Christopher Fowler

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Maria Luisa Rojo; Antonio Rodriguez-Gaztelumendi; Christopher J Fowler
Lysophosphatidylinositol stimulates [³⁵S]GTPγS binding in the rat prefrontal cortex and hippocampus.
Christopher J Fowler
Anandamide uptake explained?
José A Cisneros; Emmelie Björklund; Inés González-Gil; Yanling Hu; Angeles Canales; Francisco J Medrano; Antonio Romero; Silvia Ortega-Gutiérrez; Christopher J Fowler; María L López-Rodríguez
Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.

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All Publications

2012: Maria Luisa Rojo; Antonio Rodriguez-Gaztelumendi; Christopher J Fowler
Lysophosphatidylinositol stimulates [³⁵S]GTPγS binding in the rat prefrontal cortex and hippocampus.
Neurochemical research 2012;37(5):1037-42.
2012: Christopher J Fowler
Anandamide uptake explained?
Trends in pharmacological sciences 2012;33(4):181-5.
2012: José A Cisneros; Emmelie Björklund; Inés González-Gil; Yanling Hu; Angeles Canales; Francisco J Medrano; Antonio Romero; Silvia Ortega-Gutiérrez; Christopher J Fowler; María L López-Rodríguez
Structure-activity relationship of a new series of reversible dual monoacylglycerol lipase/fatty acid amide hydrolase inhibitors.
Journal of medicinal chemistry 2012;55(2):824-36.
2011: Maria Luisa Rojo; Ingegerd Söderström; Christopher J Fowler
Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats.
Brain research 2011;1373():195-201.
2011: Emmelie Björklund; Sture Forsgren; Håkan Alfredson; Christopher J Fowler
Increased expression of cannabinoid CB₁ receptors in Achilles tendinosis.
PloS one 2011;6(9):e24731.
2011: Sofia B Gustafsson; Richard Palmqvist; Maria L Henriksson; Anna M Dahlin; Sofia Edin; Stig O P Jacobsson; Åke Öberg; Christopher J Fowler
High tumour cannabinoid CB1 receptor immunoreactivity negatively impacts disease-specific survival in stage II microsatellite stable colorectal cancer.
PloS one 2011;6(8):e23003.
2010: Christopher J Fowler; Maria Luisa Rojo; Antonio Rodriguez-Gaztelumendi
Modulation of the endocannabinoid system: neuroprotection or neurotoxicity?
Experimental neurology 2010;224(1):37-47.
2010: L Thors; J J Burston; B J Alter; M K McKinney; B F Cravatt; R A Ross; R G Pertwee; R W Gereau; J L Wiley; C J Fowler
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.
British journal of pharmacology 2010;160(3):549-60.
2010: Christopher J Fowler; Peter Hammarsten; Anders Bergh
Tumour Cannabinoid CB(1) receptor and phosphorylated epidermal growth factor receptor expression are additive prognostic markers for prostate cancer.
PloS one 2010;5(12):e15205.
2010: Lina Thors; Anders Bergh; Emma Persson; Peter Hammarsten; Pär Stattin; Lars Egevad; Torvald Granfors; Christopher J Fowler
Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4.
PloS one 2010;5(8):e12275.
2010: Christopher J Fowler; Sofia B Gustafsson; Sui Chu Chung; Emma Persson; Stig O P Jacobsson; Anders Bergh
Targeting the endocannabinoid system for the treatment of cancer--a practical view.
Current topics in medicinal chemistry 2010;10(8):814-27.
2009: Lina Thors; Christopher J Fowler
Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids.
European journal of pharmacology 2009;621(1-3):10-8.
2009: C J Fowler; P S Naidu; A Lichtman; V Onnis
The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1.
British journal of pharmacology 2009;156(3):412-9.
2008: L Thors; M Belghiti; C J Fowler
Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids.
British journal of pharmacology 2008;155(2):244-52.
2008: Christopher J Fowler; Nazdar Ghafouri
Does the hydrolysis of 2-arachidonoylglycerol regulate its cellular uptake?
Pharmacological research : the official journal of the Italian Pharmacological Society 2008;58(1):72-6.
2008: Christopher J Fowler
"The tools of the trade"--an overview of the pharmacology of the endocannabinoid system.
Current pharmaceutical design 2008;14(23):2254-65.
2007: L Thors; J Eriksson; C J Fowler
Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase-driven uptake.
British journal of pharmacology 2007;152(5):744-50.
2007: C J Fowler
The contribution of cyclooxygenase-2 to endocannabinoid metabolism and action.
British journal of pharmacology 2007;152(5):594-601.
2007: José Antonio Cisneros; Séverine Vandevoorde; Silvia Ortega-Gutiérrez; Clément Paris; Christopher J Fowler; María L López-Rodríguez
Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase.
Journal of medicinal chemistry 2007;50(20):5012-23.
2007: Christopher J Fowler
The pharmacology of the cannabinoid system--a question of efficacy and selectivity.
Molecular neurobiology 2007;36(1):15-25.
2007: A Lenman; C J Fowler
Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system.
British journal of pharmacology 2007;151(8):1343-51.
2007: Sandra Holt; Ben Paylor; Linda Boldrup; Kirsi Alajakku; Séverine Vandevoorde; Anna Sundström; Maria Teresa Cocco; Valentina Onnis; Christopher J Fowler
Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin.
European journal of pharmacology 2007;565(1-3):26-36.
2007: L Thors; K Alajakku; C J Fowler
The 'specific' tyrosine kinase inhibitor genistein inhibits the enzymic hydrolysis of anandamide: implications for anandamide uptake.
British journal of pharmacology 2007;150(7):951-60.
2007: S Vandevoorde; K-O Jonsson; G Labar; E Persson; D M Lambert; C J Fowler
Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro.
British journal of pharmacology 2007;150(2):186-91.
2006: Christopher J Fowler
The cannabinoid system and its pharmacological manipulation--a review, with emphasis upon the uptake and hydrolysis of anandamide.
Fundamental & clinical pharmacology 2006;20(6):549-62.
2006: Ben Paylor; Sandra Holt; Christopher J Fowler
The potency of the fatty acid amide hydrolase inhibitor URB597 is dependent upon the assay pH.
Pharmacological research : the official journal of the Italian Pharmacological Society 2006;54(6):481-5.
2006: Johan Brengdahl; Christopher J Fowler
A novel assay for monoacylglycerol hydrolysis suitable for high-throughput screening.
Analytical biochemistry 2006;359(1):40-4.
2006: Olov Nilsson; Christopher J Fowler; Stig O P Jacobsson
The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells.
European journal of pharmacology 2006;547(1-3):165-73.
2006: Eva De Lago; Sofia B Gustafsson; Javier Fernández-Ruiz; Jonas Nilsson; Stig O P Jacobsson; Christopher J Fowler
Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations.
Journal of neurochemistry 2006;99(2):677-88.
2006: L Thors; C J Fowler
Is there a temperature-dependent uptake of anandamide into cells?
British journal of pharmacology 2006;149(1):73-81.
2006: Kent-Olov Jonsson; Sandra Holt; Christopher J Fowler
The endocannabinoid system: current pharmacological research and therapeutic possibilities.
Basic & clinical pharmacology & toxicology 2006;98(2):124-34.
2006: Kent-Olov Jonsson; Emma Persson; Christopher J Fowler
The cannabinoid CB2 receptor selective agonist JWH133 reduces mast cell oedema in response to compound 48/80 in vivo but not the release of beta-hexosaminidase from skin slices in vitro.
Life sciences 2006;78(6):598-606.
2005: Christopher J Fowler
Pharmacological properties and therapeutic possibilities for drugs acting upon endocannabinoid receptors.
Current drug targets. CNS and neurological disorders 2005;4(6):685-96.
2005: Séverine Vandevoorde; Bijali Saha; Anu Mahadevan; Raj K Razdan; Roger G Pertwee; Billy R Martin; Christopher J Fowler
Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase.
Biochemical and biophysical research communications 2005;337(1):104-9.
2005: Sandra Holt; Francesca Comelli; Barbara Costa; Christopher J Fowler
Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors.
British journal of pharmacology 2005;146(3):467-76.
2005: Didier M Lambert; Christopher J Fowler
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.
Journal of medicinal chemistry 2005;48(16):5059-87.
2005: Séverine Vandevoorde; Christopher J Fowler
Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate.
British journal of pharmacology 2005;145(7):885-93.
2005: Christopher J Fowler; Sandra Holt; Olov Nilsson; Kent-Olov Jonsson; Gunnar Tiger; Stig O P Jacobsson
The endocannabinoid signaling system: pharmacological and therapeutic aspects.
Pharmacology, biochemistry, and behavior 2005;81(2):248-62.
2005: Christopher J Fowler; Gunnar Tiger
Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro.
Biochemical pharmacology 2005;69(8):1241-5.
2005: Anna Sandberg; Christopher J Fowler
Measurement of saturable and non-saturable components of anandamide uptake into P19 embryonic carcinoma cells in the presence of fatty acid-free bovine serum albumin.
Chemistry and physics of lipids 2005;134(2):131-9.
2004: Sandra Holt; David Rocksén; Anders Bucht; Gitte Petersen; Harald S Hansen; Marta Valenti; Vincenzo Di Marzo; Christopher J Fowler
Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase.
Life sciences 2004;76(4):461-72.
2004: Nazdar Ghafouri; Gunnar Tiger; Raj K Razdan; Anu Mahadevan; Roger G Pertwee; Billy R Martin; Christopher J Fowler
Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol.
British journal of pharmacology 2004;143(6):774-84.
2004: Linda Boldrup; Sandy J Wilson; Ann J Barbier; Christopher J Fowler
A simple stopped assay for fatty acid amide hydrolase avoiding the use of a chloroform extraction phase.
Journal of biochemical and biophysical methods 2004;60(2):171-7.
2004: Marie Karlsson; Charlotta Påhlsson; Christopher J Fowler
Reversible, temperature-dependent, and AM404-inhibitable adsorption of anandamide to cell culture wells as a confounding factor in release experiments.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;22(2-3):181-9.
2004: Christopher J Fowler; Gunnar Tiger; Alessia Ligresti; María L López-Rodríguez; Vincenzo Di Marzo
Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis--a difficult issue to handle.
European journal of pharmacology 2004;492(1):1-11.
2004: Christopher J Fowler
Possible involvement of the endocannabinoid system in the actions of three clinically used drugs.
Trends in pharmacological sciences 2004;25(2):59-61.
2004: Christopher J Fowler
Oleamide: a member of the endocannabinoid family?
British journal of pharmacology 2004;141(2):195-6.
2003: Olov Nilsson; Stig O P Jacobsson; Christopher J Fowler
Cannabinoid CB1 receptor activation does not prevent the toxicity of glutamate towards embryonic chick telencephalon primary cultures.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2003;136(3):245-51.
2003: C J Fowler; M Sandberg; G Tiger
Effects of water-soluble cigarette smoke extracts upon the release of beta-hexosaminidase from RBL-2H3 basophilic leukaemia cells in response to substance P, compound 48/80, concanavalin A and antigen stimulation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52(11):461-9.
2003: Séverine Vandevoorde; Kazuhito Tsuboi; Natsuo Ueda; Kent-Olov Jonsson; Christopher J Fowler; Didier M Lambert
Esters, retroesters, and a retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoylethanolamine-selective acid amidase.
Journal of medicinal chemistry 2003;46(21):4373-6.
2003: Christopher J Fowler; Kent-Olov Jonsson; Anna Andersson; Juha Juntunen; Tomi Järvinen; Séverine Vandevoorde; Didier M Lambert; Jeffrey C Jerman; Darren Smart
Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid.
Biochemical pharmacology 2003;66(5):757-67.
2003: Christopher J Fowler; Gunnar Tiger; María L López-Rodríguez; Alma Viso; Silvia Ortega-Gutiérrez; José A Ramos
Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin.
Journal of enzyme inhibition and medicinal chemistry 2003;18(3):225-31.
2003: María L López-Rodríguez; Alma Viso; Silvia Ortega-Gutiérrez; Christopher J Fowler; Gunnar Tiger; Eva de Lago; Javier Fernández-Ruiz; José A Ramos
Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.
Journal of medicinal chemistry 2003;46(8):1512-22.
2003: Séverine Vandevoorde; Kent-Olov Jonsson; Christopher J Fowler; Didier M Lambert
Modifications of the ethanolamine head in N-palmitoylethanolamine: synthesis and evaluation of new agents interfering with the metabolism of anandamide.
Journal of medicinal chemistry 2003;46(8):1440-8.
2003: María L López-Rodríguez; Alma Viso; Silvia Ortega-Gutiérrez; Christopher J Fowler; Gunnar Tiger; Eva de Lago; Javier Fernández-Ruiz; José A Ramos
Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors.
European journal of medicinal chemistry 2003;38(4):403-12.
2003: Kent-Olov Jonsson; Anna Andersson; Stig O P Jacobsson; Séverine Vandevoorde; Didier M Lambert; Christopher J Fowler
AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide.
Archives of toxicology 2003;77(4):201-7.
2003: Séverine Vandevoorde; Didier M Lambert; Darren Smart; Kent Olov Jonsson; Christopher J Fowler
N-Morpholino- and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without affecting fatty acid amidohydrolase activity.
Bioorganic & medicinal chemistry 2003;11(6):817-25.
2003: Sandra Holt; Christopher J Fowler
Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH.
Naunyn-Schmiedeberg's archives of pharmacology 2003;367(3):237-44.
2003: Christopher J Fowler; Sandra Holt; Gunnar Tiger
Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner.
Journal of enzyme inhibition and medicinal chemistry 2003;18(1):55-8.
2003: Christopher J Fowler
Plant-derived, synthetic and endogenous cannabinoids as neuroprotective agents. Non-psychoactive cannabinoids, 'entourage' compounds and inhibitors of N-acyl ethanolamine breakdown as therapeutic strategies to avoid pyschotropic effects.
Brain research. Brain research reviews 2003;41(1):26-43.
2002: Darren Smart; Kent-Olov Jonsson; Séverine Vandevoorde; Didier M Lambert; Christopher J Fowler
'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism.
British journal of pharmacology 2002;136(3):452-8.
2002: Didier M Lambert; Severine Vandevoorde; Kent-Olov Jonsson; Christopher J Fowler
The palmitoylethanolamide family: a new class of anti-inflammatory agents?
Current medicinal chemistry 2002;9(6):663-74.
2002: C J Fowler; S O P Jacobsson
Cellular transport of anandamide, 2-arachidonoylglycerol and palmitoylethanolamide--targets for drug development?
Prostaglandins, leukotrienes, and essential fatty acids 2002;66(2-3):193-200.
2001: S O Jacobsson; T Wallin; C J Fowler
Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors.
The Journal of pharmacology and experimental therapeutics 2001;299(3):951-9.
2001: C J Fowler; K O Jonsson; G Tiger
Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide.
Biochemical pharmacology 2001;62(5):517-26.
2001: K O Jonsson; S Vandevoorde; D M Lambert; G Tiger; C J Fowler
Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide.
British journal of pharmacology 2001;133(8):1263-75.
2001: M Granberg; C J Fowler; S O Jacobsson
Effects of the cannabimimetic fatty acid derivatives 2-arachidonoylglycerol, anandamide, palmitoylethanolamide and methanandamide upon IgE-dependent antigen-induced beta-hexosaminidase, serotonin and TNF alpha release from rat RBL-2H3 basophilic leukaemic cells.
Naunyn-Schmiedeberg's archives of pharmacology 2001;364(1):66-73.
2001: S Holt; J Nilsson; R Omeir; G Tiger; C J Fowler
Effects of pH on the inhibition of fatty acid amidohydrolase by ibuprofen.
British journal of pharmacology 2001;133(4):513-20.
2001: C J Fowler; O Nilsson; M Andersson; G Disney; S O Jacobsson; G Tiger
Pharmacological properties of cannabinoid receptors in the avian brain: similarity of rat and chicken cannabinoid1 receptor recognition sites and expression of cannabinoid2 receptor-like immunoreactivity in the embryonic chick brain.
Pharmacology & toxicology 2001;88(4):213-22.
2001: S O Jacobsson; C J Fowler
Characterization of palmitoylethanolamide transport in mouse Neuro-2a neuroblastoma and rat RBL-2H3 basophilic leukaemia cells: comparison with anandamide.
British journal of pharmacology 2001;132(8):1743-54.
2001: H L Hedin; L Nilsson; C J Fowler
Effects of staurosporine, U-73122, wortmannin, 4-hydroxynonenal and sodium azide upon the release of secreted beta-amyloid precursor protein from human platelets in response to thrombin stimulation.
Molecular and cellular biochemistry 2001;219(1-2):145-52.
2001: H L Hedin; S Eriksson; C J Fowler
Human platelet calcium mobilisation in response to beta-amyloid (25-35): buffer dependency and unchanged response in Alzheimer's disease.
Neurochemistry international 2001;38(2):145-51.
2000: S O Jacobsson; E Rongård; M Stridh; G Tiger; C J Fowler
Serum-dependent effects of tamoxifen and cannabinoids upon C6 glioma cell viability.
Biochemical pharmacology 2000;60(12):1807-13.
2000: P Englund; S O Jacobsson; C J Fowler
Investigation into the effects of amyloid (1-42) beta-peptide upon basal and antigen-stimulated hexosaminidase and serotonin release from rat RBL-2H3 basophilic leukemia cells.
Methods and findings in experimental and clinical pharmacology 2000;22(9):657-61.
2000: K O Jonsson; H L Hedin; C J Fowler
Investigation into the rapid effects of 17 beta-estradiol and neuroactive steroids upon beta-amyloid(25-35)-induced activation of phosphoinositide-specific phospholipase C in human platelets.
Methods and findings in experimental and clinical pharmacology 2000;22(8):615-20.
2000: C J Fowler; M Börjesson; G Tiger
Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase.
British journal of pharmacology 2000;131(3):498-504.
2000: H L Hedin; S Eriksson; C J Fowler
Rapid inhibition by sodium azide of the phosphoinositide-mediated calcium response to serotonin stimulation in human platelets: preservation in Alzheimer's disease.
Biochemical and biophysical research communications 2000;274(2):472-6.
2000: H L Hedin; C J Fowler
Effects of sodium azide on the secretion of soluble amyloid-beta precursor protein and the accumulation of beta-amyloid(1-40) in cultured chick neurons.
Neuroscience letters 2000;288(3):203-6.
2000: A Rönnbäck; C J Fowler
beta-Amyloid(25-35) inhibits the activity of inositol(1,4,5)-trisphosphate-5-phosphatase.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2000;7(2):90-4.
2000: M Andersson; S O Jacobsson; K O Jonsson; G Tiger; C J Fowler
Neurotoxicity of glutamate in chick telencephalon neurons: reduction of toxicity by preincubation with carbachol, but not by the endogenous fatty acid amides anandamide and palmitoylethanolamide.
Archives of toxicology 2000;74(3):161-4.
2000: G Tiger; A Stenström; C J Fowler
Pharmacological properties of rat brain fatty acid amidohydrolase in different subcellular fractions using palmitoylethanolamide as substrate.
Biochemical pharmacology 2000;59(6):647-53.
1999: C J Fowler; E Sjöberg; G Tiger
Serotonin stimulation of calcium mobilisation in human platelets: choice of units of measurement, effects of age and tobacco use, and correlation with serotonin2A receptor density.
Clinica chimica acta; international journal of clinical chemistry 1999;287(1-2):1-18.
1999: H L Hedin; C J Fowler
Further studies of the effects of diamide and hydrogen peroxide on calcium signaling in the human platelet.
Methods and findings in experimental and clinical pharmacology 1999;21(5):321-5.
1999: C J Fowler; V Vedin; E Sjöberg
Evidence for cooperative binding of (-)Isoproterenol to rat brain beta1-adrenergic receptors.
Biochemical and biophysical research communications 1999;257(2):629-34.
1999: C J Fowler; U Janson; R M Johnson; G Wahlström; A Stenström; K Norström; G Tiger
Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.
Archives of biochemistry and biophysics 1999;362(2):191-6.
1999: D Bergström; S O Jacobsson; C J Fowler
The effect of hydrogen peroxide upon beta-adrenoceptor density and function in C6 rat glioma cells.
Neurochemistry international 1999;34(1):63-70.
1999: S O Jacobsson; C J Fowler
Dopamine and glutamate neurotoxicity in cultured chick telencephali cells: effects of NMDA antagonists, antioxidants and MAO inhibitors.
Neurochemistry international 1999;34(1):49-62.
1998: H L Hedin; A Näsman; C J Fowler
The secretion of soluble amyloid beta precursor protein (A beta PPs) by chick neurons in serum-free primary culture is not regulated by protein kinase C.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1998;5(4):227-37.
1998: C J Fowler; G Tiger
Serotonin-stimulated calcium responses in human platelets: assay buffer dependency.
Cellular signalling 1998;10(8):561-8.
1998: C J Fowler; Y Ando; G Tiger
Comparison of the effects of hydrogen peroxide, 4-hydroxy-2-nonenal and beta-amyloid (25-35) upon calcium signalling.
Neurochemistry international 1998;33(2):161-72.
1998: C J Fowler; G Tiger
The sulphydryl oxidizing reagent diamide affects phosphoinositide-mediated signal transduction: implications for the pathogenesis of Alzheimer's disease.
Cellular signalling 1998;10(6):399-406.
1998: S O Jacobsson; H Hedin; A Sellström; C J Fowler
Characterization of the N-methyl-D-aspartate (NMDA) receptor in the embryonic chick brain.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(6):625-33.
1997: C J Fowler
The role of the phosphoinositide signalling system in the pathogenesis of sporadic Alzheimer's disease: a hypothesis.
Brain research. Brain research reviews 1997;25(3):373-80.
1997: C J Fowler; G Tiger; A Stenström
Ibuprofen inhibits rat brain deamidation of anandamide at pharmacologically relevant concentrations. Mode of inhibition and structure-activity relationship.
The Journal of pharmacology and experimental therapeutics 1997;283(2):729-34.
1997: C J Fowler; G Tiger
Calibration of Fura-2 signals introduces errors into measurement of thrombin-stimulated calcium mobilisation in human platelets.
Clinica chimica acta; international journal of clinical chemistry 1997;265(2):247-61.
1997: C J Fowler; A Stenström; G Tiger
Ibuprofen inhibits the metabolism of the endogenous cannabimimetic agent anandamide.
Pharmacology & toxicology 1997;80(2):103-7.
1996: R F Cowburn; C J Fowler; C O'Neill
Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(4):483-8.
1996: G Tiger; C J Fowler
Further validation of a simple biochemical method for evaluation of local anesthetic effects at sodium channels.
Methods and findings in experimental and clinical pharmacology 1996;18(7):431-5.
1996: C J Fowler; A Garlind; C O'Neill; R F Cowburn
Receptor-effector coupling dysfunctions in Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;786():294-304.
1996: R F Cowburn; C J Fowler; C O'Neill
Neurotransmitters, signal transduction and second-messengers in Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1996;165():25-32.
1995: G Tiger; D Lundin; C J Fowler
Veratrine-stimulated phosphoinositide breakdown as an assay for local anesthetic actions at Na+ channels.
Anesthesia and analgesia 1995;81(3):480-5.
1995: C J Fowler; R F Cowburn; A Garlind; B Winblad; C O'Neill
Disturbances in signal transduction mechanisms in Alzheimer's disease.
Molecular and cellular biochemistry 1995;149-150():287-92.
1995: A Garlind; R F Cowburn; C Forsell; R Ravid; B Winblad; C J Fowler
Diminished [3H]inositol(1,4,5)P3 but not [3H]inositol(1,3,4,5)P4 binding in Alzheimer's disease brain.
Brain research 1995;681(1-2):160-6.
1995: A Garlind; R F Cowburn; B Wiehager; R Ravid; B Winblad; C J Fowler
Preservation of kappa 1 opioid receptor recognition site density and regulation by G-proteins in the temporal cortex of patients with Alzheimer's disease.
Neuroscience letters 1995;185(2):131-4.
1995: A Garlind; R F Cowburn; C J Fowler
Characteristics of [3H]inositol(1,3,4,5)tetrakisphosphate recognition sites in human cerebellar membranes.
Journal of neural transmission. General section 1995;100(2):101-9.
1994: C O'Neill; B Wiehager; C J Fowler; R Ravid; B Winblad; R F Cowburn
Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain.
Brain research 1994;636(2):193-201.
1994: C O'Neill; C J Fowler; B Winblad; R F Cowburn
G-protein coupled signal transduction systems in the Alzheimer's disease brain.
Biochemical Society transactions 1994;22(1):167-71.
1994: A Garlind; R F Cowburn; C J Fowler
Characterization of [3H]inositol 1,4,5-trisphosphate binding sites in human temporal cortical and cerebellar membranes.
Neurochemistry international 1994;24(1):73-80.
1993: R F Cowburn; M Vestling; C J Fowler; R Ravid; B Winblad; C O'Neill
Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease.
Neuroscience letters 1993;155(2):163-6.
1992: R F Cowburn; C O'Neill; R Ravid; B Winblad; C J Fowler
Preservation of Gi-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease.
Neuroscience letters 1992;141(1):16-20.
1992: R F Cowburn; C O'Neill; R Ravid; I Alafuzoff; B Winblad; C J Fowler
Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease.
Journal of neurochemistry 1992;58(4):1409-19.
1992: C J Fowler; R F Cowburn; C O'Neill
Brain signal transduction disturbances in neurodegenerative disorders.
Cellular signalling 1992;4(1):1-9.
1992: C J Fowler; C O'Neill; B Winblad; R F Cowburn
Neurotransmitter, receptor and signal transduction disturbances in Alzheimer's disease.
Acta neurologica Scandinavica. Supplementum 1992;139():59-62.
1992: A Garlind; C J Fowler; I Alafuzoff; B Winblad; R F Cowburn
Neurotransmitter-mediated inhibition of post-mortem human brain adenylyl cyclase.
Journal of neural transmission. General section 1992;87(2):113-24.
1991: C O'Neill; R F Cowburn; B Wiehager; I Alafuzoff; B Winblad; C J Fowler
Preservation of 5-hydroxytryptamine1A receptor-G protein interactions in the cerebral cortex of patients with Alzheimer's disease.
Neuroscience letters 1991;133(1):15-9.
1991: C O'Neill; C J Fowler; B Wiehager; R F Cowburn; I Alafuzoff; B Winblad
Coupling of human brain cerebral cortical alpha 2-adrenoceptors to GTP-binding proteins in Alzheimer's disease.
Brain research 1991;563(1-2):39-43.
1991: L Bergström; A Garlind; L Nilsson; I Alafuzoff; C J Fowler; B Winblad; R F Cowburn
Regional distribution of somatostatin receptor binding and modulation of adenylyl cyclase activity in Alzheimer's disease brain.
Journal of the neurological sciences 1991;105(2):225-33.
1991: R F Cowburn; C J Fowler; A Garlind; I Alafuzoff; L Nilsson; B Winblad; L Bergström
Somatostatin receptors and the modulation of adenylyl cyclase activity in Alzheimer's disease.
Journal of neurology, neurosurgery, and psychiatry 1991;54(8):748-9.
1991: C O'Neill; C J Fowler; B Wiehager; I Alafuzoff; B Winblad
Assay of a phosphatidylinositol bisphosphate phospholipase C activity in postmortem human brain.
Brain research 1991;543(2):307-14.
1991: R F Cowburn; A Garlind; C O'Neill; I Alafuzoff; B Winblad; C J Fowler
Characterization and regional distribution of adenylyl cyclase activity from human brain.
Neurochemistry international 1991;18(3):389-98.
1991: G Tiger; C J Fowler
Modulation of carbachol-stimulated inositol phospholipid breakdown in rat cerebral cortical miniprisms by excitatory amino acids and by BAY K-8644 is dependent upon the assay calcium and potassium concentrations used.
Life sciences 1991;48(13):1283-91.
1991: G Tiger; C J Fowler
The Na+, K(+)-ATPase inhibitor ouabain and the Na+ ionophore monensin have opposite effects upon carbachol-stimulated inositol phospholipid breakdown in rat cerebral cortical miniprisms.
Cellular signalling 1991;3(3):209-13.
1990: G Tiger; P E Björklund; G Brännström; C J Fowler
Multiple actions of fluoride ions upon the phosphoinositide cycle in the rat brain.
Brain research 1990;537(1-2):93-101.
1990: G Tiger; P E Björklund; C J Fowler
Differential enhancement by potassium ions of M1-type and M2-type muscarinic receptor-mediated phosphoinositide breakdown in the rat brain.
Neuroscience letters 1990;115(2-3):243-7.
1990: C J Fowler; C O'Neill; A Garlind; R F Cowburn
Alzheimer's disease: is there a problem beyond recognition?
Trends in pharmacological sciences 1990;11(5):183-4.
1990: G Tiger; P E Björklund; R F Cowburn; A Garlind; C O'Neill; B Wiehager; C J Fowler
Effect of monovalent ions upon G proteins coupling muscarinic receptors to phosphoinositide hydrolysis in the rat cerebral cortex.
European journal of pharmacology 1990;188(1):51-62.
1989: G Tiger; P E Björklund; R F Cowburn; C J Fowler
Enhancement by potassium of carbachol-stimulated inositol phospholipid breakdown in rat cerebral cortical miniprisms: comparison with other depolarising agents.
Journal of neurochemistry 1989;52(6):1843-53.
1989: A Stenström; E Sundström; C J Fowler
Comparison of intra- and extrasynaptosomal monoamine oxidase-A and -B activities in the striatum and frontal cortex of two mice strains with different sensitivities to the neurotoxic actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Pharmacology & toxicology 1989;64(3):276-81.
1989: C J Fowler; C O'Neill; P Almqvist; S Nilsson; B Wiehager; B Winblad
Muscarinic receptors coupled to inositol phospholipid breakdown in human SH-SY5Y neuroblastoma cells: Effect of retinoic acid-induced differentiation.
Neurochemistry international 1989;15(1):73-9.
1989: C J Fowler; G Thorell; I Fagervall
Postmortem- and cryostability of the potassium-evoked release of [3H]5-hydroxytryptamine from rat cerebral cortical miniprisms.
Journal of neural transmission 1989;75(2):135-48.
1989: C O'Neill; C J Fowler; B Winblad
Alpha 1-adrenergic receptor binding sites in post-mortal human cerebral microvessel preparations: preservation in multi-infarct dementia and dementia of Alzheimer type.
Journal of neural transmission. Parkinson's disease and dementia section 1989;1(4):303-10.
1989: G Tiger; P E Björklund; C J Fowler
Stimulation of inositol phospholipid breakdown in pig brain miniprisms by carbachol and monoamines: effect of K+.
The International journal of biochemistry 1989;21(2):157-63.
1988: C O'Neill; C J Fowler; J O Marcusson; B Winblad
Adrenergic, serotoninergic, histaminergic, and imipramine binding sites in post-mortal human cerebral microvessel preparations.
Journal of neural transmission 1988;73(3):177-89.
1987: A K Mohammed; G Wahlström; G Tiger; P E Björklund; A Stenström; O Magnusson; T Archer; C J Fowler; A Nordberg
Impaired performance of rats in the Morris swim-maize test late in abstinence following long-term sodium barbital treatment.
Drug and alcohol dependence 1987;20(3):203-12.
1987: C J Fowler; J A Court; G Tiger; P E Björklund; J M Candy
Stimulation of inositol phospholipid breakdown in rat cortical and hippocampal miniprisms by noradrenaline, 5-hydroxytryptamine and carbachol: some methodological aspects.
Pharmacology & toxicology 1987;60(4):274-9.
1986: C J Fowler; O Magnusson; A K Mohammed; W Danysz; T Archer
The effect of selective noradrenergic lesions upon the stimulation by noradrenaline of inositol phospholipid breakdown in rat hippocampal miniprisms.
European journal of pharmacology 1986;123(3):401-7.