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Albert Fornace

Research Profile

Disorders

DNA Damage

Living Beings

Mouse

Chemicals & Drugs

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Genes, p53

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TOP 3
Kamal Datta; Bhaskar V S Kallakury; Shubhankar Suman; Albert J Fornace
Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater β-Catenin Activation than γ Radiation in APC(Min/+) Mice.
Daniela Trani; Kamal Datta; Dan P Hartmann; Bhaskar Kallakury; Bo-Hyun Moon; Albert J Fornace
Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N/+ mice by exposure to γ rays.
Shubhankar Suman; Albert J Fornace; Michael D Johnson; Kamal Datta
Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland.

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2013: Kamal Datta; Bhaskar V S Kallakury; Shubhankar Suman; Albert J Fornace
Heavy Ion Radiation Exposure Triggered Higher Intestinal Tumor Frequency and Greater β-Catenin Activation than γ Radiation in APC(Min/+) Mice.
PloS one 2013;8(3):e59295.
2013: Daniela Trani; Kamal Datta; Dan P Hartmann; Bhaskar Kallakury; Bo-Hyun Moon; Albert J Fornace
Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N/+ mice by exposure to γ rays.
International journal of radiation oncology, biology, physics 2013;85(1):223-9.
2012: Shubhankar Suman; Albert J Fornace; Michael D Johnson; Kamal Datta
Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland.
International journal of radiation oncology, biology, physics 2012;84(2):500-7.
2012: Shubhankar Suman; Daniela Trani; Kamal Datta; Evagelia C Laiakis; Steven J Strawn; Albert J Fornace
Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice.
Radiation and environmental biophysics 2012;51(3):303-9.
2012: Ji-Seon Lee; Min Cheol Lee; Mi-Ok Lee; Bo-Hyun Moon; Sung Han Shim; Seung-Hyun Song; Albert J Fornace; Hyung Seok Kim; Seung U Kim; Jeong Taik Kwon; Hong Jun Lee; Hyukjin Cha
Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation.
Stem cell reviews 2012;8(2):532-45.
2012: Kamal Datta; Kathryn Doiron; Michael F Cole; Bhaskar V S Kallakury; Richard Kolesnick; Jimmy A Rotolo; Shubhankar Suman; Daniela Trani; Albert J Fornace
Accelerated hematopoietic toxicity by high energy (56)Fe radiation.
International journal of radiation biology 2012;88(3):213-22.
2012: Evagelia C Laiakis; Daniel R Hyduke; Albert J Fornace
Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors γ radiation and lipopolysaccharide.
Radiation research 2012;177(2):187-99.
2012: Kamal Datta; Daniel R Hyduke; Michael D Johnson; Bo-Hyun Moon; Shubhankar Suman; Albert J Fornace
Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland.
Radiation oncology (London, England) 2012;7():205.
2012: Kamal Datta; Bhaskar V S Kallakury; Shubhankar Suman; Albert J Fornace
Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine.
PloS one 2012;7(8):e42224.
2012: Shubhankar Suman; David R Taft; Chen Ren; Kamal Datta; Kathryn Doiron; Albert J Fornace; Ramesh Kumar; Manoj Maniar
Radioprotective effects of ON 01210.Na upon oral administration.
Journal of radiation research 2012;53(3):368-76.
2012: Shubhankar Suman; Albert J Fornace; Manoj Maniar; Kamal Datta
Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response.
Radiation oncology (London, England) 2012;7():6.
2011: Soumen K Manna; Andrew D Patterson; Qian Yang; Albert J Fornace; Jeffrey R Idle; Kristopher W Krausz; Frank J Gonzalez
UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model.
Journal of proteome research 2011;10(9):4120-33.
2011: Mi-Ok Lee; Hyeon-Jae Lee; Mi-Ae Kim; Eun-Kyung Kim; Ji-Hyun Lee; Jin-Hyung Heo; Seung-Hyuk Lee; Sang-Ho Cho; Albert J Fornace; Hye-Cheol Jeong; Hyukjin Cha
p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(3):423-31.
2010: V S Romanov; M V Abramova; Svetlana B Svetlikova; T V Bykova; S G Zubova; Nikolai D Aksenov; Albert J Fornace; Tatiana V Pospelova; Valery A Pospelov
p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate.
Cell cycle (Georgetown, Tex.) 2010;9(19):3945-55.
2010: Young Cha; Bo-hyun Moon; Mi-Ok Lee; Hee-jin Ahn; Hye-jin Lee; Kyung-ah Lee; Albert J Fornace; Kwang-soo Kim; Hyukjin Cha; Kyung-soon Park
Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling.
Stem cells (Dayton, Ohio) 2010;28(9):1476-86.
2010: Soumen K Manna; Andrew D Patterson; Qian Yang; Kristopher W Krausz; Henghong Li; Jeffrey R Idle; Albert J Fornace; Frank J Gonzalez
Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse.
Journal of proteome research 2010;9(8):4176-88.
2010: Jin-Ju Kim; Ji-Seon Lee; Bo-Hyun Moon; Mi-Ok Lee; Seun-Hyun Song; Henghong Li; Albert J Fornace; Hyukjin Cha
Wip1-expressing feeder cells retain pluripotency of co-cultured mouse embryonic stem cells under leukemia inhibitory factor-deprivated condition.
Archives of pharmacal research 2010;33(8):1253-60.
2010: Daniela Trani; Kamal Datta; Kathryn Doiron; Bhaskar V S Kallakury; Albert J Fornace
Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates.
Radiation and environmental biophysics 2010;49(3):389-96.
2010: Hyukjin Cha; Julie M Lowe; Henghong Li; Ji-Seon Lee; Galina I Belova; Dmitry V Bulavin; Albert J Fornace
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
Cancer research 2010;70(10):4112-22.
2010: Julie M Lowe; Hyukjin Cha; Qian Yang; Albert J Fornace
Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase.
The Journal of biological chemistry 2010;285(8):5249-57.
2010: Evagelia C Laiakis; Gerard A J Morris; Albert J Fornace; Stephen R C Howie
Metabolomic analysis in severe childhood pneumonia in the Gambia, West Africa: findings from a pilot study.
PloS one 2010;5(9):.
2009: Ji-Seon Lee; Mi-Ok Lee; Bo-Hyun Moon; Sung Han Shim; Albert J Fornace; Hyukjin Cha
Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways.
Stem cells (Dayton, Ohio) 2009;27(8):1963-75.
2009: Heidrun Ellinger-Ziegelbauer; Jennifer M Fostel; Chinami Aruga; Daniel Bauer; Eric Boitier; Shibing Deng; Donna Dickinson; Anne-Celine Le Fevre; Albert J Fornace; OLIVIER GRENET; Yizhong Gu; Jean-Christophe Hoflack; Masako Shiiyama; Roger Smith; Ronald D Snyder; Catherine Spire; Gotaro Tanaka; Jiri Aubrecht
Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(2):341-52.
2009: John B Tyburski; Andrew D Patterson; Kristopher W Krausz; Josef Slavík; Albert J Fornace; Frank J Gonzalez; Jeffrey R Idle
Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice.
Radiation research 2009;172(1):42-57.
2008: John B Tyburski; Andrew D Patterson; Kristopher W Krausz; Josef Slavík; Albert J Fornace; Frank J Gonzalez; Jeffrey R Idle
Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice.
Radiation research 2008;170(1):1-14.
2008: Xiangdong Lu; Chunyu Yang; Reginald Hill; Chaoying Yin; M Christine Hollander; Albert J Fornace; Terry Van Dyke
Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival.
Cancer research 2008;68(10):3579-83.
2008: Andrew D Patterson; Henghong Li; Gabriel S Eichler; Kristopher W Krausz; John N Weinstein; Albert J Fornace; Frank J Gonzalez; Jeffrey R Idle
UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation.
Analytical chemistry 2008;80(3):665-74.
2008: Sally A Amundson; Khanh T Do; Lisa C Vinikoor; R Anthony Lee; Christine A Koch-Paiz; Jaeyong Ahn; Mark Reimers; Yidong Chen; Dominic A Scudiero; John N Weinstein; Jeffrey M. Trent; Michael Bittner; Paul S Meltzer; Albert J Fornace
Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen.
Cancer research 2008;68(2):415-24.
2007: Heng-Hong Li; Jiri Aubrecht; Albert J Fornace
Toxicogenomics: overview and potential applications for the study of non-covalent DNA interacting chemicals.
Mutation research 2007;623(1-2):98-108.
2007: Warren W Ku; Jiri Aubrecht; Robert J Mauthe; Robert H Schiestl; Albert J Fornace
Genetic toxicity assessment: employing the best science for human safety evaluation Part VII: Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment.
Toxicological sciences : an official journal of the Society of Toxicology 2007;99(1):20-5.
2007: Hyukjin Cha; Xuetao Wang; Henghong Li; Albert J Fornace
A functional role for p38 MAPK in modulating mitotic transit in the absence of stress.
The Journal of biological chemistry 2007;282(31):22984-92.
2007: Oleg N Demidov; Calvina Kek; sathyavageeswaran shreeram; Oleg Timofeev; Albert J Fornace; Ettore Appella; Dmitry V Bulavin
The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.
Oncogene 2007;26(17):2502-6.
2007: Ludmila Jirmanova; Dragana Jankovic; Albert J Fornace; Jonathan D Ashwell
Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4153-8.
2006: sathyavageeswaran shreeram; Weng Kee Hee; Oleg N Demidov; Calvina Kek; Hiroshi Yamaguchi; Albert J Fornace; Carl W Anderson; Ettore Appella; Dmitry V Bulavin
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
The Journal of experimental medicine 2006;203(13):2793-9.
2006: sathyavageeswaran shreeram; Oleg N Demidov; Weng Kee Hee; Hiroshi Yamaguchi; Nobuyuki Onishi; Calvina Kek; Oleg Timofeev; Crissy Dudgeon; Albert J Fornace; Carl W Anderson; Yasuhiro Minami; Ettore Appella; Dmitry V Bulavin
Wip1 phosphatase modulates ATM-dependent signaling pathways.
Molecular cell 2006;23(5):757-64.
2006: Qi Cai; Natalia I Dmitrieva; Joan D Ferraris; Luis Michea; Jesus M Salvador; M Christine Hollander; Albert J Fornace; Robert A Fenton; MAURICE BURG
Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells.
American journal of physiology. Renal physiology 2006;291(2):F341-9.
2006: Maria V Abramova; Tatiana V Pospelova; Fedor P Nikulenkov; Christine M Hollander; Albert J Fornace; Valery A Pospelov
G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.
The Journal of biological chemistry 2006;281(30):21040-51.
2006: Crissy Dudgeon; Calvina Kek; Oleg N Demidov; Shin-ichi Saito; Kenneth Fernandes; Alexandra Diot; Jean-Christophe Bourdon; David P Lane; Ettore Appella; Albert J Fornace; Dmitry V Bulavin
Tumor susceptibility and apoptosis defect in a mouse strain expressing a human p53 transgene.
Cancer research 2006;66(6):2928-36.
2006: Andrew D Patterson; M Christine Hollander; Georgina F Miller; Albert J Fornace
Gadd34 requirement for normal hemoglobin synthesis.
Molecular and cellular biology 2006;26(5):1644-53.
2006: Andrew D Patterson; Jeffrey Hildesheim; Albert J Fornace; M Christine Hollander
Neural tube development requires the cooperation of p53- and Gadd45a-associated pathways.
Birth defects research. Part A, Clinical and molecular teratology 2006;76(2):129-32.
2006: Alexander bishop; Bela Kosaras; M C Hollander; Albert J Fornace; Richard L Sidman; Robert H Schiestl
p21 controls patterning but not homologous recombination in RPE development.
DNA repair 2006;5(1):111-20.
2005: Mamta Gupta; Shiv K Gupta; Arthur G Balliet; Mary Christine Hollander; Albert J Fornace; Barbara Hoffman; Dan A Liebermann
Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis.
Oncogene 2005;24(48):7170-9.
2005: Galina I Belova; Oleg N Demidov; Albert J Fornace; Dmitry V Bulavin
Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis.
Cancer biology & therapy 2005;4(10):1154-8.
2005: Ludmila Jirmanova; Dmitry V Bulavin; Albert J Fornace
Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells.
Cell cycle (Georgetown, Tex.) 2005;4(10):1428-34.
2005: M Christine Hollander; Robyn T Philburn; Andrew D Patterson; Susana Velasco-Miguel; Errol C Friedberg; R Ilona Linnoila; Albert J Fornace
Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13200-5.
2005: Paul R Mittelstadt; Jesus M Salvador; Albert J Fornace; Jonathan D Ashwell
Activating p38 MAPK: new tricks for an old kinase.
Cell cycle (Georgetown, Tex.) 2005;4(9):1189-92.
2005: Sally A Amundson; Khanh T Do; Lisa Vinikoor; Christine A Koch-Paiz; Michael Bittner; Jeffrey M. Trent; Paul Meltzer; Albert J Fornace
Stress-specific signatures: expression profiling of p53 wild-type and -null human cells.
Oncogene 2005;24(28):4572-9.
2005: Annette Khaled; Dmitry V Bulavin; Christina Kittipatarin; Wen Qing Li; Michelle Alvarez; Kyungjae Kim; Howard A Young; Albert J Fornace; Scott K Durum
Cytokine-driven cell cycling is mediated through Cdc25A.
The Journal of cell biology 2005;169(5):755-63.
2005: M Christine Hollander; R T Philburn; Andrew D Patterson; M A Wyatt; Albert J Fornace
Genomic instability in Gadd45a-/- cells is coupled with S-phase checkpoint defects.
Cell cycle (Georgetown, Tex.) 2005;4(5):704-9.
2005: M Christine Hollander; Andrew D Patterson; Jesus M Salvador; Miriam R Anver; Stephen P Hunger; Albert J Fornace
Gadd45a acts as a modifier locus for lymphoblastic lymphoma.
Leukemia 2005;19(5):847-50.
2005: Jeffrey Hildesheim; Jesus M Salvador; M Christine Hollander; Albert J Fornace
Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK.
The Journal of biological chemistry 2005;280(17):17221-6.
2005: Ranadip Pal; Aniruddha Datta; Albert J Fornace; Michael Bittner; Edward R Dougherty
Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS.
Bioinformatics (Oxford, England) 2005;21(8):1542-9.
2005: Jesus M Salvador; Paul R Mittelstadt; Galina I Belova; Albert J Fornace; Jonathan D Ashwell
The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.
Nature immunology 2005;6(4):396-402.
2005: Jesus M Salvador; Paul R Mittelstadt; Tad Guszczynski; Terry D Copeland; Hiroshi Yamaguchi; Ettore Appella; Albert J Fornace; Jonathan D Ashwell
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
Nature immunology 2005;6(4):390-5.
2005: Jason M Roper; Sean C Gehen; Rhonda J Staversky; M Christine Hollander; Albert J Fornace; Michael A O'Reilly
Loss of Gadd45a does not modify the pulmonary response to oxidative stress.
American journal of physiology. Lung cellular and molecular physiology 2005;288(4):L663-71.
2005: Nicholas C Denko; Albert J Fornace
Editorial comment: mutation research special issue on stress responses.
Mutation research 2005;569(1-2):1-2.
2004: Sally A Amundson; Marcy B Grace; Christopher B McLeland; Michael W Epperly; Andrew Yeager; Qimin Zhan; Joel S Greenberger; Albert J Fornace
Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients.
Cancer research 2004;64(18):6368-71.
2004: Xiaoyan Wang; Rui-Hong Wang; Wenmei Li; Xiaoling Xu; M Christine Hollander; Albert J Fornace; Chu-Xia Deng
Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure.
The Journal of biological chemistry 2004;279(28):29606-14.
2004: Jeffrey Hildesheim; Albert J Fornace
The dark side of light: the damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis.
DNA repair 2004;3(6):567-80.
2004: Christine A Koch-Paiz; Sally A Amundson; Michael Bittner; Paul S Meltzer; Albert J Fornace
Functional genomics of UV radiation responses in human cells.
Mutation research 2004;549(1-2):65-78.
2004: Dmitry V Bulavin; Crissy Phillips; Bonnie Nannenga; Oleg Timofeev; Lawrence A Donehower; Carl W Anderson; Ettore Appella; Albert J Fornace
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.
Nature genetics 2004;36(4):343-50.
2004: Jeffrey Hildesheim; Galina I Belova; Stuart D Tyner; Xiwu Zhou; Lilit Vardanian; Albert J Fornace
Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation.
Oncogene 2004;23(10):1829-37.
2004: Jeffrey Hildesheim; Rania T Awwad; Albert J Fornace
p38 Mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses.
The Journal of investigative dermatology 2004;122(2):497-502.
2004: John C Rockett; Michael Burczynski; Albert J Fornace; Paul C Herrmann; Stephen A Krawetz; David J Dix
Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells.
Toxicology and applied pharmacology 2004;194(2):189-99.
2004: Dmitry V Bulavin; Albert J Fornace
p38 MAP kinase's emerging role as a tumor suppressor.
Advances in cancer research 2004;92():95-118.
2004: Sally A Amundson; Albert J Fornace
Microarray approaches for analysis of cell cycle regulatory genes.
Methods in molecular biology (Clifton, N.J.) 2004;241():125-41.
2003: Feng Jiang; Pengfei Li; Albert J Fornace; Santo V Nicosia; Wenlong Bai
G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer.
The Journal of biological chemistry 2003;278(48):48030-40.
2003: Jiyun Yoo; Mayshan Ghiassi; Ludmila Jirmanova; Arthur G Balliet; Barbara Hoffman; Albert J Fornace; Dan A Liebermann; Erwin P Bottinger; Anita B Roberts
Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation.
The Journal of biological chemistry 2003;278(44):43001-7.
2003: Shin'ichi Saito; Hiroshi Yamaguchi; Yuichiro Higashimoto; Connie Chao; Yang Xu; Albert J Fornace; Ettore Appella; Carl W Anderson
Phosphorylation site interdependence of human p53 post-translational modifications in response to stress.
The Journal of biological chemistry 2003;278(39):37536-44.
2003: Alexander bishop; M Christine Hollander; Bela Kosaras; Richard L Sidman; Albert J Fornace; Robert H Schiestl
Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development.
Cancer research 2003;63(17):5335-43.
2003: Anastasia Goloudina; Hiroshi Yamaguchi; Daria B Chervyakova; Ettore Appella; Albert J Fornace; Dmitry V Bulavin
Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.
Cell cycle (Georgetown, Tex.) 2003;2(5):473-8.
2003: Sally A Amundson; Michael Bittner; Albert J Fornace
Functional genomics as a window on radiation stress signaling.
Oncogene 2003;22(37):5828-33.
2003: Arshad Amanullah; Naiyer Azam; Arthur G Balliet; Christine Hollander; Barbara Hoffman; Albert J Fornace; Dan A Liebermann
Cell signalling: cell survival and a Gadd45-factor deficiency.
Nature 2003;424(6950):741; discussion 742.
2003: Arthur G Balliet; M Christine Hollander; Albert J Fornace; Barbara Hoffman; Dan A Liebermann
Comparative analysis of the genetic structure and chromosomal mapping of the murine Gadd45g/CR6 gene.
DNA and cell biology 2003;22(7):457-68.
2003: Sally A Amundson; Albert J Fornace
Monitoring human radiation exposure by gene expression profiling: possibilities and pitfalls.
Health physics 2003;85(1):36-42.
2003: M Christine Hollander; Silpa Poola-Kella; Albert J Fornace
Gadd34 functional domains involved in growth suppression and apoptosis.
Oncogene 2003;22(25):3827-32.
2003: Dmitry V Bulavin; Yuichiro Higashimoto; Zoya N Demidenko; Sarah E M Meek; Paul Graves; Crissy Phillips; Hui Zhao; Sally A Moody; Ettore Appella; Helen Piwnica-Worms; Albert J Fornace
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry.
Nature cell biology 2003;5(6):545-51.
2003: Dmitry V Bulavin; Oleg Kovalsky; M Christine Hollander; Albert J Fornace
Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a.
Molecular and cellular biology 2003;23(11):3859-71.
2003: Dmitry V Bulavin; Zoya N Demidenko; Crissy Phillips; Sally A Moody; Albert J Fornace
Phosphorylation of Xenopus Cdc25C at Ser285 interferes with ability to activate a DNA damage replication checkpoint in pre-midblastula embryos.
Cell cycle (Georgetown, Tex.) 2003;2(3):263-6.
2003: Sally A Amundson; Richard Anthony Lee; Christine A Koch-Paiz; Michael Bittner; Paul Meltzer; Jeffrey M. Trent; Albert J Fornace
Differential responses of stress genes to low dose-rate gamma irradiation.
Molecular cancer research : MCR 2003;1(6):445-52.
2003: Sally A Amundson; Albert J Fornace
Microarray approaches for analysis of tumor suppressor gene function.
Methods in molecular biology (Clifton, N.J.) 2003;223():141-54.
2002: Jeffrey Hildesheim; Dmitry V Bulavin; Miriam R Anver; W Gregory Alvord; M Christine Hollander; Lilit Vardanian; Albert J Fornace
Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53.
Cancer research 2002;62(24):7305-15.
2002: Feiyue Fan; Shunqian Jin; Sally A Amundson; Tong Tong; Wenhong Fan; Hongcheng Zhao; Xiaocheng Zhu; Lucia Mazzacurati; Xianxing Li; Kimberly L Petrik; Albert J Fornace; Baskaran Rajasekaran; Qimin Zhan
ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth.
Oncogene 2002;21(49):7488-96.
2002: Akio Morinobu; Massimo Gadina; Warren Strober; Roberta Visconti; Albert J Fornace; Cristina Montagna; Gerald M Feldman; Ryuta Nishikomori; John O'Shea
STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12281-6.
2002: M Christine Hollander; Albert J Fornace
Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a.
Oncogene 2002;21(40):6228-33.
2002: Jeffrey Hildesheim; Albert J Fornace
Gadd45a: an elusive yet attractive candidate gene in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2475-9.
2002: Dmitry V Bulavin; Oleg N Demidov; Shin'ichi Saito; Päivikki Kauraniemi; Crissy Phillips; Sally A Amundson; Concetta Ambrosino; Guido Sauter; Angel R Nebreda; Carl W Anderson; Anne Kallioniemi; Albert J Fornace; Ettore Appella
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.
Nature genetics 2002;31(2):210-5.
2002: Hien Tran; Anne Brunet; Jill M Grenier; Sandeep Robert Datta; Albert J Fornace; Peter S DiStefano; Lillian W Chiang; Michael E Greenberg
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein.
Science (New York, N.Y.) 2002;296(5567):530-4.
2002: Jesus M Salvador; M Christine Hollander; Anh Thu Nguyen; Jeffrey B Kopp; Laura Barisoni; Jodene K Moore; Jonathan D Ashwell; Albert J Fornace
Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.
Immunity 2002;16(4):499-508.
2002: Sally A Amundson; A Patterson; Khanh T Do; Albert J Fornace
A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes.
Cancer biology & therapy 2002;1(2):145-9.
2002: Albert J Fornace; Sally A Amundson; Khanh T Do; Paul Meltzer; Jeffrey M. Trent; Michael Bittner
Stress-gene induction by low-dose gamma irradiation.
Military medicine 2002;167(2 Suppl):13-5.
2002: Dmitry V Bulavin; Sally A Amundson; Albert J Fornace
p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony.
Current opinion in genetics & development 2002;12(1):92-7.
2002: Natalia I Dmitrieva; Dmitry V Bulavin; Albert J Fornace; MAURICE BURG
Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):184-9.
2002: Martin L Smith; Albert J Fornace
Chemotherapeutic targeting of p53.
Cancer biology & therapy 2002;1(1):56-7.
2001: Sally A Amundson; Michael Bittner; Paul Meltzer; Jeffrey M. Trent; Albert J Fornace
Induction of gene expression as a monitor of exposure to ionizing radiation.
Radiation research 2001;156(5 Pt 2):657-61.
2001: Oleg Kovalsky; Feng-Di T Lung; Peter P Roller; Albert J Fornace
Oligomerization of human Gadd45a protein.
The Journal of biological chemistry 2001;276(42):39330-9.
2001: Sally A Amundson; Michael Bittner; Paul Meltzer; Jeffrey M. Trent; Albert J Fornace
Biological indicators for the identification of ionizing radiation exposure in humans.
Expert review of molecular diagnostics 2001;1(2):211-9.
2001: Sally A Amundson; Michael Bittner; Paul Meltzer; Jeffrey M. Trent; Albert J Fornace
Physiological function as regulation of large transcriptional programs: the cellular response to genotoxic stress.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2001;129(4):703-10.
2001: Dmitry V Bulavin; Yuichiro Higashimoto; Ian J Popoff; William A Gaarde; venkatesha basrur; Olga Potapova; Ettore Appella; Albert J Fornace
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.
Nature 2001;411(6833):102-7.
2001: M Christine Hollander; Oleg Kovalsky; Jesus M Salvador; K E Kim; Andrew D Patterson; D C Haines; Albert J Fornace
Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency.
Cancer research 2001;61(6):2487-91.
2001: M C Hollander; MS Sheikh; K Yu; Qimin Zhan; M Iglesias; Craig D Woodworth; Albert J Fornace
Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors.
International journal of cancer. Journal international du cancer 2001;96(1):22-31.
2000: Sally A Amundson; Timothy G Myers; Dominic A Scudiero; Shinichi Kitada; J C Reed; Albert J Fornace
An informatics approach identifying markers of chemosensitivity in human cancer cell lines.
Cancer research 2000;60(21):6101-10.
2000: Sally A Amundson; Khanh T Do; S Shahab; Michael Bittner; Paul Meltzer; Jeffrey M. Trent; Albert J Fornace
Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation.
Radiation research 2000;154(3):342-6.
2000: Shunqian Jin; Hongcheng Zhao; Feiyue Fan; P Blanck; Wenhong Fan; A B Colchagie; Albert J Fornace; Qimin Zhan
BRCA1 activation of the GADD45 promoter.
Oncogene 2000;19(35):4050-7.
2000: Hongcheng Zhao; Shunqian Jin; Michael J Antinore; Feng-Di T Lung; Feiyue Fan; P Blanck; Peter P Roller; Albert J Fornace; Qimin Zhan
The central region of Gadd45 is required for its interaction with p21/WAF1.
Experimental cell research 2000;258(1):92-100.
2000: Shunqian Jin; Michael J Antinore; Feng-Di T Lung; X Dong; Hongcheng Zhao; Feiyue Fan; A B Colchagie; P Blanck; Peter P Roller; Albert J Fornace; Qimin Zhan
The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression.
The Journal of biological chemistry 2000;275(22):16602-8.
2000: Guillermo Elizondo; Pedro Fernandez-Salguero; M S Sheikh; G Y Kim; Albert J Fornace; Kyung S Lee; Frank J Gonzalez
Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast.
Molecular pharmacology 2000;57(5):1056-63.
2000: ML Smith; J M Ford; M Christine Hollander; RA Bortnick; Sally A Amundson; Y R Seo; Chu-Xia Deng; P C Hanawalt; Albert J Fornace
p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes.
Molecular and cellular biology 2000;20(10):3705-14.
1999: Dmitry V Bulavin; S Saito; M Christine Hollander; K Sakaguchi; Carl W Anderson; Ettore Appella; Albert J Fornace
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.
The EMBO journal 1999;18(23):6845-54.
1999: MS Sheikh; Albert J Fornace
Regulation of translation initiation following stress.
Oncogene 1999;18(45):6121-8.
1999: M Christine Hollander; MS Sheikh; Dmitry V Bulavin; K Lundgren; L Augeri-Henmueller; R Shehee; T A Molinaro; K E Kim; E Tolosa; Jonathan D Ashwell; Michael P Rosenberg; Qimin Zhan; P M Fernández-Salguero; William F Morgan; Chu-Xia Deng; Albert J Fornace
Genomic instability in Gadd45a-deficient mice.
Nature genetics 1999;23(2):176-84.
1999: Sally A Amundson; Khanh T Do; Albert J Fornace
Induction of stress genes by low doses of gamma rays.
Radiation research 1999;152(3):225-31.
1999: MS Sheikh; Yanping Huang; E A Fernandez-Salas; Wafik S El-Deiry; H Friess; Sally A Amundson; Jing Yin; Meltzer Stephen J.; Nikki J Holbrook; Albert J Fornace
The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract.
Oncogene 1999;18(28):4153-9.
1999: F Goldwasser; I Bae; Yves Pommier; Albert J Fornace
Evidence of a reduced DNA topoisomerase II mRNA expression after ionizing radiation.
Anticancer research 1999;19(4B):3167-71.
1999: Sally A Amundson; Michael Bittner; Yidong Chen; Jeffrey M. Trent; Paul Meltzer; Albert J Fornace
Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses.
Oncogene 1999;18(24):3666-72.
1999: Yanping Huang; MS Sheikh; Albert J Fornace; Nikki J Holbrook
Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells.
Oncogene 1999;18(23):3431-9.
1999: MS Sheikh; E Fernandez-Salas; M Yu; Arif Hussain; Jonathan D. Dinman; Stuart Peltz; Yanping Huang; Albert J Fornace
Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)).
The Journal of biological chemistry 1999;274(23):16487-93.
1999: Qimin Zhan; Michael J Antinore; Xin Wei Wang; France Carrier; ML Smith; Curtis C Harris; Albert J Fornace
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45.
Oncogene 1999;18(18):2892-900.
1999: Xin Wei Wang; Qimin Zhan; JD Coursen; M A Khan; H Udo Kontny; Linda Yu; M Christine Hollander; Patrick M O'Connor; Albert J Fornace; Curtis C Harris
GADD45 induction of a G2/M cell cycle checkpoint.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3706-11.
1999: France Carrier; Philippe Georgel; Philippe Pourquier; Mellissa Blake; H Udo Kontny; Michael J Antinore; M Gariboldi; Timothy G Myers; John N Weinstein; Yves Pommier; Albert J Fornace
Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin.
Molecular and cellular biology 1999;19(3):1673-85.
1999: Qimin Zhan; Udo Kontny; M Iglesias; I Alamo; K Yu; M Christine Hollander; Craig D Woodworth; Albert J Fornace
Inhibitory effect of Bcl-2 on p53-mediated transactivation following genotoxic stress.
Oncogene 1999;18(2):297-304.
1999: Albert J Fornace; Sally A Amundson; Michael Bittner; Timothy G Myers; Paul Meltzer; J N Weinsten; Jeffrey M. Trent
The complexity of radiation stress responses: analysis by informatics and functional genomics approaches.
Gene expression 1999;7(4-6):387-400.
1998: Sally A Amundson; Timothy G Myers; Albert J Fornace
Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress.
Oncogene 1998;17(25):3287-99.
1998: MS Sheikh; Michael J Antinore; Yanping Huang; Albert J Fornace
Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1.
Oncogene 1998;17(20):2555-63.
1998: Sally A Amundson; Qimin Zhan; L Z Penn; Albert J Fornace
Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents.
Oncogene 1998;17(17):2149-54.
1998: H Zaher; Pedro Fernandez-Salguero; John J Letterio; M S Sheikh; Albert J Fornace; Anita B Roberts; Frank J Gonzalez
The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis.
Molecular pharmacology 1998;54(2):313-21.
1998: ML Smith; RA Bortnick; M S Sheikh; Albert J Fornace
Chromatin relaxation by overexpression of mutant p53, HPV16-E6, or cyclin G transgenes.
Experimental cell research 1998;242(1):235-43.
1998: Qimin Zhan; I T Chen; Michael J Antinore; Albert J Fornace
Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding.
Molecular and cellular biology 1998;18(5):2768-78.
1998: MS Sheikh; Timothy F Burns; Yanping Huang; Gen Sheng Wu; Sally A Amundson; K S Brooks; Albert J Fornace; Wafik S El-Deiry
p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.
Cancer research 1998;58(8):1593-8.
1998: France Carrier; Qimin Zhan; I Alamo; F Hanaoka; Albert J Fornace
Evidence for distinct kinase-mediated pathways in gadd gene responses.
Biochemical pharmacology 1998;55(6):853-61.
1998: Lei Zhang; Qimin Zhan; S Zhan; F Kashanchi; Albert J Fornace; Pankaj Seth; Lee Helman
p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells.
DNA and cell biology 1998;17(2):125-31.
1997: Martin L Smith; Albert J Fornace
p53-mediated protective responses to UV irradiation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12255-7.
1997: MS Sheikh; France Carrier; M A Papathanasiou; M Christine Hollander; Qimin Zhan; K Yu; Albert J Fornace
Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein.
The Journal of biological chemistry 1997;272(42):26720-6.
1997: Patrick M O'Connor; J Jackman; I Bae; Timothy G Myers; S Fan; Michihiro Mutoh; Dominic A Scudiero; Anne Monks; Edward A Sausville; John N Weinstein; SH Friend; Albert J Fornace; Kurt W Kohn
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
Cancer research 1997;57(19):4285-300.
1997: MS Sheikh; France Carrier; A C Johnson; S E Ogdon; Albert J Fornace
Identification of an additional p53-responsive site in the human epidermal growth factor receptor gene promotor.
Oncogene 1997;15(9):1095-101.
1997: M Christine Hollander; Qimin Zhan; I Bae; Albert J Fornace
Mammalian GADD34, an apoptosis- and DNA damage-inducible gene.
The Journal of biological chemistry 1997;272(21):13731-7.
1997: S Fan; J K Chang; ML Smith; D Duba; Albert J Fornace; Patrick M O'Connor
Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard.
Oncogene 1997;14(18):2127-36.
1997: MS Sheikh; Yong Q Chen; ML Smith; Albert J Fornace
Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells.
Oncogene 1997;14(15):1875-82.
1997: Qimin Zhan; Christine K Bieszczad; I Bae; Albert J Fornace; Ruth W Craig
Induction of BCL2 family member MCL1 as an early response to DNA damage.
Oncogene 1997;14(9):1031-9.
1997: J N Weinstein; Timothy G Myers; P M O'Connor; S H Friend; Albert J Fornace; K W Kohn; T Fojo; S E Bates; L V Rubinstein; N L Anderson; JK Buolamwini; W W van Osdol; Anne Monks; Dominic A Scudiero; Edward A Sausville; Daniel W Zaharevitz; B Bunow; Vellarkad Viswanadhan; G S Johnson; R E Wittes; KD Paull
An information-intensive approach to the molecular pharmacology of cancer.
Science (New York, N.Y.) 1997;275(5298):343-9.
1997: ML Smith; H Udo Kontny; RA Bortnick; Albert J Fornace
The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity.
Experimental cell research 1997;230(1):61-8.
1996: MS Sheikh; Marcel Garcia; Qimin Zhan; Y Liu; Albert J Fornace
Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(12):1599-607.
1996: Qimin Zhan; I Alamo; K Yu; Lawrence Boise; Barry Cherney; Giovanna Tosato; Patrick M O'Connor; Albert J Fornace
The apoptosis-associated gamma-ray response of BCL-X(L) depends on normal p53 function.
Oncogene 1996;13(10):2287-93.
1996: ML Smith; H Udo Kontny; Qimin Zhan; A Sreenath; Patrick M O'Connor; Albert J Fornace
Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin.
Oncogene 1996;13(10):2255-63.
1996: Qimin Zhan; S Fan; ML Smith; I Bae; K Yu; I Alamo; Patrick M O'Connor; Albert J Fornace
Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation.
DNA and cell biology 1996;15(10):805-15.
1996: France Carrier; I Bae; ML Smith; D M Ayers; Albert J Fornace
Characterization of the GADD45 response to ionizing radiation in WI-L2-NS cells, a p53 mutant cell line.
Mutation research 1996;352(1-2):79-86.
1996: ML Smith; Albert J Fornace
Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis.
Mutation research 1996;340(2-3):109-24.
1996: M Christine Hollander; I Alamo; Albert J Fornace
A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein product.
Nucleic acids research 1996;24(9):1589-93.
1996: L Zhang; Fatah Kashanchi; Qimin Zhan; S Zhan; John N Brady; Albert J Fornace; Pankaj Seth; Lee Helman
Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.
Cancer research 1996;56(6):1367-73.
1996: I Bae; ML Smith; MS Sheikh; Qimin Zhan; Dominic A Scudiero; S H Friend; Patrick M O'Connor; Albert J Fornace
An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines.
Cancer research 1996;56(4):840-7.
1996: I T Chen; M Akamatsu; ML Smith; Feng-Di T Lung; D Duba; Peter P Roller; Albert J Fornace; Patrick M O'Connor
Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction.
Oncogene 1996;12(3):595-607.
1996: F Goldwasser; I Bae; Albert J Fornace; Yves Pommier
Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines.
Oncology research 1996;8(7-8):317-23.
1995: J Gu; Ronald Dubner; Albert J Fornace; Michael Iadarola
UREB1, a tyrosine phosphorylated nuclear protein, inhibits p53 transactivation.
Oncogene 1995;11(10):2175-8.
1995: I T Chen; ML Smith; Patrick M O'Connor; Albert J Fornace
Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA.
Oncogene 1995;11(10):1931-7.
1995: I Bae; S Fan; Kishor Bhatia; Kurt W Kohn; Albert J Fornace; Patrick M O'Connor
Relationships between G1 arrest and stability of the p53 and p21Cip1/Waf1 proteins following gamma-irradiation of human lymphoma cells.
Cancer research 1995;55(11):2387-93.
1995: S Fan; ML Smith; Dennis Rivet; D Duba; Qimin Zhan; Kurt W Kohn; Albert J Fornace; Patrick M O'Connor
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
Cancer research 1995;55(8):1649-54.
1995: I Bae; ML Smith; Albert J Fornace
Induction of p53-, MDM2-, and WAF1/CIP1-like molecules in insect cells by DNA-damaging agents.
Experimental cell research 1995;217(2):541-5.
1995: ML Smith; I T Chen; Qimin Zhan; Patrick M O'Connor; Albert J Fornace
Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.
Oncogene 1995;10(6):1053-9.
1994: ML Smith; Qimin Zhan; I Bae; Albert J Fornace
Role of retinoblastoma gene product in p53-mediated DNA damage response.
Experimental cell research 1994;215(2):386-9.
1994: Qimin Zhan; S Fan; I Bae; Christel Guillouf; Dan A Liebermann; Patrick M O'Connor; Albert J Fornace
Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.
Oncogene 1994;9(12):3743-51.
1994: H Zhang; D A Cooney; A Sreenath; Qimin Zhan; Riad Agbaria; E E Stowe; Albert J Fornace; David G Johns
Quantitation of mitochondrial DNA in human lymphoblasts by a competitive polymerase chain reaction method: application to the study of inhibitors of mitochondrial DNA content.
Molecular pharmacology 1994;46(6):1063-9.
1994: ML Smith; I T Chen; Qimin Zhan; I Bae; C Y Chen; Tona M Gilmer; Michael B Kastan; Patrick M O'Connor; Albert J Fornace
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
Science (New York, N.Y.) 1994;266(5189):1376-80.
1994: S Fan; Wafik S El-Deiry; I Bae; J Freeman; D Jondle; Kishor Bhatia; Albert J Fornace; Ian Magrath; Kurt W Kohn; Patrick M O'Connor
p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.
Cancer research 1994;54(22):5824-30.
1994: J Jackman; I Alamo; Albert J Fornace
Genotoxic stress confers preferential and coordinate messenger RNA stability on the five gadd genes.
Cancer research 1994;54(21):5656-62.
1994: Shilpy Sharma; Antonio C Wolff; C Y Chen; Albert J Fornace; Michael B Kastan
The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.
Cancer research 1994;54(19):5054-8.
1994: France Carrier; J M McCary; I Bae; Daniel B Yarosh; Albert J Fornace
Activation of HIV type 1 long terminal repeat by ultraviolet light is serum and strain specific.
AIDS research and human retroviruses 1994;10(7):767-73.
1994: Qimin Zhan; I Bae; Michael B Kastan; Albert J Fornace
The p53-dependent gamma-ray response of GADD45.
Cancer research 1994;54(10):2755-60.
1994: Qimin Zhan; K A Lord; I Alamo; M Christine Hollander; France Carrier; D Ron; K W Kohn; Barbara Hoffman; Dan A Liebermann; Albert J Fornace
The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.
Molecular and cellular biology 1994;14(4):2361-71.
1994: France Carrier; A Gatignol; M Christine Hollander; K T Jeang; Albert J Fornace
Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1554-8.
1993: M Christine Hollander; I Alamo; J Jackman; M G Wang; O W McBride; Albert J Fornace
Analysis of the mammalian gadd45 gene and its response to DNA damage.
The Journal of biological chemistry 1993;268(32):24385-93.
1993: Qimin Zhan; France Carrier; Albert J Fornace
Induction of cellular p53 activity by DNA-damaging agents and growth arrest.
Molecular and cellular biology 1993;13(7):4242-50.
1993: Daniel B Yarosh; L Alas; Jeannie Kibitel; Adrienne O'Connor; France Carrier; Albert J Fornace
Cyclobutane pyrimidine dimers in UV-DNA induce release of soluble mediators that activate the human immunodeficiency virus promoter.
The Journal of investigative dermatology 1993;100(6):790-4.
1992: Albert J Fornace; J Jackman; M Christine Hollander; B Hoffman-Liebermann; Dan A Liebermann
Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest.
Annals of the New York Academy of Sciences 1992;663():139-53.
1992: Michael B Kastan; Qimin Zhan; Wafik S El-Deiry; France Carrier; Tyler Jacks; W V Walsh; B S Plunkett; Bert Vogelstein; Albert J Fornace
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
Cell 1992;71(4):587-97.
1992: J S Park; J D Luethy; M G Wang; J Fargnoli; Albert J Fornace; O W McBride; Nikki J Holbrook
Isolation, characterization and chromosomal localization of the human GADD153 gene.
Gene 1992;116(2):259-67.
1991: P S Kedar; S G Widen; E W Englander; Albert J Fornace; Samuel H Wilson
The ATF/CREB transcription factor-binding site in the polymerase beta promoter mediates the positive effect of N-methyl-N'-nitro-N-nitrosoguanidine on transcription.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3729-33.
1991: M A Papathanasiou; N C Kerr; J H Robbins; O W McBride; I Alamo; S F Barrett; I D Hickson; Albert J Fornace
Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.
Molecular and cellular biology 1991;11(2):1009-16.
1990: Albert J Fornace; M A Papathanasiou; M Christine Hollander; Daniel B Yarosh
Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells.
Cancer research 1990;50(24):7908-11.
1990: J D Luethy; J Fargnoli; J S Park; Albert J Fornace; Nikki J Holbrook
Isolation and characterization of the hamster gadd153 gene. Activation of promoter activity by agents that damage DNA.
The Journal of biological chemistry 1990;265(27):16521-6.
1990: Albert J Fornace; P P Dobson; T J Kinsella
Enhancement of radiation damage in cellular DNA following unifilar substitution with iododeoxyuridine.
International journal of radiation oncology, biology, physics 1990;18(4):873-8.
1990: J Fargnoli; T Kunisada; Albert J Fornace; E L Schneider; Nikki J Holbrook
Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):846-50.
1989: Albert J Fornace; Daniel W Nebert; M Christine Hollander; J D Luethy; M Papathanasiou; J Fargnoli; Nikki J Holbrook
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.
Molecular and cellular biology 1989;9(10):4196-203.
1989: Albert J Fornace; I Alamo; M Christine Hollander; E Lamoreaux
Induction of heat shock protein transcripts and B2 transcripts by various stresses in Chinese hamster cells.
Experimental cell research 1989;182(1):61-74.
1989: M Christine Hollander; Albert J Fornace
Induction of fos RNA by DNA-damaging agents.
Cancer research 1989;49(7):1687-92.
1989: Albert J Fornace; I Alamo; M Christine Hollander; E Lamoreaux
Ubiquitin mRNA is a major stress-induced transcript in mammalian cells.
Nucleic acids research 1989;17(3):1215-30.
1989: Albert J Fornace; B Zmudzka; M Christine Hollander; Samuel H Wilson
Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells.
Molecular and cellular biology 1989;9(2):851-3.
1988: Albert J Fornace; I Alamo; M Christine Hollander
DNA damage-inducible transcripts in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):8800-4.
1988: Albert J Fornace; H Schalch; I Alamo
Coordinate induction of metallothioneins I and II in rodent cells by UV irradiation.
Molecular and cellular biology 1988;8(11):4716-20.
1988: B Z Zmudzka; Albert J Fornace; J Collins; Samuel H Wilson
Characterization of DNA polymerase beta mRNA: cell-cycle and growth response in cultured human cells.
Nucleic acids research 1988;16(20):9587-96.
1987: T J Kinsella; P P Dobson; Albert J Fornace; S F Barrett; M B Ganges; J H Robbins
Alzheimer's disease fibroblasts have normal repair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage determined by the alkaline elution technique.
Biochemical and biophysical research communications 1987;149(2):355-61.