Brian Foxwell

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Chemicals & Drugs

Physiology

Anatomy

Disorders

Rheumatoid Arthritis

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Gasparini Chiara; Foxwell Brian M J; Feldmann Marc
RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.
Smith Andrew M; Rahman Farooq Z; Hayee Bu'Hussain; Graham Simon J; Marks Daniel J B; Sewell Gavin W; Palmer Christine D; Wilde Jonathan; Foxwell Brian M J; Gloger Israel S; Sweeting Trevor; Marsh Mark; Walker Ann P; Bloom Stuart L; Segal Anthony W
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease.
Thomson Scott J P; Goh Fui G; Banks Helen; Krausgruber Thomas; Kotenko Sergei V; Foxwell Brian M J; Udalova Irina A
The role of transposable elements in the regulation of IFN-lambda1 gene expression.

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All Publications

2009: Gasparini Chiara; Foxwell Brian M J; Feldmann Marc
RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.
European journal of immunology 2009;39(8):2215-23.
2009: Smith Andrew M; Rahman Farooq Z; Hayee Bu'Hussain; Graham Simon J; Marks Daniel J B; Sewell Gavin W; Palmer Christine D; Wilde Jonathan; Foxwell Brian M J; Gloger Israel S; Sweeting Trevor; Marsh Mark; Walker Ann P; Bloom Stuart L; Segal Anthony W
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease.
The Journal of experimental medicine 2009;206(9):1883-97.
2009: Thomson Scott J P; Goh Fui G; Banks Helen; Krausgruber Thomas; Kotenko Sergei V; Foxwell Brian M J; Udalova Irina A
The role of transposable elements in the regulation of IFN-lambda1 gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(28):11564-9.
2009: Midwood Kim; Sacre Sandra; Piccinini Anna M; Inglis Julia; Trebaul Annette; Chan Emma; Drexler Stefan; Sofat Nidhi; Kashiwagi Masahide; Orend Gertraud; Brennan Fionula; Foxwell Brian
Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.
Nature medicine 2009;15(7):774-80.
2009: Turner J J O; Smolinska M J; Sacre S M; Foxwell B M J
Induction of TLR tolerance in human macrophages by adiponectin: does LPS play a role?
Scandinavian journal of immunology 2009;69(4):329-36.
2009: Simmonds Rachel E; Lali Ferdinand V; Smallie Tim; Small Pamela L C; Foxwell Brian M
Mycolactone inhibits monocyte cytokine production by a posttranscriptional mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):2194-202.
2009: Page Theresa H; Smolinska Maria; Gillespie Justin; Urbaniak Anna M; Foxwell Brian M J
Tyrosine kinases and inflammatory signalling.
Current molecular medicine 2009;9(1):69-85.
2009: Sumariwalla P F; Palmer C D; Pickford L B; Feldmann M; Foxwell B M J; Brennan F M
Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.
Rheumatology (Oxford, England) 2009;48(1):32-8.
2008: Sacre Sandra M; Lo Alexandra; Gregory Bernard; Simmonds Rachel E; Williams Lynn; Feldmann Marc; Brennan Fionula M; Foxwell Brian M
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):8002-9.
2008: Unterberger Claudia; Staples Karl J; Smallie Timothy; Williams Lynn; Foxwell Brian; Schaefer Annette; Kempkes Bettina; Hofer T P J; Koeppel Max; Lohrum Marion; Stunnenberg Henk; Frankenberger Marion; Ziegler-Heitbrock Loems
Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene.
Molecular immunology 2008;45(11):3230-7.
2008: Palmer Christine D; Mutch Brenda E; Page Theresa H; Horwood Nicole J; Foxwell Brian M J
Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts.
Biochemical and biophysical research communications 2008;370(4):599-602.
2008: Williams Lynn M; Lali Ferdinand; Willetts Kate; Balague Cristina; Godessart Nuria; Brennan Fionula; Feldmann Marc; Foxwell Brian M J
Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.
Molecular immunology 2008;45(9):2446-54.
2008: Simmonds R E; Foxwell B M
Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation.
Rheumatology (Oxford, England) 2008;47(5):584-90.
2008: Palmer Christine D; Mutch Brenda E; Workman Sarita; McDaid John P; Horwood Nicole J; Foxwell Brian M J
Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity.
Blood 2008;111(4):1781-8.
2008: Smolinska Maria J; Horwood Nicole J; Page Theresa H; Smallie Tim; Foxwell Brian M J
Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages.
Molecular immunology 2008;45(4):990-1000.
2008: Drexler Stefan K; Kong Philip L; Wales Jeremy; Foxwell Brian M
Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis.
Arthritis research & therapy 2008;10(5):216.
2007: Wales Jeremy; Foxwell Brian; Feldmann Marc
Targeting intracellular signaling: a novel approach to vaccination.
Expert review of vaccines 2007;6(6):971-80.
2007: Wales J; Andreakos E; Feldmann M; Foxwell B
Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.
Biochemical Society transactions 2007;35(Pt 6):1501-3.
2007: El Kasmi Karim C; Smith Amber M; Williams Lynn; Neale Geoffrey; Panopoulos Athanasia D; Watowich Stephanie S; Häcker Hans; Foxwell Brian M J; Murray Peter J
Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7215-9.
2007: Sacre Sandra M; Drexler Stefan K; Andreakos Evangelos; Feldmann Marc; Brennan Fionula M; Foxwell Brian M J
Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii81-6.
2007: Lundberg Anna M; Drexler Stefan K; Monaco Claudia; Williams Lynn M; Sacre Sandra M; Feldmann Marc; Foxwell Brian M
Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.
Blood 2007;110(9):3245-52.
2007: Staples Karl J; Smallie Timothy; Williams Lynn M; Foey Andy; Burke Bernie; Foxwell Brian M J; Ziegler-Heitbrock Loems
IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4779-85.
2007: Sheryanna Abdulmunem; Bhangal Gurjeet; McDaid John; Smith Jennifer; Manning Anthony; Foxwell Brian M J; Feldmann Marc; Cook H Terence; Pusey Charles D; Tam Frederick W K
Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6.
Journal of the American Society of Nephrology : JASN 2007;18(4):1167-79.
2007: Williams Lynn M; Sarma Usha; Willets Kate; Smallie Tim; Brennan Fionula; Foxwell Brian M J
Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages.
The Journal of biological chemistry 2007;282(10):6965-75.
2007: Sacre Sandra M; Lundberg Anna M C; Andreakos Evangelos; Taylor Corinne; Feldmann Marc; Foxwell Brian M
Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2148-54.
2007: Sacre Sandra M; Andreakos Evangelos; Kiriakidis Serafim; Amjadi Parisa; Lundberg Anna; Giddins Grey; Feldmann Marc; Brennan Fionula; Foxwell Brian M
The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.
The American journal of pathology 2007;170(2):518-25.
2007: Davis Alison; Taylor Corinne; Willetts Kate; Smith Clive; Foxwell Brian M J
Adenoviral targeting of signal transduction pathways in synovial cell cultures.
Methods in molecular medicine 2007;136():395-419.
2006: Newton Sandra M; Smith Rebecca J; Wilkinson Katalin A; Nicol Mark P; Garton Natalie J; Staples Karl J; Stewart Graham R; Wain John R; Martineau Adrian R; Fandrich Sarah; Smallie Timothy; Foxwell Brian; Al-Obaidi Ahmed; Shafi Jamila; Rajakumar Kumar; Kampmann Beate; Andrew Peter W; Ziegler-Heitbrock Loems; Barer Michael R; Wilkinson Robert J
A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15594-8.
2006: Andreakos E; Williams R O; Wales J; Foxwell B M; Feldmann M
Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14459-64.
2006: Horwood Nicole J; Page Theresa H; McDaid John P; Palmer Christine D; Campbell Jamie; Mahon Tara; Brennan Fionula M; Webster David; Foxwell Brian M J
Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3635-41.
2006: Beech Jonathan T; Andreakos Evangelos; Ciesielski Cathleen J; Green Patricia; Foxwell Brian M J; Brennan Fionula M
T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFkappaB: implications for rheumatoid arthritis.
Arthritis research & therapy 2006;8(6):R168.
2005: Sacre Sandra M; Andreakos Evangelos; Taylor Peter; Feldmann Marc; Foxwell Brian M
Molecular therapeutic targets in rheumatoid arthritis.
Expert reviews in molecular medicine 2005;7(16):1-20.
2005: van Heel David A; Ghosh Subrata; Butler Matt; Hunt Karen; Foxwell Brian Michael J; Mengin-Lecreulx Dominique; Playford Raymond J
Synergistic enhancement of Toll-like receptor responses by NOD1 activation.
European journal of immunology 2005;35(8):2471-6.
2005: Tan Peng H; Sagoo Pervinder; Chan Cliburn; Yates John B; Campbell Jamie; Beutelspacher Sven C; Foxwell Brian M J; Lombardi Giovanna; George Andrew J T
Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):7633-44.
2005: van Heel David A; Ghosh Subrata; Butler Matt; Hunt Karen A; Lundberg Anna M C; Ahmad Tariq; McGovern Dermot P B; Onnie Clive; Negoro Kenichi; Goldthorpe Sue; Foxwell Brian M J; Mathew Christopher G; Forbes Alastair; Jewell Derek P; Playford Raymond J
Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.
Lancet 2005;365(9473):1794-6.
2005: Feldmann Marc; Brennan Fionula M; Foxwell Brian M J; Taylor Peter C; Williams Richard O; Maini R N
Anti-TNF therapy: where have we got to in 2005?
Journal of autoimmunity 2005;25 Suppl():26-8.
2005: Andreakos Evangelos; Sacre Sandra; Foxwell Brian M; Feldmann Marc
The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.
Frontiers in bioscience : a journal and virtual library 2005;10():2478-88.
2004: Campbell Jamie; Ciesielski Cathleen J; Hunt Abigail E; Horwood Nicole J; Beech Jonathan T; Hayes Louise A; Denys Agnes; Feldmann Marc; Brennan Fionula M; Foxwell Brian M J
A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6928-37.
2004: Andreakos Evangelos; Foxwell Brian; Feldmann Marc
Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
Immunological reviews 2004;202():250-65.
2004: Williams Lynn M; Ricchetti Giuseppe; Sarma Usha; Smallie Timothy; Foxwell Brian M J
Interleukin-10 suppression of myeloid cell activation--a continuing puzzle.
Immunology 2004;113(3):281-92.
2004: Ricchetti Giuseppe A; Williams Lynn M; Foxwell Brian M J
Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide.
Journal of leukocyte biology 2004;76(3):719-26.
2004: Monaco Claudia; Andreakos Evangelos; Kiriakidis Serafim; Mauri Claudia; Bicknell Colin; Foxwell Brian; Cheshire Nicholas; Paleolog Ewa; Feldmann Marc
Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5634-9.
2004: Lali Ferdinand V; Crawley James; McCulloch Derek A; Foxwell Brian M J
A late, prolonged activation of the phosphatidylinositol 3-kinase pathway is required for T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3527-34.
2004: Andreakos Evangelos; Sacre Sandra M; Smith Clive; Lundberg Anna; Kiriakidis Serafim; Stonehouse Tim; Monaco Claudia; Feldmann Marc; Foxwell Brian M
Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.
Blood 2004;103(6):2229-37.
2004: Williams Lynn; Bradley Laura; Smith Alexandra; Foxwell Brian
Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):567-76.
2004: Sacre Sandra M; Andreakos Evangelos; Feldmann Mark; Foxwell Brian M
Endotoxin signaling in human macrophages: signaling via an alternate mechanism.
Journal of endotoxin research 2004;10(6):445-52.
2003: Foxwell B; Andreakos E; Brennan F; Feldmann M; Smith C; Conron M
Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.
Annals of the rheumatic diseases 2003;62 Suppl 2():ii90-3.
2003: Yoshimura S; Bondeson J; Brennan F M; Foxwell B M J; Feldmann M
Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.
Scandinavian journal of immunology 2003;58(2):165-72.
2003: Andreakos Evangelos; Smith Clive; Kiriakidis Serafim; Monaco Claudia; de Martin Rainer; Brennan Fionula M; Paleolog Ewa; Feldmann Marc; Foxwell Brian M
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
Arthritis and rheumatism 2003;48(7):1901-12.
2003: Horwood Nicole J; Mahon Tara; McDaid John P; Campbell Jamie; Mano Hiroyuki; Brennan Fionula M; Webster David; Foxwell Brian M J
Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production.
The Journal of experimental medicine 2003;197(12):1603-11.
2003: Gasche Christoph; Grundtner Paul; Zwirn Petra; Reinisch Walter; Shaw Sarah H; Zdanov Alexander; Sarma Usha; Williams Lynn M; Foxwell Brian M; Gangl Alfred
Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5578-82.
2003: Calder V L; Bondeson J; Brennan F M; Foxwell B M J; Feldmann M
Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
Scandinavian journal of immunology 2003;57(3):261-70.
2003: Kiriakidis Serafim; Andreakos Evangelos; Monaco Claudia; Foxwell Brian; Feldmann Marc; Paleolog Ewa
VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
Journal of cell science 2003;116(Pt 4):665-74.
2003: Andreakos Evangelos; Smith Clive; Monaco Claudia; Brennan Fionula M; Foxwell Brian M; Feldmann Marc
Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.
Blood 2003;101(3):983-91.
2002: Feldmann M; Andreakos E; Smith C; Bondeson J; Yoshimura S; Kiriakidis S; Monaco C; Gasparini C; Sacre S; Lundberg A; Paleolog E; Horwood N J; Brennan F M; Foxwell B M J
Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Annals of the rheumatic diseases 2002;61 Suppl 2():ii13-8.
2002: Andreakos Evangelos T; Foxwell Brian M; Brennan Fionula M; Maini Ravinder N; Feldmann Marc
Cytokines and anti-cytokine biologicals in autoimmunity: present and future.
Cytokine & growth factor reviews 2002;13(4-5):299-313.
2002: Ciesielski Cathleen J; Andreakos Evangelos; Foxwell Brian M J; Feldmann Marc
TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
European journal of immunology 2002;32(7):2037-45.
2002: Hunt Abigail E; Williams Lynn M; Lali Ferdinand V; Foxwell Brian M J
IL-4 regulation of p38 MAPK signalling is dependent on cell type.
Cytokine 2002;18(6):295-303.
2002: Denys Agnes; Udalova Irina A; Smith Clive; Williams Lynn M; Ciesielski Cathleen J; Campbell Jamie; Andrews Caroline; Kwaitkowski Dominic; Foxwell Brian M J
Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):4837-45.
2002: Conron Matthew; Andreakos Evangelos; Pantelidis Panagiotis; Smith Clive; Beynon Huw L C; Dubois Roland M; Foxwell Brian M J
Nuclear factor-kappaB activation in alveolar macrophages requires IkappaB kinase-beta, but not nuclear factor-kappaB inducing kinase.
American journal of respiratory and critical care medicine 2002;165(7):996-1004.
2002: Pahlevan Ali A; Wright David J M; Bradley Laura; Smith Clive; Foxwell Brian M J
Potential of rifamides to inhibit TNF-induced NF-kappaB activation.
The Journal of antimicrobial chemotherapy 2002;49(3):531-4.
2002: Brennan Fionula M; Hayes Amanda L; Ciesielski Cathleen J; Green Patricia; Foxwell Brian M J; Feldmann Marc
Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
Arthritis and rheumatism 2002;46(1):31-41.
2002: Horwood Nicole J; Smith Clive; Andreakos Evangelos; Quattrocchi Emilia; Brennan Fionula M; Feldmann Marc; Foxwell Brian M J
High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.
Arthritis research 2002;4 Suppl 3():S215-25.
2002: Foey Andrew; Green Patricia; Foxwell Brian; Feldmann Marc; Brennan Fionula
Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.
Arthritis research 2002;4(1):64-70.
2001: Foxwell B M; Yoshimura S; Bondeson J; Brennan F M; Feldmann M
High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii13-7.
2001: Smith C; Andreakos E; Crawley J B; Brennan F M; Feldmann M; Foxwell B M
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5895-903.
2001: Conron M; Bondeson J; Pantelidis P; Beynon H L; Feldmann M; duBois R M; Foxwell B M
Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways.
American journal of respiratory cell and molecular biology 2001;25(2):141-9.
2001: Yoshimura S; Bondeson J; Brennan F M; Foxwell B M; Feldmann M
Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.
European journal of immunology 2001;31(6):1883-93.
2001: Feldmann M; Brennan F; Bondeson J; Paleolog E; Foxwell B; Maini R
Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities.
Transplantation proceedings 2001;33(3):2085-6.
2001: Isomäki P; Panesar M; Annenkov A; Clark J M; Foxwell B M; Chernajovsky Y; Cope A P
Prolonged exposure of T cells to TNF down-regulates TCR zeta and expression of the TCR/CD3 complex at the cell surface.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5495-507.
2001: Yoshimura S; Bondeson J; Foxwell B M; Brennan F M; Feldmann M
Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
International immunology 2001;13(5):675-83.
2001: Feldmann M; Maini R N; Bondeson J; Taylor P; Foxwell B M; Brennan F M
Cytokine blockade in rheumatoid arthritis.
Advances in experimental medicine and biology 2001;490():119-27.
2000: Udalova I A; Richardson A; Denys A; Smith C; Ackerman H; Foxwell B; Kwiatkowski D
Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.
Molecular and cellular biology 2000;20(24):9113-9.
2000: Foxwell B M; Bondeson J; Brennan F; Feldmann M
Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappaB in tumour necrosis factor production.
Annals of the rheumatic diseases 2000;59 Suppl 1():i54-9.
2000: Balkwill F; Foxwell B; Brennan F
TNF is here to stay!
Immunology today 2000;21(10):470-1.
2000: Bondeson J; Brennan F; Foxwell B; Feldmann M
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.
The Journal of rheumatology 2000;27(9):2078-89.
2000: Williams L; Lali F; Clarke C; Brennan F; Foxwell B
Interleukin 10 modulation of tumour necrosis factor receptors requires tyrosine kinases but not the PI 3-kinase/p70 S6 kinase pathway.
Cytokine 2000;12(7):934-43.
2000: Lali F V; Hunt A E; Turner S J; Foxwell B M
The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase.
The Journal of biological chemistry 2000;275(10):7395-402.
1999: Webb L M; Foxwell B M; Feldmann M
Putative role for interleukin-7 in the maintenance of the recirculating naive CD4+ T-cell pool.
Immunology 1999;98(3):400-5.
1999: Feldmann M; Bondeson J; Brennan F M; Foxwell B M; Maini R N
The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?
Annals of the rheumatic diseases 1999;58 Suppl 1():I27-31.
1999: Hayes A L; Smith C; Foxwell B M; Brennan F M
CD45-induced tumor necrosis factor alpha production in monocytes is phosphatidylinositol 3-kinase-dependent and nuclear factor-kappaB-independent.
The Journal of biological chemistry 1999;274(47):33455-61.
1999: Pahlevan A A; Wright D J; Andrews C; George K M; Small P L; Foxwell B M
The inhibitory action of Mycobacterium ulcerans soluble factor on monocyte/T cell cytokine production and NF-kappa B function.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3928-35.
1999: Bondeson J; Foxwell B; Brennan F; Feldmann M
Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5668-73.
1999: Bondeson J; Browne K A; Brennan F M; Foxwell B M; Feldmann M
Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2939-45.
1999: Hunt A E; Lali F V; Lord J D; Nelson B H; Miyazaki T; Tracey K J; Foxwell B M
Role of interleukin (IL)-2 receptor beta-chain subdomains and Shc in p38 mitogen-activated protein (MAP) kinase and p54 MAP kinase (stress-activated protein Kinase/c-Jun N-terminal kinase) activation. IL-2-driven proliferation is independent of p38 and p54 MAP kinase activation.
The Journal of biological chemistry 1999;274(11):7591-7.
1998: Foxwell B; Browne K; Bondeson J; Clarke C; de Martin R; Brennan F; Feldmann M
Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8211-5.
1998: Clarke C J; Hales A; Hunt A; Foxwell B M
IL-10-mediated suppression of TNF-alpha production is independent of its ability to inhibit NF kappa B activity.
European journal of immunology 1998;28(5):1719-26.
1998: Foey A D; Parry S L; Williams L M; Feldmann M; Foxwell B M; Brennan F M
Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):920-8.
1997: Cohen S B; Crawley J B; Kahan M C; Feldmann M; Foxwell B M
Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2.
Immunology 1997;92(1):1-5.
1997: Page T H; Lali F V; Groome N; Foxwell B M
Association of the common gamma-chain with the human IL-7 receptor is modulated by T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5727-35.
1997: Cohen S B; Parry S L; Feldmann M; Foxwell B
Autocrine and paracrine regulation of human T cell IL-10 production.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5596-602.
1997: Crawley J B; Rawlinson L; Lali F V; Page T H; Saklatvala J; Foxwell B M
T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation.
The Journal of biological chemistry 1997;272(23):15023-7.
1996: Crawley J B; Willcocks J; Foxwell B M
Interleukin-7 induces T cell proliferation in the absence of Erk/MAP kinase activity.
European journal of immunology 1996;26(11):2717-23.
1996: Crawley J B; Williams L M; Mander T; Brennan F M; Foxwell B M
Interleukin-10 stimulation of phosphatidylinositol 3-kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine.
The Journal of biological chemistry 1996;271(27):16357-62.
1995: Foxwell B M; Beadling C; Guschin D; Kerr I; Cantrell D
Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells.
European journal of immunology 1995;25(11):3041-6.
1995: Clarke C J; Taylor-Fishwick D A; Hales A; Chernajovsky Y; Sugamura K; Feldmann M; Foxwell B M
Interleukin-4 inhibits kappa light chain expression and NF kappa B activation but not I kappa B alpha degradation in 70Z/3 murine pre-B cells.
European journal of immunology 1995;25(10):2961-6.
1995: Page T H; Lali F V; Foxwell B M
Interleukin-7 activates p56lck and p59fyn, two tyrosine kinases associated with the p90 interleukin-7 receptor in primary human T cells.
European journal of immunology 1995;25(10):2956-60.
1993: Page T H; Willcocks J L; Taylor-Fishwick D A; Foxwell B M
Characterization of a novel high affinity human IL-7 receptor. Expression on T cells and association with IL-7 driven proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4753-63.
1993: Taylor-Fishwick D A; Kahan M; Hiestand P; Ritter M A; Foxwell B M
Evidence that rapamycin has differential effects of IL-4 function. Multiple IL-4 signaling pathways and implications for in vivo use.
Transplantation 1993;56(2):368-74.
1993: Cope A P; Gibbons D L; Aderka D; Foxwell B M; Wallach D; Maini R N; Feldmann M; Brennan F M
Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.
Cytokine 1993;5(3):205-12.
1993: Willcocks J L; Hales A; Page T H; Foxwell B M
The murine T cell line CT6 provides a novel bioassay for interleukin-7.
European journal of immunology 1993;23(3):716-20.
1993: Foxwell B M; Willcocks J L; Taylor-Fishwick D A; Kulig K; Ryffel B; Londei M
Inhibition of activation-induced changes in the structure of the T cell interleukin-7 receptor by cyclosporin A and FK506.
European journal of immunology 1993;23(1):85-9.
1993: Foxwell B; Barrett K
Introduction to cytokine receptors: structure and signal transduction.
International review of experimental pathology 1993;34 Pt B():105-21.
1992: Foxwell B M; Barrett K; Feldmann M
Cytokine receptors: structure and signal transduction.
Clinical and experimental immunology 1992;90(2):161-9.
1992: Ryffel B; Woerly G; Quesniaux V F; Husi H; Foxwell B M
Covalent binding of cyclosporine inhibits irreversibly T-lymphocyte activation.
Biochemical pharmacology 1992;43(5):953-60.
1992: Foxwell B M; Woerly G; Husi H; Mackie A; Quesniaux V F; Hiestand P C; Wenger R M; Ryffel B
Identification of several cyclosporine binding proteins in lymphoid and non-lymphoid cells in vivo.
Biochimica et biophysica acta 1992;1138(2):115-21.
1992: Foxwell B M; Taylor-Fishwick D A; Simon J L; Page T H; Londei M
Activation induced changes in expression and structure of the IL-7 receptor on human T cells.
International immunology 1992;4(2):277-82.
1991: Barrett K; Taylor-Fishwick D A; Cope A P; Kissonerghis A M; Gray P W; Feldmann M; Foxwell B M
Cloning, expression and cross-linking analysis of the murine p55 tumor necrosis factor receptor.
European journal of immunology 1991;21(7):1649-56.
1991: Ryffel B; Woerly G; Greiner B; Haendler B; Mihatsch M J; Foxwell B M
Distribution of the cyclosporine binding protein cyclophilin in human tissues.
Immunology 1991;72(3):399-404.
1991: Ryffel B; Woerly G; Rodriguez C; Foxwell B M
Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for cyclosporine.
Journal of receptor research 1991;11(1-4):675-86.
1990: Foxwell B M; Woerly G; Ryffel B
Inhibition of interleukin 4 receptor expression on human lymphoid cells by cyclosporin.
European journal of immunology 1990;20(5):1185-8.
1990: Foxwell B M; Ruffel B
The mechanisms of action of cyclosporine.
Cardiology clinics 1990;8(1):107-17.
1990: Foxwell B M; Simon J; Herrero J J; Taylor D; Woerly G; Cantrell D; Ryffel B
Anti-CD3 antibody-induced expression of both p55 and p75 chains of the high affinity interleukin-2 receptor on human T lymphocytes is inhibited by cyclosporin A.
Immunology 1990;69(1):104-9.
1989: Foxwell B M; Mackie A; Ling V; Ryffel B
Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein.
Molecular pharmacology 1989;36(4):543-6.
1989: Foxwell B M; Woerly G; Ryffel B
Identification of interleukin 4 receptor-associated proteins and expression of both high- and low-affinity binding on human lymphoid cells.
European journal of immunology 1989;19(9):1637-41.
1989: Foxwell B M; Wong W C; Borel J F; Ryffel B
A comparison of cyclosporine binding by cyclophilin and calmodulin.
Transplantation proceedings 1989;21(1 Pt 1):873-5.
1988: Foxwell B M; Taylor D; Greiner B; Mihatsch M J; Olivieri V; Ryffel B
Biotinylated recombinant interleukin-2. A tool for research on the interleukin-2 receptor.
Journal of immunological methods 1988;113(2):221-9.
1988: Ryffel B; Foxwell B M; Gee A; Greiner B; Woerly G; Mihatsch M J
Cyclosporine--relationship of side effects to mode of action.
Transplantation 1988;46(2 Suppl):90S-96S.
1988: Foxwell B M; Hiestand P C; Wenger R; Ryffel B
A comparison of cyclosporine binding by cyclophilin and calmodulin and the identification of a novel 45 KD cyclosporine-binding phosphoprotein in Jurkat cells.
Transplantation 1988;46(2 Suppl):35S-40S.
1988: Ryffel B; Foxwell B M; Mihatsch M J; Donatsch P; Maurer G
Biologic significance of cyclosporine metabolites.
Transplantation proceedings 1988;20(2 Suppl 2):575-84.
1988: Foxwell B M; Frazer G; Winters M; Hiestand P; Wenger R; Ryffel B
Identification of cyclophilin as the erythrocyte ciclosporin-binding protein.
Biochimica et biophysica acta 1988;938(3):447-55.
1986: Ryffel B; Hiestand P; Foxwell B; Donatsch P; Boelsterli H J; Maurer G; Mihatsch M J
Nephrotoxic and immunosuppressive potentials of cyclosporine metabolites in rats.
Transplantation proceedings 1986;18(6 Suppl 5):41-5.

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