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Adam Frankel

Research Profile

Chemicals & Drugs

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Methylation

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Publications

TOP 3
Adam Frankel
Inconvenient truths for PRMT6 kinetic studies.
Magnolia L Pak; Dylan Thomas; Mynol I Vhuiyan; Kristina Hüsecken; Ted M Lakowski; Adam Frankel
A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity.
Stephan A Pless; Adam Frankel; Jason D Galpin; Christopher A Ahern
Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels.

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All Publications

2012: Adam Frankel
Inconvenient truths for PRMT6 kinetic studies.
The Journal of biological chemistry 2012;287(12):9512; author reply 9513.
2011: Magnolia L Pak; Dylan Thomas; Mynol I Vhuiyan; Kristina Hüsecken; Ted M Lakowski; Adam Frankel
A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity.
Biochemistry 2011;50(38):8226-40.
2011: Stephan A Pless; Adam Frankel; Jason D Galpin; Christopher A Ahern
Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels.
Nature communications 2011;2():351.
2010: Ted M Lakowski; Peter 't Hart; Christopher A Ahern; Nathaniel I Martin; Adam Frankel
Nη-substituted arginyl peptide inhibitors of protein arginine N-methyltransferases.
ACS chemical biology 2010;5(11):1053-63.
2010: Dylan Thomas; Ted M Lakowski; Magnolia L Pak; Jenny J Kim; Adam Frankel
Förster resonance energy transfer measurements of cofactor-dependent effects on protein arginine N-methyltransferase homodimerization.
Protein science : a publication of the Protein Society 2010;19(11):2141-51.
2010: Ted M Lakowski; Cecilia Zurita-Lopez; Steven G Clarke; Adam Frankel
Approaches to measuring the activities of protein arginine N-methyltransferases.
Analytical biochemistry 2010;397(1):1-11.
2010: Ted M Lakowski; Adam Frankel
Sources of S-adenosyl-L-homocysteine background in measuring protein arginine N-methyltransferase activity using tandem mass spectrometry.
Analytical biochemistry 2010;396(1):158-60.
2009: Ted M Lakowski; Adam Frankel
Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4.
The Biochemical journal 2009;421(2):253-61.
2008: Ted M Lakowski; Adam Frankel
A kinetic study of human protein arginine N-methyltransferase 6 reveals a distributive mechanism.
The Journal of biological chemistry 2008;283(15):10015-25.
2006: Tina Branscombe Miranda; Joyce Sayegh; Adam Frankel; Jonathan E Katz; Mark Miranda; Steven Clarke
Yeast Hsl7 (histone synthetic lethal 7) catalyses the in vitro formation of omega-N(G)-monomethylarginine in calf thymus histone H2A.
The Biochemical journal 2006;395(3):563-70.
2004: Vinita Singh; Tina Branscombe Miranda; Wei Jiang; Adam Frankel; Martha E Roemer; Victoria A Robb; David H Gutmann; Harvey R Herschman; Steven Clarke; Irene Newsham
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.
Oncogene 2004;23(47):7761-71.
2004: Tina Branscombe Miranda; Mark Miranda; Adam Frankel; Steven Clarke
PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity.
The Journal of biological chemistry 2004;279(22):22902-7.
2003: Adam Frankel; Steven W Millward; Richard W Roberts
Encodamers: unnatural peptide oligomers encoded in RNA.
Chemistry & biology 2003;10(11):1043-50.
2003: Tianbing Xia; Adam Frankel; Terry T Takahashi; Jinsong Ren; Richard W Roberts
Context and conformation dictate function of a transcription antitermination switch.
Nature structural biology 2003;10(10):812-9.
2003: Adam Frankel; Shuwei Li; Shelley R Starck; Richard W Roberts
Unnatural RNA display libraries.
Current opinion in structural biology 2003;13(4):506-12.
2003: Tianbing Xia; Hans-Christian Becker; Chaozhi Wan; Adam Frankel; Richard W Roberts; Ahmed H Zewail
The RNA-protein complex: direct probing of the interfacial recognition dynamics and its correlation with biological functions.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8119-23.
2003: Adam Frankel; Richard W Roberts
In vitro selection for sense codon suppression.
RNA (New York, N.Y.) 2003;9(7):780-6.
2002: Adam Frankel; Neelu Yadav; Jaeho Lee; Tina L Branscombe; Steven Clarke; Mark T Bedford
The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity.
The Journal of biological chemistry 2002;277(5):3537-43.
2001: T L Branscombe; Adam Frankel; J H Lee; J R Cook; Z Yang ; Sidney Pestka; Steven Clarke
PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins.
The Journal of biological chemistry 2001;276(35):32971-6.
2000: Adam Frankel; S Clarke
PRMT3 is a distinct member of the protein arginine N-methyltransferase family. Conferral of substrate specificity by a zinc-finger domain.
The Journal of biological chemistry 2000;275(42):32974-82.
2000: Mark T Bedford; Adam Frankel; Michael B Yaffe; Steven Clarke; Philip Leder; S Richard
Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains.
The Journal of biological chemistry 2000;275(21):16030-6.
2000: J Tang; Adam Frankel; robert cook; Sangduk Kim; Woon Ki Paik; Kenneth R Williams; Steven Clarke; Harvey R Herschman
PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells.
The Journal of biological chemistry 2000;275(11):7723-30.
1999: Wayne W Poon; RJ Barkovich; Adam Y Hsu; Adam Frankel; Peter T Lee; Jennifer N Shepherd; D C Myles; Catherine F Clarke
Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis.
The Journal of biological chemistry 1999;274(31):21665-72.
1999: Adam Frankel; Steven Clarke
RNase treatment of yeast and mammalian cell extracts affects in vitro substrate methylation by type I protein arginine N-methyltransferases.
Biochemical and biophysical research communications 1999;259(2):391-400.