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Norma Fox

Research Profile

Chemicals & Drugs

Anatomy

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Mouse

Physiology

Disorders

Thrombocytopenia

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Phosphorylation

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Publications

TOP 3
Norma E Fox; Jihyang Lim; Rose Chen; Amy E Geddis
F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents.
Norma E Fox; Rose Chen; Ian Hitchcock; Jennifer Keates-Baleeiro; Haydar Frangoul; Amy E Geddis
Compound heterozygous c-Mpl mutations in a child with congenital amegakaryocytic thrombocytopenia: functional characterization and a review of the literature.
Takafumi Nakao; Amy E Geddis; Norma E Fox; Kenneth Kaushansky
PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1).

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All Publications

2010: Norma E Fox; Jihyang Lim; Rose Chen; Amy E Geddis
F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents.
Experimental hematology 2010;38(5):384-91.
2009: Norma E Fox; Rose Chen; Ian Hitchcock; Jennifer Keates-Baleeiro; Haydar Frangoul; Amy E Geddis
Compound heterozygous c-Mpl mutations in a child with congenital amegakaryocytic thrombocytopenia: functional characterization and a review of the literature.
Experimental hematology 2009;37(4):495-503.
2008: Takafumi Nakao; Amy E Geddis; Norma E Fox; Kenneth Kaushansky
PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1).
Cell cycle (Georgetown, Tex.) 2008;7(2):257-66.
2008: Ian S Hitchcock; Norma E Fox; Nicolas Prévost; Katherine Sear; Sanford J Shattil; Kenneth Kaushansky
Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout.
Blood 2008;111(2):596-604.
2007: Amy E Geddis; Norma E Fox; Eugene Tkachenko; Kenneth Kaushansky
Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression.
Cell cycle (Georgetown, Tex.) 2007;6(4):455-60.
2006: Supantitra Chanprasert; Amy E Geddis; Charlene Barroga; Norma E Fox; Kenneth Kaushansky
Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes.
Cellular signalling 2006;18(8):1212-8.
2006: Thomas R Coleman; Christof Westenfelder; Florian Tögel; Ying Yang; Zhuma Hu; Leanne Swenson; Henri G D Leuvenink; Rutger J Ploeg; Livius V d'Uscio; Zvonimir S Katusic; Pietro Ghezzi; Adriana Zanetti; Kenneth Kaushansky; Norma E Fox; Anthony Cerami; Michael Brines
Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5965-70.
2006: Amy E Geddis; Norma E Fox; Kenneth Kaushansky
The Mpl receptor expressed on endothelial cells does not contribute significantly to the regulation of circulating thrombopoietin levels.
Experimental hematology 2006;34(1):82-6.
2005: Norma E Fox; Kenneth Kaushansky
Engagement of integrin alpha4beta1 enhances thrombopoietin-induced megakaryopoiesis.
Experimental hematology 2005;33(1):94-9.
2001: Ponlapat Rojnuckarin; Y Miyakawa; Norma E Fox; Jessie Deou; Günter Daum; Kenneth Kaushansky
The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes.
The Journal of biological chemistry 2001;276(44):41014-22.
2001: Amy E Geddis; Norma E Fox; Kenneth Kaushansky
Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors.
The Journal of biological chemistry 2001;276(37):34473-9.
2001: C E Carow; Norma E Fox; Kenneth Kaushansky
Kinetics of endomitosis in primary murine megakaryocytes.
Journal of cellular physiology 2001;188(3):291-303.
2001: Q Wang; Norma E Fox; K Kaushansky
[Interferon-alpha directly inhibits thrombopoietin-induced megakaryocyte proliferation and differentiation].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 2001;22(6):296-9.
1997: Jonathan G Drachman; Diana F Sabath; Norma E Fox; Kenneth Kaushansky
Thrombopoietin signal transduction in purified murine megakaryocytes.
Blood 1997;89(2):483-92.