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John Fraser

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Deborah A Williamson; Geoffrey W Coombs; John D Fraser; Stephen R Ritchie; Sally A Roberts; Helen Heffernan
Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in New Zealand: Rapid Emergence of Sequence Type 5 (ST5)-SCCmec-IV as the Dominant Community-Associated MRSA Clone.
Stefan J Hermans; Ries J Langley; Richard P Sequeira; Edward N Baker; Heather M Baker; John D Fraser
Structural and functional properties of staphylococcal superantigen-like protein 4.
Katrin Schünemann; Jonathan Sperry; Ian A Wilson; Stephen Connelly; John D Fraser; Renata Kowalczyk; Margaret A Brimble
A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors.

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2013: Deborah A Williamson; Geoffrey W Coombs; John D Fraser; Stephen R Ritchie; Sally A Roberts; Helen Heffernan
Clinical and Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus in New Zealand: Rapid Emergence of Sequence Type 5 (ST5)-SCCmec-IV as the Dominant Community-Associated MRSA Clone.
PloS one 2013;8(4):e62020.
2012: Stefan J Hermans; Ries J Langley; Richard P Sequeira; Edward N Baker; Heather M Baker; John D Fraser
Structural and functional properties of staphylococcal superantigen-like protein 4.
Infection and immunity 2012;80(11):4004-13.
2012: Katrin Schünemann; Jonathan Sperry; Ian A Wilson; Stephen Connelly; John D Fraser; Renata Kowalczyk; Margaret A Brimble
A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(15):5018-24.
2012: Andrew J Wood; John D Fraser; Satya Amirapu; Richard G Douglas
Staphylococcus aureus. Letters to the editor.
American journal of rhinology & allergy 2012;26(3):249-50; author reply 250.
2012: Amanda M Heapy; Geoffrey M Williams; John D Fraser; Margaret A Brimble
Synthesis of a dicarba analogue of human β-defensin-1 using a combined ring closing metathesis--native chemical ligation strategy.
Organic letters 2012;14(3):878-81.
2012: John D Fraser
The value of the interview in medical student selection.
The New Zealand medical journal 2012;125(1361):6-8.
2012: Bruce D Wines; Halina M Trist; John Trowsdale; Thomas Areschoug; William Farrugia; John D Fraser; Gunnar Lindahl; Chloe Ngo; Paul Ramsland
A conserved host and pathogen recognition site on immunoglobulins: structural and functional aspects.
Advances in experimental medicine and biology 2012;946():87-112.
2011: Bruce D Wines; Paul Ramsland; Halina M Trist; Robert Brink; John D Fraser; Sandra Gardam; P Mark Hogarth
Interaction of human, rat, and mouse immunoglobulin A (IgA) with Staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor.
The Journal of biological chemistry 2011;286(38):33118-24.
2011: John D Fraser
Clarifying the mechanism of superantigen toxicity.
PLoS biology 2011;9(9):e1001145.
2011: Nicola Best; John D Fraser; Paul B Rainey; Sally A Roberts; Mark G Thomas; Stephen R Ritchie
Nasal carriage of Staphylococcus aureus in healthy Aucklanders.
The New Zealand medical journal 2011;124(1332):31-9.
2011: Stephen R Ritchie; John D Fraser; Eric Libby; Arthur J Morris; Paul B Rainey; Mark G Thomas
Demographic variation in community-based MRSA skin and soft tissue infection in Auckland, New Zealand.
The New Zealand medical journal 2011;124(1332):21-30.
2010: Deepa Patel; Bruce D Wines; Ries J Langley; John D Fraser
Specificity of staphylococcal superantigen-like protein 10 toward the human IgG1 Fc domain.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6283-92.
2010: Ries Langley; Deepa Patel; Nicola Jackson; Fiona Clow; John D Fraser
Staphylococcal superantigen super-domains in immune evasion.
Critical reviews in immunology 2010;30(2):149-65.
2008: John D Fraser; Thomas Proft
The bacterial superantigen and superantigen-like proteins.
Immunological reviews 2008;225():226-43.
2008: Fiona Clow; John D Fraser; Thomas Proft
Immobilization of proteins to biacore sensor chips using Staphylococcus aureus sortase A.
Biotechnology letters 2008;30(9):1603-7.
2008: Fiona J Radcliff; John D Fraser; Zoe E Wilson; Amanda M Heapy; James E Robinson; Christina J Bryant; Christopher L Flowers; Margaret A Brimble
Anti-Helicobacter pylori activity of derivatives of the phthalide-containing antibacterial agents spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015.
Bioorganic & medicinal chemistry 2008;16(11):6179-85.
2008: Philip A Hopkins; Alison C Pridmore; Stephan Ellmerich; John D Fraser; Hugh H Russell; Robert C Read; Shiranee Sriskandan
Increased surface toll-like receptor 2 expression in superantigen shock.
Critical care medicine 2008;36(4):1267-76.
2007: Heather M Baker; Indira Basu; Matthew C Chung; Tom T Caradoc-Davies; John D Fraser; Edward N Baker
Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins.
Journal of molecular biology 2007;374(5):1298-308.
2007: Matthew C Chung; Bruce D Wines; Heather Baker; Ries J Langley; Edward N Baker; John D Fraser
The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.
Molecular microbiology 2007;66(6):1342-55.
2007: Paul Ramsland; Natasha Willoughby; Halina M Trist; William Farrugia; P Mark Hogarth; John D Fraser; Bruce D Wines
Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15051-6.
2007: Thomas Proft; Birgit Schrage; John D Fraser
The cytokine response to streptococcal superantigens varies between individual toxins and between individuals: implications for the pathogenesis of group A streptococcal diseases.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(7):553-7.
2007: Thomas Proft; John D Fraser
Streptococcal superantigens.
Chemical immunology and allergy 2007;93():1-23.
2006: Birgit Schrage; Guowen Duan; Lily P H Yang; John D Fraser; Thomas Proft
Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;43(6):743-6.
2006: Lily P H Yang; Björn K G Eriksson; Zinta Harrington; Nigel Curtis; Selwyn Lang; Bart J Currie; John D Fraser; Thomas Proft
Variations in the protective immune response against streptococcal superantigens in populations of different ethnicity.
Medical microbiology and immunology 2006;195(1):37-43.
2006: Bruce D Wines; Natasha Willoughby; John D Fraser; P Mark Hogarth
A competitive mechanism for staphylococcal toxin SSL7 inhibiting the leukocyte IgA receptor, Fc alphaRI, is revealed by SSL7 binding at the C alpha2/C alpha3 interface of IgA.
The Journal of biological chemistry 2006;281(3):1389-93.
2005: Lily Yang; Mark Thomas; Andrew F Woodhouse; Diana Martin; John D Fraser; Thomas Proft
Involvement of streptococcal mitogenic exotoxin Z in streptococcal toxic shock syndrome.
Journal of clinical microbiology 2005;43(7):3570-3.
2005: Philip A Hopkins; John D Fraser; Alison C Pridmore; Hugh H Russell; Robert C Read; Shiranee Sriskandan
Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin.
Blood 2005;105(9):3655-62.
2005: Ries Langley; Bruce D Wines; Natasha Willoughby; Indira Basu; Thomas Proft; John D Fraser
The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha RI binding and serum killing of bacteria.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2926-33.
2004: Heather M Baker; Thomas Proft; Phillip D Webb; Vickery Arcus; John D Fraser; Edward N Baker
Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization.
The Journal of biological chemistry 2004;279(37):38571-6.
2004: Proft Thomas; Phillip D Webb; Vanessa Handley; John D Fraser
Identification & characterisation of the two novel streptococcal pyrogenic exotoxins SPE-L & SPE-M.
The Indian journal of medical research 2004;119 Suppl():37-43.
2003: Thomas Proft; Shiranee Sriskandan; Lily Yang; John D Fraser
Superantigens and streptococcal toxic shock syndrome.
Emerging infectious diseases 2003;9(10):1211-8.
2003: Thomas Proft; John D Fraser
Bacterial superantigens.
Clinical and experimental immunology 2003;133(3):299-306.
2003: Thomas Proft; Phillip D Webb; Vanessa Handley; John D Fraser
Two novel superantigens found in both group A and group C Streptococcus.
Infection and immunity 2003;71(3):1361-9.
2002: Meera Unnikrishnan; Daniel M Altmann; Thomas Proft; Faisal Wahid; Jonathan Cohen; John D Fraser; Shiranee Sriskandan
The bacterial superantigen streptococcal mitogenic exotoxin Z is the major immunoactive agent of Streptococcus pyogenes.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2561-9.
2002: Vickery Arcus; Ries Langley; Thomas Proft; John D Fraser; Edward N Baker
The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome.
The Journal of biological chemistry 2002;277(35):32274-81.
2002: See-Tarn Woon; Bruce C Baguley; Brian Palmer; John D Fraser; Lai-Ming Ching
Uptake of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and activation of NF-kappaB in human tumor cell lines.
Oncology research 2002;13(2):95-101.
2001: Thomas Proft; Vickery Arcus; Vanessa Handley; Edward N Baker; John D Fraser
Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J (SPE-I and SPE-J) from Streptococcus pyogenes.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6711-9.
2000: Vickery Arcus; Thomas Proft; J A Sigrell; Heather M Baker; John D Fraser; Edward N Baker
Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus pyogenes.
Journal of molecular biology 2000;299(1):157-68.
2000: Thomas Proft; S L Moffatt; K D Weller; A Paterson; Diana Martin; John D Fraser
The streptococcal superantigen SMEZ exhibits wide allelic variation, mosaic structure, and significant antigenic variation.
The Journal of experimental medicine 2000;191(10):1765-76.
1999: A Bernal; Thomas Proft; John D Fraser; David N Posnett
Superantigens in human disease.
Journal of clinical immunology 1999;19(3):149-57.
1999: Thomas Proft; S L Moffatt; C J Berkahn; John D Fraser
Identification and characterization of novel superantigens from Streptococcus pyogenes.
The Journal of experimental medicine 1999;189(1):89-102.
1998: W G Abbott; P L Tan; A Geursen; John D Fraser; L Forbes; I J Simpson; S Yuan; M A Skinner
TCRBV14S1 and rheumatoid arthritis revisited: abnormalities in the percentage of transcribed TCRBV14S1 family genes in PBMC from rheumatoid arthritis patients.
Scandinavian journal of rheumatology 1998;27(1):68-75.
1997: P L Li; R E Tiedemann; S L Moffat; John D Fraser
The superantigen streptococcal pyrogenic exotoxin C (SPE-C) exhibits a novel mode of action.
The Journal of experimental medicine 1997;186(3):375-83.
1997: A Roussel; Bryan F Anderson; Heather M Baker; John D Fraser; Edward N Baker
Crystal structure of the streptococcal superantigen SPE-C: dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules.
Nature structural biology 1997;4(8):635-43.
1996: R E Tiedemann; John D Fraser
Cross-linking of MHC class II molecules by staphylococcal enterotoxin A is essential for antigen-presenting cell and T cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3958-66.
1996: W G Abbott; M A Skinner; L Voss; Diana Lennon; PL Tan; John D Fraser; I J Simpson; R Ameratunga; A Geursen
Repertoire of transcribed peripheral blood T-cell receptor beta chain variable-region genes in acute rheumatic fever.
Infection and immunity 1996;64(7):2842-5.
1996: W G Abbott; A Geursen; John D Fraser; M A Skinner; PL Tan; J Marbrook
The influence of a recombinant-HBsAg vaccine on the repertoire of transcribed T-cell receptor beta chain variable region genes in peripheral blood in humans.
Vaccine 1996;14(4):301-6.
1995: R E Tiedemann; R J Urban; Jack L Strominger; John D Fraser
Isolation of HLA-DR1.(staphylococcal enterotoxin A)2 trimers in solution.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12156-9.
1995: W G Abbott; A Geursen; John D Fraser; J Marbrook; M A Skinner; PL Tan
The influence of a maternal chronic hepatitis B virus infection on the repertoire of transcribed T-cell receptor beta chain variable region genes in human cord blood.
Hepatology (Baltimore, Md.) 1995;22(4 Pt 1):1034-9.
1995: K R Hudson; R E Tiedemann; R G Urban; S C Lowe; Jack L Strominger; John D Fraser
Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II.
The Journal of experimental medicine 1995;182(3):711-20.
1995: I J Simpson; M A Skinner; A Geursen; J S Peake; W G Abbott; John D Fraser; C M Lockwood; PL Tan
Peripheral blood T lymphocytes in systemic vasculitis: increased T cell receptor V beta 2 gene usage in microscopic polyarteritis.
Clinical and experimental immunology 1995;101(2):220-6.
1993: A Geursen; M A Skinner; L A Townsend; L K Perko; S J Farmiloe; J S Peake; I J Simpson; John D Fraser; PL Tan
Population study of T cell receptor V beta gene usage in peripheral blood lymphocytes: differences in ethnic groups.
Clinical and experimental immunology 1993;94(1):201-7.
1993: John D Fraser
T-cell recognition of superantigens.
Research in immunology 1993;144(3):173-4.
1993: John D Fraser; K R Hudson
Superantigens--remnants of a past process?
Research in immunology 1993;144(3):188-93; discussion 214-22.
1993: K R Hudson; H Robinson; John D Fraser
Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity.
The Journal of experimental medicine 1993;177(1):175-84.
1992: John D Fraser; R G Urban; Jack L Strominger; H Robinson
Zinc regulates the function of two superantigens.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5507-11.