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Harry Fozzard

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TOP 3
Gregory M Lipkind; Harry A Fozzard; Dorothy A Hanck
A molecular model of the inner pore of the Ca channel in its open state.
Harry A Fozzard; Michael F Sheets; Dorothy A Hanck
The sodium channel as a target for local anesthetic drugs.
Touran Zarrabi; Rene Cervenka; Walter Sandtner; Peter Lukacs; Xaver Koenig; Karlheinz Hilber; Markus Mille; Gregory M Lipkind; Harry A Fozzard; Hannes Todt
A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.

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All Publications

2011: Gregory M Lipkind; Harry A Fozzard; Dorothy A Hanck
A molecular model of the inner pore of the Ca channel in its open state.
Channels (Austin, Tex.) 2011;5(6):482-8.
2011: Harry A Fozzard; Michael F Sheets; Dorothy A Hanck
The sodium channel as a target for local anesthetic drugs.
Frontiers in pharmacology 2011;2():68.
2010: Touran Zarrabi; Rene Cervenka; Walter Sandtner; Peter Lukacs; Xaver Koenig; Karlheinz Hilber; Markus Mille; Gregory M Lipkind; Harry A Fozzard; Hannes Todt
A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.
The Journal of biological chemistry 2010;285(50):39458-70.
2010: Gregory M Lipkind; Harry A Fozzard
Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore.
Molecular pharmacology 2010;78(4):631-8.
2010: Michael F Sheets; Harry A Fozzard; Gregory M Lipkind; Dorothy A Hanck
Sodium channel molecular conformations and antiarrhythmic drug affinity.
Trends in cardiovascular medicine 2010;20(1):16-21.
2010: Harry A Fozzard; Gregory M Lipkind
The tetrodotoxin binding site is within the outer vestibule of the sodium channel.
Marine drugs 2010;8(2):219-34.
2009: Dorothy A Hanck; Elena Nikitina; Megan M McNulty; Harry A Fozzard; Gregory M Lipkind; Michael F Sheets
Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.
Circulation research 2009;105(5):492-9.
2008: Harry A Fozzard
Increased sensitivity to local anesthetic drugs: bedside to bench.
Circulation research 2008;103(4):325-7.
2008: Gregory M Lipkind; Harry A Fozzard
Voltage-gated Na channel selectivity: the role of the conserved domain III lysine residue.
The Journal of general physiology 2008;131(6):523-9.
2008: Manda Clair Jost; David M Hillis; Ying Lu; John W Kyle; Harry A Fozzard; Harold H Zakon
Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.
Molecular biology and evolution 2008;25(6):1016-24.
2007: Julia Szendroedi; Walter Sandtner; Touran Zarrabi; Eva Zebedin; Karlheinz Hilber; Samuel C Dudley; Harry A Fozzard; Hannes Todt
Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?
Biophysical journal 2007;93(12):4209-24.
2007: Megan M McNulty; Gabrielle B Edgerton; Ravi D Shah; Dorothy A Hanck; Harry A Fozzard; Gregory M Lipkind
Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.
The Journal of physiology 2007;581(Pt 2):741-55.
2006: A Khan; John W Kyle; Dorothy A Hanck; Gregory M Lipkind; Harry A Fozzard
Isoform-dependent interaction of voltage-gated sodium channels with protons.
The Journal of physiology 2006;576(Pt 2):493-501.
2005: Gregory M Lipkind; Harry A Fozzard
Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels.
Molecular pharmacology 2005;68(6):1611-22.
2005: Karlheinz Hilber; Walter Sandtner; Touran Zarrabi; Eva Zebedin; Oliver Kudlacek; Harry A Fozzard; Hannes Todt
Selectivity filter residues contribute unequally to pore stabilization in voltage-gated sodium channels.
Biochemistry 2005;44(42):13874-82.
2005: Harry A Fozzard; P J Lee; Gregory M Lipkind
Mechanism of local anesthetic drug action on voltage-gated sodium channels.
Current pharmaceutical design 2005;11(21):2671-86.
2004: Akihiko Sunami; Arlene Tracey; Ian W Glaaser; Gregory M Lipkind; Dorothy A Hanck; Harry A Fozzard
Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.
The Journal of physiology 2004;561(Pt 2):403-13.
2004: Walter Sandtner; Julia Szendroedi; Touran Zarrabi; Eva Zebedin; Karlheinz Hilber; Ian W Glaaser; Harry A Fozzard; Samuel C Dudley; Hannes Todt
Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.
Molecular pharmacology 2004;66(3):648-57.
2003: Gregory M Lipkind; Harry A Fozzard
Molecular modeling of interactions of dihydropyridines and phenylalkylamines with the inner pore of the L-type Ca2+ channel.
Molecular pharmacology 2003;63(3):499-511.
2003: Harry A Fozzard
Fifty years of cardiovascular science together.
Circulation research 2003;92(1):4-5.
2002: Karlheinz Hilber; Walter Sandtner; Oliver Kudlacek; Blanca Schreiner; Ian W Glaaser; Wolfgang Schütz; Harry A Fozzard; Samuel C Dudley; Hannes Todt
Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?
The Journal of biological chemistry 2002;277(40):37105-15.
2002: A Khan; L Romantseva; A Lam; Gregory M Lipkind; Harry A Fozzard
Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block.
The Journal of physiology 2002;543(Pt 1):71-84.
2002: Harry A Fozzard
Cardiac sodium and calcium channels: a history of excitatory currents.
Cardiovascular research 2002;55(1):1-8.
2002: Harry A Fozzard; John W Kyle
Do defects in ion channel glycosylation set the stage for lethal cardiac arrhythmias?
Science's STKE : signal transduction knowledge environment 2002;2002(130):pe19.
2002: Kwokyin Hui; Gregory M Lipkind; Harry A Fozzard; Robert J French
Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin.
The Journal of general physiology 2002;119(1):45-54.
2001: P J Lee; Akihiko Sunami; Harry A Fozzard
Cardiac-specific external paths for lidocaine, defined by isoform-specific residues, accelerate recovery from use-dependent block.
Circulation research 2001;89(11):1014-21.
2001: Karlheinz Hilber; Walter Sandtner; Oliver Kudlacek; Ian W Glaaser; Eva Weisz; John W Kyle; Robert J French; Harry A Fozzard; Samuel C Dudley; Hannes Todt
The selectivity filter of the voltage-gated sodium channel is involved in channel activation.
The Journal of biological chemistry 2001;276(30):27831-9.
2001: Gregory M Lipkind; Harry A Fozzard
Modeling of the outer vestibule and selectivity filter of the L-type Ca2+ channel.
Biochemistry 2001;40(23):6786-94.
2001: Akihiko Sunami; Ian W Glaaser; Harry A Fozzard
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.
Molecular pharmacology 2001;59(4):684-91.
2001: JL Penzotti; Gregory M Lipkind; Harry A Fozzard; Samuel C Dudley
Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis.
Biophysical journal 2001;80(2):698-706.
2000: Samuel C Dudley; N Chang; J Hall; Gregory M Lipkind; Harry A Fozzard; Robert J French
mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.
The Journal of general physiology 2000;116(5):679-90.
2000: Gregory M Lipkind; Harry A Fozzard
KcsA crystal structure as framework for a molecular model of the Na(+) channel pore.
Biochemistry 2000;39(28):8161-70.
2000: Harry A Fozzard
Channel-specific therapy of cardiac arrhythmias in our time?
Journal of cardiovascular electrophysiology 2000;11(3):369-70.
2000: Akihiko Sunami; Ian W Glaaser; Harry A Fozzard
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2326-31.
1999: Hannes Todt; Samuel C Dudley; John W Kyle; Robert J French; Harry A Fozzard
Ultra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibule.
Biophysical journal 1999;76(3):1335-45.
1998: JL Penzotti; Harry A Fozzard; Gregory M Lipkind; Samuel C Dudley
Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.
Biophysical journal 1998;75(6):2647-57.
1998: N S Chang; Robert J French; Gregory M Lipkind; Harry A Fozzard; Samuel C Dudley
Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis.
Biochemistry 1998;37(13):4407-19.
1997: Akihiko Sunami; Samuel C Dudley; Harry A Fozzard
Sodium channel selectivity filter regulates antiarrhythmic drug binding.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):14126-31.
1997: Gregory M Lipkind; Harry A Fozzard
A model of scorpion toxin binding to voltage-gated K+ channels.
The Journal of membrane biology 1997;158(3):187-96.
1996: Harry A Fozzard; Gregory M Lipkind
The guanidinium toxin binding site on the sodium channel.
Japanese heart journal 1996;37(5):683-92.
1996: S Y Chang; Satin Jonathan; Harry A Fozzard
Modal behavior of the mu 1 Na+ channel and effects of coexpression of the beta 1-subunit.
Biophysical journal 1996;70(6):2581-92.
1995: Clive M Baumgarten; Samuel C Dudley; R B Rogart; Harry A Fozzard
Unitary conductance of Na+ channel isoforms in cardiac and NB2a neuroblastoma cells.
The American journal of physiology 1995;269(6 Pt 1):C1356-63.
1995: Samuel C Dudley; H Todt; Gregory M Lipkind; Harry A Fozzard
A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule.
Biophysical journal 1995;69(5):1657-65.
1995: Gregory M Lipkind; Dorothy A Hanck; Harry A Fozzard
A structural motif for the voltage-gated potassium channel pore.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9215-9.
1995: Harry A Fozzard; Gregory M Lipkind
Ion channels and pumps in cardiac function.
Advances in experimental medicine and biology 1995;382():3-10.
1994: Satin Jonathan; J T Limberis; J W Kyle; R B Rogart; Harry A Fozzard
The saxitoxin/tetrodotoxin binding site on cloned rat brain IIa Na channels is in the transmembrane electric field.
Biophysical journal 1994;67(3):1007-14.
1994: Satin Jonathan; J W Kyle; Z Fan; R Rogart; Harry A Fozzard; Jonathan C Makielski
Post-repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids.
Biophysical journal 1994;66(5):1353-63.
1994: Gregory M Lipkind; Harry A Fozzard
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel.
Biophysical journal 1994;66(1):1-13.
1993: K Ono; Harry A Fozzard
Two phosphatase sites on the Ca2+ channel affecting different kinetic functions.
The Journal of physiology 1993;470():73-84.
1993: K Ono; Harry A Fozzard; Dorothy A Hanck
Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics.
Circulation research 1993;72(4):807-15.
1993: Donald D Doyle; Y Guo; S L Lustig; Satin Jonathan; R B Rogart; Harry A Fozzard
Divalent cation competition with [3H]saxitoxin binding to tetrodotoxin-resistant and -sensitive sodium channels. A two-site structural model of ion/toxin interaction.
The Journal of general physiology 1993;101(2):153-82.
1992: Satin Jonathan; J W Kyle; M Chen; R B Rogart; Harry A Fozzard
The cloned cardiac Na channel alpha-subunit expressed in Xenopus oocytes show gating and blocking properties of native channels.
The Journal of membrane biology 1992;130(1):11-22.
1992: K Ono; Harry A Fozzard
Phosphorylation restores activity of L-type calcium channels after rundown in inside-out patches from rabbit cardiac cells.
The Journal of physiology 1992;454():673-88.
1992: Satin Jonathan; J W Kyle; M Chen; P Bell; Leanne L Cribbs; Harry A Fozzard; R B Rogart
A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties.
Science (New York, N.Y.) 1992;256(5060):1202-5.
1992: N el-Sherif; Harry A Fozzard; Dorothy A Hanck
Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII.
Circulation research 1992;70(2):285-301.
1991: Clive M Baumgarten; Jonathan C Makielski; Harry A Fozzard
External site for local anesthetic block of cardiac Na+ channels.
Journal of molecular and cellular cardiology 1991;23 Suppl 1():85-93.
1991: Harry A Fozzard
Excitation-contraction coupling in the heart.
Advances in experimental medicine and biology 1991;308():135-42.
1990: Leanne L Cribbs; Satin Jonathan; Harry A Fozzard; R B Rogart
Functional expression of the rat heart I Na+ channel isoform. Demonstration of properties characteristic of native cardiac Na+ channels.
FEBS letters 1990;275(1-2):195-200.
1990: Dorothy A Hanck; Michael F Sheets; Harry A Fozzard
Gating currents associated with Na channels in canine cardiac Purkinje cells.
The Journal of general physiology 1990;95(3):439-57.
1990: B E Scanley; Dorothy A Hanck; T Chay; Harry A Fozzard
Kinetic analysis of single sodium channels from canine cardiac Purkinje cells.
The Journal of general physiology 1990;95(3):411-37.
1989: Y Hirano; Harry A Fozzard; Craig T January
Inactivation properties of T-type calcium current in canine cardiac Purkinje cells.
Biophysical journal 1989;56(5):1007-16.
1989: L A Alpert; Harry A Fozzard; Dorothy A Hanck; Jonathan C Makielski
Is there a second external lidocaine binding site on mammalian cardiac cells?
The American journal of physiology 1989;257(1 Pt 2):H79-84.
1989: Y Hirano; Harry A Fozzard; Craig T January
Characteristics of L- and T-type Ca2+ currents in canine cardiac Purkinje cells.
The American journal of physiology 1989;256(5 Pt 2):H1478-92.
1989: Albertas I Undrovinas; N A Burnashev; V V Nesterenko; Jonathan C Makielski; I A Fleidervish; Harry A Fozzard; L V Rosenshtraukh
Single channel sodium current in rat cardiomyocytes: use-dependent block by ethacizin.
The Journal of pharmacology and experimental therapeutics 1989;248(3):1138-45.
1989: T Nakayama; C Palfrey; Harry A Fozzard
Modulation of the cardiac transient outward current by catecholamines.
Journal of molecular and cellular cardiology 1989;21 Suppl 1():109-18.
1988: Craig T January; Harry A Fozzard
Delayed afterdepolarizations in heart muscle: mechanisms and relevance.
Pharmacological reviews 1988;40(3):219-27.
1988: Michael F Sheets; Dorothy A Hanck; Harry A Fozzard
Nonlinear relation between Vmax and INa in canine cardiac Purkinje cells.
Circulation research 1988;63(2):386-98.
1988: Jonathan C Makielski; Albertas I Undrovinas; Dorothy A Hanck; Michael F Sheets; V V Nesterenko; L A Alpert; L V Rosenshtraukh; Harry A Fozzard
Use-dependent block of sodium current by ethmozin in voltage-clamped internally perfused canine cardiac Purkinje cells.
Journal of molecular and cellular cardiology 1988;20(3):255-65.
1988: Ole M Sejersted; J A Wasserstrom; Harry A Fozzard
Na,K pump stimulation by intracellular Na in isolated, intact sheep cardiac Purkinje fibers.
The Journal of general physiology 1988;91(3):445-66.
1988: T Nakayama; Harry A Fozzard
Adrenergic modulation of the transient outward current in isolated canine Purkinje cells.
Circulation research 1988;62(1):162-72.
1987: Harry A Fozzard; Dorothy A Hanck; Jonathan C Makielski; B E Scanley; Michael F Sheets
Sodium channels in cardiac Purkinje cells.
Experientia 1987;43(11-12):1162-8.
1987: scott schell; Deborah J Nelson; Harry A Fozzard; F W Fitch
The inhibitory effects of K+ channel-blocking agents on T lymphocyte proliferation and lymphokine production are "nonspecific".
Journal of immunology (Baltimore, Md. : 1950) 1987;139(10):3224-30.
1987: B E Scanley; Harry A Fozzard
Low conductance sodium channels in canine cardiac Purkinje cells.
Biophysical journal 1987;52(3):489-95.
1987: Jonathan C Makielski; Michael F Sheets; Dorothy A Hanck; Craig T January; Harry A Fozzard
Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells.
Biophysical journal 1987;52(1):1-11.
1987: Michael F Sheets; B E Scanley; Dorothy A Hanck; Jonathan C Makielski; Harry A Fozzard
Open sodium channel properties of single canine cardiac Purkinje cells.
Biophysical journal 1987;52(1):13-22.
1987: D M Brill; Harry A Fozzard; Jonathan C Makielski; J A Wasserstrom
Effect of prolonged depolarizations on twitch tension and intracellular sodium activity in sheep cardiac Purkinje fibres.
The Journal of physiology 1987;384():355-75.
1986: R A Chapman; Harry A Fozzard; I R Friedlander; Craig T January
Effects of Ca2+/Mg2+ removal on aiNa, aiK, and tension in cardiac Purkinje fibers.
The American journal of physiology 1986;251(6 Pt 1):C920-7.
1986: Harry A Fozzard; I R Friedlander; Dorothy A Hanck; Craig T January; Jonathan C Makielski; Michael F Sheets
Sodium currents in single cardiac Purkinje cells.
Journal of the American College of Cardiology 1986;8(1 Suppl A):79A-85A.
1985: Harry A Fozzard; Craig T January; Jonathan C Makielski
New studies of the excitatory sodium currents in heart muscle.
Circulation research 1985;56(4):475-85.
1983: Michael F Sheets; Craig T January; Harry A Fozzard
Isolation and characterization of single canine cardiac purkinje cells.
Circulation research 1983;53(4):544-8.