leid; Valerie J Peterson; Xiao-kun Zhang; Mark Edelstein; David Eilander; Sandra Biggar; Nathan Wall; Uwe Reichert; Joseph A Fontana
Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog.
Blood 2002;100(8):2917-25.
2002: Lulu Farhana; Marcia Dawson; Arun K Rishi; Yuxiang Zhang; Eric Van Buren; Charu Trivedi; Uwe Reichert; Guowei Fang; Marc W Kirschner; Joseph A Fontana
Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway.
Cancer research 2002;62(13):3842-9.
2002: Joseph A Fontana; Arun K Rishi
Classical and novel retinoids: their targets in cancer therapy.
Leukemia 2002;16(4):463-72.
2002: Lisa Anne Polin ; Kathryn White; Juiwanna Kushner; Jennifer Paluch; Chiab Simpson; Susan Pugh; Mark Edelstein; Stuart T Hazeldine; Joseph A Fontana; Patricia M LoRusso; Jerome P Horwitz; Thomas H Corbett
Preclinical efficacy evaluations of XK-469: dose schedule, route and cross-resistance behavior in tumor bearing mice.
Investigational new drugs 2002;20(1):13-22.
2001: Marcia I Dawson; Peter D Hobbs; Valerie J Peterson; Mark Leid; C W Lange; Kai-Chia Feng; J Gu; H Li; Siva Kumar Kolluri; Y Zhang; Joseph A Fontana
Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.
Cancer research 2001;61(12):4723-30.
2001: Edgar Ben-Josef; AT Porter; Sue Han; WC Mertens; Paul J Chuba; Joseph A Fontana; Maha Hussain
Neoadjuvant estramustine and etoposide followed by concurrent estramustine and definitive radiotherapy for locally advanced prostate cancer: feasibility and preliminary results.
International journal of radiation oncology, biology, physics 2001;49(3):699-703.
2000: Lulu Farhana; Madanamohan Boyanapalli; S H Tschang; RJ Sun; CK Hsu; Y X Zhang; Joseph A Fontana; Arun K Rishi
Okadaic acid-mediated induction of the c-fos gene in estrogen receptor-negative human breast carcinoma cells utilized, in part, posttranscriptional mechanisms involving adenosine-uridine-rich elements.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(10):541-50.
2000: H Li; Siva Kumar Kolluri; J Gu; Marcia I Dawson; Xihua Cao; Peter D Hobbs; Bingzhen Lin; G Chen; J Lu; Feng Lin; Z Xie; Joseph A Fontana; John C Reed; X Zhang
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.
Science (New York, N.Y.) 2000;289(5482):1159-64.
2000: Zhi-min Shao; Zhen-zhou Shen; Joseph A Fontana; Sanford H Barsky
Genistein's "ER-dependent and independent" actions are mediated through ER pathways in ER-positive breast carcinoma cell lines.
Anticancer research 2000;20(4):2409-16.
2000: Marcia I Dawson; Ling Jong; Peter D Hobbs; D Xiao; Kai-Chia Feng; Wan-Ru Chao; C Pan; Joseph A Fontana; Xiao-kun Zhang
4-[3-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)phenyl]benzoic acid and heterocyclic-bridged analogues are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists.
Bioorganic & medicinal chemistry letters 2000;10(12):1311-3.
2000: Joseph A Fontana; Marcia I Dawson; Mark Leid; Arun K Rishi; Yuxiang Zhang; C A Hsu; Jin-Song Lu; Valerie J Peterson; Ling Jong; Peter D Hobbs; Wan-Ru Chao; B Shroot; Uwe Reichert
Identification of a unique binding protein specific for a novel retinoid inducing cellular apoptosis.
International journal of cancer. Journal international du cancer 2000;86(4):474-9.
2000: Yuxiang Zhang; Arun K Rishi; Marcia I Dawson; R Tschang; Lulu Farhana; Madanamohan Boyanapalli; Uwe Reichert; B Shroot; Eric Van Buren; Joseph A Fontana
S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid.
Cancer research 2000;60(7):2025-32.
1999: Arun K Rishi; RJ Sun; Y Gao; CK Hsu; TM Gerald; MS Sheikh; Marcia I Dawson; Uwe Reichert; B Shroot; A J Fornace; G Brewer; Joseph A Fontana
Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437.
Nucleic acids research 1999;27(15):3111-9.
1999: Fabrice Zeni; Chantal Parent; R Correa; Charles Natanson; B Freeman; Joseph A Fontana; Martha Quezado; Robert L Danner; Yvonne Fitz; S Richmond; Eric Gerstenberger; Steven M Banks; Peter Q Eichacker
ICAM-1 and CD11b inhibition worsen outcome in rats with E. coli pneumonia.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(1):299-307.
1999: Rayudu Gopalakrishna; Usha Gundimeda; Joseph A Fontana; Robert Clarke
Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status.
Cancer letters 1999;136(2):143-51.
1999: Jiong Wu; Zhen-zhou Shen; Jin-Song Lu; M Jiang; Qi-Xia Han; Joseph A Fontana; Sanford H Barsky; Zhi-min Shao
Prognostic role of p27Kip1 and apoptosis in human breast cancer.
British journal of cancer 1999;79(9-10):1572-8.
1999: Yuxiang Zhang; Y Huang; Arun K Rishi; MS Sheikh; B Shroot; Uwe Reichert; M Dawson; GC Poirer; Joseph A Fontana
Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid.
Experimental cell research 1999;247(1):233-40.
1999: JY Liang; Joseph A Fontana; Rao Jaladanki; J V Ordonez; Marcia I Dawson; B Shroot; JF Wilber; Pei Feng
Synthetic retinoid CD437 induces S-phase arrest and apoptosis in human prostate cancer cells LNCaP and PC-3.
The Prostate 1999;38(3):228-36.
1999: Zhi-min Shao; J Li; Jiong Wu; Qi-Xia Han; Zhen-zhou Shen; Joseph A Fontana; Sanford H Barsky
Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis.
Breast cancer research and treatment 1999;53(3):263-9.
1998: Arun K Rishi; M Yu; J J Tsai-Wu; Chandra P Belani; Joseph A Fontana; D L Baker; M Periasamy; Arif Hussain
Gene amplification and transcriptional upregulation of the sarco/endoplasmic reticulum Ca2+ transport ATPase in thapsigargin-resistant hamster smooth muscle cells.
Nucleic acids research 1998;26(19):4529-37.
1998: Y Li; Bingzhen Lin; A Agadir; R Liu; Marcia I Dawson; John C Reed; Joseph A Fontana; Frédéric Bost; Peter D Hobbs; Y Zheng; Guo-quan Chen; B Shroot; Dan Mercola; Xiao-kun Zhang
Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.
Molecular and cellular biology 1998;18(8):4719-31.
1998: Zhi-min Shao; Mary L Alpaugh; Joseph A Fontana; Sanford H Barsky
Genistein inhibits proliferation similarly in estrogen receptor-positive and negative human breast carcinoma cell lines characterized by P21WAF1/CIP1 induction, G2/M arrest, and apoptosis.
Journal of cellular biochemistry 1998;69(1):44-54.
1998: Joseph A Fontana; RJ Sun; Arun K Rishi; Marcia I Dawson; J V Ordónez; Yuxiang Zhang; S H Tschang; Kapil N Bhalla; Z Han; James H Wyche; GC Poirer; MS Sheikh; B Shroot; Uwe Reichert
Overexpression of bcl-2 or bcl-XL fails to inhibit apoptosis mediated by a novel retinoid.
Oncology research 1998;10(6):313-24.
1997: Arun K Rishi; CK Hsu; X S Li; Arif Hussain; TM Gerald; Joseph A Fontana
Transcriptional repression of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 gene mediated by cis elements present in the 3'-untranslated region.
Cancer research 1997;57(22):5129-36.
1997: M Jiang; Zhi-min Shao; Jiong Wu; Jin-Song Lu; L M Yu; Jianda Yuan; Qi-Xia Han; Zhen-zhou Shen; Joseph A Fontana
p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis.
International journal of cancer. Journal international du cancer 1997;74(5):529-34.
1997: C A Hsu; Arun K Rishi; X Su-Li; TM Gerald; Marcia I Dawson; Charles Alan Schiffer; Uwe Reichert; B Shroot; GC Poirer; Joseph A Fontana
Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway.
Blood 1997;89(12):4470-9.
1997: CK Hsu; Arun K Rishi; X S Li; Marcia I Dawson; Uwe Reichert; B Shroot; Joseph A Fontana
Bcl-X(L) expression and its downregulation by a novel retinoid in breast carcinoma cells.
Experimental cell research 1997;232(1):17-24.
1997: Qi-Xia Han; E A Allegretto; Z M Shao; T E Kute; J Ordonez; Seena Aisner; Arun K Rishi; Joseph A Fontana
Elevated expression of retinoic acid receptor-alpha (RAR alpha) in estrogen-receptor-positive breast carcinomas as detected by immunohistochemistry.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 1997;6(1):42-8.
1996: Arun K Rishi; T M Gerald; Zhi-min Shao; X S Li; R G Baumann; Marcia I Dawson; Joseph A Fontana
Regulation of the human retinoic acid receptor alpha gene in the estrogen receptor negative human breast carcinoma cell lines SKBR-3 and MDA-MB-435.
Cancer research 1996;56(22):5246-52.
1996: Z Shao; M Jiang; J Wu; L Yu; Q Han; T Zhang; Z Shen; Joseph A Fontana
Identification of spontaneous programmed cell death during development of human breast cancer.
Oncology reports 1996;3(6):1133-6.
1996: X S Li; Arun K Rishi; Zhi-min Shao; Marcia I Dawson; Ling Jong; B Shroot; Uwe Reichert; J Ordonez; Joseph A Fontana
Posttranscriptional regulation of p21WAF1/CIP1 expression in human breast carcinoma cells.
Cancer research 1996;56(21):5055-62.
1996: Z Shao; L Yu; Z Shen; Joseph A Fontana
Retinoic acid nuclear receptor alpha(RAR alpha) plays a major role in retinoid-mediated inhibition of growth in human breast carcinoma cells.
Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences 1996;11(3):142-6.
1995: Z Shao; Z Shen; Joseph A Fontana
[Expression of the retinoic acid nuclear receptors and retinoid X receptor gene in human breast cancer].
Zhonghua zhong liu za zhi [Chinese journal of oncology] 1995;17(6):425-8.
1995: Arun K Rishi; Zhi-min Shao; R G Baumann; X S Li; M S Sheikh; S Kimura; Nasir Bashirelahi; Joseph A Fontana
Estradiol regulation of the human retinoic acid receptor alpha gene in human breast carcinoma cells is mediated via an imperfect half-palindromic estrogen response element and Sp1 motifs.
Cancer research 1995;55(21):4999-5006.
1995: Zhi-min Shao; Marcia I Dawson; X S Li; Arun K Rishi; M S Sheikh; Qi-Xia Han; J V Ordonez; B Shroot; Joseph A Fontana
p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.
Oncogene 1995;11(3):493-504.
1995: Zhi-min Shao; M S Sheikh; Arun K Rishi; Marcia I Dawson; X S Li; JF Wilber; Pei Feng; Joseph A Fontana
Thyroid hormone enhancement of estradiol stimulation of breast carcinoma proliferation.
Experimental cell research 1995;218(1):1-8.
1994: R Ray; S Sheikh; Joseph A Fontana; D Miller
Human breast-carcinoma cells show correlation in expression of C-myc oncogene and the C-myc binding-protein (mbp-1).
International journal of oncology 1994;5(6):1433-6.
1994: M S Sheikh; X S Li; J C Chen; Zhi-min Shao; J V Ordonez; Joseph A Fontana
Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways.
Oncogene 1994;9(12):3407-15.
1994: X Li; M Sheikh; Z Shao; Sophie Lanzkron; J Chen; Joseph A Fontana
Regulation of pml messenger-RNA expression in human breast-carcinoma cells.
International journal of oncology 1994;5(5):1177-81.
1994: M S Sheikh; Zhi-min Shao; X S Li; M Dawson; A M Jetten; S Wu; BA Conley; Marcel Garcia; H Rochefort; Joseph A Fontana
Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-alpha acquire sensitivity to growth inhibition by retinoids.
The Journal of biological chemistry 1994;269(34):21440-7.
1994: Michael K Hise; N M Mantzouris; J S Lahn; M S Sheikh; Zhi-min Shao; Joseph A Fontana
Low-protein diet regulates a proximal nephron insulin-like growth factor binding protein.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1994;23(6):849-55.
1994: Z Shao; M Sheikh; J Chen; T Kute; S Aisner; L Schnaper; Joseph A Fontana
Expression of the retinoic Acid nuclear receptors (rars) and retinoid x-receptor (rxr) genes in estrogen-receptor positive and negative breast-cancer.
International journal of oncology 1994;4(4):859-63.
1994: M S Sheikh; Zhi-min Shao; J C Chen; X S Li; Arif Hussain; Joseph A Fontana
Expression of estrogen receptors in estrogen receptor-negative human breast carcinoma cells: modulation of epidermal growth factor-receptor (EGF-R) and transforming growth factor alpha (TGF alpha) gene expression.
Journal of cellular biochemistry 1994;54(3):289-98.
1994: X S Li; J C Chen; M S Sheikh; Zhi-min Shao; Joseph A Fontana
Retinoic acid inhibition of insulin-like growth factor I stimulation of c-fos mRNA levels in a breast carcinoma cell line.
Experimental cell research 1994;211(1):68-73.
1994: M S Sheikh; Marcel Garcia; P Pujol; Joseph A Fontana; Henri Rochefort
Why are estrogen-receptor-negative breast cancers more aggressive than the estrogen-receptor-positive breast cancers?
Invasion & metastasis 1994;14(1-6):329-36.
1994: Michael K Hise; N M Mantzouris; J S Lahn; M S Sheikh; Zhi-min Shao; Joseph A Fontana
IGF binding protein 5 and IGF-I receptor regulation in hypophysectomized rat kidneys.
The American journal of physiology 1994;266(1 Pt 2):F147-54.
1994: J C Chen; Zhi-min Shao; M S Sheikh; Arif Hussain; D LeRoith; Charles T Roberts; Joseph A Fontana
Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line.
Journal of cellular physiology 1994;158(1):69-78.
1993: M S Sheikh; Zhi-min Shao; J C Chen; Arif Hussain; A M Jetten; Joseph A Fontana
Estrogen receptor-negative breast cancer cells transfected with the estrogen receptor exhibit increased RAR alpha gene expression and sensitivity to growth inhibition by retinoic acid.
Journal of cellular biochemistry 1993;53(4):394-404.
1993: J Shemer; A Yaron; H Werner; Zhi-min Shao; M S Sheikh; Joseph A Fontana; Derek LeRoith; Charles T Roberts
Regulation of insulin-like growth factor (IGF) binding protein-5 in the T47D human breast carcinoma cell line by IGF-I and retinoic acid.
The Journal of clinical endocrinology and metabolism 1993;77(5):1246-50.
1993: M S Sheikh; Zhi-min Shao; J C Chen; J V Ordonez; Joseph A Fontana
Retinoid modulation of c-myc and max gene expression in human breast carcinoma.
Anticancer research 1993;13(5A):1387-92.
1993: M S Sheikh; Zhi-min Shao; Arif Hussain; Joseph A Fontana
The p53-binding protein MDM2 gene is differentially expressed in human breast carcinoma.
Cancer research 1993;53(14):3226-8.
1993: Michael K Hise; J S Lahn; Zhi-min Shao; N M Mantzouris; Joseph A Fontana
Insulin-like growth factor-I receptor and binding proteins in rat kidney after nephron loss.
Journal of the American Society of Nephrology : JASN 1993;4(1):62-8.
1993: M S Sheikh; Zhi-min Shao; Arif Hussain; J C Chen; Charles T Roberts; D LeRoith; Joseph A Fontana
Retinoic acid and estrogen modulation of insulin-like growth factor binding protein-4 gene expression and the estrogen receptor status of human breast carcinoma cells.
Biochemical and biophysical research communications 1993;193(3):1232-8.
1993: M S Sheikh; Zhi-min Shao; Arif Hussain; David R Clemmons; J C Chen; Charles T Roberts; D LeRoith; Joseph A Fontana
Regulation of insulin-like growth factor-binding-protein-1, 2, 3, 4, 5, and 6: synthesis, secretion, and gene expression in estrogen receptor-negative human breast carcinoma cells.
Journal of cellular physiology 1993;155(3):556-67.
1993: M S Sheikh; Zhi-min Shao; J C Chen; Joseph A Fontana
Differential regulation of matrix Gla protein (MGP) gene expression by retinoic acid and estrogen in human breast carcinoma cells.
Molecular and cellular endocrinology 1993;92(2):153-60.
1992: M S Sheikh; Zhi-min Shao; J C Chen; David R Clemmons; Charles T Roberts; D LeRoith; Joseph A Fontana
Insulin-like growth factor binding protein-5 gene expression is differentially regulated at a post-transcriptional level in retinoic acid-sensitive and resistant MCF-7 human breast carcinoma cells.
Biochemical and biophysical research communications 1992;188(3):1122-30.
1992: W B Butler; Joseph A Fontana
Responses to retinoic acid of tamoxifen-sensitive and -resistant sublines of human breast cancer cell line MCF-7.
Cancer research 1992;52(22):6164-7.
1992: Martin Adamo; Zhi-min Shao; F Lanau; J C Chen; David R Clemmons; Charles T Roberts; Derek LeRoith; Joseph A Fontana
Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line.
Endocrinology 1992;131(4):1858-66.
1992: Joseph A Fontana; C Nervi; Zhi-min Shao; A M Jetten
Retinoid antagonism of estrogen-responsive transforming growth factor alpha and pS2 gene expression in breast carcinoma cells.
Cancer research 1992;52(14):3938-45.
1992: M S Sheikh; Zhi-min Shao; David R Clemmons; D LeRoith; Charles T Roberts; Joseph A Fontana
Identification of the insulin-like growth factor binding proteins 5 and 6 (IGFBP-5 and 6) in human breast cancer cells.
Biochemical and biophysical research communications 1992;183(3):1003-10.
1992: Mario A Eisenberger; Joseph A Fontana
Suramin, an active nonhormonal cytotoxic drug for treatment of prostate cancer: compelling reasons for testing in patients with hormone-refractory breast cancer.
Journal of the National Cancer Institute 1992;84(1):3-5.
1991: Craig D Albright; P M Grimley; Raymond T Jones; Joseph A Fontana; K P Keenan; James Resau
Cell-to-cell communication: a differential response to TGF-beta in normal and transformed (BEAS-2B) human bronchial epithelial cells.
Carcinogenesis 1991;12(11):1993-9.
1991: Joseph A Fontana; A Burrows-Mezu; David R Clemmons; D LeRoith
Retinoid modulation of insulin-like growth factor-binding proteins and inhibition of breast carcinoma proliferation.
Endocrinology 1991;128(2):1115-22.
1990: Craig D Albright; Raymond T Jones; E A Hudson; Joseph A Fontana; BF Trump; James Resau
Transformed human bronchial epithelial cells (BEAS-2B) alter the growth and morphology of normal human bronchial epithelial cells in vitro.
Cell biology and toxicology 1990;6(4):379-98.
1990: B W Needleman; J Choi; A Burrows-Mezu; Joseph A Fontana
Secretion and binding of transforming growth factor beta by scleroderma and normal dermal fibroblasts.
Arthritis and rheumatism 1990;33(5):650-6.
1990: Joseph A Fontana; A B Mezu; B N Cooper; D Miranda
Retinoid modulation of estradiol-stimulated growth and of protein synthesis and secretion in human breast carcinoma cells.
Cancer research 1990;50(7):1997-2002.
1990: Joseph A Fontana; D Miranda; A B Mezu
Retinoic acid inhibition of human breast carcinoma proliferation is accompanied by inhibition of the synthesis of a Mr 39,000 protein.
Cancer research 1990;50(7):1977-82.
1989: T N Spearman; Joseph A Fontana; F R Butcher; J P Durham
Effect of retinoic acid on the phosphorylation of endogenous proteins in HL-60 cells.
Journal of cellular physiology 1989;138(2):349-57.
1988: Gerald L Messerschmidt; R Makuch; F Appelbaum; R S Ungerleider; R Abrams; J O'Donnell; T V Holohan; Joseph A Fontana; D Wright; N P Anagnou
A prospective randomized trial of HLA-matched versus mismatched single-donor platelet transfusions in cancer patients.
Cancer 1988;62(4):795-801.
1988: J S Rogers; A J Murgo; Joseph A Fontana; P C Raich
Chemotherapy for breast cancer decreases plasma protein C and protein S.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(2):276-81.
1988: Joseph A Fontana; P D Hobbs; Marcia I Dawson
Inhibition of mammary carcinoma growth by retinoidal benzoic acid derivatives.
Experimental cell biology 1988;56(5):254-63.
1987: Joseph A Fontana; G Miksis; D M Miranda; J P Durham
Inhibition of human mammary carcinoma cell proliferation by retinoids and intracellular cAMP-elevating compounds.
Journal of the National Cancer Institute 1987;78(6):1107-12.
1987: T F Hogan; W Koss; A J Murgo; R S Amato; Joseph A Fontana; F L VanScoy
Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1987;5(3):382-90.
1987: Joseph A Fontana; G Miksis; J Durham
Elevation of adenylate cyclase activity during leukemic cell differentiation.
Experimental cell research 1987;168(2):487-93.
1987: Joseph A Fontana
Interaction of retinoids and tamoxifen on the inhibition of human mammary carcinoma cell proliferation.
Experimental cell biology 1987;55(3):136-44.
1987: Joseph A Fontana; W Koss; D McDaniel; J Jenkins; W Welton
Histiocytosis X and acute monocytic leukemia. Biologic illustration of the monocyte phagocytic system.
The American journal of medicine 1987;82(1):137-42.
1986: Joseph A Fontana; A Reppucci; J P Durham; D Miranda
Correlation between the induction of leukemic cell differentiation by various retinoids and modulation of protein kinases.
Cancer research 1986;46(5):2468-73.
1986: Joseph A Fontana; J S Rogers; J P Durham
The role of 13 cis-retinoic acid in the remission induction of a patient with acute promyelocytic leukemia.
Cancer 1986;57(2):209-17.
1985: Joseph A Fontana
Chronic myelogenous leukemia.
The West Virginia medical journal 1985;81(12):265-7.
1985: J P Durham; C A Emler; F R Butcher; Joseph A Fontana
Calcium-activated, phospholipid-dependent protein kinase activity and protein phosphorylation in HL60 cells induced to differentiate by retinoic acid.
FEBS letters 1985;185(1):157-61.
1985: Joseph A Fontana; M Munoz; J Durham
Potentiation between intracellular cyclic-AMP-elevating agents and inducers of leukemic cell differentiation.
Leukemia research 1985;9(9):1127-32.
1984: Joseph A Fontana; C Emler; K Ku; J K McClung; F R Butcher; J P Durham
Cyclic AMP-dependent and -independent protein kinases and protein phosphorylation in human promyelocytic leukemia (HL60) cells induced to differentiate by retinoic acid.
Journal of cellular physiology 1984;120(1):49-60.
1984: D G Snustad; W Koss; Joseph A Fontana
Angioimmunoblastic lymphadenopathy with associated selective myeloid hypoplasia.
Cancer 1984;53(10):2129-34.
1983: P C Raich; B K Walker; J S Rogers; V P Subramanian; Joseph A Fontana; J A Knost; B Denning
Combination of vindesine and prednisone in malignant lymphoma and acute leukemia.
Cancer treatment reports 1983;67(5):485-7.
1983: J P Durham; M Ruppert; Joseph A Fontana
Glycosyltransferase activities and the differentiation of human promyelocytic (HL60) cells by retinoic acid and a phorbol ester.
Biochemical and biophysical research communications 1983;110(1):348-55.
1983: D A Colbert; Joseph A Fontana; U Bode; A B Deisseroth
Changes in the translational activity of polyadenylated messenger RNA of HL60 promyelocytic leukemia cells associated with myeloid or macrophage differentiation.
Cancer research 1983;43(1):229-34.
1982: J P Durham; F R Butcher; Joseph A Fontana
A novel protamine kinase activity in human promyelocytic leukemia cells.
Biochemical and biophysical research communications 1982;108(2):840-5.
1982: B K Walker; P C Raich; Joseph A Fontana; V P Subramanian; J S Rogers; J A Knost; B Denning
Phase II study of vindesine in patients with advanced breast cancer.
Cancer treatment reports 1982;66(9):1729-32.
1982: C A Emler; Joseph A Fontana; F R Butcher
Induction of cyclic AMP-dependent phosphorylation in cytosol of differentiating mouse erythroleukemia cell line 179.
FEBS letters 1982;142(2):210-4.
1981: Joseph A Fontana; D A Colbert; A B Deisseroth
Identification of a population of bipotent stem cells in the HL60 human promyelocytic leukemia cell line.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(6):3863-6.
1980: Joseph A Fontana; D G Wright; E Schiffman; B A Corcoran; A B Deisseroth
Development of chemotactic responsiveness in myeloid precursor cells: studies with a human leukemia cell line.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(6):3664-8.
1979: Joseph A Fontana
Radiation recall associated with VP-16-213 therapy.
Cancer treatment reports 1979;63(2):224-5.
1973: Joseph A Fontana; W Lovenberg
Pineal protein kinase: effect of enzymic phosphorylation on actinomycin D binding by, and template activity of, chromatin.
Proceedings of the National Academy of Sciences of the United States of America 1973;70(3):755-8.
1972: Joseph A Fontana; D Picciano; W Lovenberg
The identification and characterization of a cyclic AMP dependent protein kinase on rabbit reticulocyte ribosomes.
Biochemical and biophysical research communications 1972;49(5):1225-32.
1971: Joseph A Fontana; W Lovenberg
A cyclic AMP-dependent protein kinase of the bovine pineal gland.
Proceedings of the National Academy of Sciences of the United States of America 1971;68(11):2787-90.