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Genoveffa Franchini

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Natasa Strbo; Monica Vaccari; Donald Stablein; Melvin N Doster; Eva Fisher; Genoveffa Franchini; Louis Gonzalez; Michael A Kolber; Savita Pahwa; Eckhard R Podack
Cutting edge: novel vaccination modality provides significant protection against mucosal infection by highly pathogenic simian immunodeficiency virus.
Monica Vaccari; David Venzon; Steven E Bosinger; Melvin N Doster; Barbara K Felber; Claudio Fenizia; Guido Ferrari; Donald N Forthal; Yongjun Guan; Anna Hryniewicz; Brandon F Keele; Jeffrey D Lifson; Zhong-Min Ma; Chris J Miller; David Montefiori; Tia Morgan; George Pavlakis; Justin Pollara; Margherita Rosati; Guido Silvestri; James Tartaglia; Genoveffa Franchini
Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure.
Monica Vaccari; David Venzon; Saleh Al-Muhsen; Jennifer Beal; Adriano Boasso; Mohamed El-Far; Barbara K Felber; Elias K Haddad; Rabih Halwani; Anna Hryniewicz; L Jean Patterson; George Pavlakis; Marjorie Robert-Guroff; Margherita Rosati; Rafick-Pierre Sekaly; Elzbieta Tryniszewska; Genoveffa Franchini
Antibodies to gp120 and PD-1 expression on virus-specific CD8+ T cells in protection from simian AIDS.

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2013: Natasa Strbo; Monica Vaccari; Donald Stablein; Melvin N Doster; Eva Fisher; Genoveffa Franchini; Louis Gonzalez; Michael A Kolber; Savita Pahwa; Eckhard R Podack
Cutting edge: novel vaccination modality provides significant protection against mucosal infection by highly pathogenic simian immunodeficiency virus.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2495-9.
2013: Monica Vaccari; David Venzon; Steven E Bosinger; Melvin N Doster; Barbara K Felber; Claudio Fenizia; Guido Ferrari; Donald N Forthal; Yongjun Guan; Anna Hryniewicz; Brandon F Keele; Jeffrey D Lifson; Zhong-Min Ma; Chris J Miller; David Montefiori; Tia Morgan; George Pavlakis; Justin Pollara; Margherita Rosati; Guido Silvestri; James Tartaglia; Genoveffa Franchini
Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure.
Journal of virology 2013;87(6):3538-48.
2013: Monica Vaccari; David Venzon; Saleh Al-Muhsen; Jennifer Beal; Adriano Boasso; Mohamed El-Far; Barbara K Felber; Elias K Haddad; Rabih Halwani; Anna Hryniewicz; L Jean Patterson; George Pavlakis; Marjorie Robert-Guroff; Margherita Rosati; Rafick-Pierre Sekaly; Elzbieta Tryniszewska; Genoveffa Franchini
Antibodies to gp120 and PD-1 expression on virus-specific CD8+ T cells in protection from simian AIDS.
Journal of virology 2013;87(6):3526-37.
2013: Daniel Mendoza; Stephen A Migueles; Bennett Peterson; Eva Rakasz; Julia E Rood; Douglas Schneider; Matthew Trivett; Charles M Trubey; David Watkins; Nicole Doria-Rose; Genoveffa Franchini; Claire W Hallahan; Sarah Johnson; Jeffrey D Lifson; Vicky Coalter; Mark Connors
Cytotoxic capacity of SIV-specific CD8(+) T cells against primary autologous targets correlates with immune control in SIV-infected rhesus macaques.
PLoS pathogens 2013;9(2):e1003195.
2013: Enrico Lugli; David A Price; Nicholas P Restifo; Kaimei Song; Monica Vaccari; Thomas A Waldmann; Diane L Bolton; Jason M Brenchley; Pratip K Chattopadhyay; Maria H Dominguez; Genoveffa Franchini; Luca Gattinoni; Emma Gostick; Nichole R Klatt; Mario Roederer
Superior T memory stem cell persistence supports long-lived T cell memory.
The Journal of clinical investigation 2013;123(2):594-9.
2013: Poonam Pegu; Mangala Rao; Donald Stablein; Jim Tartaglia; Georgia D Tomaras; Monica Vaccari; David Venzon; Stephen Whitney; Shari Gordon; Yongjun Guan; Lauren Hudacik; Brandon F Keele; Jerome Kim; Jeffrey D Lifson; Nelson Michael; David Montefiori; Ranajit Pal; S Munir Alam; Erik Billings; Melvin Doster; Claudio Fenizia; Guido Ferrari; Maria Grazia Ferrari; Genoveffa Franchini
Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial.
Journal of virology 2013;87(3):1708-19.
2013: Richard M Dunham; Genoveffa Franchini; Shari N Gordon; Yong Huang; Jeffrey Lifson; Michael Piatak; Monica Vaccari; Steven G Deeks; Joseph M McCune
Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.
AIDS research and human retroviruses 2013;29(2):207-14.
2011: Yongjun Sui; David Venzon; Yichuan Wang; Zheng Xia; Huifeng Yu; Qing Zhu; Amiran Dzutsev; Genoveffa Franchini; Susan Gagnon; Alison Hogg; Brian Kelsall; Dennis M Klinman; Warren Strober; Igor M Belyakov; Jay A Berzofsky
TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4⁺ memory T cell loss in SIVmac251-challenged rhesus macaques.
Vaccine 2011;30(1):59-68.
2011: Izabela Bialuk; Valentina Cecchinato; Thorsten Demberg; Ruth H Florese; Donald N Forthal; Vibeke Andresen; Shari Gordon; Marjorie Robert- Guroff; Jean-Michel Heraud; Gary Landucci; David C Montefiori; Janos Nacsa; Robyn Washington Parks; Valerio W Valeri; David Venzon; Stephen Whitney; Genoveffa Franchini
Vaccine induced antibodies to the first variable loop of human immunodeficiency virus type 1 gp120, mediate antibody-dependent virus inhibition in macaques.
Vaccine 2011;30(1):78-94.
2011: Claudio Fenizia; Nicolò Binello; Stefano Cornara; Vanessa M Hirsch; Brandon F Keele; Zhong-Min Ma; Christopher J Miller; David Nichols; Poonam Pegu; Marjorie Robert-Guroff; Monica Vaccari; David Venzon; Genoveffa Franchini
TRIM5α does not affect simian immunodeficiency virus SIV(mac251) replication in vaccinated or unvaccinated Indian rhesus macaques following intrarectal challenge exposure.
Journal of virology 2011;85(23):12399-409.
2011: Suresh Pallikkuth; Kenneth Rogers; Monica Vaccari; Francios VILLINGER; Melvin Dosterii; Genoveffa Franchini; Rajendra Pahwa; Savita Pahwa
Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication.
Vaccine 2011;29(49):9229-38.
2011: Giovanna Tosi; Marco Turci; Vibeke Andresen; Umberto Bertazzoni; Greta Forlani; Genoveffa Franchini; Guido Poli; Roberto Accolla
Major histocompatibility complex class II transactivator CIITA is a viral restriction factor that targets human T-cell lymphotropic virus type 1 Tax-1 function and inhibits viral replication.
Journal of virology 2011;85(20):10719-29.
2011: Vibeke Andresen; Marcia Bellon; Valentina Cecchinato; Risaku Fukumoto; Christophe Nicot; Cynthia A Pise-Masison; Uma Sinha-Datta; Valerio Valeri; R Washington Parks; Genoveffa Franchini
Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles.
Blood 2011;118(6):1549-59.
2011: Dustin Edwards; Claudio Fenizia; Cody Buchmann; Maria Fernanda de Castro-Amarante; Heather Gold; Cynthia A Pise-Masison; Genoveffa Franchini
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
Viruses 2011;3(6):861-85.
2011: Shari N Gordon; Valentina Cecchinato; Vibeke Andresen; Jean-Michel Heraud; Anna Hryniewicz; Robyn Washington Parks; David Venzon; Hye-kyung Chung; Tatiana Karpova; James McNally; Peter Silvera; Keith A Reimann; Hajime Matsui; Tomomi Kanehara; Yasuhiko Shinmura; Hiroyuki Yokote; Genoveffa Franchini
Smallpox vaccine safety is dependent on T cells and not B cells.
The Journal of infectious diseases 2011;203(8):1043-53.
2011: Natasa Strbo; Monica Vaccari; Savita Pahwa; Michael A Kolber; Eva Fisher; Louis Gonzalez; Melvin N Doster; Anna Hryniewicz; Barbara K Felber; George N Pavlakis; Genoveffa Franchini; Eckhard R Podack
Gp96 SIV Ig immunization induces potent polyepitope specific, multifunctional memory responses in rectal and vaginal mucosa.
Vaccine 2011;29(14):2619-25.
2010: Nancy Van Prooyen; Heather Gold; Vibeke Andresen; Owen Schwartz; Kathryn Jones; Frank Ruscetti; Stephen Lockett; Prabhakar Gudla; David Venzon; Genoveffa Franchini
Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(48):20738-43.
2010: Valerio W Valeri; Anna Hryniewicz; Vibeke Andresen; Kathy Jones; Claudio Fenizia; Izabela Bialuk; Hye Kyung Chung; Risaku Fukumoto; Robyn Washington Parks; Maria Grazia Ferrari; Christophe Nicot; Valentina Cecchinato; Francis W Ruscetti; Genoveffa Franchini
Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits.
Blood 2010;116(19):3809-17.
2010: Genoveffa Franchini
HTLV-1 and HIV-1 "accessory" proteins: a misleading misnomer.
Molecular aspects of medicine 2010;31(5):331-2.
2010: Nancy Van Prooyen; Vibeke Andresen; Heather Gold; Izabela Bialuk; Cynthia Pise-Masison; Genoveffa Franchini
Hijacking the T-cell communication network by the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) p12 and p8 proteins.
Molecular aspects of medicine 2010;31(5):333-43.
2010: Micol Silic-Benussi; Roberta Biasiotto; Vibeke Andresen; Genoveffa Franchini; Donna M D'Agostino; Vincenzo Ciminale
HTLV-1 p13, a small protein with a busy agenda.
Molecular aspects of medicine 2010;31(5):350-8.
2010: Monica Vaccari; Poonam Poonam; Genoveffa Franchini
Phase III HIV vaccine trial in Thailand: a step toward a protective vaccine for HIV.
Expert review of vaccines 2010;9(9):997-1005.
2010: Yongjun Sui; Qing Zhu; Susan Gagnon; Amiran Dzutsev; Masaki Terabe; Monica Vaccari; David Venzon; Dennis M Klinman; Warren Strober; Brian Kelsall; Genoveffa Franchini; Igor M Belyakov; Jay A Berzofsky
Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9843-8.
2010: Valentina Cecchinato; Genoveffa Franchini
Th17 cells in pathogenic simian immunodeficiency virus infection of macaques.
Current opinion in HIV and AIDS 2010;5(2):141-5.
2010: Shari N Gordon; Anna R Weissman; Valentina Cecchinato; Claudio Fenizia; Zhong-Min Ma; Tzong-Hae Lee; Lorenzo Zaffiri; Vibeke Andresen; Robyn Washington Parks; Kathryn Jones; Jean-Michel Heraud; Maria Grazia Ferrari; Hye Kyung Chung; David Venzon; Renaud Mahieux; Edward L Murphy; Steven Jacobson; Christopher J Miller; Francis W Ruscetti; Genoveffa Franchini
Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques.
Journal of virology 2010;84(6):3043-58.
2010: Magdalini Moutaftsi; David C Tscharke; Kerrie Vaughan; David M Koelle; Lawrence Stern; Mauricio Calvo-Calle; Francis Ennis; Masanori Terajima; Gerd Sutter; Shane Crotty; Ingo Drexler; Genoveffa Franchini; Jon W Yewdell; Steven R Head; Janice Blum; Bjoern Peters; Alex Sette
Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.
Future microbiology 2010;5(2):221-39.
2010: Monica Vaccari; Genoveffa Franchini
Memory T cells in Rhesus macaques.
Advances in experimental medicine and biology 2010;684():126-44.
2009: Maria E Moreno-Fernandez; Wildeman Zapata; Jason T Blackard; Genoveffa Franchini; Claire Chougnet
Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strain.
Journal of virology 2009;83(24):12925-33.
2009: Risaku Fukumoto; Vibeke Andresen; Izabela Bialuk; Valentina Cecchinato; Jean-Claude Walser; Valerio W Valeri; Julie M Nauroth; Antoine Gessain; Christophe Nicot; Genoveffa Franchini
In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein.
Blood 2009;113(16):3726-34.
2009: Adriano Boasso; Monica Vaccari; Dietmar Fuchs; Andrew W Hardy; Wen-Po Tsai; Elzbieta Tryniszewska; Gene M Shearer; Genoveffa Franchini
Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4313-20.
2009: Genoveffa Franchini
Choosing the right memory T cell for HIV.
Nature medicine 2009;15(3):244-6.
2009: Jean-Philippe Herbeuval; Jakob Nilsson; Adriano Boasso; Andrew W Hardy; Monica Vaccari; Valentina Cecchinato; Valerio Valeri; Genoveffa Franchini; Jan Andersson; Gene M Shearer
HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques.
AIDS (London, England) 2009;23(1):35-40.
2009: Miriam C Poirier; Ofelia A Olivero; Andrew W Hardy; Genoveffa Franchini; Jennifer P Borojerdi; Vernon E Walker; Dale M Walker; Gene M Shearer
Antiretroviral activity of the aminothiol WR1065 against Human Immunodeficiency virus (HIV-1) in vitro and Simian Immunodeficiency virus (SIV) ex vivo.
AIDS research and therapy 2009;6():24.
2008: Monica Vaccari; Joseph Mattapallil; Kaimei Song; Wen-Po Tsai; Anna Hryniewicz; David Venzon; Maurizio Zanetti; Keith A Reimann; Mario Roederer; Genoveffa Franchini
Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency.
Journal of virology 2008;82(19):9629-38.
2008: David R Kaufman; Jaap Goudsmit; Lennart Holterman; Bonnie A Ewald; Matthew Denholtz; Colleen Devoy; Ayush Giri; Lauren Grandpre; Jean-Michel Heraud; Genoveffa Franchini; Michael S Seaman; Menzo J E Havenga; Dan H Barouch
Differential antigen requirements for protection against systemic and intranasal vaccinia virus challenges in mice.
Journal of virology 2008;82(14):6829-37.
2008: Valentina Cecchinato; Elzbieta Tryniszewska; Zhong Min Ma; Monica Vaccari; Adriano Boasso; Wen-Po Tsai; Constantinos Petrovas; Dietmar Fuchs; Jean-Michel Heraud; David Venzon; Gene M Shearer; Richard A Koup; Israel Lowy; Christopher J Miller; Genoveffa Franchini
Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5439-47.
2007: Adriano Boasso; Monica Vaccari; Anna Hryniewicz; Dietmar Fuchs; Janos Nacsa; Valentina Cecchinato; Jan Andersson; Genoveffa Franchini; Gene M Shearer; Claire Chougnet
Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection.
Journal of virology 2007;81(21):11593-603.
2007: Risaku Fukumoto; Miroslav Dundr; Christophe Nicot; Anthony Adams; Valerio W Valeri; Lawrence E Samelson; Genoveffa Franchini
Inhibition of T-cell receptor signal transduction and viral expression by the linker for activation of T cells-interacting p12(I) protein of human T-cell leukemia/lymphoma virus type 1.
Journal of virology 2007;81(17):9088-99.
2007: Constantinos Petrovas; David A Price; Joseph J Mattapallil; David R Ambrozak; Christof Geldmacher; Valentina Cecchinato; Monica Vaccari; Elzbieta Tryniszewska; Emma Gostick; Mario Roederer; Daniel C Douek; Sara H Morgan; Simon J Davis; Genoveffa Franchini; Richard A Koup
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
Blood 2007;110(3):928-36.
2007: Anna Hryniewicz; David A Price; Marcin Moniuszko; Adriano Boasso; Yvette Edghill-Spano; Sadie M West; David Venzon; Monica Vaccari; Wen-Po Tsai; Elzbieta Tryniszewska; Janos Nacsa; Francios VILLINGER; Aftab A Ansari; Christopher J Trindade; Michel MORRE; David Brooks; Philip M Arlen; Helen J Brown; Christina Kitchen; Jerome A Zack; Daniel C Douek; Gene M Shearer; Mark G Lewis; Richard A Koup; Genoveffa Franchini
Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3492-504.
2007: Agneta S von Gegerfelt; margherita rosati; Candido Alicea; Antonio Valentin; Patricia Roth; Jenifer Bear; Genoveffa Franchini; Paul S Albert; Norbert Bischofberger; Jean D Boyer; David B Weiner; Phillip Markham; Zimra R Israel; John H Eldridge; George Pavlakis; Barbara K Felber
Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization.
Journal of virology 2007;81(4):1972-9.
2006: Marcin Moniuszko; Yvette Edghill Spano; David Venzon; Liljana Stevceva; Janos Nacsa; Elzbieta Tryniszewska; Wen-Po Tsai; Genoveffa Franchini
Decreased number of CD4+ and CD8+ T cells that express the interleukin-7 receptor in blood and tissues of SIV-infected macaques.
Virology 2006;356(1-2):188-97.
2006: Sofiane Ghorbel; Uma Sinha-Datta; Miroslav Dundr; Megan Brown; Genoveffa Franchini; Christophe Nicot
Human T-cell leukemia virus type I p30 nuclear/nucleolar retention is mediated through interactions with RNA and a constituent of the 60 S ribosomal subunit.
The Journal of biological chemistry 2006;281(48):37150-8.
2006: Jakob Nilsson; Adriano Boasso; Paula Andrea Velilla; Rui Zhang; Monica Vaccari; Genoveffa Franchini; Gene M Shearer; Jan Andersson; Claire Chougnet
HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.
Blood 2006;108(12):3808-17.
2006: Anna Hryniewicz; Adriano Boasso; Yvette Edghill Spano; Monica Vaccari; Dietmar Fuchs; David Venzon; Janos Nacsa; Michael R Betts; Wen-Po Tsai; Jean-Michel Heraud; Brigitte Beer; Diann Blanset; Claire Chougnet; Israel Lowy; Gene M Shearer; Genoveffa Franchini
CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques.
Blood 2006;108(12):3834-42.
2006: Maurizio Zanetti; Genoveffa Franchini
T cell memory and protective immunity by vaccination: is more better?
Trends in immunology 2006;27(11):511-7.
2006: Jean-Michel Heraud; Yvette Edghill Spano; Victor Ayala; Irene Kalisz; Janie Parrino; Vaniambadi S Kalyanaraman; Jody Manischewitz; Lisa R King; Anna Hryniewicz; Christopher J Trindade; Meredith Hassett; Wen-Po Tsai; David Venzon; Aysegul Nalca; Monica Vaccari; Peter Silvera; Mike Bray; Barney S Graham; Hana Golding; Jay W Hooper; Genoveffa Franchini
Subunit recombinant vaccine protects against monkeypox.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2552-64.
2006: Adriano Boasso; Monica Vaccari; Jakob Nilsson; Gene M Shearer; Jan Andersson; Valentina Cecchinato; Claire Chougnet; Genoveffa Franchini
Do regulatory T-cells play a role in AIDS pathogenesis?
AIDS reviews 2006;8(3):141-7.
2006: Igor M Belyakov; Vladimir Kuznetsov; Brian Kelsall; Dennis M Klinman; Marcin Moniuszko; Michael Lemon; Phillip D Markham; Ranajit Pal; John Clements; Mark G Lewis; Warren Strober; Genoveffa Franchini; Jay A Berzofsky
Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa.
Blood 2006;107(8):3258-64.
2006: Ranajit Pal; David Venzon; Sampa Santra; Vaniambadi S Kalyanaraman; David C Montefiori; Lindsey Hocker; Lauren Hudacik; Nicolas Rose; Janos Nacsa; Yvette Edghill Spano; Marcin Moniuszko; Zdenek Hel; Igor M Belyakov; Jay A Berzofsky; Robyn Washington Parks; Phillip D Markham; Norman L Letvin; Jim Tartaglia; Genoveffa Franchini
Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels.
Journal of virology 2006;80(8):3732-42.
2006: Elzbieta Tryniszewska; Maciej Kaczmarski; Sandra Colombini-Hatch; Genoveffa Franchini
[Detection of human herpesvirus type 8 (HHV-8) in the central nervous system in patients from Poland].
Przegla̧d epidemiologiczny 2006;60 Suppl 1():166.
2006: Zdenek Hel; Wen-Po Tsai; Elzbieta Tryniszewska; Janos Nacsa; Phillip D Markham; Mark G Lewis; George Pavlakis; Barbara K Felber; Jim Tartaglia; Genoveffa Franchini
Improved vaccine protection from simian AIDS by the addition of nonstructural simian immunodeficiency virus genes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):85-96.
2005: Monica Vaccari; Christopher J Trindade; David Venzon; Maurizio Zanetti; Genoveffa Franchini
Vaccine-induced CD8+ central memory T cells in protection from simian AIDS.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3502-7.
2005: Christophe Nicot; Robert Harrod; Vincenzo Ciminale; Genoveffa Franchini
Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions.
Oncogene 2005;24(39):6026-34.
2005: Yvette Edghill Spano; Hana Golding; Jody Manischewitz; Lisa R King; Dorothy Scott; Mike Bray; Aysegul Nalca; Jay W Hooper; Chris A Whitehouse; Joern schmitz; Keith A Reimann; Genoveffa Franchini
Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus.
Nature medicine 2005;11(7):740-7.
2005: Marcin Moniuszko; Derek Bogdan; Ranajit Pal; David Venzon; Liljana Stevceva; Janos Nacsa; Elzbieta Tryniszewska; Yvette Edghill Spano; Steven Wolinsky; Genoveffa Franchini
Correlation between viral RNA levels but not immune responses in plasma and tissues of macaques with long-standing SIVmac251 infection.
Virology 2005;333(1):159-68.
2005: Janos Nacsa; Yvette Edghill Spano; Wen-Po Tsai; David Venzon; Elzbieta Tryniszewska; Anna Hryniewicz; Marcin Moniuszko; Audrey Kinter; Kendall A Smith; Genoveffa Franchini
Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):1913-21.
2005: Koen K A Van Rompay; Kristina Abel; Jonathan R Lawson; Raman P Singh; Kimberli A Schmidt; Thomas Evans; Patricia Earl; Danielle Harvey; Genoveffa Franchini; Jim Tartaglia; David Montefiori; Shilpa Hattangadi; Bernard Moss; Marta L Marthas
Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV.
Journal of acquired immune deficiency syndromes (1999) 2005;38(2):124-34.
2005: Yvette Edghill Spano; Mike Bray; Chris A Whitehouse; David Miller; Eric Mucker; Jody Manischewitz; Lisa R King; Marjorie Robert-Guroff; Anna Hryniewicz; David Venzon; Clement A Meseda; Jerry Weir; Aysegul Nalca; Virginia Livingston; Jay Wells; Mark G Lewis; John W Huggins; Susan H Zwiers; Hana Golding; Genoveffa Franchini
Smallpox vaccine does not protect macaques with AIDS from a lethal monkeypox virus challenge.
The Journal of infectious diseases 2005;191(3):372-81.
2005: Edward Murphy; Steven Jacobson; Genoveffa Franchini; Graham P Taylor; Barrie Hanchard; Owen Morgan; Michael D Lairmore
International Retrovirology Association brings together scientists and clinicians to bridge discoveries about human T-lymphotropic viruses from the laboratory to clinical trials.
Retrovirology 2005;2():22.
2004: David A Price; Sadie M West; Michael R Betts; Laura E Ruff; Jason M Brenchley; David R Ambrozak; Yvette Edghill Spano; Marcelo J Kuroda; Derek Bogdan; Kevin Kunstman; Norman L Letvin; Genoveffa Franchini; Steven Wolinsky; Richard A Koup; Daniel C Douek
T cell receptor recognition motifs govern immune escape patterns in acute SIV infection.
Immunity 2004;21(6):793-803.
2004: Ihab Younis; Lyne Khair; Miroslav Dundr; Michael D Lairmore; Genoveffa Franchini; Patrick L Green
Repression of human T-cell leukemia virus type 1 and type 2 replication by a viral mRNA-encoded posttranscriptional regulator.
Journal of virology 2004;78(20):11077-83.
2004: Marcin Moniuszko; Terry J Fry; Wen-Po Tsai; Michel MORRE; Brigitte Assouline; Pierre Cortez; Mark G Lewis; J S Cairns; CRYSTAL MACKALL; Genoveffa Franchini
Recombinant interleukin-7 induces proliferation of naive macaque CD4+ and CD8+ T cells in vivo.
Journal of virology 2004;78(18):9740-9.
2004: Genoveffa Franchini; Sanjay Gurunathan; Lynn Baglyos; Stanley Plotkin; Jim Tartaglia
Poxvirus-based vaccine candidates for HIV: two decades of experience with special emphasis on canarypox vectors.
Expert review of vaccines 2004;3(4 Suppl):S75-88.
2004: Robert B Belshe; Genoveffa Franchini; Marc P Girard; Frances Gotch; Pontiano Kaleebu; Marta L Marthas; Michael B McChesney; Rose McCullough; Fred Mhalu; Dominique Salmon-Ceron; Rafick-Pierre Sekaly; Koen K A Van Rompay; Bernard Verrier; Britta Wahren; Mercedes Weissenbacher
Support for the RV144 HIV vaccine trial.
Science (New York, N.Y.) 2004;305(5681):177-80; author reply 177-80.
2004: Liljana Stevceva; Marcin Moniuszko; Xavier Alvarez; Andrew Lackner; Genoveffa Franchini
Functional simian immunodeficiency virus Gag-specific CD8+ intraepithelial lymphocytes in the mucosae of SIVmac251- or simian-human immunodeficiency virus KU2-infected macaques.
Virology 2004;319(2):190-200.
2004: Christophe Nicot; Miroslav Dundr; Julie M Johnson; Jake R Fullen; Norma Alonzo; Risaku Fukumoto; Gerald Princler; David Derse; Tom Misteli; Genoveffa Franchini
HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication.
Nature medicine 2004;10(2):197-201.
2004: Janos Nacsa; Antonia Radaelli; Yvette Edghill Spano; David Venzon; Wen-Po Tsai; Carlo De Giuli Morghen; Dennis Panicali; Jim Tartaglia; Genoveffa Franchini
Avipox-based simian immunodeficiency virus (SIV) vaccines elicit a high frequency of SIV-specific CD4+ and CD8+ T-cell responses in vaccinia-experienced SIVmac251-infected macaques.
Vaccine 2004;22(5-6):597-606.
2003: Maria Grazia Ferrari; Liljana Stevceva; Phillip Markham; Genoveffa Franchini
Species-specific transformation of T cells by HV(MNE).
Virology 2003;317(2):299-307.
2003: Genoveffa Franchini; Risaku Fukumoto; Jake R Fullen
T-cell control by human T-cell leukemia/lymphoma virus type 1.
International journal of hematology 2003;78(4):280-96.
2003: Marcin Moniuszko; Charlie Brown; Ranajit Pal; Elzbieta Tryniszewska; Wen-Po Tsai; Vanessa M Hirsch; Genoveffa Franchini
High frequency of virus-specific CD8+ T cells in the central nervous system of macaques chronically infected with simian immunodeficiency virus SIVmac251.
Journal of virology 2003;77(22):12346-51.
2003: Yvette Edghill Spano; David Venzon; Tatiana S Karpova; James McNally; Janos Nacsa; Wen-Po Tsai; Elzbieta Tryniszewska; Marcin Moniuszko; Jody Manischewitz; Lisa R King; Steven J Snodgrass; John Parrish; Phillip Markham; Marsha Sowers; Derrick Martin; Mark G Lewis; Jay A Berzofsky; Igor M Belyakov; Bernard Moss; Jim Tartaglia; Mike Bray; Vanessa M Hirsch; Hana Golding; Genoveffa Franchini
Modeling a safer smallpox vaccination regimen, for human immunodeficiency virus type 1-infected patients, in immunocompromised macaques.
The Journal of infectious diseases 2003;188(8):1181-91.
2003: Igor M Belyakov; Patricia L Earl; Amiran Dzutsev; Vladimir Kuznetsov; Michael Lemon; Linda S Wyatt; James T Snyder; Jeffrey D Ahlers; Genoveffa Franchini; Bernard Moss; Jay A Berzofsky
Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9458-63.
2003: Antonia Radaelli; Janos Nacsa; Wen-Po Tsai; Yvette Edghill Spano; Carlo Zanotto; Veronica Elli; David Venzon; Elzbieta Tryniszewska; Phillip Markham; Gail P Mazzara; Dennis Panicali; Carlo De Giuli Morghen; Genoveffa Franchini
Prior DNA immunization enhances immune response to dominant and subdominant viral epitopes induced by a fowlpox-based SIVmac vaccine in long-term slow-progressor macaques infected with SIVmac251.
Virology 2003;312(1):181-95.
2003: Richard F Little; Stefania Pittaluga; Nicole Grant; Seth M Steinberg; Mark F Kavlick; Hiroaki Mitsuya; Genoveffa Franchini; Martin Gutierrez; Mark Raffeld; Elaine S Jaffe; Gene Shearer; Robert Yarchoan; Wyndham H Wilson
Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology.
Blood 2003;101(12):4653-9.
2003: Robert Harrod; Janos Nacsa; Carine Van Lint; Jeremy Hansen; Tatiana S Karpova; James McNally; Genoveffa Franchini
Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription.
The Journal of biological chemistry 2003;278(14):12310-8.
2003: Terry J Fry; Marcin Moniuszko; Stephen Creekmore; Susan J Donohue; Daniel C Douek; Steven Giardina; Toby T Hecht; Brenna J Hill; Kristin L Komschlies; Joseph Tomaszewski; Genoveffa Franchini; CRYSTAL MACKALL
IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates.
Blood 2003;101(6):2294-9.
2003: Janos Nacsa; Jennifer Stanton; Kevin Kunstman; Wen-Po Tsai; David Ian Watkins; Steven Wolinsky; Genoveffa Franchini
Emergence of cytotoxic T lymphocyte escape mutants following antiretroviral treatment suspension in rhesus macaques infected with SIVmac251.
Virology 2003;305(1):210-8.
2003: Genoveffa Franchini; Christophe Nicot; Julie M Johnson
Seizing of T cells by human T-cell leukemia/lymphoma virus type 1.
Advances in cancer research 2003;89():69-132.
2002: Genoveffa Franchini; Janos Nacsa; Zdenek Hel; Elzbieta Tryniszewska
Immune intervention strategies for HIV-1 infection of humans in the SIV macaque model.
Vaccine 2002;20 Suppl 4():A52-60.
2002: Zdenek Hel; Janos Nacsa; Wen-Po Tsai; Arthur Thornton; Laura Giuliani; Jim Tartaglia; Genoveffa Franchini
Equivalent immunogenicity of the highly attenuated poxvirus-based ALVAC-SIV and NYVAC-SIV vaccine candidates in SIVmac251-infected macaques.
Virology 2002;304(1):125-34.
2002: Elzbieta Tryniszewska; Janos Nacsa; Mark G Lewis; Peter Silvera; David Montefiori; David Venzon; Zdenek Hel; Robyn Washington Parks; Marcin Moniuszko; Jim Tartaglia; Kendall A Smith; Genoveffa Franchini
Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5347-57.
2002: Zdenek Hel; Janos Nacsa; Elzbieta Tryniszewska; Wen-Po Tsai; Robyn Washington Parks; David C Montefiori; Barbara K Felber; Jim Tartaglia; George Pavlakis; Genoveffa Franchini
Containment of simian immunodeficiency virus infection in vaccinated macaques: correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):4778-87.
2002: Liljana Stevceva; Xavier Alvarez; Andrew Lackner; Elzbieta Tryniszewska; Brian Kelsall; Janos Nacsa; Jim Tartaglia; Warren Strober; Genoveffa Franchini
Both mucosal and systemic routes of immunization with the live, attenuated NYVAC/simian immunodeficiency virus SIV(gpe) recombinant vaccine result in gag-specific CD8(+) T-cell responses in mucosal tissues of macaques.
Journal of virology 2002;76(22):11659-76.
2002: Zdenek Hel; Elzbieta Tryniszewska; Wen-Po Tsai; Julie M Johnson; Robert Harrod; Jake R Fullen; Vaniambadi S Kalyanaraman; John D Altman; James McNally; Tatiana S Karpova; Barbara K Felber; Jim Tartaglia; Genoveffa Franchini
Design and in vivo immunogenicity of a polyvalent vaccine based on SIVmac regulatory genes.
DNA and cell biology 2002;21(9):619-26.
2002: Julie M Johnson; Genoveffa Franchini
Retroviral proteins that target the major histocompatibility complex class I.
Virus research 2002;88(1-2):119-27.
2002: Zdenek Hel; Julie M Johnson; Elzbieta Tryniszewska; Wen-Po Tsai; Robert Harrod; Jake R Fullen; Jim Tartaglia; Genoveffa Franchini
A novel chimeric Rev, Tat, and Nef (Retanef) antigen as a component of an SIV/HIV vaccine.
Vaccine 2002;20(25-26):3171-86.
2002: Sampa Santra; Joern schmitz; Marcelo J Kuroda; Michelle A Lifton; Christine E Nickerson; Carol I Lord; Ranajit Pal; Genoveffa Franchini; Norman L Letvin
Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeys.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1847-53.
2002: Maria S Pombo-de-Oliveira; Jane A Dobbin; Paula Loureiro; Davimar Miranda Borducchi; Raquel C Maia; Marcia A Fernandes; Geraldo B Cavalcanti; Shigeki Takemoto; Genoveffa Franchini
Genetic mutation and early onset of T-cell leukemia in pediatric patients infected at birth with HTLV-I.
Leukemia research 2002;26(2):155-61.
2002: Bianca R Mothé; Helen Horton; Donald K Carter; Todd M Allen; Max E Liebl; Pam Skinner; Thorsten U Vogel; Sarah Fuenger; Kathy Vielhuber; William M Rehrauer; Nancy Wilson; Genoveffa Franchini; John D Altman; Ashley Haase; Louis J Picker; David Allison; David Ian Watkins
Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection.
Journal of virology 2002;76(2):875-84.
2002: Ranajit Pal; David Venzon; Norman L Letvin; Sampa Santra; David C Montefiori; Neil R Miller; Elzbieta Tryniszewska; Mark G Lewis; Thomas C VanCott; Vanessa M Hirsch; ruth woodward; A Gibson; M Grace; E Dobratz; Phillip D Markham; Zdenek Hel; Janos Nacsa; M Klein; Jim Tartaglia; Genoveffa Franchini
ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency.
Journal of virology 2002;76(1):292-302.
2002: Liljana Stevceva; Brian Kelsall; Janos Nacsa; Marcin Moniuszko; Zdenek Hel; Elzbieta Tryniszewska; Genoveffa Franchini
Cervicovaginal lamina propria lymphocytes: phenotypic characterization and their importance in cytotoxic T-lymphocyte responses to simian immunodeficiency virus SIVmac251.
Journal of virology 2002;76(1):9-18.
2001: Zdenek Hel; Wen-Po Tsai; A Thornton; Janos Nacsa; Laura Giuliani; Elzbieta Tryniszewska; M Poudyal; David Venzon; X Wang; John D Altman; David Ian Watkins; Wuyuan Lu; Agneta S von Gegerfelt; Barbara K Felber; Jim Tartaglia; George Pavlakis; Genoveffa Franchini
Potentiation of simian immunodeficiency virus (SIV)-specific CD4(+) and CD8(+) T cell responses by a DNA-SIV and NYVAC-SIV prime/boost regimen.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(12):7180-91.
2001: Igor M Belyakov; Zdenek Hel; Brian Kelsall; Vladimir Kuznetsov; Jeffrey D Ahlers; Janos Nacsa; David Ian Watkins; Todd M Allen; A Sette; John D Altman; ruth woodward; Phillip D Markham; John Clements; Genoveffa Franchini; Warren Strober; Jay A Berzofsky
Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques.
Nature medicine 2001;7(12):1320-6.
2001: Zdenek Hel; Janos Nacsa; Brian Kelsall; Wen-Po Tsai; Norman L Letvin; Robyn Washington Parks; Elzbieta Tryniszewska; Louis J Picker; Mark G Lewis; Yvette Edghill Spano; Marcin Moniuszko; Ranajit Pal; Liljana Stevceva; John D Altman; Todd M Allen; D Watkins; José V Torres; Jay A Berzofsky; Igor M Belyakov; Warren Strober; Genoveffa Franchini
Impairment of Gag-specific CD8(+) T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques.
Journal of virology 2001;75(23):11483-95.
2001: Christophe Nicot; Renaud Mahieux; Cynthia A Pise-Masison; John Brady; Antoine Gessain; S Yamaoka; Genoveffa Franchini
Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.
Molecular and cellular biology 2001;21(21):7391-402.
2001: Maria Grazia Ferrari; ED Rivadeneira; Ruth F Jarrett; Liljana Stevceva; Shigeki Takemoto; Phillip Markham; Genoveffa Franchini
HV(MNE), a novel lymphocryptovirus related to Epstein-Barr virus, induces lymphoma in New Zealand White rabbits.
Blood 2001;98(7):2193-9.
2001: Christophe Nicot; JC Mulloy; Maria Grazia Ferrari; Julie M Johnson; K Fu; Risaku Fukumoto; R Trovato; Jake R Fullen; Warren J Leonard; Genoveffa Franchini
HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
Blood 2001;98(3):823-9.
2001: Julie M Johnson; Christophe Nicot; Jake R Fullen; Vincenzo Ciminale; L Casareto; JC Mulloy; S Jacobson; Genoveffa Franchini
Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein.
Journal of virology 2001;75(13):6086-94.
2001: Julie M Johnson; Robert Harrod; Genoveffa Franchini
Molecular biology and pathogenesis of the human T-cell leukaemia/lymphotropic virus Type-1 (HTLV-1).
International journal of experimental pathology 2001;82(3):135-47.
2001: Liljana Stevceva; Elzbieta Tryniszewska; Zdenek Hel; Janos Nacsa; Brian Kelsall; R Washington Parks; Genoveffa Franchini
Differences in time of virus appearance in the blood and virus-specific immune responses in intravenous and intrarectal primary SIVmac251 infection of rhesus macaques; a pilot study.
BMC infectious diseases 2001;1():9.
2000: L Jean Patterson; Bo Peng; Alash'Le Abimiku; Kristine Aldrich; L Murty; Phillip D Markham; Vaniambadi S Kalyanaraman; W Gregory Alvord; Jim Tartaglia; Genoveffa Franchini; Marjorie Robert-Guroff
Cross-protection in NYVAC-HIV-1-immunized/HIV-2-challenged but not in NYVAC-HIV-2-immunized/SHIV-challenged rhesus macaques.
AIDS (London, England) 2000;14(16):2445-55.
2000: Julie M Johnson; JC Mulloy; Vincenzo Ciminale; Jake R Fullen; Christophe Nicot; Genoveffa Franchini
The MHC class I heavy chain is a common target of the small proteins encoded by the 3' end of HTLV type 1 and HTLV type 2.
AIDS research and human retroviruses 2000;16(16):1777-81.
2000: Donna M D'Agostino; Lorenza Zotti; Tiziana Ferro; Genoveffa Franchini; Luigi Chieco-Bianchi; Vincenzo Ciminale
The p13II protein of HTLV type 1: comparison with mitochondrial proteins coded by other human viruses.
AIDS research and human retroviruses 2000;16(16):1765-70.
2000: Christophe Nicot; Rene Opavsky; Renaud Mahieux; J M Johnson; John N Brady; Linda Wolff; Genoveffa Franchini
Tax oncoprotein trans-represses endogenous B-myb promoter activity in human T cells.
AIDS research and human retroviruses 2000;16(16):1629-32.
2000: Zdenek Hel; David Venzon; M Poudyal; Wen-Po Tsai; Laura Giuliani; ruth woodward; Claire Chougnet; G Shearer; John D Altman; D Watkins; Norbert Bischofberger; Alash'Le Abimiku; Phillip Markham; Jim Tartaglia; Genoveffa Franchini
Viremia control following antiretroviral treatment and therapeutic immunization during primary SIV251 infection of macaques.
Nature medicine 2000;6(10):1140-6.
2000: Leonid Margolis; Svetlana Glushakova; Claire Chougnet; G Shearer; Phillip Markham; Marjorie Robert-Guroff; R Benveniste; Christopher J Miller; Martin Cranage; Vanessa M Hirsch; Genoveffa Franchini
Replication of simian immunodeficiency virus (SIV) in ex vivo lymph nodes as a means to assess susceptibility of macaques in vivo.
Virology 2000;275(2):391-7.
2000: Marcelo J Kuroda; Joern schmitz; C Lekutis; Christine E Nickerson; Michelle A Lifton; Genoveffa Franchini; Janet M Harouse; Cecilia Cheng-Mayer; Norman L Letvin
Human immunodeficiency virus type 1 envelope epitope-specific CD4(+) T lymphocytes in simian/human immunodeficiency virus-infected and vaccinated rhesus monkeys detected using a peptide-major histocompatibility complex class II tetramer.
Journal of virology 2000;74(18):8751-6.
2000: Gregory A Dekaban; AA Peters; JC Mulloy; Julie M Johnson; R Trovato; ED Rivadeneira; Genoveffa Franchini
The HTLV-I orfI protein is recognized by serum antibodies from naturally infected humans and experimentally infected rabbits.
Virology 2000;274(1):86-93.
2000: Christophe Nicot; Renaud Mahieux; Shigeki Takemoto; Genoveffa Franchini
Bcl-X(L) is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples.
Blood 2000;96(1):275-81.
2000: Shigeki Takemoto; R Trovato; A Cereseto; Christophe Nicot; T Kislyakova; L Casareto; Thomas Waldmann; G Torelli; Genoveffa Franchini
p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14(ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells.
Blood 2000;95(12):3939-44.
2000: Liljana Stevceva; Alash'Le Abimiku; Genoveffa Franchini
Targeting the mucosa: genetically engineered vaccines and mucosal immune responses.
Genes and immunity 2000;1(5):308-15.
2000: R Trovato; A Cereseto; Shigeki Takemoto; Antoine Gessain; T Watanabe; Thomas Waldmann; Genoveffa Franchini
Deletion of the p16INK4A gene in ex vivo acute adult T cell lymphoma/leukemia cells and methylation of the p16INK4A promoter in HTLV type I-infected T cell lines.
AIDS research and human retroviruses 2000;16(8):709-13.
2000: Christophe Nicot; Renaud Mahieux; Rene Opavsky; A Cereseto; Linda Wolff; John N Brady; Genoveffa Franchini
HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300.
Oncogene 2000;19(17):2155-64.
1999: ED Rivadeneira; Maria Grazia Ferrari; Ruth F Jarrett; AA Armstrong; Phillip Markham; Ted A Birkebak; Shigeki Takemoto; C Johnson-Delaney; J Pecon-Slattery; Edward A Clark; Genoveffa Franchini
A novel Epstein-Barr virus-like virus, HV(MNE), in a Macaca nemestrina with mycosis fungoides.
Blood 1999;94(6):2090-101.
1999: Vincenzo Ciminale; Lorenza Zotti; Donna M D'Agostino; Tiziana Ferro; L Casareto; Genoveffa Franchini; Paolo Bernardi; Luigi Chieco-Bianchi
Mitochondrial targeting of the p13II protein coded by the x-II ORF of human T-cell leukemia/lymphotropic virus type I (HTLV-I).
Oncogene 1999;18(31):4505-14.
1999: R Trovato; JC Mulloy; Julie M Johnson; Shigeki Takemoto; M P de Oliveira; Genoveffa Franchini
A lysine-to-arginine change found in natural alleles of the human T-cell lymphotropic/leukemia virus type 1 p12(I) protein greatly influences its stability.
Journal of virology 1999;73(8):6460-7.
1999: A Cereseto; T Kislyakova; R Washington Parks; Christophe Nicot; Genoveffa Franchini
Differential response to genotoxic stress in immortalized or transformed human T-lymphotropic virus type I-infected T-cells.
The Journal of general virology 1999;80 ( Pt 7)():1575-81.
1999: JP Slattery; Genoveffa Franchini; Antoine Gessain
Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses.
Genome research 1999;9(6):525-40.
1999: A Cereseto; R Washington Parks; ED Rivadeneira; Genoveffa Franchini
Limiting amounts of p27Kip1 correlates with constitutive activation of cyclin E-CDK2 complex in HTLV-I-transformed T-cells.
Oncogene 1999;18(15):2441-50.
1999: Michel Leno; L Carter; D J Venzon; J Romano; Phillip D Markham; K Limbach; Jim Tartaglia; E Paoletti; J Benson; Genoveffa Franchini; Marjorie Robert-Guroff
CD8+ lymphocyte antiviral activity in monkeys immunized with SIV recombinant poxvirus vaccines: potential role in vaccine efficacy.
AIDS research and human retroviruses 1999;15(5):461-70.
1998: Allen L Richards; A Giri; Diah Iskandriati; Joko Pamungkas; Annie Sie; L Rosen; R L Anthony; Genoveffa Franchini
Simian T-lymphotropic virus type I infection among wild-caught Indonesian pig-tailed macaques (Macaca nemestrina).
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;19(5):542-5.
1998: JC Mulloy; T Kislyakova; A Cereseto; L Casareto; A LoMonico; Jake R Fullen; M V Lorenzi; Andrea Cara; Christophe Nicot; Chou-Zen Giam; Genoveffa Franchini
Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain.
Journal of virology 1998;72(11):8852-60.
1998: Paola Secchiero; Lucia Bertolaso; L Casareto; Davide Gibellini; M Vitale; Kristi Bemis; A Aleotti; Silvano Capitani; Genoveffa Franchini; Robert C Gallo; giorgio zauli
Human herpesvirus 7 infection induces profound cell cycle perturbations coupled to disregulation of cdc2 and cyclin B and polyploidization of CD4(+) T cells.
Blood 1998;92(5):1685-96.
1998: JC Mulloy; TS Migone; TM Ross; N Ton; Patrick L Green; Warren J Leonard; Genoveffa Franchini
Human and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation.
Journal of virology 1998;72(5):4408-12.
1998: J Benson; Claire Chougnet; Marjorie Robert-Guroff; David Montefiori; Phillip Markham; G Shearer; Robert C Gallo; Martin Cranage; E Paoletti; K Limbach; David Venzon; Jim Tartaglia; Genoveffa Franchini
Recombinant vaccine-induced protection against the highly pathogenic simian immunodeficiency virus SIV(mac251): dependence on route of challenge exposure.
Journal of virology 1998;72(5):4170-82.
1997: Shigeki Takemoto; JC Mulloy; A Cereseto; TS Migone; Bharvin K R Patel; M Matsuoka; K Yamaguchi; K Takatsuki; S Kamihira; Jeffrey D White; Warren J Leonard; Thomas Waldmann; Genoveffa Franchini
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13897-902.
1997: Franco Lori; Robert C Gallo; Andrei Malykh; Andrea Cara; J Romano; Phillip Markham; Genoveffa Franchini
Didanosine but not high doses of hydroxyurea rescue pigtail macaque from a lethal dose of SIV(smmpbj14).
AIDS research and human retroviruses 1997;13(13):1083-8.
1997: A Cereseto; Z Berneman; I Koralnik; J Vaughn; Genoveffa Franchini; M E Klotman
Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines.
Leukemia 1997;11(6):866-70.
1997: L Digilio; A Giri; N Cho; J Slattery; Phillip Markham; Genoveffa Franchini
The simian T-lymphotropic/leukemia virus from Pan paniscus belongs to the type 2 family and infects Asian macaques.
Journal of virology 1997;71(5):3684-92.
1997: A Giri; JP Slattery; W Heneine; Antoine Gessain; ED Rivadeneira; R C Desrosiers; L Rosen; R Anthony; Joko Pamungkas; Diah Iskandriati; Allen L Richards; V Herve; H McClure; Stephen J O'Brien; Genoveffa Franchini
The tax gene sequences form two divergent monophyletic lineages corresponding to types I and II of simian and human T-cell leukemia/lymphotropic viruses.
Virology 1997;231(1):96-104.
1996: Sören Andersson; Barbro Mäkitalo; Rigmor Thorstensson; Genoveffa Franchini; Jim Tartaglia; K Limbach; E Paoletti; P Putkonen; Gunnel Biberfeld
Immunogenicity and protective efficacy of a human immunodeficiency virus type 2 recombinant canarypox (ALVAC) vaccine candidate in cynomolgus monkeys.
The Journal of infectious diseases 1996;174(5):977-85.
1996: A Cereseto; F Diella; JC Mulloy; Andrea Cara; P Michieli; R Grassmann; Genoveffa Franchini; M E Klotman
p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells.
Blood 1996;88(5):1551-60.
1996: M Myagkikh; S Alipanah; Phillip D Markham; Jim Tartaglia; E Paoletti; Robert C Gallo; Genoveffa Franchini; Marjorie Robert-Guroff
Multiple immunizations with attenuated poxvirus HIV type 2 recombinants and subunit boosts required for protection of rhesus macaques.
AIDS research and human retroviruses 1996;12(11):985-92.
1996: JC Mulloy; R W Crownley; J Fullen; Warren J Leonard; Genoveffa Franchini
The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.
Journal of virology 1996;70(6):3599-605.
1996: Genoveffa Franchini; J Benson; Robert C Gallo; E Paoletti; Jim Tartaglia
Attenuated poxvirus vectors as carriers in vaccines against human T cell leukemia-lymphoma virus type I.
AIDS research and human retroviruses 1996;12(5):407-8.
1996: A Cereseto; JC Mulloy; Genoveffa Franchini
Insights on the pathogenicity of human T-lymphotropic/leukemia virus types I and II.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;13 Suppl 1():S69-75.
1995: Genoveffa Franchini
Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection.
Blood 1995;86(10):3619-39.
1995: I J Koralnik; JC Mulloy; T Andresson; J Fullen; Genoveffa Franchini
Mapping of the intermolecular association of human T cell leukaemia/lymphotropic virus type I p12I and the vacuolar H+-ATPase 16 kDa subunit protein.
The Journal of general virology 1995;76 ( Pt 8)():1909-16.
1995: Genoveffa Franchini; Marjorie Robert-Guroff; Jim Tartaglia; A Aggarwal; Alash'Le Abimiku; J Benson; Phillip Markham; K Limbach; G Hurteau; J Fullen
Highly attenuated HIV type 2 recombinant poxviruses, but not HIV-2 recombinant Salmonella vaccines, induce long-lasting protection in rhesus macaques.
AIDS research and human retroviruses 1995;11(8):909-20.
1995: TS Migone; J X Lin; A Cereseto; JC Mulloy; John O'Shea; Genoveffa Franchini; Warren J Leonard
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
Science (New York, N.Y.) 1995;269(5220):79-81.
1995: Alash'Le Abimiku; Genoveffa Franchini; Jim Tartaglia; Kristine Aldrich; M Myagkikh; Phillip D Markham; P Chong; M Klein; M P Kieny; E Paoletti
HIV-1 recombinant poxvirus vaccine induces cross-protection against HIV-2 challenge in rhesus macaques.
Nature medicine 1995;1(4):321-9.
1995: Alash'Le Abimiku; Genoveffa Franchini; Kristine Aldrich; M Myagkikh; Phillip Markham; E Gard; Robert C Gallo; Marjorie Robert-Guroff
Humoral and cellular immune responses in rhesus macaques infected with human immunodeficiency virus type 2.
AIDS research and human retroviruses 1995;11(3):383-93.
1995: Genoveffa Franchini; H Streicher
Human T-cell leukaemia virus.
Baillière's clinical haematology 1995;8(1):131-48.
1995: Genoveffa Franchini; Jim Tartaglia; Phillip Markham; J Benson; J Fullen; M Wills; J Arp; Gregory A Dekaban; E Paoletti; Robert C Gallo
Highly attenuated HTLV type Ienv poxvirus vaccines induce protection against a cell-associated HTLV type I challenge in rabbits.
AIDS research and human retroviruses 1995;11(2):307-13.
1994: A Giri; Phillip Markham; L Digilio; G Hurteau; Robert C Gallo; Genoveffa Franchini
Isolation of a novel simian T-cell lymphotropic virus from Pan paniscus that is distantly related to the human T-cell leukemia/lymphotropic virus types I and II.
Journal of virology 1994;68(12):8392-5.
1994: Genoveffa Franchini; Marvin Reitz
Phylogenesis and genetic complexity of the nonhuman primate retroviridae.
AIDS research and human retroviruses 1994;10(9):1047-60.
1994: J Benson; Erwin Tschachler; Antoine Gessain; R Yanagihara; Robert C Gallo; Genoveffa Franchini
Cross-neutralizing antibodies against cosmopolitan and Melanesian strains of human T cell leukemia/lymphotropic virus type I in sera from inhabitants of Africa and the Solomon Islands.
AIDS research and human retroviruses 1994;10(1):91-6.
1993: Genoveffa Franchini; JC Mulloy; I J Koralnik; A Lo Monico; J J Sparkowski; T Andresson; D J Goldstein; Richard Schlegel
The human T-cell leukemia/lymphotropic virus type I p12I protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+ ATPase.
Journal of virology 1993;67(12):7701-4.
1993: F H Michaels; N Hattori; Robert C Gallo; Genoveffa Franchini
The human immunodeficiency virus type 1 (HIV-1) vif protein is located in the cytoplasm of infected cells and its effect on viral replication is equivalent in HIV-2.
AIDS research and human retroviruses 1993;9(10):1025-30.
1993: Claudia Balotta; Paolo Lusso; R Crowley; Robert C Gallo; Genoveffa Franchini
Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages.
Journal of virology 1993;67(7):4409-14.
1993: I J Koralnik; J Fullen; Genoveffa Franchini
The p12I, p13II, and p30II proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments.
Journal of virology 1993;67(4):2360-6.
1993: Antoine Gessain; Enzo Boeri; R Yanagihara; Robert C Gallo; Genoveffa Franchini
Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from melanesia: genetic and phylogenetic relationship to HTLV-I strains from other geographical regions.
Journal of virology 1993;67(2):1015-23.
1993: Enzo Boeri; Antoine Gessain; B Garin; K Kazadi; Guy de Thé; Genoveffa Franchini
Qualitative changes in the human T-cell leukemia/lymphotropic virus type I env gene sequence in the spastic versus nonspastic tropical paraparesis are not correlated with disease specificity.
AIDS research and human retroviruses 1993;9(1):1-5.
1992: I J Koralnik; J F Lemp; Robert C Gallo; Genoveffa Franchini
In vitro infection of human macrophages by human T-cell leukemia/lymphotropic virus type I (HTLV-I).
AIDS research and human retroviruses 1992;8(11):1845-9.
1992: I J Koralnik; Antoine Gessain; M E Klotman; A Lo Monico; Z N Berneman; Genoveffa Franchini
Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(18):8813-7.
1992: Franco Lori; L Hall; Paolo Lusso; M Popovic; Phillip Markham; Genoveffa Franchini; Marvin Reitz
Effect of reciprocal complementation of two defective human immunodeficiency virus type 1 (HIV-1) molecular clones on HIV-1 cell tropism and virulence.
Journal of virology 1992;66(9):5553-60.
1992: Enzo Boeri; A Giri; Flavia B Lillo; G Ferrari; Oliviero Varnier; A Ferro; S Sabbatani; W C Saxinger; Genoveffa Franchini
In vivo genetic variability of the human immunodeficiency virus type 2 V3 region.
Journal of virology 1992;66(7):4546-50.
1992: Marjorie Robert-Guroff; Kristine Aldrich; RR Muldoon; T L Stern; Geetha P Bansal; T J Matthews; Phillip D Markham; Robert C Gallo; Genoveffa Franchini
Cross-neutralization of human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus isolates.
Journal of virology 1992;66(6):3602-8.
1992: Antoine Gessain; Robert C Gallo; Genoveffa Franchini
Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations.
Journal of virology 1992;66(4):2288-95.
1992: Antoine Gessain; Enzo Boeri; K Kazadi; B Garin; J J Salaün; Robert C Gallo; Guy de Thé; Genoveffa Franchini
[HTLV-I retroviral variant in Zaire in patient with chronic neuromyelopathy. Nucleotidic sequence of the envelope gene].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1992;314(4):159-64.
1991: A Gessian; R Yanagihara; Genoveffa Franchini; R M Garruto; C L Jenkins; A B Ajdukiewicz; Robert C Gallo; D Carleton Gajdusek
Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(17):7694-8.
1991: L Marcon; F Michaels; N Hattori; K Fargnoli; Robert C Gallo; Genoveffa Franchini
Dispensable role of the human immunodeficiency virus type 2 Vpx protein in viral replication.
Journal of virology 1991;65(7):3938-42.
1991: Antoine Gessain; A Louie; O Gout; Robert C Gallo; Genoveffa Franchini
Human T-cell leukemia-lymphoma virus type I (HTLV-I) expression in fresh peripheral blood mononuclear cells from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy.
Journal of virology 1991;65(3):1628-33.
1991: L Marcon; N Hattori; Robert C Gallo; Genoveffa Franchini
A comparison of the genetic and biologic features of human and non-human immunodeficiency lentiviruses.
Antibiotics and chemotherapy 1991;43():55-68.
1990: N Hattori; F Michaels; K Fargnoli; L Marcon; Robert C Gallo; Genoveffa Franchini
The human immunodeficiency virus type 2 vpr gene is essential for productive infection of human macrophages.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):8080-4.
1990: Genoveffa Franchini; Phillip Markham; E Gard; K Fargnoli; S Keubaruwa; L Jagodzinski; Marjorie Robert-Guroff; Paolo Lusso; G Ford; F Wong-Staal
Persistent infection of rhesus macaques with a molecular clone of human immunodeficiency virus type 2: evidence of minimal genetic drift and low pathogenetic effects.
Journal of virology 1990;64(9):4462-7.
1990: Paolo Lusso; F di Marzo Veronese; Barbara Ensoli; Genoveffa Franchini; C Jemma; S E DeRocco; V S Kalyanaraman; Robert C Gallo
Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses.
Science (New York, N.Y.) 1990;247(4944):848-52.
1989: Marnix Bosch; Patricia L Earl; K Fargnoli; S Picciafuoco; F Giombini; F Wong-Staal; Genoveffa Franchini
Identification of the fusion peptide of primate immunodeficiency viruses.
Science (New York, N.Y.) 1989;244(4905):694-7.
1989: Genoveffa Franchini; K A Fargnoli; F Giombini; L Jagodzinski; A De Rossi; M Bosch; G Biberfeld; E M Fenyo; J Albert; Robert C Gallo
Molecular and biological characterization of a replication competent human immunodeficiency type 2 (HIV-2) proviral clone.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2433-7.
1989: Genoveffa Franchini
Human and non-human primate immunodeficiency viruses: genetic relatedness and phylogeny.
Current opinion in immunology 1989;1(3):513-5.
1989: Genoveffa Franchini; Marnix Bosch
Genetic relatedness of the human immunodeficiency viruses type 1 and 2 (HIV-1, HIV-2) and the simian immunodeficiency virus (SIV).
Annals of the New York Academy of Sciences 1989;554():81-7.
1989: L Marcon; Genoveffa Franchini
Genetics and biology of human retroviruses.
Bone marrow transplantation 1989;4 Suppl 1():2-4.
1988: J F Zagury; Genoveffa Franchini; Marvin Reitz; E Collalti; B Starcich; L Hall; K Fargnoli; L Jagodzinski; Hong-Guang Guo; F Laure
Genetic variability between isolates of human immunodeficiency virus (HIV) type 2 is comparable to the variability among HIV type 1.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(16):5941-5.
1988: Genoveffa Franchini; P J Kanki; Marnix Bosch; K Fargnoli; F Wong-Staal
The simian immunodeficiency virus envelope open reading frame located after the termination codon is expressed in vivo in infected animals.
AIDS research and human retroviruses 1988;4(4):251-8.
1988: Genoveffa Franchini; J R Rusche; T J O'Keeffe; F Wong-Staal
The human immunodeficiency virus type 2 (HIV-2) contains a novel gene encoding a 16 kD protein associated with mature virions.
AIDS research and human retroviruses 1988;4(4):243-50.
1988: C Gurgo; Hong-Guang Guo; Genoveffa Franchini; A Aldovini; E Collalti; K Farrell; F Wong-Staal; Robert C Gallo; Marvin Reitz
Envelope sequences of two new United States HIV-1 isolates.
Virology 1988;164(2):531-6.
1988: J W Clark; C Gurgo; Genoveffa Franchini; W N Gibbs; W Lofters; C Neuland; Dean L Mann; William Saxinger; Robert C Gallo; William A Blattner
Molecular epidemiology of HTLV-I-associated non-Hodgkin's lymphomas in Jamaica.
Cancer 1988;61(7):1477-82.
1987: Genoveffa Franchini; C Gurgo; Hong-Guang Guo; Robert C Gallo; E Collalti; K A Fargnoli; L F Hall; F Wong-Staal; Marvin Reitz
Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses.
Nature 1987;328(6130):539-43.
1987: Hong-Guang Guo; Genoveffa Franchini; E Collalti; B Beaver; C Gurgo; Robert C Gallo; F Wong-Staal; Marvin Reitz
Structure of the long terminal repeat of simian lymphotropic virus type III (African green monkey) and its relatedness to that of HIV.
AIDS research and human retroviruses 1987;3(2):177-85.
1987: Genoveffa Franchini; E Collalti; Suresh K Arya; E M Fenyö; G Biberfeld; J F Zagury; P J Kanki; F Wong-Staal; Robert C Gallo
Genetic analysis of a new subgroup of human and simian T-lymphotropic retroviruses: HTLV-IV, LAV-2, SBL-6669, and STLV-IIIAGM.
AIDS research and human retroviruses 1987;3(1):11-7.
1984: Dean L Mann; J Clark; M Clarke; Marvin Reitz; M Popovic; Genoveffa Franchini; C D Trainor; D M Strong; William A Blattner; Robert C Gallo
Identification of the human T cell lymphoma virus in B cell lines established from patients with adult T cell leukemia.
The Journal of clinical investigation 1984;74(1):56-62.
1983: B Hahn; Vittorio Manzari; S Colombini; Genoveffa Franchini; Robert C Gallo; F Wong-Staal
Common site of integration of HTLV in cells of three patients with mature T-cell leukaemia-lymphoma: a retraction.
Nature 1983;305(5932):340.
1983: B Hahn; Vittorio Manzari; S Colombini; Genoveffa Franchini; Robert C Gallo; F Wong-Staal
Common site of integration of HTLV in cells of three patients with mature T-cell leukaemia-lymphoma.
Nature 1983;303(5914):253-6.
1983: F Wong-Staal; B Hahn; Vittorio Manzari; S Colombini; Genoveffa Franchini; E P Gelmann; Robert C Gallo
A survey of human leukaemias for sequences of a human retrovirus.
Nature 1983;302(5909):626-8.
1983: Vittorio Manzari; F Wong-Staal; Genoveffa Franchini; S Colombini; E P Gelmann; S Oroszlan; S Staal; Robert C Gallo
Human T-cell leukemia-lymphoma virus (HTLV): cloning of an integrated defective provirus and flanking cellular sequences.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(6):1574-8.