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AW Ford-Hutchinson

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Denis Riendeau; Michael Percival; Christine Brideau; Stella Charleson; Daniel Dubé; Diane Ethier; Jean-Pierre Falgueyret; Richard W Friesen; Robert Gordon; Gillian Greig; Jocelyne Guay; Joseph Mancini; Marc Ouellet; Elizabeth Wong; Li Jing Xu; S Boyce; Denise visco; Yves Girard; Peppi Prasit; Robert Zamboni; IW Rodger; Michael J Gresser; AW Ford-Hutchinson; Robert N Young; Chi Chung Chan
Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.
D Hamish Wright; AW Ford-Hutchinson; Kris Chadee; Kathleen M Metters
The human prostanoid DP receptor stimulates mucin secretion in LS174T cells.
Per-Johan Jakobsson; Ralf Morgenstern; J Mancini; AW Ford-Hutchinson; Bengt Persson
Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily.

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2001: Denis Riendeau; Michael Percival; Christine Brideau; Stella Charleson; Daniel Dubé; Diane Ethier; Jean-Pierre Falgueyret; Richard W Friesen; Robert Gordon; Gillian Greig; Jocelyne Guay; Joseph Mancini; Marc Ouellet; Elizabeth Wong; Li Jing Xu; S Boyce; Denise visco; Yves Girard; Peppi Prasit; Robert Zamboni; IW Rodger; Michael J Gresser; AW Ford-Hutchinson; Robert N Young; Chi Chung Chan
Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.
The Journal of pharmacology and experimental therapeutics 2001;296(2):558-66.
2000: D Hamish Wright; AW Ford-Hutchinson; Kris Chadee; Kathleen M Metters
The human prostanoid DP receptor stimulates mucin secretion in LS174T cells.
British journal of pharmacology 2000;131(8):1537-45.
2000: Per-Johan Jakobsson; Ralf Morgenstern; J Mancini; AW Ford-Hutchinson; Bengt Persson
Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily.
American journal of respiratory and critical care medicine 2000;161(2 Pt 2):S20-4.
1999: Li Jing Xu; S Boyce; Christine Brideau; Stella Charleson; Wanda Cromlish; Diane Ethier; J Evans; AW Ford-Hutchinson; M J Forrest; Jacques Yves Gauthier; Robert Gordon; Michael J Gresser; Jocelyne Guay; Stacia Kargman; B Kennedy; Yves Leblanc; Serge Leger; Joseph Mancini; Gary P O'Neill; Marc Ouellet; D Patrick; Michael Percival; Hélène Perrier; Peppi Prasit; IW Rodger
Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
The Journal of pharmacology and experimental therapeutics 1999;290(2):551-60.
1999: D Hamish Wright; François Nantel; Kathleen M Metters; AW Ford-Hutchinson
A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor.
European journal of pharmacology 1999;377(1):101-15.
1999: Peppi Prasit; Zhaoyin Wang; Christine Brideau; Li Jing Xu; Stella Charleson; Wanda Cromlish; Diane Ethier; Jilly F Evans; AW Ford-Hutchinson; Jacques Yves Gauthier; Robert Gordon; Jocelyne Guay; Michael J Gresser; Stacia Kargman; B Kennedy; Yves Leblanc; Serge Léger; Joseph Mancini; Gary P O'Neill; Marc Ouellet; Michael Percival; Hélène Perrier; Denis Riendeau; IW Rodger; Robert Zamboni
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
Bioorganic & medicinal chemistry letters 1999;9(13):1773-8.
1999: Kevin R Lynch; Gary P O'Neill; Qingyun Liu; DS Im; Nicole Sawyer; Kathleen M Metters; N Coulombe; Mark Abramovitz; David Figueroa; Zhizhen Zeng; B M Connolly; C Bai; Christopher P Austin; Anne Chateauneuf; Rino Stocco; Gillian Greig; Stacia Kargman; Shelley Hooks Pence; E Hosfield; David L Williams; AW Ford-Hutchinson; CT Caskey; Jilly F Evans
Characterization of the human cysteinyl leukotriene CysLT1 receptor.
Nature 1999;399(6738):789-93.
1999: N Gupta; Donald W Nicholson; AW Ford-Hutchinson
Demonstration of cell-specific phosphorylation of LTC4 synthase.
FEBS letters 1999;449(1):66-70.
1999: Per-Johan Jakobsson; Ralf Morgenstern; J Mancini; AW Ford-Hutchinson; Bengt Persson
Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism.
Protein science : a publication of the Protein Society 1999;8(3):689-92.
1999: N Gupta; M J Greeser; AW Ford-Hutchinson
A random rapid equilibrium mechanism for leukotriene C4 synthase.
Advances in experimental medicine and biology 1999;469():327-32.
1998: H A Baset; AW Ford-Hutchinson; Gary P O'Neill
Molecular cloning and functional expression of a Caenorhabditis elegans aminopeptidase structurally related to mammalian leukotriene A4 hydrolases.
The Journal of biological chemistry 1998;273(43):27978-87.
1998: D Hamish Wright; Kathleen M Metters; Mark Abramovitz; AW Ford-Hutchinson
Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist.
British journal of pharmacology 1998;123(7):1317-24.
1998: N Gupta; Michael J Gresser; AW Ford-Hutchinson
Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase.
Biochimica et biophysica acta 1998;1391(2):157-68.
1997: N Gupta; Donald W Nicholson; AW Ford-Hutchinson
Pharmacological cross-reactivity between 5-lipoxygenase-activating protein, 5-lipoxygenase, and leukotriene C4 synthase.
Canadian journal of physiology and pharmacology 1997;75(10-11):1212-9.
1997: PJ Jakobsson; Joseph A Mancini; Denis Riendeau; AW Ford-Hutchinson
Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.
The Journal of biological chemistry 1997;272(36):22934-9.
1997: PJ Jakobsson; K A Scoggan; J Yergey; Joseph A Mancini; AW Ford-Hutchinson
Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer.
Journal of lipid mediators and cell signalling 1997;17(1):15-9.
1997: Denis Riendeau; Michael Percival; S Boyce; Christine Brideau; Stella Charleson; Wanda Cromlish; Diane Ethier; J Evans; Jean-Pierre Falgueyret; AW Ford-Hutchinson; Robert Gordon; Gillian Greig; Michael J Gresser; Jocelyne Guay; Stacia Kargman; Serge Léger; Joseph A Mancini; Gary O'Neill; Marc Ouellet; IW Rodger; Michel Thérien; Zhaoyin Wang; J K Webb; Elizabeth Wong; Li Jing Xu
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
British journal of pharmacology 1997;121(1):105-17.
1997: K A Scoggan; PJ Jakobsson; AW Ford-Hutchinson
Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes.
The Journal of biological chemistry 1997;272(15):10182-7.
1997: AW Ford-Hutchinson
Regulation of the biosynthesis of the sulphido-leukotrienes.
Advances in experimental medicine and biology 1997;400B():841-7.
1996: P J Jakobsson; J A Mancini; AW Ford-Hutchinson
Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase.
The Journal of biological chemistry 1996;271(36):22203-10.
1996: K A Scoggan; Donald W Nicholson; AW Ford-Hutchinson
Regulation of leukotriene-biosynthetic enzymes during differentiation of myelocytic HL-60 cells to eosinophilic or neutrophilic cells.
European journal of biochemistry / FEBS 1996;239(3):572-8.
1995: Chun Sing Li; W Cameron Black; Chi Chung Chan; AW Ford-Hutchinson; Jacques Yves Gauthier; Robert Gordon; Daniel Guay; Stacia Kargman; Cheuk K Lau; J Mancini
Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives.
Journal of medicinal chemistry 1995;38(25):4897-905.
1995: P M Brown; Philip Tagari; K R Rowan; V L Yu; Gary P O'Neill; C Russell Middaugh; G Sanyal; AW Ford-Hutchinson; Donald W Nicholson
Epitope-labeled soluble human interleukin-5 (IL-5) receptors. Affinity cross-link labeling, IL-5 binding, and biological activity.
The Journal of biological chemistry 1995;270(49):29236-43.
1995: K A Scoggan; AW Ford-Hutchinson; Donald W Nicholson
Differential activation of leukotriene biosynthesis by granulocyte-macrophage colony-stimulating factor and interleukin-5 in an eosinophilic substrain of HL-60 cells.
Blood 1995;86(9):3507-16.
1995: Chi Chung Chan; S Boyce; Christine Brideau; AW Ford-Hutchinson; Robert Gordon; D Guay; R G Hill; Chun Sing Li; J Mancini; M Penneton
Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1531-7.
1995: H Abdel Baset; Gary P O'Neill; AW Ford-Hutchinson
Characterization of arachidonic-acid-metabolizing enzymes in adult Schistisoma mansoni.
Molecular and biochemical parasitology 1995;73(1-2):31-41.
1995: R Petric; AW Ford-Hutchinson
Inhibition of leukotriene biosynthesis improves renal function in experimental glomerulonephritis.
Journal of lipid mediators and cell signalling 1995;11(3):231-40.
1995: P E Christie; J L Yntema; Philip Tagari; H Ysselstijn; AW Ford-Hutchinson; T H Lee
Effect of altitude on urinary leukotriene (LT) E4 excretion and airway responsiveness to histamine in children with atopic asthma.
The European respiratory journal 1995;8(3):357-63.
1995: Allan B Becker; C Black; M K Lilley; K Bajwa; AW Ford-Hutchinson; F E Simons; Philip Tagari
Antiasthmatic effects of a leukotriene biosynthesis inhibitor (MK-0591) in allergic dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1995;78(2):615-22.
1995: Tom R Jones; M Labelle; M Belley; E Champion; L Charette; J Evans; AW Ford-Hutchinson; Jacques Yves Gauthier; A Lord; P Masson
Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist.
Canadian journal of physiology and pharmacology 1995;73(2):191-201.
1995: R Petric; Donald W Nicholson; AW Ford-Hutchinson
Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis.
Biochimica et biophysica acta 1995;1254(2):207-15.
1995: AW Ford-Hutchinson
Leukotriene antagonists and inhibitors: clinical applications.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():69-74.
1995: A Ali; D W Nicholson; AW Ford-Hutchinson
Characterization of human LTC4 synthase.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():171-3.
1994: AW Ford-Hutchinson
Regulation of leukotriene biosynthesis.
Cancer metastasis reviews 1994;13(3-4):257-67.
1994: AW Ford-Hutchinson
Leukotriene C4 synthase and 5-lipoxygenase activating protein. Regulators of the biosynthesis of sulfido-leukotrienes.
Annals of the New York Academy of Sciences 1994;744():78-83.
1994: R Petric; AW Ford-Hutchinson
Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis.
Kidney international 1994;46(5):1322-9.
1994: A Ali; AW Ford-Hutchinson; Donald W Nicholson
Activation of protein kinase C down-regulates leukotriene C4 synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic substrain of HL-60 cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):776-88.
1994: P E Christie; Philip Tagari; AW Ford-Hutchinson; C Black; A Markendorf; M Schmitz-Schumann; T H Lee
Increased urinary LTE4 excretion following inhalation of LTC4 and LTE4 in asthmatic subjects.
The European respiratory journal 1994;7(5):907-13.
1994: AW Ford-Hutchinson; Michael J Gresser; Robert N Young
5-Lipoxygenase.
Annual review of biochemistry 1994;63():383-417.
1994: AW Ford-Hutchinson
5-Lipoxygenase activating protein and leukotriene C4 synthase: therapeutic targets for inhibiting the leukotriene cascade.
Advances in prostaglandin, thromboxane, and leukotriene research 1994;22():13-21.
1993: AW Ford-Hutchinson; Philip Tagari; S V Ching; C A Anderson; John B Coleman; C P Peter
Chronic leukotriene inhibition in the rat fails to modify the toxicological effects of a cyclooxygenase inhibitor.
Canadian journal of physiology and pharmacology 1993;71(10-11):806-10.
1993: Gary P O'Neill; AW Ford-Hutchinson
Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues.
FEBS letters 1993;330(2):156-60.
1993: Philip Tagari; Christine Brideau; C Chan; R Frenette; C Black; AW Ford-Hutchinson
Assessment of the in vivo biochemical efficacy of orally active leukotriene biosynthesis inhibitors.
Agents and actions 1993;40(1-2):62-71.
1993: Philip Tagari; A Becker; Christine Brideau; R Frenette; V Sadl; E Thomas; PJ Vickers; AW Ford-Hutchinson
Leukotriene generation and metabolism in dogs: inhibition of biosynthesis by MK-0591.
The Journal of pharmacology and experimental therapeutics 1993;265(1):416-25.
1993: A Ali; Robert Zamboni; AW Ford-Hutchinson; Donald W Nicholson
Photoaffinity labelling of human leukotriene C4 synthase in THP-1 cell membranes.
FEBS letters 1993;317(3):195-201.
1993: Philip Tagari; E I Pecheur; M Scheid; P Brown; AW Ford-Hutchinson; D Nicholson
Activation of human eosinophils and differentiated HL-60 cells by interleukin-5.
International archives of allergy and immunology 1993;101(3):227-33.
1993: AW Ford-Hutchinson
Leukotriene antagonists and inhibitors as modulators of IgE-mediated reactions.
Springer seminars in immunopathology 1993;15(1):37-50.
1993: AW Ford-Hutchinson
5-Lipoxygenase activation in psoriasis: a dead issue?
Skin pharmacology : the official journal of the Skin Pharmacology Society 1993;6(4):292-7.
1992: P E Christie; Philip Tagari; AW Ford-Hutchinson; C Black; A Markendorf; M Schmitz-Schumann; T H Lee
Urinary leukotriene E4 after lysine-aspirin inhalation in asthmatic subjects.
The American review of respiratory disease 1992;146(6):1531-4.
1992: Philip Tagari; P Chee; C Chan; K McKee; C Black; D Nicholson; AW Ford-Hutchinson
Quantitation of eosinophil Major Basic Protein cytotoxicity to rodent respiratory epithelium.
Agents and actions 1992;37(3-4):171-3.
1992: Donald W Nicholson; M W Klemba; Dita M Rasper; Kathleen M Metters; Robert Zamboni; AW Ford-Hutchinson
Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells.
European journal of biochemistry / FEBS 1992;209(2):725-34.
1992: Donald W Nicholson; A Ali; M W Klemba; N A Munday; Robert Zamboni; AW Ford-Hutchinson
Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells.
The Journal of biological chemistry 1992;267(25):17849-57.
1992: M Cirino; C Motz; J Maw; AW Ford-Hutchinson; M Yano
BQ-153, a novel endothelin (ET)A antagonist, attenuates the renal vascular effects of endothelin-1.
The Journal of pharmacy and pharmacology 1992;44(9):782-5.
1992: Christine Brideau; C Chan; Stella Charleson; Danielle Denis; Jilly F Evans; AW Ford-Hutchinson; R Fortin; J W Gillard; Jocelyne Guay; D Guévremont
Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.
Canadian journal of physiology and pharmacology 1992;70(6):799-807.
1992: Stella Charleson; Peppi Prasit; Serge Léger; J W Gillard; PJ Vickers; J A Mancini; P Charleson; Jocelyne Guay; AW Ford-Hutchinson; Jilly F Evans
Characterization of a 5-lipoxygenase-activating protein binding assay: correlation of affinity for 5-lipoxygenase-activating protein with leukotriene synthesis inhibition.
Molecular pharmacology 1992;41(5):873-9.
1992: Cheuk K Lau; P C Bélanger; C Dufresne; J Scheigetz; M Therien; B Fitzsimmons; Robert N Young; AW Ford-Hutchinson; Denis Riendeau; Danielle Denis
Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.
Journal of medicinal chemistry 1992;35(7):1299-318.
1992: AW Ford-Hutchinson
Activation of leukotriene production in granulocytes: effects on cell activation.
Immunology series 1992;57():87-106.
1992: M Carry; V Korley; J T Willerson; L Weigelt; AW Ford-Hutchinson; Philip Tagari
Increased urinary leukotriene excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation.
Circulation 1992;85(1):230-6.
1991: Tom R Jones; Robert Zamboni; M Belley; E Champion; L Charette; AW Ford-Hutchinson; Jacques Yves Gauthier; S Leger; A Lord; P Masson
Pharmacology of the leukotriene antagonist verlukast: the (R)-enantiomer of MK-571.
Canadian journal of physiology and pharmacology 1991;69(12):1847-54.
1991: gordon bernard; V Korley; P Chee; Bridget B Swindell; AW Ford-Hutchinson; Philip Tagari
Persistent generation of peptido leukotrienes in patients with the adult respiratory distress syndrome.
The American review of respiratory disease 1991;144(2):263-7.
1991: P E Christie; Philip Tagari; AW Ford-Hutchinson; S Charlesson; P Chee; J P Arm; Tak H Lee
Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects.
The American review of respiratory disease 1991;143(5 Pt 1):1025-9.
1991: Kathleen M Metters; E A Frey; AW Ford-Hutchinson
Characterization of the leukotriene D4 receptor in hyperreactive rat lung.
European journal of pharmacology 1991;194(1):51-61.
1991: AW Ford-Hutchinson
FLAP: a novel drug target for inhibiting the synthesis of leukotrienes.
Trends in pharmacological sciences 1991;12(2):68-70.
1991: AW Ford-Hutchinson
Inhibition of leukotriene biosynthesis.
Annals of the New York Academy of Sciences 1991;629():133-42.
1991: AW Ford-Hutchinson
Arachidonate 15-lipoxygenase; characteristics and potential biological significance.
Eicosanoids 1991;4(2):65-74.
1991: AW Ford-Hutchinson
Innovations in drug research: inhibitors of thromboxane and leukotrienes.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1991;21 Suppl 1():272-6.
1991: AW Ford-Hutchinson
Regulation of the production and action of leukotrienes by MK-571 and MK-886.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():9-16.
1990: Chi Chung Chan; K McKee; Philip Tagari; P Chee; AW Ford-Hutchinson
Eosinophil-eicosanoid interactions: inhibition of eosinophil chemotaxis in vivo by a LTD4-receptor antagonist.
European journal of pharmacology 1990;191(3):273-80.
1990: Jacques Yves Gauthier; T Jones; E Champion; L Charette; R Dehaven; AW Ford-Hutchinson; K Hoogsteen; A Lord; P Masson; Hanna Piechuta
Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl] [[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist.
Journal of medicinal chemistry 1990;33(10):2841-5.
1990: Philip Tagari; William W Abraham; J McGolrick; Stella Charleson; M Soler; A Ahmed; A Cortez; AW Ford-Hutchinson
Increased leukotriene E4 excretion during antigen-induced bronchoconstriction in allergic sheep.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;68(4):1321-7.
1990: Michèle Doucet; Tom R Jones; AW Ford-Hutchinson
Responses of equine trachealis and lung parenchyma to methacholine, histamine, serotonin, prostanoids, and leukotrienes in vitro.
Canadian journal of physiology and pharmacology 1990;68(3):379-83.
1990: C A Rouzer; AW Ford-Hutchinson; H E Morton; J W Gillard
MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes.
The Journal of biological chemistry 1990;265(3):1436-42.
1990: D K Miller; J W Gillard; PJ Vickers; S Sadowski; Claire Léveillé; J A Mancini; P Charleson; R A Dixon; AW Ford-Hutchinson; R Fortin
Identification and isolation of a membrane protein necessary for leukotriene production.
Nature 1990;343(6255):278-81.
1990: Philip Tagari; Diane Ethier; AW Ford-Hutchinson; M Cirino
Application of reversed phase high performance liquid chromatography to the analysis of sulphidopeptide leukotrienes in pig bile.
Biomedical chromatography : BMC 1990;4(1):39-42.
1990: M Cirino; H Morton; C MacDonald; J Hadden; AW Ford-Hutchinson
Thromboxane A2 and prostaglandin endoperoxide analogue effects on porcine renal blood flow.
The American journal of physiology 1990;258(1 Pt 2):F109-14.
1990: Philip Tagari; J B Rasmussen; D Delorme; Yves Girard; L O Eriksson; Stella Charleson; AW Ford-Hutchinson
Comparison of urinary leukotriene E4 and 16-carboxytetranordihydro leukotriene E4 excretion in allergic asthmatics after inhaled antigen.
Eicosanoids 1990;3(2):75-80.
1990: AW Ford-Hutchinson
Modification of the lipoxygenase pathway of arachidonic acid metabolism.
Advances in prostaglandin, thromboxane, and leukotriene research 1990;20():161-9.
1989: AW Ford-Hutchinson; Yves Girard; A Lord; Tom R Jones; M Cirino; Jilly F Evans; J Gillard; Pierre Hamel; Claire Léveillé; P Masson
The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist.
Canadian journal of physiology and pharmacology 1989;67(9):989-93.
1989: Chi Chung Chan; F Dagenais; P Firby; A Foster; AW Ford-Hutchinson
Immediate hypersensitivity reactions in the guinea-pig conjunctiva: studies with a second-generation leukotriene D4 receptor antagonist, MK-571.
Canadian journal of physiology and pharmacology 1989;67(8):845-50.
1989: J Gillard; AW Ford-Hutchinson; C Chan; Stella Charleson; Danielle Denis; A Foster; R Fortin; S Leger; C S McFarlane; H Morton
L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.
Canadian journal of physiology and pharmacology 1989;67(5):456-64.
1989: AW Ford-Hutchinson
The use of leukotriene D4 receptor antagonists and 5-lipoxygenase inhibitors to define a role for leukotrienes in allergic reactions.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():507-10.
1989: Tom R Jones; Robert Zamboni; M Belley; E Champion; L Charette; AW Ford-Hutchinson; R Frenette; Jacques Yves Gauthier; S Leger; P Masson
Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist.
Canadian journal of physiology and pharmacology 1989;67(1):17-28.
1988: R Hamel; AW Ford-Hutchinson; C Blazejczak; A Van den Brekel
Tachykinin involvement in cutaneous anaphylaxis in the guinea pig.
Canadian journal of physiology and pharmacology 1988;66(11):1361-7.
1988: R Hamel; AW Ford-Hutchinson
Contractile activity of calcitonin gene-related peptide on pulmonary tissues.
The Journal of pharmacy and pharmacology 1988;40(3):210-1.
1987: P Belanger; A Maycock; Y Guindon; T Bach; A L Dollob; C Dufresne; AW Ford-Hutchinson; P H Gale; S Hopple; Cheuk K Lau
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor.
Canadian journal of physiology and pharmacology 1987;65(12):2441-8.
1987: D Garceau; AW Ford-Hutchinson; S Charleson
5-Lipoxygenase inhibitors and allergic conjunctivitis reactions in the guinea-pig.
European journal of pharmacology 1987;143(1):1-7.
1987: C S McFarlane; R Hamel; AW Ford-Hutchinson
Effects of a 5-lipoxygenase inhibitor (L-651,392) on primary and late pulmonary responses to ascaris antigen in the squirrel monkey.
Agents and actions 1987;22(1-2):63-8.
1987: H Piechuta; AW Ford-Hutchinson; L G Letts
Inhibition of allergen-induced bronchoconstriction in hyperreactive rats as a model for testing 5-lipoxygenase inhibitors and leukotriene D4 receptor antagonists.
Agents and actions 1987;22(1-2):69-74.
1987: R Hamel; AW Ford-Hutchinson; Hanna Piechuta
Studies on the anti-allergic action of N-(3',4'-dimethoxycinnamoyl) anthranilic acid (N-5').
Allergy 1987;42(4):284-90.
1987: R A Hall; J R Rokach; P Bélanger; L Bianchi; Diane Ethier; AW Ford-Hutchinson; Yves Girard; Pierre Hamel; R Hamel; A Lord
L-641,953 (R-8-fluoro-dibenzo[b, f]thiepin-3-carboxylic acid-5-oxide): a novel thromboxane-prostaglandin endoperoxide antagonist.
Canadian journal of physiology and pharmacology 1987;65(4):509-14.
1987: R A Hall; J Gillard; Y Guindon; G Letts; E Champion; Diane Ethier; J Evans; AW Ford-Hutchinson; R Fortin; Tom R Jones
Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpro pan oic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist.
European journal of pharmacology 1987;135(2):193-201.
1987: L G Letts; C McFarlane; H Piechuta; AW Ford-Hutchinson
Effects of a 5-lipoxygenase inhibitor (L-651,392) and leukotriene D4 antagonist (L-649,923) in two animal models of immediate hypersensitivity reactions.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17B():1007-11.
1987: Robert N Young; Tom R Jones; J G Atkinson; P Bélanger; E Champion; Danielle Denis; R N DeHaven; AW Ford-Hutchinson; R Fortin; R Frenette
Novel arylthio- and arylsulfonylpropyloxyacetophenones: design and synthesis of L-648,051 and L-649,923, potent antagonists of leukotriene D4.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():544-8.
1987: Tom R Jones; Y Guindon; E Champion; L Charette; R N DeHaven; Danielle Denis; Diane Ethier; AW Ford-Hutchinson; R Fortin; R Frenette
L-648,051: an aerosol active leukotriene D4 receptor antagonist.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17B():1012-7.
1987: Y Guindon; Yves Girard; A Maycock; AW Ford-Hutchinson; J G Atkinson; P C Bélanger; aimee dallob; D DeSousa; H Dougherty; R Egan
L-651,392: a novel, potent and selective 5-lipoxygenase inhibitor.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():554-7.
1987: D Garceau; AW Ford-Hutchinson
Role of leukotrienes in allergen-induced vascular permeability changes in the guinea-pig conjunctiva.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17A():167-70.
1986: R Hamel; C S McFarlane; AW Ford-Hutchinson
Late pulmonary responses induced by Ascaris allergen in conscious squirrel monkeys.
Journal of applied physiology (Bethesda, Md. : 1985) 1986;61(6):2081-7.
1986: Tom R Jones; Y Guindon; R Young; E Champion; L Charette; Danielle Denis; Diane Ethier; R Hamel; AW Ford-Hutchinson; R Fortin
L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)- propylsulfonyl]-gamma-oxo-benzenebutanoate: a leukotriene D4 receptor antagonist.
Canadian journal of physiology and pharmacology 1986;64(12):1535-42.
1986: Stella Charleson; Jilly F Evans; Robert Zamboni; Yves Leblanc; B J Fitzsimmons; Claire Léveillé; P Dupuis; AW Ford-Hutchinson
Leukotriene B3, leukotriene B4 and leukotriene B5; binding to leukotriene B4 receptors on rat and human leukocyte membranes.
Prostaglandins 1986;32(4):503-16.
1986: Robert N Young; P Bélanger; E Champion; R N DeHaven; Danielle Denis; AW Ford-Hutchinson; R Fortin; R Frenette; Jacques Yves Gauthier; J Gillard
Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4.
Journal of medicinal chemistry 1986;29(9):1573-6.
1986: Tom R Jones; R Young; E Champion; L Charette; Danielle Denis; AW Ford-Hutchinson; R Frenette; Jacques Yves Gauthier; Y Guindon; M Kakushima
L-649,923, sodium (beta S*, gamma R*)-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propylthio)- gamma-hydroxy-beta-methylbenzenebutanoate, a selective, orally active leukotriene receptor antagonist.
Canadian journal of physiology and pharmacology 1986;64(8):1068-75.
1986: Robert N Young; Y Guindon; Tom R Jones; AW Ford-Hutchinson; P Bélanger; E Champion; L Charette; R N DeHaven; Danielle Denis; R Fortin
L-649,923, sodium (beta S*, gamma R*-4-(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propylthio)-gamma-hydroxy -beta-methylbenzenebutanoate. A selective, orally active leukotriene D4 receptor antagonist.
Advances in prostaglandin, thromboxane, and leukotriene research 1986;16():37-45.
1985: J Evans; Robert Zamboni; D Nathaniel; Claire Léveillé; AW Ford-Hutchinson
Characterization of biological properties of synthetic and biological leukotriene B3.
Prostaglandins 1985;30(6):981-8.
1985: D J Nathaniel; Jilly F Evans; Yves Leblanc; Claire Léveillé; B J Fitzsimmons; AW Ford-Hutchinson
Leukotriene A5 is a substrate and an inhibitor of rat and human neutrophil LTA4 hydrolase.
Biochemical and biophysical research communications 1985;131(2):827-35.
1985: Jilly F Evans; D J Nathaniel; Robert Zamboni; AW Ford-Hutchinson
Leukotriene A3. A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase.
The Journal of biological chemistry 1985;260(20):10966-70.
1985: L G Letts; M Cirino; P Yusko; B Fitzsimmons; AW Ford-Hutchinson; J Rokach
Actions of synthetic leukotrienes on platelets and blood vessels in the anesthetised pig: the release of a platelet derived vasodilator.
Prostaglandins 1985;29(6):1049-62.
1985: AW Ford-Hutchinson; R Hamel; C S McFarlane
Pulmonary responses to exogenous leukotrienes.
Progress in clinical and biological research 1985;199():199-207.
1984: J Evans; AW Ford-Hutchinson; B Fitzsimmons; J Rokach
Biological activities of isomers of 8,15-dihydroxyeicosatetraenoic acid.
Prostaglandins 1984;28(3):435-8.
1984: C S McFarlane; Hanna Piechuta; R A Hall; AW Ford-Hutchinson
Effects of a contractile prostaglandin antagonist (L-640,035) upon allergen-induced bronchoconstriction in hyperreactive rats and conscious squirrel monkeys.
Prostaglandins 1984;28(2):173-82.
1984: R Hamel; AW Ford-Hutchinson; A Lord; M Cirino
Bronchoconstriction induced by N-formyl-methionyl-leucyl-phenylalanine in the guinea pig; involvement of arachidonic acid metabolites.
Prostaglandins 1984;28(1):43-56.
1984: R Carrier; E J Cragoe; Diane Ethier; AW Ford-Hutchinson; Yves Girard; R A Hall; Pierre Hamel; J Rokach; N N Share; C A Stone
Studies on L-640,035: a novel antagonist of contractile prostanoids in the lung.
British journal of pharmacology 1984;82(2):389-95.
1983: G Brunet; Hanna Piechuta; R Hamel; G Holme; AW Ford-Hutchinson
Respiratory responses to leukotrienes and biogenic amines in normal and hyperreactive rats.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(1):434-8.
1982: Danielle Denis; Stella Charleson; A Rackham; Tom R Jones; AW Ford-Hutchinson; A Lord; M Cirino; Yves Girard; M Larue; J Rokach
Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone.
Prostaglandins 1982;24(6):801-14.
1982: R Hamel; P Masson; AW Ford-Hutchinson; Tom R Jones; G Brunet; Hanna Piechuta
Differing mechanisms for leukotriene d4-induced bronchoconstriction in guinea pigs following intravenous and aerosol administration.
Prostaglandins 1982;24(3):419-32.