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Robin Franklin

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Simona Lange; Herbert A Reitsamer; Eva Rohde; Herbert Tempfer; Andrea Trost; Ludwig Aigner; Hannelore Bauer; Hans-Christian Bauer; Robin J M Franklin; Francisco J Rivera
Brain pericyte plasticity as a potential drug target in CNS repair.
Tracy J Yuen; Chao Zhao; Robin J M Franklin; Marie C Harrisingh; Kory R Johnson; Henry McFarland; Veronique E Miron; Jacqueline Quandt; Matthew Swire; Anna Williams; Charles Ffrench-Constant
Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.
Robin J M Franklin; Timothy J Bussey
Do your glial cells make you clever?

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2013: Simona Lange; Herbert A Reitsamer; Eva Rohde; Herbert Tempfer; Andrea Trost; Ludwig Aigner; Hannelore Bauer; Hans-Christian Bauer; Robin J M Franklin; Francisco J Rivera
Brain pericyte plasticity as a potential drug target in CNS repair.
Drug discovery today 2013;18(9-10):456-63.
2013: Tracy J Yuen; Chao Zhao; Robin J M Franklin; Marie C Harrisingh; Kory R Johnson; Henry McFarland; Veronique E Miron; Jacqueline Quandt; Matthew Swire; Anna Williams; Charles Ffrench-Constant
Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.
Brain : a journal of neurology 2013;136(Pt 4):1035-47.
2013: Robin J M Franklin; Timothy J Bussey
Do your glial cells make you clever?
Cell stem cell 2013;12(3):265-6.
2013: Josephine M J Stoffels; Miriam E van Strien; Chao Zhao; Jenny C de Jonge; Charles ffrench-Constant; Robin J M Franklin; Dick Hoekstra; Dan Ma; Olaf Maier; Anita Nomden; Zuzana Sisková; Mirjana Stancic; Wia Baron
Fibronectin aggregation in multiple sclerosis lesions impairs remyelination.
Brain : a journal of neurology 2013;136(Pt 1):116-31.
2012: Miyuu Tanaka; Jyoji Yamate; Tadao Serikawa; Katsumi Soma; Robin J M Franklin; Takeshi Izawa; Takashi Kuramoto; Mitsuru Kuwamura
Abnormal myelinogenesis in the central nervous system of the VF mutant rat with recoverable tremor.
Brain research 2012;1488():104-12.
2012: Robin J M Franklin; Julia M Edgar; Charles ffrench-Constant; Kenneth J Smith
Neuroprotection and repair in multiple sclerosis.
Nature reviews. Neurology 2012;8(11):624-34.
2012: Nicolas Granger; Helen Blamires; Robin J M Franklin; Nick D Jeffery
Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model.
Brain : a journal of neurology 2012;135(Pt 11):3227-37.
2012: Jeffrey K Huang; David Lafont; Glaucia Monteiro de Castro; Sandrine Pouly; paola francesca zaratin; Chao Zhao; Carina C Ferrari; Beatrice Greco; Robin J M Franklin
Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z.
The American journal of pathology 2012;181(5):1518-23.
2012: Anna Jagielska; Adele L Norman; Krystyn J Van Vliet; Graeme Whyte; Jochen Guck; Robin J M Franklin
Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.
Stem cells and development 2012;21(16):2905-14.
2012: Markus Kipp; Gianvito Martino; Marion Victor; Robin J M Franklin
Endogeneous remyelination: findings in human studies.
CNS & neurological disorders drug targets 2012;11(5):598-609.
2012: David W Hampton; Neill Innes; Doron Merkler; Chao Zhao; Robin J M Franklin; Siddharthan Chandran
Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency.
The American journal of pathology 2012;180(5):1897-905.
2012: S Y Christin Chong; Stephen P J Fancy; Robin J M Franklin; Angela T Hahn; Q Richard Lu; Aaron W McGee; Sheila S Rosenberg; David H Rowitch; Yun-An A Shen; Xiaomei Xu; Li I Zhang; Chao Zhao; Binhai Zheng; Jonah R Chan
Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(4):1299-304.
2012: Jeffrey K Huang; Robin J M Franklin
Current status of myelin replacement therapies in multiple sclerosis.
Progress in brain research 2012;201():219-31.
2011: Jeffrey K Huang; David H Rowitch; Chao Zhao; Stephen P J Fancy; Charles ffrench-Constant; Robin J M Franklin
Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2011;8(4):650-8.
2011: Jeffrey K Huang; Robin J M Franklin
Regenerative medicine in multiple sclerosis: identifying pharmacological targets of adult neural stem cell differentiation.
Neurochemistry international 2011;59(3):329-32.
2011: Stephen P J Fancy; Robin J M Franklin; Emily P Harrington; Eric J Huang; Roel Nusse; Jose J Otero; Sergio E Baranzini; Charlotte C Bruce; John C Silbereis; Tracy J Yuen; Chao Zhao; David H Rowitch
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.
Nature neuroscience 2011;14(8):1009-16.
2011: Jessica L Zambonin; Chao Zhao; Iryna Ziabreva; Graham R Campbell; Sarah Engeham; Robin J M Franklin; Josa M Frischer; Hans Lassmann; Sok Ee Lee; Nobuhiko Ohno; Nadine Schwarz; Bruce D Trapp; Doug M Turnbull; Don J Mahad
Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis.
Brain : a journal of neurology 2011;134(Pt 7):1901-13.
2011: Mitsuru Kuwamura; Kazuo Inumaki; Miyuu Tanaka; Makoto Shirai; Takeshi Izawa; Jyoji Yamate; Robin J M Franklin; Takashi Kuramoto; Tadao Serikawa
Oligodendroglial pathology in the development of myelin breakdown in the dmy mutant rat.
Brain research 2011;1389():161-8.
2011: Hartmut B F Pohl; Cristina Porcheri; Thomas Mueggler; Lukas C Bachmann; Gianvito Martino; Dieter Riethmacher; Robin J M Franklin; Markus Rudin; Ueli Suter
Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(3):1069-80.
2011: Stephen P J Fancy; Robin J M Franklin; Sergio E Baranzini; Jonah R Chan; David H Rowitch
Myelin regeneration: a recapitulation of development?
Annual review of neuroscience 2011;34():21-43.
2011: Jeffrey K Huang; Andrew Jarjour; Brahim Nait Oumesmar; Christophe Kerninon; Anna Williams; Wojciech Krezel; Hiroyuki Kagechika; Julien Bauer; Chao Zhao; Pierre Chambon; Charles ffrench-Constant; Anne Baron-Van Evercooren; Robin J M Franklin
Retinoid X receptor gamma signaling accelerates CNS remyelination.
Nature neuroscience 2011;14(1):45-53.
2010: Andreas F Christ; Kristian Franze; Helene Gautier; Pouria Moshayedi; James Fawcett; Robin J M Franklin; Ragnhildur T Karadottir; Jochen Guck
Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy.
Journal of biomechanics 2010;43(15):2986-92.
2010: Iryna Ziabreva; Graham Campbell; Julia Rist; Jessica Zambonin; Joanna Rorbach; Mateusz M Wydro; Hans Lassmann; Robin J M Franklin; Don Mahad
Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes.
Glia 2010;58(15):1827-37.
2010: Emily P Harrington; Chao Zhao; Stephen P J Fancy; Sovann Kaing; Robin J M Franklin; David H Rowitch
Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination.
Annals of neurology 2010;68(5):703-16.
2010: Clare E Buckley; Anita Marguerie; Alan G Roach; Paul Goldsmith; Angeleen Fleming; Wendy K Alderton; Robin J M Franklin
Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects.
Neuropharmacology 2010;59(3):149-59.
2010: Stephen P J Fancy; Mark R Kotter; Emily P Harrington; Jeffrey K Huang; Chao Zhao; David H Rowitch; Robin J M Franklin
Overcoming remyelination failure in multiple sclerosis and other myelin disorders.
Experimental neurology 2010;225(1):18-23.
2010: Takeshi Izawa; Jyoji Yamate; Robin J M Franklin; Mitsuru Kuwamura
Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat.
Brain research 2010;1349():105-14.
2010: Malgorzata Zawadzka; Leanne E Rivers; Stephen P J Fancy; Chao Zhao; Richa Tripathi; Françoise Jamen; Kaylene Young; Alexander Goncharevich; Hartmut Pohl; Matteo Rizzi; David H Rowitch; Nicoletta Kessaris; Ueli Suter; William D Richardson; Robin J M Franklin
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.
Cell stem cell 2010;6(6):578-90.
2010: Perrine Barraud; Xiaoling He; Chao Zhao; Maeve A Caldwell; Robin J M Franklin
FGF but not EGF induces phosphorylation of the cAMP response element binding protein in olfactory mucosa-derived cell cultures.
Experimental cell research 2010;316(9):1489-99.
2010: Gianvito Martino; Robin J M Franklin; Douglas A Kerr; Anne Baron Van Evercooren
Stem cell transplantation in multiple sclerosis: current status and future prospects.
Nature reviews. Neurology 2010;6(5):247-55.
2010: Clare E Buckley; Anita Marguerie; Wendy K Alderton; Robin J M Franklin
Temporal dynamics of myelination in the zebrafish spinal cord.
Glia 2010;58(7):802-12.
2010: Takeshi Izawa; Jyoji Yamate; Robin J M Franklin; Mitsuru Kuwamura
Abnormal myelinogenesis both in the white and gray matter of the attractin-deficient mv rat.
Brain research 2010;1312():145-55.
2010: Robin J M Franklin; Charles ffrench-Constant
Stem cell treatments and multiple sclerosis.
BMJ (Clinical research ed.) 2010;340():c1387.
2010: Charlotte C Bruce; Chao Zhao; Robin J M Franklin
Remyelination - An effective means of neuroprotection.
Hormones and behavior 2010;57(1):56-62.
2009: Chao Zhao; Stephen P J Fancy; Robin J M Franklin; Charles ffrench-Constant
Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination.
Journal of neuroscience research 2009;87(15):3447-55.
2009: Natalie D Bull; Karen-Amanda Irvine; Robin J M Franklin; Keith R Martin
Transplanted oligodendrocyte precursor cells reduce neurodegeneration in a model of glaucoma.
Investigative ophthalmology & visual science 2009;50(9):4244-53.
2009: Stephen P J Fancy; Sergio E Baranzini; Chao Zhao; Dong-In Yuk; Karen-Amanda Irvine; Sovann Kaing; Nader Sanai; Robin J M Franklin; David H Rowitch
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.
Genes & development 2009;23(13):1571-85.
2009: Sha Mi; Robert H Miller; Wei Tang; Xinhua Lee; Bing Hu; Wutain Wu; Yiping Zhang; Christopher B Shields; Yongjie Zhang; Steven Miklasz; Diana Shea; Jeff Mason; Robin J M Franklin; Benxiu Ji; Zhaohui Shao; Alain Chédotal; Frederic Bernard; Aude Roulois; Janfeng Xu; Vincent Jung; Blake Pepinsky
Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells.
Annals of neurology 2009;65(3):304-15.
2009: Alexandra S Baer; Yasir A Syed; Sung Ung Kang; Dieter Mitteregger; Raluca Vig; Charles Ffrench-Constant; Robin J M Franklin; Friedrich Altmann; Gert Lubec; Mark R Kotter
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.
Brain : a journal of neurology 2009;132(Pt 2):465-81.
2008: Julia M Rist; Robin J M Franklin
Taking ageing into account in remyelination-based therapies for multiple sclerosis.
Journal of the neurological sciences 2008;274(1-2):64-7.
2008: Robin J M Franklin; Charles ffrench-Constant
Remyelination in the CNS: from biology to therapy.
Nature reviews. Neuroscience 2008;9(11):839-55.
2008: David W Hampton; Jane Anderson; Gareth Pryce; Karen-Amanda Irvine; Gavin Giovannoni; James W Fawcett; Alastair Compston; Robin J M Franklin; David Baker; Siddharthan Chandran
An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.
Journal of neuroimmunology 2008;201-202():200-11.
2008: Siming Shen; Juan Sandoval; Victoria A Swiss; Jiadong Li; Jeffrey L Dupree; Robin J M Franklin; Patrizia Casaccia-Bonnefil
Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.
Nature neuroscience 2008;11(9):1024-34.
2008: Chao Zhao; Stephen P J Fancy; Charles ffrench-Constant; Robin J M Franklin
Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination.
Neurobiology of disease 2008;31(2):209-17.
2008: J M Anderson; David W Hampton; R Patani; G Pryce; R Anthony Crowther; R Reynolds; Robin J M Franklin; Gavin Giovannoni; D A S Compston; D Baker; Maria Grazia Spillantini; Siddharthan Chandran
Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.
Brain : a journal of neurology 2008;131(Pt 7):1736-48.
2008: Robin J M Franklin; Mark R Kotter
The biology of CNS remyelination: the key to therapeutic advances.
Journal of neurology 2008;255 Suppl 1():19-25.
2008: Takeshi Izawa; Shigeo Takenaka; Hideshi Ihara; Takao Kotani; Jyoji Yamate; Robin J M Franklin; Mitsuru Kuwamura
Cellular responses in the spinal cord during development of hypomyelination in the mv rat.
Brain research 2008;1195():120-9.
2008: Chao Zhao; Malgorzata Zawadzka; A J A Roulois; Charlotte C Bruce; Robin J M Franklin
Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells: defining cellular targets.
Journal of the neurological sciences 2008;265(1-2):12-6.
2008: Siddharthan Chandran; David Hunt; Alexis Joannides; Chao Zhao; Alastair Compston; Robin J M Franklin
Myelin repair: the role of stem and precursor cells in multiple sclerosis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1489):171-83.
2008: Lindsay Hamilton; Robin J M Franklin; Nicholas D Jeffery
Quantification of deficits in lateral paw positioning after spinal cord injury in dogs.
BMC veterinary research 2008;4():47.
2008: Daisuke Ito; Naoki Fujita; Chrystelle Ibanez; Nobuo Sasaki; Robin J M Franklin; Nick D Jeffery
Serum-free medium provides a clinically relevant method to increase olfactory ensheathing cell numbers in olfactory mucosa cell culture.
Cell transplantation 2008;16(10):1021-7.
2008: Perrine Barraud; Xiaoling He; Maeve A Caldwell; Robin J M Franklin
Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures.
BMC neuroscience 2008;9():24.
2007: Perrine Barraud; Xiaoling He; Chao Zhao; Chrystelle Ibanez; Ruma Raha-Chowdhury; Maeve A Caldwell; Robin J M Franklin
Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells.
The European journal of neuroscience 2007;26(12):3345-57.
2007: AC Palmer; Nick D Jeffery; Robin J M Franklin
Congenital unilateral absence of the corticospinal tract in a Siamese cat.
Veterinary pathology 2007;44(6):949-51.
2007: Barbara J Skelly; Robin J M Franklin
Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogs.
Veterinary journal (London, England : 1997) 2007;174(3):652-4.
2007: Ashwin Woodhoo; V Sahni; Jennifer M Gilson; Anna Setzu; Robin J M Franklin; William F Blakemore; Rhona Mirsky; Kristjan R Jessen
Schwann cell precursors: a favourable cell for myelin repair in the Central Nervous System.
Brain : a journal of neurology 2007;130(Pt 8):2175-85.
2007: Yves Benninger; Tina Thurnherr; Jorge A Pereira; Sven Krause; Xunwei Wu; Anna Chrostek-Grashoff; Dominik Herzog; Klaus-Armin Nave; Robin J M Franklin; Dies Meijer; Cord Brakebusch; Ueli Suter; João B Relvas
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.
The Journal of cell biology 2007;177(6):1051-61.
2007: A J A Roulois; C Zhao; Malgorzata Zawadzka; C C Bruce; Robin J M Franklin
[Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells].
Revue neurologique 2007;163(6-7):667-71.
2007: Malgorzata Zawadzka; Robin J M Franklin
Myelin regeneration in demyelinating disorders: new developments in biology and clinical pathology.
Current opinion in neurology 2007;20(3):294-8.
2007: Samantha Bowen; Davidson D Ateh; Katrin Deinhardt; Margaret M Bird; Karen M Price; Cathy S Baker; Joanna C Robson; Michael Swash; Wassim Shamsuddin; Shalini Kawar; Tariq El-Tawil; Jesper Roos; Andrew Hoyle; Carole D Nickols; Charles H Knowles; Anthony H Pullen; Phillip J Luthert; Roy O Weller; Majid Hafezparast; Robin J M Franklin; Tamas Revesz; Rosalind H M King; Otto Berninghausen; Elizabeth M C Fisher; Giampietro Schiavo; Joanne E Martin
The phagocytic capacity of neurones.
The European journal of neuroscience 2007;25(10):2947-55.
2007: Chrystelle Ibanez; Daisuke Ito; Malgorzata Zawadzka; Nick D Jeffery; Robin J M Franklin
Calponin is expressed by fibroblasts and meningeal cells but not olfactory ensheathing cells in the adult peripheral olfactory system.
Glia 2007;55(2):144-51.
2007: Lindsay Hamilton; Robin J M Franklin; Nick D Jeffery
Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis.
BMC neuroscience 2007;8():77.
2006: Wen-Wu Li; Jacques Penderis; Chao Zhao; Michael Schumacher; Robin J M Franklin
Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS.
Experimental neurology 2006;202(1):250-4.
2006: Tina Thurnherr; Yves Benninger; Xunwei Wu; Anna Chrostek; Sven M Krause; Klaus-Armin Nave; Robin J M Franklin; Cord Brakebusch; Ueli Suter; João B Relvas
Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(40):10110-9.
2006: Nick D Jeffery; Peter M Smith; Andras Lakatos; Chrystelle Ibanez; Daisuke Ito; Robin J M Franklin
Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy.
Spinal cord 2006;44(10):584-93.
2006: Anna Setzu; Justin D Lathia; Chao Zhao; Karen Wells; Mahendra S Rao; Charles ffrench-Constant; Robin J M Franklin
Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells.
Glia 2006;54(4):297-303.
2006: Chao Zhao; Wen-Wu Li; Robin J M Franklin
Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination.
Neurobiology of aging 2006;27(9):1298-307.
2006: Robin J M Franklin; Chao Zhao
Tyrosine kinases: maiming myelin in leprosy.
Nature medicine 2006;12(8):889-90.
2006: Yves Benninger; Holly Colognato; Tina Thurnherr; Robin J M Franklin; Dino P Leone; Suzana Atanasoski; Klaus-Armin Nave; Charles ffrench-Constant; Ueli Suter; João B Relvas
Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(29):7665-73.
2006: Keith L Ligon; Stephen P J Fancy; Robin J M Franklin; David H Rowitch
Olig gene function in CNS development and disease.
Glia 2006;54(1):1-10.
2006: Daisuke Ito; Chrystelle Ibanez; Hiroyuki Ogawa; Robin J M Franklin; Nick D Jeffery
Comparison of cell populations derived from canine olfactory bulb and olfactory mucosal cultures.
American journal of veterinary research 2006;67(6):1050-6.
2006: Mark D Dunning; Mikko I Kettunen; Charles ffrench-Constant; Robin J M Franklin; Kevin M Brindle
Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres.
NeuroImage 2006;31(1):172-80.
2006: Divya M Chari; Chao Zhao; Mark R Kotter; William F Blakemore; Robin J M Franklin
Corticosteroids delay remyelination of experimental demyelination in the rodent central nervous system.
Journal of neuroscience research 2006;83(4):594-605.
2006: Divya M Chari; Jennifer M Gilson; Robin J M Franklin; William F Blakemore
Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS.
Experimental neurology 2006;198(1):145-53.
2006: Mark R Kotter; Wen-Wu Li; Chao Zhao; Robin J M Franklin
Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(1):328-32.
2005: Nick D Jeffery; Andras Lakatos; Robin J M Franklin
Autologous olfactory glial cell transplantation is reliable and safe in naturally occurring canine spinal cord injury.
Journal of neurotrauma 2005;22(11):1282-93.
2005: Monique Dubois-Dalcq; Charles Ffrench-Constant; Robin J M Franklin
Enhancing central nervous system remyelination in multiple sclerosis.
Neuron 2005;48(1):9-12.
2005: Chao Zhao; Stephen P J Fancy; Laurent Magy; Joanna E Urwin; Robin J M Franklin
Stem cells, progenitors and myelin repair.
Journal of anatomy 2005;207(3):251-8.
2005: Chao Zhao; Stephen P J Fancy; Mark R Kotter; Wen-Wu Li; Robin J M Franklin
Mechanisms of CNS remyelination--the key to therapeutic advances.
Journal of the neurological sciences 2005;233(1-2):87-91.
2005: Mark R Kotter; Chao Zhao; Nico van Rooijen; Robin J M Franklin
Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression.
Neurobiology of disease 2005;18(1):166-75.
2005: A P C Skinner; S Pachnicke; Andras Lakatos; Robin J M Franklin; Nick D Jeffery
Nasal and frontal sinus mucosa of the adult dog contain numerous olfactory sensory neurons and ensheathing glia.
Research in veterinary science 2005;78(1):9-15.
2005: Wen-Wu Li; Anna Setzu; Chao Zhao; Robin J M Franklin
Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination.
Journal of neuroimmunology 2005;158(1-2):58-66.
2004: Heather A Arnett; Stephen P J Fancy; John A Alberta; Chao Zhao; Sheila R Plant; Sovann Kaing; Cedric S Raine; David H Rowitch; Robin J M Franklin; Charles D Stiles
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
Science (New York, N.Y.) 2004;306(5704):2111-5.
2004: Mark D Dunning; Andras Lakatos; Louiza Loizou; Mikko I Kettunen; Charles ffrench-Constant; Kevin M Brindle; Robin J M Franklin
Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(44):9799-810.
2004: Stephen P J Fancy; Chao Zhao; Robin J M Franklin
Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS.
Molecular and cellular neurosciences 2004;27(3):247-54.
2004: Mark F Stidworthy; Stephane Genoud; Wen-Wu Li; Dino P Leone; Ned Mantei; Ueli Suter; Robin J M Franklin
Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination.
Brain : a journal of neurology 2004;127(Pt 9):1928-41.
2004: Charles ffrench-Constant; Holly Colognato; Robin J M Franklin
Neuroscience. The mysteries of myelin unwrapped.
Science (New York, N.Y.) 2004;304(5671):688-9.
2004: Sarah K Williams; Robin J M Franklin; Susan C Barnett
Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins.
The Journal of comparative neurology 2004;470(1):50-62.
2004: Rachel H Woodruff; Marcus Fruttiger; William D Richardson; Robin J M Franklin
Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination.
Molecular and cellular neurosciences 2004;25(2):252-62.
2004: Anna Setzu; Charles ffrench-Constant; Robin J M Franklin
CNS axons retain their competence for myelination throughout life.
Glia 2004;45(3):307-11.
2003: Andras Lakatos; Susan C Barnett; Robin J M Franklin
Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter.
Experimental neurology 2003;184(1):237-46.
2003: Jacques Penderis; Rachel H Woodruff; Andras Lakatos; Wen-Wu Li; Mark D Dunning; Chao Zhao; Mark Marchionni; Robin J M Franklin
Increasing local levels of neuregulin (glial growth factor-2) by direct infusion into areas of demyelination does not alter remyelination in the rat CNS.
The European journal of neuroscience 2003;18(8):2253-64.
2003: Mark F Stidworthy; Stephane Genoud; Ueli Suter; Ned Mantei; Robin J M Franklin
Quantifying the early stages of remyelination following cuprizone-induced demyelination.
Brain pathology (Zurich, Switzerland) 2003;13(3):329-39.
2003: Jacques Penderis; Simon A Shields; Robin J M Franklin
Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system.
Brain : a journal of neurology 2003;126(Pt 6):1382-91.
2003: Chao Zhao; Padraig M Strappe; Andrew M L Lever; Robin J M Franklin
Lentiviral vectors for gene delivery to normal and demyelinated white matter.
Glia 2003;42(1):59-67.
2003: Robin J M Franklin
Remyelination by transplanted olfactory ensheathing cells.
Anatomical record. Part B, New anatomist 2003;271(1):71-6.
2003: Andras Lakatos; Peter M Smith; Susan C Barnett; Robin J M Franklin
Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells.
Brain : a journal of neurology 2003;126(Pt 3):598-609.
2002: Andras Lakatos; Robin J M Franklin
Transplant mediated repair of the central nervous system: an imminent solution?
Current opinion in neurology 2002;15(6):701-5.
2002: Robin J M Franklin
Why does remyelination fail in multiple sclerosis?
Nature reviews. Neuroscience 2002;3(9):705-14.
2002: Peter M Smith; Andras Lakatos; Susan C Barnett; Nick D Jeffery; Robin J M Franklin
Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS.
Experimental neurology 2002;176(2):402-6.
2002: Fraser J Sim; Chao Zhao; Wen-Wu Li; Andras Lakatos; Robin J M Franklin
Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS.
Molecular and cellular neurosciences 2002;20(4):669-82.
2002: Robin J M Franklin; Chao Zhao; Fraser J Sim
Ageing and CNS remyelination.
Neuroreport 2002;13(7):923-8.
2002: Robin J M Franklin
Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia.
Brain research bulletin 2002;57(6):827-32.
2002: Fraser J Sim; Chao Zhao; Jacques Penderis; Robin J M Franklin
The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(7):2451-9.
2002: Barbara J Skelly; Robin J M Franklin
Recognition and diagnosis of lysosomal storage diseases in the cat and dog.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine 2002;16(2):133-41.
2002: Robin J M Franklin
Obtaining olfactory ensheathing cells from extra-cranial sources a step closer to clinical transplant-mediated repair of the CNS?
Brain : a journal of neurology 2002;125(Pt 1):2-3.
2002: MT O'Leary; GL Hinks; H M Charlton; Robin J M Franklin
Increasing local levels of IGF-I mRNA expression using adenoviral vectors does not alter oligodendrocyte remyelination in the CNS of aged rats.
Molecular and cellular neurosciences 2002;19(1):32-42.
2001: Peter M Smith; Fraser J Sim; Susan C Barnett; Robin J M Franklin
SCIP/Oct-6, Krox-20, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells.
Glia 2001;36(3):342-53.
2001: Peter M Smith; Robin J M Franklin
The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination.
Journal of neuroimmunology 2001;119(2):261-8.
2001: Christian S Lobsiger; P M Smith; Johanna Buchstaller; Beat Schweitzer; Robin J M Franklin; Ueli Suter; Verdon Taylor
SpL201: a conditionally immortalized Schwann cell precursor line that generates myelin.
Glia 2001;36(1):31-47.
2001: Nick D Jeffery; Jacques Penderis; Peter M Smith; Robin J M Franklin
Bridging the divide: spinal cord repair by cellular transplantation--from research laboratory to therapeutic application.
The Journal of small animal practice 2001;42(9):428-32.
2001: Mark R Kotter; Anna Setzu; Fraser J Sim; Nico van Rooijen; Robin J M Franklin
Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination.
Glia 2001;35(3):204-12.
2001: AC Palmer; J J Callanan; L A Guerin; B J Sheahan; N Stronach; Robin J M Franklin
Progressive encephalomyelopathy and cerebellar degeneration in 10 captive-bred cheetahs.
The Veterinary record 2001;149(2):49-54.
2001: João B Relvas; Anna Setzu; Wia Baron; PC Buttery; S E LaFlamme; Robin J M Franklin; Charles ffrench-Constant
Expression of dominant-negative and chimeric subunits reveals an essential role for beta1 integrin during myelination.
Current biology : CB 2001;11(13):1039-43.
2001: Robert D Jolly; P C Ehrlich; Robin J M Franklin; D F Macdougall; AC Palmer
Histological diagnosis of mucopolysaccharidosis IIIA in a wire-haired dachshund.
The Veterinary record 2001;148(18):564-7.
2001: GL Hinks; Divya M Chari; MT O'Leary; Chao Zhao; HS Keirstead; William F Blakemore; Robin J M Franklin
Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X-irradiated compared to normal CNS.
Neuropathology and applied neurobiology 2001;27(1):59-67.
2001: Robin J M Franklin; GL Hinks; Rachel H Woodruff; MT O'Leary
What roles do growth factors play in CNS remyelination?
Progress in brain research 2001;132():185-93.
2000: Andras Lakatos; Robin J M Franklin; Susan C Barnett
Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes.
Glia 2000;32(3):214-25.
2000: GL Hinks; Robin J M Franklin
Delayed changes in growth factor gene expression during slow remyelination in the CNS of aged rats.
Molecular and cellular neurosciences 2000;16(5):542-56.
2000: Robin J M Franklin; Susan C Barnett
Olfactory ensheathing cells and CNS regeneration: the sweet smell of success?
Neuron 2000;28(1):15-8.
2000: Y Iwashita; James W Fawcett; A John Crang; Robin J M Franklin; William F Blakemore
Schwann cells transplanted into normal and X-irradiated adult white matter do not migrate extensively and show poor long-term survival.
Experimental neurology 2000;164(2):292-302.
2000: Susan C Barnett; Claire L Alexander; Y Iwashita; Jennifer M Gilson; J Crowther; L Clark; Laurence T Dunn; Vakis Papanastassiou; Peter G E Kennedy; Robin J M Franklin
Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons.
Brain : a journal of neurology 2000;123 ( Pt 8)():1581-8.
2000: Simon A Shields; William F Blakemore; Robin J M Franklin
Schwann cell remyelination is restricted to astrocyte-deficient areas after transplantation into demyelinated adult rat brain.
Journal of neuroscience research 2000;60(5):571-8.
2000: Robin J M Franklin
The Brown Animal Sanatory Institution--historical lessons for the present?
Veterinary journal (London, England : 1997) 2000;159(3):231-7.
2000: William F Blakemore; Peter M Smith; Robin J M Franklin
Remyelinating the demyelinated CNS.
Novartis Foundation symposium 2000;231():289-98; discussion 298-306.
2000: Fraser J Sim; GL Hinks; Robin J M Franklin
The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain.
Neuroscience 2000;100(1):131-9.
2000: Lawrence Moon; J E Brecknell; Robin J M Franklin; Stephen B Dunnett; James W Fawcett
Robust regeneration of CNS axons through a track depleted of CNS glia.
Experimental neurology 2000;161(1):49-66.
1999: Robin J M Franklin; KL Blaschuk; M C Bearchell; prestoz laetitia; Anna Setzu; Kevin M Brindle; Charles ffrench-Constant
Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain.
Neuroreport 1999;10(18):3961-5.
1999: Robin J M Franklin; GL Hinks
Understanding CNS remyelination: clues from developmental and regeneration biology.
Journal of neuroscience research 1999;58(2):207-13.
1999: Robin J M Franklin; Ian Ramsey
Neurological and urological condition in young boxer dogs.
The Veterinary record 1999;145(15):440.
1999: Simon A Shields; Jennifer M Gilson; William F Blakemore; Robin J M Franklin
Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination.
Glia 1999;28(1):77-83.
1999: GL Hinks; Robin J M Franklin
Distinctive patterns of PDGF-A, FGF-2, IGF-I, and TGF-beta1 gene expression during remyelination of experimentally-induced spinal cord demyelination.
Molecular and cellular neurosciences 1999;14(2):153-68.
1999: Rachel H Woodruff; Robin J M Franklin
The expression of myelin protein mRNAs during remyelination of lysolecithin-induced demyelination.
Neuropathology and applied neurobiology 1999;25(3):226-35.
1999: Ian Ramsey; Kate Chandler; Robin J M Franklin
A movement disorder in boxer pups.
The Veterinary record 1999;144(7):179-80.
1999: Rachel H Woodruff; Robin J M Franklin
Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti-galactocerebroside: a comparative study.
Glia 1999;25(3):216-28.
1998: J S McKay; William F Blakemore; Robin J M Franklin
Trapidil-mediated inhibition of CNS remyelination results from reduced numbers and impaired differentiation of oligodendrocytes.
Neuropathology and applied neurobiology 1998;24(6):498-506.
1998: AC Palmer; William F Blakemore; Robin J M Franklin; L M Frost; R E Gough; J C M Lewis; D F Macdougall; MT O'Leary; L R Stocker
Paralysis in hedgehogs (Erinaceus europaeus) associated with demyelination.
The Veterinary record 1998;143(20):550-2.
1998: Robin J M Franklin; William F Blakemore
Transplanting myelin-forming cells into the central nervous system: principles and practice.
Methods (San Diego, Calif.) 1998;16(3):311-9.
1998: Rachel H Woodruff; Robin J M Franklin
The expression of myelin basic protein exon 1 and exon 2 containing transcripts during myelination of the neonatal rat spinal cord--an in situ hybridization study.
Journal of neurocytology 1998;27(9):683-93.
1997: Robin J M Franklin; Susan C Barnett
Do olfactory glia have advantages over Schwann cells for CNS repair?
Journal of neuroscience research 1997;50(5):665-72.
1997: Robin J M Franklin; Jennifer M Gilson; William F Blakemore
Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system.
Journal of neuroscience research 1997;50(2):337-44.
1997: Neil Scolding; Robin J M Franklin
Remyelination in demyelinating disease.
Baillière's clinical neurology 1997;6(3):525-48.
1997: Robin J M Franklin; Ian Ramsey; R E McKerrell
An inherited neurological disorder of the St Bernard dog characterised by unusual cerebellar cortical dysplasia.
The Veterinary record 1997;140(25):656-7.
1997: Robin J M Franklin; William F Blakemore
To what extent is oligodendrocyte progenitor migration a limiting factor in the remyelination of multiple sclerosis lesions?
Multiple sclerosis (Houndmills, Basingstoke, England) 1997;3(2):84-7.
1997: Rachel H Woodruff; Robin J M Franklin
Growth factors and remyelination in the CNS.
Histology and histopathology 1997;12(2):459-66.
1997: J S McKay; William F Blakemore; Robin J M Franklin
The effects of the growth factor-antagonist, trapidil, on remyelination in the CNS.
Neuropathology and applied neurobiology 1997;23(1):50-8.
1997: Robin J M Franklin; William F Blakemore
Transplanting oligodendrocyte progenitors into the adult CNS.
Journal of anatomy 1997;190 ( Pt 1)():23-33.
1996: Robin J M Franklin; Jennifer M Gilson; I A Franceschini; Susan C Barnett
Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS.
Glia 1996;17(3):217-24.
1996: Robin J M Franklin; Jennifer M Gilson
Remyelination in the CNS of the hypothyroid rat.
Neuroreport 1996;7(9):1526-30.
1996: Robin J M Franklin; S A Bayley; William F Blakemore
Transplanted CG4 cells (an oligodendrocyte progenitor cell line) survive, migrate, and contribute to repair of areas of demyelination in X-irradiated and damaged spinal cord but not in normal spinal cord.
Experimental neurology 1996;137(2):263-76.
1995: William F Blakemore; N J Olby; Robin J M Franklin
The use of transplanted glial cells to reconstruct glial environments in the CNS.
Brain pathology (Zurich, Switzerland) 1995;5(4):443-50.
1995: Robin J M Franklin; Nick D Jeffery; Ian Ramsey
Neuroaxonal dystrophy in a litter of papillon pups.
The Journal of small animal practice 1995;36(10):441-4.
1995: Robin J M Franklin; William F Blakemore
Glial-cell transplantation and plasticity in the O-2A lineage--implications for CNS repair.
Trends in neurosciences 1995;18(3):151-6.
1995: William F Blakemore; A John Crang; Robin J M Franklin; K Tang; S Ryder
Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS.
Glia 1995;13(2):79-91.
1995: Robin J M Franklin; S A Bayley; Richard Milner; Charles ffrench-Constant; William F Blakemore
Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter.
Glia 1995;13(1):39-44.
1994: William F Blakemore; Robin J M Franklin; A John Crang
Repair of demyelinated lesions by glial cell transplantation.
Journal of neurology 1994;242(1 Suppl 1):S61-3.
1993: Susan C Barnett; Robin J M Franklin; William F Blakemore
In vitro and in vivo analysis of a rat bipotential O-2A progenitor cell line containing the temperature-sensitive mutant gene of the SV40 large T antigen.
The European journal of neuroscience 1993;5(10):1247-60.
1993: Robin J M Franklin; William F Blakemore
Requirements for Schwann cell migration within CNS environments: a viewpoint.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1993;11(5):641-9.
1993: Robin J M Franklin; A John Crang; William F Blakemore
The reconstruction of an astrocytic environment in glia-deficient areas of white matter.
Journal of neurocytology 1993;22(5):382-96.
1993: Andrew Groves; Susan C Barnett; Robin J M Franklin; A John Crang; M Mayer; William F Blakemore; Mark Noble
Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells.
Nature 1993;362(6419):453-5.
1993: Robin J M Franklin; A John Crang; William F Blakemore
The role of astrocytes in the remyelination of glia-free areas of demyelination.
Advances in neurology 1993;59():125-33.
1992: A John Crang; Robin J M Franklin; William F Blakemore; Mark Noble; Susan C Barnett; Andrew Groves; Jacqueline Trotter; M Schachner
The differentiation of glial cell progenitor populations following transplantation into non-repairing central nervous system glial lesions in adult animals.
Journal of neuroimmunology 1992;40(2-3):243-53.
1992: Robin J M Franklin; A John Crang; William F Blakemore
The behaviour of meningeal cells following glial cell transplantation into chemically-induced areas of demyelination in the CNS.
Neuropathology and applied neurobiology 1992;18(2):189-200.
1992: Robin J M Franklin; A John Crang; William F Blakemore
Type 1 astrocytes fail to inhibit Schwann cell remyelination of CNS axons in the absence of cells of the O-2A lineage.
Developmental neuroscience 1992;14(2):85-92.
1991: William F Blakemore; Robin J M Franklin
Transplantation of glial cells into the CNS.
Trends in neurosciences 1991;14(8):323-7.
1991: Robin J M Franklin; A John Crang; William F Blakemore
Transplanted type-1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord.
Journal of neurocytology 1991;20(5):420-30.
1991: Robin J M Franklin; Susan C Barnett
The electron microscopic appearance of the beta-galactosidase reaction product.
Acta neuropathologica 1991;81(6):686-7.
1991: A John Crang; Robin J M Franklin; William F Blakemore; Jacqueline Trotter; M Schachner; Susan C Barnett; Mark Noble
Transplantation of normal and genetically engineered glia into areas of demyelination.
Annals of the New York Academy of Sciences 1991;633():563-5.
1990: William F Blakemore; A John Crang; Robin J M Franklin
Transplantation of glial cell cultures into areas of demyelination in the adult CNS.
Progress in brain research 1990;82():225-32.