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Christophe Fraser

Research Profile

Phenomena

Disorders

Activities & Behaviors

Computer Simulation

Living Beings

HIV-1

Concepts & Ideas

Physiology

Recombination, Genetic

Procedures

Chemicals & Drugs

Anti-HIV Agents

Geographic Areas

Hong Kong

Co-author Network

Publications

TOP 3
Ard I van Sighem; Daniela Bezemer; Frank de Wolf; Iralice Jansen; Maria Prins; Ineke Stolte; Christophe Fraser
Increasing sexual risk behaviour among Dutch men who have sex with men: mathematical models versus prospective cohort data.
Katrina A Lythgoe; Christophe Fraser
New insights into the evolutionary rate of HIV-1 at the within-host and epidemiological levels.
Eric de Silva; Neil M Ferguson; Christophe Fraser
Inferring pandemic growth rates from sequence data.

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All Publications

2012: Ard I van Sighem; Daniela Bezemer; Frank de Wolf; Iralice Jansen; Maria Prins; Ineke Stolte; Christophe Fraser
Increasing sexual risk behaviour among Dutch men who have sex with men: mathematical models versus prospective cohort data.
AIDS (London, England) 2012;26(14):1840-3.
2012: Katrina A Lythgoe; Christophe Fraser
New insights into the evolutionary rate of HIV-1 at the within-host and epidemiological levels.
Proceedings. Biological sciences / The Royal Society 2012;279(1741):3367-75.
2012: Eric de Silva; Neil M Ferguson; Christophe Fraser
Inferring pandemic growth rates from sequence data.
Journal of the Royal Society, Interface / the Royal Society 2012;9(73):1797-808.
2012: Oliver Ratmann; Adam Meijer; Gé Donker; Christophe Fraser; Katia Koelle
Phylodynamic inference and model assessment with approximate bayesian computation: influenza as a case study.
PLoS computational biology 2012;8(12):e1002835.
2012: Ard I van Sighem; Pietro Vernazza; Beatriz Vidondo; Daniela Bezemer; Heiner C Bucher; Frank de Wolf; Steven Derendinger; Christophe Fraser; Martin Gebhardt; Tracy R Glass; André Jeannin; Nicola Low
Resurgence of HIV infection among men who have sex with men in Switzerland: mathematical modelling study.
PloS one 2012;7(9):e44819.
2012: Jeffrey W Eaton; Christophe Fraser; Till Bärnighausen; Eran Bendavid; Anna Bershteyn; David E Bloom; Valentina Cambiano; Jan A C Hontelez; Salal Humair; Leigh F Johnson; Daniel J Klein; Elisa F Long; Andrew N Phillips; Carel Pretorius; Joshua A Salomon; John Stover; Edward A Wenger; Brian G Williams; Timothy B Hallett
HIV treatment as prevention: systematic comparison of mathematical models of the potential impact of antiretroviral therapy on HIV incidence in South Africa.
PLoS medicine 2012;9(7):e1001245.
2011: George Shirreff; Oliver Laeyendecker; Lorenzo Pellis; Christophe Fraser
Transmission selects for HIV-1 strains of intermediate virulence: a modelling approach.
PLoS computational biology 2011;7(10):e1002185.
2011: Lorenzo Pellis; Neil M Ferguson; Christophe Fraser
Epidemic growth rate and household reproduction number in communities of households, schools and workplaces.
Journal of mathematical biology 2011;63(4):691-734.
2010: Christophe Fraser; Deirdre Hollingsworth
Interpretation of correlations in setpoint viral load in transmitting couples.
AIDS (London, England) 2010;24(16):2596-7.
2010: Rebecca F Baggaley; Christophe Fraser
Modelling sexual transmission of HIV: testing the assumptions, validating the predictions.
Current opinion in HIV and AIDS 2010;5(4):269-76.
2010: Daniela Bezemer; Frank de Wolf; Maarten C Boerlijst; Ard I van Sighem; Deirdre Hollingsworth; Christophe Fraser
27 years of the HIV epidemic amongst men having sex with men in the Netherlands: an in depth mathematical model-based analysis.
Epidemics 2010;2(2):66-79.
2010: William P Hanage; Jonathan A Finkelstein; Susan S Huang; Stephen I Pelton; Abbie E Stevenson; Ken Kleinman; Virginia L Hinrichsen; Christophe Fraser
Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete.
Epidemics 2010;2(2):80-4.
2009: Simon Cauchemez; Christl A Donnelly; Carrie Reed; Azra C Ghani; Christophe Fraser; Charlotte K Kent; Lyn Finelli; Neil M Ferguson
Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States.
The New England journal of medicine 2009;361(27):2619-27.
2009: L Pellis; Neil M Ferguson; Christophe Fraser
Threshold parameters for a model of epidemic spread among households and workplaces.
Journal of the Royal Society, Interface / the Royal Society 2009;6(40):979-87.
2009: William P Hanage; Christophe Fraser; Jing Tang; Thomas Richard Connor; Jukka Corander
Hyper-recombination, diversity, and antibiotic resistance in pneumococcus.
Science (New York, N.Y.) 2009;324(5933):1454-7.
2009: Christophe Fraser; Eric J Alm; Martin F Polz; Brian G Spratt; William P Hanage
The bacterial species challenge: making sense of genetic and ecological diversity.
Science (New York, N.Y.) 2009;323(5915):741-6.
2008: Lorenzo Pellis; Neil M Ferguson; Christophe Fraser
The relationship between real-time and discrete-generation models of epidemic spread.
Mathematical biosciences 2008;216(1):63-70.
2008: Deirdre Hollingsworth; Roy M Anderson; Christophe Fraser
HIV-1 transmission, by stage of infection.
The Journal of infectious diseases 2008;198(5):687-93.
2008: Nicholas C Grassly; Christophe Fraser
Mathematical models of infectious disease transmission.
Nature reviews. Microbiology 2008;6(6):477-87.
2008: Daniela Bezemer; Frank de Wolf; Maarten C Boerlijst; Ard I van Sighem; Deirdre Hollingsworth; Maria Prins; Ronald B Geskus; Luuk Gras; Roel A Coutinho; Christophe Fraser
A resurgent HIV-1 epidemic among men who have sex with men in the era of potent antiretroviral therapy.
AIDS (London, England) 2008;22(9):1071-7.
2008: M Elizabeth Halloran; Neil M Ferguson; Stephen Eubank; Stephen Eubank; Derek A T Cummings; Bryan Lewis; Shufu Xu; Christophe Fraser; Anil Vullikanti; Timothy C Germann; Diane Wagener; Richard Beckman; Kai Kadau; Chris Barrett; Catherine A Macken; Donald S. Burke; Philip Cooley
Modeling targeted layered containment of an influenza pandemic in the United States.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4639-44.
2007: Christophe Fraser; Deirdre Hollingsworth; Ruth Chapman; Frank de Wolf; William P Hanage
Variation in HIV-1 set-point viral load: epidemiological analysis and an evolutionary hypothesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17441-6.
2007: Christophe Fraser
Influenza pandemic vaccines: spread them thin?
PLoS medicine 2007;4(6):e228.
2007: Luuk Gras; Anouk M Kesselring; James T Griffin; Ard I van Sighem; Christophe Fraser; Azra C Ghani; Frank Miedema; Peter Reiss; Joep M A Lange; Frank de Wolf
CD4 cell counts of 800 cells/mm3 or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/mm3 or greater.
Journal of acquired immune deficiency syndromes (1999) 2007;45(2):183-92.
2007: Christophe Fraser; Joanne E Tomassini; Liwen Xi; Greg Golm; Michael Watson; Anna R Giuliano; Eliav Barr; Kevin A Ault
Modeling the long-term antibody response of a human papillomavirus (HPV) virus-like particle (VLP) type 16 prophylactic vaccine.
Vaccine 2007;25(21):4324-33.
2007: Christophe Fraser; William P Hanage; Brian G Spratt
Recombination and the nature of bacterial speciation.
Science (New York, N.Y.) 2007;315(5811):476-80.
2007: Christophe Fraser
Estimating individual and household reproduction numbers in an emerging epidemic.
PloS one 2007;2(8):e758.
2007: Katy Turner; William P Hanage; Christophe Fraser; Thomas R Connor; Brian G Spratt
Assessing the reliability of eBURST using simulated populations with known ancestry.
BMC microbiology 2007;7():30.
2006: William P Hanage; Brian G Spratt; Katy Turner; Christophe Fraser
Modelling bacterial speciation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1475):2039-44.
2006: William P Hanage; Christophe Fraser; Brian G Spratt
Sequences, sequence clusters and bacterial species.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1475):1917-27.
2006: Nicholas C Grassly; Christophe Fraser; Jay Wenger; Jagadish M Deshpande; Roland W Sutter; David L Heymann; R Bruce Aylward
New strategies for the elimination of polio from India.
Science (New York, N.Y.) 2006;314(5802):1150-3.
2006: Nicholas C Grassly; Christophe Fraser
Seasonal infectious disease epidemiology.
Proceedings. Biological sciences / The Royal Society 2006;273(1600):2541-50.
2006: Joseph T Wu; Steven Riley; Christophe Fraser; Gabriel M Leung
Reducing the impact of the next influenza pandemic using household-based public health interventions.
PLoS medicine 2006;3(9):e361.
2006: Neil M Ferguson; Derek A T Cummings; Christophe Fraser; James C Cajka; philip cooley; Donald S. Burke
Strategies for mitigating an influenza pandemic.
Nature 2006;442(7101):448-52.
2006: James T Griffin; Christophe Fraser; Luuk Gras; Frank de Wolf; Azra C Ghani
The effect on treatment comparisons of different measurement frequencies in human immunodeficiency virus observational databases.
American journal of epidemiology 2006;163(7):676-83.
2006: William P Hanage; Christophe Fraser; Brian G Spratt
The impact of homologous recombination on the generation of diversity in bacteria.
Journal of theoretical biology 2006;239(2):210-9.
2005: Christophe Fraser
HIV recombination: what is the impact on antiretroviral therapy?
Journal of the Royal Society, Interface / the Royal Society 2005;2(5):489-503.
2005: Neil M Ferguson; Christl A Donnelly; J Hooper; Azra C Ghani; Christophe Fraser; Lucy M. A. Marshall; Richard Rode; P Vernazza; D Lapins; S L Mayer; Roy M Anderson
Adherence to antiretroviral therapy and its impact on clinical outcome in HIV-infected patients.
Journal of the Royal Society, Interface / the Royal Society 2005;2(4):349-63.
2005: Neil M Ferguson; Derek A T Cummings; Simon Cauchemez; Christophe Fraser; Steven Riley; Aronrag Meeyai; Sopon Iamsirithaworn; Donald S. Burke
Strategies for containing an emerging influenza pandemic in Southeast Asia.
Nature 2005;437(7056):209-14.
2005: Azra C Ghani; Christl A Donnelly; D R Cox; James T Griffin; Christophe Fraser; Tai Hing Lam; Lai-Ming Ho; W S Chan; Roy M Anderson; Anthony J Hedley; Gabriel M Leung
Methods for estimating the case fatality ratio for a novel, emerging infectious disease.
American journal of epidemiology 2005;162(5):479-86.
2005: Christophe Fraser; William P Hanage; Brian G Spratt
Neutral microepidemic evolution of bacterial pathogens.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1968-73.
2005: Nicholas C Grassly; Christophe Fraser; Geoff P Garnett
Host immunity and synchronized epidemics of syphilis across the United States.
Nature 2005;433(7024):417-21.
2005: William P Hanage; Christophe Fraser; Brian G Spratt
Fuzzy species among recombinogenic bacteria.
BMC biology 2005;3():6.
2004: Gabriel M Leung; Anthony J Hedley; Lai-Ming Ho; Patsy Chau; Irene O L Wong; Thuan Q Thach; Azra C Ghani; Christl A Donnelly; Christophe Fraser; Steven Riley; Neil M Ferguson; Roy M Anderson; Thomas Tsang; Pak-Yin Leung; Vivian Wong; Jane C K Chan; Eva L H Tsui; Su-Vui Lo; Tai Hing Lam
The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients.
Annals of internal medicine 2004;141(9):662-73.
2004: Christl A Donnelly; Matthew C Fisher; Christophe Fraser; Azra C Ghani; Steven Riley; Neil M Ferguson; Roy M Anderson
Epidemiological and genetic analysis of severe acute respiratory syndrome.
The Lancet infectious diseases 2004;4(11):672-83.
2004: Gabriel M Leung; Pui-Hong Chung; Thomas Tsang; Wilina Lim; Steve K K Chan; Patsy Chau; Christl A Donnelly; Azra C Ghani; Christophe Fraser; Steven Riley; Neil M Ferguson; Roy M Anderson; Yuk-lung Law; T Y W Mok; Tonny Ng; Alex Fu; Pak-Yin Leung; J S M Peiris; Tai Hing Lam; Anthony J Hedley
SARS-CoV antibody prevalence in all Hong Kong patient contacts.
Emerging infectious diseases 2004;10(9):1653-6.
2004: Roy M Anderson; Christophe Fraser; Azra C Ghani; Christl A Donnelly; Steven Riley; Neil M Ferguson; Gabriel M Leung; Tai Hing Lam; Anthony J Hedley
Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004;359(1447):1091-105.
2004: Neil M Ferguson; Christophe Fraser; Christl A Donnelly; Azra C Ghani; Roy M Anderson
Public health. Public health risk from the avian H5N1 influenza epidemic.
Science (New York, N.Y.) 2004;304(5673):968-9.
2004: Christophe Fraser; Steven Riley; Roy M Anderson; Neil M Ferguson
Factors that make an infectious disease outbreak controllable.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6146-51.
2003: Steven Riley; Christophe Fraser; Christl A Donnelly; Azra C Ghani; Laith J Abu-Raddad; Anthony J Hedley; Gabriel M Leung; Lai-Ming Ho; Tai Hing Lam; Thuan Q Thach; Patsy Chau; King-Pan Chan; Su-Vui Lo; Pak-Yin Leung; Thomas Tsang; William Ho; Koon-Hung Lee; E M C Lau; Neil M Ferguson; Roy M Anderson
Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions.
Science (New York, N.Y.) 2003;300(5627):1961-6.
2003: Christl A Donnelly; Azra C Ghani; Gabriel M Leung; Anthony J Hedley; Christophe Fraser; Steven Riley; Laith J Abu-Raddad; Lai-Ming Ho; Thuan Q Thach; Patsy Chau; King-Pan Chan; Tai Hing Lam; Lai-Yin Tse; Thomas Tsang; Shao-Haei Liu; James H B Kong; E M C Lau; Neil M Ferguson; Roy M Anderson
Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong.
Lancet 2003;361(9371):1761-6.
2002: Christophe Fraser; Neil M Ferguson; Frank de Wolf; Azra C Ghani; Geoff P Garnett; Roy M Anderson
Antigen-driven T-cell turnover.
Journal of theoretical biology 2002;219(2):177-92.
2002: Azra C Ghani; Neil M Ferguson; Christophe Fraser; Christl A Donnelly; Sven Danner; Peter Reiss; Joep Lange; Jaap Goudsmit; Roy M Anderson; Frank de Wolf
Viral replication under combination antiretroviral therapy: a comparison of four different regimens.
Journal of acquired immune deficiency syndromes (1999) 2002;30(2):167-76.
2001: Christophe Fraser; Neil M Ferguson; Roy M Anderson
Quantification of intrinsic residual viral replication in treated HIV-infected patients.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15167-72.
2001: Christophe Fraser; Neil M Ferguson; F de Wolf; Roy M Anderson
The role of antigenic stimulation and cytotoxic T cell activity in regulating the long-term immunopathogenesis of HIV: mechanisms and clinical implications.
Proceedings. Biological sciences / The Royal Society 2001;268(1481):2085-95.