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Henrik Franzyk

Research Profile

Genes & Molecular Sequences

Molecular Structure

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Solid-Phase Synthesis Techniques

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Publications

TOP 3
Jesper Søborg Bahnsen; Henrik Franzyk; Anne Sandberg-Schaal; Hanne Mørck Nielsen
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure.
Yang Liu; Søren Molin; Liang Yang; Henrik Franzyk; Kolja M Knapp; Anders Folkesson
High in vitro antimicrobial activity of β-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis.
Xiaona Jing; Lene Jorgensen; Marina R Kasimova; Martin Malmsten; Camilla Foged; Henrik Franzyk; Mingjun Yang; Hanne Mørck Nielsen
Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues.

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All Publications

2013: Jesper Søborg Bahnsen; Henrik Franzyk; Anne Sandberg-Schaal; Hanne Mørck Nielsen
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure.
Biochimica et biophysica acta 2013;1828(2):223-32.
2013: Yang Liu; Søren Molin; Liang Yang; Henrik Franzyk; Kolja M Knapp; Anders Folkesson
High in vitro antimicrobial activity of β-peptoid-peptide hybrid oligomers against planktonic and biofilm cultures of Staphylococcus epidermidis.
International journal of antimicrobial agents 2013;41(1):20-7.
2012: Xiaona Jing; Lene Jorgensen; Marina R Kasimova; Martin Malmsten; Camilla Foged; Henrik Franzyk; Mingjun Yang; Hanne Mørck Nielsen
Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues.
Biochimica et biophysica acta 2012;1818(11):2660-8.
2012: Jacob Dahlqvist Clausen; Lars Linderoth; Hanne Mørck Nielsen; Henrik Franzyk
Solid-phase route to Fmoc-protected cationic amino acid building blocks.
Amino acids 2012;43(4):1633-41.
2012: Rasmus D Jahnsen; Niels Frimodt-Møller; Henrik Franzyk
Antimicrobial activity of peptidomimetics against multidrug-resistant Escherichia coli: a comparative study of different backbones.
Journal of medicinal chemistry 2012;55(16):7253-61.
2012: Xiaona Jing; Lene Jorgensen; Marina R Kasimova; Martin Malmsten; Camilla Foged; Henrik Franzyk; Anders H Simonsen; Hanne Mørck Nielsen
Interaction of peptidomimetics with bilayer membranes: biophysical characterization and cellular uptake.
Langmuir : the ACS journal of surfaces and colloids 2012;28(11):5167-75.
2011: Line Hein-Kristensen; Kolja M Knapp; Henrik Franzyk; Lone Gram
Bacterial membrane activity of α-peptide/β-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains.
BMC microbiology 2011;11():144.
2011: Pernille Nordly; Karen Smith Korsholm; Esra Alici Pedersen; Tayba Sajid Khilji; Henrik Franzyk; Lene Jorgensen; Hanne Mørck Nielsen; Else Marie Agger; Camilla Foged
Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;77(1):89-98.
2010: Sidsel Frølund; Angelo Bella; Anders Skov Kristensen; Hanne L Ziegler; Matthias Witt; Christian A Olsen; Kristian Strømgaard; Henrik Franzyk; Jerzy W Jaroszewski
Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists.
Journal of medicinal chemistry 2010;53(20):7441-51.
2010: Lars K Ottesen; Jerzy W Jaroszewski; Henrik Franzyk
Ring opening of a resin-bound chiral aziridine with phenol nucleophiles.
The Journal of organic chemistry 2010;75(15):4983-91.
2010: Christian A Olsen; Hanne L Ziegler; Hanne Mørck Nielsen; Niels Frimodt-Møller; Jerzy W Jaroszewski; Henrik Franzyk
Antimicrobial, hemolytic, and cytotoxic activities of beta-peptoid-peptide hybrid oligomers: improved properties compared to natural AMPs.
Chembiochem : a European journal of chemical biology 2010;11(10):1356-60.
2009: François Crestey; Matthias Witt; Jerzy W Jaroszewski; Henrik Franzyk
Expedite protocol for construction of chiral regioselectively N-protected monosubstituted piperazine, 1,4-diazepane, and 1,4-diazocane building blocks.
The Journal of organic chemistry 2009;74(15):5652-5.
2009: Lars K Ottesen; Christian A Olsen; Matthias Witt; Jerzy W Jaroszewski; Henrik Franzyk
Selectively N-protected enantiopure 2,5-disubstituted piperazines: avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(12):2966-78.
2008: Camilla Foged; Henrik Franzyk; Shervin Bahrami; Sven Frokjaer; Jerzy W Jaroszewski; Hanne Mørck Nielsen; Christian A Olsen
Cellular uptake and membrane-destabilising properties of alpha-peptide/beta-peptoid chimeras: lessons for the design of new cell-penetrating peptides.
Biochimica et biophysica acta 2008;1778(11):2487-95.
2008: François Crestey; Matthias Witt; Karla Frydenvang; Dan Staerk; Jerzy W Jaroszewski; Henrik Franzyk
Microwave-assisted ring-opening of activated aziridines with resin-bound amines.
The Journal of organic chemistry 2008;73(9):3566-9.
2008: Christian A Olsen; M Lambert; Matthias Witt; Henrik Franzyk; Jerzy W Jaroszewski
Solid-phase peptide synthesis and circular dichroism study of chiral beta-peptoid homooligomers.
Amino acids 2008;34(3):465-71.
2007: Line Vedel; Gitte Bonke; Camilla Foged; Hanne L Ziegler; Henrik Franzyk; Jerzy W Jaroszewski; Christian A Olsen
Antiplasmodial and prehemolytic activities of alpha-peptide-beta-peptoid chimeras.
Chembiochem : a European journal of chemical biology 2007;8(15):1781-4.
2007: Christian A Olsen; Gitte Bonke; Line Vedel; Anne Adsersen; Matthias Witt; Henrik Franzyk; Jerzy W Jaroszewski
Alpha-peptide/beta-peptoid chimeras.
Organic letters 2007;9(8):1549-52.
2006: Kristian Strømgaard; Lorna Piazzi; Christian A Olsen; Henrik Franzyk; Jerzy W Jaroszewski
Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy.
Magnetic resonance in chemistry : MRC 2006;44(11):1013-22.
2006: Christian A Olsen; Caspar Christensen; Birgitte Nielsen; Mohamed M Farah; Farah M Mohamed; Matthias Witt; Rasmus P Clausen; Jesper L Kristensen; Henrik Franzyk; Jerzy W Jaroszewski
Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids.
Organic letters 2006;8(15):3371-4.
2006: Christian A Olsen; Ian R Mellor; Petrine Wellendorph; Peter N R Usherwood; Matthias Witt; Henrik Franzyk; Jerzy W Jaroszewski
Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers.
ChemMedChem 2006;1(3):303-5.
2005: Christian A Olsen; Malene R Jørgensen; Steen H Hansen; Matthias Witt; Jerzy W Jaroszewski; Henrik Franzyk
Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis.
Organic letters 2005;7(9):1703-6.
2005: Jerzy W Jaroszewski; Dan Staerk; Sören Boe Holm-Móller; Thomas Hógh Jensen; Henrik Franzyk; Brinda Somanadhan
Naravelia zeylanica [corrected] occurrence of primary benzamides in flowering plants.
Natural product research 2005;19(3):291-4.
2005: Malene R Jørgensen; Christian A Olsen; Ian R Mellor; Peter N R Usherwood; Matthias Witt; Henrik Franzyk; Jerzy W Jaroszewski
The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism.
Journal of medicinal chemistry 2005;48(1):56-70.
2004: Christian A Olsen; Matthias Witt; Jerzy W Jaroszewski; Henrik Franzyk
Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4'-dimethoxytrityl protection in the presence of trityl linkers.
The Journal of organic chemistry 2004;69(18):6149-52.
2004: Christian A Olsen; Matthias Witt; Jerzy W Jaroszewski; Henrik Franzyk
Expedient protocol for solid-phase synthesis of secondary and tertiary amines.
Organic letters 2004;6(12):1935-8.
2004: Henrik Franzyk; Carl Erik Olsen; Søren Rosendal Jensen
Dopaol 2-keto- and 2,3-diketoglycosides from Chelone obliqua.
Journal of natural products 2004;67(6):1052-4.
2004: Hanne L Ziegler; Henrik Franzyk; Majid Sairafianpour; Mehrnoush Tabatabai; Mahboubeh D Tehrani; Karim Bagherzadeh; Henry Hägerstrand; Dan Staerk; Jerzy W Jaroszewski
Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues.
Bioorganic & medicinal chemistry 2004;12(1):119-27.
2003: Christian A Olsen; Matthias Witt; Jerzy W Jaroszewski; Henrik Franzyk
Solid-phase polyamine synthesis using piperazine and piperidine building blocks.
Organic letters 2003;5(22):4183-5.
2003: Petrine Wellendorph; Jerzy W Jaroszewski; Steen H Hansen; Henrik Franzyk
A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues.
European journal of medicinal chemistry 2003;38(1):117-22.
2002: Søren Rosendal Jensen; Henrik Franzyk; Eva Wallander
Chemotaxonomy of the Oleaceae: iridoids as taxonomic markers.
Phytochemistry 2002;60(3):213-31.
2002: Jerzy W Jaroszewski; Elin Olafsdottir; Petrine Wellendorph; Jette Christensen; Henrik Franzyk; Brinda Somanadhan; Bogdan A Budnik; Lise Bolt Jørgensen; Vicki Clausen
Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts.
Phytochemistry 2002;59(5):501-11.
2002: Henrik Franzyk; Søren Rosendal Jensen; Carl Erik Olsen; Jon Holbech Rasmussen
Synthesis of novel hydroxymethyl substituted analogues related to carbovir and neplanocin A.
Nucleosides, nucleotides & nucleic acids 2002;21(1):23-43.
2001: Henrik Franzyk; Søren Rosendal Jensen; Carl Erik Olsen
Iridoid glucosides from Myxopyrum smilacifolium.
Journal of natural products 2001;64(5):632-3.
2000: Nina Rønsted; E Gøbel; Henrik Franzyk; Søren Rosendal Jensen; Carl Erik Olsen
Chemotaxonomy of Plantago. Iridoid glucosides and caffeoyl phenylethanoid glycosides.
Phytochemistry 2000;55(4):337-48.
2000: Henrik Franzyk; S M Frederiksen; Søren Rosendal Jensen
Conversion of the iridoid glucoside antirrhinoside into 3-azabicyclo[3.3.0]octane building blocks.
Journal of natural products 2000;63(5):592-5.
2000: Henrik Franzyk; Søren Rosendal Jensen; Carl Erik Olsen; J M Quiroga
A 9-hydroxyiridoid isolated from Junellia seriphioides (Verbenaceae).
Organic letters 2000;2(5):699-700.
2000: Kalina Alipieva; Søren Rosendal Jensen; Henrik Franzyk; Nedjalka Handjieva; Ljuba Evstatieva
Iridoid glucosides from Phlomis tuberosa L. and Phlomis herba-ventis L.
Zeitschrift für Naturforschung. C, Journal of biosciences 2000;55(3-4):137-40.
2000: Henrik Franzyk
Synthetic aspects of iridoid chemistry.
Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles 2000;79():1-114.
1998: R E Krull; Frank R Stermitz; Henrik Franzyk; Søren Rosendal Jensen
Iridoid glycoside biosynthesis in Penstemon secundiflorus. Another H-5, H-9 trans-iridoid glycoside.
Phytochemistry 1998;49(6):1605-8.