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Paul Franks

Research Profile

Physiology

Disorders

Activities & Behaviors

Chemicals & Drugs

Insulin

Genes & Molecular Sequences

Single Nucleotide Polymorphism

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Adipose Tissue

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Publications

TOP 3
Jeremy Pomeroy; Frida Renström; Antony Wright; Les Bluck; Magnus Domellof; Anna M Gradmark; Steven E Kahn; Ingrid Mogren; Margareta Persson; Paul W Franks
Maternal physical activity and insulin action in pregnancy and their relationships with infant body composition.
Vincent T van Hees; Emmanuel Carlos Dean León; Martin Eder; Ulf Ekelund; Paul W Franks; Lukas Gorzelniak; Alexander Horsch; Marcelo Pias; Frida Renström; Salman Taherian; Søren Brage
Separating movement and gravity components in an acceleration signal and implications for the assessment of human daily physical activity.
Anders Grøntved; Jørn Wulff Helge; Iben Kynde; Jostein Steene-Johannessen; Sigmund A Anderssen; Paul W Franks; Karsten Froberg; Lars Bo Andersen
Association between plasma leptin and blood pressure in two population-based samples of children and adolescents.

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All Publications

2013: Jeremy Pomeroy; Frida Renström; Antony Wright; Les Bluck; Magnus Domellof; Anna M Gradmark; Steven E Kahn; Ingrid Mogren; Margareta Persson; Paul W Franks
Maternal physical activity and insulin action in pregnancy and their relationships with infant body composition.
Diabetes care 2013;36(2):267-9.
2013: Vincent T van Hees; Emmanuel Carlos Dean León; Martin Eder; Ulf Ekelund; Paul W Franks; Lukas Gorzelniak; Alexander Horsch; Marcelo Pias; Frida Renström; Salman Taherian; Søren Brage
Separating movement and gravity components in an acceleration signal and implications for the assessment of human daily physical activity.
PloS one 2013;8(4):e61691.
2011: Anders Grøntved; Jørn Wulff Helge; Iben Kynde; Jostein Steene-Johannessen; Sigmund A Anderssen; Paul W Franks; Karsten Froberg; Lars Bo Andersen
Association between plasma leptin and blood pressure in two population-based samples of children and adolescents.
Journal of hypertension 2011;29(6):1093-100.
2011: Anders Grøntved; Lars B Andersen; Paul W Franks; Bas Verhage; Nicholas J Wareham; Ulf Ekelund; Ruth J F Loos; Søren Brage
NOS3 variants, physical activity, and blood pressure in the European Youth Heart Study.
American journal of hypertension 2011;24(4):444-50.
2011: Vincent T van Hees; Nicholas J Wareham; Antony Wright; Les Bluck; Søren Brage; Michael Catt; Kong Y Chen; Ulf Ekelund; Anna Gradmark; Marie Löf; Jeremy Pomeroy; Frida Renström; Paul W Franks
Estimation of daily energy expenditure in pregnant and non-pregnant women using a wrist-worn tri-axial accelerometer.
PloS one 2011;6(7):e22922.
2011: Jeanne M McCaffery; Alan R Shuldiner; Rena R Wing; Dana Dabelea; Sam Dagogo-Jack; Linda Delahanty; Jose C Florez; Paul W Franks; Richard Hamman; Kathleen A Jablonski; William C Knowler
TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.
PloS one 2011;6(7):e21518.
2011: Anna Gradmark; Steven E Kahn; Ingrid Mogren; Margareta Persson; Jeremy Pomeroy; Frida Renström; Susanne Steiginga; Antony Wright; Les Bluck; Magnus Domellof; Paul W Franks
Physical activity, sedentary behaviors, and estimated insulin sensitivity and secretion in pregnant and non-pregnant women.
BMC pregnancy and childbirth 2011;11():44.
2011: Jeremy Pomeroy; Søren Brage; Jeffrey M Curtis; Pamela D Swan; William C Knowler; Paul W Franks
Between-monitor differences in step counts are related to body size: implications for objective physical activity measurement.
PloS one 2011;6(4):e18942.
2011: Frida Renström; Dmitry Shungin; Ingegerd Johansson; Jose C Florez; Göran Hallmans; Frank B Hu; Paul W Franks
Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.
Diabetes 2011;60(1):345-54.
2010: Kathleen Jablonski; Jarred B McAteer; Paul I W de Bakker; Paul W Franks; Toni I Pollin; Robert L Hanson; Richa Saxena; Sarah Fowler; Alan R Shuldiner; William C Knowler; David Altshuler; Jose C Florez
Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Diabetes 2010;59(10):2672-81.
2010: Karani S Vimaleswaran; Paul W Franks; Søren Brage; Anders Grontved; Nicholas J Wareham; Ulf Ekelund; Ruth J F Loos
Lack of association between PCK1 polymorphisms and obesity, physical activity, and fitness in European Youth Heart Study (EYHS).
Obesity (Silver Spring, Md.) 2010;18(10):1975-80.
2010: Anna M I Gradmark; Anders Rydh; Frida Renström; Emanuella De Lucia-Rolfe; Alison Sleigh; Peter Nordström; Søren Brage; Paul W Franks
Computed tomography-based validation of abdominal adiposity measurements from ultrasonography, dual-energy X-ray absorptiometry and anthropometry.
The British journal of nutrition 2010;104(4):582-8.
2010: Paul W Franks; Robert L Hanson; William C Knowler; Maurice L Sievers; Peter H Bennett; Helen C Looker
Childhood obesity, other cardiovascular risk factors, and premature death.
The New England journal of medicine 2010;362(6):485-93.
2010: Colleen A Venti; Susanne B Votruba; Paul W Franks; Jonathan Krakoff; Arline D Salbe
Reproducibility of ad libitum energy intake with the use of a computerized vending machine system.
The American journal of clinical nutrition 2010;91(2):343-8.
2009: Karani S Vimaleswaran; Paul W Franks; Søren Brage; Luis B Sardinha; Lars B Andersen; Nicholas J Wareham; Ulf Ekelund; Ruth J F Loos
Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).
Obesity (Silver Spring, Md.) 2009;17(7):1453-7.
2009: Ema C Brito; Valeriya Lyssenko; Frida Renström; Göran Berglund; Peter M Nilsson; Leif Groop; Paul W Franks
Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
Diabetes 2009;58(6):1411-8.
2009: E C Brito; Karani Santhanakrishnan Vimaleswaran; Søren Brage; L B Andersen; L B Sardinha; Nicholas J Wareham; Ulf Ekelund; Ruth J F Loos; Paul W Franks
PPARGC1A sequence variation and cardiovascular risk-factor levels: a study of the main genetic effects and gene x environment interactions in children from the European Youth Heart Study.
Diabetologia 2009;52(4):609-13.
2009: Paul W Franks
Identifying genes for primary hypertension: methodological limitations and gene-environment interactions.
Journal of human hypertension 2009;23(4):227-37.
2009: Jeremy Pomeroy; Anna M Soderberg; Paul W Franks
Gene-lifestyle interactions and their consequences on human health.
Medicine and sport science 2009;54():110-35.
2008: Paul W Franks; Kathleen Jablonski; L M Delahanty; J B McAteer; S E Kahn; William C Knowler; Jose C Florez
Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.
Diabetologia 2008;51(12):2214-23.
2008: Karani S Vimaleswaran; Paul W Franks; Inês Barroso; Soren Brage; Ulf Ekelund; Nicholas J Wareham; Ruth J F Loos
Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure.
American journal of hypertension 2008;21(3):297-302.
2008: Paul W Franks; Olov Rolandsson; S L Debenham; K A Fawcett; F Payne; C Dina; philippe froguel; Karen L Mohlke; Cristen J Willer; T Olsson; N J Wareham; Göran Hallmans; Inês Barroso; Manjinder S Sandhu
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations.
Diabetologia 2008;51(3):458-63.
2007: Paul W Franks; Kathleen Jablonski; L Delahanty; R L Hanson; S E Kahn; David Altshuler; William C Knowler; Jose C Florez
The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program.
Diabetologia 2007;50(12):2451-60.
2007: Paul W Franks; Robert L Hanson; William C Knowler; Carol Moffett; Gleebah Enos; Aniello M Infante; Jonathan Krakoff; Helen C Looker
Childhood predictors of young-onset type 2 diabetes.
Diabetes 2007;56(12):2964-72.
2007: Ulf Ekelund; Paul W Franks; Stephen Sharp; Søren Brage; Nicholas J Wareham
Increase in physical activity energy expenditure is associated with reduced metabolic risk independent of change in fatness and fitness.
Diabetes care 2007;30(8):2101-6.
2007: Søren Brage; Ulf Ekelund; Niels Brage; Mark A Hennings; Karsten Froberg; Paul W Franks; Nicholas J Wareham
Hierarchy of individual calibration levels for heart rate and accelerometry to measure physical activity.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;103(2):682-92.
2007: Ruth J F Loos; Paul W Franks; Richard W Francis; Inês Barroso; Fiona M Gribble; David B Savage; Ken K Ong; Stephen O'Rahilly; Nicholas J Wareham
TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.
Diabetes 2007;56(7):1943-7.
2007: Paul W Franks; Ruth J F Loos; Søren Brage; Stephen O'Rahilly; Nicholas J Wareham; Ulf Ekelund
Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(5):1921-6.
2007: José L Mesa; Ruth J F Loos; Paul W Franks; Ken K Ong; Jian'an Luan; Stephen O'Rahilly; Nicholas J Wareham; Inês Barroso
Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies.
Diabetes 2007;56(3):884-9.
2007: Paul W Franks; Ulf Ekelund; Søren Brage; Jian'an Luan; Alan J Schafer; Stephen O'Rahilly; Inês Barroso; Nicholas J Wareham
PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge.
Diabetologia 2007;50(3):569-73.
2007: Jose C Florez; Kathleen Jablonski; Steven E Kahn; Paul W Franks; Dana Dabelea; Richard Hamman; William C Knowler; David M Nathan; David Altshuler
Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.
Diabetes 2007;56(2):531-6.
2007: Paul W Franks; Jose-Luis Mesa; Anne-Helen Harding; Nicholas J Wareham
Gene-lifestyle interaction on risk of type 2 diabetes.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2007;17(2):104-24.
2006: Paul W Franks; Ruth J F Loos
PGC-1alpha gene and physical activity in type 2 diabetes mellitus.
Exercise and sport sciences reviews 2006;34(4):171-5.
2006: Yan Guo; Lijun Ma; Pablo J Enriori; Juraj Koska; Paul W Franks; Thomas Brookshire; Michael Alexander cowley; Arline D Salbe; Angelo DelParigi; P Antonio Tataranni
Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans.
Obesity (Silver Spring, Md.) 2006;14(9):1562-70.
2006: Inês Barroso; Jian'an Luan; Manjinder S Sandhu; Paul W Franks; Vivion E F Crowley; Alan J Schafer; Stephen O'Rahilly; Nicholas J Wareham
Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.
Diabetologia 2006;49(3):501-5.
2006: Søren Brage; Niels Brage; Ulf Ekelund; Jian'an Luan; Paul W Franks; Karsten Froberg; Nicholas J Wareham
Effect of combined movement and heart rate monitor placement on physical activity estimates during treadmill locomotion and free-living.
European journal of applied physiology 2006;96(5):517-24.
2006: Paul W Franks; Helen C Looker; Sayuko Kobes; Leslie Touger; P Antonio Tataranni; Robert L Hanson; William C Knowler
Gestational glucose tolerance and risk of type 2 diabetes in young Pima Indian offspring.
Diabetes 2006;55(2):460-5.
2005: Paul W Franks; Eric Ravussin; Robert L Hanson; Inge Harper; David Allison; William C Knowler; P Antonio Tataranni; Arline D Salbe
Habitual physical activity in children: the role of genes and the environment.
The American journal of clinical nutrition 2005;82(4):901-8.
2005: Paul W Franks; Jian'an Luan; Inês Barroso; Søren Brage; Jose Luis Gonzalez Sanchez; Ulf Ekelund; Manuel Serrano Ríos; Alan J Schafer; Stephen O'Rahilly; Nicholas J Wareham
Variation in the eNOS gene modifies the association between total energy expenditure and glucose intolerance.
Diabetes 2005;54(9):2795-801.
2005: Paul W Franks; Søren Brage; Jian'an Luan; Ulf Ekelund; Mushtaquar Rahman; I Sadaf Farooqi; Ian Halsall; Stephen O'Rahilly; Nicholas J Wareham
Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity.
Obesity research 2005;13(8):1476-84.
2005: Alejandro Lucia; Félix Gómez-Gallego; Inês Barroso; Manuel Rabadán; Fernando Bandrés; Alejandro F San Juan; José L Chicharro; Ulf Ekelund; Søren Brage; Conrad P Earnest; Nicholas J Wareham; Paul W Franks
PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;99(1):344-8.
2005: Ulf Ekelund; Søren Brage; Paul W Franks; Susie Hennings; Sue Emms; Man-Yu Wong; Nicholas J Wareham
Physical activity energy expenditure predicts changes in body composition in middle-aged healthy whites: effect modification by age.
The American journal of clinical nutrition 2005;81(5):964-9.
2005: Ulf Ekelund; Søren Brage; Paul W Franks; Susie Hennings; Sue Emms; Nicholas J Wareham
Physical activity energy expenditure predicts progression toward the metabolic syndrome independently of aerobic fitness in middle-aged healthy Caucasians: the Medical Research Council Ely Study.
Diabetes care 2005;28(5):1195-200.
2005: Søren Brage; Niels Brage; Paul W Franks; Ulf Ekelund; Nicholas J Wareham
Reliability and validity of the combined heart rate and movement sensor Actiheart.
European journal of clinical nutrition 2005;59(4):561-70.
2004: Yan Guo; Paul W Franks; Thomas Brookshire; P Antonio Tataranni
The intra- and inter-instrument reliability of DXA based on ex vivo soft tissue measurements.
Obesity research 2004;12(12):1925-9.
2004: Paul W Franks; William C Knowler; Saras Nair; Juraj Koska; Yong-Ho Lee; Robert S Lindsay; Brian R Walker; Helen C Looker; Paska A Permana; P Antonio Tataranni; Robert L Hanson
Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians.
Hypertension 2004;44(5):681-8.
2004: Søren Brage; Niels Wedderkopp; Ulf Ekelund; Paul W Franks; Nicholas J Wareham; Lars Bo Andersen; Karsten Froberg
Objectively measured physical activity correlates with indices of insulin resistance in Danish children. The European Youth Heart Study (EYHS).
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(11):1503-8.
2004: Søren Brage; Niels Wedderkopp; Ulf Ekelund; Paul W Franks; Nicholas J Wareham; Lars Bo Andersen; Karsten Froberg
Features of the metabolic syndrome are associated with objectively measured physical activity and fitness in Danish children: the European Youth Heart Study (EYHS).
Diabetes care 2004;27(9):2141-8.
2004: Ulf Ekelund; Luis Sardinha; Sigmund A Anderssen; Maarike Harro; Paul W Franks; Søren Brage; Ashley R Cooper; Lars Bo Andersen; Chris Riddoch; Karsten Froberg
Associations between objectively assessed physical activity and indicators of body fatness in 9- to 10-y-old European children: a population-based study from 4 distinct regions in Europe (the European Youth Heart Study).
The American journal of clinical nutrition 2004;80(3):584-90.
2004: Paul W Franks; Ulf Ekelund; Søren Brage; Man-Yu Wong; Nicholas J Wareham
Does the association of habitual physical activity with the metabolic syndrome differ by level of cardiorespiratory fitness?
Diabetes care 2004;27(5):1187-93.
2004: Ulf Ekelund; Paul W Franks; Nicolas J Wareham; Jan Aman
Oxygen uptakes adjusted for body composition in normal-weight and obese adolescents.
Obesity research 2004;12(3):513-20.
2004: Paul W Franks; Sumit Bhattacharyya; Jian'an Luan; Montague Carl; John Brennand; Benjamin G Challis; Søren Brage; Ulf Ekelund; Rita P S Middelberg; Stephen O'Rahilly; Nicholas J Wareham
Association between physical activity and blood pressure is modified by variants in the G-protein coupled receptor 10.
Hypertension 2004;43(2):224-8.
2004: Paul W Franks; Jian'an Luan; P O Browne; Anne-Helen Harding; Stephen O'Rahilly; V Krishna K Chatterjee; Nicholas J Wareham
Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?
Metabolism: clinical and experimental 2004;53(1):11-6.
2004: Søren Brage; Niels Brage; Paul W Franks; Ulf Ekelund; Man-Yu Wong; Lars Bo Andersen; Karsten Froberg; Nicholas J Wareham
Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(1):343-51.
2003: Paul W Franks; Inês Barroso; Jian'an Luan; Ulf Ekelund; Vivion E F Crowley; Søren Brage; Manjinder S Sandhu; Rupert W Jakes; Rita P S Middelberg; Anne-Helen Harding; Alan J Schafer; Stephen O'Rahilly; Nicholas J Wareham
PGC-1alpha genotype modifies the association of volitional energy expenditure with [OV0312]O2max.
Medicine and science in sports and exercise 2003;35(12):1998-2004.
2003: Inês Barroso; Jian'an Luan; Rita P S Middelberg; Anne-Helen Harding; Paul W Franks; Rupert W Jakes; D Clayton; Alan J Schafer; Stephen O'Rahilly; Nicholas J Wareham
Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.
PLoS biology 2003;1(1):E20.
2003: Søren Brage; Niels Wedderkopp; Paul W Franks; Lars Bo Andersen; Karsten Froberg
Reexamination of validity and reliability of the CSA monitor in walking and running.
Medicine and science in sports and exercise 2003;35(8):1447-54.
2003: Paul W Franks; Stephen H Boutcher
Cardiovascular response of trained preadolescent boys to mental challenge.
Medicine and science in sports and exercise 2003;35(8):1429-35.
2003: Paul W Franks; I Sadaf Farooqi; Jian'an Luan; Man-Yu Wong; Ian Halsall; Stephen O'Rahilly; Nicholas J Wareham
Does physical activity energy expenditure explain the between-individual variation in plasma leptin concentrations after adjusting for differences in body composition?
The Journal of clinical endocrinology and metabolism 2003;88(7):3258-63.
2003: Sumit Bhattacharyya; Jian'an Luan; Benjamin G Challis; Catherine Schmitz; Paul Clarkson; Paul W Franks; Rita P S Middelberg; Julia Keogh; I Sadaf Farooqi; Montague Carl; John Brennand; Nicholas J Wareham; Stephen O'Rahilly
Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.
Diabetes 2003;52(5):1296-9.
2002: Nicholas J Wareham; Paul W Franks; Anne-Helen Harding
Establishing the role of gene-environment interactions in the etiology of type 2 diabetes.
Endocrinology and metabolism clinics of North America 2002;31(3):553-66.
2002: Paul W Franks; Man-Yu Wong; Jian'an Luan; Jo Mitchell; Susie Hennings; Nicholas J Wareham
Non-esterified fatty acid levels and physical inactivity: the relative importance of low habitual energy expenditure and cardio-respiratory fitness.
The British journal of nutrition 2002;88(3):307-13.