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Michael Forgac

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TOP 3
Masashi Toei; Satoko Toei; Michael Forgac
Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPase.
Masashi Toei; Regina Saum; Michael Forgac
Regulation and isoform function of the V-ATPases.
Katie M O'Callaghan; Veronica Ayllon; Jean O'Keeffe; Yanru Wang; Orla T Cox; Gary Loughran; Michael Forgac; Rosemary O'Connor
Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.

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All Publications

2011: Masashi Toei; Satoko Toei; Michael Forgac
Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPase.
The Journal of biological chemistry 2011;286(40):35176-86.
2010: Masashi Toei; Regina Saum; Michael Forgac
Regulation and isoform function of the V-ATPases.
Biochemistry 2010;49(23):4715-23.
2010: Katie M O'Callaghan; Veronica Ayllon; Jean O'Keeffe; Yanru Wang; Orla T Cox; Gary Loughran; Michael Forgac; Rosemary O'Connor
Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.
The Journal of biological chemistry 2010;285(1):381-91.
2009: Ayana Hinton; Souad R Sennoune; Sarah Bond; Min Fang; Moshe Reuveni; G Gary Sahagian; Daniel Jay; Raul Martinez-Zaguilan; Michael Forgac
Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells.
The Journal of biological chemistry 2009;284(24):16400-8.
2009: Ayana Hinton; Sarah Bond; Michael Forgac
V-ATPase functions in normal and disease processes.
Pflügers Archiv : European journal of physiology 2009;457(3):589-98.
2008: Kevin C Jefferies; Daniel J Cipriano; Michael Forgac
Function, structure and regulation of the vacuolar (H+)-ATPases.
Archives of biochemistry and biophysics 2008;476(1):33-42.
2008: Yanru Wang; Masashi Toei; Michael Forgac
Analysis of the membrane topology of transmembrane segments in the C-terminal hydrophobic domain of the yeast vacuolar ATPase subunit a (Vph1p) by chemical modification.
The Journal of biological chemistry 2008;283(30):20696-702.
2008: Jie Qi; Michael Forgac
Function and subunit interactions of the N-terminal domain of subunit a (Vph1p) of the yeast V-ATPase.
The Journal of biological chemistry 2008;283(28):19274-82.
2008: Daniel J Cipriano; Yanru Wang; Sarah Bond; Ayana Hinton; Kevin C Jefferies; Jie Qi; Michael Forgac
Structure and regulation of the vacuolar ATPases.
Biochimica et biophysica acta 2008;1777(7-8):599-604.
2008: Kevin C Jefferies; Michael Forgac
Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F.
The Journal of biological chemistry 2008;283(8):4512-9.
2007: Shoko Kawasaki-Nishi; Akihito Yamaguchi; Michael Forgac; Tsuyoshi Nishi
Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit.
Biochemical and biophysical research communications 2007;364(4):1032-6.
2007: Jie Qi; Yanru Wang; Michael Forgac
The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation.
Journal of bioenergetics and biomembranes 2007;39(5-6):423-6.
2007: Yanru Wang; Daniel J Cipriano; Michael Forgac
Arrangement of subunits in the proteolipid ring of the V-ATPase.
The Journal of biological chemistry 2007;282(47):34058-65.
2007: Michael Forgac
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology.
Nature reviews. Molecular cell biology 2007;8(11):917-29.
2007: Jie Qi; Michael Forgac
Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity.
The Journal of biological chemistry 2007;282(34):24743-51.
2006: Zhenyu Zhang; Takao Inoue; Michael Forgac; Stephan Wilkens
Localization of subunit C (Vma5p) in the yeast vacuolar ATPase by immuno electron microscopy.
FEBS letters 2006;580(8):2006-10.
2005: Yanru Wang; Takao Inoue; Michael Forgac
Subunit a of the yeast V-ATPase participates in binding of bafilomycin.
The Journal of biological chemistry 2005;280(49):40481-8.
2005: Takao Inoue; Yanru Wang; Kevin Jefferies; Jie Qi; Ayana Hinton; Michael Forgac
Structure and regulation of the V-ATPases.
Journal of bioenergetics and biomembranes 2005;37(6):393-8.
2005: Takao Inoue; Michael Forgac
Cysteine-mediated cross-linking indicates that subunit C of the V-ATPase is in close proximity to subunits E and G of the V1 domain and subunit a of the V0 domain.
The Journal of biological chemistry 2005;280(30):27896-903.
2005: Ruichao Shen; Takao Inoue; Michael Forgac; John A Porco
Synthesis of photoactivatable acyclic analogues of the lobatamides.
The Journal of organic chemistry 2005;70(9):3686-92.
2004: Elim Shao; Michael Forgac
Involvement of the nonhomologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation.
The Journal of biological chemistry 2004;279(47):48663-70.
2004: Yanru Wang; Takao Inoue; Michael Forgac
TM2 but not TM4 of subunit c'' interacts with TM7 of subunit a of the yeast V-ATPase as defined by disulfide-mediated cross-linking.
The Journal of biological chemistry 2004;279(43):44628-38.
2004: Stephan Wilkens; Takao Inoue; Michael Forgac
Three-dimensional structure of the vacuolar ATPase. Localization of subunit H by difference imaging and chemical cross-linking.
The Journal of biological chemistry 2004;279(40):41942-9.
2003: Tsuyoshi Nishi; Shoko Kawasaki-Nishi; Michael Forgac
Expression and function of the mouse V-ATPase d subunit isoforms.
The Journal of biological chemistry 2003;278(47):46396-402.
2003: Shoko Kawasaki-Nishi; Tsuyoshi Nishi; Michael Forgac
Interacting helical surfaces of the transmembrane segments of subunits a and c' of the yeast V-ATPase defined by disulfide-mediated cross-linking.
The Journal of biological chemistry 2003;278(43):41908-13.
2003: Takao Inoue; Stephan Wilkens; Michael Forgac
Subunit structure, function, and arrangement in the yeast and coated vesicle V-ATPases.
Journal of bioenergetics and biomembranes 2003;35(4):291-9.
2003: Shoko Kawasaki-Nishi; Tsuyoshi Nishi; Michael Forgac
Proton translocation driven by ATP hydrolysis in V-ATPases.
FEBS letters 2003;545(1):76-85.
2003: Elim Shao; Tsuyoshi Nishi; Shoko Kawasaki-Nishi; Michael Forgac
Mutational analysis of the non-homologous region of subunit A of the yeast V-ATPase.
The Journal of biological chemistry 2003;278(15):12985-91.
2003: Tsuyoshi Nishi; Shoko Kawasaki-Nishi; Michael Forgac
The first putative transmembrane segment of subunit c" (Vma16p) of the yeast V-ATPase is not necessary for function.
The Journal of biological chemistry 2003;278(8):5821-7.
2002: Yoichiro Arata; James D Baleja; Michael Forgac
Localization of subunits D, E, and G in the yeast V-ATPase complex using cysteine-mediated cross-linking to subunit B.
Biochemistry 2002;41(37):11301-7.
2002: Yoichiro Arata; Tsuyoshi Nishi; Shoko Kawasaki-Nishi; Elim Shao; Stephan Wilkens; Michael Forgac
Structure, subunit function and regulation of the coated vesicle and yeast vacuolar (H(+))-ATPases.
Biochimica et biophysica acta 2002;1555(1-3):71-4.
2002: Tsuyoshi Nishi; Michael Forgac
The vacuolar (H+)-ATPases--nature's most versatile proton pumps.
Nature reviews. Molecular cell biology 2002;3(2):94-103.
2002: Yoichiro Arata; James D Baleja; Michael Forgac
Cysteine-directed cross-linking to subunit B suggests that subunit E forms part of the peripheral stalk of the vacuolar H+-ATPase.
The Journal of biological chemistry 2002;277(5):3357-63.
2001: Shoko Kawasaki-Nishi; Katherine Bowers; Tsuyoshi Nishi; Michael Forgac; Tom H Stevens
The amino-terminal domain of the vacuolar proton-translocating ATPase a subunit controls targeting and in vivo dissociation, and the carboxyl-terminal domain affects coupling of proton transport and ATP hydrolysis.
The Journal of biological chemistry 2001;276(50):47411-20.
2001: Stephan Wilkens; Michael Forgac
Three-dimensional structure of the vacuolar ATPase proton channel by electron microscopy.
The Journal of biological chemistry 2001;276(47):44064-8.
2001: Shoko Kawasaki-Nishi; Tsuyoshi Nishi; Michael Forgac
Arg-735 of the 100-kDa subunit a of the yeast V-ATPase is essential for proton translocation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12397-402.
2001: Tsuyoshi Nishi; Shoko Kawasaki-Nishi; Michael Forgac
Expression and localization of the mouse homologue of the yeast V-ATPase 21-kDa Subunit c" (Vma16p).
The Journal of biological chemistry 2001;276(36):34122-30.
2001: T Xu; Michael Forgac
Microtubules are involved in glucose-dependent dissociation of the yeast vacuolar [H+]-ATPase in vivo.
The Journal of biological chemistry 2001;276(27):24855-61.
2001: Shoko Kawasaki-Nishi; Tsuyoshi Nishi; Michael Forgac
Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation.
The Journal of biological chemistry 2001;276(21):17941-8.
2000: T Xu; Michael Forgac
Subunit D (Vma8p) of the yeast vacuolar H+-ATPase plays a role in coupling of proton transport and ATP hydrolysis.
The Journal of biological chemistry 2000;275(29):22075-81.
2000: Tsuyoshi Nishi; Michael Forgac
Molecular cloning and expression of three isoforms of the 100-kDa a subunit of the mouse vacuolar proton-translocating ATPase.
The Journal of biological chemistry 2000;275(10):6824-30.
2000: E Vasilyeva; Q Liu; KJ MacLeod; James D Baleja; Michael Forgac
Cysteine scanning mutagenesis of the noncatalytic nucleotide binding site of the yeast V-ATPase.
The Journal of biological chemistry 2000;275(1):255-60.
2000: Michael Forgac
Structure, mechanism and regulation of the clathrin-coated vesicle and yeast vacuolar H(+)-ATPases.
The Journal of experimental biology 2000;203(Pt 1):71-80.
1999: KJ MacLeod; E Vasilyeva; Keith D Merdek; Pia Vogel; Michael Forgac
Photoaffinity labeling of wild-type and mutant forms of the yeast V-ATPase A subunit by 2-azido-[(32)P]ADP.
The Journal of biological chemistry 1999;274(46):32869-74.
1999: Stephan Wilkens; E Vasilyeva; Michael Forgac
Structure of the vacuolar ATPase by electron microscopy.
The Journal of biological chemistry 1999;274(45):31804-10.
1999: T Xu; E Vasilyeva; Michael Forgac
Subunit interactions in the clathrin-coated vesicle vacuolar (H(+))-ATPase complex.
The Journal of biological chemistry 1999;274(41):28909-15.
1999: XH Leng; T Nishi; Michael Forgac
Transmembrane topography of the 100-kDa a subunit (Vph1p) of the yeast vacuolar proton-translocating ATPase.
The Journal of biological chemistry 1999;274(21):14655-61.
1999: Michael Forgac
Structure and properties of the vacuolar (H+)-ATPases.
The Journal of biological chemistry 1999;274(19):12951-4.
1999: Michael Forgac
Structure and properties of the clathrin-coated vesicle and yeast vacuolar V-ATPases.
Journal of bioenergetics and biomembranes 1999;31(1):57-65.
1999: Michael Forgac
The vacuolar H+-ATPase of clathrin-coated vesicles is reversibly inhibited by S-nitrosoglutathione.
The Journal of biological chemistry 1999;274(3):1301-5.
1998: Michael Forgac
Structure, function and regulation of the vacuolar (H+)-ATPases.
FEBS letters 1998;440(3):258-63.
1998: E Vasilyeva; Michael Forgac
Interaction of the clathrin-coated vesicle V-ATPase with ADP and sodium azide.
The Journal of biological chemistry 1998;273(37):23823-9.
1998: XH Leng; M F Manolson; Michael Forgac
Function of the COOH-terminal domain of Vph1p in activity and assembly of the yeast V-ATPase.
The Journal of biological chemistry 1998;273(12):6717-23.
1998: KJ MacLeod; E Vasilyeva; James D Baleja; Michael Forgac
Mutational analysis of the nucleotide binding sites of the yeast vacuolar proton-translocating ATPase.
The Journal of biological chemistry 1998;273(1):150-6.
1997: Q Liu; XH Leng; P R Newman; E Vasilyeva; P M Kane; Michael Forgac
Site-directed mutagenesis of the yeast V-ATPase A subunit.
The Journal of biological chemistry 1997;272(18):11750-6.
1997: Tom H Stevens; Michael Forgac
Structure, function and regulation of the vacuolar (H+)-ATPase.
Annual review of cell and developmental biology 1997;13():779-808.
1996: X H Leng; M F Manolson; Q Liu; Michael Forgac
Site-directed mutagenesis of the 100-kDa subunit (Vph1p) of the yeast vacuolar (H+)-ATPase.
The Journal of biological chemistry 1996;271(37):22487-93.
1996: E Vasilyeva; Michael Forgac
3'-O-(4-Benzoyl)benzoyladenosine 5'-triphosphate inhibits activity of the vacuolar (H+)-ATPase from bovine brain clathrin-coated vesicles by modification of a rapidly exchangeable, noncatalytic nucleotide binding site on the B subunit.
The Journal of biological chemistry 1996;271(22):12775-82.
1996: Q Liu; P M Kane; P R Newman; Michael Forgac
Site-directed mutagenesis of the yeast V-ATPase B subunit (Vma2p).
The Journal of biological chemistry 1996;271(4):2018-22.
1996: Michael Forgac
Regulation of vacuolar acidification.
Society of General Physiologists series 1996;51():121-32.
1995: J Zhang; E Vasilyeva; Y Feng; Michael Forgac
Inhibition and labeling of the coated vesicle V-ATPase by 2-azido-[32P]ATP.
The Journal of biological chemistry 1995;270(26):15494-500.
1994: Q Liu; Y Feng; Michael Forgac
Activity and in vitro reassembly of the coated vesicle (H+)-ATPase requires the 50-kDa subunit of the clathrin assembly complex AP-2.
The Journal of biological chemistry 1994;269(50):31592-7.
1994: J Zhang; Y Feng; Michael Forgac
Proton conduction and bafilomycin binding by the V0 domain of the coated vesicle V-ATPase.
The Journal of biological chemistry 1994;269(38):23518-23.
1994: J Rodman; Y Feng; M Myers; J Zhang; R Magner; Michael Forgac
Comparison of the coated-vesicle and synaptic-vesicle vacuolar (H+)-ATPases.
Annals of the New York Academy of Sciences 1994;733():203-11.
1994: Y Feng; Michael Forgac
Inhibition of vacuolar H(+)-ATPase by disulfide bond formation between cysteine 254 and cysteine 532 in subunit A.
The Journal of biological chemistry 1994;269(18):13224-30.
1993: M Myers; Michael Forgac
Assembly of the peripheral domain of the bovine vacuolar H(+)-adenosine triphosphatase.
Journal of cellular physiology 1993;156(1):35-42.
1993: M Myers; Michael Forgac
The coated vesicle vacuolar (H+)-ATPase associates with and is phosphorylated by the 50-kDa polypeptide of the clathrin assembly protein AP-2.
The Journal of biological chemistry 1993;268(13):9184-6.
1992: Michael Forgac
Structure and properties of the coated vesicle proton pump.
Annals of the New York Academy of Sciences 1992;671():273-83.
1992: Michael Forgac
Structure, function and regulation of the coated vesicle V-ATPase.
The Journal of experimental biology 1992;172():155-69.
1992: Y Feng; Michael Forgac
A novel mechanism for regulation of vacuolar acidification.
The Journal of biological chemistry 1992;267(28):19769-72.
1992: Michael Forgac
Structure and properties of the coated vesicle (H+)-ATPase.
Journal of bioenergetics and biomembranes 1992;24(4):341-50.
1992: Michael Forgac
V-type ATPases. Introduction.
Journal of bioenergetics and biomembranes 1992;24(4):339-40.
1992: J Zhang; M Myers; Michael Forgac
Characterization of the V0 domain of the coated vesicle (H+)-ATPase.
The Journal of biological chemistry 1992;267(14):9773-8.
1992: Y Feng; Michael Forgac
Cysteine 254 of the 73-kDa A subunit is responsible for inhibition of the coated vesicle (H+)-ATPase upon modification by sulfhydryl reagents.
The Journal of biological chemistry 1992;267(9):5817-22.
1992: K Puopolo; M Sczekan; R Magner; Michael Forgac
The 40-kDa subunit enhances but is not required for activity of the coated vesicle proton pump.
The Journal of biological chemistry 1992;267(8):5171-6.
1992: K Puopolo; C Kumamoto; I Adachi; R Magner; Michael Forgac
Differential expression of the "B" subunit of the vacuolar H(+)-ATPase in bovine tissues.
The Journal of biological chemistry 1992;267(6):3696-706.
1991: K Puopolo; C Kumamoto; I Adachi; Michael Forgac
A single gene encodes the catalytic "A" subunit of the bovine vacuolar H(+)-ATPase.
The Journal of biological chemistry 1991;266(36):24564-72.
1991: N Márquez-Sterling; I M Herman; T Pesacreta; H Arai; G Terres; Michael Forgac
Immunolocalization of the vacuolar-type (H+)-ATPase from clathrin-coated vesicles.
European journal of cell biology 1991;56(1):19-33.
1990: K Puopolo; Michael Forgac
Functional reassembly of the coated vesicle proton pump.
The Journal of biological chemistry 1990;265(25):14836-41.
1990: I Adachi; K Puopolo; N Marquez-Sterling; H Arai; Michael Forgac
Dissociation, cross-linking, and glycosylation of the coated vesicle proton pump.
The Journal of biological chemistry 1990;265(2):967-73.
1990: I Adachi; H Arai; R Pimental; Michael Forgac
Proteolysis and orientation on reconstitution of the coated vesicle proton pump.
The Journal of biological chemistry 1990;265(2):960-6.
1989: Michael Forgac
Structure and function of vacuolar class of ATP-driven proton pumps.
Physiological reviews 1989;69(3):765-96.
1989: H Arai; S Pink; Michael Forgac
Interaction of anions and ATP with the coated vesicle proton pump.
Biochemistry 1989;28(7):3075-82.
1988: H Arai; G Terres; S Pink; Michael Forgac
Topography and subunit stoichiometry of the coated vesicle proton pump.
The Journal of biological chemistry 1988;263(18):8796-802.
1987: H Arai; M Berne; G Terres; H Terres; K Puopolo; Michael Forgac
Subunit composition and ATP site labeling of the coated vesicle proton-translocating adenosinetriphosphatase.
Biochemistry 1987;26(21):6632-8.
1987: H Arai; M Berne; Michael Forgac
Inhibition of the coated vesicle proton pump and labeling of a 17,000-dalton polypeptide by N,N'-dicyclohexylcarbodiimide.
The Journal of biological chemistry 1987;262(23):11006-11.
1986: Michael Forgac; M Berne
Structural characterization of the ATP-hydrolyzing portion of the coated vesicle proton pump.
Biochemistry 1986;25(15):4275-80.