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Poh-Gek Forkert

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Poh-Gek Forkert
Mechanisms of lung tumorigenesis by ethyl carbamate and vinyl carbamate.
Lya G Hernandez; Poh-Gek Forkert
Inhibition of vinyl carbamate-induced lung tumors and Kras2 mutations by the garlic derivative diallyl sulfone.
Frederick W K Kan; Poh-Gek Forkert; Michael G Wade
Trichloroethylene exposure elicits damage in epididymal epithelium and spermatozoa in mice.

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All Publications

2010: Poh-Gek Forkert
Mechanisms of lung tumorigenesis by ethyl carbamate and vinyl carbamate.
Drug metabolism reviews 2010;42(2):355-78.
2009: Lya G Hernandez; Poh-Gek Forkert
Inhibition of vinyl carbamate-induced lung tumors and Kras2 mutations by the garlic derivative diallyl sulfone.
Mutation research 2009;662(1-2):16-21.
2007: Frederick W K Kan; Poh-Gek Forkert; Michael G Wade
Trichloroethylene exposure elicits damage in epididymal epithelium and spermatozoa in mice.
Histology and histopathology 2007;22(9):977-88.
2007: Lya G Hernandez; Poh-Gek Forkert
Inhibition of vinyl carbamate-induced mutagenicity and clastogenicity by the garlic constituent diallyl sulfone in F1 (Big Blue x A/J) transgenic mice.
Carcinogenesis 2007;28(8):1824-30.
2007: Poh-Gek Forkert; Martin Kaufmann; Gordon Black; Raymond J Bowers; Heidi Chen; Kathy Collins; Ashish Sharma; Glenville Jones
Oxidation of vinyl carbamate and formation of 1,N6-ethenodeoxyadenosine in murine lung.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(5):713-20.
2007: Lya G Hernandez; Poh-Gek Forkert
In vivo mutagenicity of vinyl carbamate and ethyl carbamate in lung and small intestine of F1 (Big Blue x A/J) transgenic mice.
International journal of cancer. Journal international du cancer 2007;120(7):1426-33.
2006: Gordon P Black; Kathy S Collins; Dylan P Blacquiere; Poh-Gek Forkert
Formation of N-alkylprotoporphyrin IX from metabolism of diallyl sulfone in lung and liver.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(6):895-900.
2006: Poh-Gek Forkert; Brandie Millen; Lawrence H Lash; David A Putt; Burhan I Ghanayem
Pulmonary bronchiolar cytotoxicity and formation of dichloroacetyl lysine protein adducts in mice treated with trichloroethylene.
The Journal of pharmacology and experimental therapeutics 2006;316(2):520-9.
2005: Poh-Gek Forkert; R Michael Baldwin; Brandie Millen; Lawrence H Lash; David A Putt; Michael A Shultz; Kathy S Collins
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1429-37.
2005: Erik J Martin; Poh-Gek Forkert
1,1-Dichloroethylene-induced mitochondrial damage precedes apoptotic cell death of bronchiolar epithelial cells in murine lung.
The Journal of pharmacology and experimental therapeutics 2005;313(1):95-103.
2004: Hongbin Xu; Nongnuj Tanphaichitr; Poh-Gek Forkert; Araya Anupriwan; Wattana Weerachatyanukul; Renaud Vincent; Arthur Leader; Michael G Wade
Exposure to trichloroethylene and its metabolites causes impairment of sperm fertilizing ability in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2004;82(2):590-7.
2004: Andrea C Simmonds; Christopher A Reilly; R Michael Baldwin; Burhan I Ghanayem; Diane L Lanza; Garold S Yost; Kathy S Collins; Poh-Gek Forkert
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(9):1032-9.
2004: Andrea C Simmonds; Burhan I Ghanayem; Ashish Sharma; Christopher A Reilly; Brandie Millen; Garold S Yost; Poh-Gek Forkert
Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung.
The Journal of pharmacology and experimental therapeutics 2004;310(3):855-64.
2004: Erik J Martin; Poh-Gek Forkert
Evidence that 1,1-dichloroethylene induces apoptotic cell death in murine liver.
The Journal of pharmacology and experimental therapeutics 2004;310(1):33-42.
2003: Poh-Gek Forkert; Lawrence H Lash; Robert Tardif; Nongnuj Tanphaichitr; Catherine A VandeVoort; Madeleine Moussa
Identification of trichloroethylene and its metabolites in human seminal fluid of workers exposed to trichloroethylene.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(3):306-11.
2003: Adina Vultur; Evangelia Tomai; Katherine Peebles; Alvin M Malkinson; Nicholas Grammatikakis; Poh-Gek Forkert; Leda Raptis
Gap junctional intercellular communication in cells isolated from urethane-induced tumors in A/J mice.
DNA and cell biology 2003;22(1):33-40.
2003: Erik J Martin; William J Racz; Poh-Gek Forkert
Mitochondrial dysfunction is an early manifestation of 1,1-dichloroethylene-induced hepatotoxicity in mice.
The Journal of pharmacology and experimental therapeutics 2003;304(1):121-9.
2002: Poh-Gek Forkert; Lawrence H Lash; Veronique Nadeau; Robert Tardif; Andrea C Simmonds
Metabolism and toxicity of trichloroethylene in epididymis and testis.
Toxicology and applied pharmacology 2002;182(3):244-54.
2001: Poh-Gek Forkert; S M Boyd
Differential metabolism of 1,1-dichloroethylene in livers of A/J, CD-1, and C57BL/6 mice.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1396-402.
2001: Poh-Gek Forkert; S M Boyd; J B Ulreich
Pulmonary bioactivation of 1,1-dichloroethylene is associated with CYP2E1 levels in A/J, CD-1, and C57BL/6 mice.
The Journal of pharmacology and experimental therapeutics 2001;297(3):1193-200.
2001: Poh-Gek Forkert; RP Lee; K Reid
Involvement of CYP2E1 and carboxylesterase enzymes in vinyl carbamate metabolism in human lung microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(3):258-63.
2001: Poh-Gek Forkert
Mechanisms of 1,1-dichloroethylene-induced cytotoxicity in lung and liver.
Drug metabolism reviews 2001;33(1):49-80.
2001: A P Titis; Poh-Gek Forkert
Strain-related differences in bioactivation of vinyl carbamate and formation of DNA adducts in lungs of A/J, CD-1, and C57BL/6 mice.
Toxicological sciences : an official journal of the Society of Toxicology 2001;59(1):82-91.
2000: Poh-Gek Forkert; P D Premdas; Raymond J Bowers
Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs.
American journal of respiratory cell and molecular biology 2000;23(5):687-95.
2000: Leda Raptis; Kevin L Firth; Evangelia Tomai; Poh-Gek Forkert
Improved procedure for examination of gap junctional intercellular communication by in situ electroporation on a partly conductive slide.
BioTechniques 2000;29(2):222-4, 226.
2000: P D Premdas; Raymond J Bowers; Poh-Gek Forkert
Inactivation of hepatic CYP2E1 by an epoxide of diallyl sulfone.
The Journal of pharmacology and experimental therapeutics 2000;293(3):1112-20.
1999: Poh-Gek Forkert
In vivo formation and localization of 1,1-dichloroethylene epoxide in murine liver: identification of its glutathione conjugate 2-S-glutathionyl acetate.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1299-306.
1999: Poh-Gek Forkert
1,1-Dichloroethylene-induced Clara cell damage is associated with in situ formation of the reactive epoxide. Immunohistochemical detection of its glutathione conjugate.
American journal of respiratory cell and molecular biology 1999;20(6):1310-8.
1999: T F Dowsley; K Reid; Dimitri Petsikas; J B Ulreich; R L Fisher; Poh-Gek Forkert
Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes.
The Journal of pharmacology and experimental therapeutics 1999;289(2):641-8.
1999: RP Lee; Poh-Gek Forkert
Inactivation of cytochrome P-450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes by vinyl carbamate in murine pulmonary microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(2):233-9.
1999: Poh-Gek Forkert; Alvin M Malkinson; P Rice; M Moussa
Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(1):68-73.
1999: Poh-Gek Forkert; D D'Costa; Majid El-Mestrah
Expression and inducibility of alpha, pi, and Mu glutathione S-transferase protein and mRNA in murine lung.
American journal of respiratory cell and molecular biology 1999;20(1):143-52.
1998: Poh-Gek Forkert
Immunohistochemical detection of CYP2E1 and 2-S-glutathionyl acetate in murine lung tumors: diminished formation of reactive intermediates of 1,1-dichloroethylene.
Experimental lung research 1998;24(4):455-61.
1998: RP Lee; A Parkinson; Poh-Gek Forkert
Isozyme-selective metabolism of ethyl carbamate by cytochrome P450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes in murine liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(1):60-5.
1997: Poh-Gek Forkert; RP Lee
Metabolism of ethyl carbamate by pulmonary cytochrome P450 and carboxylesterase isozymes: involvement of CYP2E1 and hydrolase A.
Toxicology and applied pharmacology 1997;146(2):245-54.
1997: Poh-Gek Forkert; Kathy S Collins; T F Dowsley; Gregory M Ross
Immunochemical assay for recognition of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene-epoxide.
The Journal of pharmacology and experimental therapeutics 1997;281(3):1422-30.
1997: Poh-Gek Forkert
Conjugation of glutathione with the reactive metabolites of 1, 1-dichloroethylene in murine lung and liver.
Microscopy research and technique 1997;36(4):234-42.
1997: Poh-Gek Forkert
Coexpression of Ah receptor and CYP1A1 in hepatocytes of C57BL/6J and DBA/2J mice.
Toxicology and applied pharmacology 1997;142(1):69-78.
1996: Poh-Gek Forkert; T F Dowsley; RP Lee; J Y Hong; J B Ulreich
Differential formation of 1,1-dichloroethylene-metabolites in the lungs of adult and weanling male and female mice: correlation with severities of bronchiolar cytotoxicity.
The Journal of pharmacology and experimental therapeutics 1996;279(3):1484-90.
1996: T F Dowsley; J B Ulreich; Judy L Bolton; S S Park; Poh-Gek Forkert
CYP2E1-dependent bioactivation of 1,1-dichloroethylene in murine lung: formation of reactive intermediates and glutathione conjugates.
Toxicology and applied pharmacology 1996;139(1):42-8.
1996: Poh-Gek Forkert; RP Lee; T F Dowsley; J Y Hong; J B Ulreich
Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1665-71.
1996: Poh-Gek Forkert; A C Jackson; A Parkinson; S Chen
Diminished expression of CYP1A1 in urethane-induced lung tumors in strain A/J mice: analysis by in situ hybridization and immunohistochemical methods.
American journal of respiratory cell and molecular biology 1996;14(5):444-53.
1996: Poh-Gek Forkert; J A Lord; A Parkinson
Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice.
Carcinogenesis 1996;17(1):127-32.
1995: O O Oladapo; Poh-Gek Forkert
Detection and localization of CYP1A1/CYP1A2 in murine liver: electrophoresis, immunoblotting and immunocytochemistry.
African journal of medicine and medical sciences 1995;24(4):395-402.
1995: O O Oladapo; Poh-Gek Forkert
Changes in endoplasmic reticulum associated with beta-naphthoflavone-inducible cytochrome P450 in murine liver: a quantitative analysis.
African journal of medicine and medical sciences 1995;24(4):389-94.
1995: Poh-Gek Forkert
CYP2E1 is preferentially expressed in Clara cells of murine lung: localization by in situ hybridization and immunohistochemical methods.
American journal of respiratory cell and molecular biology 1995;12(6):589-96.
1995: T F Dowsley; Poh-Gek Forkert; L A Benesch; Judy L Bolton
Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene.
Chemico-biological interactions 1995;95(3):227-44.
1995: RP Lee; Poh-Gek Forkert
Pulmonary CYP2E1 bioactivates 1,1-dichloroethylene in male and female mice.
The Journal of pharmacology and experimental therapeutics 1995;273(1):561-7.
1995: Poh-Gek Forkert; S Chen; Alan C Jackson
In situ hybridization analysis of hepatic cytochrome P450 2E1 messenger ribonucleic acid in mice. Modulation of expression by acetone.
Laboratory investigation; a journal of technical methods and pathology 1995;72(1):92-9.
1994: Peter H Jellinck; A M Newcombe; Poh-Gek Forkert; C P Martucci
Distinct forms of hepatic androgen 6 beta-hydroxylase induced in the rat by indole-3-carbinol and pregnenolone carbonitrile.
The Journal of steroid biochemistry and molecular biology 1994;51(3-4):219-25.
1994: RP Lee; Poh-Gek Forkert
In vitro biotransformation of 1,1-dichloroethylene by hepatic cytochrome P-450 2E1 in mice.
The Journal of pharmacology and experimental therapeutics 1994;270(1):371-6.
1994: Poh-Gek Forkert; L Forkert
Trichloroethylene induces pulmonary fibrosis in mice.
Canadian journal of physiology and pharmacology 1994;72(3):205-10.
1994: Poh-Gek Forkert; Z M Redza; Steeve Mangos; S S Park; Shui-Pang Tam
Induction and regulation of CYP2E1 in murine liver after acute and chronic acetone administration.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(2):248-53.
1993: Poh-Gek Forkert; M Moussa
Temporal effects of 1,1-dichloroethylene on nonprotein sulfhydryl content in murine lung and liver.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(5):770-6.
1993: Peter H Jellinck; Poh-Gek Forkert; D S Riddick; Allan B Okey; J J Michnovicz; H Leon Bradlow
Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation.
Biochemical pharmacology 1993;45(5):1129-36.
1992: Poh-Gek Forkert; A Parkinson; Larry G Thaete; A M Malkinson
Resistance of murine lung tumors to xenobiotic-induced cytotoxicity.
Cancer research 1992;52(24):6797-803.
1992: M Moussa; Poh-Gek Forkert
1,1-Dichloroethylene-induced alterations in glutathione and covalent binding in murine lung: morphological, histochemical, and biochemical studies.
The Journal of pathology 1992;166(2):199-207.
1991: Poh-Gek Forkert; Thomas E Massey; A B Jones; S S Park; H V Gelboin; L M Anderson
Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration.
Carcinogenesis 1991;12(12):2259-68.
1990: Poh-Gek Forkert; H A Barton; M G Costantini; Michael A Marletta
The 4S polycyclic aromatic hydrocarbon-binding protein: immunohistochemical localization in mice.
Carcinogenesis 1990;11(10):1831-5.
1990: Poh-Gek Forkert; B A Geddes; D W Birch; Thomas E Massey
Morphologic changes and covalent binding of 1,1-dichloroethylene in Clara and alveolar type II cells isolated from lungs of mice following in vivo administration.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(4):534-9.
1989: Poh-Gek Forkert; M L Vessey; S S Park; H V Gelboin; SUSAN COLE
Cytochromes P-450 in murine lung. An immunohistochemical study with monoclonal antibodies.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(5):551-5.
1989: Poh-Gek Forkert; D W Birch
Pulmonary toxicity of trichloroethylene in mice. Covalent binding and morphological manifestations.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(1):106-13.
1988: Poh-Gek Forkert; P Mirehouse-Brown; S S Park; H V Gelboin
Distribution and induction sites of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in murine liver: immunohistochemical localization with monoclonal antibodies.
Molecular pharmacology 1988;34(6):736-43.
1987: Thomas E Massey; B A Geddes; Poh-Gek Forkert
Isolation of nonciliated bronchiolar epithelial (Clara) cells and alveolar type II cells from mouse lungs.
Canadian journal of physiology and pharmacology 1987;65(12):2368-72.
1987: Poh-Gek Forkert; M Hofley; William J Racz
Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes.
Canadian journal of physiology and pharmacology 1987;65(7):1496-9.
1987: Poh-Gek Forkert; K M Troughton
Airway injury by trichloroethylene: a scanning electron microscopic study.
The Journal of pathology 1987;152(2):119-25.
1986: Poh-Gek Forkert; V Stringer; William J Racz
Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice.
Experimental and molecular pathology 1986;45(1):44-58.
1986: Poh-Gek Forkert; M L Vessey; J S Elce; S S Park; H V Gelboin; SUSAN COLE
Localization of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in mouse lung with monoclonal antibodies.
Research communications in chemical pathology and pharmacology 1986;53(2):147-57.
1986: Poh-Gek Forkert; V Stringer; K M Troughton
Pulmonary toxicity of 1,1-dichloroethylene: correlation of early changes with covalent binding.
Canadian journal of physiology and pharmacology 1986;64(2):112-21.
1985: Poh-Gek Forkert; L Forkert; M Farooqui; E S Reynolds
Lung injury and repair: DNA synthesis following 1,1-dichloroethylene.
Toxicology 1985;36(2-3):199-214.
1982: Poh-Gek Forkert; E M Custer; A J Alpert; G A Ansari; E S Reynolds
Lactate dehydrogenase activity in mouse lung following 1,1-dichloroethylene: index of airway injury.
Experimental lung research 1982;4(1):67-77.
1982: Poh-Gek Forkert; E S Reynolds
1,1-Dichloroethylene-induced pulmonary injury.
Experimental lung research 1982;3(1):57-68.