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Mario Fraga

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TOP 3
Covadonga Huidobro; Agustin F Fernandez; Mario F Fraga
Aging epigenetics: Causes and consequences.
Covadonga Huidobro; Agustin F Fernandez; Mario F Fraga
The role of genetics in the establishment and maintenance of the epigenome.
Ramon M Rodriguez; Rubén Salvanés; Miguel Alcoceba Sánchez; Beatriz Suarez-Alvarez; Enrique Colado; Marcos González Díaz; Agustin F Fernandez; Mario F Fraga; Pablo Martínez-Camblor; Manuel Muro; Carlos Lopez-Larrea
DNA methylation dynamics in blood after hematopoietic cell transplant.

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All Publications

2013: Covadonga Huidobro; Agustin F Fernandez; Mario F Fraga
Aging epigenetics: Causes and consequences.
Molecular aspects of medicine 2013;34(4):765-81.
2013: Covadonga Huidobro; Agustin F Fernandez; Mario F Fraga
The role of genetics in the establishment and maintenance of the epigenome.
Cellular and molecular life sciences : CMLS 2013;70(9):1543-73.
2013: Ramon M Rodriguez; Rubén Salvanés; Miguel Alcoceba Sánchez; Beatriz Suarez-Alvarez; Enrique Colado; Marcos González Díaz; Agustin F Fernandez; Mario F Fraga; Pablo Martínez-Camblor; Manuel Muro; Carlos Lopez-Larrea
DNA methylation dynamics in blood after hematopoietic cell transplant.
PloS one 2013;8(2):e56931.
2013: Rocio G Urdinguio; Teresa Bernal; Felix Bonilla; Santiago Cal; Gemma Dominguez; Agustin F Fernandez; Cecilia Ferrero; Covadonga Huidobro; Carlos Lopez-Otin; Pablo Martinez-Camblor; Xavier Matias-Guiu; Angela Moncada-Pazos; Alvaro J Obaya; Adolfo Parra-Blanco; Luis Rodrigo; Ramon M Rodriguez; Maria Santacana; Beatriz Soldevilla; Mario F Fraga
Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors.
Cancer research 2013;73(1):395-405.
2012: Agustin F Fernandez; Covadonga Huidobro; Mario F Fraga
De novo DNA methyltransferases: oncogenes, tumor suppressors, or both?
Trends in genetics : TIG 2012;28(10):474-9.
2012: Sofía Tirados Menéndez; Luis A Pardo; Juan P Rodrigo; Carlos Suárez; Rocío G Urdinguio; María Angeles Villaronga; Cristina G Viloria; Saúl Alvarez-Teijeiro; Mario F Fraga; Darío García-Carracedo; Juana M García Pedrero
Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implications.
Journal of molecular medicine (Berlin, Germany) 2012;90(10):1173-84.
2012: Covadonga Huidobro; Cristina Mangas; Pablo Martínez-Camblor; Alvaro J Obaya; Adolfo Parra-Blanco; Luis Rodrigo; Ramón María Rodríguez; Laura Suárez-Fernández; Rocío G Urdinguio; AURORA ASTUDILLO; Esteban Ballestar; Vincenzo Calvanese; Agustín F Fernández; Cecilia Ferrero; Henar Hernando; Mario F Fraga
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
European journal of cancer (Oxford, England : 1990) 2012;48(14):2270-81.
2012: Holger Heyn; Isabel Iglesias-Platas; Ning Li; Sebastian Moran; David G Pisano; Annibale A Puca; Miguel A Pujana; Jose V Sanchez-Mut; Sergi Sayols; Jordi Serra-Musach; Fernando Setien; Alfonso Valencia; Jun Wang; Agustin F Fernandez; Humberto J Ferreira; Francesc Formiga; Mario F Fraga; Antonio Gomez; Ivo G Gut; Simon C Heath; F Javier Carmona; Javier Diez; Manel Esteller
Distinct DNA methylomes of newborns and centenarians.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10522-7.
2012: Rasmus Ribel-Madsen; Allan Vaag; Birgitte F Vind; Henning Beck-Nielsen; Jette Bork-Jensen; Vincenzo Calvanese; Manel Esteller; Agustin F Fernandez; Mario F Fraga; Martin Friedrichsen; Kurt Højlund; Stine Jacobsen; Ester Lara; Pernille Poulsen
Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes.
PloS one 2012;7(12):e51302.
2012: Vincenzo Calvanese; Mario F Fraga
Epigenetics of embryonic stem cells.
Advances in experimental medicine and biology 2012;741():231-53.
2012: Vincenzo Calvanese; Ester Lara; Mario F Fraga
Epigenetic code and self-identity.
Advances in experimental medicine and biology 2012;738():236-55.
2012: Vincenzo Calvanese; Ana Clara Carrera; Agustín F Fernández; Cecilia Ferrero; Yassen Assenov; Christoph Bock; Clara Bueno; Carlos Lopez-Larrea; Cristina Mangas; Pablo Martínez-Camblor; Pablo Menendez; Rosa Montes; Vicente Pérez-García; Verónica Ramos-Mejía; Beatriz Suárez-Alvarez; Rocío G Urdinguio; Mario F Fraga
A promoter DNA demethylation landscape of human hematopoietic differentiation.
Nucleic acids research 2012;40(1):116-31.
2011: Agustín F Fernández; Mario F Fraga
The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan.
Epigenetics : official journal of the DNA Methylation Society 2011;6(7):870-4.
2011: Sandra Rodriguez-Rodero; Edelmiro Menéndez Torre; Vincenzo Calvanese; Agustín F Fernández; Juan Luis Fernandez-Morera; Mario F Fraga
Aging genetics and aging.
Aging and disease 2011;2(3):186-95.
2010: Fernando G Osorio; Ignacio Varela; Ester Lara; Xose S Puente; Jesús Espada; Raffaella Santoro; José M P Freije; Mario F Fraga; Carlos López-Otín
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.
Aging cell 2010;9(6):947-57.
2010: Ramon M Rodriguez; Mario F Fraga
Aging and cancer: are sirtuins the link?
Future oncology (London, England) 2010;6(6):905-15.
2010: dante rotili; Domenico Tarantino; Vincenzo Carafa; Ester Lara; Sarah Meade; Giorgia Botta; Angela Nebbioso; Jörg Schemies; Manfred Jung; Aleksey G Kazantsev; Manel Esteller; Mario F Fraga; Lucia Altucci; Antonello Mai
Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors.
ChemMedChem 2010;5(5):674-7.
2010: Biola M Javierre; Agustin F Fernandez; Julia Richter; Fatima Al-Shahrour; J Ignacio Martin-Subero; Javier Rodriguez-Ubreva; Maria Berdasco; Mario F Fraga; Terrance P O'Hanlon; Lisa G Rider; Filipe V Jacinto; F Javier Lopez-Longo; Joaquin Dopazo; Marta Forn; Miguel A Peinado; Luis Carreño; Amr H Sawalha; John B Harley; Reiner Siebert; Manel Esteller; Frederick W Miller; Esteban Ballestar
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus.
Genome research 2010;20(2):170-9.
2010: Ester Lara; Vincenzo Calvanese; Covadonga Huidobro; Agustin F Fernández; Angela Moncada-Pazos; Alvaro J Obaya; Oscar Aguilera; José Manuel González-Sancho; Laura Sánchez; AURORA ASTUDILLO; Alberto Muñoz; Carlos López-Otín; Manel Esteller; Mario F Fraga
Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer.
Molecular cancer 2010;9():170.
2009: María Berdasco; Santiago Ropero; Fernando Setien; Mario F Fraga; Pablo Lapunzina; Régine Losson; Miguel Alaminos; Nai-Kong V Cheung; Nazneen Rahman; Manel Esteller
Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(51):21830-5.
2009: Vincenzo Calvanese; Ester Lara; Arnold Kahn; Mario F Fraga
The role of epigenetics in aging and age-related diseases.
Ageing research reviews 2009;8(4):268-76.
2009: Gianni García-Faroldi; Florencia Correa-Fiz; Hicham Abrighach; María Berdasco; Mario F Fraga; Manel Esteller; José Luis Urdiales; Francisca Sánchez-Jiménez; Ignacio Fajardo
Polyamines affect histamine synthesis during early stages of IL-3-induced bone marrow cell differentiation.
Journal of cellular biochemistry 2009;108(1):261-71.
2009: Angela Moncada-Pazos; Alvaro J Obaya; Mario F Fraga; Cristina G Viloria; Gabriel Capellá; Mireia Gausachs; Manel Esteller; Carlos López-Otín; Santiago Cal
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
Journal of cell science 2009;122(Pt 16):2906-13.
2009: Mario F Fraga
Genetic and epigenetic regulation of aging.
Current opinion in immunology 2009;21(4):446-53.
2009: Isabel López de Silanes; Myriam Gorospe; Hiroaki Taniguchi; Kotb Abdelmohsen; Subramanya Srikantan; Miguel Alaminos; María Berdasco; Rocío G Urdinguio; Mario F Fraga; Filipe V Jacinto; Manel Esteller
The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA.
Nucleic acids research 2009;37(8):2658-71.
2009: E Lara; A Mai; Vincenzo Calvanese; L Altucci; P Lopez-Nieva; M L Martinez-Chantar; M Varela-Rey; dante rotili; A Nebbioso; Santiago Ropero; G Montoya; J Oyarzabal; S Velasco; M Serrano; M Witt; Ana Villar-Garea; A Imhof; A Inhof; J M Mato; Manel Esteller; Mario F Fraga
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
Oncogene 2009;28(6):781-91.
2009: María Berdasco; Mario F Fraga; Manel Esteller
Quantification of global DNA methylation by capillary electrophoresis and mass spectrometry.
Methods in molecular biology (Clifton, N.J.) 2009;507():23-34.
2008: E Vera; Andrés Canela; Mario F Fraga; Manel Esteller; María A Blasco
Epigenetic regulation of telomeres in human cancer.
Oncogene 2008;27(54):6817-33.
2008: Lidia Lopez-Serra; Esteban Ballestar; Santiago Ropero; Fernando Setien; L-M Billard; Mario F Fraga; P Lopez-Nieva; Miguel Alaminos; D Guerrero; R Dante; Manel Esteller
Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins.
Oncogene 2008;27(25):3556-66.
2008: Mario F Fraga; Maria Berdasco; Esteban Ballestar; Santiago Ropero; Pilar Lopez-Nieva; Lidia Lopez-Serra; José I Martín-Subero; Maria J Calasanz; Isabel Lopez de Silanes; Fernando Setien; Sara Casado; Agustin F Fernandez; Reiner Siebert; Stefano Stifani; Manel Esteller
Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies.
Cancer research 2008;68(11):4116-22.
2008: María Berdasco; Ruben Alcazar; María Victoria García-Ortiz; Esteban Ballestar; Agustín F Fernández; Teresa Roldán-Arjona; Antonio F Tiburcio; Teresa Altabella; Nicolas Buisine; Hadi Quesneville; Antoine Baudry; Loïc Lepiniec; Miguel Alaminos; Roberto Rodríguez; Alan Lloyd; Vincent Colot; Judith Bender; María Jesús Canal; Manel Esteller; Mario F Fraga
Promoter DNA hypermethylation and gene repression in undifferentiated Arabidopsis cells.
PloS one 2008;3(10):e3306.
2008: Vincenzo Calvanese; Angelica Horrillo; Abdelkrim Hmadcha; Beatriz Suarez-Alvarez; Agustín F Fernandez; Ester Lara; Sara Casado; Pablo Menendez; Clara Bueno; Javier Garcia-Castro; Ruth Rubio; Pablo Lapunzina; Miguel Alaminos; Lodovica Borghese; Stefanie Terstegge; Neil J Harrison; Harry D Moore; Oliver Brüstle; Carlos Lopez-Larrea; Peter W Andrews; Bernat Soria; Manel Esteller; Mario F Fraga
Cancer genes hypermethylated in human embryonic stem cells.
PloS one 2008;3(9):e3294.
2007: David Blanco; Silvestre Vicent; Mario F Fraga; Ignacio Fernandez-Garcia; Javier Freire; amaia lujambio; Manel Esteller; Carlos Ortiz de Solorzano; Ruben Pio; Fernando Lecanda; Luis M Montuenga
Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway.
Neoplasia (New York, N.Y.) 2007;9(10):840-52.
2007: Oscar Aguilera; Cristina Peña; José M García; María Jesús Larriba; Paloma Ordóñez-Morán; Diego Navarro; Antonio Barbáchano; Isabel López De Silanes; Esteban Ballestar; Mario F Fraga; Manel Esteller; Carlos Gamallo; Félix Bonilla; José Manuel González-Sancho; Alberto Muñoz
The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells.
Carcinogenesis 2007;28(9):1877-84.
2007: Rosalia Caballero; Fernando Setien; Lidia Lopez-Serra; Manuel Boix-Chornet; Mario F Fraga; Santiago Ropero; Diego Megias; Miguel Alaminos; Eva M Sanchez-Tapia; Maria C Montoya; Manel Esteller; Rogelio Gonzalez-Sarmiento; Esteban Ballestar
Combinatorial effects of splice variants modulate function of Aiolos.
Journal of cell science 2007;120(Pt 15):2619-30.
2007: Mario F Fraga; Manel Esteller
Epigenetics and aging: the targets and the marks.
Trends in genetics : TIG 2007;23(8):413-8.
2007: D Perrin; Esteban Ballestar; Mario F Fraga; Lucien Frappart; M Esteller; Jean François Guerin; Robert Dante
Specific hypermethylation of LINE-1 elements during abnormal overgrowth and differentiation of human placenta.
Oncogene 2007;26(17):2518-24.
2007: Mario F Fraga; Ruben Agrelo; Manel Esteller
Cross-talk between aging and cancer: the epigenetic language.
Annals of the New York Academy of Sciences 2007;1100():60-74.
2007: Oscar Aguilera; Alberto Muñoz; Manel Esteller; Mario F Fraga
Epigenetic alterations of the Wnt/beta-catenin pathway in human disease.
Endocrine, metabolic & immune disorders drug targets 2007;7(1):13-21.
2007: amaia lujambio; Santiago Ropero; Esteban Ballestar; Mario F Fraga; Celia Cerrato; Fernando Setién; Sara Casado; Ana Suarez-Gauthier; Montserrat Sanchez-Cespedes; Anna Git; Anna Gitt; Inmaculada Spiteri; Partha P Das; Carlos Caldas; Eric A Miska; Manel Esteller
Genetic unmasking of an epigenetically silenced microRNA in human cancer cells.
Cancer research 2007;67(4):1424-9.
2007: Rocio G Urdinguio; Irene Pino; Santiago Ropero; Mario F Fraga; Manel Esteller
Histone H3 and H4 modification profiles in a Rett syndrome mouse model.
Epigenetics : official journal of the DNA Methylation Society 2007;2(1):11-4.
2007: Jesus Espada; Esteban Ballestar; Raffaella Santoro; Mario F Fraga; Ana Villar-Garea; Attila Németh; Lidia Lopez-Serra; Santiago Ropero; Agustin Aranda; Helena Orozco; Vanessa Moreno; Angeles Juarranz; Juan C Stockert; Gernot Längst; Ingrid Grummt; Wendy A Bickmore; Manel Esteller
Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells.
Nucleic acids research 2007;35(7):2191-8.
2006: Lidia Lopez-Serra; Esteban Ballestar; Mario F Fraga; Miguel Alaminos; Fernando Setien; Manel Esteller
A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer.
Cancer research 2006;66(17):8342-6.
2006: Arancha Cebrian; Paul D P Pharoah; Shahana Ahmed; Santiago Ropero; Mario F Fraga; Paula L Smith; Donald M Conroy; Robert Luben; Barbara Perkins; Douglas F Easton; Alison M Dunning; Manel Esteller; Bruce A J Ponder
Genetic variants in epigenetic genes and breast cancer risk.
Carcinogenesis 2006;27(8):1661-9.
2006: Oscar Aguilera; Mario F Fraga; Esteban Ballestar; Maria Fe Paz; Michel Herranz; Jesus Espada; José M García; Alberto Muñoz; Manel Esteller; José Manuel González-Sancho
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.
Oncogene 2006;25(29):4116-21.
2006: Ruben Agrelo; Wen-Hsing Cheng; Fernando Setien; Santiago Ropero; Jesus Espada; Mario F Fraga; Michel Herranz; Maria Fe Paz; Montserrat Sanchez-Cespedes; María-Jesús Artiga; David Guerrero; Antoni Castells; Cayetano von Kobbe; Vilhelm A Bohr; Manel Esteller
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8822-7.
2006: Manuel Boix-Chornet; Mario F Fraga; Ana Villar-Garea; Rosalia Caballero; Jesus Espada; Antonio Nuñez; Juan Casado; Cristina Largo; J Ignacio Casal; Juan C Cigudosa; Luis Franco; Manel Esteller; Esteban Ballestar
Release of hypoacetylated and trimethylated histone H4 is an epigenetic marker of early apoptosis.
The Journal of biological chemistry 2006;281(19):13540-7.
2006: Santiago Ropero; Mario F Fraga; Esteban Ballestar; Richard Hamelin; Hiroyuki Yamamoto; Manuel Boix-Chornet; Rosalia Caballero; Miguel Alaminos; Fernando Setien; Maria Fe Paz; Michel Herranz; José Palacios; Diego Arango; Torben F Orntoft; Lauri A Aaltonen; Simó Schwartz; Manel Esteller
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition.
Nature genetics 2006;38(5):566-9.
2006: Sonia Mulero-Navarro; José María Carvajal-Gonzalez; Michel Herranz; Esteban Ballestar; Mario F Fraga; Santiago Ropero; Manel Esteller; Pedro M Fernandez-Salguero
The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding.
Carcinogenesis 2006;27(5):1099-104.
2006: M Matabuena de Yzaguirre; J Santos Hernández; P Fernández Navarro; P López Nieva; Michel Herranz; Mario F Fraga; Manel Esteller; Angeles Juarranz; José Fernández-Piqueras
Epigenetic silencing of E- and N-cadherins in the stroma of mouse thymic lymphomas.
Carcinogenesis 2006;27(5):1081-9.
2006: Susana Gonzalo; Isabel Jaco; Mario F Fraga; Taiping Chen; En Li; Manel Esteller; María A Blasco
DNA methyltransferases control telomere length and telomere recombination in mammalian cells.
Nature cell biology 2006;8(4):416-24.
2006: Debby M E I Hellebrekers; Kam-Wing Jair; Emmanuelle Viré; Sayaka Eguchi; Nicole T H Hoebers; Mario F Fraga; Manel Esteller; François Fuks; Stephen B Baylin; Manon van Engeland; Arjan W Griffioen
Angiostatic activity of DNA methyltransferase inhibitors.
Molecular cancer therapeutics 2006;5(2):467-75.
2006: Michel Herranz; Juan Martín-Caballero; Mario F Fraga; Jesús Ruiz-Cabello; Juana M Flores; Manuel Desco; Victor Marquez; Manel Esteller
The novel DNA methylation inhibitor zebularine is effective against the development of murine T-cell lymphoma.
Blood 2006;107(3):1174-7.
2005: Mario F Fraga; Manel Esteller
Towards the human cancer epigenome: a first draft of histone modifications.
Cell cycle (Georgetown, Tex.) 2005;4(10):1377-81.
2005: Mario F Fraga; Esteban Ballestar; Maria Fe Paz; Santiago Ropero; Fernando Setien; Maria L Ballestar; DAMIA HEINE; Juan C Cigudosa; Miguel Urioste; Javier Benitez; Manuel Boix-Chornet; Abel Sanchez-Aguilera; Charlotte Ling; Emma Carlsson; Pernille Poulsen; Allan Vaag; Zarko Stephan; Tim D Spector; Yue-Zhong Wu; Christoph Plass; Manel Esteller
Epigenetic differences arise during the lifetime of monozygotic twins.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10604-9.
2005: Ruben Agrelo; Fernando Setien; Jesus Espada; María-Jesús Artiga; Maria M Rodriguez; Alberto Pérez-Rosado; Abel Sanchez-Aguilera; Mario F Fraga; Miguel A Piris; Manel Esteller
Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(17):3940-7.
2005: Miguel Alaminos; Verónica Dávalos; Santiago Ropero; Fernando Setién; Maria Fe Paz; Michel Herranz; Mario F Fraga; Jaume Mora; Nai-Kong V Cheung; William L Gerald; Manel Esteller
EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.
Cancer research 2005;65(7):2565-71.
2005: Mario F Fraga; Esteban Ballestar; Ana Villar-Garea; Manuel Boix-Chornet; Jesus Espada; Gunnar Schotta; Tiziana Bonaldi; Claire Haydon; Santiago Ropero; Kevin Petrie; N Gopalakrishna Iyer; Alberto Pérez-Rosado; Enrique Calvo; Juan A Lopez; Amparo Cano; María J Calasanz; Dolors Colomer; Miguel A Piris; Natalie Ahn; Axel imhof; Carlos Caldas; Thomas Jenuwein; Manel Esteller
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.
Nature genetics 2005;37(4):391-400.
2005: Susana Gonzalo; Marta García-Cao; Mario F Fraga; Gunnar Schotta; Antoine H F M Peters; Shane E Cotter; Raúl Eguía; Douglas C Dean; Manel Esteller; Thomas Jenuwein; María A Blasco
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.
Nature cell biology 2005;7(4):420-8.
2005: Esteban Ballestar; Santiago Ropero; Miguel Alaminos; Judith Armstrong; Fernando Setien; Ruben Agrelo; Mario F Fraga; Michel Herranz; Sonia Avila; Manuel Pineda; Eugenia Monros; Manel Esteller
The impact of MECP2 mutations in the expression patterns of Rett syndrome patients.
Human genetics 2005;116(1-2):91-104.
2004: Santiago Ropero; Fernando Setien; Jesus Espada; Mario F Fraga; Michel Herranz; Julia Asp; Maria Serena Benassi; Alessandro Franchi; Ana Patiño; Laura S Ward; Judith Bovee; Juan C Cigudosa; Wuyts Wim; Manel Esteller
Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.
Human molecular genetics 2004;13(22):2753-65.
2004: Manuel Irimia; Mario F Fraga; Montserrat Sanchez-Cespedes; Manel Esteller
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
Oncogene 2004;23(53):8695-9.
2004: Pedro P Medina; Julian Carretero; Mario F Fraga; Manel Esteller; David Sidransky; Montserrat Sanchez-Cespedes
Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors.
Genes, chromosomes & cancer 2004;41(2):170-7.
2004: Jesus Espada; Esteban Ballestar; Mario F Fraga; Ana Villar-Garea; Angeles Juarranz; Juan C Stockert; Keith D Robertson; François Fuks; Manel Esteller
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.
The Journal of biological chemistry 2004;279(35):37175-84.
2004: Mario F Fraga; Michel Herranz; Jesus Espada; Esteban Ballestar; Maria Fe Paz; Santiago Ropero; Emel Erkek; Onder Bozdogan; Héctor Peinado; Alain Niveleau; Jian-Hua Mao; Allan Balmain; Amparo Cano; Manel Esteller
A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors.
Cancer research 2004;64(16):5527-34.
2004: David Blanco; Silvestre Vicent; Eider Elizegi; Irene Pino; Mario F Fraga; Manel Esteller; Umberto Saffiotti; Fernando Lecanda; Luis M Montuenga
Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis.
Laboratory investigation; a journal of technical methods and pathology 2004;84(8):999-1012.
2004: Gertrud Lund; Linda Andersson; Massimiliano Lauria; Marie W Lindholm; Mario F Fraga; Ana Villar-Garea; Esteban Ballestar; Manel Esteller; Silvio Zaina
DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E.
The Journal of biological chemistry 2004;279(28):29147-54.
2003: Esteban Ballestar; Maria Fe Paz; Laura Valle; Susan Wei; Mario F Fraga; Jesus Espada; Juan C Cigudosa; Hui-Ming (Tim) Huang; Manel Esteller
Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.
The EMBO journal 2003;22(23):6335-45.
2003: Ana Villar-Garea; Mario F Fraga; Jesus Espada; Manel Esteller
Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.
Cancer research 2003;63(16):4984-9.
2003: Mario F Fraga; Esteban Ballestar; Manel Esteller
Capillary electrophoresis-based method to quantitate DNA-protein interactions.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;789(2):431-5.
2003: Mario F Fraga; Esteban Ballestar; Guillermo Montoya; Panya Taysavang; Paul A Wade; Manel Esteller
The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties.
Nucleic acids research 2003;31(6):1765-74.
2003: Maria Fe Paz; Mario F Fraga; Sonia Avila; Mingzhou Guo; Marina Pollan; James G Herman; Manel Esteller
A systematic profile of DNA methylation in human cancer cell lines.
Cancer research 2003;63(5):1114-21.
2003: Victoria Bolós; Héctor Peinado; Mirna A Pérez-Moreno; Mario F Fraga; Manel Esteller; Amparo Cano
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors.
Journal of cell science 2003;116(Pt 3):499-511.
2002: Manel Esteller; Mario F Fraga; Maria Fe Paz; Elias Campo; Dolors Colomer; Francisco J Novo; María J Calasanz; Oliver Galm; Mingzhou Guo; Javier Benitez; James G Herman
Cancer epigenetics and methylation.
Science (New York, N.Y.) 2002;297(5588):1807-8; discussion 1807-8.
2002: Mario F Fraga; Manel Esteller
DNA methylation: a profile of methods and applications.
BioTechniques 2002;33(3):632, 634, 636-49.
2002: Maria Fe Paz; Sonia Avila; Mario F Fraga; Marina Pollan; Gabriel Capella; Miguel A Peinado; Montserrat Sanchez-Cespedes; James G Herman; Manel Esteller
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.
Cancer research 2002;62(15):4519-24.
2001: Manel Esteller; Mario F Fraga; Mingzhou Guo; J Garcia-Foncillas; I Hedenfalk; A K Godwin; J Trojan; Catherine Vaurs-Barrière; Yves-Jean Bignon; S Ramus; J Benitez; T Caldes; Y Akiyama; Y Yuasa; Virpi Launonen; M J Canal; R Rodriguez; Gabriel Capella; Miguel A Peinado; A Borg; L A Aaltonen; bruce ponder; Stephen B Baylin; James G Herman
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.
Human molecular genetics 2001;10(26):3001-7.