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Lars-Ake Fransson

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Ulrika Nilsson; Richard Johnsson; Lars-Ake Fransson; Ulf Ellervik; Katrin Mani
Attenuation of tumor growth by formation of antiproliferative glycosaminoglycans correlates with low acetylation of histone H3.
Katrin Mani; Fang Cheng; Lars-Ake Fransson
Heparan sulfate degradation products can associate with oxidized proteins and proteasomes.
Lars-Ake Fransson; Katrin Mani
Novel aspects of vitamin C: how important is glypican-1 recycling?

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All Publications

2010: Ulrika Nilsson; Richard Johnsson; Lars-Ake Fransson; Ulf Ellervik; Katrin Mani
Attenuation of tumor growth by formation of antiproliferative glycosaminoglycans correlates with low acetylation of histone H3.
Cancer research 2010;70(9):3771-9.
2007: Katrin Mani; Fang Cheng; Lars-Ake Fransson
Heparan sulfate degradation products can associate with oxidized proteins and proteasomes.
The Journal of biological chemistry 2007;282(30):21934-44.
2007: Lars-Ake Fransson; Katrin Mani
Novel aspects of vitamin C: how important is glypican-1 recycling?
Trends in molecular medicine 2007;13(4):143-9.
2006: Katrin Mani; Fang Cheng; Lars-Ake Fransson
Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes.
Glycobiology 2006;16(12):1251-61.
2006: Katrin Mani; Fang Cheng; Lars-Ake Fransson
Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts.
Glycobiology 2006;16(8):711-8.
2005: Roberto Cappai; Fang Cheng; Giuseppe D Ciccotosto; B Elise Needham; Colin L Masters; Gerd Multhaup; Lars-Ake Fransson; Katrin Mani
The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.
The Journal of biological chemistry 2005;280(14):13913-20.
2004: Katrin Mani; Fang Cheng; Staffan Sandgren; Jacob Van Den Born; Birgitta Havsmark; Kan Ding; Lars-Ake Fransson
The heparan sulfate-specific epitope 10E4 is NO-sensitive and partly inaccessible in glypican-1.
Glycobiology 2004;14(7):599-607.
2004: Lars-Ake Fransson; Mattias Belting; Fang Cheng; Mats Jönsson; Katrin Mani; Staffan Sandgren
Novel aspects of glypican glycobiology.
Cellular and molecular life sciences : CMLS 2004;61(9):1016-24.
2004: Katrin Mani; Mattias Belting; Ulf Ellervik; Niklas Falk; Gabriel Svensson; Staffan Sandgren; Fang Cheng; Lars-Ake Fransson
Tumor attenuation by 2(6-hydroxynaphthyl)-beta-D-xylopyranoside requires priming of heparan sulfate and nuclear targeting of the products.
Glycobiology 2004;14(5):387-97.
2004: Katrin Mani; Fang Cheng; Birgitta Havsmark; Samuel David; Lars-Ake Fransson
Involvement of glycosylphosphatidylinositol-linked ceruloplasmin in the copper/zinc-nitric oxide-dependent degradation of glypican-1 heparan sulfate in rat C6 glioma cells.
The Journal of biological chemistry 2004;279(13):12918-23.
2003: Mattias Belting; Katrin Mani; Mats Jönsson; Fang Cheng; Staffan Sandgren; Susanne Jonsson; Kan Ding; Jean-Guy Delcros; Lars-Ake Fransson
Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide.
The Journal of biological chemistry 2003;278(47):47181-9.
2003: Katrin Mani; Fang Cheng; Birgitta Havsmark; Mats Jönsson; Mattias Belting; Lars-Ake Fransson
Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.
The Journal of biological chemistry 2003;278(40):38956-65.
2003: Mats Jönsson; Erik Eklund; Lars-Ake Fransson; Ake Oldberg
Initiation of the decorin glycosaminoglycan chain in the endoplasmic reticulum-Golgi intermediate compartment.
The Journal of biological chemistry 2003;278(24):21415-20.
2002: Fang Cheng; Katrin Mani; Jacob Van Den Born; Kan Ding; Mattias Belting; Lars-Ake Fransson
Nitric oxide-dependent processing of heparan sulfate in recycling S-nitrosylated glypican-1 takes place in caveolin-1-containing endosomes.
The Journal of biological chemistry 2002;277(46):44431-9.
2002: Kan Ding; Katrin Mani; Fang Cheng; Mattias Belting; Lars-Ake Fransson
Copper-dependent autocleavage of glypican-1 heparan sulfate by nitric oxide derived from intrinsic nitrosothiols.
The Journal of biological chemistry 2002;277(36):33353-60.
2002: Mattias Belting; Lubor Borsig; Mark M Fuster; Jillian R Brown; Lo Persson; Lars-Ake Fransson; Jeffrey D Esko
Tumor attenuation by combined heparan sulfate and polyamine depletion.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):371-6.
2001: Kan Ding; Staffan Sandgren; Katrin Mani; Mattias Belting; Lars-Ake Fransson
Modulations of glypican-1 heparan sulfate structure by inhibition of endogenous polyamine synthesis. Mapping of spermine-binding sites and heparanase, heparin lyase, and nitric oxide/nitrite cleavage sites.
The Journal of biological chemistry 2001;276(50):46779-91.
2001: Kan Ding; M Jonsson; Katrin Mani; Staffan Sandgren; Mattias Belting; Lars-Ake Fransson
N-unsubstituted glucosamine in heparan sulfate of recycling glypican-1 from suramin-treated and nitrite-deprived endothelial cells. mapping of nitric oxide/nitrite-susceptible glucosamine residues to clustered sites near the core protein.
The Journal of biological chemistry 2001;276(6):3885-94.
2000: Lars-Ake Fransson; Mattias Belting; Mats Jönsson; Katrin Mani; J Moses; Ake Oldberg
Biosynthesis of decorin and glypican.
Matrix biology : journal of the International Society for Matrix Biology 2000;19(4):367-76.
2000: Katrin Mani; Mats Jönsson; G Edgren; Mattias Belting; Lars-Ake Fransson
A novel role for nitric oxide in the endogenous degradation of heparan sulfate during recycling of glypican-1 in vascular endothelial cells.
Glycobiology 2000;10(6):577-86.
1999: J Moses; Ake Oldberg; Lars-Ake Fransson
Initiation of galactosaminoglycan biosynthesis. Separate galactosylation and dephosphorylation pathways for phosphoxylosylated decorin protein and exogenous xyloside.
European journal of biochemistry / FEBS 1999;260(3):879-84.
1999: Mattias Belting; S Persson; Lars-Ake Fransson
Proteoglycan involvement in polyamine uptake.
The Biochemical journal 1999;338 ( Pt 2)():317-23.
1998: Katrin Mani; Birgitta Havsmark; S Persson; Y Kaneda; H Yamamoto; K Sakurai; S Ashikari; Hiroko Habuchi; S Suzuki; K Kimata; Anders Malmström; Gunilla Westergren-Thorsson; Lars-Ake Fransson
Heparan/chondroitin/dermatan sulfate primer 2-(6-hydroxynaphthyl)-O-beta-D-xylopyranoside preferentially inhibits growth of transformed cells.
Cancer research 1998;58(6):1099-104.
1997: J Moses; Ake Oldberg; Erik Eklund; Lars-Ake Fransson
Biosynthesis of the proteoglycan decorin -- identification of intermediates in galactosaminoglycan assembly.
European journal of biochemistry / FEBS 1997;248(3):767-74.
1997: J Moses; Ake Oldberg; F Cheng; Lars-Ake Fransson
Biosynthesis of the proteoglycan decorin--transient 2-phosphorylation of xylose during formation of the trisaccharide linkage region.
European journal of biochemistry / FEBS 1997;248(2):521-6.
1997: Y Arroyo-Yanguas; F Cheng; A Isaksson; Lars-Ake Fransson; Anders Malmström; Gunilla Westergren-Thorsson
Binding, internalization, and degradation of antiproliferative heparan sulfate by human embryonic lung fibroblasts.
Journal of cellular biochemistry 1997;64(4):595-604.
1997: Fang Cheng; Birgitta Havsmark; K Sakurai; Hiroko Habuchi; S Suzuki; K Yoshida; Lars-Ake Fransson
Effects of primer-concentration on uronosyl-epimerization and sulfation patterns in p-hydroxyphenyl-O-beta-D-xylopyranoside-primed galactosaminoglycans produced by skin fibroblasts.
Glycoconjugate journal 1997;14(2):297-305.
1997: G Edgren; Birgitta Havsmark; Mats Jönsson; Lars-Ake Fransson
Glypican (heparan sulfate proteoglycan) is palmitoylated, deglycanated and reglycanated during recycling in skin fibroblasts.
Glycobiology 1997;7(1):103-12.
1996: F Cheng; D Heinegârd; Lars-Ake Fransson; M Bayliss; J Bielicki; J Hopwood; K Yoshida
Variations in the chondroitin sulfate-protein linkage region of aggrecans from bovine nasal and human articular cartilages.
The Journal of biological chemistry 1996;271(45):28572-80.
1996: Mattias Belting; Birgitta Havsmark; M Jönsson; S Persson; Lars-Ake Fransson
Heparan sulphate/heparin glycosaminoglycans with strong affinity for the growth-promoter spermine have high antiproliferative activity.
Glycobiology 1996;6(2):121-9.
1995: Lars-Ake Fransson; G Edgren; Birgitta Havsmark; A Schmidtchen
Recycling of a glycosylphosphatidylinositol-anchored heparan sulphate proteoglycan (glypican) in skin fibroblasts.
Glycobiology 1995;5(4):407-15.
1994: F Cheng; Dick Heinegård; Anders Malmström; A Schmidtchen; K Yoshida; Lars-Ake Fransson
Patterns of uronosyl epimerization and 4-/6-O-sulphation in chondroitin/dermatan sulphate from decorin and biglycan of various bovine tissues.
Glycobiology 1994;4(5):685-96.
1994: A Schmidtchen; Lars-Ake Fransson
Analysis of heparan-sulphate chains and oligosaccharides from proliferating and quiescent fibroblasts. A proposed model for endoheparanase activity.
European journal of biochemistry / FEBS 1994;223(1):211-21.
1993: Mattias Belting; Lars-Ake Fransson
The growth promoter spermine interacts specifically with dermatan sulfate regions that are rich in L-iduronic acid and possess antiproliferative activity.
Glycoconjugate journal 1993;10(6):453-60.
1993: I Carlstedt; A Herrmann; H Karlsson; John K Sheehan; Lars-Ake Fransson; Gunnar Hansson
Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine.
The Journal of biological chemistry 1993;268(25):18771-81.
1993: Gunilla Westergren-Thorsson; S Persson; A Isaksson; P O Onnervik; Anders Malmström; Lars-Ake Fransson
L-iduronate-rich glycosaminoglycans inhibit growth of normal fibroblasts independently of serum or added growth factors.
Experimental cell research 1993;206(1):93-9.
1993: A Schmidtchen; Lars-Ake Fransson
Hydrophobic interaction chromatography of fibroblast proteoglycans.
Biomedical chromatography : BMC 1993;7(1):48-55.
1992: F Cheng; K Yoshida; Dick Heinegård; Lars-Ake Fransson
A new method for sequence analysis of glycosaminoglycans from heavily substituted proteoglycans reveals non-random positioning of 4- and 6-O-sulphated N-acetylgalactosamine in aggrecan-derived chondroitin sulphate.
Glycobiology 1992;2(6):553-61.
1992: Lars-Ake Fransson; P Karlsson; A Schmidtchen
Effects of cycloheximide, brefeldin A, suramin, heparin and primaquine on proteoglycan and glycosaminoglycan biosynthesis in human embryonic skin fibroblasts.
Biochimica et biophysica acta 1992;1137(3):287-97.
1992: A Schmidtchen; Lars-Ake Fransson
Analysis of glycosaminoglycan chains from different proteoglycan populations in human embryonic skin fibroblasts.
European journal of biochemistry / FEBS 1992;208(2):537-46.
1992: Gunilla Westergren-Thorsson; A Schmidtchen; B Särnstrand; Lars-Ake Fransson; Anders Malmström
Transforming growth factor-beta induces selective increase of proteoglycan production and changes in the copolymeric structure of dermatan sulphate in human skin fibroblasts.
European journal of biochemistry / FEBS 1992;205(1):277-86.
1992: Lars-Ake Fransson; Birgitta Havsmark; K Sakurai; S Suzuki
Sequence analysis of p-hydroxyphenyl-O-beta-D-xyloside initiated and radio-iodinated dermatan sulfate from skin fibroblasts.
Glycoconjugate journal 1992;9(1):45-55.
1991: A Lindblom; G Bengtsson-Olivecrona; Lars-Ake Fransson
Domain structure of endothelial heparan sulphate.
The Biochemical journal 1991;279 ( Pt 3)():821-9.
1991: Gunilla Westergren-Thorsson; P O Onnervik; Lars-Ake Fransson; Anders Malmström
Proliferation of cultured fibroblasts is inhibited by L-iduronate-containing glycosaminoglycans.
Journal of cellular physiology 1991;147(3):523-30.
1991: Lars-Ake Fransson; A Schmidtchen; L Cöster; Anders Malmström
Oligosaccharide mapping of proteoglycan-bound and xyloside-initiated dermatan sulfate from fibroblasts.
Glycoconjugate journal 1991;8(2):108-15.
1990: Lars-Ake Fransson; Birgitta Havsmark; I Silverberg
A method for the sequence analysis of dermatan sulphate.
The Biochemical journal 1990;269(2):381-8.
1990: Gunilla Westergren-Thorsson; B Särnstrand; Lars-Ake Fransson; Anders Malmström
TGF-beta enhances the production of hyaluronan in human lung but not in skin fibroblasts.
Experimental cell research 1990;186(1):192-5.
1990: A Schmidtchen; I Carlstedt; Anders Malmström; Lars-Ake Fransson
Inventory of human skin fibroblast proteoglycans. Identification of multiple heparan and chondroitin/dermatan sulphate proteoglycans.
The Biochemical journal 1990;265(1):289-300.
1990: A Schmidtchen; Roger Sundler; Lars-Ake Fransson
A fibroblast heparan sulphate proteoglycan with a 70 kDa core protein is linked to membrane phosphatidylinositol.
Glycoconjugate journal 1990;7(6):563-72.
1990: A Lindblom; Lars-Ake Fransson
Endothelial heparan sulphate: compositional analysis and comparison of chains from different proteoglycan populations.
Glycoconjugate journal 1990;7(6):545-62.
1989: A Lindblom; I Carlstedt; Lars-Ake Fransson
Identification of the core proteins in proteoglycans synthesized by vascular endothelial cells.
The Biochemical journal 1989;261(1):145-53.
1986: L Cöster; I Carlstedt; S Kendall; Anders Malmström; A Schmidtchen; Lars-Ake Fransson
Structure of proteoheparan sulfates from fibroblasts. Confluent and proliferating fibroblasts produce at least three types of proteoheparan sulfates with functionally different core proteins.
The Journal of biological chemistry 1986;261(26):12079-88.
1986: Lars-Ake Fransson; I Carlstedt; L Cöster; Anders Malmström
The functions of the heparan sulphate proteoglycans.
Ciba Foundation symposium 1986;124():125-42.
1985: Lars-Ake Fransson; I Silverberg; I Carlstedt
Structure of the heparan sulfate-protein linkage region. Demonstration of the sequence galactosyl-galactosyl-xylose-2-phosphate.
The Journal of biological chemistry 1985;260(27):14722-6.
1985: Lars-Ake Fransson; L Cöster; I Carlstedt; Anders Malmström
Domain structure of proteoheparan sulphate from confluent cultures of human embryonic skin fibroblasts.
The Biochemical journal 1985;231(3):683-7.
1984: Lars-Ake Fransson; I Carlstedt; L Cöster; Anders Malmström
Binding of transferrin to the core protein of fibroblast proteoheparan sulfate.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(18):5657-61.
1984: Lars-Ake Fransson; V P Chiarugi
On the co-polymeric structure of dermatan sulfate from normal and transformed 3T3 fibroblasts in confluent cultures.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1984;38(10):829-36.
1983: Lars-Ake Fransson; I Carlstedt; L Cöster; Anders Malmström
Proteoheparan sulfate from human skin fibroblasts. Evidence for self-interaction via the heparan sulfate side chains.
The Journal of biological chemistry 1983;258(23):14342-5.
1983: L Cöster; A Malström; I Carlstedt; Lars-Ake Fransson
The core protein of fibroblast proteoheparan sulphate consists of disulphide-bonded subunits.
The Biochemical journal 1983;215(2):417-9.
1983: I Carlstedt; L Cöster; Anders Malmström; Lars-Ake Fransson
Proteoheparan sulfate from human skin fibroblasts. Isolation and structural characterization.
The Journal of biological chemistry 1983;258(19):11629-35.
1982: Lars-Ake Fransson; Birgitta Havsmark
Structural requirements for heparan sulphate self-association.
Carbohydrate research 1982;110(1):135-44.
1982: Lars-Ake Fransson; Birgitta Havsmark
Structural differences between beef-lung heparan sulphates with specific self-associations.
Carbohydrate research 1982;105(2):215-25.
1982: Lars-Ake Fransson; I Sjöberg
Chemical features of aggregatable heparan sulphates from human-lung fibroblasts.
Carbohydrate research 1982;105(2):205-13.
1982: Lars-Ake Fransson; L Cöster; Anders Malmström; John K Sheehan
Self-association of scleral proteodermatan sulfate. Evidence for interaction via the dermatan sulfate side chains.
The Journal of biological chemistry 1982;257(11):6333-8.
1982: Lars-Ake Fransson; Birgitta Havsmark; V P Chiarugi
Co-polymeric glycosaminoglycans in transformed cells. Transformation-dependent changes in the co-polymeric structure of heparan sulphate.
The Biochemical journal 1982;201(1):233-40.
1982: Lars-Ake Fransson; I Carlstedt; L Cöster; Anders Malmström
The self-associating property of fibroblast proteoheparan sulphate.
Progress in clinical and biological research 1982;102 pt A():435-45.
1981: Lars-Ake Fransson; Birgitta Havsmark; John K Sheehan
Self-association of heparan sulfate. Demonstration of binding by affinity chromatography of free chains on heparan sulfate-substituted agarose gels.
The Journal of biological chemistry 1981;256(24):13039-43.
1981: Lars-Ake Fransson; I Sjöberg; V P Chiarugi
Co-polymeric glycosaminoglycans in transformed cells. Transformation-dependent changes in the self-associating properties of cell-surface heparan sulfate.
The Journal of biological chemistry 1981;256(24):13044-7.
1981: John K Sheehan; I Carlstedt; L Cöster; Anders Malmström; Lars-Ake Fransson
Isopycnic-centrifugation studies in caesium chloride and in caesium sulphate on dermatan sulphate proteoglycans from bovine sclera.
The Biochemical journal 1981;199(3):581-9.
1981: L Cöster; Lars-Ake Fransson; John K Sheehan; Ian A Nieduszynski; C F Phelps
Self-association of dermatan sulphate proteoglycans from bovine sclera.
The Biochemical journal 1981;197(2):483-90.
1981: R Kapoor; C F Phelps; L Cöster; Lars-Ake Fransson
Bovine aortic chondroitin sulphate- and dermatan sulphate-containing proteoglycans. Isolation, fractionation and chemical characterization.
The Biochemical journal 1981;197(2):259-68.
1981: L Cöster; Lars-Ake Fransson
Isolation and characterization of dermatan sulphate proteoglycans from bovine sclera.
The Biochemical journal 1981;193(1):143-53.
1980: Lars-Ake Fransson; Birgitta Havsmark; Ian A Nieduszynski; Thomas N Huckerby
Interaction between heparan sulphate chains. II. Structural characterization of iduronate- and glucuronate-containing sequences in aggregating chains.
Biochimica et biophysica acta 1980;633(1):95-104.
1980: I Sjöberg; Lars-Ake Fransson
Structural studies on heparan sulphate from human lung fibroblasts. Characterization of oligosaccharides obtained by selective periodate oxidation of D-glucuronic acid residues followed by scission in alkali.
The Biochemical journal 1980;191(1):103-10.
1980: Lars-Ake Fransson; I Sjöberg; Birgitta Havsmark
Structural studies on heparan sulphates. Characterization of oligosaccharides; obtained by periodate oxidation and alkaline elimination.
European journal of biochemistry / FEBS 1980;106(1):59-69.