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Richard Franklin

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William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Richard A Franklin; Michelle M LaHair; Alberto M Martelli; Kristin M Stadelman; Linda S Steelman; Steven L Abrams; James A McCubrey
Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.
William H Chappell; Richard A Franklin; Michelle M LaHair; Massimo Libra; Alberto M Martelli; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Jerry Polesel; Linda Steelman; Agostino Tafuri; Renato Talamini; Steven L Abrams; Saverio Candido; Melchiorre Cervello; James A McCubrey
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.
James A McCubrey; Sanja Mijatovic; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Linda Steelman; Agostino Tafuri; Maria Clorinda Mazzarino; Steven L Abrams; Jörg Bäsecke; Saverio Candido; Melchiorre Cervello; William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Paolo Fagone; Richard A Franklin; Massimo Libra; Danijela Maksimovic-Ivanic; Grazia Malaponte; Alberto M Martelli
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.

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2013: William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Richard A Franklin; Michelle M LaHair; Alberto M Martelli; Kristin M Stadelman; Linda S Steelman; Steven L Abrams; James A McCubrey
Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.
Advances in biological regulation 2013;53(1):146-55.
2012: William H Chappell; Richard A Franklin; Michelle M LaHair; Massimo Libra; Alberto M Martelli; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Jerry Polesel; Linda Steelman; Agostino Tafuri; Renato Talamini; Steven L Abrams; Saverio Candido; Melchiorre Cervello; James A McCubrey
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.
Cell cycle (Georgetown, Tex.) 2012;11(23):4447-61.
2012: James A McCubrey; Sanja Mijatovic; Michele Milella; Giuseppe Montalto; Ferdinando Nicoletti; Linda Steelman; Agostino Tafuri; Maria Clorinda Mazzarino; Steven L Abrams; Jörg Bäsecke; Saverio Candido; Melchiorre Cervello; William H Chappell; Francesca Chiarini; Lucio Cocco; Camilla Evangelisti; Paolo Fagone; Richard A Franklin; Massimo Libra; Danijela Maksimovic-Ivanic; Grazia Malaponte; Alberto M Martelli
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.
Oncotarget 2012;3(10):1068-111.
2012: James A McCubrey; Kazuo Umezawa; Steven L Abrams; William H Chappell; Lucio Cocco; Richard A Franklin; Alberto M Martelli; Linda S Steelman
Novel approaches to target cancer initiating cells-eliminating the root of the cancer.
Advances in biological regulation 2012;52(1):249-64.
2011: Linda Steelman; Franca Stivala; Ellis W T Wong; Patrick Navolanic; Ferdinando Nicoletti; Steven L Abrams; William H Chappell; Lucio Cocco; Lyudmyla B Drobot; Richard A Franklin; Massimo Libra; Alberto M Martelli; James A McCubrey
Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells.
Cell cycle (Georgetown, Tex.) 2011;10(17):3003-15.
2011: Melissa L Sokolosky; Kristin M Stadelman; Linda Steelman; Franca Stivala; Steven L Abrams; William H Chappell; Lyudmyla B Drobot; Richard A Franklin; Massimo Libra; Alberto M Martelli; Ferdinando Nicoletti; James A McCubrey
Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy.
Oncotarget 2011;2(7):538-50.
2011: Linda Steelman; Franca Stivala; F Nicoletti; P Ruvolo; V Ruvolo; Steven L Abrams; Jörg Bäsecke; W Chappell; Marco Donia; Camilla Evangelisti; P Fagone; Richard A Franklin; C R Kempf; Massimo Libra; Alberto M Martelli; James A McCubrey
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
Leukemia 2011;25(7):1080-94.
2011: William H Chappell; Linda Steelman; Jacquelyn M Long; Ruth C Kempf; Steven L Abrams; Richard A Franklin; Jörg Bäsecke; Franca Stivala; Marco Donia; Paolo Fagone; Graziella Malaponte; Maria C Mazzarino; Ferdinando Nicoletti; Massimo Libra; Danijela Maksimovic-Ivanic; Sanja Mijatovic; Giuseppe Montalto; Melchiorre Cervello; Piotr Laidler; Michele Milella; Agostino Tafuri; Antonio Bonati; Camilla Evangelisti; Lucio Cocco; Alberto M Martelli; James A McCubrey
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.
Oncotarget 2011;2(3):135-64.
2011: James A McCubrey; William H Chappell; Steven L Abrams; Richard A Franklin; Jacquelyn M Long; Jennifer A Sattler; C Ruth Kempf; Piotr Laidler; Linda Steelman
Targeting the cancer initiating cell: the Achilles' heel of cancer.
Advances in enzyme regulation 2011;51(1):152-62.
2009: Richard A Franklin; James A McCubrey
The involvement of CaM-KII in insulin induced cell proliferation.
Cell cycle (Georgetown, Tex.) 2009;8(13):1979.
2008: Linda Steelman; Patrick M Navolanic; M L Sokolosky; J R Taylor; B D Lehmann; William H Chappell; Steven L Abrams; E W T Wong; K M Stadelman; David M Terrian; N R Leslie; A M Martelli; Franca Stivala; Massimo Libra; Richard A Franklin; James A McCubrey
Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.
Oncogene 2008;27(29):4086-95.
2008: James A McCubrey; Jörg Bäsecke; Melchiorre Cervello; Alberto M Martelli; Richard A Franklin
GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity.
Cancer biology & therapy 2008;7(7):1079.
2008: Richard A Franklin; James A McCubrey
A multipronged approach to prostate cancer.
Cancer biology & therapy 2008;7(4):594-5.
2008: Linda Steelman; Patrick M Navolanic; Richard A Franklin; Antonio Bonati; Massimo Libra; Franca Stivala; Alberto M Martelli; James A McCubrey
Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review).
Molecular medicine reports 2008;1(2):139-60.
2008: James A McCubrey; Melissa L Sokolosky; Brian D Lehmann; Jackson R Taylor; Patrick M Navolanic; William H Chappell; Steven L Abrams; Kristin M Stadelman; Ellis W T Wong; Negin Misaghian; Stefan Horn; Jörg Bäsecke; Massimo Libra; Franca Stivala; Giovanni Ligresti; Agostino Tafuri; Michele Milella; Marek Zarzycki; Andrzej Dzugaj; Francesca Chiarini; Camilla Evangelisti; Alberto M Martelli; David M Terrian; Richard A Franklin; Linda Steelman
Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.
Advances in enzyme regulation 2008;48():113-35.
2007: James A McCubrey; Linda Steelman; William H Chappell; Steven L Abrams; Ellis W T Wong; Fumin Chang; Brian D Lehmann; David M Terrian; Michele Milella; Agostino Tafuri; Franca Stivala; Massimo Libra; Jorg Basecke; Camilla Evangelisti; Alberto M Martelli; Richard A Franklin
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.
Biochimica et biophysica acta 2007;1773(8):1263-84.
2007: James A McCubrey; Linda Steelman; Richard A Franklin; Steven L Abrams; William H Chappell; Ellis W T Wong; Brian D Lehmann; David M Terrian; Jorg Basecke; Franca Stivala; Massimo Libra; Camilla Evangelisti; Alberto M Martelli
Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.
Advances in enzyme regulation 2007;47():64-103.
2007: Richard A Franklin; James A McCubrey
Polyphenols in breast cancer treatment.
Cancer biology & therapy 2007;6(1):62-3.
2006: Ruben Garcia; Richard A Franklin; James A McCubrey
EGF induces cell motility and multi-drug resistance gene expression in breast cancer cells.
Cell cycle (Georgetown, Tex.) 2006;5(23):2820-6.
2006: Richard A Franklin; Oswaldo Rodriguez-Mora; Michelle M LaHair; James A McCubrey
Activation of the calcium/calmodulin-dependent protein kinases as a consequence of oxidative stress.
Antioxidants & redox signaling 2006;8(9-10):1807-17.
2006: James A McCubrey; Michelle M LaHair; Richard A Franklin
Reactive oxygen species-induced activation of the MAP kinase signaling pathways.
Antioxidants & redox signaling 2006;8(9-10):1775-89.
2006: Michelle M LaHair; Christopher J Howe; Oswaldo Rodriguez-Mora; James A McCubrey; Richard A Franklin
Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.
Antioxidants & redox signaling 2006;8(9-10):1749-56.
2006: Ruben Garcia; Richard A Franklin; James A McCubrey
Cell death of MCF-7 human breast cancer cells induced by EGFR activation in the absence of other growth factors.
Cell cycle (Georgetown, Tex.) 2006;5(16):1840-6.
2006: Oswaldo Rodriguez-Mora; Michelle M LaHair; Mark J Evans; Charles J Kovacs; Ron R Allison; Claudio Sibata; Kawana S White; James A McCubrey; Richard A Franklin
Inhibition of the CaM-kinases augments cell death in response to oxygen radicals and oxygen radical inducing cancer therapies in MCF-7 human breast cancer cells.
Cancer biology & therapy 2006;5(8):1022-30.
2006: James A McCubrey; Michelle M LaHair; Richard A Franklin
OSU-03012 in the treatment of glioblastoma.
Molecular pharmacology 2006;70(2):437-9.
2006: James A McCubrey; Linda Steelman; Steven L Abrams; John Lee; Fumin Chang; Fred E Bertrand; Patrick M Navolanic; David M Terrian; Richard A Franklin; Antonio B D'Assoro; Jeffrey Salisbury; Maria Clorinda Mazzarino; Franca Stivala; Massimo Libra
Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.
Advances in enzyme regulation 2006;46():249-79.
2005: Richard A Franklin; Massimo Libra; Franca Stivala; James A McCubrey
Two targets are better than one. Promising combination therapy to treat breast cancer.
Cancer biology & therapy 2005;4(11):1190-1.
2005: John G Shelton; Linda Steelman; Steven L Abrams; Fred E Bertrand; Richard A Franklin; Martin McMahon; James A McCubrey
The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?
Expert opinion on therapeutic targets 2005;9(5):1009-30.
2005: Oswaldo Rodriguez-Mora; Michelle M LaHair; Christopher J Howe; James A McCubrey; Richard A Franklin
Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy.
Expert opinion on therapeutic targets 2005;9(4):791-808.
2005: Oswaldo Rodriguez-Mora; Michelle M LaHair; James A McCubrey; Richard A Franklin
Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.
Cancer research 2005;65(12):5408-16.
2005: Oswaldo Rodriguez-Mora; Christopher J Howe; Michelle M LaHair; James A McCubrey; Richard A Franklin
Inhibition of CREB transcriptional activity in human T lymphocytes by oxidative stress.
Free radical biology & medicine 2005;38(12):1653-61.
2005: John G Shelton; Linda Steelman; Steven L Abrams; Edmund R White; Shaw M Akula; Richard A Franklin; Fred E Bertrand; Martin McMahon; James A McCubrey
Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines.
Cell cycle (Georgetown, Tex.) 2005;4(6):822-30.
2005: John G Shelton; Linda Steelman; Steven L Abrams; Edmund R White; Shaw M Akula; Fred E Bertrand; Richard A Franklin; James A McCubrey
Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line.
Cell cycle (Georgetown, Tex.) 2005;4(6):818-21.
2004: Christopher J Howe; Michelle M LaHair; James A McCubrey; Richard A Franklin
Redox regulation of the calcium/calmodulin-dependent protein kinases.
The Journal of biological chemistry 2004;279(43):44573-81.
2004: James A McCubrey; John G Shelton; Linda Steelman; Richard A Franklin; Thazepadath Sreevalsan; Martin McMahon
Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.
Oncogene 2004;23(47):7810-20.
2004: Linda Steelman; Steven C Pohnert; John G Shelton; Richard A Franklin; Fred E Bertrand; James A McCubrey
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
Leukemia 2004;18(2):189-218.
2004: John G Shelton; Fumin Chang; John Lee; Richard A Franklin; Linda Steelman; James A McCubrey
B-raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells.
Cell cycle (Georgetown, Tex.) 2004;3(2):189-96.
2003: John G Shelton; Phillip W Moye; Linda Steelman; William L Blalock; John Lee; Richard A Franklin; Martin McMahon; James A McCubrey
Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.
Leukemia 2003;17(9):1765-82.
2003: Christopher J Howe; Michelle M LaHair; Penni J Robinson; Oswaldo Rodriguez-Mora; James A McCubrey; Richard A Franklin
Models of anergy in the human Jurkat T cell line.
Assay and drug development technologies 2003;1(4):537-44.
2003: Oswaldo Rodriguez-Mora; Richard A Franklin; James A McCubrey
A new hope for treatment of glioblastomas.
Cancer biology & therapy 2003;2(4):354-5.
2003: Fumin Chang; Linda Steelman; John Lee; John G Shelton; Patrick M Navolanic; William L Blalock; Richard A Franklin; James A McCubrey
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.
Leukemia 2003;17(7):1263-93.
2003: William L Blalock; Patrick M Navolanic; Linda Steelman; John G Shelton; Phillip W Moye; John Lee; Richard A Franklin; A Mirza; Martin McMahon; Martyn K White; James A McCubrey
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
Leukemia 2003;17(6):1058-67.
2003: John G Shelton; Linda Steelman; John Lee; Steven L Knapp; William L Blalock; Phillip W Moye; Richard A Franklin; Steven C Pohnert; Amer M Mirza; Martin McMahon; James A McCubrey
Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.
Oncogene 2003;22(16):2478-92.
2003: Fumin Chang; John Lee; Patrick M Navolanic; Linda Steelman; John G Shelton; William L Blalock; Richard A Franklin; James A McCubrey
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.
Leukemia 2003;17(3):590-603.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Elucidation of signal transduction pathways by retroviral infection of cells with modified oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;218():221-52.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Elucidation of signal transduction pathways by transfection of cells with modified oncogenes.
Methods in molecular biology (Clifton, N.J.) 2003;218():203-20.
2003: Linda Steelman; William L Blalock; Xiao-Yang Wang; Phillip W Moye; John Lee; John G Shelton; Patrick M Navolanic; Julianne M Davis; Steven L Knapp; Richard A Franklin; Martyn K White; James A McCubrey
Fibroblastic, hematopoietic, and hormone responsive epithelial cell lines and culture conditions for elucidation of signal transduction and drug resistance pathways by gene transfer.
Methods in molecular biology (Clifton, N.J.) 2003;218():185-201.
2003: Richard A Franklin
The use of the yeast two-hybrid system to measure protein-protein interactions that occur following oxidative stress.
Methods in molecular biology (Clifton, N.J.) 2003;218():47-57.
2002: Christopher J Howe; Michelle M LaHair; Jill A Maxwell; John Lee; Penni J Robinson; Oswaldo Rodriguez-Mora; James A McCubrey; Richard A Franklin
Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced Ikappa B phosphorylation in human T lymphocytes.
The Journal of biological chemistry 2002;277(34):30469-76.
2001: Caroline R Weinstein-Oppenheimer; C F Henríquez-Roldán; Julianne M Davis; Patrick M Navolanic; Oussama A Saleh; Linda Steelman; Richard A Franklin; P J Robinson; Martin McMahon; James A McCubrey
Role of the Raf signal transduction cascade in the in vitro resistance to the anticancer drug doxorubicin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2898-907.
2001: James A McCubrey; William L Blalock; Oussama A Saleh; M Pearce; Carlo Burrows; Linda Steelman; John Lee; Richard A Franklin; Stephanie M Oberhaus; Phillip W Moye; Parul D Doshi; John P McKearn
Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells.
Leukemia 2001;15(8):1203-16.
2001: William L Blalock; M Pearce; Fumin Chang; John Lee; Steven C Pohnert; Carlo Burrows; Linda Steelman; Richard A Franklin; Martin McMahon; James A McCubrey
Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells.
Leukemia 2001;15(5):794-807.
2001: James A McCubrey; John Lee; Linda Steelman; William L Blalock; Phillip W Moye; Fumin Chang; M Pearce; John G Shelton; Martyn K White; Richard A Franklin; Steven C Pohnert
Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells.
Cancer detection and prevention 2001;25(4):375-93.
2001: James A McCubrey; Linda Steelman; William L Blalock; John Lee; Phillip W Moye; Fumin Chang; M Pearce; John G Shelton; Martyn K White; Richard A Franklin; Steven C Pohnert
Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.
Advances in enzyme regulation 2001;41():289-323.
2001: Richard A Franklin; PA Atherfold; Penni J Robinson; D Bonner
Regulation of Pyk2 expression by p56(Lck) in Jurkat T lymphocytes.
Cellular signalling 2001;13(1):65-9.
2000: Richard A Franklin; James A McCubrey
Kinases: positive and negative regulators of apoptosis.
Leukemia 2000;14(12):2019-34.
2000: E A Martin; P J Robinson; Richard A Franklin
Oxidative stress regulates the interaction of p16 with Cdk4.
Biochemical and biophysical research communications 2000;275(3):764-7.
2000: Richard A Franklin; PA Atherfold; James A McCubrey
Calcium-induced ERK activation in human T lymphocytes occurs via p56(Lck) and CaM-kinase.
Molecular immunology 2000;37(11):675-83.
2000: Phillip W Moye; William L Blalock; PE Hoyle; Fumin Chang; Richard A Franklin; Caroline R Weinstein-Oppenheimer; M Pearce; Linda Steelman; Martin McMahon; James A McCubrey
Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.
Leukemia 2000;14(6):1060-79.
2000: PE Hoyle; Phillip W Moye; Linda Steelman; William L Blalock; Richard A Franklin; M Pearce; Holly Cherwinski; E Bosch; Martin McMahon; James A McCubrey
Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism.
Leukemia 2000;14(4):642-56.
2000: William L Blalock; M Pearce; Linda Steelman; Richard A Franklin; S A McCarthy; Holly Cherwinski; Martin McMahon; James A McCubrey
A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.
Oncogene 2000;19(4):526-36.
1999: William L Blalock; Caroline R Weinstein-Oppenheimer; Fumin Chang; PE Hoyle; Xiao-Yang Wang; P A Algate; Richard A Franklin; Stephanie M Oberhaus; Linda Steelman; James A McCubrey
Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs.
Leukemia 1999;13(8):1109-66.
1999: Richard A Franklin; A Mcleod; Penni J Robinson
Calcium-induced p56(Lck) phosphorylation in human T lymphocytes via calmodulin dependent kinase.
Biochemical and biophysical research communications 1999;259(2):283-6.
1999: PA Atherfold; MS Norris; Penni J Robinson; E W Gelfand; Richard A Franklin
Calcium-induced ERK activation in human T lymphocytes.
Molecular immunology 1999;36(8):543-9.
1998: James A McCubrey; Linda Steelman; PE Hoyle; William L Blalock; Caroline R Weinstein-Oppenheimer; Richard A Franklin; Holly Cherwinski; E Bosch; Martin McMahon
Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells.
Leukemia 1998;12(12):1903-29.