FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Amanda Fosang

Research Profile

Chemicals & Drugs

Anatomy

Co-author Network

Publications

TOP 3
Amanda J Fosang; Suzanne B Golub; Charlotte J East; Fraser M Rogerson
Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26RLacZ reporter mice.
André Struglics; Jonathan Akikusa; Roger Allen; Karena Last; L Stefan Lohmander; Amanda J Fosang
Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.
Edward R Bastow; Suzanne B Golub; Karena Last; Amanda C Stanley; Jennifer L Stow; Amanda J Fosang
Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Amanda Fosang (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Amanda J Fosang; Suzanne B Golub; Charlotte J East; Fraser M Rogerson
Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26RLacZ reporter mice.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2013;21(2):401-4.
2012: André Struglics; Jonathan Akikusa; Roger Allen; Karena Last; L Stefan Lohmander; Amanda J Fosang
Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.
Arthritis and rheumatism 2012;64(12):4151-61; author reply 4162-3.
2012: Edward R Bastow; Suzanne B Golub; Karena Last; Amanda C Stanley; Jennifer L Stow; Amanda J Fosang
Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.
Biology open 2012;1(4):318-28.
2011: Amanda J Fosang; Frank Beier
Emerging Frontiers in cartilage and chondrocyte biology.
Best practice & research. Clinical rheumatology 2011;25(6):751-66.
2011: Heather Stanton; Christopher B Little; James Melrose; Amanda J Fosang
Proteoglycan degradation by the ADAMTS family of proteinases.
Biochimica et biophysica acta 2011;1812(12):1616-29.
2011: Heather Stanton; Suzanne B Golub; Fraser M Rogerson; Karena Last; Christopher B Little; Amanda J Fosang
Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.
Nature protocols 2011;6(3):388-404.
2010: Wataru Ariyoshi; Cheryl B Knudson; Na Luo; Amanda J Fosang; Warren Knudson
Internalization of aggrecan G1 domain neoepitope ITEGE in chondrocytes requires CD44.
The Journal of biological chemistry 2010;285(46):36216-24.
2010: Fraser M Rogerson; Yuen M Chung; Michael E Deutscher; Karena Last; Amanda J Fosang
Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice.
Arthritis and rheumatism 2010;62(11):3365-73.
2010: Amanda J Fosang; F M Rogerson
Identifying the human aggrecanase.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(9):1109-16.
2010: Christopher B Little; Amanda J Fosang
Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis?
Current drug targets 2010;11(5):561-75.
2010: Amanda J Fosang; Karena Last; Heather Stanton; Suzanne B Golub; Christopher B Little; Lorena Brown; David C Jackson
Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan.
Methods in molecular biology (Clifton, N.J.) 2010;622():312-47.
2009: Peter Kannu; John F Bateman; Daniele Belluoccio; Amanda J Fosang; Ravi Savarirayan
Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis.
Arthritis and rheumatism 2009;60(2):325-34.
2009: Amanda J Fosang; Karena Last; C J Poon; A H Plaas
Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan.
Matrix biology : journal of the International Society for Matrix Biology 2009;28(1):53-61.
2008: S J Gauci; Suzanne B Golub; L Tutolo; Christopher B Little; Natalie Sims; E R Lee; E J Mackie; Amanda J Fosang
Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage.
Journal of musculoskeletal & neuronal interactions 2008;8(4):308-10.
2008: Richard Wilson; Daniele Belluoccio; Christopher B Little; Amanda J Fosang; John F Bateman
Proteomic characterization of mouse cartilage degradation in vitro.
Arthritis and rheumatism 2008;58(10):3120-31.
2008: Amanda J Fosang; Christopher B Little
Drug insight: aggrecanases as therapeutic targets for osteoarthritis.
Nature clinical practice. Rheumatology 2008;4(8):420-7.
2008: Fraser M Rogerson; Heather Stanton; Charlotte J East; Suzanne B Golub; Leonie Tutolo; Pamela J Farmer; Amanda J Fosang
Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5.
Arthritis and rheumatism 2008;58(6):1664-73.
2008: E R Bastow; S Byers; Suzanne B Golub; C E Clarkin; A A Pitsillides; Amanda J Fosang
Hyaluronan synthesis and degradation in cartilage and bone.
Cellular and molecular life sciences : CMLS 2008;65(3):395-413.
2008: Morten A Karsdal; Suzi H Madsen; Claus Christiansen; Kim Henriksen; Amanda J Fosang; Bodil C Sondergaard
Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity.
Arthritis research & therapy 2008;10(3):R63.
2008: Amanda J Fosang; Fraser M Rogerson; Charlotte J East; Heather Stanton
ADAMTS-5: the story so far.
European cells & materials 2008;15():11-26.
2007: Mirna Z Ilic; Charlotte J East; Fraser M Rogerson; Amanda J Fosang; Christopher J Handley
Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.
The Journal of biological chemistry 2007;282(52):37420-8.
2007: Jessica Faggian; Amanda J Fosang; Malgorzata Zieba; Megan J Wallace; Stuart B Hooper
Changes in versican and chondroitin sulfate proteoglycans during structural development of the lung.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(2):R784-92.
2007: Christopher B Little; Clare T Meeker; Suzanne B Golub; Kate E Lawlor; Pamela J Farmer; Susan M Smith; Amanda J Fosang
Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair.
The Journal of clinical investigation 2007;117(6):1627-36.
2007: Morten A Karsdal; Eren Ufuk Sumer; Helle Wulf; Suzi H Madsen; Claus Christiansen; Amanda J Fosang; Bodil-Cecilie Sondergaard
Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.
Arthritis and rheumatism 2007;56(5):1549-58.
2007: Charlotte J East; Heather Stanton; Suzanne B Golub; Fraser M Rogerson; Amanda J Fosang
ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.
The Journal of biological chemistry 2007;282(12):8632-40.
2007: Eren Ufuk Sumer; Bodil-Cecilie Sondergaard; J C Rousseau; P D Delmas; Amanda J Fosang; Morten A Karsdal; Claus Christiansen; Per Qvist
MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(2):212-21.
2006: M C Stewart; Amanda J Fosang; Yun Bai; Barbara Osborn; Anna Plaas; John D Sandy
ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(4):392-402.
2006: Jennifer J Embry Flory; Amanda J Fosang; Warren Knudson
The accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan.
Arthritis and rheumatism 2006;54(2):443-54.
2005: Sarah Knox; Amanda J Fosang; Karena Last; James Melrose; John Michael Whitelock
Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.
FEBS letters 2005;579(22):5019-23.
2005: Christopher J Poon; Anna Plaas; Douglas R Keene; David J McQuillan; Karena Last; Amanda J Fosang
N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.
The Journal of biological chemistry 2005;280(25):23615-21.
2005: Christopher B Little; Laureane Mittaz; Daniele Belluoccio; Fraser M Rogerson; Ian K Campbell; Clare T Meeker; John F Bateman; Melanie A Pritchard; Amanda J Fosang
ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo.
Arthritis and rheumatism 2005;52(5):1461-72.
2005: Yuan H Yang; Pam Hall; Christopher B Little; Amanda J Fosang; Georgia Milenkovski; Leilani Santos; Jin Xue; Peter G Tipping; Eric F Morand
Reduction of arthritis severity in protease-activated receptor-deficient mice.
Arthritis and rheumatism 2005;52(4):1325-32.
2005: Christopher B Little; Clare T Meeker; Rosalind M Hembry; Natalie Sims; Kate E Lawlor; Suzanne B Golub; Karena Last; Amanda J Fosang
Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.
Molecular and cellular biology 2005;25(8):3388-99.
2005: Heather Stanton; Fraser M Rogerson; Charlotte J East; Suzanne B Golub; Kate E Lawlor; Clare T Meeker; Christopher B Little; Karena Last; Pamela J Farmer; Ian K Campbell; Anne M Fourie; Amanda J Fosang
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
Nature 2005;434(7033):648-52.
2004: Dominique Stickens; Danielle J Behonick; Nathalie Ortega; Babette Heyer; Bettina Hartenstein; Ying Yu; Amanda J Fosang; Marina Schorpp-Kistner; Peter Angel; Zena Werb
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.
Development (Cambridge, England) 2004;131(23):5883-95.
2004: Rochelle Boland; Belinda J Joyce; Megan J Wallace; Heather Stanton; Amanda J Fosang; Richard A Pierce; Richard Harding; Stuart B Hooper
Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep.
The Journal of physiology 2004;554(Pt 2):505-17.
2003: Amanda J Fosang; Heather Stanton; Christopher B Little; L M Atley
Neoepitopes as biomarkers of cartilage catabolism.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52(7):277-82.
2002: Heather Stanton; Amanda J Fosang
Matrix metalloproteinases are active following guanidine hydrochloride extraction of cartilage: generation of DIPEN neoepitope during dialysis.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(5):425-8.
2002: Heather Stanton; Linh Ung; Amanda J Fosang
The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.
The Biochemical journal 2002;364(Pt 1):181-90.
2002: Jennifer Westling; Amanda J Fosang; Karena Last; Vivian P Thompson; Kathy N Tomkinson; Tracy Hebert; Thomas McDonagh; Lisa A Collins-Racie; Edward R LaVallie; Elisabeth A Morris; John D Sandy
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
The Journal of biological chemistry 2002;277(18):16059-66.
2001: Rosalind M Hembry; J Dyce; I M K Driesang; Ernst B Hunziker; Amanda J Fosang; J A Tyler; Gillian Murphy
Immunolocalization of matrix metalloproteinases in partial-thickness defects in pig articular cartilage. A preliminary report.
The Journal of bone and joint surgery. American volume 2001;83-A(6):826-38.
2001: Amanda J Fosang; Karena Last; D C Jackson; L Brown
Antibodies to MMP-cleaved aggrecan.
Methods in molecular biology (Clifton, N.J.) 2001;151():425-49.
2000: FA Mercuri; R A Maciewicz; J Tart; Karena Last; Amanda J Fosang
Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.
The Journal of biological chemistry 2000;275(42):33038-45.
2000: Amanda J Fosang; Karena Last; Heather Stanton; D B Weeks; Ian K Campbell; T E Hardingham; Rosalind M Hembry
Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.
The Journal of biological chemistry 2000;275(42):33027-37.
2000: Jan Stracke; Amanda J Fosang; Karena Last; FA Mercuri; Alberto Pendas; Elena Llano; R Perris; Paul Dicesare; Gillian Murphy; Vera Knäuper
Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).
FEBS letters 2000;478(1-2):52-6.
1999: FA Mercuri; K J Doege; Elizabeth C Arner; Michael A Pratta; Karena Last; Amanda J Fosang
Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase.
The Journal of biological chemistry 1999;274(45):32387-95.
1998: Amanda J Fosang; Karena Last; Y Fujii; Motoharu Seiki; Y Okada
Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain.
FEBS letters 1998;430(3):186-90.
1997: Vincenzo Russo; Leon A Bach; Amanda J Fosang; NL Baker; George Werther
Insulin-like growth factor binding protein-2 binds to cell surface proteoglycans in the rat brain olfactory bulb.
Endocrinology 1997;138(11):4858-67.
1996: Amanda J Fosang; Karena Last; R A Maciewicz
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
The Journal of clinical investigation 1996;98(10):2292-9.
1996: Amanda J Fosang; Karena Last; V Knäuper; G Murphy; peter neame
Degradation of cartilage aggrecan by collagenase-3 (MMP-13).
FEBS letters 1996;380(1-2):17-20.
1995: R N LePage; Amanda J Fosang; S J Fuller; G Murphy; Geneviève Evin; Konrad Beyreuther; Colin L Masters; David Small
Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease.
FEBS letters 1995;377(2):267-70.
1995: Amanda J Fosang; Karena Last; P Gardiner; D C Jackson; L Brown
Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.
The Biochemical journal 1995;310 ( Pt 1)():337-43.
1995: P Mahadevan; Richard G Larkins; J R Fraser; Amanda J Fosang; Marjorie Dunlop
Increased hyaluronan production in the glomeruli from diabetic rats: a link between glucose-induced prostaglandin production and reduced sulphated proteoglycan.
Diabetologia 1995;38(3):298-305.
1995: T E Hardingham; Amanda J Fosang
The structure of aggrecan and its turnover in cartilage.
The Journal of rheumatology. Supplement 1995;43():86-90.
1995: C E Hughes; B Caterson; Amanda J Fosang; P J Roughley; J S Mort
Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
The Biochemical journal 1995;305 ( Pt 3)():799-804.
1994: Amanda J Fosang; Karena Last; peter neame; G Murphy; V Knäuper; H Tschesche; C E Hughes; B Caterson; T E Hardingham
Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.
The Biochemical journal 1994;304 ( Pt 2)():347-51.
1994: T E Hardingham; Amanda J Fosang; Jayesh Dudhia
The structure, function and turnover of aggrecan, the large aggregating proteoglycan from cartilage.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1994;32(4):249-57.
1994: T E Hardingham; Amanda J Fosang; N J Hey; P K Hazell; W J Kee; R J Ewins
The sulphation pattern in chondroitin sulphate chains investigated by chondroitinase ABC and ACII digestion and reactivity with monoclonal antibodies.
Carbohydrate research 1994;255():241-54.
1993: Amanda J Fosang; Karena Last; V Knäuper; peter neame; G Murphy; T E Hardingham; H Tschesche; John A Hamilton
Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.
The Biochemical journal 1993;295 ( Pt 1)():273-6.
1992: Amanda J Fosang; peter neame; Karena Last; T E Hardingham; G Murphy; John A Hamilton
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
The Journal of biological chemistry 1992;267(27):19470-4.
1992: T E Hardingham; Amanda J Fosang
Proteoglycans: many forms and many functions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(3):861-70.
1991: Amanda J Fosang; peter neame; T E Hardingham; G Murphy; John A Hamilton
Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins.
The Journal of biological chemistry 1991;266(24):15579-82.
1991: Amanda J Fosang; J A Tyler; T E Hardingham
Effect of interleukin-1 and insulin like growth factor-1 on the release of proteoglycan components and hyaluronan from pig articular cartilage in explant culture.
Matrix (Stuttgart, Germany) 1991;11(1):17-24.
1991: Amanda J Fosang; T E Hardingham
1-C-6 epitope in cartilage proteoglycan G2 domain is masked by keratan sulphate.
The Biochemical journal 1991;273(Pt 2)():369-73.
1990: Amanda J Fosang; N J Hey; Stepheb Carney; T E Hardingham
An ELISA plate-based assay for hyaluronan using biotinylated proteoglycan G1 domain (HA-binding region).
Matrix (Stuttgart, Germany) 1990;10(5):306-13.
1990: Gillian Murphy; Rosalind M Hembry; C E Hughes; Amanda J Fosang; T E Hardingham
Role and regulation of metalloproteinases in connective tissue turnover.
Biochemical Society transactions 1990;18(5):812-5.
1990: T E Hardingham; Amanda J Fosang; Jayesh Dudhia
Domain structure in aggregating proteoglycans from cartilage.
Biochemical Society transactions 1990;18(5):794-6.
1990: Jayesh Dudhia; Amanda J Fosang; T E Hardingham
Domain structure and sequence similarities in cartilage proteoglycan.
Biochemical Society transactions 1990;18(2):198-200.
1989: Amanda J Fosang; T E Hardingham
Isolation of the N-terminal globular protein domains from cartilage proteoglycans. Identification of G2 domain and its lack of interaction with hyaluronate and link protein.
The Biochemical journal 1989;261(3):801-9.