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Tim Formosa

Research Profile

Chemicals & Drugs

Living Beings

Saccharomyces cerevisiae

Physiology

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Publications

TOP 3
David J Kemble; Laura L McCullough; Howard Robinson; Frank G Whitby; Tim Formosa; Christopher P Hill
Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT.
Beth M Stadtmueller; Debra M Eckert; K Ferrell; Tim Formosa; Erik Kish-Trier; David G Myszka; Charisse N Petersen; Howard Robinson; Christopher P Hill
Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function.
Laura McCullough; Aileen Olsen; Robert Rawlins; David J Stillman; Hua Xin; Tim Formosa
Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.

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All Publications

2013: David J Kemble; Laura L McCullough; Howard Robinson; Frank G Whitby; Tim Formosa; Christopher P Hill
Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT.
The Journal of biological chemistry 2013;288(15):10188-94.
2012: Beth M Stadtmueller; Debra M Eckert; K Ferrell; Tim Formosa; Erik Kish-Trier; David G Myszka; Charisse N Petersen; Howard Robinson; Christopher P Hill
Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function.
The Journal of biological chemistry 2012;287(44):37371-82.
2011: Laura McCullough; Aileen Olsen; Robert Rawlins; David J Stillman; Hua Xin; Tim Formosa
Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.
Genetics 2011;188(4):835-46.
2011: Devin Close; Sean J Johnson; Matthew A Sdano; Seth M McDonald; Howard Robinson; Tim Formosa; Christopher P Hill
Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain.
Journal of molecular biology 2011;408(4):697-713.
2011: Tim Formosa
A kinase's work is never done: Rad53 monitors chromatin near replication origins.
Cell cycle (Georgetown, Tex.) 2011;10(4):573-4.
2010: Seth M McDonald; Devin Close; Hua Xin; Tim Formosa; Christopher P Hill
Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding.
Molecular cell 2010;40(5):725-35.
2010: Tim Formosa
Avoiding a fatal attraction: properties of nucleosomes and a histone chaperone revealed under physiological conditions.
Molecular cell 2010;37(6):747-8.
2010: Kianoush Sadre-Bazzaz; Frank G Whitby; Howard Robinson; Tim Formosa; Christopher P Hill
Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.
Molecular cell 2010;37(5):728-35.
2009: Hua Xin; Shinya Takahata; Mary Blanksma; Laura McCullough; David J Stillman; Tim Formosa
yFACT induces global accessibility of nucleosomal DNA without H2A-H2B displacement.
Molecular cell 2009;35(3):365-76.
2008: Tim Formosa
FACT and the reorganized nucleosome.
Molecular bioSystems 2008;4(11):1085-93.
2008: Andrew P VanDemark; Hua Xin; Laura McCullough; Robert Rawlins; Shayla Bentley; Annie Heroux; David J Stillman; Christopher P Hill; Tim Formosa
Structural and functional analysis of the Spt16p N-terminal domain reveals overlapping roles of yFACT subunits.
The Journal of biological chemistry 2008;283(8):5058-68.
2008: Debabrata Biswas; Shinya Takahata; Hua Xin; Rinku Dutta-Biswas; Yaxin Yu; Tim Formosa; David J Stillman
A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae.
Genetics 2008;178(2):649-59.
2006: Shannon McCullock; Todd Kinard; Laura McCullough; Tim Formosa
blm3-1 is an allele of UBP3, a ubiquitin protease that appears to act during transcription of damaged DNA.
Journal of molecular biology 2006;363(3):660-72.
2006: Jack Iwanczyk; Kianoush Sadre-Bazzaz; Katherine Ferrell; Elena Kondrashkina; Tim Formosa; Christopher P Hill; Joaquin Ortega
Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes.
Journal of molecular biology 2006;363(3):648-59.
2006: Debabrata Biswas; Rinku Dutta-Biswas; Doyel Mitra; Yoichiro Shibata; Brian D Strahl; Tim Formosa; David J Stillman
Opposing roles for Set2 and yFACT in regulating TBP binding at promoters.
The EMBO journal 2006;25(19):4479-89.
2006: Andrew P VanDemark; Mary Blanksma; Elliott Ferris; Annie Heroux; Christopher P Hill; Tim Formosa
The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition.
Molecular cell 2006;22(3):363-74.
2005: Debabrata Biswas; Yaxin Yu; Matthew Prall; Tim Formosa; David J Stillman
The yeast FACT complex has a role in transcriptional initiation.
Molecular and cellular biology 2005;25(14):5812-22.
2004: Alison R Rhoades; Susan Ruone; Tim Formosa
Structural features of nucleosomes reorganized by yeast FACT and its HMG box component, Nhp6.
Molecular and cellular biology 2004;24(9):3907-17.
2003: Susan Ruone; Alison R Rhoades; Tim Formosa
Multiple Nhp6 molecules are required to recruit Spt16-Pob3 to form yFACT complexes and to reorganize nucleosomes.
The Journal of biological chemistry 2003;278(46):45288-95.
2003: Tim Formosa
Changing the DNA landscape: putting a SPN on chromatin.
Current topics in microbiology and immunology 2003;274():171-201.
2002: Tim Formosa; Susan Ruone; Melissa D Adams; Aileen E Olsen; Peter Eriksson; Yaxin Yu; Alison R Rhoades; Paul D Kaufman; David J Stillman
Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.
Genetics 2002;162(4):1557-71.
2001: Tim Formosa; Peter Eriksson; Jacqueline Wittmeyer; J Ginn; Yaxin Yu; David J Stillman
Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN.
The EMBO journal 2001;20(13):3506-17.
2000: M B Schlesinger; Tim Formosa
POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae.
Genetics 2000;155(4):1593-606.
1999: Jacqueline Wittmeyer; Lisa Joss; Tim Formosa
Spt16 and Pob3 of Saccharomyces cerevisiae form an essential, abundant heterodimer that is nuclear, chromatin-associated, and copurifies with DNA polymerase alpha.
Biochemistry 1999;38(28):8961-71.
1999: Tim Formosa; T Nittis
Dna2 mutants reveal interactions with Dna polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full Dna2 helicase activity is not essential for growth.
Genetics 1999;151(4):1459-70.
1998: Tim Formosa; T Nittis
Suppressors of the temperature sensitivity of DNA polymerase alpha mutations in Saccharomyces cerevisiae.
Molecular & general genetics : MGG 1998;257(4):461-8.
1997: Jacqueline Wittmeyer; Tim Formosa
The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein.
Molecular and cellular biology 1997;17(7):4178-90.
1996: J D Singer; B M Manning; Tim Formosa
Coordinating DNA replication to produce one copy of the genome requires genes that act in ubiquitin metabolism.
Molecular and cellular biology 1996;16(4):1356-66.
1995: Jacqueline Wittmeyer; Tim Formosa
Identifying DNA replication complex components using protein affinity chromatography.
Methods in enzymology 1995;262():415-30.
1992: J Miles; Tim Formosa
Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo.
Molecular and cellular biology 1992;12(12):5724-35.
1992: J Miles; Tim Formosa
Protein affinity chromatography with purified yeast DNA polymerase alpha detects proteins that bind to DNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1276-80.