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Stephen Fortunato

Research Profile

Physiology

Pregnancy

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TOP 3
Ramkumar Menon; Stephen J Fortunato; Digna R Velez Edwards; Scott M Williams
Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations.
Kelli K Ryckman; Nils-Halvdan Morken; Marquitta J White; Digna R Velez; Ramkumar Menon; Stephen J Fortunato; Per Magnus; Scott M Williams; Bo Jacobsson
Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
Digna R Velez; Stephen J Fortunato; Poul Thorsen; Salvatore J Lombardi; scott williams; Menon Ramkumar
Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.

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All Publications

2010: Ramkumar Menon; Stephen J Fortunato; Digna R Velez Edwards; Scott M Williams
Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations.
Annals of human genetics 2010;74(2):165-83.
2010: Kelli K Ryckman; Nils-Halvdan Morken; Marquitta J White; Digna R Velez; Ramkumar Menon; Stephen J Fortunato; Per Magnus; Scott M Williams; Bo Jacobsson
Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
PloS one 2010;5(2):e9040.
2009: Digna R Velez; Stephen J Fortunato; Poul Thorsen; Salvatore J Lombardi; scott williams; Menon Ramkumar
Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
American journal of obstetrics and gynecology 2009;200(2):209.e1-27.
2009: Menon Ramkumar; Brad Pearce; Digna R Velez; Mario Merialdi; scott williams; Stephen J Fortunato; Poul Thorsen
Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
Reproductive biology and endocrinology : RB&E 2009;7():62.
2008: Menon Ramkumar; Digna R Velez; Nicole Morgan; Salvatore J Lombardi; Stephen J Fortunato; scott williams
Genetic regulation of amniotic fluid TNF-alpha and soluble TNF receptor concentrations affected by race and preterm birth.
Human genetics 2008;124(3):243-53.
2008: Digna R Velez; Stephen J Fortunato; Nicole Morgan; Todd L Edwards; Salvatore J Lombardi; scott williams; Menon Ramkumar
Patterns of cytokine profiles differ with pregnancy outcome and ethnicity.
Human reproduction (Oxford, England) 2008;23(8):1902-9.
2008: Stephen J Fortunato; Menon Ramkumar; Digna R Velez; Poul Thorsen; scott williams
Racial disparity in maternal-fetal genetic epistasis in spontaneous preterm birth.
American journal of obstetrics and gynecology 2008;198(6):666.e1-9; discussion 666.e9-10.
2008: Digna R Velez; Stephen J Fortunato; scott williams; Menon Ramkumar
Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.
Human molecular genetics 2008;17(11):1619-30.
2008: Digna R Velez; Menon Ramkumar; Hyagriv N Simhan; Stephen J Fortunato; Jeffrey A Canter; scott williams
Mitochondrial DNA variant A4917G, smoking and spontaneous preterm birth.
Mitochondrion 2008;8(2):130-5.
2008: Digna R Velez; Stephen J Fortunato; Poul Thorsen; Salvatore J Lombardi; scott williams; Menon Ramkumar
Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
PloS one 2008;3(9):e3283.
2008: Menon Ramkumar; M Constanza Camargo; Poul Thorsen; Salvatore J Lombardi; Stephen J Fortunato
Amniotic fluid interleukin-6 increase is an indicator of spontaneous preterm birth in white but not black Americans.
American journal of obstetrics and gynecology 2008;198(1):77.e1-7.
2007: Digna R Velez; Menon Ramkumar; Poul Thorsen; Lan Jiang; Hyagriv N Simhan; N Morgan; Stephen J Fortunato; scott williams
Ethnic differences in interleukin 6 (IL-6) and IL6 receptor genes in spontaneous preterm birth and effects on amniotic fluid protein levels.
Annals of human genetics 2007;71(Pt 5):586-600.
2007: Menon Ramkumar; P Thorsen; Ida Vogel; Bo Jacobsson; scott williams; Stephen J Fortunato
Increased bioavailability of TNF-alpha in African Americans during in vitro infection: predisposing evidence for immune imbalance.
Placenta 2007;28(8-9):946-50.
2007: Menon Ramkumar; Stephen J Fortunato
Infection and the role of inflammation in preterm premature rupture of the membranes.
Best practice & research. Clinical obstetrics & gynaecology 2007;21(3):467-78.
2006: Menon Ramkumar; Stephen J Fortunato; Poul Thorsen; Scott Williams
Genetic associations in preterm birth: a primer of marker selection, study design, and data analysis.
Journal of the Society for Gynecologic Investigation 2006;13(8):531-41.
2006: Menon Ramkumar; Mario Merialdi; Ana Pilar BETRAN LAZAGA; Siobhan M Dolan; Lan Jiang; Stephen J Fortunato; Scott Williams
Analysis of association between maternal tumor necrosis factor-alpha promoter polymorphism (-308), tumor necrosis factor concentration, and preterm birth.
American journal of obstetrics and gynecology 2006;195(5):1240-8.
2006: Menon Ramkumar; Mario Merialdi; Salvatore J Lombardi; Stephen J Fortunato
Differences in the placental membrane cytokine response: a possible explanation for the racial disparity in preterm birth.
American journal of reproductive immunology (New York, N.Y. : 1989) 2006;56(2):112-8.
2006: Menon Ramkumar; Digna R Velez; Hyagriv N Simhan; Kelli Ryckman; Lan Jiang; Poul Thorsen; Ida Vogel; Bo Jacobsson; Mario Merialdi; scott williams; Stephen J Fortunato
Multilocus interactions at maternal tumor necrosis factor-alpha, tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American women.
American journal of obstetrics and gynecology 2006;194(6):1616-24.
2006: Menon Ramkumar; J Oliver McIntyre; Lynn M Matrisian; Stephen J Fortunato
Salivary proteinase activity: a potential biomarker for preterm premature rupture of the membranes.
American journal of obstetrics and gynecology 2006;194(6):1609-15; discussion 1615.
2006: Menon Ramkumar; Lana Ismail; Deema Ismail; Mario Merialdi; Salvatore J Lombardi; Stephen J Fortunato
Human fetal membrane expression of IL-19 and IL-20 and its differential effect on inflammatory cytokine production.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2006;19(4):209-14.
2006: Menon Ramkumar; Digna R Velez; Poul Thorsen; Ida Vogel; Bo Jacobsson; scott williams; Stephen J Fortunato
Ethnic differences in key candidate genes for spontaneous preterm birth: TNF-alpha and its receptors.
Human heredity 2006;62(2):107-18.
2004: Menon Ramkumar; Stephen J Fortunato
The role of matrix degrading enzymes and apoptosis in rupture of membranes.
Journal of the Society for Gynecologic Investigation 2004;11(7):427-37.
2004: Stephen J Fortunato; Salvatore J Lombardi; Menon Ramkumar
Racial disparity in membrane response to infectious stimuli: a possible explanation for observed differences in the incidence of prematurity. Community Award Paper.
American journal of obstetrics and gynecology 2004;190(6):1557-62; discussion 1562-3.
2004: Menon Ramkumar; Stephen J Fortunato
Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways.
Journal of perinatal medicine 2004;32(5):391-9.
2003: Stephen J Fortunato; Menon Ramkumar
IL-1 beta is a better inducer of apoptosis in human fetal membranes than IL-6.
Placenta 2003;24(10):922-8.
2003: Stephen J Fortunato; Bonnie J Lafleur; Menon Ramkumar
Collagenase-3 (MMP-13) in fetal membranes and amniotic fluid during pregnancy.
American journal of reproductive immunology (New York, N.Y. : 1989) 2003;49(2):120-5.
2002: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
Role of tumor necrosis factor-alpha in the premature rupture of membranes and preterm labor pathways.
American journal of obstetrics and gynecology 2002;187(5):1159-62.
2002: Stephen J Fortunato; Menon Ramkumar
Screening of novel matrix metalloproteinases (MMPs) in human fetal membranes.
Journal of assisted reproduction and genetics 2002;19(10):483-6.
2002: Menon Ramkumar; Salvatore J Lombardi; Stephen J Fortunato
TNF-alpha promotes caspase activation and apoptosis in human fetal membranes.
Journal of assisted reproduction and genetics 2002;19(4):201-4.
2001: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi; Bonnie J Lafleur
Interleukin-10 inhibition of gelatinases in fetal membranes: therapeutic implications in preterm premature rupture of membranes.
Obstetrics and gynecology 2001;98(2):284-8.
2001: Stephen J Fortunato; Menon Ramkumar
Distinct molecular events suggest different pathways for preterm labor and premature rupture of membranes.
American journal of obstetrics and gynecology 2001;184(7):1399-405; discussion 1405-6.
2001: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
Support for an infection-induced apoptotic pathway in human fetal membranes.
American journal of obstetrics and gynecology 2001;184(7):1392-7; discussion 1397-8.
2001: Menon Ramkumar; Salvatore J Lombardi; Stephen J Fortunato
IL-18, a product of choriodecidual cells, increases during premature rupture of membranes but fails to turn on the Fas-FasL-mediated apoptosis pathway.
Journal of assisted reproduction and genetics 2001;18(5):276-84.
2001: Menon Ramkumar; S Gerber; Stephen J Fortunato; S S Witkin
Lipopolysaccharide stimulation of 70 kilo Dalton heat shock protein messenger ribonucleic acid production in cultured human fetal membranes.
Journal of perinatal medicine 2001;29(2):133-6.
2000: Stephen J Fortunato; Menon Ramkumar; C Bryant; Salvatore J Lombardi
Programmed cell death (apoptosis) as a possible pathway to metalloproteinase activation and fetal membrane degradation in premature rupture of membranes.
American journal of obstetrics and gynecology 2000;182(6):1468-76.
2000: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
Amniochorion gelatinase-gelatinase inhibitor imbalance in vitro: a possible infectious pathway to rupture.
Obstetrics and gynecology 2000;95(2):240-4.
1999: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
Stromelysins in placental membranes and amniotic fluid with premature rupture of membranes.
Obstetrics and gynecology 1999;94(3):435-40.
1999: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
MMP/TIMP imbalance in amniotic fluid during PROM: an indirect support for endogenous pathway to membrane rupture.
Journal of perinatal medicine 1999;27(5):362-8.
1998: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
Presence of four tissue inhibitors of matrix metalloproteinases (TIMP-1, -2, -3 and -4) in human fetal membranes.
American journal of reproductive immunology (New York, N.Y. : 1989) 1998;40(6):395-400.
1998: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
The effect of transforming growth factor and interleukin-10 on interleukin-8 release by human amniochorion may regulate histologic chorioamnionitis.
American journal of obstetrics and gynecology 1998;179(3 Pt 1):794-9.
1998: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
Expression of a progelatinase activator (MT1-MMP) in human fetal membranes.
American journal of reproductive immunology (New York, N.Y. : 1989) 1998;39(5):316-22.
1998: Stephen J Fortunato; Salvatore J Lombardi; Menon Ramkumar
Immunoreactivity of human fetal membranes to peptidoglycan polysaccharide (PGPS): cytokine response.
Journal of perinatal medicine 1998;26(6):442-7.
1998: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
IL-15, a novel cytokine produced by human fetal membranes, is elevated in preterm labor.
American journal of reproductive immunology (New York, N.Y. : 1989) 1998;39(1):16-23.
1997: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
Interleukin-10 and transforming growth factor-beta inhibit amniochorion tumor necrosis factor-alpha production by contrasting mechanisms of action: therapeutic implications in prematurity.
American journal of obstetrics and gynecology 1997;177(4):803-9.
1997: Stephen J Fortunato; Menon Ramkumar; Salvatore J Lombardi
Collagenolytic enzymes (gelatinases) and their inhibitors in human amniochorionic membrane.
American journal of obstetrics and gynecology 1997;177(4):731-41.
1996: Stephen J Fortunato; Menon Ramkumar; Kenneth F Swan; Salvatore J Lombardi
Interleukin-10 inhibition of interleukin-6 in human amniochorionic membrane: transcriptional regulation.
American journal of obstetrics and gynecology 1996;175(4 Pt 1):1057-65.
1996: Stephen J Fortunato; R P Menon; Kenneth F Swan; Menon Ramkumar
Inflammatory cytokine (interleukins 1, 6 and 8 and tumor necrosis factor-alpha) release from cultured human fetal membranes in response to endotoxic lipopolysaccharide mirrors amniotic fluid concentrations.
American journal of obstetrics and gynecology 1996;174(6):1855-61; discussion 1861-2.
1996: Stephen J Fortunato
The use of power Doppler and color power angiography in fetal imaging.
American journal of obstetrics and gynecology 1996;174(6):1828-31; discussion 1831-3.
1995: Stephen J Fortunato; Menon Ramkumar; Kenneth F Swan
Amniochorion: a source of interleukin-8.
American journal of reproductive immunology (New York, N.Y. : 1989) 1995;34(3):156-62.
1995: Menon Ramkumar; Kenneth F Swan; T W Lyden; Neal Rote; Stephen J Fortunato
Expression of inflammatory cytokines (interleukin-1 beta and interleukin-6) in amniochorionic membranes.
American journal of obstetrics and gynecology 1995;172(2 Pt 1):493-500.
1994: Stephen J Fortunato; Menon Ramkumar; Kenneth F Swan
Expression of TNF-alpha and TNFR p55 in cultured amniochorion.
American journal of reproductive immunology (New York, N.Y. : 1989) 1994;32(3):188-93.
1994: Stephen J Fortunato; Menon Ramkumar; Kenneth F Swan; T W Lyden
Organ culture of amniochorionic membrane in vitro.
American journal of reproductive immunology (New York, N.Y. : 1989) 1994;32(3):184-7.
1994: Stephen J Fortunato; S I Welt; M K Eggleston; E C Bryant
Active expectant management in very early gestations complicated by premature rupture of the fetal membranes.
The Journal of reproductive medicine 1994;39(1):13-6.
1993: Stephen J Fortunato; S I Welt; J T Stewart
Differential protein binding of ceftizoxime in cord versus maternal serum.
American journal of obstetrics and gynecology 1993;168(3 Pt 1):914-5.
1992: Stephen J Fortunato; Roger E Bawdon; Kenneth F Swan; E C Bryant; S Sobhi
Transfer of Timentin (ticarcillin and clavulanic acid) across the in vitro perfused human placenta: comparison with other agents.
American journal of obstetrics and gynecology 1992;167(6):1595-9.
1991: Roger E Bawdon; M C Maberry; Stephen J Fortunato; Larry C Gilstrap; S Kim
Trimethoprim and sulfamethoxazole transfer in the in vitro perfused human cotyledon.
Gynecologic and obstetric investigation 1991;31(4):240-2.
1990: Stephen J Fortunato; S I Welt; M Eggleston; J Cole; E C Bryant; M G Dodson
Prolongation of the latency period in preterm premature rupture of the membranes using prophylactic antibiotics and tocolysis.
Journal of perinatology : official journal of the California Perinatal Association 1990;10(3):252-6.
1990: Stephen J Fortunato; Roger E Bawdon; M C Maberry; K F Swan
Transfer of ceftizoxime surpasses that of cefoperazone by the isolated human placenta perfused in vitro.
Obstetrics and gynecology 1990;75(5):830-3.
1990: L Milewich; Stephen J Fortunato; M Barris; M C Maberry; Larry C Gilstrap; PC MacDonald
17 beta-Hydroxysteroid oxidoreductase activity in human maternal and umbilical cord sera.
Journal of steroid biochemistry 1990;35(1):67-75.
1989: B S Minhas; R Kumar; D D Ricker; W E Roudebush; M G Dodson; Stephen J Fortunato
Effects of platelet activating factor on mouse oocyte fertilization in vitro.
American journal of obstetrics and gynecology 1989;161(6 Pt 1):1714-7.
1989: D L Stewart; S Wilkerson; Stephen J Fortunato
New technique for stabilizing umbilical artery catheters in very low birthweight infants.
Journal of perinatology : official journal of the California Perinatal Association 1989;9(4):458-9.
1989: Stephen J Fortunato; Roger E Bawdon
Determination of pentamidine transfer in the in vitro perfused human cotyledon with high-performance liquid chromatography.
American journal of obstetrics and gynecology 1989;160(3):759-61.
1988: Stephen J Fortunato; Roger E Bawdon; M Baum
Placental transfer of cefoperazone and sulbactam in the isolated in vitro perfused human placenta.
American journal of obstetrics and gynecology 1988;159(4):1002-6.
1988: Stephen J Fortunato; Roger E Bawdon; S I Welt; K F Swan
Steady-state cord and amniotic fluid ceftizoxime levels continuously surpass maternal levels.
American journal of obstetrics and gynecology 1988;159(3):570-3.
1988: Stephen J Fortunato; L J Mercer; David S Guzick
External cephalic version with tocolysis: factors associated with success.
Obstetrics and gynecology 1988;72(1):59-62.
1988: Kenneth J Leveno; Stephen J Fortunato; P Raskin; M L Williams; P J Whalley
Continuous subcutaneous insulin infusion during pregnancy.
Diabetes research and clinical practice 1988;4(4):257-68.
1988: C Richard Parker; Stephen J Fortunato; Bruce R Carr; J Owen; G D Hankins; J C Hauth
Apolipoprotein A-1 in umbilical cord blood of newborn infants: relation to gestational age and high-density lipoprotein cholesterol.
Pediatric research 1988;23(4):348-51.
1988: M G Dodson; Stephen J Fortunato
Microorganisms and premature labor.
The Journal of reproductive medicine 1988;33(1 Suppl):87-96.
1988: Stephen J Fortunato; M G Dodson
Therapeutic considerations in postpartum endometritis.
The Journal of reproductive medicine 1988;33(1 Suppl):101-6.