Siegfried Ansorge

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Bernstein Hans-Gert; Ernst Theresia; Lendeckel Uwe; Bukowska Alicja; Ansorge Siegfried; Stauch Renate; Have Sara Ten; Steiner Johann; Dobrowolny Henrik; Bogerts Bernhard
Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia.
Reinhold Dirk; Goihl Alexander; Wrenger Sabine; Reinhold Annegret; Kühlmann Ulrike C; Faust Jürgen; Neubert Klaus; Thielitz Anja; Brocke Stefan; Täger Michael; Ansorge Siegfried; Bank Ute
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Ansorge Siegfried; Bank Ute; Heimburg Anke; Helmuth Martin; Koch Gudrun; Tadje Janine; Lendeckel Uwe; Wolke Carmen; Neubert Klaus; Faust Jürgen; Fuchs Petra; Reinhold Dirk; Thielitz Anja; Täger Michael
Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions.

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2009: Bernstein Hans-Gert; Ernst Theresia; Lendeckel Uwe; Bukowska Alicja; Ansorge Siegfried; Stauch Renate; Have Sara Ten; Steiner Johann; Dobrowolny Henrik; Bogerts Bernhard
Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia.
Journal of psychiatric research 2009;43(13):1095-105.
2009: Reinhold Dirk; Goihl Alexander; Wrenger Sabine; Reinhold Annegret; Kühlmann Ulrike C; Faust Jürgen; Neubert Klaus; Thielitz Anja; Brocke Stefan; Täger Michael; Ansorge Siegfried; Bank Ute
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009;47(3):268-74.
2009: Ansorge Siegfried; Bank Ute; Heimburg Anke; Helmuth Martin; Koch Gudrun; Tadje Janine; Lendeckel Uwe; Wolke Carmen; Neubert Klaus; Faust Jürgen; Fuchs Petra; Reinhold Dirk; Thielitz Anja; Täger Michael
Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009;47(3):253-61.
2008: Thielitz Anja; Vetter Robert W; Schultze Bianca; Wrenger Sabine; Simeoni Luca; Ansorge Siegfried; Neubert Klaus; Faust Jürgen; Lindenlaub Petra; Gollnick Harald P M; Reinhold Dirk
Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts.
The Journal of investigative dermatology 2008;128(4):855-66.
2008: Bernstein Hans-Gert; Lendeckel Uwe; Bukowska Alicja; Ansorge Siegfried; Ernst Theresia; Stauch Renate; Trübner Kurt; Steiner Johann; Dobrowolny Henrik; Bogerts Bernhard
Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary.
Journal of chemical neuroanatomy 2008;35(2):216-24.
2008: Thielitz Anja; Ansorge Siegfried; Bank Ute; Tager Michael; Wrenger Sabine; Gollnick Harald; Reinhold Dirk
The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseases.
Frontiers in bioscience : a journal and virtual library 2008;13():2364-75.
2008: Reinhold Dirk; Bank Ute; Täger Michael; Ansorge Siegfried; Wrenger Sabine; Thielitz Anja; Lendeckel Uwe; Faust Jürgen; Neubert Klaus; Brocke Stefan
DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.
Frontiers in bioscience : a journal and virtual library 2008;13():2356-63.
2007: Bank Ute; Tadje Janine; Täger Michael; Wolke Carmen; Bukowska Alicja; Ittenson Annelore; Reinhold Dirk; Helmuth Martin; Ansorge Siegfried; Shakespeare Ann; Vieth Michael; Malfertheiner Peter; Naumann Michael; Lendeckel Uwe
Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice.
International journal of molecular medicine 2007;20(4):483-92.
2007: Reinhold Dirk; Biton Aliza; Goihl Alexander; Pieper Stefanie; Lendeckel Uwe; Faust Jürgen; Neubert Klaus; Bank Ute; Täger Michael; Ansorge Siegfried; Brocke Stefan
Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses.
Annals of the New York Academy of Sciences 2007;1110():402-9.
2007: Thielitz Anja; Reinhold Dirk; Vetter Robert; Bank Ute; Helmuth Martin; Hartig Roland; Wrenger Sabine; Wiswedel Ingrid; Lendeckel Uwe; Kähne Thilo; Neubert Klaus; Faust Jürgen; Zouboulis Christos C; Ansorge Siegfried; Gollnick Harald
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation.
The Journal of investigative dermatology 2007;127(5):1042-51.
2007: Preller Vera; Gerber Annegret; Wrenger Sabine; Togni Mauro; Marguet Didier; Tadje Janine; Lendeckel Uwe; Röcken Christoph; Faust Jürgen; Neubert Klaus; Schraven Burkhart; Martin Roland; Ansorge Siegfried; Brocke Stefan; Reinhold Dirk
TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4632-40.
2006: Reinhold Dirk; Biton Aliza; Pieper Stefanie; Lendeckel Uwe; Faust Jürgen; Neubert Klaus; Bank Ute; Täger Michael; Ansorge Siegfried; Brocke Stefan
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
International immunopharmacology 2006;6(13-14):1935-42.
2006: Bank Ute; Heimburg Anke; Helmuth Martin; Stefin Sofia; Lendeckel Uwe; Reinhold Dirk; Faust Jürgen; Fuchs Petra; Sens Bianca; Neubert Klaus; Täger Michael; Ansorge Siegfried
Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease.
International immunopharmacology 2006;6(13-14):1925-34.
2006: Schneider Thomas; Sailer Michael; Ansorge Siegfried; Firsching Raimund; Reinhold Dirk
Increased concentrations of transforming growth factor beta1 and beta2 in the plasma of patients with glioblastoma.
Journal of neuro-oncology 2006;79(1):61-5.
2006: Wolke Carmen; Tadje Janine; Bukowska Alicja; Täger Michael; Bank Ute; Ittenson Annelore; Ansorge Siegfried; Lendeckel Uwe
Assigning the phenotype of a natural regulatory T-cell to the human T-cell line, KARPAS-299.
International journal of molecular medicine 2006;17(2):275-8.
2006: Preller Vera; Gerber Annegret; Togni Mauro; Wrenger Sabine; Schraven Burkhart; Röcken Christoph; Marguet Didier; Ansorge Siegfried; Brocke Stefan; Reinhold Dirk
CD26/DP IV in T cell activation and autoimmunity.
Advances in experimental medicine and biology 2006;575():187-93.
2006: Biton Aliza; Bank Ute; Täger Michael; Ansorge Siegfried; Reinhold Dirk; Lendeckel Uwe; Brocke Stefan
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
Advances in experimental medicine and biology 2006;575():177-86.
2006: Thielitz Anja; Reinhold Dirk; Vetter Robert; Lendeckel Uwe; Kähne Thilo; Bank Ute; Helmuth Martin; Neubert Klaus; Faust Jürgen; Hartig Roland; Wrenger Sabine; Zouboulis Christos C; Ansorge Siegfried; Gollnick Harald
Possible role of DP IV inhibitors in acne therapy.
Advances in experimental medicine and biology 2006;575():163-7.
2006: Bank Ute; Tadje Janine; Helmuth Martin; Stefin Sofia; Täger Michael; Wolke Carmen; Wischeropp Anke; Ittenson Annelore; Reinhold Dirk; Ansorge Siegfried; Lendeckel Uwe
Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases-proof of concept in a mouse model of colitis.
Advances in experimental medicine and biology 2006;575():143-53.
2005: Schneemilch Christine E; Ittenson Annelore; Ansorge Siegfried; Hachenberg Thomas; Bank Ute
Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery.
Journal of clinical anesthesia 2005;17(7):517-27.
2005: Schneemilch C E; Hachenberg T; Ansorge S; Ittenson A; Bank U
Effects of different anaesthetic agents on immune cell function in vitro.
European journal of anaesthesiology 2005;22(8):616-23.
2005: Schmidt-Lucke Caroline; Belgore Funmi; Reinhold Dirk; Ansorge Siegfried; Klein Helmut U; Schmidt-Lucke J André; Lip Gregory Y H
Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers.
International journal of cardiology 2005;100(2):207-12.
2004: Thielitz Anja; Bukowska A; Wolke C; Vetter Robert; Lendeckel Uwe; Wrenger Sabine; Hashimoto Yuichi; Ansorge Siegfried; Gollnick Harald; Reinhold Dirk
Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation.
Biochemical and biophysical research communications 2004;321(4):795-801.
2004: Bühling F; Koch G; Wex T; Heimburg A; Vieth M; Leodolter A; Roessner A; Ansorge S; Malfertheiner P
Simultaneous detection and differentiation of anti-Helicobacter pylori antibodies by flow microparticle immunofluorescence assay.
Clinical and diagnostic laboratory immunology 2004;11(1):131-6.
2003: Lorey Susan; Stöckel-Maschek Angela; Faust Jürgen; Brandt Wolfgang; Stiebitz Beate; Gorrell Mark D; Kähne Thilo; Mrestani-Klaus Carmen; Wrenger Sabine; Reinhold Dirk; Ansorge Siegfried; Neubert Klaus
Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites.
European journal of biochemistry / FEBS 2003;270(10):2147-56.
2003: Bernstein Hans-Gert; Bukowska Alicja; Krell Dieter; Bogerts Bernhard; Ansorge Siegfried; Lendeckel Uwe
Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome.
Journal of neurocytology 2003;32(2):153-60.
2003: Schmidt-Lucke Caroline; Reinhold Dirk; Ansorge Siegfried; Klein Helmut U; Schmidt-Lucke J André
Changes of plasma concentrations of soluble vascular cell adhesion molecule-1 and vascular endothelial growth factor after increased perfusion of lower extremities in humans.
Endothelium : journal of endothelial cell research 2003;10(3):159-65.
2003: Böhm M; Ittenson A; Klatte T; Schierbaum K F; Röhl F W; Ansorge S; Allhoff E P
Pretreatment with interleukin-2 modulates perioperative immunodysfunction in patients with renal cell carcinoma.
Folia biologica 2003;49(2):63-8.
2003: Faust Jürgen; Fuchs Petra; Wrenger Sabine; Reinhold Dirk; Stöckel-Maschek Angela; Kähne Thilo; Ansorge Siegfried; Neubert Klaus
Dipeptidyl peptidase IV inhibitors with the N-terminal MXP sequence: structure-activity-relationships.
Advances in experimental medicine and biology 2003;524():175-9.
2003: Lendeckel Uwe; Arndt Marco; Bukowska Alicja; Tadje Janine; Wolke Carmen; Kähne Thilo; Neubert Klaus; Faust Jürgen; Ittenson Annelore; Ansorge Siegfried; Reinhold Dirk
Synergistic action of DPIV and APN in the regulation of T cell function.
Advances in experimental medicine and biology 2003;524():123-31.
2003: Mrestani-Klaus Carmen; Brandt Wolfgang; Faust Jürgen; Wrenger Sabine; Reinhold Dirk; Ansorge Siegfried; Neubert Klaus
New results on the conformations of potent DP IV (CD26) inhibitors bearing the N-terminal MWP structural motif.
Advances in experimental medicine and biology 2003;524():65-8.
2002: Dietzmann Jörn; Thiel Ute; Ansorge Siegfried; Neumann Klaus Hinrich; Täger Michael
Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy.
Free radical biology & medicine 2002;33(10):1347-54.
2002: Lorey Susan; Faust Jurgen; Mrestani-Klaus Carmen; Kähne Thilo; Ansorge Siegfried; Neubert Klaus; Bühling Frank
Transcellular proteolysis demonstrated by novel cell surface-associated substrates of dipeptidyl peptidase IV (CD26).
The Journal of biological chemistry 2002;277(36):33170-7.
2002: Reinhold Dirk; Kähne Thilo; Steinbrecher Andreas; Wrenger Sabine; Neubert Klaus; Ansorge Siegfried; Brocke Stefan
The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity.
Biological chemistry 2002;383(7-8):1133-8.
2002: Goette Andreas; Arndt Marco; Röcken Christoph; Staack Thorsten; Bechtloff Roland; Reinhold Dirk; Huth Christof; Ansorge Siegfried; Klein Helmut U; Lendeckel Uwe
Calpains and cytokines in fibrillating human atria.
American journal of physiology. Heart and circulatory physiology 2002;283(1):H264-72.
2002: Böhm M; Ittenson A; Schierbaum K F; Röhl F-W; Ansorge S; Allhoff E P
Pretreatment with interleukin-2 modulates peri-operative immuno-dysfunction in patients with renal cell carcinoma.
European urology 2002;41(4):458-67; discussion 467-8.
2002: Firla Beate; Arndt Marco; Frank Karin; Thiel Ute; Ansorge Siegfried; Täger Michael; Lendeckel Uwe
Extracellular cysteines define ectopeptidase (APN, CD13) expression and function.
Free radical biology & medicine 2002;32(7):584-95.
2002: Arndt Marco; Lendeckel Uwe; Röcken Christoph; Nepple Karen; Wolke Carmen; Spiess Antje; Huth Christof; Ansorge Siegfried; Klein Helmut U; Goette Andreas
Altered expression of ADAMs (A Disintegrin And Metalloproteinase) in fibrillating human atria.
Circulation 2002;105(6):720-5.
2002: Lendeckel Uwe; Arndt Marco; Wolke Carmen; Reinhold Dirk; Kähne Thilo; Ansorge Siegfried
Inhibition of human leukocyte function, alanyl aminopeptidase (APN, CD13) and dipeptidylpeptidase IV (DP IV, CD26) enzymatic activities by aqueous extracts of Cistus incanus L. ssp. incanus.
Journal of ethnopharmacology 2002;79(2):221-7.
2001: Frass O M; Bühling F; Täger M; Frass H; Ansorge S; Huth C; Welte T
Antioxidant and antiprotease status in peripheral blood and BAL fluid after cardiopulmonary bypass.
Chest 2001;120(5):1599-608.
2001: Bühling F; Reisenauer A; Gerber A; Krüger S; Weber E; Brömme D; Roessner A; Ansorge S; Welte T; Röcken C
Cathepsin K--a marker of macrophage differentiation?
The Journal of pathology 2001;195(3):375-82.
2001: Böhm M; Ittenson A; Philipp C; Röhl F W; Ansorge S; Allhoff E P
Complex perioperative immuno-dysfunction in patients with renal cell carcinoma.
The Journal of urology 2001;166(3):831-6.
2001: Lendeckel U; Arndt M; Wrenger S; Nepple K; Huth C; Ansorge S; Klein H U; Goette A
Expression and activity of ectopeptidases in fibrillating human atria.
Journal of molecular and cellular cardiology 2001;33(6):1273-81.
2001: Röcken C; Stix B; Brömme D; Ansorge S; Roessner A; Bühling F
A putative role for cathepsin K in degradation of AA and AL amyloidosis.
The American journal of pathology 2001;158(3):1029-38.
2001: Täger M; Dietzmann J; Thiel U; Hinrich Neumann K; Ansorge S
Restoration of the cellular thiol status of peritoneal macrophages from CAPD patients by the flavonoids silibinin and silymarin.
Free radical research 2001;34(2):137-51.
2001: Steinbrecher A; Reinhold D; Quigley L; Gado A; Tresser N; Izikson L; Born I; Faust J; Neubert K; Martin R; Ansorge S; Brocke S
Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta 1 secretion in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):2041-8.
2001: Gerber A; Wille A; Welte T; Ansorge S; Bühling F
Interleukin-6 and transforming growth factor-beta 1 control expression of cathepsins B and L in human lung epithelial cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(1):11-9.
2000: Gerber A; Struy H; Weiss G; Lippert H; Ansorge S; Schulz H U
Effect of granulocyte colony-stimulating factor treatment on ex vivo neutrophil functions in nonneutropenic surgical intensive care patients.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(12):1083-90.
2000: Täger M; Piecyk A; Köhnlein T; Thiel U; Ansorge S; Welte T
Evidence of a defective thiol status of alveolar macrophages from COPD patients and smokers. Chronic obstructive pulmonary disease.
Free radical biology & medicine 2000;29(11):1160-5.
2000: Goette A; Ittenson A; Hoffmanns P; Reek S; Hartung W; Klein H; Ansorge S; Geller J C
Increased expression of P-selectin in patients with chronic atrial fibrillation.
Pacing and clinical electrophysiology : PACE 2000;23(11 Pt 2):1872-5.
2000: Arndt M; Lendeckel U; Spiess A; Faust J; Neubert K; Reinhold D; Ansorge S
Dipeptidyl peptidase IV (DP IV/CD26) mRNA expression in PWM-stimulated T-cells is suppressed by specific DP IV inhibition, an effect mediated by TGF-beta(1).
Biochemical and biophysical research communications 2000;274(2):410-4.
2000: Wrenger S; Faust J; Mrestani-Klaus C; Fengler A; Stockel-Maschek A; Lorey S; Kahne T; Brandt W; Neubert K; Ansorge S; Reinhold D
Down-regulation of T cell activation following inhibition of dipeptidyl peptidase IV/CD26 by the N-terminal part of the thromboxane A2 receptor.
The Journal of biological chemistry 2000;275(29):22180-6.
2000: Lendeckel U; Scholz B; Arndt M; Frank K; Spiess A; Chen H; Roques B P; Ansorge S
Inhibition of alanyl-aminopeptidase suppresses the activation-dependent induction of glycogen synthase kinase-3beta (GSK-3beta) in human T cells.
Biochemical and biophysical research communications 2000;273(1):62-5.
2000: Goette A; Arndt M; Röcken C; Spiess A; Staack T; Geller J C; Huth C; Ansorge S; Klein H U; Lendeckel U
Regulation of angiotensin II receptor subtypes during atrial fibrillation in humans.
Circulation 2000;101(23):2678-81.
2000: Goette A; Staack T; Röcken C; Arndt M; Geller J C; Huth C; Ansorge S; Klein H U; Lendeckel U
Increased expression of extracellular signal-regulated kinase and angiotensin-converting enzyme in human atria during atrial fibrillation.
Journal of the American College of Cardiology 2000;35(6):1669-77.
2000: Ansorge S; Langner J; Bühling F; Lendeckel U
Proteolytic signals from Magdeburg.
Immunology today 2000;21(4):166-7.
2000: Bühling F; Ittenson A; Kaiser D; Thölert G; Hoffmann B; Reinhold D; Ansorge S; Welte T
MRP8/MRP14, CD11b and HLA-DR expression of alveolar macrophages in pneumonia.
Immunology letters 2000;71(3):185-90.
2000: Wrenger S; Kähne T; Bohuon C; Weglöhner W; Ansorge S; Reinhold D
Amino-terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV (DP IV).
FEBS letters 2000;466(1):155-9.
2000: Gerber A; Bohne M; Rasch J; Struy H; Ansorge S; Gollnick H
Investigation of annexin V binding to lymphocytes after extracorporeal photoimmunotherapy as an early marker of apoptosis.
Dermatology (Basel, Switzerland) 2000;201(2):111-7.
2000: Gottschalk C; Malberg K; Arndt M; Schmitt J; Roessner A; Schultze D; Kleinstein J; Ansorge S
Matrix metalloproteinases and TACE play a role in the pathogenesis of endometriosis.
Advances in experimental medicine and biology 2000;477():483-6.
2000: Bank U; Küpper B; Ansorge S
Inactivation of interleukin-6 by neutrophil proteases at sites of inflammation. Protective effects of soluble IL-6 receptor chains.
Advances in experimental medicine and biology 2000;477():431-7.
2000: Gerber A; Welte T; Ansorge S; Bühling F
Expression of cathepsins B and L in human lung epithelial cells is regulated by cytokines.
Advances in experimental medicine and biology 2000;477():287-92.
2000: Bühling F; Waldburg N; Gerber A; Häckel C; Krüger S; Reinhold D; Brömme D; Weber E; Ansorge S; Welte T
Cathepsin K expression in human lung.
Advances in experimental medicine and biology 2000;477():281-6.
2000: Bühling F; Fengler A; Brandt W; Welte T; Ansorge S; Nägler D K
Review: novel cysteine proteases of the papain family.
Advances in experimental medicine and biology 2000;477():241-54.
2000: Vetter R; Reinhold D; Bühling F; Lendeckel U; Born I; Faust J; Neubert K; Ansorge S; Gollnick H
DNA synthesis in cultured human keratinocytes and HaCaT keratinocytes is reduced by specific inhibition of dipeptidyl peptidase IV (CD26) enzymatic activity.
Advances in experimental medicine and biology 2000;477():167-71.
2000: Wrenger S; Reinhold D; Faust J; Mrestani-Klaus C; Brandt W; Fengler A; Neubert K; Ansorge S
Effects of nonapeptides derived from the N-terminal structure of human immunodeficiency virus-1 (HIV-1) Tat on suppression of CD26-dependent T cell growth.
Advances in experimental medicine and biology 2000;477():161-5.
2000: Reinhold D; Hemmer B; Gran B; Steinbrecher A; Brocke S; Kähne T; Wrenger S; Born I; Faust J; Neubert K; Martin R; Ansorge S
Dipeptidyl peptidase IV (CD26): role in T cell activation and autoimmune disease.
Advances in experimental medicine and biology 2000;477():155-60.
2000: Steinbrecher A; Reinhold D; Quigley L; Gado A; Tresser N; Izikson L; Born I; Faust J; Neubert K; Martin R; Ansorge S; Brocke S
Dipeptidyl peptidase IV in inflammatory CNS disease.
Advances in experimental medicine and biology 2000;477():145-53.
2000: Arndt M; Reinhold D; Lendeckel U; Spiess A; Faust J; Neubert K; Ansorge S
Specific inhibitors of dipeptidyl peptidase IV suppress mRNA expression of DP IV/CD26 and cytokines.
Advances in experimental medicine and biology 2000;477():139-43.
2000: Kähne T; Reinhold D; Neubert K; Born I; Faust J; Ansorge S
Signal transduction events induced or affected by inhibition of the catalytic activity of dipeptidyl peptidase IV (DP IV, CD26).
Advances in experimental medicine and biology 2000;477():131-7.
2000: Mrestani-Klaus C; Fengler A; Faust J; Brandt W; Wrenger S; Reinhold D; Ansorge S; Neubert K
N-terminal HIV-1 Tat nonapeptides as inhibitors of dipeptidyl peptidase IV. Conformational characterization.
Advances in experimental medicine and biology 2000;477():125-9.
2000: Lorey S; Faust J; Bühling F; Ansorge S; Neubert K
A new type of fluorogenic substrates for determination of cellular dipeptidyl peptidase IV (DP IV/CD26) activity.
Advances in experimental medicine and biology 2000;477():111-5.
2000: Lendeckel U; Arndt M; Frank K; Spiess A; Reinhold D; Ansorge S
Modulation of WNT-5A expression by actinonin: linkage of APN to the WNT-pathway?
Advances in experimental medicine and biology 2000;477():35-41.
1999: Grüngreiff K; Reinhold D; Ansorge S
Serum concentrations of sIL-2R, IL-6, TGF-beta1, neopterin, and zinc in chronic hepatitis C patients treated with interferon-alpha.
Cytokine 1999;11(12):1076-80.
1999: Bank U; Reinhold D; Schneemilch C; Kunz D; Synowitz H J; Ansorge S
Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(11):1277-87.
1999: Bank U; Küpper B; Reinhold D; Hoffmann T; Ansorge S
Evidence for a crucial role of neutrophil-derived serine proteases in the inactivation of interleukin-6 at sites of inflammation.
FEBS letters 1999;461(3):235-40.
1999: Bühling F; Gerber A; Ansorge S; Welte T
[Cathepsin cysteine proteinases in the lung]
Pneumologie (Stuttgart, Germany) 1999;53(8):400-7.
1999: Arndt M; Bank U; Frank K; Sabel B A; Ansorge S; Lendeckel U
R-esp1, a rat homologue of drosophila groucho, is differentially expressed after optic nerve crush and mediates NGF-induced survival of PC12 cells.
FEBS letters 1999;457(2):246-50.
1999: Reinhold D; Wrenger S; Kähne T; Ansorge S
HIV-1 Tat: immunosuppression via TGF-beta1 induction.
Immunology today 1999;20(8):384-5.
1999: Lendeckel U; Arndt M; Frank K; Wex T; Ansorge S
Role of alanyl aminopeptidase in growth and function of human T cells (review).
International journal of molecular medicine 1999;4(1):17-27.
1999: Kahne T; Lendeckel U; Wrenger S; Neubert K; Ansorge S; Reinhold D
Dipeptidyl peptidase IV: a cell surface peptidase involved in regulating T cell growth (review).
International journal of molecular medicine 1999;4(1):3-15.
1999: Bühling F; Gerber A; Häckel C; Krüger S; Köhnlein T; Brömme D; Reinhold D; Ansorge S; Welte T
Expression of cathepsin K in lung epithelial cells.
American journal of respiratory cell and molecular biology 1999;20(4):612-9.
1999: Bühling F; Thölert G; Kaiser D; Hoffmann B; Reinhold D; Ansorge S; Welte T
Increased release of transforming growth factor (TGF)-beta1, TGF-beta2, and chemoattractant mediators in pneumonia.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(3):271-8.
1999: Bernstein H G; Ansorge S; Riederer P; Reiser M; Frölich L; Bogerts B
Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques.
Neuroscience letters 1999;263(2-3):161-4.
1999: Reinhold D; Ansorge S; Grüngreiff K
Immunobiology of zinc and zinc therapy.
Immunology today 1999;20(2):102-3.
1998: Lendeckel U; Kähne T; Arndt M; Frank K; Ansorge S
Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299.
Biochemical and biophysical research communications 1998;252(1):5-9.
1998: Kähne T; Neubert K; Faust J; Ansorge S
Early phosphorylation events induced by DPIV/CD26-specific inhibitors.
Cellular immunology 1998;189(1):60-6.
1998: Mrestani-Klaus C; Fengler A; Brandt W; Faust J; Wrenger S; Reinhold D; Ansorge S; Neubert K
1H NMR conformational study on N-terminal nonapeptide sequences of HIV-1 Tat protein: a contribution to structure-activity relationships.
Journal of peptide science : an official publication of the European Peptide Society 1998;4(6):400-10.
1998: Reinhold D; Hemmer B; Gran B; Born I; Faust J; Neubert K; McFarland H F; Martin R; Ansorge S
Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones.
Journal of neuroimmunology 1998;87(1-2):203-9.
1998: Reinhold D; Vetter R W; Mnich K; Bühling F; Lendeckel U; Born I; Faust J; Neubert K; Gollnick H; Ansorge S
Dipeptidyl peptidase IV (DP IV, CD26) is involved in regulation of DNA synthesis in human keratinocytes.
FEBS letters 1998;428(1-2):100-4.
1998: Lendeckel U; Wex T; Arndt M; Frank K; Franke A; Ansorge S
Identification of point mutations in the aminopeptidase N gene by SSCP analysis and sequencing.
Human mutation 1998;Suppl 1():S158-60.
1997: Schulz S; Reinhold D; Schmidt H; Ansorge S; Höllt V
Perillic acid inhibits Ras/MAP kinase-driven IL-2 production in human T lymphocytes.
Biochemical and biophysical research communications 1997;241(3):720-5.
1997: Wrenger S; Hoffmann T; Faust J; Mrestani-Klaus C; Brandt W; Neubert K; Kraft M; Olek S; Frank R; Ansorge S; Reinhold D
The N-terminal structure of HIV-1 Tat is required for suppression of CD26-dependent T cell growth.
The Journal of biological chemistry 1997;272(48):30283-8.
1997: Reinhold D; Bank U; Bühling F; Lendeckel U; Faust J; Neubert K; Ansorge S
Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells.
Immunology 1997;91(3):354-60.
1997: Wex T; Bühling F; Arndt M; Frank K; Ansorge S; Lendeckel U
The activation-dependent induction of APN-(CD13) in T-cells is controlled at different levels of gene expression.
FEBS letters 1997;412(1):53-6.
1997: Täger M; Kröning H; Thiel U; Ansorge S
Membrane-bound proteindisulfide isomerase (PDI) is involved in regulation of surface expression of thiols and drug sensitivity of B-CLL cells.
Experimental hematology 1997;25(7):601-7.
1997: Reinhold D; Bank U; Bühling F; Täger M; Born I; Faust J; Neubert K; Ansorge S
Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes.
Immunology letters 1997;58(1):29-35.
1997: Lendeckel U; Wex T; Ittenson A; Arndt M; Frank K; Mayboroda O; Schubert W; Ansorge S
Rapid mitogen-induced aminopeptidase N surface expression in human T cells is dominated by mechanisms independent of de novo protein biosynthesis.
Immunobiology 1997;197(1):55-69.
1997: Wex T; Lendeckel U; Kähne T; Ittenson A; Frank K; Ansorge S
The main neutral aminopeptidase activity of human lymphoid tumour cell lines does not originate from the aminopeptidase N-(APN; CD13) gene.
Biochimica et biophysica acta 1997;1355(2):147-54.
1997: Bank U; Reinhold D; Kunz D; Ansorge S
Selective proteolytical cleavage of the ligand-binding chains of the IL-2-receptor and IL-6-receptor by neutrophil-derived proteases.
Advances in experimental medicine and biology 1997;421():231-42.
1997: Lorey S; Faust J; Hermanns U; Bühling F; Ansorge S; Neubert K
New fluorogenic dipeptidyl peptidase IV/CD26 substrates and inhibitors.
Advances in experimental medicine and biology 1997;421():157-60.
1997: Reinhold D; Kähne T; Täger M; Lendeckel U; Bühling F; Bank U; Wrenger S; Faust J; Neubert K; Ansorge S
The effect of anti-CD26 antibodies on DNA synthesis and cytokine production (IL-2, IL-10 and IFN-gamma) depends on enzymatic activity of DP IV/CD26.
Advances in experimental medicine and biology 1997;421():149-55.
1997: Bühling F; Reinhold D; Lendeckel U; Faust J; Neubert K; Ansorge S
CD26 is involved in regulation of cytokine production in natural killer cells.
Advances in experimental medicine and biology 1997;421():141-7.
1997: Ansorge S; Bühling F; Kähne T; Lendeckel U; Reinhold D; Täger M; Wrenger S
CD26/dipeptidyl peptidase IV in lymphocyte growth regulation.
Advances in experimental medicine and biology 1997;421():127-40.
1997: Wex T; Lendeckel U; Reinhold D; Kähne T; Arndt M; Frank K; Ansorge S
Antisense-mediated inhibition of aminopeptidase N (CD13) markedly decreases growth rates of hematopoietic tumour cells.
Advances in experimental medicine and biology 1997;421():67-73.
1997: Lendeckel U; Wex T; Reinhold D; Arndt M; Ittenson A; Frank K; Ansorge S
Activation-dependent induction of T cell alanyl aminopeptidase and its possible involvement in T cell growth.
Advances in experimental medicine and biology 1997;421():59-66.
1996: Lendeckel U; Wex T; Reinhold D; Kähne T; Frank K; Faust J; Neubert K; Ansorge S
Induction of the membrane alanyl aminopeptidase gene and surface expression in human T-cells by mitogenic activation.
The Biochemical journal 1996;319 ( Pt 3)():817-21.
1996: Fritz S; Striggow F; Reinhold D; Schlüter T; Schönfeld P; Ansorge S; Bohnensack R
Phorbol ester-induced shedding of intercellular adhesion molecule-1 (ICAM-1) on erythroleukemic K 562 cells.
Biochimica et biophysica acta 1996;1312(3):255-61.
1996: Kähne T; Kröning H; Thiel U; Ulmer A J; Flad H D; Ansorge S
Alterations in structure and cellular localization of molecular forms of DP IV/CD26 during T cell activation.
Cellular immunology 1996;170(1):63-70.
1996: Wrenger S; Reinhold D; Hoffmann T; Kraft M; Frank R; Faust J; Neubert K; Ansorge S
The N-terminal X-X-Pro sequence of the HIV-1 Tat protein is important for the inhibition of dipeptidyl peptidase IV (DP IV/CD26) and the suppression of mitogen-induced proliferation of human T cells.
FEBS letters 1996;383(3):145-9.
1996: Reinhold D; Wrenger S; Bank U; Bühling F; Hoffmann T; Neubert K; Kraft M; Frank R; Ansorge S
CD26 mediates the action of HIV-1 Tat protein on DNA synthesis and cytokine production in U937 cells.
Immunobiology 1996;195(1):119-28.
1996: Lendeckel U; Wex T; Frank K; Daoud A; Franke A; Ansorge S
Detection of residual leukemic cells in acute lymphocytic leukemia of B-cells (B-ALL) by a nonradioactive PCR-based technique.
Cancer detection and prevention 1996;20(3):185-92.
1995: Hoffmann T; Reinhold D; Kähne T; Faust J; Neubert K; Frank R; Ansorge S
Inhibition of dipeptidyl peptidase IV (DP IV) by anti-DP IV antibodies and non-substrate X-X-Pro- oligopeptides ascertained by capillary electrophoresis.
Journal of chromatography. A 1995;716(1-2):355-62.
1995: Wex T; Lendeckel U; Wex H; Frank K; Ansorge S
Quantification of aminopeptidase N mRNA in T cells by competitive PCR.
FEBS letters 1995;374(3):341-4.
1995: Reinhold D; Bank U; Bühling F; Lendeckel U; Ansorge S
Transforming growth factor beta 1 inhibits interleukin-10 mRNA expression and production in pokeweed mitogen-stimulated peripheral blood mononuclear cells and T cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(8):685-90.
1995: Täger M; Ittenson A; Franke A; Frey A; Gassen H G; Ansorge S
gamma-Glutamyl transpeptidase-cellular expression in populations of normal human mononuclear cells and patients suffering from leukemias.
Annals of hematology 1995;70(5):237-42.
1995: Kähne T; Neubert K; Ansorge S
Enzymatic activity of DPIV/CD26 is involved in PMA-induced hyperphosphorylation of p56lck.
Immunology letters 1995;46(1-2):189-93.
1995: Mattern T; Reich C; Duchrow M; Ansorge S; Ulmer A J; Flad H D
Antibody-induced modulation of CD26 surface expression.
Immunology 1995;84(4):595-600.
1995: Bank U; Reinhold D; Kunz D; Schulz H U; Schneemilch C; Brandt W; Ansorge S
Effects of interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) on neutrophil elastase release.
Inflammation 1995;19(1):83-99.
1995: Bühling F; Junker U; Reinhold D; Neubert K; Jäger L; Ansorge S
Functional role of CD26 on human B lymphocytes.
Immunology letters 1995;45(1-2):47-51.
1994: Reinhold D; Bank U; Bühling F; Kähne T; Kunt D; Faust J; Neubert K; Ansorge S
Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) specifically suppress proliferation and modulate cytokine production of strongly CD26 expressing U937 cells.
Immunobiology 1994;192(1-2):121-36.
1994: Bühling F; Kunz D; Reinhold D; Ulmer A J; Ernst M; Flad H D; Ansorge S
Expression and functional role of dipeptidyl peptidase IV (CD26) on human natural killer cells.
Natural immunity 1994;13(5):270-9.
1994: Reinhold D; Bank U; Bühling F; Lendeckel U; Ulmer A J; Flad H D; Ansorge S
Transforming growth factor-beta 1 (TGF-beta 1) inhibits DNA synthesis of PWM-stimulated PBMC via suppression of IL-2 and IL-6 production.
Cytokine 1994;6(4):382-8.
1994: Kröning H; Kähne T; Ittenson A; Franke A; Ansorge S
Thiol-proteindisulfide-oxidoreductase (proteindisulfide isomerase): a new plasma membrane constituent of mature human B lymphocytes.
Scandinavian journal of immunology 1994;39(4):346-50.
1994: Schulz S; Bühling F; Ansorge S
Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene related monoterpenes.
European journal of immunology 1994;24(2):301-7.
1994: Lendeckel U; Wex T; Kähne T; Frank K; Reinhold D; Ansorge S
Expression of the aminopeptidase N (CD13) gene in the human T cell lines HuT78 and H9.
Cellular immunology 1994;153(1):214-26.
1993: Hoffmann T; Faust J; Neubert K; Ansorge S
Dipeptidyl peptidase IV (CD 26) and aminopeptidase N (CD 13) catalyzed hydrolysis of cytokines and peptides with N-terminal cytokine sequences.
FEBS letters 1993;336(1):61-4.
1993: Reinhold D; Bank U; Bühling F; Neubert K; Mattern T; Ulmer A J; Flad H D; Ansorge S
Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells, and IL-2 and IL-6 production.
Immunobiology 1993;188(4-5):403-14.
1993: Mattern T; Ansorge S; Flad H D; Ulmer A J
Anti-CD26 monoclonal antibodies can reversibly arrest human T lymphocytes in the late G1 phase of the cell cycle.
Immunobiology 1993;188(1-2):36-50.
1993: Kunz D; Bühling F; Hütter H J; Aoyagi T; Ansorge S
Aminopeptidase N (CD13, EC 3.3.4.11.2) occurs on the surface of resting and concanavalin A-stimulated lymphocytes.
Biological chemistry Hoppe-Seyler 1993;374(4):291-6.
1991: Kröning H; Thiel U; Ansorge S
Induction of protein disulphide-isomerase and immunoglobulins by pokeweed mitogen in human lymphocytes.
Hybridoma 1991;10(6):651-7.
1991: Schön E; Born I; Demuth H U; Faust J; Neubert K; Steinmetzer T; Barth A; Ansorge S
Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes.
Biological chemistry Hoppe-Seyler 1991;372(5):305-11.
1991: Küster U; Kunert M; Schönborn I; Weber P; Heyer G; Mansfeld H W; Ittenson A; Ansorge S
[Biofreezer BF 80--a universally employed apparatus in preservation at very low temperatures]
Zeitschrift für medizinische Laboratoriumsdiagnostik 1991;32(3-4):204-8.
1991: Kröning H; Mansfeld H W; Held C; Thiel U; Ansorge S
[Immunochemical determination of human thiol protein disulfide oxidoreductase in cell and tissue homogenates by competitive EIA]
Allergie und Immunologie 1991;37(2):89-96.
1991: Bank U; Reinhold D; Ansorge S
[Measurement of cellular activity with the MTT test. Optimization of the method]
Allergie und Immunologie 1991;37(3-4):119-23.
1991: Ansorge S; Schön E; Kunz D
Membrane-bound peptidases of lymphocytes: functional implications.
Biomedica biochimica acta 1991;50(4-6):799-807.
1990: Mansfield H W; Ansorge S
[Staphylococcus aureus (STA), a B- and T-cell mitogen]
Allergie und Immunologie 1990;36(4):367-73.
1990: Reinhold D; Ansorge S
[IL-2 production by peripheral blood mononuclear cells after stimulation with pokeweed mitogen]
Allergie und Immunologie 1990;36(4):293-8.
1990: Kunz D; Schön E; Hütter H J; Ansorge S
[Aminopeptidase activity in populations of human blood mononuclear cells]
Allergie und Immunologie 1990;36(4):233-43.
1990: Wendt C; Schön E; Gaede B; Franke A; Ansorge S
[Characterization of T lymphocyte defects in patients with Hodgkin's disease using enzyme chemical markers]
Folia haematologica (Leipzig, Germany : 1928) 1990;117(6):851-7.
1989: Götze D; Neuendorf R; Kleine F D; Ittenson A; Mansfeld H W; Schön E; Ansorge S
[Determination of cellular and humoral parameters of fatty liver]
Allergie und Immunologie 1989;35(1):65-8.
1988: Küster U; Fiebig H; Ansorge S
Direct immunogold staining technique based on monoclonal antibodies: an immediate approach to the immunostaining of lymphocytes.
Acta histochemica 1988;84(1):23-9.
1987: Schön E; Jahn S; Kiessig S T; Demuth H U; Neubert K; Barth A; Von Baehr R; Ansorge S
The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro.
European journal of immunology 1987;17(12):1821-6.
1987: Ittenson A; Mansfeld H W; Ansorge S
[Fc-IgG and Fc-IgM receptor-carrying lymphocytes in human blood. Optimization of determining T(M) lymphocytes]
Allergie und Immunologie 1987;33(1):53-62.
1987: Ansorge S; Schön E
Dipeptidyl peptidase IV (DP IV), a functional marker of the T lymphocyte system.
Acta histochemica 1987;82(1):41-6.
1986: Götze D; Held C; Klemm K; Mansfeld H W; Schön E; Ansorge S
The thiol-proteindisulfide-oxidoreductase--a new marker enzyme of monocytes from peripheral blood.
Allergie und Immunologie 1986;32(4):227-31.
1986: Schön E; Eichmann E; Grunow R; Jahn S; Kiessig S T; Volk H D; Ansorge S
Dipeptidyl peptidase IV in human T lymphocytes. An approach to the role of a membrane peptidase in the immune system.
Biomedica biochimica acta 1986;45(11-12):1523-8.
1986: Mansfeld H W; Götze D; Ittenson A; Schön E; Ansorge S
[Application of dextran M 70 for the production of mononuclear cells. Comparative studies on the distribution of markers of subpopulations of mononuclear cells from human peripheral blood]
Zeitschrift für medizinische Laboratoriumsdiagnostik 1986;27(4):225-7.
1986: Ansorge S; Mansfeld H W; Held C; Broodtaerts L; van Camp B
The thiol-proteindisulfide oxidoreductase in human mononuclear cells of blood and bone marrow.
Acta histochemica 1986;78(1):65-71.
1985: Schön E; Götze D; Mansfeld H W; Trappe C; Lambrecht R; Ansorge S
[Comparative studies of the determination of T lymphocytes in human peripheral blood]
Allergie und Immunologie 1985;31(2):91-104.
1985: Götze D; Held C; Klemm K; Mansfeld H W; Schmidt D; Schön E; Ansorge S
[Isolation of monocytes by adherence to gelatin-layered surfaces]
Allergie und Immunologie 1985;31(3):189-93.
1985: Schön E; Mansfeld H W; Demuth H U; Barth A; Ansorge S
The dipeptidyl peptidase IV, a membrane enzyme involved in the proliferation of T lymphocytes.
Biomedica biochimica acta 1985;44(2):K9-15.
1985: Götze D; Fiebig H; Mansfeld H W; Mey U; Schön E; Uhle R; Ansorge S
Comparison of different markers on blood lymphocytes of chronic lymphocytic leukemia.
Folia haematologica (Leipzig, Germany : 1928) 1985;112(2):233-40.
1984: Schön E; Demuth H U; Barth A; Ansorge S
Dipeptidyl peptidase IV of human lymphocytes. Evidence for specific hydrolysis of glycylproline p-nitroanilide in T-lymphocytes.
The Biochemical journal 1984;223(1):255-8.
1984: Mansfeld H W; Götze D; Ittenson A; Schön E; Ansorge S
[Lymphocyte separation with dextran M 70]
Allergie und Immunologie 1984;30(3):188-90.
1984: Schön E; Ittenson A; Klemm K; Ansorge S
Dipeptidyl peptidase IV and alpha-naphthylacetate esterase in human T lymphocytes: cytochemical and biochemical investigations.
Acta histochemica 1984;75(2):175-82.

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