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Keith Frayn

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Chemicals & Drugs

Concepts & Ideas

Postprandial Period

Activities & Behaviors

Fasting

Physiology

Disorders

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Co-Publications
Name
66
Humphreys, Sandy
51
Fielding, Barbara
39
Karpe, Fredrik
23
Samra, JS
20
Summers, Lucinda
18
Clark, ML
12
Robertson, Denise
11
Gibbons, Geoffrey
9
Tan, Garry
8
Ilic, Vera
8
Hodson, Leanne
8
Bickerton, Alex
7
Jackson, Kim
7
Macdonald, Ian
7
Vidal, Hubert

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Publications

TOP 3
Mostad Ingrid L; Bjerve Kristian S; Basu Samar; Sutton Pauline; Frayn Keith N; Grill Valdemar
Addition of n-3 fatty acids to a 4-hour lipid infusion does not affect insulin sensitivity, insulin secretion, or markers of oxidative stress in subjects with type 2 diabetes mellitus.
Kotronen Anna; Seppälä-Lindroos Anneli; Vehkavaara Satu; Bergholm Robert; Frayn Keith N; Fielding Barbara A; Yki-Järvinen Hannele
Liver fat and lipid oxidation in humans.
Roberts R; Hodson L; Dennis A L; Neville M J; Humphreys S M; Harnden K E; Micklem K J; Frayn K N
Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.

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All Publications

2009: Mostad Ingrid L; Bjerve Kristian S; Basu Samar; Sutton Pauline; Frayn Keith N; Grill Valdemar
Addition of n-3 fatty acids to a 4-hour lipid infusion does not affect insulin sensitivity, insulin secretion, or markers of oxidative stress in subjects with type 2 diabetes mellitus.
Metabolism: clinical and experimental 2009;58(12):1753-61.
2009: Kotronen Anna; Seppälä-Lindroos Anneli; Vehkavaara Satu; Bergholm Robert; Frayn Keith N; Fielding Barbara A; Yki-Järvinen Hannele
Liver fat and lipid oxidation in humans.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(9):1439-46.
2009: Roberts R; Hodson L; Dennis A L; Neville M J; Humphreys S M; Harnden K E; Micklem K J; Frayn K N
Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.
Diabetologia 2009;52(5):882-90.
2009: Ruge Toralph; Hodson Leanne; Cheeseman Jane; Dennis A Louise; Fielding Barbara A; Humphreys Sandy M; Frayn Keith N; Karpe Fredrik
Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage.
The Journal of clinical endocrinology and metabolism 2009;94(5):1781-8.
2009: Perez-Matute Patricia; Neville Matthew J; Tan Garry D; Frayn Keith N; Karpe Fredrik
Transcriptional control of human adipose tissue blood flow.
Obesity (Silver Spring, Md.) 2009;17(4):681-8.
2009: Bertola Adeline; Deveaux Vanessa; Bonnafous Stéphanie; Rousseau Déborah; Anty Rodolphe; Wakkach Abdelilah; Dahman Moncef; Tordjman Joan; Clément Karine; McQuaid Siobhán E; Frayn Keith N; Huet Pierre-Michel; Gugenheim Jean; Lotersztajn Sophie; Le Marchand-Brustel Yannick; Tran Albert; Gual Philippe
Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity.
Diabetes 2009;58(1):125-33.
2009: Hodson Leanne; McQuaid Siobhán E; Karpe Fredrik; Frayn Keith N; Fielding Barbara A
Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate.
American journal of physiology. Endocrinology and metabolism 2009;296(1):E64-71.
2009: Funada Junichi; Betts Tim R; Hodson Leanne; Humphreys Sandy M; Timperley Jon; Frayn Keith N; Karpe Fredrik
Substrate utilization by the failing human heart by direct quantification using arterio-venous blood sampling.
PloS one 2009;4(10):e7533.
2008: Tan Garry D; Savage David B; Fielding Barbara A; Collins Jenny; Hodson Leanne; Humphreys Sandy M; O'Rahilly Stephen; Chatterjee Krishna; Frayn Keith N; Karpe Fredrik
Fatty acid metabolism in patients with PPARgamma mutations.
The Journal of clinical endocrinology and metabolism 2008;93(11):4462-70.
2008: Bickerton A S T; Roberts R; Fielding B A; Tornqvist H; Blaak E E; Wagenmakers A J M; Gilbert M; Humphreys S M; Karpe F; Frayn K N
Adipose tissue fatty acid metabolism in insulin-resistant men.
Diabetologia 2008;51(8):1466-74.
2008: Roberts Rachel; Bickerton Alex S; Fielding Barbara A; Blaak Ellen E; Wagenmakers Anton J; Chong Mary F-F; Gilbert Marjorie; Karpe Fredrik; Frayn Keith N
Reduced oxidation of dietary fat after a short term high-carbohydrate diet.
The American journal of clinical nutrition 2008;87(4):824-31.
2008: Chong Mary F-F; Hodson Leanne; Bickerton Alex S; Roberts Rachel; Neville Matt; Karpe Fredrik; Frayn Keith N; Fielding Barbara A
Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding.
The American journal of clinical nutrition 2008;87(4):817-23.
2008: Alipour Arash; van Oostrom Antonie J H H M; Izraeljan Alisa; Verseyden Caroline; Collins Jennifer M; Frayn Keith N; Plokker Thijs W M; Elte Jan Willem F; Castro Cabezas Manuel
Leukocyte activation by triglyceride-rich lipoproteins.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(4):792-7.
2008: Frayn K N; Langin D; Karpe F
Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased.
Diabetologia 2008;51(3):394-7.
2008: Evans Kevin; Burdge Graham C; Wootton Stephen A; Collins Jenny M; Clark Mo L; Tan Garry D; Karpe Fredrik; Frayn Keith N
Tissue-specific stable isotope measurements of postprandial lipid metabolism in familial combined hyperlipidaemia.
Atherosclerosis 2008;197(1):164-70.
2008: Risérus Ulf; Sprecher Dennis; Johnson Tony; Olson Eric; Hirschberg Sandra; Liu Aixue; Fang Zeke; Hegde Priti; Richards Duncan; Sarov-Blat Leli; Strum Jay C; Basu Samar; Cheeseman Jane; Fielding Barbara A; Humphreys Sandy M; Danoff Theodore; Moore Niall R; Murgatroyd Peter; O'Rahilly Stephen; Sutton Pauline; Willson Tim; Hassall David; Frayn Keith N; Karpe Fredrik
Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.
Diabetes 2008;57(2):332-9.
2007: Frayn K N; Tan G D; Karpe F
Adipose tissue: a key target for diabetes pathophysiology and treatment?
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2007;39(10):739-42.
2007: Hodson Leanne; Bickerton Alex S T; McQuaid Siobhán E; Roberts Rachel; Karpe Fredrik; Frayn Keith N; Fielding Barbara A
The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state.
Diabetes 2007;56(10):2433-41.
2007: Chong Mary F-F; Fielding Barbara A; Frayn Keith N
Mechanisms for the acute effect of fructose on postprandial lipemia.
The American journal of clinical nutrition 2007;85(6):1511-20.
2007: Karpe F; Bickerton A S; Hodson L; Fielding B A; Tan G D; Frayn K N
Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation.
Biochemical Society transactions 2007;35(Pt 3):472-6.
2007: Cadoudal T; Blouin J M; Collinet M; Fouque F; Tan G D; Loizon E; Beale E G; Frayn K N; Karpe F; Vidal H; Benelli C; Forest C
Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes.
Diabetologia 2007;50(3):666-75.
2007: Heath Richard B; Karpe Fredrik; Milne Ross W; Burdge Graham C; Wootton Stephen A; Frayn Keith N
Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E732-9.
2007: Chong Mary F F; Fielding Barbara A; Frayn Keith N
Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis.
The Proceedings of the Nutrition Society 2007;66(1):52-9.
2007: Bickerton Alex S T; Roberts Rachel; Fielding Barbara A; Hodson Leanne; Blaak Ellen E; Wagenmakers Anton J M; Gilbert Marjorie; Karpe Fredrik; Frayn Keith N
Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period.
Diabetes 2007;56(1):168-76.
2006: Tan G D; Olivecrona G; Vidal H; Frayn K N; Karpe F
Insulin sensitisation affects lipoprotein lipase transport in type 2 diabetes: role of adipose tissue and skeletal muscle in response to rosiglitazone.
Diabetologia 2006;49(10):2412-8.
2006: Frayn Keith N; Arner Peter; Yki-Järvinen Hannele
Fatty acid metabolism in adipose tissue, muscle and liver in health and disease.
Essays in biochemistry 2006;42():89-103.
2005: Frayn Keith N
Plasma non-esterified fatty acids: why are we not measuring them routinely?
Annals of clinical biochemistry 2005;42(Pt 6):413-4.
2005: Robertson M Denise; Bickerton Alex S; Dennis A Louise; Vidal Hubert; Frayn Keith N
Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism.
The American journal of clinical nutrition 2005;82(3):559-67.
2005: Tan G D; Debard C; Funahashi T; Humphreys S M; Matsuzawa Y; Frayn K N; Karpe F; Vidal H
Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy.
Diabetologia 2005;48(8):1585-9.
2005: Frayn Keith N; Fielding Barbara A; Karpe Fredrik
Adipose tissue fatty acid metabolism and cardiovascular disease.
Current opinion in lipidology 2005;16(4):409-15.
2005: Risérus Ulf; Tan Garry D; Fielding Barbara A; Neville Matt J; Currie Jenny; Savage David B; Chatterjee V Krishna; Frayn Keith N; O'Rahilly Stephen; Karpe Fredrik
Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma.
Diabetes 2005;54(5):1379-84.
2005: Karpe Fredrik; Fielding Barbara A; Coppack Simon W; Lawrence Victor J; Macdonald Ian A; Frayn Keith N
Oscillations of fatty acid and glycerol release from human subcutaneous adipose tissue in vivo.
Diabetes 2005;54(5):1297-303.
2005: Robertson M D; Bickerton A S T; Dennis A L; Vidal H; Jewell D P; Frayn K N
Enhanced metabolic cycling in subjects after colonic resection for ulcerative colitis.
The Journal of clinical endocrinology and metabolism 2005;90(5):2747-54.
2005: Frayn Keith N
Obesity and metabolic disease: is adipose tissue the culprit?
The Proceedings of the Nutrition Society 2005;64(1):7-13.
2005: Tan G D; Fielding B A; Currie J M; Humphreys S M; Désage M; Frayn K N; Laville M; Vidal H; Karpe F
The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes.
Diabetologia 2005;48(1):83-95.
2004: Fielding Barbara A; Frayn Keith N
Lipid metabolism.
Current opinion in lipidology 2004;15(4):483-5.
2004: Karpe Fredrik; Frayn Keith N
The nicotinic acid receptor--a new mechanism for an old drug.
Lancet 2004;363(9424):1892-4.
2004: Frayn Keith N; Ardilouze Jean-Luc; Fielding Barbara A; Karpe Fredrik
Coupling of metabolism and cardiovascular responses.
Clinical science (London, England : 1979) 2004;106(5):547-8.
2004: Heath R B; Jones R; Frayn K N; Robertson M D
Vagal stimulation exaggerates the inhibitory ghrelin response to oral fat in humans.
The Journal of endocrinology 2004;180(2):273-81.
2004: Ardilouze J-L; Karpe F; Currie J M; Frayn K N; Fielding B A
Subcutaneous adipose tissue blood flow varies between superior and inferior levels of the anterior abdominal wall.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(2):228-33.
2004: Ardilouze Jean-Luc; Fielding Barbara A; Currie Jenny M; Frayn Keith N; Karpe Fredrik
Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans.
Circulation 2004;109(1):47-52.
2003: Frayn K N
The glucose-fatty acid cycle: a physiological perspective.
Biochemical Society transactions 2003;31(Pt 6):1115-9.
2003: Heath Richard B; Karpe Fredrik; Milne Ross W; Burdge Graham C; Wootton Stephen A; Frayn Keith N
Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period.
Journal of lipid research 2003;44(11):2065-72.
2003: Fielding Barbara A; Frayn Keith N
Lipid metabolism.
Current opinion in lipidology 2003;14(4):389-91.
2003: Koutsari C; Karpe F; Humphreys S M; Frayn K N; Hardman A E
Plasma leptin is influenced by diet composition and exercise.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(8):901-6.
2003: Frayn K N; Karpe F; Fielding B A; Macdonald I A; Coppack S W
Integrative physiology of human adipose tissue.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(8):875-88.
2003: Tan Garry D; Debard Cyrille; Tiraby Claire; Humphreys Sandy M; Frayn Keith N; Langin Dominique; Vidal Hubert; Karpe Fredrik
A "futile cycle" induced by thiazolidinediones in human adipose tissue?
Nature medicine 2003;9(7):811-2; author reply 812.
2003: Robertson M D; Parkes M; Warren B F; Ferguson D J P; Jackson K G; Jewell D P; Frayn K N
Mobilisation of enterocyte fat stores by oral glucose in humans.
Gut 2003;52(6):834-9.
2003: Robertson M D; Currie J M; Morgan L M; Jewell D P; Frayn K N
Prior short-term consumption of resistant starch enhances postprandial insulin sensitivity in healthy subjects.
Diabetologia 2003;46(5):659-65.
2003: Ainslie Philip N; Campbell Iain T; Frayn Keith N; Humphreys Sandy M; MacLaren Donald P M; Reilly Thomas
Physiological, metabolic, and performance implications of a prolonged hill walk: influence of energy intake.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;94(3):1075-83.
2003: Beysen Carine; Belcher Abigail K; Karpe Fredrik; Fielding Barbara A; Herrera Emilio; Frayn Keith N
Novel experimental protocol to increase specific plasma nonesterified fatty acids in humans.
American journal of physiology. Endocrinology and metabolism 2003;284(1):E18-24.
2002: Robertson M D; Jackson K G; Fielding B A; Williams C M; Frayn K N
Acute effects of meal fatty acid composition on insulin sensitivity in healthy post-menopausal women.
The British journal of nutrition 2002;88(6):635-40.
2002: Beysen C; Karpe F; Fielding B A; Clark A; Levy J C; Frayn K N
Interaction between specific fatty acids, GLP-1 and insulin secretion in humans.
Diabetologia 2002;45(11):1533-41.
2002: Jackson Kim G; Robertson M Denise; Fielding Barbara A; Frayn Keith N; Williams Christine M
Olive oil increases the number of triacylglycerol-rich chylomicron particles compared with other oils: an effect retained when a second standard meal is fed.
The American journal of clinical nutrition 2002;76(5):942-9.
2002: Fielding Barbara A; Frayn Keith N
Lipid metabolism.
Current opinion in lipidology 2002;13(5):573-5.
2002: Ulahannan T J; Karpe F; Humphreys S M; Matthews D R; Frayn K N
Effects of acute administration of doxazosin on fasting and postprandial haemodynamics and lipid metabolism in healthy subjects.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(9):499-503.
2002: Frayn K N
Adipose tissue as a buffer for daily lipid flux.
Diabetologia 2002;45(9):1201-10.
2002: Evans Kevin; Burdge Graham C; Wootton Stephen A; Clark Mo L; Frayn Keith N
Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle.
Diabetes 2002;51(9):2684-90.
2002: Jackson Kim G; Robertson M Denise; Fielding Barbara A; Frayn Keith N; Williams Christine M
Measurement of apolipoprotein B-48 in the Svedberg flotation rate (S(f))>400, S(f) 60-400 and S(f) 20-60 lipoprotein fractions reveals novel findings with respect to the effects of dietary fatty acids on triacylglycerol-rich lipoproteins in postmenopausal women.
Clinical science (London, England : 1979) 2002;103(3):227-37.
2002: Karpe Fredrik; Fielding Barbara A; Ilic Vera; Macdonald Ian A; Summers Lucinda K M; Frayn Keith N
Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity.
Diabetes 2002;51(8):2467-73.
2002: Callow Joanne; Summers Lucinda K M; Bradshaw Hilary; Frayn Keith N
Changes in LDL particle composition after the consumption of meals containing different amounts and types of fat.
The American journal of clinical nutrition 2002;76(2):345-50.
2002: Ainslie P N; Campbell I T; Frayn K N; Humphreys S M; MacLaren D P M; Reilly T; Westerterp K R
Energy balance, metabolism, hydration, and performance during strenuous hill walking: the effect of age.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(2):714-23.
2002: Robertson M Denise; Jackson Kim G; Fielding Barbara A; Morgan Linda M; Williams Christine M; Frayn Keith N
Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans.
The American journal of clinical nutrition 2002;76(1):232-8.
2002: Robertson M Denise; Mason Andrew O; Frayn Keith N
Timing of vagal stimulation affects postprandial lipid metabolism in humans.
The American journal of clinical nutrition 2002;76(1):71-7.
2002: Karpe Fredrik; Fielding Barbara A; Ardilouze Jean-Luc; Ilic Vera; Macdonald Ian A; Frayn Keith N
Effects of insulin on adipose tissue blood flow in man.
The Journal of physiology 2002;540(Pt 3):1087-93.
2002: Ainslie P N; Abbas K; Campbell I T; Frayn K N; Harvie M; Keegan M A; MacLaren D P M; Macdonald I A; Paramesh K; Reilly T
Metabolic and appetite responses to prolonged walking under three isoenergetic diets.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(5):2061-70.
2002: Summers L K M; Fielding B A; Bradshaw H A; Ilic V; Beysen C; Clark M L; Moore N R; Frayn K N
Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity.
Diabetologia 2002;45(3):369-77.
2002: Karpe F; Fielding B A; Ilic V; Humphreys S M; Frayn K N
Monitoring adipose tissue blood flow in man: a comparison between the (133)xenon washout method and microdialysis.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2002;26(1):1-5.
2002: Ainslie P N; Campbell I T; Frayn K N; Humphreys S M; Maclaren D P M; Reilly T
Physiological and metabolic responses to a hill walk.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(1):179-87.
2002: Frayn Keith N
Insulin resistance, impaired postprandial lipid metabolism and abdominal obesity. A deadly triad.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2002;11 Suppl 2():31-40.
2001: Cruz M L; Evans K; Frayn K N
Postprandial lipid metabolism and insulin sensitivity in young Northern Europeans, South Asians and Latin Americans in the UK.
Atherosclerosis 2001;159(2):441-9.
2001: Summers L K; Callow J; Samra J S; Macdonald I A; Matthews D R; Frayn K N
The effect on adipose tissue blood flow of isoenergetic meals containing different amounts and types of fat.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(9):1294-9.
2001: Koutsari C; Karpe F; Humphreys S M; Frayn K N; Hardman A E
Exercise prevents the accumulation of triglyceride-rich lipoproteins and their remnants seen when changing to a high-carbohydrate diet.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1520-5.
2001: Frayn K N
Adipose tissue and the insulin resistance syndrome.
The Proceedings of the Nutrition Society 2001;60(3):375-80.
2001: Frayn K N
Effects of fat on carbohydrate absorption: more is not necessarily better.
The British journal of nutrition 2001;86(1):1-2.
2001: Gill J M; Frayn K N; Wootton S A; Miller G J; Hardman A E
Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity.
Clinical science (London, England : 1979) 2001;100(5):517-27.
2001: Evans K; Clark M L; Frayn K N
Carbohydrate and fat have different effects on plasma leptin concentrations and adipose tissue leptin production.
Clinical science (London, England : 1979) 2001;100(5):493-8.
2001: Gill J M; Mees G P; Frayn K N; Hardman A E
Moderate exercise, postprandial lipaemia and triacylglycerol clearance.
European journal of clinical investigation 2001;31(3):201-7.
2001: Jackson K G; Robertson M D; Fielding B A; Frayn K N; Williams C M
Second meal effect: modified sham feeding does not provoke the release of stored triacylglycerol from a previous high-fat meal.
The British journal of nutrition 2001;85(2):149-56.
2001: Robertson M D; Jackson K G; Williams C M; Fielding B A; Frayn K N
Prolonged effects of modified sham feeding on energy substrate mobilization.
The American journal of clinical nutrition 2001;73(1):111-7.
2000: Malkova D; Evans R D; Frayn K N; Humphreys S M; Jones P R; Hardman A E
Prior exercise and postprandial substrate extraction across the human leg.
American journal of physiology. Endocrinology and metabolism 2000;279(5):E1020-8.
2000: Fielding B A; Reid G; Grady M; Humphreys S M; Evans K; Frayn K N
Ethanol with a mixed meal increases postprandial triacylglycerol but decreases postprandial non-esterified fatty acid concentrations.
The British journal of nutrition 2000;83(6):597-604.
2000: Summers L K; Barnes S C; Fielding B A; Beysen C; Ilic V; Humphreys S M; Frayn K N
Uptake of individual fatty acids into adipose tissue in relation to their presence in the diet.
The American journal of clinical nutrition 2000;71(6):1470-7.
2000: Frayn K N
Visceral fat and insulin resistance--causative or correlative?
The British journal of nutrition 2000;83 Suppl 1():S71-7.
1999: Samra J S; Clark M L; Humphreys S M; MacDonald I A; Bannister P A; Matthews D R; Frayn K N
Suppression of the nocturnal rise in growth hormone reduces subsequent lipolysis in subcutaneous adipose tissue.
European journal of clinical investigation 1999;29(12):1045-52.
1999: Frayn K N
Macronutrient metabolism of adipose tissue at rest and during exercise: a methodological viewpoint.
The Proceedings of the Nutrition Society 1999;58(4):877-86.
1999: Summers L K; Samra J S; Frayn K N
Impaired postprandial tissue regulation of blood flow in insulin resistance: a determinant of cardiovascular risk?
Atherosclerosis 1999;147(1):11-5.
1999: Summers L K; Fielding B A; Herd S L; Ilic V; Clark M L; Quinlan P T; Frayn K N
Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat.
Journal of lipid research 1999;40(10):1890-8.
1999: Summers L K; Clark M L; Humphreys S M; Bugler J; Frayn K N
The use of microdialysis to monitor rapid changes in glucose concentration.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(7):424-8.
1999: Fielding B A; Samra J S; Ravell C L; Frayn K N
Metabolism of individual fatty acids during infusion of a triacylglycerol emulsion.
Lipids 1999;34(6):535-41.
1999: Svedman C; Samra J S; Clark M L; Levy J C; Frayn K N
Skin mini-erosion technique for monitoring metabolites in interstitial fluid: its feasibility demonstrated by OGTT results in diabetic and non-diabetic subjects.
Scandinavian journal of clinical and laboratory investigation 1999;59(2):115-23.
1998: Fielding B A; Frayn K N
Lipoprotein lipase and the disposition of dietary fatty acids.
The British journal of nutrition 1998;80(6):495-502.
1998: Frayn K N
Non-esterified fatty acid metabolism and postprandial lipaemia.
Atherosclerosis 1998;141 Suppl 1():S41-6.
1998: Karpe F; Olivecrona T; Olivecrona G; Samra J S; Summers L K; Humphreys S M; Frayn K N
Lipoprotein lipase transport in plasma: role of muscle and adipose tissues in regulation of plasma lipoprotein lipase concentrations.
Journal of lipid research 1998;39(12):2387-93.
1998: Frayn K N
Dietary factors and postprandial lipaemia.
The British journal of nutrition 1998;80(5):409-10.
1998: Abraha A; Humphreys S M; Clark M L; Matthews D R; Frayn K N
Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects.
The British journal of nutrition 1998;80(2):169-75.
1998: Samra J S; Giles S L; Summers L K; Evans R D; Arner P; Humphreys S M; Clark M L; Frayn K N
Peripheral fat metabolism during infusion of an exogenous triacylglycerol emulsion.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1998;22(8):806-12.
1998: Whitley H A; Humphreys S M; Campbell I T; Keegan M A; Jayanetti T D; Sperry D A; MacLaren D P; Reilly T; Frayn K N
Metabolic and performance responses during endurance exercise after high-fat and high-carbohydrate meals.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;85(2):418-24.
1998: Summers L K; Arner P; Ilic V; Clark M L; Humphreys S M; Frayn K N
Adipose tissue metabolism in the postprandial period: microdialysis and arteriovenous techniques compared.
The American journal of physiology 1998;274(4 Pt 1):E651-5.
1998: Saleh J; Summers L K; Cianflone K; Fielding B A; Sniderman A D; Frayn K N
Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period.
Journal of lipid research 1998;39(4):884-91.
1998: Callow J; Samra J S; Frayn K N
Effect of infusion of a triacylglycerol emulsion on low-density lipoprotein composition and oxidizability.
Atherosclerosis 1998;137(1):115-23.
1998: Summers L K; Fielding B A; Ilic V; Quinlan P T; Frayn K N
The effect of triacylglycerol-fatty acid positional distribution on postprandial metabolism in subcutaneous adipose tissue.
The British journal of nutrition 1998;79(2):141-7.
1998: Samra J S; Clark M L; Humphreys S M; MacDonald I A; Bannister P A; Frayn K N
Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue.
The Journal of clinical endocrinology and metabolism 1998;83(2):626-31.
1997: Frayn K N; Samra J S; Summers L K
Visceral fat in relation to health: is it a major culprit or simply an innocent bystander?
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(12):1191-2.
1997: Karpe F; Humphreys S M; Samra J S; Summers L K; Frayn K N
Clearance of lipoprotein remnant particles in adipose tissue and muscle in humans.
Journal of lipid research 1997;38(11):2335-43.
1997: Whitley H A; Humphreys S M; Samra J S; Campbell I T; Maclaren D P; Reilly T; Frayn K N
Metabolic responses to isoenergetic meals containing different proportions of carbohydrate and fat.
The British journal of nutrition 1997;78(1):15-26.
1997: Frayn K N; Summers L K; Fielding B A
Regulation of the plasma non-esterified fatty acid concentration in the postprandial state.
The Proceedings of the Nutrition Society 1997;56(2):713-21.
1997: Sniderman A D; Cianflone K; Summers L; Fielding B; Frayn K
The acylation-stimulating protein pathway and regulation of postprandial metabolism.
The Proceedings of the Nutrition Society 1997;56(2):703-12.
1997: Sniderman A D; Cianflone K; Frayn K
The pathogenetic role of impaired fatty acid trapping by adipocytes in generating the pleiotropic features of hyperapoB.
Diabetologia 1997;40 Suppl 2():S152-4.
1996: Samra J S; Clark M L; Humphreys S M; Macdonald I A; Matthews D R; Frayn K N
Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue.
The American journal of physiology 1996;271(6 Pt 1):E996-1002.
1996: Summers L K; Samra J S; Humphreys S M; Morris R J; Frayn K N
Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity.
Clinical science (London, England : 1979) 1996;91(6):679-83.
1996: Samra J S; Simpson E J; Clark M L; Forster C D; Humphreys S M; Macdonald I A; Frayn K N
Effects of epinephrine infusion on adipose tissue: interactions between blood flow and lipid metabolism.
The American journal of physiology 1996;271(5 Pt 1):E834-9.
1996: Samra J S; Simpson E J; Clark M L; Forster C D; Humphreys S M; Macdonald I A; Frayn K N
Effects of adrenaline infusion on the interstitial environment of subcutaneous adipose tissue as studied by microdialysis.
Clinical science (London, England : 1979) 1996;91(4):425-30.
1996: Samra J S; Summers L K; Frayn K N
Sepsis and fat metabolism.
The British journal of surgery 1996;83(9):1186-96.
1996: Halliwell K J; Fielding B A; Samra J S; Humphreys S M; Frayn K N
Release of individual fatty acids from human adipose tissue in vivo after an overnight fast.
Journal of lipid research 1996;37(9):1842-8.
1996: Frayn K N; Humphreys S M; Coppack S W
Net carbon flux across subcutaneous adipose tissue after a standard meal in normal-weight and insulin-resistant obese subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(9):795-800.
1996: Samra J S; Clark M L; Humphreys S M; Macdonald I A; Frayn K N
Regulation of lipid metabolism in adipose tissue during early starvation.
The American journal of physiology 1996;271(3 Pt 1):E541-6.
1996: Phillips D I; Caddy S; Ilic V; Fielding B A; Frayn K N; Borthwick A C; Taylor R
Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects.
Metabolism: clinical and experimental 1996;45(8):947-50.
1996: Samra J S; Ravell C L; Giles S L; Arner P; Frayn K N
Interstitial glycerol concentration in human skeletal muscle and adipose tissue is close to the concentration in blood.
Clinical science (London, England : 1979) 1996;90(6):453-6.
1996: Samra J S; Clark M L; Humphreys S M; Matthews D R; Frayn K N
Is the growth hormone concentration regulated by the morning rise in the plasma cortisol concentration?
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1996;28(5):237-40.
1996: Frayn K N; Fielding B A; Humphreys S M; Coppack S W
Nutritional influences on human adipose-tissue metabolism.
Biochemical Society transactions 1996;24(2):422-6.
1996: Coppack S W; Fisher R M; Humphreys S M; Clark M L; Pointon J J; Frayn K N
Carbohydrate metabolism in insulin resistance: glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal.
Clinical science (London, England : 1979) 1996;90(5):409-15.
1996: Fielding B A; Callow J; Owen R M; Samra J S; Matthews D R; Frayn K N
Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals.
The American journal of clinical nutrition 1996;63(1):36-41.
1995: Frayn K N
Physiological regulation of macronutrient balance.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1995;19 Suppl 5():S4-10.
1995: Fielding B A; Humphreys S M; Shadid S; Frayn K N
Plasma mono-, di- and triacylglycerol measurements in a study of fat uptake by human adipose tissue in vivo.
Biochemical Society transactions 1995;23(3):487S.
1995: Carr R E; Sherrington E J; Calder P C; Frayn K N
Lipolysis in rat adipose tissue in vitro is dependent on the quantity and not the quality of dietary fat.
Biochemical Society transactions 1995;23(3):486S.
1995: Samra J S; Frayn K N; Summers L K
Inadequate levels of metronidazole in subcutaneous fat after standard prophylaxis.
The British journal of surgery 1995;82(8):1139.
1995: Frayn K N; Kingman S M
Dietary sugars and lipid metabolism in humans.
The American journal of clinical nutrition 1995;62(1 Suppl):250S-261S; discussion 261S-263S.
1995: Samra J S; Frayn K N; Giddings J A; Clark M L; Macdonald I A
Modification and validation of a commercially available portable detector for measurement of adipose tissue blood flow.
Clinical physiology (Oxford, England) 1995;15(3):241-8.
1995: Potts J L; Coppack S W; Fisher R M; Humphreys S M; Gibbons G F; Frayn K N
Impaired postprandial clearance of triacylglycerol-rich lipoproteins in adipose tissue in obese subjects.
The American journal of physiology 1995;268(4 Pt 1):E588-94.
1995: Fisher R M; Coppack S W; Humphreys S M; Gibbons G F; Frayn K N
Human triacylglycerol-rich lipoprotein subfractions as substrates for lipoprotein lipase.
Clinica chimica acta; international journal of clinical chemistry 1995;236(1):7-17.
1995: Carr R E; Humphreys S M; Frayn K N
Catecholamine interference with enzymatic determination of nonesterified fatty acids in two commercially available test kits.
Clinical chemistry 1995;41(3):455-7.
1995: Frayn K N; Humphreys S M; Coppack S W
Fuel selection in white adipose tissue.
The Proceedings of the Nutrition Society 1995;54(1):177-89.
1995: Frayn K N; Coppack S W; Fielding B A; Humphreys S M
Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization.
Advances in enzyme regulation 1995;35():163-78.
1994: Potts J L; Fisher R M; Humphreys S M; Gibbons G F; Frayn K N
Separation of lipoprotein fractions by ultracentrifugation: investigation of analytical recovery with sequential flotation and density gradient procedures.
Clinica chimica acta; international journal of clinical chemistry 1994;230(2):215-20.
1994: Potts J L; Humphreys S M; Coppack S W; Fisher R M; Gibbons G F; Frayn K N
Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal.
The British journal of nutrition 1994;72(1):101-9.
1994: Carr R E; Bourgeois C S; Frayn K N; Gibbons G F
A convenient method for assaying insulin responsiveness of rat adipose tissue in primary culture.
Biochemical Society transactions 1994;22(2):100S.
1994: Frayn K N; Shadid S; Hamlani R; Humphreys S M; Clark M L; Fielding B A; Boland O; Coppack S W
Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition.
The American journal of physiology 1994;266(3 Pt 1):E308-17.
1994: Griffiths A J; Humphreys S M; Clark M L; Frayn K N
Forearm substrate utilization during exercise after a meal containing both fat and carbohydrate.
Clinical science (London, England : 1979) 1994;86(2):169-75.
1994: Griffiths A J; Humphreys S M; Clark M L; Fielding B A; Frayn K N
Immediate metabolic availability of dietary fat in combination with carbohydrate.
The American journal of clinical nutrition 1994;59(1):53-9.
1993: Frayn K N; Coppack S W; Humphreys S M
Subcutaneous adipose tissue metabolism studied by local catheterization.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1993;17 Suppl 3():S18-21; discussion S22.
1993: Fisher R M; Potts J L; Frayn K N
Immunoturbidimetric measurement of low concentrations of apolipoprotein B in lipaemic samples.
Annals of clinical biochemistry 1993;30 ( Pt 6)():584-6.
1993: Fielding B A; Humphreys S M; Frayn K N
Mono- and di-acylglycerol concentrations in human plasma in relation to lipoprotein lipase activity.
Biochemical Society transactions 1993;21 ( Pt 3)(3):235S.
1993: Frayn K N; Langin D; Holm C; Belfrage P
Hormone-sensitive lipase: quantitation of enzyme activity and mRNA level in small biopsies of human adipose tissue.
Clinica chimica acta; international journal of clinical chemistry 1993;216(1-2):183-9.
1993: Fielding B A; Humphreys S M; Allman R F; Frayn K N
Mono-, di- and triacylglycerol concentrations in human plasma: effects of heparin injection and of a high-fat meal.
Clinica chimica acta; international journal of clinical chemistry 1993;216(1-2):167-73.
1993: Fisher R M; Coppack S W; Gibbons G F; Frayn K N
Post-prandial VLDL subfraction metabolism in normal and obese subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1993;17(5):263-9.
1993: Frayn K N; Coppack S W; Humphreys S M; Clark M L; Evans R D
Periprandial regulation of lipid metabolism in insulin-treated diabetes mellitus.
Metabolism: clinical and experimental 1993;42(4):504-10.
1992: Frayn K N; Coppack S W; Potts J L
Effect of diet on human adipose tissue metabolism.
The Proceedings of the Nutrition Society 1992;51(3):409-18.
1992: Boulton K L; Hudson D U; Coppack S W; Frayn K N
Steroid hormone interconversions in human adipose tissue in vivo.
Metabolism: clinical and experimental 1992;41(5):556-9.
1992: Coppack S W; Evans R D; Fisher R M; Frayn K N; Gibbons G F; Humphreys S M; Kirk M L; Potts J L; Hockaday T D
Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal.
Metabolism: clinical and experimental 1992;41(3):264-72.
1991: Frayn K N; Coppack S W; Humphreys S M
Glycerol and lactate uptake in human forearm.
Metabolism: clinical and experimental 1991;40(12):1317-9.
1991: Potts J L; Fisher R M; Humphreys S M; Coppack S W; Gibbons G F; Frayn K N
Peripheral triacylglycerol extraction in the fasting and post-prandial states.
Clinical science (London, England : 1979) 1991;81(5):621-6.
1991: Hodgetts V; Coppack S W; Frayn K N; Hockaday T D
Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;71(2):445-51.
1991: Potts J L; Fisher R M; Humphreys S M; Coppack S W; Gibbons G F; Frayn K N
Chylomicrons are the preferred substrate for lipoprotein lipase in vivo.
Biochemical Society transactions 1991;19(3):314S.
1991: Frayn K N; Khan K; Coppack S W; Elia M
Amino acid metabolism in human subcutaneous adipose tissue in vivo.
Clinical science (London, England : 1979) 1991;80(5):471-4.
1990: Potts J L; Fisher R M; Coppack S W; Gibbons G F; Frayn K N
Lipoprotein interconversions during passage through subcutaneous adipose tissue in humans in vivo.
Biochemical Society transactions 1990;18(6):1196-7.
1990: Humphreys S M; Fisher R M; Frayn K N
Micro-method for measurement of sub-nanomole amounts of triacylglycerol.
Annals of clinical biochemistry 1990;27 ( Pt 6)():597-8.
1990: Coppack S W; Fisher R M; Gibbons G F; Humphreys S M; McDonough M J; Potts J L; Frayn K N
Postprandial substrate deposition in human forearm and adipose tissues in vivo.
Clinical science (London, England : 1979) 1990;79(4):339-48.
1990: Frayn K N; Coppack S W; Walsh P E; Butterworth H C; Humphreys S M; Pedrosa H C
Metabolic responses of forearm and adipose tissues to acute ethanol ingestion.
Metabolism: clinical and experimental 1990;39(9):958-66.
1990: Clark M L; Humphreys S M; Frayn K N
Stability of plasma glucose during storage.
Annals of clinical biochemistry 1990;27 ( Pt 4)():373-7.
1990: Coppack S W; Frayn K N; Humphreys S M; Whyte P L; Hockaday T D
Arteriovenous differences across human adipose and forearm tissues after overnight fast.
Metabolism: clinical and experimental 1990;39(4):384-90.
1990: Dhar H; Fielding B A; Clark M L; Frayn K N
Background turbidity changes during the estimation of urinary albumin.
Annals of clinical biochemistry 1990;27 ( Pt 2)():161-2.
1989: Coppack S W; Frayn K N; Humphreys S M; Dhar H; Hockaday T D
Effects of insulin on human adipose tissue metabolism in vivo.
Clinical science (London, England : 1979) 1989;77(6):663-70.
1989: Frayn K N; Coppack S W; Humphreys S M
Possible importance of glycogen in human adipose tissue.
Biochemical Society transactions 1989;17(6):1091.
1989: Frayn K N; Coppack S W; Humphreys S M; Whyte P L
Metabolic characteristics of human adipose tissue in vivo.
Clinical science (London, England : 1979) 1989;76(5):509-16.
1988: Humphreys S M; Frayn K N
Micro-method for preparing perchloric extracts of blood.
Clinical chemistry 1988;34(8):1657.
1987: Akanji A O; Bruce M; Frayn K; Hockaday T D; Kaddaha G M
Oral glucose tolerance and ambient temperature in non-diabetic subjects.
Diabetologia 1987;30(6):431-3.

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