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Sharron Francis

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Jennifer L Busch; Sharron H Francis; Brian P Hollett; Robyn Richie-Jannetta; Thomas M Bridges; Jackie D Corbin
Catalytic site amino acids of PKGI-alpha influence allosteric cGMP binding.
Michelle B Henesy; Richard E Honkanen; Bing Zhu; Lauren Amable; Andrea L Britain; Jackie D Corbin; Sharron H Francis; Thomas C Rich
Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells.
Sharron H Francis; Jackie D Corbin
PDE5 inhibitors: targeting erectile dysfunction in diabetics.

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2013: Jennifer L Busch; Sharron H Francis; Brian P Hollett; Robyn Richie-Jannetta; Thomas M Bridges; Jackie D Corbin
Catalytic site amino acids of PKGI-alpha influence allosteric cGMP binding.
Frontiers in bioscience (Scholar edition) 2013;5():650-60.
2012: Michelle B Henesy; Richard E Honkanen; Bing Zhu; Lauren Amable; Andrea L Britain; Jackie D Corbin; Sharron H Francis; Thomas C Rich
Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells.
PloS one 2012;7(8):e41711.
2011: Sharron H Francis; Jackie D Corbin
PDE5 inhibitors: targeting erectile dysfunction in diabetics.
Current opinion in pharmacology 2011;11(6):683-8.
2011: Jackie D Corbin; Teri-Lee Foster; Emmanuel Bessay; Jennifer Busch; Mitsi Blount; Sharron H Francis
Metal ion stimulators of PDE5 cause similar conformational changes in the enzyme as does cGMP or sildenafil.
Cellular signalling 2011;23(5):778-84.
2011: Sharron H Francis; Mitsi A Blount; Jackie D Corbin
Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions.
Physiological reviews 2011;91(2):651-90.
2011: Didem Demirbas; Ozge Ceyhan; Arlene R Wyman; F Douglas Ivey; Christina Allain; Lili Wang; Maia N Sharuk; Sharron H Francis; Charles S Hoffman
Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases.
Cellular signalling 2011;23(3):594-601.
2011: Sharron H Francis; Miles D Houslay; Marco Conti
Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action.
Handbook of experimental pharmacology 2011;(204):47-84.
2011: Sharron H Francis; SEKHAR KONJETI; Hengming Ke; Jackie D Corbin
Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds.
Handbook of experimental pharmacology 2011;(200):93-133.
2010: Sharron H Francis
The role of cGMP-dependent protein kinase in controlling cardiomyocyte cGMP.
Circulation research 2010;107(10):1164-6.
2010: Sharron H Francis; Jennifer L Busch; Jackie D Corbin; David Sibley
cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.
Pharmacological reviews 2010;62(3):525-63.
2009: Jackie D Corbin; Roya Zoraghi; Sharron H Francis
Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme.
Cellular signalling 2009;21(12):1768-74.
2009: Yu-Ting Liu; Suzanne L Matte; Jackie D Corbin; Sharron H Francis; Rick H Cote
Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitors.
The Journal of biological chemistry 2009;284(46):31541-7.
2009: James L Weeks; Jackie D Corbin; Sharron H Francis
Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond.
The Journal of pharmacology and experimental therapeutics 2009;331(1):133-41.
2009: Fabrice Vandeput; Judith Krall; Ramzi Ockaili; Fadi N Salloum; Vincent Florio; Jackie D Corbin; Sharron H Francis; Rakesh C Kukreja; Matthew A Movsesian
cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium.
The Journal of pharmacology and experimental therapeutics 2009;330(3):884-91.
2009: Nupur B Dey; Jennifer L Busch; Sharron H Francis; Jackie D Corbin; Thomas M Lincoln
Cyclic GMP specifically suppresses Type-Ialpha cGMP-dependent protein kinase expression by ubiquitination.
Cellular signalling 2009;21(6):859-66.
2009: Jennifer A Steiner; Ana Carneiro; Jane Wright; Heinrich Matthies; Harish C Prasad; Christian K Nicki; Wolfgang R Dostmann; Carrie C Buchanan; Jackie D Corbin; Sharron H Francis; Randy D Blakely
cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake.
Molecular brain 2009;2():26.
2008: Sharron H Francis; G Z Morris; Jackie D Corbin
Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function.
International journal of impotence research 2008;20(4):333-42.
2008: Emmanuel Bessay; Mitsi A Blount; Roya Zoraghi; Alfreda Beasley; Kennard A Grimes; Sharron H Francis; Jackie D Corbin
Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil.
The Journal of pharmacology and experimental therapeutics 2008;325(1):62-8.
2008: Huanchen Wang; Mengchun Ye; Howard Robinson; Sharron H Francis; Hengming Ke
Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Molecular pharmacology 2008;73(1):104-10.
2007: Roya Zoraghi; Sharron H Francis; Jackie D Corbin
Critical amino acids in phosphodiesterase-5 catalytic site that provide for high-affinity interaction with cyclic guanosine monophosphate and inhibitors.
Biochemistry 2007;46(47):13554-63.
2007: Mitsi A Blount; Roya Zoraghi; Emmanuel Bessay; Alfreda Beasley; Sharron H Francis; Jackie D Corbin
Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors.
The Journal of pharmacology and experimental therapeutics 2007;323(2):730-7.
2007: James Weeks; Roya Zoraghi; Sharron H Francis; Jackie D Corbin
N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization.
Biochemistry 2007;46(36):10353-64.
2007: Emmanuel Bessay; Roya Zoraghi; Mitsi A Blount; Kennard A Grimes; Alfreda Beasley; Sharron H Francis; Jackie D Corbin
Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil.
Frontiers in bioscience : a journal and virtual library 2007;12():1899-910.
2006: Mitsi A Blount; Roya Zoraghi; Hengming Ke; Emmanuel Bessay; Jackie D Corbin; Sharron H Francis
A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.
Molecular pharmacology 2006;70(5):1822-31.
2006: Huanchen Wang; Yudong Liu; Qing Huai; Jiwen Cai; Roya Zoraghi; Sharron H Francis; Jackie D Corbin; Howard Robinson; Zhongcheng Xin; Guiting Lin; Hengming Ke
Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development.
The Journal of biological chemistry 2006;281(30):21469-79.
2006: Robyn Richie-Jannetta; Jennifer L Busch; Kristin A Higgins; Jackie D Corbin; Sharron H Francis
Isolated regulatory domains of cGMP-dependent protein kinase Ialpha and Ibeta retain dimerization and native cGMP-binding properties and undergo isoform-specific conformational changes.
The Journal of biological chemistry 2006;281(11):6977-84.
2006: Roya Zoraghi; Jackie D Corbin; Sharron H Francis
Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity.
The Journal of biological chemistry 2006;281(9):5553-8.
2006: Stefan Kunz; Joseph A Beavo; Maximiliano A D'Angelo; Mirtha M Flawia; Sharron H Francis; Andrea Johner; Sunil Laxman; Michael Oberholzer; Ana Rascon; Yasmin Shakur; Laurent Wentzinger; Roya Zoraghi; Thomas Seebeck
Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature.
Molecular and biochemical parasitology 2006;145(1):133-5.
2005: Sharron H Francis; Jackie D Corbin
Phosphodiesterase-5 inhibition: the molecular biology of erectile function and dysfunction.
The Urologic clinics of North America 2005;32(4):419-29, vi.
2005: Jackie D Corbin; Alfreda Beasley; Mitsi A Blount; Sharron H Francis
High lung PDE5: a strong basis for treating pulmonary hypertension with PDE5 inhibitors.
Biochemical and biophysical research communications 2005;334(3):930-8.
2005: Sharron H Francis
Phosphodiesterase 11 (PDE11): is it a player in human testicular function?
International journal of impotence research 2005;17(5):467-8.
2005: Sharron H Francis; Jackie D Corbin
Sildenafil: efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction.
Expert opinion on drug metabolism & toxicology 2005;1(2):283-93.
2005: Roya Zoraghi; Emmanuel Bessay; Jackie D Corbin; Sharron H Francis
Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation.
The Journal of biological chemistry 2005;280(12):12051-63.
2005: James Weeks; Mitsi A Blount; Alfreda Beasley; Roya Zoraghi; Melissa K Thomas; SEKHAR KONJETI; Jackie D Corbin; Sharron H Francis
Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11.
Methods in molecular biology (Clifton, N.J.) 2005;307():239-62.
2005: Sharron H Francis; Mitsi A Blount; Roya Zoraghi; Jackie D Corbin
Molecular properties of mammalian proteins that interact with cGMP: protein kinases, cation channels, phosphodiesterases, and multi-drug anion transporters.
Frontiers in bioscience : a journal and virtual library 2005;10():2097-117.
2005: James Weeks; Roya Zoraghi; Alfreda Beasley; SEKHAR KONJETI; Sharron H Francis; Jackie D Corbin
High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients.
International journal of impotence research 2005;17(1):5-9.
2004: Chong-Bin Zhu; William A Hewlett; Sharron H Francis; Jackie D Corbin; Randy D Blakely
Stimulation of serotonin transport by the cyclic GMP phosphodiesterase-5 inhibitor sildenafil.
European journal of pharmacology 2004;504(1-2):1-6.
2004: Jackie D Corbin; Alfreda Beasley; Mitsi A Blount; Sharron H Francis
Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5).
Neurochemistry international 2004;45(6):859-63.
2004: Mitsi A Blount; Alfreda Beasley; Roya Zoraghi; SEKHAR KONJETI; Emmanuel Bessay; Sharron H Francis; Jackie D Corbin
Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation.
Molecular pharmacology 2004;66(1):144-52.
2004: Qing Huai; Yudong Liu; Sharron H Francis; Jackie D Corbin; Hengming Ke
Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity.
The Journal of biological chemistry 2004;279(13):13095-101.
2004: Roya Zoraghi; Jackie D Corbin; Sharron H Francis
Properties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins.
Molecular pharmacology 2004;65(2):267-78.
2004: Jun Kotera; Sharron H Francis; Kennard A Grimes; Alfreda Rouse; Mitsi A Blount; Jackie D Corbin
Allosteric sites of phosphodiesterase-5 sequester cyclic GMP.
Frontiers in bioscience : a journal and virtual library 2004;9():378-86.
2003: Robyn Richie-Jannetta; Sharron H Francis; Jackie D Corbin
Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function.
The Journal of biological chemistry 2003;278(50):50070-9.
2003: Sharron H Francis; Jackie D Corbin
Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists.
Current urology reports 2003;4(6):457-65.
2003: Jackie D Corbin; Sharron H Francis
Molecular biology and pharmacology of PDE-5-inhibitor therapy for erectile dysfunction.
Journal of andrology 2003;24(6 Suppl):S38-41.
2003: Sharron H Francis; SEKHAR KONJETI; A B Rouse; Kennard A Grimes; Jackie D Corbin
Single step isolation of sildenafil from commercially available Viagra tablets.
International journal of impotence research 2003;15(5):369-72.
2003: Jackie D Corbin; Mitsi A Blount; James Weeks; Alfreda Beasley; Karl P Kuhn; Yew S J Ho; Layla F Saidi; James H Hurley; Jun Kotera; Sharron H Francis
[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.
Molecular pharmacology 2003;63(6):1364-72.
2003: Jun Kotera; Kennard A Grimes; Jackie D Corbin; Sharron H Francis
cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5.
The Biochemical journal 2003;372(Pt 2):419-26.
2003: Michael E Wall; Sharron H Francis; Jackie D Corbin; Kennard A Grimes; Robyn Richie-Jannetta; Jun Kotera; Brian A Macdonald; Rowena R Gibson; Jill Trewhella
Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2380-5.
2002: Sharron H Francis; Emmanuel Bessay; Jun Kotera; Kennard A Grimes; Li Liu; W Joseph Thompson; Jackie D Corbin
Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity.
The Journal of biological chemistry 2002;277(49):47581-7.
2002: Jennifer L Busch; Emmanuel Bessay; Sharron H Francis; Jackie D Corbin
A conserved serine juxtaposed to the pseudosubstrate site of type I cGMP-dependent protein kinase contributes strongly to autoinhibition and lower cGMP affinity.
The Journal of biological chemistry 2002;277(37):34048-54.
2002: Jackie D Corbin; Sharron H Francis; David J Webb
Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction.
Urology 2002;60(2 Suppl 2):4-11.
2002: Jackie D Corbin; Sharron H Francis
Pharmacology of phosphodiesterase-5 inhibitors.
International journal of clinical practice 2002;56(6):453-9.
2002: Sharron H Francis; Celeste Poteet-Smith; Jennifer L Busch; Robyn Richie-Jannetta; Jackie D Corbin
Mechanisms of autoinhibition in cyclic nucleotide-dependent protein kinases.
Frontiers in bioscience : a journal and virtual library 2002;7():d580-92.
2001: V K Gopal; Sharron H Francis; Jackie D Corbin
Allosteric sites of phosphodiesterase-5 (PDE5). A potential role in negative feedback regulation of cGMP signaling in corpus cavernosum.
European journal of biochemistry / FEBS 2001;268(11):3304-12.
2001: Sharron H Francis; IV Turko; Jackie D Corbin
Cyclic nucleotide phosphodiesterases: relating structure and function.
Progress in nucleic acid research and molecular biology 2001;65():1-52.
2000: Sharron H Francis; IV Turko; Kennard A Grimes; Jackie D Corbin
Histidine-607 and histidine-643 provide important interactions for metal support of catalysis in phosphodiesterase-5.
Biochemistry 2000;39(31):9591-6.
2000: Jackie D Corbin; IV Turko; Alfreda Beasley; Sharron H Francis
Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities.
European journal of biochemistry / FEBS 2000;267(9):2760-7.
2000: jeffrey smith; R B Reed; Sharron H Francis; Kennard A Grimes; Jackie D Corbin
Distinguishing the roles of the two different cGMP-binding sites for modulating phosphorylation of exogenous substrate (heterophosphorylation) and autophosphorylation of cGMP-dependent protein kinase.
The Journal of biological chemistry 2000;275(1):154-8.
1999: T L Fink; Sharron H Francis; Alfreda Beasley; Kennard A Grimes; Jackie D Corbin
Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5).
The Journal of biological chemistry 1999;274(49):34613-20.
1999: IV Turko; Sharron H Francis; Jackie D Corbin
Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5).
The Journal of biological chemistry 1999;274(41):29038-41.
1999: Sharron H Francis; Jackie D Corbin
Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action.
Critical reviews in clinical laboratory sciences 1999;36(4):275-328.
1999: IV Turko; S A Ballard; Sharron H Francis; Jackie D Corbin
Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds.
Molecular pharmacology 1999;56(1):124-30.
1999: Jackie D Corbin; Sharron H Francis
Cyclic GMP phosphodiesterase-5: target of sildenafil.
The Journal of biological chemistry 1999;274(20):13729-32.
1998: Alexey E Granovsky; Michael Natochin; RL McEntaffer; TL Haik; Sharron H Francis; Jackie D Corbin; Nikolai O Artemyev
Probing domain functions of chimeric PDE6alpha'/PDE5 cGMP-phosphodiesterase.
The Journal of biological chemistry 1998;273(38):24485-90.
1998: DM Chu; Sharron H Francis; James W Thomas; E A Maksymovitch; M Fosler; Jackie D Corbin
Activation by autophosphorylation or cGMP binding produces a similar apparent conformational change in cGMP-dependent protein kinase.
The Journal of biological chemistry 1998;273(23):14649-56.
1998: IV Turko; Sharron H Francis; Jackie D Corbin
Hydropathic analysis and mutagenesis of the catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). cGMP versus cAMP substrate selectivity.
Biochemistry 1998;37(12):4200-5.
1998: IV Turko; Sharron H Francis; Jackie D Corbin
Potential roles of conserved amino acids in the catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase.
The Journal of biological chemistry 1998;273(11):6460-6.
1998: T A Wyatt; A J Naftilan; Sharron H Francis; Jackie D Corbin
ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells.
The American journal of physiology 1998;274(2 Pt 2):H448-55.
1998: IV Turko; Sharron H Francis; Jackie D Corbin
Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation.
The Biochemical journal 1998;329 ( Pt 3)():505-10.
1998: Jackie D Corbin; Alfreda Beasley; IV Turko; TL Haik; K A Mangum; JN Wells; Sharron H Francis; SEKHAR KONJETI
A photoaffinity probe covalently modifies the catalytic site of the cGMP-binding cGMP-specific phosphodiesterase (PDE-5).
Cell biochemistry and biophysics 1998;29(1-2):145-57.
1998: Sharron H Francis; DM Chu; M K Thomas; Alfreda Beasley; Kennard A Grimes; Jennifer L Busch; IV Turko; TL Haik; Jackie D Corbin
Ligand-induced conformational changes in cyclic nucleotide phosphodiesterases and cyclic nucleotide-dependent protein kinases.
Methods (San Diego, Calif.) 1998;14(1):81-92.
1997: DM Chu; Jackie D Corbin; Kennard A Grimes; Sharron H Francis
Activation by cyclic GMP binding causes an apparent conformational change in cGMP-dependent protein kinase.
The Journal of biological chemistry 1997;272(50):31922-8.
1997: Celeste Poteet-Smith; J B Shabb; Sharron H Francis; Jackie D Corbin
Identification of critical determinants for autoinhibition in the pseudosubstrate region of type I alpha cAMP-dependent protein kinase.
The Journal of biological chemistry 1997;272(1):379-88.
1997: Celeste Poteet-Smith; Jackie D Corbin; Sharron H Francis
The pseudosubstrate sequences alone are not sufficient for potent autoinhibition of cAMP- and cGMP-dependent protein kinases as determined by synthetic peptide analysis.
Advances in second messenger and phosphoprotein research 1997;31():219-35.
1997: R B Reed; M Sandberg; Tore Jahnsen; S M Lohmann; Sharron H Francis; Jackie D Corbin
Structural order of the slow and fast intrasubunit cGMP-binding sites of type I alpha cGMP-dependent protein kinase.
Advances in second messenger and phosphoprotein research 1997;31():205-17.
1996: IV Turko; T L Haik; Linda M McAllister-Lucas; F Burns; Sharron H Francis; Jackie D Corbin
Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterases. A putative NKXnD motif for cGMP binding.
The Journal of biological chemistry 1996;271(36):22240-4.
1996: jeffrey smith; Sharron H Francis; KA Walsh; S Kumar; Jackie D Corbin
Autophosphorylation of type Ibeta cGMP-dependent protein kinase increases basal catalytic activity and enhances allosteric activation by cGMP or cAMP.
The Journal of biological chemistry 1996;271(34):20756-62.
1996: Sharron H Francis; jeffrey smith; J L Colbran; Kennard A Grimes; KA Walsh; S Kumar; Jackie D Corbin
Arginine 75 in the pseudosubstrate sequence of type Ibeta cGMP-dependent protein kinase is critical for autoinhibition, although autophosphorylated serine 63 is outside this sequence.
The Journal of biological chemistry 1996;271(34):20748-55.
1996: R B Reed; M Sandberg; T Jahnsen; S M Lohmann; Sharron H Francis; Jackie D Corbin
Fast and slow cyclic nucleotide-dissociation sites in cAMP-dependent protein kinase are transposed in type Ibeta cGMP-dependent protein kinase.
The Journal of biological chemistry 1996;271(29):17570-5.
1995: Linda M McAllister-Lucas; T L Haik; J L Colbran; William K Sonnenburg; D Seger; IV Turko; Joseph A Beavo; Sharron H Francis; Jackie D Corbin
An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase.
The Journal of biological chemistry 1995;270(51):30671-9.
1994: Sharron H Francis; J L Colbran; Linda M McAllister-Lucas; Jackie D Corbin
Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase.
The Journal of biological chemistry 1994;269(36):22477-80.
1994: Sharron H Francis; Jackie D Corbin
Progress in understanding the mechanism and function of cyclic GMP-dependent protein kinase.
Advances in pharmacology (San Diego, Calif.) 1994;26():115-70.
1994: Sharron H Francis; Jackie D Corbin
Structure and function of cyclic nucleotide-dependent protein kinases.
Annual review of physiology 1994;56():237-72.
1993: Linda M McAllister-Lucas; William K Sonnenburg; A Kadlecek; D Seger; H L Trong; J L Colbran; M K Thomas; KA Walsh; Sharron H Francis; Jackie D Corbin
The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone.
The Journal of biological chemistry 1993;268(30):22863-73.
1993: Jackie D Corbin; C C Woodall; J L Colbran; Linda M McAllister-Lucas; SEKHAR KONJETI; Sharron H Francis
Identifying protein kinases in crude extracts that phosphorylate cyclic GMP-binding cyclic-GMP specific phosphodiesterase.
Agents and actions. Supplements 1993;43():27-33.
1992: SEKHAR KONJETI; R J Hatchett; J B Shabb; L Wolfe; Sharron H Francis; J N Wells; B Jastorff; E Butt; M M Chakinala; Jackie D Corbin
Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase.
Molecular pharmacology 1992;42(1):103-8.
1992: J L Colbran; Sharron H Francis; A B Leach; M K Thomas; H Jiang; Linda M McAllister-Lucas; Jackie D Corbin
A phenylalanine in peptide substrates provides for selectivity between cGMP- and cAMP-dependent protein kinases.
The Journal of biological chemistry 1992;267(14):9589-94.
1992: H Jiang; J L Colbran; Sharron H Francis; Jackie D Corbin
Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries.
The Journal of biological chemistry 1992;267(2):1015-9.
1992: M K Thomas; Sharron H Francis; Stephen J Beebe; T W Gettys; Jackie D Corbin
Partial mapping of cyclic nucleotide sites and studies of regulatory mechanisms of phosphodiesterases using cyclic nucleotide analogues.
Advances in second messenger and phosphoprotein research 1992;25():45-53.
1991: Sharron H Francis; L Wolfe; J D Corbin
Purification of type I alpha and type I beta isozymes and proteolyzed type I beta monomeric enzyme of cGMP-dependent protein kinase from bovine aorta.
Methods in enzymology 1991;200():332-41.
1990: M K Thomas; Sharron H Francis; Jackie D Corbin
Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.
The Journal of biological chemistry 1990;265(25):14971-8.
1990: M K Thomas; Sharron H Francis; Jackie D Corbin
Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.
The Journal of biological chemistry 1990;265(25):14964-70.
1990: Jackie D Corbin; M K Thomas; L Wolfe; J B Shabb; T A Woodford; Sharron H Francis
New insights into cGMP action.
Advances in second messenger and phosphoprotein research 1990;24():411-8.
1989: L Wolfe; Jackie D Corbin; Sharron H Francis
Characterization of a novel isozyme of cGMP-dependent protein kinase from bovine aorta.
The Journal of biological chemistry 1989;264(13):7734-41.
1989: L Wolfe; Sharron H Francis; Jackie D Corbin
Properties of a cGMP-dependent monomeric protein kinase from bovine aorta.
The Journal of biological chemistry 1989;264(7):4157-62.
1988: Sharron H Francis; B D Noblett; B W Todd; J N Wells; Jackie D Corbin
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase.
Molecular pharmacology 1988;34(4):506-17.
1988: Sharron H Francis; T A Woodford; L Wolfe; Jackie D Corbin
Types I alpha and I beta isozymes of cGMP-dependent protein kinase: alternative mRNA splicing may produce different inhibitory domains.
Second messengers and phosphoproteins 1988;12(5-6):301-10.
1988: Jackie D Corbin; Charles E Cobb; Stephen J Beebe; Daryl K Granner; S R Koch; T W Gettys; Peter F Blackmore; Sharron H Francis; J N Wells
Mechanism and function of cAMP- and cGMP-dependent protein kinases.
Advances in second messenger and phosphoprotein research 1988;21():75-86.
1988: Jackie D Corbin; T W Gettys; Peter F Blackmore; Stephen J Beebe; Sharron H Francis; D B Glass; J B Redmon; V S Sheorain; L R Landiss
Purification and assay of cAMP, cGMP, and cyclic nucleotide analogs in cells treated with cyclic nucleotide analogs.
Methods in enzymology 1988;159():74-82.
1987: L Wolfe; Sharron H Francis; L R Landiss; Jackie D Corbin
Interconvertible cGMP-free and cGMP-bound forms of cGMP-dependent protein kinase in mammalian tissues.
The Journal of biological chemistry 1987;262(35):16906-13.