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Renty Franklin

Research Profile

Anatomy

Chemicals & Drugs

Disorders

Prostatic Neoplasms

Living Beings

Phenomena

Oxidation-Reduction

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Kinetics

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Publications

TOP 3
Leslie C Costello; Mohamed M Desouki; Jing Zou; Renty B Franklin
Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma.
Leslie C Costello; Renty B Franklin
The genetic/metabolic transformation concept of carcinogenesis.
Renty B Franklin; Nadar N Hanna; Leslie A Johnson; Bernard A Levy; Jing Zou; Omar Bagasra; Mohamed M Desouki; Leslie C Costello
ZIP14 zinc transporter downregulation and zinc depletion in the development and progression of hepatocellular cancer.

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All Publications

2012: Leslie C Costello; Mohamed M Desouki; Jing Zou; Renty B Franklin
Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma.
Journal of gastrointestinal cancer 2012;43(4):570-8.
2012: Leslie C Costello; Renty B Franklin
The genetic/metabolic transformation concept of carcinogenesis.
Cancer metastasis reviews 2012;31(1-2):123-30.
2012: Renty B Franklin; Nadar N Hanna; Leslie A Johnson; Bernard A Levy; Jing Zou; Omar Bagasra; Mohamed M Desouki; Leslie C Costello
ZIP14 zinc transporter downregulation and zinc depletion in the development and progression of hepatocellular cancer.
Journal of gastrointestinal cancer 2012;43(2):249-57.
2012: Leslie C Costello; Renty B Franklin
Cytotoxic/tumor suppressor role of zinc for the treatment of cancer: an enigma and an opportunity.
Expert review of anticancer therapy 2012;12(1):121-8.
2011: Leslie C Costello; Pei Feng; Renty B Franklin; Mark G Swanson; Jing Zou; Robert Bok; John Kurhanewicz
Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model.
Cancer biology & therapy 2011;12(12):1078-84.
2011: Leslie C Costello; Renty B Franklin
Integration of molecular genetics and proteomics with cell metabolism: how to proceed; how not to proceed!
Gene 2011;486(1-2):88-93.
2011: Leslie C Costello; Mohamed M Desouki; Omar Bagasra; Nadar N Hanna; Leslie A Johnson; Bernard A Levy; Jing Zou; Renty B Franklin
Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma.
Cancer biology & therapy 2011;12(4):297-303.
2011: Leslie C Costello; Catherine C Fenselau; Renty B Franklin
Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells.
Journal of inorganic biochemistry 2011;105(5):589-99.
2011: Leslie C Costello; Renty B Franklin
Zinc is decreased in prostate cancer: an established relationship of prostate cancer!
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(1):3-8.
2010: Beatrice Milon; Anthony Agyapong; Roderick Bautista; Leslie C Costello; Renty B Franklin
Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells.
The Prostate 2010;70(3):288-96.
2009: Shu-Fei Lin; Hua Wei; Dennis L Maeder; Renty B Franklin; Pei Feng
Profiling of zinc-altered gene expression in human prostate normal vs. cancer cells: a time course study.
The Journal of nutritional biochemistry 2009;20(12):1000-12.
2009: Renty B Franklin; Leslie C Costello
Re: Vitamin and mineral use and risk of prostate cancer: the case-control surveillance: Zhang et al. Cancer Causes Control. 2008 Dec 18 [Epub ahead of print].
Cancer causes & control : CCC 2009;20(8):1529-31; author reply 1533.
2009: Renty B Franklin; Leslie C Costello
The important role of the apoptotic effects of zinc in the development of cancers.
Journal of cellular biochemistry 2009;106(5):750-7.
2009: Leslie C Costello; Renty B Franklin
Prostatic fluid electrolyte composition for the screening of prostate cancer: a potential solution to a major problem.
Prostate cancer and prostatic diseases 2009;12(1):17-24.
2008: Pei Feng; Tieluo Li; Zhixin Guan; Renty B Franklin; Leslie C Costello
The involvement of Bax in zinc-induced mitochondrial apoptogenesis in malignant prostate cells.
Molecular cancer 2008;7():25.
2008: Hua Wei; Mohamed M Desouki; Shufei Lin; Dakai Xiao; Renty B Franklin; Pei Feng
Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues.
Molecular cancer 2008;7():7.
2007: Leslie C Costello; Renty B Franklin
Re: Silvano Gallus, Roberto Foschi, Eva Negri et al. Dietary zinc and prostate cancer risk: a case-control study from Italy. Eur urol 2007;52:1052-7.
European urology 2007;52(4):1262-3; author reply 1263-4.
2007: B K Matheson; J L Adams; Jing Zou; R Patel; Renty B Franklin
Effect of metabolic inhibitors on ATP and citrate content in PC3 prostate cancer cells.
The Prostate 2007;67(11):1211-8.
2007: Renty B Franklin; Leslie C Costello
Zinc as an anti-tumor agent in prostate cancer and in other cancers.
Archives of biochemistry and biophysics 2007;463(2):211-7.
2007: Mohamed M Desouki; Joseph Geradts; Beatrice Milon; Renty B Franklin; Leslie C Costello
hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.
Molecular cancer 2007;6():37.
2006: Beatrice Milon; Qin Wu; Jing Zou; Leslie C Costello; Renty B Franklin
Histidine residues in the region between transmembrane domains III and IV of hZip1 are required for zinc transport across the plasma membrane in PC-3 cells.
Biochimica et biophysica acta 2006;1758(10):1696-701.
2006: Ziqiang Yu; Leslie C Costello; Pei Feng; Renty B Franklin
Characterization of the mitochondrial aconitase promoter and the identification of transcription factor binding.
The Prostate 2006;66(10):1061-9.
2006: Zhihui Tang; Surasri Nandan Sahu; Mohammed A Khadeer; Guang Bai; Renty B Franklin; Anandarup Gupta
Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells.
Bone 2006;38(2):181-98.
2006: Leslie C Costello; Renty B Franklin
Tumor cell metabolism: the marriage of molecular genetics and proteomics with cellular intermediary metabolism; proceed with caution!
Molecular cancer 2006;5():59.
2006: Leslie C Costello; Renty B Franklin
The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots.
Molecular cancer 2006;5():17.
2006: Keshav K Singh; Mohamed M Desouki; Renty B Franklin; Leslie C Costello
Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues.
Molecular cancer 2006;5():14.
2006: Renty B Franklin; Jing Zou; Ziqiang Yu; Leslie C Costello
EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity L-aspartate transporter; and is regulated by prolactin and testosterone.
BMC biochemistry 2006;7():10.
2006: Gabriel D Dakubo; Ryan L Parr; Leslie C Costello; Renty B Franklin; Robert E Thayer
Altered metabolism and mitochondrial genome in prostate cancer.
Journal of clinical pathology 2006;59(1):10-6.
2005: Leslie C Costello; Renty B Franklin
'Why do tumour cells glycolyse?': from glycolysis through citrate to lipogenesis.
Molecular and cellular biochemistry 2005;280(1-2):1-8.
2005: Leslie C Costello; Renty B Franklin; Pei Feng; Ming Tan; Omar Bagasra
Zinc and prostate cancer: a critical scientific, medical, and public interest issue (United States).
Cancer causes & control : CCC 2005;16(8):901-15.
2005: Wenke Feng; Jian Cai; William M Pierce; Renty B Franklin; Wolfgang Maret; Frederick Benz; Y James Kang
Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts.
Biochemical and biophysical research communications 2005;332(3):853-8.
2005: Leslie C Costello; Renty B Franklin; Pei Feng
Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer.
Mitochondrion 2005;5(3):143-53.
2005: Renty B Franklin; Pei Feng; Beatrice Milon; Mohamed M Desouki; Keshav K Singh; Andre A. Kajdacsy-Balla; Omar Bagasra; Leslie C Costello
hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer.
Molecular cancer 2005;4():32.
2005: Renty B Franklin; Beatrice Milon; Pei Feng; Leslie C Costello
Zinc and zinc transporters in normal prostate and the pathogenesis of prostate cancer.
Frontiers in bioscience : a journal and virtual library 2005;10():2230-9.
2004: Boone Kukoyi; Leslie C Costello; Renty B Franklin
The effect of exogenous zinc ions on the pattern of oxygen consumption of the hepatic mitochondria of albino rats.
African journal of medicine and medical sciences 2004;33(4):361-3.
2004: Leslie C Costello; Zhixin Guan; Boone Kukoyi; Pei Feng; Renty B Franklin
Terminal oxidation and the effects of zinc in prostate versus liver mitochondria.
Mitochondrion 2004;4(4):331-8.
2004: Leslie C Costello; Zhixin Guan; Renty B Franklin; Pei Feng
Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria.
Journal of inorganic biochemistry 2004;98(4):664-6.
2004: Leslie C Costello; Renty B Franklin; Pei Feng; Ming Tan
Re: Zinc supplement use and risk of prostate cancer.
Journal of the National Cancer Institute 2004;96(3):239-40; author reply 240-1.
2004: Leslie C Costello; Pei Feng; Beatrice Milon; Ming Tan; Renty B Franklin
Role of zinc in the pathogenesis and treatment of prostate cancer: critical issues to resolve.
Prostate cancer and prostatic diseases 2004;7(2):111-7.
2003: Pei Feng; Tie-Luo Li; Zhi-Xin Guan; Renty B Franklin; Leslie C Costello
Effect of zinc on prostatic tumorigenicity in nude mice.
Annals of the New York Academy of Sciences 2003;1010():316-20.
2003: Zhixin Guan; Boone Kukoyi; Pei Feng; M Claire Kennedy; Renty B Franklin; Leslie C Costello
Kinetic identification of a mitochondrial zinc uptake transport process in prostate cells.
Journal of inorganic biochemistry 2003;97(2):199-206.
2003: Renty B Franklin; JINFANG MA; J Zou; Zhixin Guan; Boone Kukoyi; Pei Feng; Leslie C Costello
Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.
Journal of inorganic biochemistry 2003;96(2-3):435-42.
2002: Pei Feng; Tie-Luo Li; Zhi-Xin Guan; Renty B Franklin; Leslie C Costello
Direct effect of zinc on mitochondrial apoptogenesis in prostate cells.
The Prostate 2002;52(4):311-8.
2002: Leslie C Costello; Renty B Franklin
Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(8):417-24.
2000: Renty B Franklin; J Zou; JINFANG MA; Leslie C Costello
Protein kinase C alpha, epsilon and AP-1 mediate prolactin regulation of mitochondrial aspartate aminotransferase expression in the rat lateral prostate.
Molecular and cellular endocrinology 2000;170(1-2):153-61.
2000: Leslie C Costello; Renty B Franklin
The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of prostate malignancy.
Oncology 2000;59(4):269-82.
2000: Leslie C Costello; Y Liu; Jing Zou; Renty B Franklin
Mitochondrial aconitase gene expression is regulated by testosterone and prolactin in prostate epithelial cells .
The Prostate 2000;42(3):196-202.
2000: Leslie C Costello; Yewei Liu; J Zou; Renty B Franklin
The pyruvate dehydrogenase E1 alpha gene is testosterone and prolactin regulated in prostate epithelial cells.
Endocrine research 2000;26(1):23-39.
2000: Leslie C Costello; Renty B Franklin; Y Liu; M Claire Kennedy
Zinc causes a shift toward citrate at equilibrium of the m-aconitase reaction of prostate mitochondria.
Journal of inorganic biochemistry 2000;78(2):161-5.
2000: Pei Feng; JY Liang; Tie-Luo Li; Zhi-Xin Guan; Jing Zou; Renty B Franklin; Leslie C Costello
Zinc induces mitochondria apoptogenesis in prostate cells.
Molecular urology 2000;4(1):31-6.
1999: JY Liang; Yewei Liu; Jing Zou; Renty B Franklin; Leslie C Costello; Pei Feng
Inhibitory effect of zinc on human prostatic carcinoma cell growth.
The Prostate 1999;40(3):200-7.
1999: Leslie C Costello; Y Liu; J Zou; Renty B Franklin
Evidence for a zinc uptake transporter in human prostate cancer cells which is regulated by prolactin and testosterone.
The Journal of biological chemistry 1999;274(25):17499-504.
1999: Leslie C Costello; Renty B Franklin; P Narayan
Citrate in the diagnosis of prostate cancer.
The Prostate 1999;38(3):237-45.
1998: Leslie C Costello; Renty B Franklin
Novel role of zinc in the regulation of prostate citrate metabolism and its implications in prostate cancer.
The Prostate 1998;35(4):285-96.
1997: Leslie C Costello; Y Liu; Renty B Franklin; M Claire Kennedy
Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells.
The Journal of biological chemistry 1997;272(46):28875-81.
1997: Leslie C Costello; Renty B Franklin
Citrate metabolism of normal and malignant prostate epithelial cells.
Urology 1997;50(1):3-12.
1997: Renty B Franklin; J Zou; E Gorski; Y H Yang; Leslie C Costello
Prolactin regulation of mitochondrial aspartate aminotransferase and protein kinase C in human prostate cancer cells.
Molecular and cellular endocrinology 1997;127(1):19-25.
1997: Y Liu; Renty B Franklin; Leslie C Costello
Prolactin and testosterone regulation of mitochondrial zinc in prostate epithelial cells.
The Prostate 1997;30(1):26-32.
1996: Leslie C Costello; Y Liu; Renty B Franklin
Testosterone and prolactin stimulation of mitochondrial aconitase in pig prostate epithelial cells.
Urology 1996;48(4):654-9.
1996: Y Liu; Leslie C Costello; Renty B Franklin
Prolactin specifically regulates citrate oxidation and m-aconitase of rat prostate epithelial cells.
Metabolism: clinical and experimental 1996;45(4):442-9.
1995: Renty B Franklin; Horng-Heng Juang; Jing Zou; Leslie C Costello
Regulation of citrate metabolism by androgen in the LNCaP human prostate carcinoma cell line.
Endocrine 1995;3(8):603-7.
1995: Leslie C Costello; Y Liu; Renty B Franklin
Testosterone stimulates the biosynthesis of m-aconitase and citrate oxidation in prostate epithelial cells.
Molecular and cellular endocrinology 1995;112(1):45-51.
1995: Horng-Heng Juang; Leslie C Costello; Renty B Franklin
Androgen modulation of multiple transcription start sites of the mitochondrial aspartate aminotransferase gene in rat prostate.
The Journal of biological chemistry 1995;270(21):12629-34.
1995: Leslie C Costello; Y Liu; Renty B Franklin
Prolactin specifically increases pyruvate dehydrogenase E1 alpha in rat lateral prostate epithelial cells.
The Prostate 1995;26(4):189-93.
1994: Leslie C Costello; Renty B Franklin; W K Ashe
Black physiologists--where are they?
The Physiologist 1994;37(6):284-6.
1994: Leslie C Costello; Renty B Franklin
Bioenergetic theory of prostate malignancy.
The Prostate 1994;25(3):162-6.
1994: Leslie C Costello; Renty B Franklin
Effect of prolactin on the prostate.
The Prostate 1994;24(3):162-6.
1993: Leslie C Costello; Lixing Lao; Renty B Franklin
Citrate modulation of high-affinity aspartate transport in prostate epithelial cells.
Cellular and molecular biology (Noisy-le-Grand, France) 1993;39(5):515-24.
1993: Leslie C Costello; Renty B Franklin
Testosterone regulates pyruvate dehydrogenase activity of prostate mitochondria.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1993;25(5):268-70.
1993: Lixing Lao; Renty B Franklin; Leslie C Costello
High-affinity L-aspartate transporter in prostate epithelial cells that is regulated by testosterone.
The Prostate 1993;22(1):53-63.
1993: K Qian; Renty B Franklin; Leslie C Costello
Testosterone regulates mitochondrial aspartate aminotransferase gene expression and mRNA stability in prostate.
The Journal of steroid biochemistry and molecular biology 1993;44(1):13-9.
1992: Renty B Franklin; D B Ekiko; Leslie C Costello
Prolactin stimulates transcription of aspartate aminotransferase in prostate cells.
Molecular and cellular endocrinology 1992;90(1):27-32.
1991: Leslie C Costello; Renty B Franklin
Concepts of citrate production and secretion by prostate. 1. Metabolic relationships.
The Prostate 1991;18(1):25-46.
1991: Leslie C Costello; Renty B Franklin
Concepts of citrate production and secretion by prostate: 2. Hormonal relationships in normal and neoplastic prostate.
The Prostate 1991;19(3):181-205.
1990: Renty B Franklin; K Qian; Leslie C Costello
Regulation of aspartate aminotransferase messenger ribonucleic acid level by testosterone.
Journal of steroid biochemistry 1990;35(5):569-74.
1990: Renty B Franklin; Leslie C Costello
Prolactin directly stimulates citrate production and mitochondrial aspartate aminotransferase of prostate epithelial cells.
The Prostate 1990;17(1):13-8.
1990: Renty B Franklin; Lixing Lao; Leslie C Costello
Evidence for two aspartate transport systems in prostate epithelial cells.
The Prostate 1990;16(2):137-45.
1989: Leslie C Costello; Renty B Franklin
Prostate epithelial cells utilize glucose and aspartate as the carbon sources for net citrate production.
The Prostate 1989;15(4):335-42.
1988: Leslie C Costello; M A Khan; Renty B Franklin
Preliminary studies on the cultivation and characterization of mini-pig prostate epithelial cells.
Cell biology international reports 1988;12(8):637-46.
1988: Leslie C Costello; V Akuffo; Renty B Franklin
Testosterone stimulates net citrate production from aspartate by prostate epithelial cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1988;20(4):252-3.
1988: Leslie C Costello; V Akuffo; Renty B Franklin
Net citrate production by isolated prostate epithelial cells.
Enzyme 1988;39(3):125-33.
1987: Renty B Franklin; B I Kukoyi; V Akuffo; Leslie C Costello
Testosterone stimulation of mitochondrial aspartate aminotransferase levels and biosynthesis in rat ventral prostate.
Journal of steroid biochemistry 1987;28(3):247-56.
1986: Renty B Franklin; M W Kahng; V Akuffo; Leslie C Costello
The effect of testosterone on citrate synthesis and citrate oxidation and a proposed mechanism for regulation of net citrate production in prostate.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1986;18(3):177-81.
1984: Renty B Franklin; Leslie C Costello
Glutamate dehydrogenase and a proposed glutamate-aspartate pathway for citrate synthesis in rat ventral prostate.
The Journal of urology 1984;132(6):1239-43.
1984: A J Jackson; Renty B Franklin
Liposome-entrapped diethylstilbestrol effect on prostate gland and plasma testosterone levels in rats.
Endocrinology 1984;115(2):538-43.
1984: Renty B Franklin; M A Khan; Leslie C Costello
Testosterone stimulation of mitochondrial aspartate aminotransferase in organ cultures of rat ventral prostate.
Journal of steroid biochemistry 1984;20(3):709-13.
1982: Renty B Franklin; R L Brandly; Leslie C Costello
Mitochondrial aspartate aminotransferase and the effect of testosterone on citrate production in rat ventral prostate.
The Journal of urology 1982;127(4):798-802.
1982: M A Khan; W Seibel; Renty B Franklin; D V Provenza; Leslie C Costello
Growth pattern and citrate production in organ cultures of adult rat ventral prostate.
The Prostate 1982;3(4):391-403.
1982: Renty B Franklin; R L Brandly; Leslie C Costello
Effect of inhibitors of RNA and protein synthesis on mitochondrial aspartate aminotransferase response to testosterone in rat ventral prostate.
The Prostate 1982;3(6):637-42.
1981: Leslie C Costello; Renty B Franklin
Aconitase activity, citrate oxidation, and zinc inhibition in rat ventral prostate.
Enzyme 1981;26(6):281-7.
1980: F Toghrol; Renty B Franklin; Leslie C Costello
Citrate synthesis from fatty acids and amino acids in rat ventral prostate.
Enzyme 1980;25(6):371-6.
1978: Renty B Franklin; Leslie C Costello
Isocitrate uptake and citrate production by rat ventral prostate fragments.
Investigative urology 1978;16(1):44-7.
1978: Leslie C Costello; G Fadika; Renty B Franklin
Citrate and isocitrate utilization by rat ventral prostate mitochondria.
Enzyme 1978;23(3):176-81.
1977: Renty B Franklin; Leslie C Costello; G K Littleton
Citrate uptake and oxidation by fragments of rat ventral prostate.
Enzyme 1977;22(1):45-51.
1976: Leslie C Costello; Renty B Franklin; R Stacey
Mitochondrial isocitrate dehydrogenase and isocitrate oxidation of rat ventral prostate.
Enzyme 1976;21(6):495-506.
1975: R Stacey; Leslie C Costello; Renty B Franklin
Hypocitricemic response to surgical stress in rats.
The Journal of surgical research 1975;19(6):391-5.
1975: Renty B Franklin; A H Tashjian
Intravenous infusion of prostaglandin E2 raises plasma calcium concentration in the rat.
Endocrinology 1975;97(1):240-3.
1973: Renty B Franklin; Leslie C Costello; R Stacey; R Stephens
Calcitonin effects on plasma and urinary citrate levels in rats.
The American journal of physiology 1973;225(5):1178-80.
1970: Leslie C Costello; R Stracey; Renty B Franklin
Parathyroid hormone effects on soft-tissue citrate levels.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1970;2(4):242-5.